Pub Date : 2024-06-11DOI: 10.1016/j.neurol.2024.02.394
D Andriuta, M Roussel, G Chene, C Fischer, J-F Mangin, B Dubois, B Vellas, F Pasquier, F Tison, F Blanc, O Hanon, C Paquet, A Gabelle, M Ceccaldi, C Annweiler, P Krolak-Salmon, R David, I Rouch-Leroyer, A Benetos, O Moreaud, F Sellal, I Jalenques, P Vandel, V Bouteloup, O Godefroy
Background: The association between the pattern of cortical thickness (CT) and executive dysfunction (ED) in mild cognitive impairment (MCI) and subjective cognitive complaints (SCC) is still poorly understood. We aimed to investigate the association between CT and ED in a large French cohort (MEMENTO) of 2323 participants with MCI or SCC.
Methods: All participants with available CT and executive function data (verbal fluency and Trail Making Test [TMT]) were selected (n=1924). Linear regressions were performed to determine relationships between executive performance and the brain parenchymal fraction (BPF) and CT using FreeSurfer.
Results: The global executive function score was related to the BPF (sß: 0.091, P<0.001) and CT in the right supramarginal (sß: 0.060, P=0.041) and right isthmus cingulate (sß: 0.062, P=0.011) regions. Literal verbal fluency was related to the BPF (sß: 0.125, P<0.001) and CT in the left parsorbitalis region (sß: 0.045, P=0.045). Semantic verbal fluency was related to the BPF (sß: 0.101, P<0.001) and CT in the right supramarginal region (sß: 0.061, P=0.042). The time difference between the TMT parts B and A was related to the BPF (sß: 0.048, P=0.045) and CT in the right precuneus (sß: 0.073, P=0.019) and right isthmus cingulate region (sß: 0.054, P=0.032).
Conclusions: In a large clinically based cohort of participants presenting with either MCI or SCC (a potential early stage of Alzheimer's disease [AD]), ED was related to the BPF and CT in the left pars orbitalis, right precuneus, right supramarginal, and right isthmus cingulate regions. This pattern of lesions adds knowledge to the conventional anatomy of ED and could contribute to the early diagnosis of AD.
{"title":"The pattern of cortical thickness associated with executive dysfunction in MCI and SCC: The MEMENTO cohort.","authors":"D Andriuta, M Roussel, G Chene, C Fischer, J-F Mangin, B Dubois, B Vellas, F Pasquier, F Tison, F Blanc, O Hanon, C Paquet, A Gabelle, M Ceccaldi, C Annweiler, P Krolak-Salmon, R David, I Rouch-Leroyer, A Benetos, O Moreaud, F Sellal, I Jalenques, P Vandel, V Bouteloup, O Godefroy","doi":"10.1016/j.neurol.2024.02.394","DOIUrl":"https://doi.org/10.1016/j.neurol.2024.02.394","url":null,"abstract":"<p><strong>Background: </strong>The association between the pattern of cortical thickness (CT) and executive dysfunction (ED) in mild cognitive impairment (MCI) and subjective cognitive complaints (SCC) is still poorly understood. We aimed to investigate the association between CT and ED in a large French cohort (MEMENTO) of 2323 participants with MCI or SCC.</p><p><strong>Methods: </strong>All participants with available CT and executive function data (verbal fluency and Trail Making Test [TMT]) were selected (n=1924). Linear regressions were performed to determine relationships between executive performance and the brain parenchymal fraction (BPF) and CT using FreeSurfer.</p><p><strong>Results: </strong>The global executive function score was related to the BPF (sß: 0.091, P<0.001) and CT in the right supramarginal (sß: 0.060, P=0.041) and right isthmus cingulate (sß: 0.062, P=0.011) regions. Literal verbal fluency was related to the BPF (sß: 0.125, P<0.001) and CT in the left parsorbitalis region (sß: 0.045, P=0.045). Semantic verbal fluency was related to the BPF (sß: 0.101, P<0.001) and CT in the right supramarginal region (sß: 0.061, P=0.042). The time difference between the TMT parts B and A was related to the BPF (sß: 0.048, P=0.045) and CT in the right precuneus (sß: 0.073, P=0.019) and right isthmus cingulate region (sß: 0.054, P=0.032).</p><p><strong>Conclusions: </strong>In a large clinically based cohort of participants presenting with either MCI or SCC (a potential early stage of Alzheimer's disease [AD]), ED was related to the BPF and CT in the left pars orbitalis, right precuneus, right supramarginal, and right isthmus cingulate regions. This pattern of lesions adds knowledge to the conventional anatomy of ED and could contribute to the early diagnosis of AD.</p>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141311600","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.08.019
