Revue neurologique最新文献_第7页

Fatal natalizumab-associated progressive multifocal leukoencephalopathy with initial low JCV antibody index in a multiple sclerosis patient 一名多发性硬化症患者在最初JCV抗体指数较低的情况下出现纳他珠单抗相关的进行性多灶性白质脑病，并致人死亡。

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-06-01 DOI: 10.1016/j.neurol.2023.11.011

M. Hay , S. Leguy , V. Cahagne , N. Lassalle , E. Le Page , L. Michel

引用次数: 0

Between neurology and psychiatry: The lively history of right hemisphere syndromes 神经病学和精神病学之间：右半球综合征的生动历史。

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-06-01 DOI: 10.1016/j.neurol.2023.07.013

K.G. Langer , J. Bogousslavsky

引用次数: 0

Outcome of stroke patients eligible to mechanical thrombectomy managed by spoke center, primary stroke center or comprehensive stroke center in the East of France 在法国东部，卒中中心、初级卒中中心或综合卒中中心接受机械取栓治疗的卒中患者的结果。

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-06-01 DOI: 10.1016/j.neurol.2023.08.020

W. Abou Loukoul , S. Richard , G. Mione , S. Finitsis , A.-L. Derelle , F. Zhu , L. Liao , R. Anxionnat , M. Douarinou , L. Humbertjean , B. Gory

Background and purpose

Patients with suspected stroke are referred to the nearest hospital and are managed either in a spoke center (SC), a primary stroke center (PSC), or a comprehensive stroke center (CSC) in order to benefit from early intravenous thrombolysis (IVT). In case of large vessel occlusion (LVO), mechanical thrombectomy (MT) is only performed in the CSC, whereas the effectiveness of MT is highly time-dependent. There is a debate about the best management model of patients with suspected LVO. Therefore, we aimed to compare functional and safety outcomes of LVO patients eligible for MT managed through our regional telestroke system.

Method

We performed a retrospective analysis of our observational prospective clinical registry in all consecutive subjects with LVO within six hours of onset who were admitted to the SC, PSC, or CSC in the east of France between October 2017 and November 2022. The primary endpoint was the functional independence defined as modified Rankin scale (mRS) score 0 to 2 at 90 days. Secondary endpoints were functional outcome, early neurological improvement, symptomatic intracranial hemorrhage and 90-day mortality.

Results

Among the 794 included patients with LVO who underwent MT, 122 (15.4%) were managed by a SC, 403 (50.8%) were first admitted to a PSC, and 269 (33.9%) were first admitted to the CSC. The overall median NIHSS and ASPECTS score were 16 and 8, respectively. Multivariate analysis did not find any significant difference for the primary endpoint between patients managed by PSC versus CSC (OR 1.06 [95% CI 0.64;1.76], P = 0.82) and between patient managed by SC versus CSC (OR 0.69 [0.34;1.40], P = 0.30). No difference between the three groups was found except for the parenchymal hematoma rate between PSC and CSC (15.7 versus 7.4%, OR 2.25 [1.07;4.74], P = 0.032).

Conclusions

Compared with a first admission to a CSC, the clinical outcomes of stroke patients with LVO eligible for MT first admitted to a SC or a PSC are similar.

背景和目的:疑似中风的患者被转诊到最近的医院，并在spoke中心(SC)、primary卒中中心(PSC)或comprehensive卒中中心(CSC)进行治疗，以便从早期静脉溶栓(IVT)中获益。在大血管闭塞(LVO)的情况下，机械取栓(MT)仅在CSC中进行，而MT的有效性高度依赖于时间。对于疑似LVO患者的最佳管理模式存在争议。因此，我们的目的是比较通过我们的区域性远程卒中系统进行MT管理的LVO患者的功能和安全性结果。方法:我们对2017年10月至2022年11月在法国东部的SC、PSC或CSC住院的所有连续6小时内LVO患者的观察性前瞻性临床登记进行了回顾性分析。主要终点是功能独立性，定义为90天时修改的Rankin量表(mRS)评分0到2分。次要终点是功能结局、早期神经系统改善、症状性颅内出血和90天死亡率。结果:在794例接受MT治疗的LVO患者中，122例(15.4%)接受SC治疗，403例(50.8%)首次入住PSC, 269例(33.9%)首次入住CSC。NIHSS和ASPECTS的总中位数分别为16分和8分。多因素分析未发现PSC与CSC患者的主要终点有显著差异(OR 1.06 [95% CI 0.64;1.76]， P=0.82)， SC与CSC患者的主要终点有显著差异(OR 0.69 [0.34;1.40]， P=0.30)。除了PSC和CSC的实质血肿率(15.7 vs 7.4%， OR 2.25 [1.07;4.74]， P=0.032)外，三组间无差异。结论:与首次入住CSC相比，首次入住SC或PSC的符合MT条件的LVO卒中患者的临床结果相似。

