Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.102722
A. Jouyban
Aim: To represent mathematically the reported physico-chemical properties (PCPs) of binary mixtures of 3 bromoanisol + methanol at various temperatures by using a single model with seven curve-fit parameters. Results: Besides the correlation models, the applicability of training the proposed model using a minimum number of experimental data and prediction of the rest of data points with acceptable prediction error is also shown.
{"title":"Simulation of density, viscosity and ultrasonic velocity data of 3-bromoanisole + methanol mixtures at different temperatures","authors":"A. Jouyban","doi":"10.15446/rcciquifa.v51n1.102722","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.102722","url":null,"abstract":"Aim: To represent mathematically the reported physico-chemical properties (PCPs) of binary mixtures of 3 bromoanisol + methanol at various temperatures by using a single model with seven curve-fit parameters. Results: Besides the correlation models, the applicability of training the proposed model using a minimum number of experimental data and prediction of the rest of data points with acceptable prediction error is also shown.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"49 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85979655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.102727
Volodymyr V. Tkach, Martha V. Kushnir, Y. G. Ivanushko, S. C. De Oliveira, Lucinda Vaz dos Reis, Petro I. Yagodynets´, Zholt O. Kormosh
Introducción: en este trabajo se evalúa desde el punto de vista mecanístico teórico el comportamiento electroanalítico del compuesto oxihidróxido de vanadio colorante escuárico en la detección de la carfedona. El proceso electroanalítico incluye la formación de dos formas de vanadio tetravalente, incluyendo el dióxido de vanadio e ion vanadilo. Método: un mecanismo, capaz de describir el comportamiento del sensor, ha sido sugerido y un modelo matemático fue desarrollado y analizado mediante la teoría de estabilidad lineal y análisis de bifurcaciones. Resultados: el análisis del modelo ha probado que la dependencia lineal entre la concentración del fármaco y el parámetro electroquímico se mantiene firme en la ancha región topológica de parámetros. Las inestabilidades oscilatoria y monotónica suelen realizarse cuando son causadas por influencias fuertes de las etapas química y electroquímica en la capacitancia de la doble capa eléctrica. Conclusiones: el compuesto de nanopartículas de oxihidróxido de vanadio (estabilizadas con el colorante escuárico) puede servir como un modificador eficiente de electrodo para la detección de lacarfedona. El oxihidróxido de vanadio desempeña funciones de sustancia activa y el colorante, de la mediadora.
{"title":"Descripción teórica del desempeño electroanalítico del material compuesto de oxihidróxido de vanadio con el colorante escuárico en la detección de la carfedona","authors":"Volodymyr V. Tkach, Martha V. Kushnir, Y. G. Ivanushko, S. C. De Oliveira, Lucinda Vaz dos Reis, Petro I. Yagodynets´, Zholt O. Kormosh","doi":"10.15446/rcciquifa.v51n1.102727","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.102727","url":null,"abstract":"Introducción: en este trabajo se evalúa desde el punto de vista mecanístico teórico el comportamiento electroanalítico del compuesto oxihidróxido de vanadio colorante escuárico en la detección de la carfedona. El proceso electroanalítico incluye la formación de dos formas de vanadio tetravalente, incluyendo el dióxido de vanadio e ion vanadilo. Método: un mecanismo, capaz de describir el comportamiento del sensor, ha sido sugerido y un modelo matemático fue desarrollado y analizado mediante la teoría de estabilidad lineal y análisis de bifurcaciones. Resultados: el análisis del modelo ha probado que la dependencia lineal entre la concentración del fármaco y el parámetro electroquímico se mantiene firme en la ancha región topológica de parámetros. Las inestabilidades oscilatoria y monotónica suelen realizarse cuando son causadas por influencias fuertes de las etapas química y electroquímica en la capacitancia de la doble capa eléctrica. Conclusiones: el compuesto de nanopartículas de oxihidróxido de vanadio (estabilizadas con el colorante escuárico) puede servir como un modificador eficiente de electrodo para la detección de lacarfedona. El oxihidróxido de vanadio desempeña funciones de sustancia activa y el colorante, de la mediadora.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"20 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85905129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.102729
Karolaine Goméz Palencia, Laura Goméz de la Cruz, Alberto Herrera Marquéz, Reinaldo G. Sotomayor