V. Laguitton , M. Boutin , H. Brissart , D. Breuillard , M. Bilger , N. Forthoffer , V. Guinet , S. Hennion , C. Kleitz , H. Mirabel , C. Mosca , S. Pradier , S. Samson , V. Voltzenlogel , M. Planton , M. Denos , C. Bulteau
Neuropsychological assessment is a mandatory part of the pre- and post-operative evaluation in pediatric epilepsy surgery. The neuropsychology task force of the ILAE - French Chapter aims to define a neuropsychological procedure consensus based on literature review and adapted for French practice. They performed a systematic review of the literature published between 1950 and 2023 on cognitive evaluation of individuals undergoing presurgical work-up and post-surgery follow-up and focused on the pediatric population aged 6–16. They classified publications listed in the PubMed database according to their level of scientific evidence. The systematic literature review revealed no study with high statistical power and only four studies using neuropsychological scales in their French version. Afterwards, the experts defined a neuropsychological consensus strategy in pediatric epilepsy surgery according to the psychometric determinants of cognitive tests, specificity of epilepsy, surgery context, French culture and literature reports. A common French neuropsychological procedure dedicated to pediatric epilepsy surgery is now available. This procedure could serve as a guide for the pre- and post-surgical work-up in French centers with pediatric epilepsy surgery programs. The main goal is to anticipate the functional risks of surgery, to support the postoperative outcome beyond the seizure-related one, while taking into consideration the plasticity and vulnerability of the immature brain and allowing the possibility of collaborative studies.
{"title":"Neuropsychological assessment in pediatric epilepsy surgery: A French procedure consensus","authors":"V. Laguitton , M. Boutin , H. Brissart , D. Breuillard , M. Bilger , N. Forthoffer , V. Guinet , S. Hennion , C. Kleitz , H. Mirabel , C. Mosca , S. Pradier , S. Samson , V. Voltzenlogel , M. Planton , M. Denos , C. Bulteau","doi":"10.1016/j.neurol.2023.08.019","DOIUrl":"10.1016/j.neurol.2023.08.019","url":null,"abstract":"<div><p>Neuropsychological assessment is a mandatory part of the pre- and post-operative evaluation in pediatric epilepsy surgery. The neuropsychology task force of the ILAE - French Chapter aims to define a neuropsychological procedure consensus based on literature review and adapted for French practice. They performed a systematic review of the literature published between 1950 and 2023 on cognitive evaluation of individuals undergoing presurgical work-up and post-surgery follow-up and focused on the pediatric population aged 6–16. They classified publications listed in the PubMed database according to their level of scientific evidence. The systematic literature review revealed no study with high statistical power and only four studies using neuropsychological scales in their French version. Afterwards, the experts defined a neuropsychological consensus strategy in pediatric epilepsy surgery according to the psychometric determinants of cognitive tests, specificity of epilepsy, surgery context, French culture and literature reports. A common French neuropsychological procedure dedicated to pediatric epilepsy surgery is now available. This procedure could serve as a guide for the pre- and post-surgical work-up in French centers with pediatric epilepsy surgery programs. The main goal is to anticipate the functional risks of surgery, to support the postoperative outcome beyond the seizure-related one, while taking into consideration the plasticity and vulnerability of the immature brain and allowing the possibility of collaborative studies.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72210613","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2024.02.384
