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Congenital myasthenic syndromes by Epsilon subunit mutations: Phenotypic profiles of 17 Algerian families. 由 Epsilon 亚基突变引起的先天性肌无力综合征:17 个阿尔及利亚家庭的表型特征。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-07 DOI: 10.1016/j.neurol.2024.09.007
M I Kediha, M Tazir, D Sternberg, B Eymard, L Ali Pacha

Background: Congenital myasthenic syndromes (CMS) are a heterogeneous group of rare genetic disorders. The acetyl choline receptor contains five subunits, with a predominance of mutations affecting the epsilon subunit gene called cholinergic receptor nicotinic epsilon (CHRNE) gene.

Objective: To study the clinical phenotype of 17 families with CHRNE gene mutations.

Methods: We report a series of 17 families with 22 affected patients carrying different mutations encoding CHRNE proteins.

Results: We studied their clinical and biological phenotypes, as well as their evolutionary profile and their response to the different therapies proposed. A phenotypic comparison was made between the families carrying the founding Maghrebian mutation and the other mutations found in this series.

Conclusion: The CHRNE gene mutations are the most frequent ones in CMS. The phenotypes reported in this study are heterogeneous, and can depend on the causative mutation.

背景:先天性肌无力综合征(CMS)是一组异质性的罕见遗传疾病。乙酰胆碱受体包含五个亚基,其中epsilon亚基基因(即胆碱能受体烟碱epsilon(CHRNE)基因)的突变占绝大多数:研究17个CHRNE基因突变家族的临床表型:方法:我们报告了一系列 17 个家族的 22 位患者,他们携带不同的 CHRNE 蛋白编码突变:结果:我们研究了这些患者的临床和生物学表型,以及他们的进化特征和对不同疗法的反应。我们对携带马格里布基因突变的家族与该系列中发现的其他基因突变家族进行了表型比较:结论:CHRNE 基因突变是 CMS 中最常见的突变。结论:CHRNE 基因突变是 CMS 中最常见的突变。本研究中报告的表型具有异质性,可能取决于致病突变。
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引用次数: 0
The “zebra sign” after a lumbar puncture 腰椎穿刺后的 "斑马征"。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.03.010
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引用次数: 0
Herpes simplex virus-2 meningo-encephalitis hiding a criminal case of fatal methylmercury poisoning 隐藏着致命甲基汞中毒刑事案件的单纯疱疹病毒-2脑膜脑炎。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.05.004
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引用次数: 0
Mindfulness in Parkinson's disease: A French national survey and a pilot intervention feasibility trial using the MBSR program (M-Park) 帕金森病的正念疗法:法国全国调查和使用 MBSR 计划(M-Park)的试点干预可行性试验。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.03.013
<div><h3>Background</h3><div><span>Non-pharmacological complementary interventions, particularly mind-body practices, are of growing importance in the management of Parkinson's disease (PD). Among these, </span>mindfulness<span><span> meditation seems particularly effective, especially on anxiety and depression symptoms. However, current knowledge on mindfulness standardized programs in PD is still limited, particularly in France. Aiming at improving this knowledge we designed the M-PARK study in two phases. Phase 1 consisted in a French national survey to explore expectations, needs and initiatives for </span>mindfulness meditation<span> for PD patients. Phase 2 was a clinical trial<span> with objectives to assess feasibility, acceptability and effects of a mindfulness (MBSR) program proposed to PD patients.