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A Case of Low Phosphorus Osteomalacia in a Young Woman 1例年轻女性低磷骨软化症
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8543
Wang Xing, Zhang Tao
Hypophosphorous osteomalacia (HO) is a rare metabolic disease. Due to hypophosphatemia and insufficient production of active vitamin D, the bone matrix can not be mineralized normally. Its clinical symptoms are atypical. It is generally manifested in bone pain and muscle weakness in different parts. With the progress of the disease, it is very easy to have osteoporosis, pathological fracture, bone deformity and damage to the function of other organs of the whole body. The etiology can be divided into primary and secondary according to the pathogenesis [1]. The primary is often caused by genetic factors, which can be divided into X-linked dominant low phosphorus osteomalacia (XLH) and autosomal dominant low phosphorus osteomalacia (ADHR). The secondary cause can be low phosphorus osteomalacia (TIO) caused by exposure to some drugs or heavy metals and tumors. This disease is rare in clinic, so clinicians have insufficient understanding of the disease and are prone to missed diagnosis or misdiagnosis. This paper reports a case of adult female with low phosphorus osteomalacia. The diagnosis, treatment and treatment are analyzed and discussed in order to provide reference for clinic.
低磷骨软化症(HO)是一种罕见的代谢性疾病。由于低磷血症和活性维生素D的产生不足,骨基质不能正常矿化。其临床症状不典型。一般表现为骨痛和不同部位的肌肉无力。随着病情的进展,很容易出现骨质疏松、病理性骨折、骨畸形以及对全身其他器官功能的损害。病因按发病机制可分为原发性和继发性。原发性骨软化症通常由遗传因素引起,可分为x连锁显性低磷骨软化症(XLH)和常染色体显性低磷骨软化症(ADHR)。次要原因可能是低磷骨软化症(TIO),由暴露于某些药物或重金属和肿瘤引起。本病临床罕见,临床医生对本病认识不足,容易漏诊或误诊。本文报告一例成年女性低磷骨软化症。对其诊断、治疗和治疗方法进行了分析和探讨,以期为临床提供参考。
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引用次数: 0
Formulation and Evaluation of Herbal Lipstick Containing Alkanet Root as a Natural Colorant 含天然碱根着色剂的草药口红配方及评价
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8545
T. Pavithra, B. Kumar, Anand Mouna, Soujanya Munegowda
From ancient time peoples were using lipstick, which was made by natural sources to protect and to increase the beauty of lips. Herbal lipstick contains pigments, antioxidants, waxes, oils, fragrance and preservatives. Alkanet root is used as natural source of red pigment in cosmetics, food and textile industries. Alkanet roots are traditionally used to treat aging, wounds, inflammation and herpes. The herbal lipstick was formulated and subjected to evaluation by different parameters like breaking, melting and, softening points, surface anomalies, aging and perfume stabilities, solubility test and pH. The herbal lipstick presents quintessential properties after application. It was concluded that the formulated herbal lipstick provides less side effects and further clinical investigation is required to assess for better efficacy.
从古代起,人们就开始使用天然原料制成的口红来保护和增加嘴唇的美丽。草药唇膏含有色素、抗氧化剂、蜡、油、香味和防腐剂。烷烃根是化妆品、食品和纺织工业中红色素的天然来源。Alkanet根传统上用于治疗衰老、伤口、炎症和疱疹。配制草药唇膏,并通过破碎、熔点、软化点、表面异常、老化和香味稳定性、溶解度测试和ph等参数进行评价。使用后,草药唇膏呈现出典型的性能。结果表明,该制剂的副作用较小,疗效有待进一步的临床研究。
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引用次数: 0
Applicability of Green Absorbents to Remove Lead (II) from Polluted Water: a Potential Low-cost Adsorbent 绿色吸附剂去除污染水中铅(II)的适用性:一种潜在的低成本吸附剂
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8546
F. Abouzeid, Sultanah Alshammery
The present work represent potential bio-sorbent (banana and pomegranate peel) in nano size range, with a view to for adsorption of lead(II) ions from aqueous solution. Dose, adsorbate concentration, pH, time, and temperature factors were investigated. The most favorable stipulations for Pb (II) adsorption are 50 mg /L as initial concentration, 0.2 g as pomegranate and banana peels mass and pH 5.5 and 5.23for banana and Pomegranate peel. Removal data obey the Langmuir model with qmax of 25.64 mg/g for banana and 41.66 mg/g for Pomegranate peel. The kinetics of removal process was fitted well by a second -order equation. It was observed that that the Pb (II) ion adsorption process on the both bio-sorbents is spontaneous process, endothermic for banana while exothermic for pomegranate peel. A distinct improvement in the adsorbent surface was noted after adsorption process which demonstrated via scanning electron microscope.
