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La cardiotoxicidad de las antraciclinas se asocia a alteraciones en la energética de la miosina cardiaca 蒽环素的心脏毒性与心脏肌凝素能量的改变有关
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-11-01 Epub Date: 2025-03-17 DOI: 10.1016/j.recesp.2025.02.001
Danielle Medina-Hernández , Carlos Galán-Arriola , Javier Sánchez-González , Julien Ochala , Borja Ibáñez
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引用次数: 0
Resusci Anne
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-11-01 Epub Date: 2025-05-21 DOI: 10.1016/j.recesp.2025.05.005
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引用次数: 0
Diferencias según el sexo en la anatomía de la insuficiencia mitral y resultados de la reparación percutánea de borde a borde 二尖瓣缺损的性别解剖差异和边缘到边缘经皮修复的结果
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-11-01 Epub Date: 2025-03-21 DOI: 10.1016/j.recesp.2025.01.024
Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Estefanía Fernández-Peregrina , Dabit Arzamendi
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引用次数: 0
Registro español de hemodinámica y cardiología intervencionista. XXXIV informe oficial de la Asociación de Cardiología Intervencionista de la Sociedad Española de Cardiología (1990-2024) 血液动力学和介入心脏病学的西班牙注册。西班牙心脏病学会介入心脏病学会第三十四次正式报告(1990-2024年)
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-11-01 Epub Date: 2025-07-10 DOI: 10.1016/j.recesp.2025.07.003
Teresa Bastante , Dabit Arzamendi , Javier Martín-Moreiras , Ana Belén Cid-Álvarez , en representación de la ACI-SEC

Introduction and objectives

This report presents the 2024 activity data from the Interventional Cardiology Association of the Spanish Society of Cardiology (ACI-SEC).

Methods

All interventional cardiology laboratories in Spain were invited to complete an online survey. Data analysis was conducted by an external company and then reviewed and presented by the ACI-SEC board.

Results

A total of 118 hospitals participated, with a marked increase in the number of catheterization laboratories. The number of diagnostic procedures rose by 3.6%. Percutaneous coronary interventions (PCI) also increased. Although PCI volumes grew compared with 2023, the trend toward a reduction in the number of stents used was confirmed, with greater use of drug-coated balloons both as standalone treatment and in hybrid strategies (14.3% of PCIs involved drug-coated balloons). Overall, the use of intracoronary diagnostic techniques increased, with 10.6% of PCIs guided by intracoronary imaging. Plaque modification techniques also continued to grow. Primary PCI increased slightly and remained the predominant treatment for myocardial infarction (98%). Structural interventions continued to expand, with substantial growth in transcatheter aortic valve implantation, percutaneous edge-to-edge mitral repair, tricuspid interventions, and left atrial appendage closure. Interventional treatment for acute pulmonary embolism increased again in 2024, especially with dedicated devices.

Conclusions

The 2024 Spanish cardiac catheterization and interventional cardiology registry showed overall growth in all procedures, both coronary and structural.
本报告介绍了西班牙心脏病学会介入心脏病学会(ACI-SEC) 2024年的活动数据。方法邀请西班牙所有介入心脏病实验室完成在线调查。数据分析由外部公司进行,然后由ACI-SEC董事会进行审查和提交。结果共有118家医院参与,导尿实验室数量明显增加。诊断程序的数量增加了3.6%。经皮冠状动脉介入治疗(PCI)也有所增加。尽管PCI容量与2023年相比有所增加,但支架使用数量减少的趋势得到证实,药物包被球囊作为独立治疗和混合策略的使用更多(14.3%的PCI涉及药物包被球囊)。总体而言,冠状动脉内诊断技术的使用增加,10.6%的pci由冠状动脉内成像引导。斑块修饰技术也在继续发展。首次PCI治疗略有增加,仍然是心肌梗死的主要治疗方法(98%)。结构性干预继续扩大,经导管主动脉瓣置入术、经皮二尖瓣边缘修复术、三尖瓣介入术和左心房附件闭合术的数量大幅增加。2024年,急性肺栓塞的介入治疗再次增加,特别是使用专用设备。2024年西班牙心导管和介入心脏病学登记显示,所有手术,包括冠状动脉和结构手术,都有所增长。
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引用次数: 0
Ecocardiografía avanzada y análisis de conglomerados para identificar fenogrupos de insuficiencia tricuspídea secundaria con diferente riesgo 高级超声心动图和聚类分析,以识别具有不同风险的继发性三足功能不全的表型群
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-28 DOI: 10.1016/j.recesp.2025.02.005
Luigi P. Badano , Marco Penso , Michele Tomaselli , Kyu Kim , Alexandra Clement , Noela Radu , Geu-Ru Hong , Diana R. Hădăreanu , Alexandra Buta , Caterina Delcea , Samantha Fisicaro , Gianfranco Parati , Chi Young Shim , Denisa Muraru