P. Corcia , P. Couratier
{"title":"Spreading of motor neuron degeneration in ALS is not so random","authors":"P. Corcia , P. Couratier","doi":"10.1016/j.neurol.2024.02.384","DOIUrl":"10.1016/j.neurol.2024.02.384","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140013205","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.07.007
T. Siddiqui, L.K. Bhatt
Synucleopathies, specifically Parkinson's disease, are still incurable and available therapeutic options are scarce and symptomatic. The autophagy-lysosomal-endosomal system is an indigenous mechanism to manage the proteome. Excess/misfolded protein accumulation activates this system, which degrades the undesired proteins via lysosomes. Cells also eliminate these proteins by releasing them into the extracellular space via exosomes. However, the sutophagy-lysosomal-endosomal system becomes unfunctional in Parkinson's disease and there is accumulation and spread of pathogenic alpha-synuclein. Neuronal degeneration results Owing to pathogenic alpha-synuclein. Thus, the autophagy-lysosomal-endosomal system could be a promising target for neuroprotection. In the present review, we discuss the autophagy-lysosomal-endosomal system as an emerging target for the management of Parkinson's disease. Modulation of these targets associated with the autophagy-lysosomal-endosomal system can aid in clearing pathogenic alpha-synuclein and prevent the degeneration of neurons.
{"title":"Emerging autophagic endo-lysosomal targets in the management of Parkinson's disease","authors":"T. Siddiqui, L.K. Bhatt","doi":"10.1016/j.neurol.2023.07.007","DOIUrl":"10.1016/j.neurol.2023.07.007","url":null,"abstract":"<div><p>Synucleopathies, specifically Parkinson's disease, are still incurable and available therapeutic options are scarce and symptomatic. The autophagy-lysosomal-endosomal system is an indigenous mechanism to manage the proteome. Excess/misfolded protein accumulation activates this system, which degrades the undesired proteins via lysosomes. Cells also eliminate these proteins by releasing them into the extracellular space via exosomes. However, the sutophagy-lysosomal-endosomal system becomes unfunctional in Parkinson's disease and there is accumulation and spread of pathogenic alpha-synuclein. Neuronal degeneration results Owing to pathogenic alpha-synuclein. Thus, the autophagy-lysosomal-endosomal system could be a promising target for neuroprotection. In the present review, we discuss the autophagy-lysosomal-endosomal system as an emerging target for the management of Parkinson's disease. Modulation of these targets associated with the autophagy-lysosomal-endosomal system can aid in clearing pathogenic alpha-synuclein and prevent the degeneration of neurons.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10367816","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.11.002
A. Ter Schiphorst , A. Lippi , L. Corti , I. Mourand , P. Prin , A. Agullo , F. Cagnazzo , J.-C. Macia , C. Arquizan
Introduction
Patent foramen ovale (PFO) is present in a significant proportion of young patients with stroke of undetermined etiology, but is not always causal. Therefore, classifications (RoPE, PASCAL) have been developed to determine the probability that PFO is the stroke cause. However, the presence of an initial arterial occlusion as a prediction factor was not studied when these classifications were built. Our aim was to evaluate the presence of arterial occlusion in young patients with stroke of undetermined etiology with/without high-risk PFO.
Methods
From a prospectively-built monocentric database, we identified patients aged ≥ 18 to < 60-years with strokes of undetermined etiology and complete etiological work-up, including transesophageal echocardiography. We divided patients in two groups: (i) with high-risk PFO [i.e. PFO with large interatrial shunt (> 30 microbubbles) or associated with atrial septal aneurysm] and (ii) with low-risk/without PFO. We recorded the presence of arterial occlusion and large vessel occlusion (LVO) in the acute phase.