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引用次数: 0

Does the guidance method affect the doses of botulinum toxin in writer's cramp? 指导方法是否会影响肉毒杆菌毒素治疗作家痉挛的剂量？

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-06-01 DOI: 10.1016/j.neurol.2023.11.009

A. Kreisler , K. Watel , L. Defebvre , L. Mortain , A. Duhamel

Purpose

Botulinum neurotoxin (BoNT) injections are the main medical treatment of writer's cramp. When the outcome is favourable, patients usually receive injections several times per year in the long-term. However, we know little about the course of BoNT doses and nothing about the impact of the guidance method on the clinical outcome or injection strategy.

Methods

We studied, in the long-term, the doses of BoNT and the target muscles in a group of patients with writer's cramp, according to the guidance method (electrical stimulation or ultrasound). Patients received at least three injection cycles guided by electrical stimulation, followed by at least three injection cycles guided by ultrasound.

Results

Twenty-four patients were included. More target muscles were injected after switching to ultrasound guidance, especially the flexor carpi ulnaris and the flexor carpi radialis. The mean dose by muscle was lower when ultrasound guidance was used. When using electrical stimulation guidance, the dose in the flexors of the fingers decreased in the long-term, but increased in the flexors of the wrist. The course of the BoNT doses and of the number of target muscles per cycle were not the same during the first period (electrical stimulation) and the second period (ultrasound).

Conclusions

Switching to ultrasound guidance, the BoNT dose decreased, mainly in the flexors of the wrist. Based on the results of our study, we suggest a starting dose in several muscles (flexor carpi ulnaris, flexor carpi radialis, flexor digitorum profundus and flexor pollicis longus).

目的：注射肉毒杆菌神经毒素（BoNT）是治疗作家痉挛的主要药物。如果疗效良好，患者通常会长期接受每年数次的注射。然而，我们对 BoNT 剂量的疗程知之甚少，也不了解引导方法对临床效果或注射策略的影响：我们根据引导方法（电刺激或超声波）对一组作家痉挛患者的 BoNT 剂量和目标肌肉进行了长期研究。患者在电刺激引导下接受至少三个注射周期，然后在超声引导下接受至少三个注射周期：结果：共纳入 24 名患者。改用超声引导后，注射的目标肌肉更多，尤其是尺侧屈肌和桡侧屈肌。使用超声引导时，肌肉的平均剂量较低。使用电刺激引导时，手指屈肌的剂量长期减少，但手腕屈肌的剂量增加。在第一阶段（电刺激）和第二阶段（超声波）中，BoNT剂量和每个周期目标肌肉数量的变化过程并不相同：结论：改用超声引导后，BoNT剂量减少，主要是腕部屈肌。根据我们的研究结果，我们建议在几块肌肉（尺侧屈肌、桡侧屈肌、趾侧屈肌和拇侧屈肌）中使用起始剂量。

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引用次数: 0

Evaluation of quality of life's prognostic factors in people with functional seizures 功能性癫痫发作患者生活质量预后因素的评价。

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-06-01 DOI: 10.1016/j.neurol.2023.09.007

P. Capitaine , B. Thomas , A. Gradel , T. Ferté , O. Branchard , E. Frison , V. Renaudeau , J. Aupy

Aims

Functional non-epileptic seizures significantly impact the quality of life of patients. We aimed to identify prognostic factors associated with the quality of life in individuals with functional non-epileptic seizures.

Subjects and methods

Adult patients diagnosed with definite or documented functional seizures based on LaFrance's criteria (n = 72) were enrolled at the time of diagnosis. Quality of life was assessed using the Quality of Life in Epilepsy Inventory-31 (QOLIE-31) at diagnosis and at a six-month follow-up. Demographic and medical information was collected, and psychiatric comorbidities were evaluated using validated scales.