Introduction and objectives

Significant secondary tricuspid regurgitation (STR) is associated with poor prognosis, but its heterogeneity makes predicting patient outcomes challenging. Our objective was to identify STR prognostic phenogroups.

Methods

We analyzed 758 patients with moderate-to-severe STR: 558 (74 ± 14 years, 55% women) in the derivation cohort and 200 (73 ± 12 years, 60% women) in the external validation cohort. The primary endpoint was a composite of heart failure hospitalization and all-cause mortality.

Results

We identified 3 phenogroups. The low-risk phenogroup (2-year event-free survival 80%, 95%CI, 74%-87%) had moderate STR, preserved right ventricular (RV) size and function, and a moderately dilated but normally functioning right atrium. The intermediate-risk phenogroup (HR, 2.20; 95%CI, 1.44-3.37; P < .001) included older patients with severe STR, and a mildly dilated but uncoupled RV. The high-risk phenogroup (HR, 4.67; 95%CI, 3.20-6.82; P < .001) included younger patients with massive-to-torrential tricuspid regurgitation, as well as severely dilated and dysfunctional RV and right atrium. Multivariable analysis confirmed the clustering as independently associated with the composite endpoint (HR, 1.40; 95%CI, 1.13-1.70; P = .002). A supervised machine learning model, developed to assist clinicians in assigning patients to the 3 phenogroups, demonstrated excellent performance both in the derivation cohort (accuracy = 0.91, precision = 0.91, recall = 0.91, and F1 score = 0.91) and in the validation cohort (accuracy = 0.80, precision = 0.78, recall = 0.78, and F1 score = 0.77).

Conclusions

The unsupervised cluster analysis identified 3 risk phenogroups, which could assist clinicians in developing more personalized treatment and follow-up strategies for STR patients.
重要的继发性三尖瓣反流(STR)与不良预后相关,但其异质性使得预测患者预后具有挑战性。我们的目的是确定STR预后表型。方法对758例中重度STR患者进行分析:衍生队列558例(74±14岁,55%为女性),外部验证队列200例(73±12岁,60%为女性)。主要终点是心力衰竭住院和全因死亡率的综合。结果共鉴定出3个表型组。低风险表型组(2年无事件生存率80%,95%CI, 74%-87%)有中度STR,保留右心室(RV)大小和功能,中度扩张但功能正常的右心房。中危表型组(HR, 2.20; 95%CI, 1.44-3.37; P < .001)包括严重STR的老年患者和轻度扩张但未耦合的RV。高危表型组(HR, 4.67; 95%CI, 3.20-6.82; P < .001)包括年轻的三尖瓣大量到剧烈反流的患者,以及严重扩张和功能不全的右心室和右心房。多变量分析证实聚类与复合终点独立相关(HR, 1.40; 95%CI, 1.13-1.70; P = 0.002)。为了帮助临床医生将患者分配到3个表型组,开发了一个监督机器学习模型,该模型在衍生队列(准确性= 0.91,精度= 0.91,召回率= 0.91,F1评分= 0.91)和验证队列(准确性= 0.80,精度= 0.78,召回率= 0.78,F1评分= 0.77)中都表现出色。结论无监督聚类分析确定了3个风险表型,有助于临床医生为STR患者制定更个性化的治疗和随访策略。
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引用次数: 0
Preservación apical en el ecocardiograma de esfuerzo por sospecha de amiloidosis cardiaca 怀疑有心脏淀粉样变的力量超声心动图的顶端保存
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-21 DOI: 10.1016/j.recesp.2025.01.017
Jesús Peteiro , Marina Combarro , Gonzalo Barge-Caballero , Alberto Bouzas-Mosquera , José Larrañaga-Moreira , José M. Vázquez-Rodríguez
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引用次数: 0
Identificación de fenotipos en la insuficiencia cardiaca con fracción de eyección conservada a partir de 8.161 pacientes de 3 cohortes españolas 从3个西班牙队列的8161名患者中保留射精分数的心力衰竭表型鉴定
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-10-01 Epub Date: 2025-03-15 DOI: 10.1016/j.recesp.2025.02.019
Òscar Miró , Olivier Peyrony , Joan Carles Trullàs , Aitor Alquézar-Arbé , Julio Núñez , Pedro López-Ayala , Javier Jacob , Héctor Bueno , Manuel Montero-Pérez-Barquero , José Carlos Arévalo-Lorido , Rafael de la Espriella , Gema Miñana , Juan Sanchis , Pere Llorens