Results
We included 96 patients; 55 (57%) had high-risk PFO. Their median age was 48 (40–52) years, and 28 (29%) were women. The percentages of patients with arterial occlusion and with LVO were lower in the high-risk PFO group than in the low-risk/without PFO group: 11 (20%) versus 19 (46%) (P = 0.008), and 5 (9%) versus 15 (37%) (P = 0.002), respectively. There was no difference in the median RoPE score between groups (P = 0.30).
Conclusion
The presence of LVO could represent a “red flag” of PFO causality in stroke of undetermined etiology, and could be implemented in future PFO-related stroke classifications.
{"title":"In young patients with stroke of undetermined etiology, large vessel occlusions are less frequent in the group with high-risk patent foramen ovale","authors":"A. Ter Schiphorst , A. Lippi , L. Corti , I. Mourand , P. Prin , A. Agullo , F. Cagnazzo , J.-C. Macia , C. Arquizan","doi":"10.1016/j.neurol.2023.11.002","DOIUrl":"10.1016/j.neurol.2023.11.002","url":null,"abstract":"<div><h3>Introduction</h3><p>Patent foramen ovale (PFO) is present in a significant proportion of young patients with stroke of undetermined etiology, but is not always causal. Therefore, classifications (RoPE, PASCAL) have been developed to determine the probability that PFO is the stroke cause. However, the presence of an initial arterial occlusion as a prediction factor was not studied when these classifications were built. Our aim was to evaluate the presence of arterial occlusion in young patients with stroke of undetermined etiology with/without high-risk PFO.</p></div><div><h3>Methods</h3><p>From a prospectively-built monocentric database, we identified patients aged<!--> <!-->≥<!--> <!-->18 to<!--> <!--><<!--> <!-->60-years with strokes of undetermined etiology and complete etiological work-up, including transesophageal echocardiography. We divided patients in two groups: (i) with high-risk PFO [i.e. PFO with large interatrial shunt (><!--> <!-->30 microbubbles) or associated with atrial septal aneurysm] and (ii) with low-risk/without PFO. We recorded the presence of arterial occlusion and large vessel occlusion (LVO) in the acute phase.</p></div><div><h3>Results</h3><p>We included 96 patients; 55 (57%) had high-risk PFO. Their median age was 48 (40–52) years, and 28 (29%) were women. The percentages of patients with arterial occlusion and with LVO were lower in the high-risk PFO group than in the low-risk/without PFO group: 11 (20%) versus 19 (46%) (<em>P</em> <!-->=<!--> <!-->0.008), and 5 (9%) versus 15 (37%) (<em>P</em> <!-->=<!--> <!-->0.002), respectively. There was no difference in the median RoPE score between groups (<em>P</em> <!-->=<!--> <!-->0.30).</p></div><div><h3>Conclusion</h3><p>The presence of LVO could represent a “red flag” of PFO causality in stroke of undetermined etiology, and could be implemented in future PFO-related stroke classifications.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138714642","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2024.05.002
F. Sellal
{"title":"Tribute to Maurice Collard (1931–2024)","authors":"F. Sellal","doi":"10.1016/j.neurol.2024.05.002","DOIUrl":"10.1016/j.neurol.2024.05.002","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S0035378724005289/pdfft?md5=7cbcb58f725f7d0b19c7204cab2f9d8c&pid=1-s2.0-S0035378724005289-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141080949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.09.006
M. Dhoisne , A. Delval , D. Mathieu , A. Mazeraud , L. Bournisien , P. Derambure , R. Tortuyaux
Background
Management of status epilepticus (SE) is focused on the early seizure termination. Refractory SE is an indication for sedation in patients with SE, but up to 75% of patients may be ventilated due to a neurological or respiratory failure. In patients requiring sedation, the clinical assessment is not sufficient to assess seizure control. Identifying those at risk of recurrent seizures could be useful to adapt their management. On the other hand, patients with low risk could benefit from an early withdrawal of sedation to avoid the impact of inappropriate sedation on outcome.