研究了香蕉皮和石榴皮等纳米级生物吸附剂对铅离子的吸附作用。考察了剂量、吸附质浓度、pH、时间、温度等因素。吸附Pb (II)的最佳条件为初始浓度为50 mg /L,石榴皮和香蕉皮质量为0.2 g,香蕉皮和石榴皮的pH分别为5.5和5.23。去除数据符合Langmuir模型,香蕉的qmax为25.64 mg/g,石榴皮的qmax为41.66 mg/g。用二阶方程很好地拟合了去除过程的动力学。结果表明,两种生物吸附剂对Pb (II)离子的吸附均为自发过程,对香蕉为吸热吸附,对石榴皮为放热吸附。扫描电镜观察到吸附过程后吸附剂表面有明显的改善。
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引用次数: 0
Improved Synthesis of the Anti-SARS-CoV-2 Investigational Agent (E)-N-(4-Cyanobenzylidene)-6-fluoro-3-hydroxypyrazine-2-carboxamide (Cyanorona-20) 抗sars - cov -2研究药物(E)- n -(4- cyanoboblidene)-6-fluoro-3-hydroxypyrazine-2-carboxamide (Cyanorona-20)的改进合成
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8555
A. Rabie
Medicinal chemistry scientists` efforts and trials to discover a very potent anticoronaviral medicine specifically effective against the current frightening virus, the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), are not over yet. Synthetic organic chemistry will remain one of the most important branches in the entire drug discovery science. (E)-N-(4-Cyanobenzylidene)-6-fluoro-3-hydroxypyrazine-2-carboxamide (Cyanorona-20), a newly-discovered favipiravir analog/ derivative, is one of the promising synthetic organic compounds that displayed very strong nanomolar potencies against this fatal coronavirus, reaching an anticoronaviral-2 EC50 of nearly 450 nM or 0.45 μM. This compound was found to act against the SARS-CoV-2 mainly through the powerful inhibition of the coronaviral RNA-dependent RNA polymerase (RdRp), via competitively occupying and locking this enzyme`s major catalytic active site pocket (the suggested primary mechanism of action). Cyanorona-20 is still under progressive investigation as an attempt to continue developing it as a prospective remedy for the coronavirus disease 2019 (COVID-19). However, the previous literature synthetic procedures of Cyanorona-20 were criticized for several reasons like the harsh handling, difficult separation, small yield, and low purity. Herein in this short-communication or technical-note article, more reproducible and efficient novel synthetic method for Cyanorona-20 compound is presented, in an effort to address almost all of the problems which were accompanying the preceding methods.
药物化学科学家的努力和试验还没有结束,他们正在努力发现一种非常有效的抗冠状病毒药物,专门针对当前可怕的病毒——严重急性呼吸综合征冠状病毒2 (SARS-CoV-2)。合成有机化学仍将是整个药物发现科学中最重要的分支之一。(E)- n -(4- cyanoboblidene)-6-fluoro-3-hydroxypyrazine-2-carboxamide (cyanorna -20)是一种新发现的favipiravir类似物/衍生物,是一种有前景的合成有机化合物之一,对这种致命的冠状病毒表现出很强的纳米摩尔效力,其抗冠状病毒-2 EC50接近450 nM或0.45 μM。研究发现,该化合物对SARS-CoV-2的作用主要是通过竞争性地占据和锁定该酶的主要催化活性位点袋,从而对冠状病毒RNA依赖性RNA聚合酶(RdRp)产生强大的抑制作用(这是建议的主要作用机制)。Cyanorona-20仍在逐步研究中,试图继续将其开发为2019冠状病毒病(COVID-19)的前瞻性治疗药物。然而,以往文献中对Cyanorona-20的合成工艺存在操作粗糙、分离困难、收率小、纯度低等缺点。在这篇简短的技术笔记文章中,我们提出了一种重现性更好、效率更高的氰-20化合物的新合成方法,试图解决前面方法所伴随的几乎所有问题。
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引用次数: 1
Application of Hydrothermal and Solvothermal Method in Synthesis of MoS2 水热和溶剂热法在二硫化钼合成中的应用
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8544
He Huang, Na Liu, Xueying Wang, Mei Zhong, Xueli Huang
Hydrothermal and solvothermal method were considered as the effective methods for preparation of MoS2 nanomaterials. The current researches of MoS2 mainly concerned on electrical properties, the research of reaction system was relatively less. In this paper, synthesis system of MoS2 was elaborated from precursor, solution, reductant, sulfurizing agent, additive and pH regulator. The application of multifunctional raw materials can greatly simplify reaction system. This provided a reference for the application of hydrothermal and solvothermal method in preparation of MoS2.