Introduction and objectives

To identify phenotypes in heart failure with preserved ejection fraction (HFpEF), compare mortality, and investigate whether treatments have different effects according to phenotype.

Methods

We performed a secondary analysis of 8161 patients with HFpEF included in Spanish cardiology (INCLIVA), internal medicine (RICA), and emergency (EAHFE) registries. Phenotypic clusters based on 16 baseline characteristics were identified using latent class analysis. We analyzed crude and treatment-adjusted 1-year survival, the associations between each treatment and mortality, and their interactions with phenotype.

Results

We identified 4 distinct clusters. One-year mortality was 18.7%. Cluster 4 (younger women with a valvular heart disease phenotype) had the lowest mortality (13.7%; reference category), which increased progressively in cluster 2 (cardiometabolic phenotype; mortality: 15.7%; adjusted HR, 1.28; 95%CI, 1.06-1.54), cluster 3 (very elderly female phenotype; mortality: 20.4%; adjusted HR, 1.63; 95%CI, 1.40-1.90), and cluster 1 (male cardiorespiratory phenotype; mortality: 24.0%; adjusted HR, 1.81; 95%CI, 1.53-2.13). The results were very similar when each registry was analyzed individually. Treatment with renin-angiotensin system inhibitors was associated with better survival in all clusters, beta-blockers were beneficial in cluster 1, and anticoagulants in cluster 4. However, none of the treatments showed a differential association with prognosis according to phenotype.