</span></span></span></div></div><div><h3>Methods</h3><div><span>In phase 1, online questionnaires were addressed to members of a French PD patient's association (France Parkinson) and French MBSR<span> qualified instructors. In Phase 2, a clinical trial<span> involving 30 PD patients consisted of a standard MBSR program with two additional evaluation visits one month before and after the program. Data collection included a global clinical evaluation, assessment of depression and anxiety symptoms, sleep, pain and </span></span></span>quality of life<span> and a face-to-face interview for qualitative assessment of the acceptability and lived experience during the program. Three MBSR programs were proposed to three groups of ten patients: two were online due to the pandemic situation, one proposed to patients with no or minor fluctuations (group 1) and one for patients with slight to moderate fluctuations (group 2), and the last one face-to-face for patients with no or minor fluctuations (group 3).</span></div></div><div><h3>Results</h3><div>French survey: 209 responses were collected for the questionnaire sent to the members of the association France Parkinson; and 68 for the questionnaire sent to the instructors. Two-thirds of patients surveyed had heard of mindfulness meditation (66%), but were unaware of what this approach really consisted and how it could really help them. Few instructors (29%) had had to deal with patients with PD in their current practice. Yet 90% of patients surveyed indicated they were in favor of introducing this type of approach into their care.</div></div><div><h3>Clinical trial</h3><div><span>The results indicated that the program is feasible and acceptable both online and face-to-face for patients with PD. Among the 30 patients enrolled, 25 completed the program. No unwanted effects related to mindfulness meditation practice were observed. The results showed a statistically significant reduction in anxiety symptoms, depressive symptoms, and improvement in quality of life. Furthermore, no statistically significant change was measured for pain or sleep quality. There was no striking difference in results observed be
背景:在帕金森病(PD)的治疗过程中,非药物辅助干预措施,尤其是身心疗法的重要性与日俱增。其中,正念冥想似乎特别有效,尤其是对焦虑和抑郁症状。然而,目前有关帕金森病正念冥想标准化项目的知识仍然有限,尤其是在法国。为了增进这方面的知识,我们分两个阶段设计了 M-PARK 研究。第一阶段包括一项法国全国性调查,目的是了解帕金森病患者对正念冥想的期望、需求和举措。第二阶段为临床试验,目的是评估向帕金森病患者推荐的正念冥想(MBSR)计划的可行性、可接受性和效果:在第一阶段,向法国帕金森病患者协会(France Parkinson)成员和法国 MBSR 合格指导员发放了在线调查问卷。在第二阶段,30 名帕金森病患者参与了一项临床试验,其中包括一项标准的 MBSR 课程,以及课程前后一个月的两次额外评估访问。数据收集包括全面临床评估、抑郁和焦虑症状评估、睡眠评估、疼痛评估和生活质量评估,以及面对面访谈,以对项目的可接受性和生活体验进行定性评估。我们向三组共 10 名患者推荐了三个 MBSR 项目:其中两个项目因大流行而在线进行,一个项目推荐给无波动或轻微波动的患者(第 1 组),一个项目推荐给轻微至中度波动的患者(第 2 组),最后一个项目推荐给无波动或轻微波动的患者(第 3 组):法国调查:向法国帕金森协会会员发出的调查问卷共收到 209 份答复;向讲师发出的调查问卷共收到 68 份答复。三分之二的受访患者听说过正念冥想(66%),但并不知道这种方法的真正含义以及如何真正帮助他们。很少有指导者(29%)在其目前的实践中与帕金森病患者打过交道。然而,90% 的受访患者表示,他们赞成在护理中引入这种方法:临床试验:结果表明,无论是在线还是面对面,该计划对帕金森病患者来说都是可行和可接受的。在注册的 30 名患者中,有 25 人完成了该项目。没有观察到与正念冥想练习相关的不良反应。结果显示,焦虑症状、抑郁症状和生活质量的改善在统计学上有显著降低。此外,疼痛或睡眠质量方面的变化在统计学上并不明显。患者组之间的结果没有明显差异。在定性分析中,强调的主要主题与以下方面有关(i) 计划期间的生活体验;(ii) 日常生活的变化;(iii) 与疾病相关的变化。绝大多数完成计划的患者(24/25)认为他们的参与是积极或非常积极的。他们表示,在实施新的行为策略方面,尤其是在自我护理、接受和消除对疾病的认同方面,他们更好地管理了压力和情绪,也有了更大的自主权:结论:尽管人们对正念疗法抱有很高的期望,但帕金森氏症患者对现有的正念疗法项目知之甚少。然而,这项研究表明,无论是在线还是面对面提供的这些项目都特别有益,尤其是对焦虑和抑郁症状,至少在疾病的轻中度阶段是如此。
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引用次数: 0
Professor Alan B. Scott (1932–2021): “The inventor of Botox” 艾伦·b·斯科特教授(1932-2021):“肉毒杆菌的发明者”。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2023.10.012
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引用次数: 0
Dropped head syndrome in severe hypotension 严重低血压时的低头综合征。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.03.012

Introduction

Dropped head syndrome (DHS) is characterized by a chin-on-chest deformity, correctable by passive neck extension.