水热法和溶剂热法被认为是制备二硫化钼纳米材料的有效方法。目前对二硫化钼的研究主要集中在电学性质方面,对其反应体系的研究相对较少。本文阐述了由前驱体、溶液、还原剂、硫化剂、添加剂和pH调节剂组成的二硫化钼合成体系。多功能原料的应用可以大大简化反应体系。为水热法和溶剂热法在二硫化钼制备中的应用提供了参考。
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引用次数: 0
Electrode Processes of 1,2,4-benzenetriol in Different non-aqueous Solvents 1,2,4-苯三醇在不同非水溶剂中的电极过程
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8541
L. Kiss
The electrooxidation of 1,2,4-benzenetriol was studied in different non-aqueous solvents. The results showed that the studied substance can be oxidized in several ways on the electrode surface due to the favourable positions of hydroxyl groups (similarly to hydroquinone, resorcinol and catechol). In most cases one anodic peak appeared involving all possible electrode processes. The concentration dependence of voltammetric peak currents using platinum macroelectrode showed nonlinearity attributable to the 1,3-oxidation similarly to resorcinol leading to partial deactivation. Appearance of more peaks indicated the weak deactivation at higher concentrations in acetonitrile and nitrobenzene. At higher concentration the microelectrode became deactivated as in the successive scans the currents declined continuously reinforcing the existence of resorcinol pathway.
研究了1,2,4-苯三醇在不同非水溶剂中的电氧化反应。结果表明,由于羟基的有利位置(类似于对苯二酚、间苯二酚和儿茶酚),所研究的物质可以在电极表面以多种方式氧化。在大多数情况下,一个阳极峰出现,涉及所有可能的电极过程。铂大电极伏安峰值电流的浓度依赖性与间苯二酚的1,3氧化相似,呈现非线性,导致部分失活。出现较多的峰表明在较高浓度的乙腈和硝基苯中失活较弱。在较高的浓度下,微电极变得失活,因为在连续的扫描中,电流不断下降,加强了间苯二酚途径的存在。
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引用次数: 0
Review on Molecular Cross-talk of Biofilm Producing Mechanisms of Staphylococcus aureus 金黄色葡萄球菌生物膜生成机制的分子串扰研究进展
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8556
P. Verma, Krishan Kumar, M. Verma, Aruna Dubey
Here the review converses the `molecular cross-talk` of biofuel production mechanisms for Staphylococcus aureus. Staphylococcus aureus is a leading cause of bacterial infections globally in both healthcare and community settings. The succes of this bacterium is the of an expansive repertoire of virulence factors in combination with acquired antibiotic resistance and propensity for biofilm formation. S. aureus leverages these factors to adapt to and subvert the host immune response. With the burgeoning fiels of immunometabolism, is has become clear that the metabolic program of leukocytes dictates their inflammatory status and overall effectiveness is clearing an infection. The treatment of S. aureus infections become complicated due to the capacity of S. aureus �multidrug-resistant� occurs because of biofilm formationon the surfaces depending on biotic and abiotic factors, genetic factors, and numerous environmental, which vary from species to species. A broad range of molecular phenomenon contributes a high range of recalcitrance that is insisting on the biofilm formation. The previous published literature illustrated that all strains of Staphylococcal sp. contain the �ica locus� and several can form biofilms in vitro condition. Absences of �ica locus� results diminish of capability to produce biofuels, along with `PIA gene`, or mediate `N-acetyl glucosaminyl transferase activity� in vitro condition.