Results

Comparisons between diagnosis and follow-up did not reveal any factors associated with improvement in quality of life at six months after diagnosis. However, multivariable analysis, adjusted for age, sex, diagnosis delay, and frequency of functional seizures showed a significant cross-sectional relationship with a QOLIE-31 score decrease of 0.66 [95% CI −0.93;−0.39], −0.32 [−0.61; −0.03], and −0.22 [−0.42; −0.02] for an increase of 1 point of BDI-2 score, BAI score, and CTQ score respectively.

Conclusion

Psychiatric comorbidities, particularly depression and anxiety, are associated with worse quality of life in patients with functional seizures. This underscores the crucial importance of multidisciplinary care involving both neurological and psychiatric expertise when managing individuals with functional seizures.

目的:功能性非癫痫性发作显著影响患者的生活质量。我们的目的是确定与功能性非癫痫性发作患者生活质量相关的预后因素。对象和方法:根据LaFrance标准诊断为明确或记录的功能性癫痫发作的成年患者(n=72)在诊断时入选。在诊断时和6个月随访时，使用癫痫生活质量量表-31 (QOLIE-31)评估患者的生活质量。收集人口统计和医学信息，并使用有效的量表评估精神疾病。结果:诊断和随访的比较没有发现任何与诊断后6个月生活质量改善相关的因素。然而，经年龄、性别、诊断延迟和功能性癫痫发作频率调整后的多变量分析显示，与QOLIE-31评分下降有显著的横断面关系:0.66 [95% CI -0.93;-0.39]， -0.32 [-0.61;-0.03]， -0.22 [-0.42;-0.02]， BDI-2评分、BAI评分、CTQ评分分别提高1分。结论:精神合并症，特别是抑郁和焦虑，与功能性癫痫发作患者的生活质量下降有关。这强调了在管理功能性癫痫患者时，涉及神经学和精神病学专业知识的多学科护理的至关重要性。

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引用次数: 0

SWI versus GRE-T2*: Assessing cortical superficial siderosis in advanced cerebral amyloid angiopathy SWI 与 GRE-T2*：评估晚期脑淀粉样变性血管病的皮质表层巩膜病变

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-06-01 DOI: 10.1016/j.neurol.2023.10.008

P. Assis Lopes , N. Raposo , A. Charidimou , M.C. Zanon Zotin , M. Edip Gurol , S. Greenberg , A. Viswanathan

Background and purpose

Cortical superficial siderosis (cSS) is a key neuroimaging marker of cerebral amyloid angiopathy (CAA) detected on blood-sensitive magnetic resonance imaging (MRI). We aimed to assess cSS in advanced CAA patients and explore differences in its evaluation between susceptibility weighted imaging (SWI) and gradient recalled echo-T2* (GRE-T2*).

Materials and methods

Neuroimaging data gathered from a prospective cohort of CAA patients with probable or definite CAA were retrospectively analyzed by two independent raters. SWI and GRE-T2* were used to assess presence and severity (absent, focal [≤ 3 sulci] or disseminated [> 3 sulci]) of cSS and number of foci. Ratings were compared between sequences and inter-rater agreement was determined. Post hoc analysis explored differences in cSS multifocality scores.

Results

We detected cSS in 38 patients with SWI and in 36 with GRE-T2* (70.4% versus 66.7%; P = 0.5). The two raters agreed in detecting more disseminated cSS when using SWI: 16 focal (29.63%) and 20 disseminated (37.04%) cases of cSS seen on GRE-T2* and 11 (20.37%) focal and 27 (50%) disseminated cSS cases seen using SWI (P = 0.008). Inter-rater agreement was equivalent for the two sequences (κ_presence 0.7 versus 0.69; κ_severity 0.74 versus 0.66) for assessing both presence and severity of cSS. Post hoc analysis showed higher multifocality scores from both raters’ SWI evaluations, with agreement equivalent to that for T2* evaluations.

Conclusions

Our findings suggest that SWI ratings could show more disseminated cSS and higher multifocality scores in advanced CAA patients with inter-rater reliability equivalent to that obtained using GRE-T2*, regardless of level of experience.