Introdución: el estradiol es una hormona esteroide sexual femenina usada ampliamente como terapia hormonal que presenta una baja biodisponibilidad, debido asu baja solubilidad acuosa y a su alta hidrofobicidad, perteneciendo a la clase II del sistema de clasificación de biofarmacéutica. Objetivos: diseñar y caracterizar un sistema de entrega de fármacos autoemulsificable (SEDDS) para el fármaco estradiol por pruebas fisicoquímicas con el fin de obtener la relación óptima que permitiera mejorar su solubilidad acuosa, velocidad de disolución y potencialmente su biodisponibilidad. Método: estudios de solubilidad en diferentes solventes, diagramas de fases pseudoternarios constituidos por aceites, tensioactivos, cotensioactivos y agua permitieron reconocer las diferentes regiones de formación de SEDDS e identificar los porcentajes de excipientes que conducen a la formación de soluciones isotrópicas; las formulaciones resultantes fueron caracterizadas en tiempo de autoemulsificación, robustez a la dilución, punto de nube y perfil de disolución en capsula dura. Resultados: las formulaciones que contenían Capmul MCM®, Kolliphor® RH40 y Transcutol®, tuvieron un tiempo de autoemulsificación de aproximadamente 1 min; fueron estables en tres distintos pH (1,2; 4,5 y 7,2), en diferentes volúmenes de dilución, exhibiendo una apariencia transparente, ligeramente azulada, sin precipitados, o separación de fases, puntos de nube mayores en comparación de las formulaciones que contenían Gelucire® 44/14. Conclusiones: las estrategias de caracterizaciónempleadas en el desarrollo de esta investigación demostraron ser eficientes para la selección adecuada de excipientes y su proporción óptima para el diseño eficaz de un sistema de entrega de fármaco autoemulsificable (SEDDS).
{"title":"Diseño y caracterización de un sistema de entrega de fármacos autoemulsificable (SEDDS) de estradiol por diagramas de fases pseudoternarios y pruebas fisicoquímicas","authors":"Karolaine Goméz Palencia, Laura Goméz de la Cruz, Alberto Herrera Marquéz, Reinaldo G. Sotomayor","doi":"10.15446/rcciquifa.v51n1.102729","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.102729","url":null,"abstract":"Introdución: el estradiol es una hormona esteroide sexual femenina usada ampliamente como terapia hormonal que presenta una baja biodisponibilidad, debido asu baja solubilidad acuosa y a su alta hidrofobicidad, perteneciendo a la clase II del sistema de clasificación de biofarmacéutica. Objetivos: diseñar y caracterizar un sistema de entrega de fármacos autoemulsificable (SEDDS) para el fármaco estradiol por pruebas fisicoquímicas con el fin de obtener la relación óptima que permitiera mejorar su solubilidad acuosa, velocidad de disolución y potencialmente su biodisponibilidad. Método: estudios de solubilidad en diferentes solventes, diagramas de fases pseudoternarios constituidos por aceites, tensioactivos, cotensioactivos y agua permitieron reconocer las diferentes regiones de formación de SEDDS e identificar los porcentajes de excipientes que conducen a la formación de soluciones isotrópicas; las formulaciones resultantes fueron caracterizadas en tiempo de autoemulsificación, robustez a la dilución, punto de nube y perfil de disolución en capsula dura. Resultados: las formulaciones que contenían Capmul MCM®, Kolliphor® RH40 y Transcutol®, tuvieron un tiempo de autoemulsificación de aproximadamente 1 min; fueron estables en tres distintos pH (1,2; 4,5 y 7,2), en diferentes volúmenes de dilución, exhibiendo una apariencia transparente, ligeramente azulada, sin precipitados, o separación de fases, puntos de nube mayores en comparación de las formulaciones que contenían Gelucire® 44/14. Conclusiones: las estrategias de caracterizaciónempleadas en el desarrollo de esta investigación demostraron ser eficientes para la selección adecuada de excipientes y su proporción óptima para el diseño eficaz de un sistema de entrega de fármaco autoemulsificable (SEDDS).","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72795653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.95974
Patrícia Espinosa Dos Santos, Marcos Serrou do Amaral, Nájla Mohamad Kassab
Aim: To develop and to validate a simple, sensitive and fast method for the simultaneous determination of sulfamethoxazole (SMT), trimethoprim (TMP) and bromhexine (BMX) in veterinary formulation by high performance liquid chromatography according to the guidelines of the Validation and Control Guide for analytical quality of medicines in food products and veterinary medicines, RDC 166/2017 and international guides International Conference on Harmonization and International Association of Official Analytical Chemists. Materials and methods:The separation was performed on a ThermoScientific® C18 AcclaimTM120 analytical column (4.6 × 250 mm, 5 µm), with a flow rate of 0.7 mL min-1 and detection at 245 nm, 265 nm and 271 nm, for BMX, SMT and TMP, respectively. All measurements were performed in methanol: water (84:16 v/v; pH 3.0). The analytical curves were linear (r > 0.9997) in the concentration range of 15.0 to 30.0 μg·mL-1 for SMT, 3.0 to 9.0 μg·mL-1 for TMP and 0.5 to 2.0 μg·mL-1 for BMX. Results: The method proved to be accurate, with coefficients of variation below the maximum limit of 2.0%, robust, without significant influence of the variations used in the analysis, exact (recovery >99%) and selective, in the assessment of interference from adjuvants. Conclusion:Therefore, the developed method proved to be suitable for routine quality control analyzes for the simultaneous determination of SMT, TMP and BMX in pharmaceutical formulations.