Methods

Case report.

Results

A patient with a heavy nephrological history (dialyzed since 5 years) complained for twenty months about a falling head. The symptomatology was punctuated by dialysis sessions, with aggravation secondary to dialysis. Clinical and paraclinical exploration for neurological, neuromuscular or orthopedic disease was negative. Analysis of the post-dialysis blood pressure showed a slow and gradual decline. From the date the patient became symptomatic, blood pressure was below 80/40 mmHg. The correction of blood pressure by increasing midodrine posology resulted in a cure of DHS.

Discussion

Considering the negativity of explorations, the cure of symptoms following the correction of arterial hypotension, the rhythmic nature of symptomatology by dialysis, and the recurrence of symptoms concomitantly with drops in blood pressure, we suggested that hypotension was the only etiology explaining this DHS.
简介低头综合征(DHS)的特征是下巴对着胸部的畸形,可通过颈部被动伸展进行矫正:方法:病例报告:一名有严重肾病史的患者(透析 5 年)20 个月来一直抱怨头部下垂。症状在透析过程中时有发生,透析后症状加重。临床和辅助检查均未发现神经、神经肌肉或骨科疾病。对透析后血压的分析表明,血压在缓慢逐渐下降。自患者出现症状之日起,血压一直低于 80/40mmHg。通过增加米多君的剂量来纠正血压,最终治愈了 DHS:考虑到探查的阴性、动脉低血压纠正后症状的治愈、透析后症状的节律性以及血压下降时症状的复发,我们认为低血压是解释该 DHS 的唯一病因。
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引用次数: 0
Model-based cueing-as-needed for walking in Parkinson's disease: A randomized cross-over study 基于模型的帕金森病患者行走提示:随机交叉研究
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.05.003

Background

Correcting of the lack of regularity in steps is a key component of gait rehabilitation in Parkinson's disease. We proposed to introduce adaptive spatial auditory cueing (ASAC) based on verbal instruction “lengthen the step” automatically delivered when the stride length decreased below a predetermined threshold.

Objectives

The present study compared the effect of usual rhythmic auditory cueing versus ASAC used during a walking training in Parkinson's disease.

Methods

Fifteen patients with Parkinson's disease performed both interventions in randomized order, one week apart: a 20-minute walking training with rhythmic auditory cueing, in form of a metronome adjusted on 110% of the patient's own cadence, or ASAC delivered when the stride length is less than 110% of the patient's own stride length. Assessment criteria were walking distance covered during the intervention, speed, step length, cadence, coefficients of variation of step length and step duration, and indexes of spatial and temporal asymmetry during a walking test before and just after the intervention.

Results

The walking distance is higher with ASAC compared with rhythmic auditory cueing (rhythmic auditory cueing, 905 (203) m, mean (standard deviation); ASAC, 1043 (212) m; P = 0.002). Between-intervention comparison showed some similar effects on walking after the intervention including free speed and step length increases (P < 0.05).