背景和目的皮质浅层鳞状上皮细胞增多症（cSS）是血敏磁共振成像（MRI）检测到的脑淀粉样血管病（CAA）的一个关键神经影像学标志物。我们的目的是评估晚期 CAA 患者的 cSS，并探索感性加权成像（SWI）和梯度回波-T2*（GRE-T2*）在评估 cSS 方面的差异。SWI和GRE-T2*用于评估cSS的存在和严重程度（无、局灶性[≤3个沟]或播散性[> 3个沟]）以及病灶的数量。对不同序列的评分进行比较，并确定评分者之间的一致性。结果我们在 38 例 SWI 患者和 36 例 GRE-T2* 患者中发现了 cSS（70.4% 对 66.7%；P = 0.5）。在使用 SWI 时，两位评分员一致认为能检测出更多的播散性 cSS：GRE-T2* 检测出 16 例局灶性 cSS（29.63%）和 20 例播散性 cSS（37.04%），SWI 检测出 11 例局灶性 cSS（20.37%）和 27 例播散性 cSS（50%）（P = 0.008）。在评估 cSS 的存在和严重程度方面，两种序列的评分者之间的一致性相当（κ存在 0.7 对 0.69；κ严重 0.74 对 0.66）。结论我们的研究结果表明，SWI 评级可显示晚期 CAA 患者中更多的扩散性 cSS 和更高的多灶性评分，评分者之间的可靠性与使用 GRE-T2* 获得的结果相当，与经验水平无关。

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引用次数: 0

“Status trigeminal neuralgia”: Analysis of 39 cases and proposal for diagnostic criteria "状态性三叉神经痛"：39 例病例分析及诊断标准建议。

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique

Pub Date : 2024-05-23 DOI: 10.1016/j.neurol.2024.03.014

Objective

The aim of this descriptive study was to propose diagnostic criteria for acute exacerbation of trigeminal neuralgia (TN) based on the analysis of retrospective cases.

Background

TN is a rare and extremely painful condition whose evolution can be punctuated by major exacerbations, leading to significant functional impairment. Several denominations are used for these exacerbations: “acute exacerbation”, “status of trigeminal neuralgia”, and “status trigeminus”. There is currently no clinical definition of this state. In this manuscript, we used the term “status trigeminal neuralgia” (STN).

Methods

We conducted a retrospective study, in a tertiary care specialist headache center, in France. Patients were selected from January 2015 to October 2022, with the French translation of the keyword “STN”, in the medical records (outpatients) or the codage for trigeminal neuralgia (inpatients). Additional cases of STN were prospectively recruited from October 2022 to February 2023. We analyzed the clinical and paraclinical data of these patients.

Results

Thirty-nine patients presenting with STN were included. There was a preponderance of women (64%) with 24 cases of classic TN (62%) and 15 cases of secondary TN (38%). Concerning STN, 39 episodes were described. Pain was very severe in all patients. Cranial autonomic signs were present in 23% of cases. Pain extended beyond the usual territory in 44% of cases. A continuous pain background was present in 35% of cases. With regard to triggering factors, paroxysms of facial pain were triggered by eating (97% of patients), speaking (90%) or drinking (62% of patients). Repercussions on weight, hydration, or mood disorders were observed in 67%, 56% and 59% of the cases, respectively.

Conclusion

STN is a rare clinical presentation of TN. We proposed criteria and a new denomination for this condition.

目的：本描述性研究旨在根据对回顾性病例的分析，提出三叉神经痛（TN）急性加重的诊断标准：这项描述性研究旨在根据对回顾性病例的分析，提出三叉神经痛（TN）急性加重的诊断标准：背景：三叉神经痛是一种罕见且极其痛苦的疾病，其发展过程中可能会出现严重的病情加重，从而导致严重的功能障碍。这些恶化有几种名称："急性加重"、"三叉神经痛状态 "和 "三叉神经痛状态"。目前还没有关于这种状态的临床定义。在本手稿中，我们使用了 "三叉神经痛状态"（STN）一词：我们在法国一家三级头痛专科医疗中心进行了一项回顾性研究。研究选取了2015年1月至2022年10月期间的患者，这些患者的病历（门诊患者）或三叉神经痛代码（住院患者）中均有 "STN "这一关键词的法文译文。2022 年 10 月至 2023 年 2 月期间，我们又对其他 STN 病例进行了前瞻性招募。我们分析了这些患者的临床和辅助临床数据：结果：共纳入 39 例 STN 患者。其中女性占多数（64%），24 例为典型 TN（62%），15 例为继发性 TN（38%）。关于 STN，共描述了 39 次发作。所有患者的疼痛都非常剧烈。23%的病例出现颅内自主神经体征。44%的病例的疼痛范围超出了正常范围。35%的病例存在持续的疼痛背景。在诱发因素方面，进食（97% 的患者）、说话（90% 的患者）或饮酒（62% 的患者）会诱发阵发性面部疼痛。67%、56%和59%的病例观察到了对体重、水分或情绪障碍的影响：结论：STN 是 TN 的一种罕见临床表现。结论：STN 是 TN 的一种罕见临床表现，我们为这种病症提出了标准和新的命名。