{"title":"Simultaneous determination of sulfamethoxazole, trimethoprim and bromhexine in veterinary formulation using high performance liquid chromatography (HPLC)","authors":"Patrícia Espinosa Dos Santos, Marcos Serrou do Amaral, Nájla Mohamad Kassab","doi":"10.15446/rcciquifa.v51n1.95974","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.95974","url":null,"abstract":"Aim: To develop and to validate a simple, sensitive and fast method for the simultaneous determination of sulfamethoxazole (SMT), trimethoprim (TMP) and bromhexine (BMX) in veterinary formulation by high performance liquid chromatography according to the guidelines of the Validation and Control Guide for analytical quality of medicines in food products and veterinary medicines, RDC 166/2017 and international guides International Conference on Harmonization and International Association of Official Analytical Chemists. Materials and methods:The separation was performed on a ThermoScientific® C18 AcclaimTM120 analytical column (4.6 × 250 mm, 5 µm), with a flow rate of 0.7 mL min-1 and detection at 245 nm, 265 nm and 271 nm, for BMX, SMT and TMP, respectively. All measurements were performed in methanol: water (84:16 v/v; pH 3.0). The analytical curves were linear (r > 0.9997) in the concentration range of 15.0 to 30.0 μg·mL-1 for SMT, 3.0 to 9.0 μg·mL-1 for TMP and 0.5 to 2.0 μg·mL-1 for BMX. Results: The method proved to be accurate, with coefficients of variation below the maximum limit of 2.0%, robust, without significant influence of the variations used in the analysis, exact (recovery >99%) and selective, in the assessment of interference from adjuvants. Conclusion:Therefore, the developed method proved to be suitable for routine quality control analyzes for the simultaneous determination of SMT, TMP and BMX in pharmaceutical formulations.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83130982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.102726
J. López G., Carlos Mauricio Calderón V., Y. Cortázar C
Introduction: Studying the prescription of last generation antibiotics helps to identify the causes and consequences of the inadequate use of antibiotics. These include the appearance of antibacterial resistance, a situation declared by the WHO as a global public health problem. Aim: To describe the prescription of linezolid in a high complexity hospital in Bogotá, Colombia,considering the follow-up of the recommendations for the use of the drug included in clinical practice guidelines (CPG) and its indications. Methods: A descriptive observational study of longitudinal section was performed with retrospective collection of the information of all patients who were prescribed linezolid, at a minimum dose of 600 mg every 12 h during their hospitalization in the period from January 1st, 2017, to December 31st, 2018. The characteristics of linezolid prescription were described. Results: 133 prescriptions were reviewed. The most frequently diagnosed were sepsis of different origin (pulmonary abdominal, urinary) with 22.6 % (30/133), followed by skin and soft tissue infection 16.5 % (22/133), the pneumonia with 12.8 % (17/133) and urinary tract infections with 9.8 % (13/133). Two days treatment was the most frequent (range 1-30 days). In 33 % (44/133) of the patients, linezolid was used empirically (without using a previous antibiotic), while in 40.6 % (54/133) it was used as a second option (a previous antibiotic scheme). It was used as a third option in 20.3 % (27/133). Finally, in 6 % (8/133) of the patients, linezolid was prescribed after three previous antibiotics. It was necessary to use another antibiotic in near fifty percent of patients because linezolid did not work. Conclusions: The present study shows that there is little adherence to the institutional CPGs in relation to the treatment time, the microorganism identification, and the use as first option. The absence of a full-time infectious disease specialist, the high workload and the continuous rotation of prescribing staff may be the causeof these results. Some cases of inappropriate use may be related to the clinicalcondition of the patient which requires empirical treatments.