Conclusion

The distance covered during 20-minute walking with ASAC increases by 15% compared to the use of classical rhythmic auditory cueing, while the immediate therapeutic effects show similar spatial-temporal benefits on short-distance walking. Auditory biofeedback cueing promoting the increase in step length might improve gait relearning in Parkinson's disease.
背景:纠正步伐缺乏规律性是帕金森病步态康复的关键组成部分。我们建议引入自适应空间听觉提示(ASAC),当步长下降到预定阈值以下时,自动发出 "延长步长 "的口头指令:本研究比较了帕金森病患者在步行训练中使用普通节奏性听觉提示与 ASAC 的效果:15名帕金森病患者按照随机顺序进行了两种干预,时间间隔为一周:20分钟的步行训练,采用节拍器的形式进行有节奏的听觉提示,节拍器调整为患者自身步速的110%,或在步长小于患者自身步长的110%时进行ASAC。评估标准包括干预期间的步行距离、速度、步长、步频、步长和步长变异系数,以及干预前后步行测试中的空间和时间不对称指数:结果:与有节奏的听觉提示相比,有节奏的听觉提示的步行距离更长(有节奏的听觉提示,905(203)米,平均值(标准差);有节奏的听觉提示,1043(212)米;P=0.002)。干预之间的比较显示,干预后的步行效果相似,包括自由速度和步长的增加(PC 结论:在 20 分钟的步行过程中,听觉提示的步行距离增加了 10%:与使用经典节奏性听觉提示相比,使用 ASAC 进行 20 分钟步行的距离增加了 15%,而即时治疗效果则显示出对短距离步行具有类似的时空益处。促进步长增加的听觉生物反馈提示可改善帕金森病患者的步态再学习能力。
{"title":"Model-based cueing-as-needed for walking in Parkinson's disease: A randomized cross-over study","authors":"","doi":"10.1016/j.neurol.2024.05.003","DOIUrl":"10.1016/j.neurol.2024.05.003","url":null,"abstract":"<div><h3>Background</h3><div>Correcting of the lack of regularity in steps is a key component of gait rehabilitation in Parkinson's disease<span>. We proposed to introduce adaptive spatial auditory cueing (ASAC) based on verbal instruction “lengthen the step” automatically delivered when the stride length decreased below a predetermined threshold.</span></div></div><div><h3>Objectives</h3><div>The present study compared the effect of usual rhythmic auditory cueing versus ASAC used during a walking training in Parkinson's disease.</div></div><div><h3>Methods</h3><div><span><span>Fifteen patients with Parkinson's disease performed both interventions in randomized order, one week apart: a 20-minute walking training with rhythmic auditory cueing, in form of a metronome adjusted on 110% of the patient's own cadence, or ASAC delivered when the stride length is less than 110% of the patient's own stride length. Assessment criteria were walking distance covered during the intervention, speed, </span>step length, cadence, coefficients of variation of step length and step duration, and indexes of spatial and temporal asymmetry during a </span>walking test before and just after the intervention.</div></div><div><h3>Results</h3><div>The walking distance is higher with ASAC compared with rhythmic auditory cueing (rhythmic auditory cueing, 905 (203) m, mean (standard deviation); ASAC, 1043 (212) m; <em>P</em> <!-->=<!--> <!-->0.002). Between-intervention comparison showed some similar effects on walking after the intervention including free speed and step length increases (<em>P</em> <!-->&lt;<!--> <!-->0.05).</div></div><div><h3>Conclusion</h3><div>The distance covered during 20-minute walking with ASAC increases by 15% compared to the use of classical rhythmic auditory cueing, while the immediate therapeutic effects show similar spatial-temporal benefits on short-distance walking. Auditory biofeedback cueing promoting the increase in step length might improve gait relearning in Parkinson's disease.</div></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":2.8,"publicationDate":"2024-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141248250","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Impact of multiple sclerosis on employment and income: Insights from a random sample representative of private sector employees in France using longitudinal administrative data 多发性硬化症对就业和收入的影响:利用纵向行政数据从法国私营部门雇员随机抽样中获得的启示。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.02.389