Conclusions

This study defines 4 HFpEF phenotypes with significantly different prognoses. Among the treatments analyzed, only renin-angiotensin system inhibitors seemed to have a generalized survival benefit, and none demonstrated a differential effect based on phenotype.
前言和目的确定具有保留射血分数(HFpEF)的心力衰竭的表型,比较死亡率,并研究治疗是否根据表型有不同的效果。方法:我们对8161例HFpEF患者进行了二次分析,这些患者分别来自西班牙心脏病学(INCLIVA)、内科(RICA)和急诊(EAHFE)登记处。基于16个基线特征的表型聚类通过潜在类分析确定。我们分析了粗生存率和治疗调整后的1年生存率,每种治疗与死亡率之间的关系,以及它们与表型的相互作用。结果鉴定出4个不同的聚类。一年死亡率为18.7%。第4类(有瓣膜病表型的年轻女性)的死亡率最低(13.7%,参考类别),在第2类(心脏代谢表型,死亡率:15.7%,校正HR, 1.28, 95%CI, 1.06-1.54)、第3类(非常老年女性表型,死亡率:20.4%,校正HR, 1.63, 95%CI, 1.40-1.90)和第1类(男性心肺表型,死亡率:24.0%,校正HR, 1.81, 95%CI, 1.53-2.13)中死亡率逐渐增加。当单独分析每个注册表时,结果非常相似。肾素-血管紧张素系统抑制剂治疗与所有组的更好生存率相关,β受体阻滞剂在组1中有益,抗凝剂在组4中有益。然而,根据表型,没有一种治疗显示出与预后的差异关联。结论本研究定义了4种具有显著预后差异的HFpEF表型。在分析的治疗方法中,只有肾素-血管紧张素系统抑制剂似乎具有普遍的生存益处,没有一种显示出基于表型的差异效应。
{"title":"Identificación de fenotipos en la insuficiencia cardiaca con fracción de eyección conservada a partir de 8.161 pacientes de 3 cohortes españolas","authors":"Òscar Miró ,&nbsp;Olivier Peyrony ,&nbsp;Joan Carles Trullàs ,&nbsp;Aitor Alquézar-Arbé ,&nbsp;Julio Núñez ,&nbsp;Pedro López-Ayala ,&nbsp;Javier Jacob ,&nbsp;Héctor Bueno ,&nbsp;Manuel Montero-Pérez-Barquero ,&nbsp;José Carlos Arévalo-Lorido ,&nbsp;Rafael de la Espriella ,&nbsp;Gema Miñana ,&nbsp;Juan Sanchis ,&nbsp;Pere Llorens","doi":"10.1016/j.recesp.2025.02.019","DOIUrl":"10.1016/j.recesp.2025.02.019","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>To identify phenotypes in heart failure with preserved ejection fraction (HFpEF), compare mortality, and investigate whether treatments have different effects according to phenotype.</div></div><div><h3>Methods</h3><div>We performed a secondary analysis of 8161 patients with HFpEF included in Spanish cardiology (INCLIVA), internal medicine (RICA), and emergency (EAHFE) registries. Phenotypic clusters based on 16 baseline characteristics were identified using latent class analysis. We analyzed crude and treatment-adjusted 1-year survival, the associations between each treatment and mortality, and their interactions with phenotype.</div></div><div><h3>Results</h3><div>We identified 4 distinct clusters. One-year mortality was 18.7%. Cluster 4 (younger women with a valvular heart disease phenotype) had the lowest mortality (13.7%; reference category), which increased progressively in cluster 2 (cardiometabolic phenotype; mortality: 15.7%; adjusted HR, 1.28; 95%<span>C</span>I, 1.06-1.54), cluster 3 (very elderly female phenotype; mortality: 20.4%; adjusted HR, 1.63; 95%CI, 1.40-1.90), and cluster 1 (male cardiorespiratory phenotype; mortality: 24.0%; adjusted HR, 1.81; 95%CI, 1.53-2.13). The results were very similar when each registry was analyzed individually. Treatment with renin-angiotensin system inhibitors was associated with better survival in all clusters, beta-blockers were beneficial in cluster 1, and anticoagulants in cluster 4. However, none of the treatments showed a differential association with prognosis according to phenotype.</div></div><div><h3>Conclusions</h3><div>This study defines 4 HFpEF phenotypes with significantly different prognoses. Among the treatments analyzed, only renin-angiotensin system inhibitors seemed to have a generalized survival benefit, and none demonstrated a differential effect based on phenotype.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 896-905"},"PeriodicalIF":5.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Registro español de trasplante cardiaco. XXXVI informe oficial de la Asociación de Insuficiencia Cardiaca de la Sociedad Española de Cardiología 西班牙心脏移植登记。西班牙心脏病学会心脏衰竭协会第三十六届正式报告
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-10-01 Epub Date: 2025-05-05 DOI: 10.1016/j.recesp.2025.04.010
Francisco González-Vílchez , Luis Almenar-Bonet , Manuel Gómez-Bueno , María G. Crespo-Leiro , Manuel Cobo-Belaustegui , Manuel Crespín-Crespín , Carlos Ortiz-Bautista , Juan F. Delgado-Jiménez , Marta de Antonio-Ferrer , José Manuel Sobrino-Márquez , en representación de los Equipos Españoles de Trasplante Cardiaco , Miguel Llano-Cardenal , José Antonio Vázquez de Prada , Francisco Nistal-Herrera , Cristina Castrillo , Beatriz Díaz-Molina , Vanesa Alonso-Fernández , Cristina Fidalgo-Muñiz , Diego Rangel-Sousa , Antonio Grande-Trillo , Ferrán Gran-Ipiña

Introduction and objectives

This report presents updated data on heart transplants in Spain, including procedures carried out in 2024. It reviews trends over the past decade (2015-2024) in donor and recipient characteristics, surgical techniques, immunosuppression strategies, and survival rates.