{"title":"Use of linezolid in a high complexity hospital of Bogotá city","authors":"J. López G., Carlos Mauricio Calderón V., Y. Cortázar C","doi":"10.15446/rcciquifa.v51n1.102726","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.102726","url":null,"abstract":"Introduction: Studying the prescription of last generation antibiotics helps to identify the causes and consequences of the inadequate use of antibiotics. These include the appearance of antibacterial resistance, a situation declared by the WHO as a global public health problem. Aim: To describe the prescription of linezolid in a high complexity hospital in Bogotá, Colombia,considering the follow-up of the recommendations for the use of the drug included in clinical practice guidelines (CPG) and its indications. Methods: A descriptive observational study of longitudinal section was performed with retrospective collection of the information of all patients who were prescribed linezolid, at a minimum dose of 600 mg every 12 h during their hospitalization in the period from January 1st, 2017, to December 31st, 2018. The characteristics of linezolid prescription were described. Results: 133 prescriptions were reviewed. The most frequently diagnosed were sepsis of different origin (pulmonary abdominal, urinary) with 22.6 % (30/133), followed by skin and soft tissue infection 16.5 % (22/133), the pneumonia with 12.8 % (17/133) and urinary tract infections with 9.8 % (13/133). Two days treatment was the most frequent (range 1-30 days). In 33 % (44/133) of the patients, linezolid was used empirically (without using a previous antibiotic), while in 40.6 % (54/133) it was used as a second option (a previous antibiotic scheme). It was used as a third option in 20.3 % (27/133). Finally, in 6 % (8/133) of the patients, linezolid was prescribed after three previous antibiotics. It was necessary to use another antibiotic in near fifty percent of patients because linezolid did not work. Conclusions: The present study shows that there is little adherence to the institutional CPGs in relation to the treatment time, the microorganism identification, and the use as first option. The absence of a full-time infectious disease specialist, the high workload and the continuous rotation of prescribing staff may be the causeof these results. Some cases of inappropriate use may be related to the clinicalcondition of the patient which requires empirical treatments.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84396343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.102607
José Odimar De Caldas Brandão Filho, José Pedro Martins Barbosa Filho, Rafaela Damasceno Sá, Karina Perrelli Randau
Introduction: Chronic non-communicable diseases (CNCDs) are a group of diseases characterized by having the highest mortality and morbidity rates in the world. Despite the increase in new drug technologies, the use of medicinal plants as an aid in therapy for these diseases is a widespread reality. However, most plant species contain inorganic crystals of calcium oxalate, a product of plant metabolism, which has several functions in plant tissues. For the human species, its ingestion is associated with the arising of kidney problems such as urinary lithiasis, especially in people who have a predisposition to these conditions. Aim: To determine the amount of oxalic acid in plant species, which are used in the treatment of CNCDs. Methodology: After collection and characterization the plant species, aqueous and acidic extracts were obtained from 0.5 g of the plant drug of each species and, subsequently, were titrated with a standardized 0.02 mol.L-1 potassium permanganate solution and the concentrations of oxalic acid were expressed in g/100 g of dry vegetable drug. Result: The data obtained from the concentration of oxalic acid ranged from 4.58 ± 0.09 g/100 g to 17.21 ± 0.07 g/100 g and demonstrated that the concentrations from acid extraction are higher compared to the aqueous extraction, for all vegetables species analyzed. Methodological optimization was performed for the species that showed the highest results, Psidium guajava and Artocarpus heterophyllus. Conclusion: The data obtained can serve as input for medical decisions and for professionals who prescribe medicinal plants.