In France, few data sources are available to estimate the impact of multiple sclerosis (MS) on job retention and its consequences on the level of resources, especially in large representative samples. The aim of the present study was to measure impact of MS on employment rates, wages and income (including unemployment benefit, sickness benefit and disability pension) by comparing work trajectories of people living with MS with those of a matched control group. We used the HYGIE database, which is the result of the linkage of two administrative databases in the private sector for a random sample of over 900,000 people. In order to identify the causal effect of MS on employment after 1 to 20 years, the difference-in-differences method with matching (age, sex, career and health history) was used, overall and in subgroups. The year of entry in long-term disease status for MS was used to approximate the onset of MS. Overall, 946 people with MS were included. Their situation was fairly favorable before MS (88.1% in employment, resources higher than the median for the general population), but MS had strong and continuous negative effects. Indeed, at 10 years, the employment rate fell by 28.6 percentage points (pp) and the disability pension allowance increased by 50.5 pp; the wage percentile fell by 19.2 pp and the replacement income accounted for a growing share of total income (+ 39.7 pp). Although administrative data had several strengths, clinical information on the severity of the disease or on its therapeutic management was not available. In conclusion, this study shows that the effects of MS on the employed population in the private sector occur early in the disease course and are cumulative, and that replacement income helps to reduce the loss of resources thanks to the French health and social system.
在法国,很少有数据来源可用于估算多发性硬化症(MS)对保留工作的影响及其对资源水平的影响,尤其是在大型代表性样本中。本研究旨在通过比较多发性硬化症患者与匹配对照组的工作轨迹,衡量多发性硬化症对就业率、工资和收入(包括失业救济金、疾病救济金和残疾抚恤金)的影响。我们使用了 HYGIE 数据库,该数据库是将私营部门的两个行政数据库连接起来的结果,随机抽取了 90 多万人。为了确定多发性硬化症对 1 至 20 年后就业的因果影响,我们采用了差异匹配法(年龄、性别、职业和健康史),包括总体和分组。多发性硬化症患者进入长期疾病状态的年份被用来近似多发性硬化症的发病年份。总共纳入了 946 名多发性硬化症患者。他们在患多发性硬化症之前的情况相当良好(88.1%的人就业,资源高于普通人群的中位数),但多发性硬化症对他们产生了强烈且持续的负面影响。事实上,在 10 年的时间里,就业率下降了 28.6 个百分点(pp),残疾抚恤金津贴增加了 50.5 个百分点;工资百分位数下降了 19.2 个百分点,替代收入在总收入中所占的比例越来越大(+ 39.7 个百分点)。虽然行政数据有一些优势,但没有关于疾病严重程度或治疗管理的临床信息。总之,这项研究表明,多发性硬化症对私营部门就业人口的影响发生在病程早期,并且是累积性的,而替代收入有助于减少资源损失,这要归功于法国的医疗和社会体系。
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引用次数: 0
French guidelines for the diagnosis and management of Tourette syndrome 法国图雷特综合征诊断和管理指南。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.04.005
<div><div>The term “Gilles de la Tourette syndrome”, or the more commonly used term “Tourette syndrome” (TS) refers to the association of motor and phonic tics which evolve in a context of variable but frequent psychiatric comorbidity. The syndrome is characterized by the association of several motor tics and at least one phonic tic that have no identifiable cause, are present for at least one year and appear before the age of 18. The presence of coprolalia is not necessary to establish or rule out the diagnosis, as it is present in only 10% of cases. The diagnosis of TS is purely clinical and is based on the symptoms defined by the Diagnostic and Statistical Manual of Mental Disorders (DSM-5). No additional tests are required to confirm the diagnosis of TS. However, to exclude certain differential diagnoses, further tests may be necessary. Very frequently, one or more psychiatric comorbidities are also present, including attention deficit hyperactivity disorder, obsessive-compulsive disorder, anxiety, explosive outbursts, self-injurious behaviors, learning disorders or autism spectrum disorder. The condition begins in childhood around 6 or 7 years of age and progresses gradually, with periods of relative waxing and waning of tics. The majority of patients experience improvement by the end of the second decade of life, but symptoms may persist into adulthood in around one-third of patients. The cause of TS is