Methods

Data were drawn from the Spanish heart transplant registry, which is updated annually. The analysis includes 347 transplants performed in 2024, as well as procedures from 2015 to 2023 (n = 2721).

Results

In 2024, the number of heart transplants increased by 6.8% compared with 2023. There were no significant changes in recipient age or sex, but the proportion of urgent transplants rose to 47.0%. Use of circulatory support devices increased, particularly extracorporeal membrane oxygenation. The average donor age showed a slight increase in 2024, although the long-term trend remained downward. Donation after circulatory death accounted for 29.1% of transplants in 2024. One-year survival rates improved, reaching 85.2% for transplants performed between 2021 and 2023.

Conclusions

The number of heart transplants continued to grow, nearing historic highs, largely due to the expansion of donation after circulatory death. Improved 1-year survival reflects the maturity of transplant programs, advances in surgical and medical management, and better pretransplant conditions in recipients.
本报告介绍了西班牙心脏移植的最新数据,包括2024年进行的手术。它回顾了过去十年(2015-2024)在供体和受体特征、手术技术、免疫抑制策略和生存率方面的趋势。方法数据来自每年更新的西班牙心脏移植登记处。该分析包括2024年进行的347例移植手术,以及2015年至2023年的手术(n = 2721)。结果2024年心脏移植数量较2023年增长6.8%。受者的年龄和性别没有明显变化,但紧急移植的比例上升到47.0%。循环支持装置的使用增加,特别是体外膜氧合。尽管长期趋势仍然是下降的,但2024年平均供体年龄略有增加。2024年循环死亡后捐赠占移植的29.1%。2021年至2023年间进行的移植手术的一年存活率达到85.2%。结论心脏移植数量持续增长,接近历史最高水平,主要是由于循环死亡后捐赠的扩大。1年生存率的提高反映了移植方案的成熟、手术和医疗管理的进步以及移植前受者状况的改善。
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引用次数: 0
Rabdomiosarcoma pleomórfico arterial pulmonar con invasión a mediastino 肺动脉多形性横纹肌肉瘤
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-10-01 Epub Date: 2025-02-13 DOI: 10.1016/j.recesp.2025.02.007
Víctor Manuel López-Espinosa, Isabel Navarro-Pelayo Torres, Juan Emilio Alcalá-López
{"title":"Rabdomiosarcoma pleomórfico arterial pulmonar con invasión a mediastino","authors":"Víctor Manuel López-Espinosa,&nbsp;Isabel Navarro-Pelayo Torres,&nbsp;Juan Emilio Alcalá-López","doi":"10.1016/j.recesp.2025.02.007","DOIUrl":"10.1016/j.recesp.2025.02.007","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 927-928"},"PeriodicalIF":5.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impacto de la exclusión de accesos transapicales en los resultados por sexos del implante percutáneo de válvula aórtica: ¿una limitación metodológica? Respuesta 排除经脊柱进入对经皮主动脉瓣植入的性别结果的影响:方法论上的限制?答
IF 5.9 2区 医学 Q2 Medicine Pub Date : 2025-10-01 Epub Date: 2025-07-24 DOI: 10.1016/j.recesp.2025.06.007
Salvatore Brugaletta
{"title":"Impacto de la exclusión de accesos transapicales en los resultados por sexos del implante percutáneo de válvula aórtica: ¿una limitación metodológica? Respuesta","authors":"Salvatore Brugaletta","doi":"10.1016/j.recesp.2025.06.007","DOIUrl":"10.1016/j.recesp.2025.06.007","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Page 931"},"PeriodicalIF":5.9,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181346","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Revista espanola de cardiologia
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