简介:慢性非传染性疾病是世界上死亡率和发病率最高的一组疾病。尽管新的药物技术有所增加，但使用药用植物作为辅助治疗这些疾病是一个普遍的现实。然而，大多数植物物种都含有草酸钙的无机晶体，草酸钙是植物代谢的产物，在植物组织中具有多种功能。对于人类来说，它的摄入与尿石症等肾脏问题的出现有关，尤其是那些有这些疾病倾向的人。目的:测定用于治疗慢性慢性疾病的植物中草酸的含量。方法:在植物种类的采集和鉴定后，分别从每种植物的0.5 g植物药中提取水提液和酸提液，然后用标准的0.02 mol.L-1高锰酸钾溶液滴定，草酸浓度以g/100 g干植物药表示。结果:草酸的浓度范围为4.58±0.09 g/100 g ~ 17.21±0.07 g/100 g，酸提法的草酸浓度均高于水提法。方法优选结果表明，瓜爪哇石楠和异叶石楠含量最高。结论:获得的数据可作为医疗决策的输入，也可为专业人员开药用植物处方提供参考。
{"title":"Extraction and quantification of oxalic acid in leaves of plant species used in the treatment of chronic non-communicable diseases","authors":"José Odimar De Caldas Brandão Filho, José Pedro Martins Barbosa Filho, Rafaela Damasceno Sá, Karina Perrelli Randau","doi":"10.15446/rcciquifa.v51n1.102607","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.102607","url":null,"abstract":"Introduction: Chronic non-communicable diseases (CNCDs) are a group of diseases characterized by having the highest mortality and morbidity rates in the world. Despite the increase in new drug technologies, the use of medicinal plants as an aid in therapy for these diseases is a widespread reality. However, most plant species contain inorganic crystals of calcium oxalate, a product of plant metabolism, which has several functions in plant tissues. For the human species, its ingestion is associated with the arising of kidney problems such as urinary lithiasis, especially in people who have a predisposition to these conditions. Aim: To determine the amount of oxalic acid in plant species, which are used in the treatment of CNCDs. Methodology: After collection and characterization the plant species, aqueous and acidic extracts were obtained from 0.5 g of the plant drug of each species and, subsequently, were titrated with a standardized 0.02 mol.L-1 potassium permanganate solution and the concentrations of oxalic acid were expressed in g/100 g of dry vegetable drug. Result: The data obtained from the concentration of oxalic acid ranged from 4.58 ± 0.09 g/100 g to 17.21 ± 0.07 g/100 g and demonstrated that the concentrations from acid extraction are higher compared to the aqueous extraction, for all vegetables species analyzed. Methodological optimization was performed for the species that showed the highest results, Psidium guajava and Artocarpus heterophyllus. Conclusion: The data obtained can serve as input for medical decisions and for professionals who prescribe medicinal plants.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85046205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-07-07DOI: 10.15446/rcciquifa.v51n1.102693
Hebert Jair Barrales-Cureño, B. Herrera-Cabrera, Jorge Montiel Montoya, L. G. López-Valdez, R. Salgado-Garciglia, V. Ocaño-Higuera, L. M. Sánchez-Herrera, G. G. Lucho-Constantino, Fabiola Zaragoza-Martínez
Introduction: Allelopathy is a harmful effect indirectly or directly produced by one plant to another through the production of chemical substances that enter the environment. Allelopathy has a pertinent significance for systems of ecological, sustainable, and integrated management. These natural reactions have multiple effects, ranging from processes of inhibition and stimulation of growth in neighbor plants to inhibition of seed germination. Metabolomics is a discipline integral that studies all the metabolites in a particular tissue, organ, or organism in a specific developmental stage or under particular environmental conditions, and it allows for the assessment of the contribution of genetic and environmental factors to the modification of metabolism. With the growing number of “omics”, new approaches can be used to understand metabolic changes that occur in plants, especially in proteomics and metabolomics, and thus those analyses could be profiled in coming years with the objective of knowing the allelopathome of a larger number of plant species and their interactions. Aim: To provide a recent update on the science of allelopathy in the context of physiology, practical application of metabolomics in allelopathic studies, allelochemicals analyzed by metabolomics in alfalfa, rice, canola, sorghum, rye, wheat and other crops and finally mentionated the biological activity of allelopathic secondary metabolites. Methods: A recent comprehensive literature search of allelopathy and metabolomics in journal databases was carried out. Results: The concept of allelopathy, allelopathic mechanisms, metabolomic studies in allelopathy, allelochemicals analysed by metabolomics in alfalfa, rice, canola, rye sorghum, wheat and other agro-industrially important crops, and the biological activity of allelopathic secondary metabolites are detailed. Conclusions: These studies suggest that a combination of secondary metabolites can be used to attack weeds. In situ and In vitro culture of secondary metabolites (allelochemical types) is recommended to be used as organics compounds in weed organic control in the future.
