Pub Date : 2025-03-21DOI: 10.1016/j.recesp.2025.02.003
Jens Wiebe , Constantin Kuna , Tareq Ibrahim , Sebastian Kufner , Isabella Hintz , Paul Justenhoven , Thorsten Kessler , Heribert Schunkert , Marco Valgimigli , Gert Richardt , Jola Bresha , Karl-Ludwig Laugwitz , Adnan Kastrati , Salvatore Cassese
Introduction and objectives
Long-term data after stenting of the left main coronary artery (LMCA) are scarce, especially regarding new-generation drug-eluting stents (DES). This analysis aimed to describe the 10-year clinical outcomes of patients who underwent percutaneous coronary intervention with different DES generations for LMCA disease.
Methods
Individual patient data from the randomized controlled ISAR-LEFT MAIN and ISAR-LEFT MAIN 2 trials were pooled and 10-year clinical follow-up was obtained. The Kaplan-Meier method was used to calculate event rates. The main endpoints of interest for this analysis were all-cause mortality, myocardial infarction, target lesion revascularization and definite stent thrombosis.
Results
A total of 1257 patients were included in this analysis, of which 650 patients were treated with new-generation DES and 607 with early-generation DES. At 10 years, the mortality rate was more than 40% in both groups. After statistical adjustment, 10-year mortality was significantly reduced in patients treated with new-generation DES compared with those treated with early-generation DES (HRadj, 0.78; 95%CI, 0.62-0.97). After 10 years, the risk of myocardial infarction (HRadj, 0.43; 95%CI, 0.23-0.80), target lesion revascularization (HRadj, 0.66; 95%CI, 0.49-0.89), and definite stent thrombosis (HRadj, 0.13, 95%CI, 0.04-0.49) was significantly reduced by new-generation DES compared with early-generation DES.
Conclusions
Patients undergoing percutaneous coronary intervention for LMCA disease have high 10-year mortality regardless of DES generation. The use of new-generation DES in patients with LMCA disease is associated with improved long-term clinical outcomes compared with early-generation DES.
{"title":"Resultados clínicos a 10 años tras el implante de SLF de primera o nueva generación en el tronco coronario izquierdo","authors":"Jens Wiebe , Constantin Kuna , Tareq Ibrahim , Sebastian Kufner , Isabella Hintz , Paul Justenhoven , Thorsten Kessler , Heribert Schunkert , Marco Valgimigli , Gert Richardt , Jola Bresha , Karl-Ludwig Laugwitz , Adnan Kastrati , Salvatore Cassese","doi":"10.1016/j.recesp.2025.02.003","DOIUrl":"10.1016/j.recesp.2025.02.003","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Long-term data after stenting of the left main coronary artery (LMCA) are scarce, especially regarding new-generation drug-eluting stents (DES). This analysis aimed to describe the 10-year clinical outcomes of patients who underwent percutaneous coronary intervention with different DES generations for LMCA disease.</div></div><div><h3>Methods</h3><div>Individual patient data from the randomized controlled ISAR-LEFT MAIN and ISAR-LEFT MAIN 2 trials were pooled and 10-year clinical follow-up was obtained. The Kaplan-Meier method was used to calculate event rates. The main endpoints of interest for this analysis were all-cause mortality, myocardial infarction, target lesion revascularization and definite stent thrombosis.</div></div><div><h3>Results</h3><div>A total of 1257 patients were included in this analysis, of which 650 patients were treated with new-generation DES and 607 with early-generation DES. At 10 years, the mortality rate was more than 40% in both groups. After statistical adjustment, 10-year mortality was significantly reduced in patients treated with new-generation DES compared with those treated with early-generation DES (HR<sub>adj</sub>, 0.78; 95%<span>C</span>I, 0.62-0.97). After 10 years, the risk of myocardial infarction (HR<sub>adj</sub>, 0.43; 95%CI, 0.23-0.80), target lesion revascularization (HR<sub>adj</sub>, 0.66; 95%CI, 0.49-0.89), and definite stent thrombosis (HR<sub>adj</sub>, 0.13, 95%CI, 0.04-0.49) was significantly reduced by new-generation DES compared with early-generation DES.</div></div><div><h3>Conclusions</h3><div>Patients undergoing percutaneous coronary intervention for LMCA disease have high 10-year mortality regardless of DES generation. The use of new-generation DES in patients with LMCA disease is associated with improved long-term clinical outcomes compared with early-generation DES.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 9","pages":"Pages 811-819"},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895211","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Factores de riesgo para progresión de la insuficiencia aórtica tras la reparación quirúrgica del aneurisma del seno de Valsalva. Análisis de 317 casos","authors":"Tianyu Chen , Jianzheng Cen , Shusheng Wen , Jimei Chen , Jian Zhuang , Xiaobing Liu","doi":"10.1016/j.recesp.2025.01.006","DOIUrl":"10.1016/j.recesp.2025.01.006","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 8","pages":"Pages 741-744"},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144713857","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.recesp.2025.01.023
Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Xavier Millán , Dabit Arzamendi
{"title":"Predictibilidad y tilting de dispositivo en la reparación mitral de borde a borde","authors":"Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Xavier Millán , Dabit Arzamendi","doi":"10.1016/j.recesp.2025.01.023","DOIUrl":"10.1016/j.recesp.2025.01.023","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 924-926"},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181352","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.recesp.2025.03.004
Alfonso Jurado-Román , José M. Montero-Cabezas
{"title":"Beneficio pronóstico de la revascularización percutánea de las oclusiones coronarias crónicas. Paradojas y contradicciones de un debate sin final","authors":"Alfonso Jurado-Román , José M. Montero-Cabezas","doi":"10.1016/j.recesp.2025.03.004","DOIUrl":"10.1016/j.recesp.2025.03.004","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 860-862"},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181404","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-21DOI: 10.1016/j.recesp.2025.01.024
Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Estefanía Fernández-Peregrina , Dabit Arzamendi
{"title":"Diferencias según el sexo en la anatomía de la insuficiencia mitral y resultados de la reparación percutánea de borde a borde","authors":"Chi-Hion Pedro Li , Lluís Asmarats , Albert Massó van Roessel , Helena Capellades , Estefanía Fernández-Peregrina , Dabit Arzamendi","doi":"10.1016/j.recesp.2025.01.024","DOIUrl":"10.1016/j.recesp.2025.01.024","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 11","pages":"Pages 1010-1012"},"PeriodicalIF":5.9,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369614","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.recesp.2025.01.005
Guillem Casas , Eduard Ródenas-Alesina , Javier Limeres , Clara Badia-Molins , José M. Larrañaga-Moreira , Jesús G. Mirelis , Javier Navarrete-Navarro , Jesús Martín-Jiménez , Juan E. Alcalá-López , Josefa González-Carrillo , Albert Teis , Rafaela Soler-Fernández , Gisela Teixidó-Turà , Laura Gutiérrez-García , Paula Fernández-Álvarez , Patricia Muñoz-Cabello , José A. Barrabés , Coloma Tirón , Julián Palomino-Doza , José Manuel García-Pinilla , José F. Rodríguez-Palomares
Introduction and objectives
Defining the probability of cardiomyopathy in individuals with excessive trabeculation of the left ventricle (ETLV) is an unmet clinical need. Our aims were: a) to describe the incidence and predictors of left ventricular ejection fraction (LVEF) decline and its correlation with major adverse cardiovascular events (MACE); and b) to identify prognostic factors in low-risk individuals.
Methods
Retrospective multicenter study in patients with ETLV and suspected cardiomyopathy. Two endpoints were analyzed: a) LVEF decline (> 10% absolute decrease in LVEF with LVEF < 50% at follow-up); and b) MACE, a composite of heart failure, ventricular arrhythmias, systemic embolisms, or cardiovascular mortality. Cardiovascular magnetic resonance core-lab analysis was performed in low-risk individuals (LVEF ≥ 50% and negative late gadolinium enhancement).
Results
A total of 530 patients were included, with a mean age of 44 ± 19 years and 44% were women. The mean LVEF was 49 ± 16%. Over a median echocardiographic follow-up of 4.2 years, 29 patients (6%) showed a decline in LVEF. Late gadolinium enhancement (P = .004) and baseline atrial fibrillation (P = .006) were independently associated with LVEF decline. During a subsequent clinical follow-up of 3.8 years, 106 patients (20%) experienced MACE. Factors that remained associated with MACE after adjustment were baseline LVEF (P < .001), LVEF decline (P = .022), baseline atrial fibrillation (P = .001), and QRS ≥ 120 ms (P = .009). Among low-risk individuals, left atrial strain correlated with outcomes and distinguished subclinical cardiomyopathy from physiological excessive trabeculation.
Conclusions
In ETLV, a decline in LVEF predicts cardiovascular events beyond baseline LVEF. In low-risk individuals, left atrial strain defines the probability of cardiomyopathy. A comprehensive assessment might provide valuable insights for differential diagnosis and risk stratification in this population.