unknown, but genetic susceptibility and certain environmental factors appear to play a role. The treatment of TS and severe forms of tics is often challenging and requires a multidisciplinary approach (involving the general practitioner (GP), pediatrician, psychiatrist, neurologist, school or occupational physicians, psychologist and social workers). In mild forms, education (of young patients, parents and siblings) and psychological management are usually recommended. Medical treatments, including antipsychotics, are essential in the moderate to severe forms of the disease (i.e. when there is a functional and/or psychosocial discomfort linked to tics). Over the past decade, cognitive-behavioral therapies have been validated for the treatment of tics. For certain isolated tics, botulinum toxin injections may also be useful. Psychiatric comorbidities, when present, often require a specific treatment. For very severe forms of TS, treatment by deep brain stimulation offers real therapeutic hope. If tics are suspected and social or functional impairment is significant, specialist advice should be sought, in accordance with the patient's age (psychiatrist/child psychiatrist; neurologist/pediatric neurologist). They will determine tic severity and the presence or absence of comorbidities. The GP will take over the management and prescription of treatment: encouraging treatment compliance, assessing side effects, and combating stigmatization among family and friends. They will also play an important role in rehabilitation therapies, as well as in e
吉勒-德拉-图雷特综合征 "或更常用的术语 "图雷特综合征"(TS)是指运动性抽动和发音性抽动的综合征,这些抽动是在精神疾病并发症多变但频繁的情况下发生的。该综合征的特征是,患者伴有几种运动性抽动和至少一种发音性抽动,这些抽动无法确定原因,至少持续一年,并且在 18 岁之前出现。秽语抽动并不是确诊或排除诊断的必要条件,因为只有 10% 的病例会出现秽语抽动。TS 的诊断纯属临床诊断,以《精神疾病诊断与统计手册》(DSM-5)中定义的症状为依据。确诊 TS 无需进行其他检查。不过,为了排除某些鉴别诊断,可能需要进行进一步检查。很多情况下,TS 还伴有一种或多种精神并发症,包括注意力缺陷多动障碍、强迫症、焦虑症、爆发力、自伤行为、学习障碍或自闭症谱系障碍。这种病在儿童期约 6 或 7 岁时开始出现,病情逐渐发展,抽搐症状会有相对的消长期。大多数患者在第二个十年结束时症状会有所改善,但约有三分之一的患者症状会持续到成年。TS 的病因尚不清楚,但遗传易感性和某些环境因素似乎在其中发挥了作用。TS 和严重抽搐症的治疗通常具有挑战性,需要采用多学科方法(包括全科医生、儿科医生、精神科医生、神经科医生、学校或职业医生、心理学家和社会工作者)。对于轻度抽搐,通常建议对年轻患者、父母和兄弟姐妹进行教育和心理治疗。对于中度至重度患者(即因抽搐导致功能和/或心理不适),包括抗精神病药物在内的药物治疗是必不可少的。在过去十年中,认知行为疗法已被证实可用于治疗抽搐。对于某些孤立的抽搐,注射肉毒杆菌毒素也可能有用。如果存在精神并发症,通常需要进行特殊治疗。对于非常严重的 TS,脑深部刺激疗法带来了真正的治疗希望。如果怀疑患有抽搐症,且社交或功能障碍严重,则应根据患者的年龄寻求专科医生的建议(精神科医生/儿童精神科医生;神经科医生/儿童神经科医生)。他们将确定抽搐的严重程度以及是否存在合并症。全科医生将负责管理和开具治疗处方:鼓励患者遵从治疗、评估副作用、消除家人和朋友对患者的鄙视。他们还将在康复治疗中发挥重要作用,并确保在患者的学校或职业环境中为其提供便利。
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引用次数: 0
Marian apparitions: A multidisciplinary approach. The case of Île Bouchard 玛利亚显灵:多学科方法。布沙尔岛案例。
IF 2.8 4区 医学 Q2 CLINICAL NEUROLOGY Pub Date : 2024-10-01 DOI: 10.1016/j.neurol.2024.04.008
Discussing Marian apparitions in the light of current knowledge in neuroscience is a challenge: the testimonies are often old and indirect, and the “visionaries” could not be questioned or even examined according to current neurological or psychiatric standards. In doing so, we are not unaware of the heterogeneity of seers and the facts they reported: there is not necessarily a single hypothesis. It is the appearances of Île Bouchard that will be discussed here. Our interpretation calls on two non-exclusive “mechanisms”: on the one hand, mental imagery, which we know can be unconscious and is modulated or generated by frontal “top-down” mechanisms; on the other hand, the sociological consideration of events, using the concept of enchantment.
根据当前的神经科学知识来讨论圣母显灵是一项挑战:这些证词往往是陈旧而间接的,"显灵者 "无法受到质疑,甚至无法根据当前的神经学或精神病学标准进行检查。在此过程中,我们并非没有意识到先知及其所报告事实的异质性:不一定存在单一的假说。这里要讨论的是布沙尔岛的表象。我们的解释需要两种非排他性的 "机制":一方面是心理意象,我们知道这种意象可能是无意识的,并由前额 "自上而下 "的机制调节或产生;另一方面是对事件的社会学思考,使用 "着魔 "的概念。
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引用次数: 0
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Revue neurologique
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