{"title":"Metabolomics studies of allelopathy: a review","authors":"Hebert Jair Barrales-Cureño, B. Herrera-Cabrera, Jorge Montiel Montoya, L. G. López-Valdez, R. Salgado-Garciglia, V. Ocaño-Higuera, L. M. Sánchez-Herrera, G. G. Lucho-Constantino, Fabiola Zaragoza-Martínez","doi":"10.15446/rcciquifa.v51n1.102693","DOIUrl":"https://doi.org/10.15446/rcciquifa.v51n1.102693","url":null,"abstract":"Introduction: Allelopathy is a harmful effect indirectly or directly produced by one plant to another through the production of chemical substances that enter the environment. Allelopathy has a pertinent significance for systems of ecological, sustainable, and integrated management. These natural reactions have multiple effects, ranging from processes of inhibition and stimulation of growth in neighbor plants to inhibition of seed germination. Metabolomics is a discipline integral that studies all the metabolites in a particular tissue, organ, or organism in a specific developmental stage or under particular environmental conditions, and it allows for the assessment of the contribution of genetic and environmental factors to the modification of metabolism. With the growing number of “omics”, new approaches can be used to understand metabolic changes that occur in plants, especially in proteomics and metabolomics, and thus those analyses could be profiled in coming years with the objective of knowing the allelopathome of a larger number of plant species and their interactions. Aim: To provide a recent update on the science of allelopathy in the context of physiology, practical application of metabolomics in allelopathic studies, allelochemicals analyzed by metabolomics in alfalfa, rice, canola, sorghum, rye, wheat and other crops and finally mentionated the biological activity of allelopathic secondary metabolites. Methods: A recent comprehensive literature search of allelopathy and metabolomics in journal databases was carried out. Results: The concept of allelopathy, allelopathic mechanisms, metabolomic studies in allelopathy, allelochemicals analysed by metabolomics in alfalfa, rice, canola, rye sorghum, wheat and other agro-industrially important crops, and the biological activity of allelopathic secondary metabolites are detailed. Conclusions: These studies suggest that a combination of secondary metabolites can be used to attack weeds. In situ and In vitro culture of secondary metabolites (allelochemical types) is recommended to be used as organics compounds in weed organic control in the future.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83014709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-04DOI: 10.15446/rcciquifa.v50n3.92935
Carmenza Janneth Benavides Melo, María C. García-Cabrera, Olga T. Guerron-Morales, Juan M. Astaiza-Martínez
Introducción: la marihuana (Cannabis sativa L.)es una planta originaria de Asia cada vez más reconocida por su valor terapéutico en la medicina humana y veteri-naria.Contiene una gran cantidad de componentes entre los que destacan los fito-cannabinoides, de los cuales los más representativos son el delta-9-tetrahidrocanna-binol (THC) y Cannabidiol (CBD) que se acoplan respectivamente a los receptores CB1 y CB2 en el sistema endocannabinoide que es un sistema neurotransmisor entre células que regula varios procesos en los vertebrados como memoria, dolor, inflamación, apetito y procesos inmunológicos entre otros. Objetivo: realizar una síntesis narrativa del sistema endocannabinoide y cannabidiol en el manejo del dolor en perros, a partir de la búsqueda de publicaciones en bases de datos electrónica PubMed, NCBI, SciELO, Science Direct, Dialnet, Google y Google Académico. Resultados: el CBD es el principal cannabinoide utilizado en la terapia del manejo del dolor en perros por sus propiedades analgésicas y carencia de efectos psicoactivos. Conclusión: se evidencia la necesidad de realizar más investigaciones con ensayos clínicos controlados sobre el uso terapéutico del cannabidiol, que tengan validez interna y externa, con poblaciones más significativas en la especie de interés.