本文综述了金黄色葡萄球菌生物燃料生产机制的“分子串扰”。金黄色葡萄球菌是全球卫生保健和社区环境中细菌感染的主要原因。这种细菌的成功是广泛的毒力因子与获得性抗生素耐药性和生物膜形成倾向相结合的结果。金黄色葡萄球菌利用这些因子来适应和破坏宿主的免疫反应。随着免疫代谢领域的蓬勃发展,人们已经清楚地认识到白细胞的代谢程序决定了它们的炎症状态和清除感染的总体有效性。金黄色葡萄球菌感染的治疗变得复杂,因为金黄色葡萄球菌的多重耐药能力是由于生物和非生物因素、遗传因素和各种环境因素在表面形成的生物膜而产生的,这些因素因物种而异。广泛的分子现象对生物膜的形成有很大的阻力。先前发表的文献表明,所有葡萄球菌菌株都含有“位点”,其中一些菌株在体外条件下可以形成生物膜。缺少“ica基因座”导致生物燃料的生产能力下降,以及“PIA基因”,或在体外条件下调节“n -乙酰氨基葡萄糖转移酶活性”。
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引用次数: 0
Mathematical Model for Predicting the Development of Two-Phase Flow in a Horizontal Pipe 水平管内两相流发展预测的数学模型
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8554
Safa S. Ibrahim, L. Abdulkareem, R. Mahmood
Prediction of the flow pattern is a central problms in multi-phase flow analysis. It is a vital point for researchers to accurately predict which flow pattern category types will occur at different flow rates. For this purpose, a mathematical model using the MATLAB (R2017b) computer program is developed for the prediction of gas-liquid two-phase flow patterns in a horizontal pipe with an inner diameter of 30mm under standard conditions. The properties of the air-water two-phase, the pipe geometry, and the flow rates of phases are defined to initiate the operating conditions. The mass flow rates of air and water changed from 0.002 to 0.004 kg/s and 0.672 to 1.334 kg/s, respectively. The impact of properties of the fluid and pipe diameters on two-phase flow configuration is considered to predict the impact of fluid properties on the flow pattern. The findings indicate that as the mass flux increases, the pipe diameters decrease, affecting the configuration of the flow pattern types. The mathematical model�s predicted results are validated by comparing with previous studies. In addition, good agreement is obtained when the predicted results are compared to the ongoing experiment of this research.
流型预测是多相流分析中的一个核心问题。准确预测在不同流量下会出现哪些流型类型是研究人员的一个关键问题。为此,利用MATLAB (R2017b)计算机程序建立数学模型,预测标准条件下内径30mm水平管内气液两相流的流型。定义了空气-水两相的性质、管道的几何形状和两相的流量来启动操作条件。空气和水的质量流量分别为0.002 ~ 0.004 kg/s和0.672 ~ 1.334 kg/s。考虑了流体性质和管径对两相流形态的影响,以预测流体性质对流型的影响。结果表明:随着质量通量的增大,管径减小,影响了流型类型的配置;通过与前人研究的比较,验证了数学模型的预测结果。此外,将预测结果与本研究正在进行的实验进行了比较,得到了很好的一致性。
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引用次数: 0
CONTENTS Nr. 4 / 2022
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8540
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引用次数: 0
Biochar as a Sustainable Product for the Removal of Odor Emissions - Mini Literature Review 生物炭作为一种可持续的去除气味排放物的产品-小型文献综述
Q2 Materials Science Pub Date : 2022-10-31 DOI: 10.37358/rc.22.4.8557
�ukasz Sobol, A. Dyjakon
Odors are considered as one of the most important environmental problems that may adversely influence the quality of life of people affected by their interaction. Due to the multiple sources of emissions, combined with the abundance of chemical compounds classified odor nuisance, new methods of reducing odor emissions are sought while maintaining environmental neutrality. One potential option is to use biochar, a sustainable, carbonized solid product resulting from the thermo-chemical treatment of biomass and/or organic waste. Due to its valuable properties (in particular, high specific surface area, and microporous structure), this material can be used for sorption purposes. Although the issue of using biochar to remove odor emissions is relatively new, in recent years new research directions have been undertaken to determine the sorption efficiency of biochar not only as a direct adsorbent but also in alternative applications. Therefore, this paper aimed to review the most important directions of biochar management in the removal of odor-causing compounds and to highlight the current advances undertaken in this direction. It was distinguished that biochar can enhance odor mitigation by being an additive to compost, a biofiltration medium, a direct adsorbent, a soil additive, a substrate for the production of the odor-absorbing product, a dietary supplement, and a biocover. However, further research is needed to strengthen the range of greater use of biochar in practice.
气味被认为是最重要的环境问题之一,可能会对受其影响的人们的生活质量产生不利影响。由于多重排放源,结合丰富的化合物分类气味滋扰,在保持环境中性的同时寻求减少气味排放的新方法。一个潜在的选择是使用生物炭,这是一种可持续的碳化固体产品,由生物质和/或有机废物的热化学处理产生。由于其宝贵的性质(特别是高比表面积和微孔结构),该材料可用于吸附目的。虽然使用生物炭去除气味排放的问题相对较新,但近年来已经开展了新的研究方向,以确定生物炭不仅作为直接吸附剂而且作为替代应用的吸附效率。因此,本文旨在综述生物炭管理在去除恶臭化合物方面最重要的方向,并重点介绍目前在这一方向上所取得的进展。研究表明,生物炭可以作为堆肥添加剂、生物过滤介质、直接吸附剂、土壤添加剂、生产吸臭产品的基质、膳食补充剂和生物覆盖物来增强气味缓解。然而,需要进一步的研究来扩大生物炭在实践中的广泛使用范围。
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引用次数: 2
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