{"title":"Deterioro de la fracción de eyección del ventrículo izquierdo y eventos cardiovasculares en la miocardiopatía con excesiva trabeculación: hacia la medicina de precisión","authors":"Guillem Casas , Eduard Ródenas-Alesina , Javier Limeres , Clara Badia-Molins , José M. Larrañaga-Moreira , Jesús G. Mirelis , Javier Navarrete-Navarro , Jesús Martín-Jiménez , Juan E. Alcalá-López , Josefa González-Carrillo , Albert Teis , Rafaela Soler-Fernández , Gisela Teixidó-Turà , Laura Gutiérrez-García , Paula Fernández-Álvarez , Patricia Muñoz-Cabello , José A. Barrabés , Coloma Tirón , Julián Palomino-Doza , José Manuel García-Pinilla , José F. Rodríguez-Palomares","doi":"10.1016/j.recesp.2025.01.005","DOIUrl":"10.1016/j.recesp.2025.01.005","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Defining the probability of cardiomyopathy in individuals with excessive trabeculation of the left ventricle (ETLV) is an unmet clinical need. Our aims were: <em>a)</em> to describe the incidence and predictors of left ventricular ejection fraction (LVEF) decline and its correlation with major adverse cardiovascular events (MACE); and <em>b)</em> to identify prognostic factors in low-risk individuals.</div></div><div><h3>Methods</h3><div>Retrospective multicenter study in patients with ETLV and suspected cardiomyopathy. Two endpoints were analyzed: <em>a)</em> LVEF decline (> 10% absolute decrease in LVEF with LVEF <<!--> <!-->50% at follow-up); and <em>b)</em> MACE, a composite of heart failure, ventricular arrhythmias, systemic embolisms, or cardiovascular mortality. Cardiovascular magnetic resonance core-lab analysis was performed in low-risk individuals (LVEF ≥<!--> <!-->50% and negative late gadolinium enhancement).</div></div><div><h3>Results</h3><div>A total of 530 patients were included, with a mean age of 44<!--> <!-->±<!--> <!-->19 years and 44% were women. The mean LVEF was 49<!--> <!-->±<!--> <!-->16%. Over a median echocardiographic follow-up of 4.2 years, 29 patients (6%) showed a decline in LVEF. Late gadolinium enhancement (<em>P<!--> </em>=<!--> <!-->.004) and baseline atrial fibrillation (<em>P<!--> </em>=<!--> <!-->.006) were independently associated with LVEF decline. During a subsequent clinical follow-up of 3.8 years, 106 patients (20%) experienced MACE. Factors that remained associated with MACE after adjustment were baseline LVEF (<em>P<!--> </em><<!--> <!-->.001), LVEF decline (<em>P</em> <!-->=<!--> <!-->.022), baseline atrial fibrillation (<em>P</em> <!-->=<!--> <!-->.001), and QRS ≥<!--> <!-->120<!--> <!-->ms (<em>P</em> <!-->=<!--> <!-->.009). Among low-risk individuals, left atrial strain correlated with outcomes and distinguished subclinical cardiomyopathy from physiological excessive trabeculation.</div></div><div><h3>Conclusions</h3><div>In ETLV, a decline in LVEF predicts cardiovascular events beyond baseline LVEF. In low-risk individuals, left atrial strain defines the probability of cardiomyopathy. A comprehensive assessment might provide valuable insights for differential diagnosis and risk stratification in this population.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 11","pages":"Pages 934-944"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.recesp.2025.02.021
Enrique Pérez-de la Sota, Andrea Eixerés-Esteve, Jorge Enrique Centeno-Rodríguez, María Jesús López-Gude, Christian Muñoz-Guijosa
{"title":"Implante de Impella por tronco braquiocefálico: una alternativa para soporte izquierdo en accesos axilares pequeños","authors":"Enrique Pérez-de la Sota, Andrea Eixerés-Esteve, Jorge Enrique Centeno-Rodríguez, María Jesús López-Gude, Christian Muñoz-Guijosa","doi":"10.1016/j.recesp.2025.02.021","DOIUrl":"10.1016/j.recesp.2025.02.021","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 12","pages":"Pages 1124-1126"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.recesp.2025.01.019
Marta Herrero-Brocal , Almudena Ureña , Juan M. Ruiz-Nodar
{"title":"Migración de un ateroma gravemente calcificado durante el TAVI","authors":"Marta Herrero-Brocal , Almudena Ureña , Juan M. Ruiz-Nodar","doi":"10.1016/j.recesp.2025.01.019","DOIUrl":"10.1016/j.recesp.2025.01.019","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 9","pages":"Pages 831-832"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144895213","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.recesp.2025.02.001
Danielle Medina-Hernández , Carlos Galán-Arriola , Javier Sánchez-González , Julien Ochala , Borja Ibáñez
{"title":"La cardiotoxicidad de las antraciclinas se asocia a alteraciones en la energética de la miosina cardiaca","authors":"Danielle Medina-Hernández , Carlos Galán-Arriola , Javier Sánchez-González , Julien Ochala , Borja Ibáñez","doi":"10.1016/j.recesp.2025.02.001","DOIUrl":"10.1016/j.recesp.2025.02.001","url":null,"abstract":"","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 11","pages":"Pages 1012-1014"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145369615","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-03-17DOI: 10.1016/j.recesp.2025.01.018
Luigi Gerra , Tommaso Bucci , Ho Man Lam , Marta Mantovani , Antonios A. Argyris , Muath Alobaida , Kully Sandhu , Joseph Mills , Giuseppe Boriani , Gregory Y.H. Lip
Introduction and objectives
Data on the impact of amyloidosis on outcomes after transcatheter aortic valve implantation (TAVI) are limited. The objective of this study was to evaluate the 1-year risk of adverse events post-TAVI in patients with amyloidosis.