{"title":"Sistema endocannabinoide y cannabidiol en el manejo del dolor en perros: revisión narrativa","authors":"Carmenza Janneth Benavides Melo, María C. García-Cabrera, Olga T. Guerron-Morales, Juan M. Astaiza-Martínez","doi":"10.15446/rcciquifa.v50n3.92935","DOIUrl":"https://doi.org/10.15446/rcciquifa.v50n3.92935","url":null,"abstract":"Introducción: la marihuana (Cannabis sativa L.)es una planta originaria de Asia cada vez más reconocida por su valor terapéutico en la medicina humana y veteri-naria.Contiene una gran cantidad de componentes entre los que destacan los fito-cannabinoides, de los cuales los más representativos son el delta-9-tetrahidrocanna-binol (THC) y Cannabidiol (CBD) que se acoplan respectivamente a los receptores CB1 y CB2 en el sistema endocannabinoide que es un sistema neurotransmisor entre células que regula varios procesos en los vertebrados como memoria, dolor, inflamación, apetito y procesos inmunológicos entre otros. Objetivo: realizar una síntesis narrativa del sistema endocannabinoide y cannabidiol en el manejo del dolor en perros, a partir de la búsqueda de publicaciones en bases de datos electrónica PubMed, NCBI, SciELO, Science Direct, Dialnet, Google y Google Académico. Resultados: el CBD es el principal cannabinoide utilizado en la terapia del manejo del dolor en perros por sus propiedades analgésicas y carencia de efectos psicoactivos.\u0000Conclusión: se evidencia la necesidad de realizar más investigaciones con ensayos clínicos controlados sobre el uso terapéutico del cannabidiol, que tengan validez interna y externa, con poblaciones más significativas en la especie de interés.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85317209","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-04DOI: 10.15446/rcciquifa.v50n3.90724
R. J. Pereira, M. Cardoso, M. A. Andrade, R. J. Pereira
Introduction: there is a recent increase in interest in the use of medicinal and phytotherapeutic plants. Objective: to verify the effect of ethanolic extracts from different parts of fruits of two species of the genus Syzygium, on glucose and lipid levels in the blood, using animal models. Results: the bark extract of the seeds of S. cumini (Lamarck) Skeels proved to be effective in reducing blood glucose levels. This same extract was also effective in lowering blood cholesterol levels. The extract from the seed nuclei of S. cumini (Lamarck) Skeels and S. paniculatum(Gaertn) were effective in reducing blood triglyceride levels. Extracts from all parts of the fruits of S. cumini (Lamarck) Skeels and of the seed nuclei of S. panic-ulatum (Gaertn) prevented weight gain in the animals. Conclusion: in general, the seed extract of both species showed a direct influence on the parameters and characteristics under study.
{"title":"Hypoglycemic and Antihyperlipidemic effects of Syzygium cumini (Lamarck) Skeels and Syzygium paniculatum (Gaertn.)","authors":"R. J. Pereira, M. Cardoso, M. A. Andrade, R. J. Pereira","doi":"10.15446/rcciquifa.v50n3.90724","DOIUrl":"https://doi.org/10.15446/rcciquifa.v50n3.90724","url":null,"abstract":"Introduction: there is a recent increase in interest in the use of medicinal and phytotherapeutic plants. Objective: to verify the effect of ethanolic extracts from different parts of fruits of two species of the genus Syzygium, on glucose and lipid levels in the blood, using animal models. Results: the bark extract of the seeds of S. cumini (Lamarck) Skeels proved to be effective in reducing blood glucose levels. This same extract was also effective in lowering blood cholesterol levels. The extract from the seed nuclei of S. cumini (Lamarck) Skeels and S. paniculatum(Gaertn) were effective in reducing blood triglyceride levels. Extracts from all parts of the fruits of S. cumini (Lamarck) Skeels and of the seed nuclei of S. panic-ulatum (Gaertn) prevented weight gain in the animals. Conclusion: in general, the seed extract of both species showed a direct influence on the parameters and characteristics under study.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"2022 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73849385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2022-02-04DOI: 10.15446/rcciquifa.v50n3.100227
Romulo Pereira De Moura Sousa, Daniele de Figuerêdo Silva, Neuza Maria Cavalcante Oliveira, Zélia Braz Vieira Da Silva Pontes, Hermes Diniz Neto, Laísa Vilar Cordeiro, Pedro Thiago Ramalho de Figueiredo, Rafael Farias de Oliveira, Helivaldo Diógenes da Silva Souza, P. de Athayde Filho, E. de Oliveira Lima
Introduction: invasive candidiasis is related to high rates of morbidity and mortality. There are few classes of drugs available for the treatment of this type of infection and the index of resistant strains is increasing. Such circumstances highlight that the search for new pharmacotherapeutic alternatives is increasingly necessary. This study investigated 2-Bromo-N-phenylacetamide, a substance whose antifungal activity has not yet been reported. Objective: to evaluate its activity against invasive candidiasis isolates, by determining the minimum inhibitory and fungicide concentrations. Meth-odology: molecular docking was performed to investigate the possible mechanism of action of the substance. The substance was also associated with fluconazole, to assess the viability of the combination in clinical practice. The minimum inhibitory concen-trations ranged between 4 to 32 μg/mL, and it acts in a fungicidal way. Results: molec-ular docking suggests that 2-Bromo-N-phenylacetamide possibly acts on the fungal plasma membrane. And the association of 2-Bromo-N-phenylacetamide with flucon-azole against resistant strains showed an indifferent effect. Conclusion: further studies should be carried out to elucidate the potential of this substance, which may become a future drug candidate to treat invasive candidiasis and other fungal infections.