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引用次数: 0

Could PLS represent a UMN-predominant ALS syndrome? PLS 是否代表一种 UMN 显性 ALS 综合征？

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-05-22 DOI: 10.1016/j.neurol.2024.04.006

P Corcia, P Couratier, C Ingre

Primary lateral sclerosis (PLS) is a motor neuron condition marked by pure upper motor neuron (UMN) degeneration. PLS represents around 3% of all motor neuron diseases. Classically the prognosis of PLS is less severe than those of amyotrophic lateral sclerosis (ALS). This explains the necessity to distinguish both conditions as early as possible. The key hallmark between the two diseases is the involvement of the lower motor neuron (LMN) system which is classically considered spared in PLS contrary to ALS. Although it seemed clinically easy to distinguish PLS from ALS with the aid of clinical and complementary examinations, there is a large body of evidence highlighting that the LMN system might be impaired in PLS. This led us to suggest that PLS might be considered as an almost pure UMN ALS phenotype.

原发性侧索硬化症（PLS）是一种以单纯上运动神经元（UMN）变性为特征的运动神经元疾病。原发性侧索硬化症约占所有运动神经元疾病的 3%。与肌萎缩侧索硬化症（ALS）相比，原发性肌萎缩侧索硬化症的预后通常较轻。因此，有必要尽早区分这两种疾病。这两种疾病的主要特征是下运动神经元（LMN）系统受累，与 ALS 相反，下运动神经元系统在 PLS 中通常被认为是不受影响的。虽然在临床上，借助临床和辅助检查似乎很容易将 PLS 与 ALS 区分开来，但有大量证据表明，LMN 系统可能在 PLS 中受损。这使我们认为，PLS 可被视为一种几乎纯粹的 UMN ALS 表型。

引用次数: 0

Clinical applications of deep learning in neuroinflammatory diseases: A scoping review. 深度学习在神经炎性疾病中的临床应用：范围综述。

IF 3 4区医学 Q2 Medicine

Revue neurologique

Pub Date : 2024-05-20 DOI: 10.1016/j.neurol.2024.04.004

S Demuth, J Paris, I Faddeenkov, J De Sèze, P-A Gourraud

Background: Deep learning (DL) is an artificial intelligence technology that has aroused much excitement for predictive medicine due to its ability to process raw data modalities such as images, text, and time series of signals.

Objectives: Here, we intend to give the clinical reader elements to understand this technology, taking neuroinflammatory diseases as an illustrative use case of clinical translation efforts. We reviewed the scope of this rapidly evolving field to get quantitative insights about which clinical applications concentrate the efforts and which data modalities are most commonly used.

Methods: We queried the PubMed database for articles reporting DL algorithms for clinical applications in neuroinflammatory diseases and the radiology.healthairegister.com website for commercial algorithms.

Results: The review included 148 articles published between 2018 and 2024 and five commercial algorithms. The clinical applications could be grouped as computer-aided diagnosis, individual prognosis, functional assessment, the segmentation of radiological structures, and the optimization of data acquisition. Our review highlighted important discrepancies in efforts. The segmentation of radiological structures and computer-aided diagnosis currently concentrate most efforts with an overrepresentation of imaging. Various model architectures have addressed different applications, relatively low volume of data, and diverse data modalities. We report the high-level technical characteristics of the algorithms and synthesize narratively the clinical applications. Predictive performances and some common a priori on this topic are finally discussed.