Methods
Patients undergoing TAVI (between 2005 and 2023) were categorized into 2 groups based on the presence of amyloidosis. The primary outcome was the 1-year risk of a composite endpoint: heart failure (HF), ischemic stroke, pacemaker implantation, acute kidney injury, and all-cause death. Secondary outcomes assessed the individual components of the composite. Propensity score matching was used to balance the groups, and Cox regression was used to assess the risk of adverse outcomes associated with amyloidosis. Composite outcomes were analyzed for early (30-days) and long-term (30-days to 1 year) follow-up.
Results
Data from 589 TAVI patients with amyloidosis (mean age 78.9 ± 8.2 years, 31.9% female) were compared with 52 296 individuals without amyloidosis (mean age 78.1 ± 8.8 years, 40.3% female). After propensity score matching, patients with amyloidosis had a significantly higher 1-year risk of adverse events (HR, 1.27; 95%CI, 1.08-1.49). Specifically, patients with amyloidosis showed an increased risk of HF (HR, 1.37; 95%CI, 1.10-1.70). Stroke risk (HR, 1.67; 95%CI, 1.16–2.40) and pacemaker implantation (HR, 2.25; 95%CI, 1.15-4.41) were higher during long-term follow-up, while no differences were found for acute kidney injury or all-cause mortality between the 2 groups.
Conclusions
Among patients undergoing TAVI, those with amyloidosis are at a higher risk of adverse events, particularly HF, and have an increased risk of pacemaker implantation and stroke in the long-term.
{"title":"Impacto de la amiloidosis en los resultados tras el implante percutáneo de prótesis valvular aórtica","authors":"Luigi Gerra , Tommaso Bucci , Ho Man Lam , Marta Mantovani , Antonios A. Argyris , Muath Alobaida , Kully Sandhu , Joseph Mills , Giuseppe Boriani , Gregory Y.H. Lip","doi":"10.1016/j.recesp.2025.01.018","DOIUrl":"10.1016/j.recesp.2025.01.018","url":null,"abstract":"<div><h3>Introduction and objectives</h3><div>Data on the impact of amyloidosis on outcomes after transcatheter aortic valve implantation (TAVI) are limited. The objective of this study was to evaluate the 1-year risk of adverse events post-TAVI in patients with amyloidosis.</div></div><div><h3>Methods</h3><div>Patients undergoing TAVI (between 2005 and 2023) were categorized into 2 groups based on the presence of amyloidosis. The primary outcome was the 1-year risk of a composite endpoint: heart failure (HF), ischemic stroke, pacemaker implantation, acute kidney injury, and all-cause death. Secondary outcomes assessed the individual components of the composite. Propensity score matching was used to balance the groups, and Cox regression was used to assess the risk of adverse outcomes associated with amyloidosis. Composite outcomes were analyzed for early (30-days) and long-term (30-days to 1 year) follow-up.</div></div><div><h3>Results</h3><div>Data from 589 TAVI patients with amyloidosis (mean age 78.9<!--> <!-->±<!--> <!-->8.2 years, 31.9% female) were compared with 52 296 individuals without amyloidosis (mean age 78.1<!--> <!-->±<!--> <!-->8.8 years, 40.3% female). After propensity score matching, patients with amyloidosis had a significantly higher 1-year risk of adverse events (HR, 1.27; 95%CI, 1.08-1.49). Specifically, patients with amyloidosis showed an increased risk of HF (HR, 1.37; 95%CI, 1.10-1.70). Stroke risk (HR, 1.67; 95%CI, 1.16–2.40) and pacemaker implantation (HR, 2.25; 95%CI, 1.15-4.41) were higher during long-term follow-up, while no differences were found for acute kidney injury or all-cause mortality between the 2 groups.</div></div><div><h3>Conclusions</h3><div>Among patients undergoing TAVI, those with amyloidosis are at a higher risk of adverse events, particularly HF, and have an increased risk of pacemaker implantation and stroke in the long-term.</div></div>","PeriodicalId":21299,"journal":{"name":"Revista espanola de cardiologia","volume":"78 10","pages":"Pages 886-895"},"PeriodicalIF":5.9,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145181401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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