简介:侵袭性念珠菌病与高发病率和死亡率有关。可用于治疗这类感染的药物种类很少，耐药菌株的指数正在增加。这种情况突出表明，寻找新的药物治疗方案是越来越必要的。本研究研究了2-溴- n -苯乙酰胺，一种抗真菌活性尚未报道的物质。目的:通过测定其最低抑菌浓度和杀菌剂浓度，评价其对侵袭性念珠菌分离株的抑菌活性。方法:进行分子对接，探讨该物质可能的作用机制。该物质还与氟康唑相关联，以评估该组合在临床实践中的可行性。最低抑菌浓度在4 ~ 32 μg/mL之间，具有一定的杀真菌作用。结果:分子对接提示2-溴- n -苯乙酰胺可能作用于真菌质膜。2-溴- n-苯乙酰胺与氟康唑联用对耐药菌株效果不显著。结论:该物质可能成为治疗侵袭性念珠菌病和其他真菌感染的候选药物，有待进一步研究。
{"title":"In silico and in vitro analysis of a new potential antifungal substance, 2-Bromo-Nphenylacetamide, against invasive candidiasis isolates","authors":"Romulo Pereira De Moura Sousa, Daniele de Figuerêdo Silva, Neuza Maria Cavalcante Oliveira, Zélia Braz Vieira Da Silva Pontes, Hermes Diniz Neto, Laísa Vilar Cordeiro, Pedro Thiago Ramalho de Figueiredo, Rafael Farias de Oliveira, Helivaldo Diógenes da Silva Souza, P. de Athayde Filho, E. de Oliveira Lima","doi":"10.15446/rcciquifa.v50n3.100227","DOIUrl":"https://doi.org/10.15446/rcciquifa.v50n3.100227","url":null,"abstract":"Introduction: invasive candidiasis is related to high rates of morbidity and mortality. There are few classes of drugs available for the treatment of this type of infection and the index of resistant strains is increasing. Such circumstances highlight that the search for new pharmacotherapeutic alternatives is increasingly necessary. This study investigated 2-Bromo-N-phenylacetamide, a substance whose antifungal activity has not yet been reported. Objective: to evaluate its activity against invasive candidiasis isolates, by determining the minimum inhibitory and fungicide concentrations. Meth-odology: molecular docking was performed to investigate the possible mechanism of action of the substance. The substance was also associated with fluconazole, to assess the viability of the combination in clinical practice. The minimum inhibitory concen-trations ranged between 4 to 32 μg/mL, and it acts in a fungicidal way. Results: molec-ular docking suggests that 2-Bromo-N-phenylacetamide possibly acts on the fungal plasma membrane. And the association of 2-Bromo-N-phenylacetamide with flucon-azole against resistant strains showed an indifferent effect. Conclusion: further studies should be carried out to elucidate the potential of this substance, which may become a future drug candidate to treat invasive candidiasis and other fungal infections.","PeriodicalId":21220,"journal":{"name":"Revista Colombiana de Ciencias Químico-Farmacéuticas","volume":"11 3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74559376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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