Conclusion: The currently reported efforts position DL as an information processing technology, enhancing existing modalities of paraclinical investigations and bringing perspectives to make innovative ones actionable for healthcare.

背景：深度学习（DL）是一种人工智能技术：深度学习（DL）是一种人工智能技术，由于它能够处理原始数据模式，如图像、文本和时间序列信号，因此在预测医学领域引起了广泛关注：在此，我们将以神经炎症性疾病作为临床转化工作的一个示例，为临床读者提供了解这项技术的要素。我们回顾了这一快速发展领域的范围，以获得关于哪些临床应用集中了这些努力以及哪些数据模式最常用的定量见解：我们在 PubMed 数据库中查询了报道神经炎症性疾病临床应用 DL 算法的文章，并在 radiology.healthairegister.com 网站上查询了商业算法：综述包括 2018 年至 2024 年间发表的 148 篇文章和 5 种商业算法。临床应用可分为计算机辅助诊断、个体预后、功能评估、放射结构分割和数据采集优化。我们的审查突出了工作中的重要差异。放射结构分割和计算机辅助诊断目前集中了大部分力量，而成像技术则占了很大比例。针对不同的应用、相对较低的数据量和不同的数据模式，有各种模型架构。我们报告了算法的高级技术特点，并对临床应用进行了综合叙述。最后还讨论了预测性能和有关这一主题的一些常见先验理论：目前所报告的工作将 DL 定位为一种信息处理技术，它增强了现有的准临床调查模式，并为创新的医疗保健可操作性带来了新的视角。

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引用次数: 0

Metabolic syndrome and the phenotype of multiple sclerosis 代谢综合征与多发性硬化症的表型。

IF 2.8 4区医学 Q2 CLINICAL NEUROLOGY

Revue neurologique

Pub Date : 2024-05-09 DOI: 10.1016/j.neurol.2024.03.009

Background

Comorbidities, particularly vascular comorbidities, have been shown to exacerbate the progression of disability in multiple sclerosis (MS). Metabolic syndrome (MetS) is a cluster of conditions including abdominal obesity, insulin resistance, atherogenic dyslipidemia, and vascular dysfunction, which contribute to vascular morbidity and chronic inflammation.

Objective

To describe the characteristics of MetS in a cohort of MS patients and evaluate its relationship with the MS phenotype.

Methods

A monocentric cohort study was conducted on MS patients, collecting demographic, clinical, radiological, and therapeutic data, as well as metabolic data including waist circumference, blood pressure, serum triglycerides, high-density lipoprotein cholesterol, and fasting blood glucose.

Results

Among the 84 patients included in the study, 27% were diagnosed with MetS. MetS was found to be associated with secondary progressive MS (SPMS). Patients with SPMS had a higher prevalence of MetS compared to those with relapsing-remitting MS (RRMS), even after adjusting for disease duration. While MetS was associated with Expanded Disability Status Scale (EDSS) progression in the 3-year period according to univariate analysis, it did not show a significant association with disease activity.

Conclusion

This study provides evidence supporting the connection between MetS and the progression of disability in MS, independent of disease relapse activity.

背景：合并症，尤其是血管合并症，已被证明会加剧多发性硬化症（MS）的残疾进展。代谢综合征（MetS）是包括腹型肥胖、胰岛素抵抗、致动脉粥样硬化性血脂异常和血管功能障碍在内的一组疾病，可导致血管疾病和慢性炎症：描述一组多发性硬化症患者的 MetS 特征，并评估其与多发性硬化症表型的关系：对多发性硬化症患者进行了一项单中心队列研究，收集了人口统计学、临床、放射学和治疗数据，以及包括腰围、血压、血清甘油三酯、高密度脂蛋白胆固醇和空腹血糖在内的代谢数据：在纳入研究的 84 名患者中，27% 被诊断为 MetS。研究发现，代谢综合征与继发性进行性多发性硬化症（SPMS）有关。与复发缓解型多发性硬化症（RRMS）患者相比，继发性进展型多发性硬化症患者的 MetS 患病率更高，即使在对病程进行调整后也是如此。根据单变量分析，MetS与3年内扩展残疾状态量表（EDSS）的进展有关，但与疾病活动性并无显著关联：本研究提供的证据支持了MetS与多发性硬化症残疾进展之间的联系，而与疾病复发活动无关。

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引用次数: 0