Objective
To determine the prevalence and the predictors of uncontrolled SE and its impact on outcome in patients with generalized convulsive SE (GCSE) requiring mechanical ventilation (MV).
Methods
We retrospectively included patients admitted to the intensive care unit with GCSE requiring MV. Uncontrolled SE was defined as persistent or recurrent seizures during sedation or within 24 hours following withdrawal. A multivariable logistic regression model was used to assess the associated factors.
Results
Uncontrolled SE occurred in 37 out of 220 patients (17%). Persistent seizures at admission, higher SAPS II and central nervous system infection were associated with a higher risk of uncontrolled SE. Acute toxic or metabolic etiologies were associated with a decreased risk of uncontrolled SE. In a supplementary analysis, decrease of albumin blood levels was associated with uncontrolled SE. Uncontrolled SE was associated with a poor functional outcome and mortality at 90 days.
Conclusions
Seventeen percent of patients with a GCSE requiring MV suffered from uncontrolled SE. Etiology and persistent seizures at admission were the main predictors of uncontrolled SE. Patients with uncontrolled SE had a longer duration of sedation and MV, a poor functional outcome and a higher mortality. Further studies are required to determine the impact of continuous electroencephalogram monitoring on the clinical course.
背景:癫痫状态(SE)的治疗重点在于尽早终止发作。难治性 SE 是 SE 患者镇静的指征,但多达 75% 的患者可能因神经或呼吸衰竭而需要通气。对于需要使用镇静剂的患者,临床评估不足以评估癫痫发作的控制情况。识别有复发风险的患者有助于调整对他们的管理。另一方面,低风险患者可受益于尽早撤除镇静剂,以避免不适当的镇静剂对预后产生影响:目的:确定需要机械通气(MV)的全身惊厥性 SE(GCSE)患者中未控制 SE 的发生率、预测因素及其对预后的影响:我们回顾性地纳入了重症监护病房收治的需要机械通气的全身抽搐性休克(GCSE)患者。无法控制的 SE 被定义为镇静期间或停药后 24 小时内的持续或反复发作。采用多变量逻辑回归模型评估相关因素:220例患者中有37例(17%)出现了无法控制的癫痫发作。入院时癫痫持续发作、SAPS II较高和中枢神经系统感染与SE失控风险较高有关。急性中毒或代谢性病因与 SE 不受控制的风险降低有关。在一项补充分析中,白蛋白血药浓度下降与 SE 不受控制有关。未控制的SE与功能预后差和90天后的死亡率有关:结论:在需要进行 MV 的 GCSE 患者中,17% 患有未受控制的 SE。病因和入院时癫痫持续发作是预测 SE 不受控制的主要因素。SE 不受控制的患者镇静和 MV 持续时间较长,功能预后较差,死亡率较高。需要进一步研究确定持续脑电图监测对临床过程的影响。
{"title":"Seizure recurrences in generalized convulsive status epilepticus under sedation: What are its predictors and its impact on outcome?","authors":"M. Dhoisne , A. Delval , D. Mathieu , A. Mazeraud , L. Bournisien , P. Derambure , R. Tortuyaux","doi":"10.1016/j.neurol.2023.09.006","DOIUrl":"10.1016/j.neurol.2023.09.006","url":null,"abstract":"<div><h3>Background</h3><p>Management of status epilepticus (SE) is focused on the early seizure termination. Refractory SE is an indication for sedation in patients with SE, but up to 75% of patients may be ventilated due to a neurological or respiratory failure. In patients requiring sedation, the clinical assessment is not sufficient to assess seizure control. Identifying those at risk of recurrent seizures could be useful to adapt their management. On the other hand, patients with low risk could benefit from an early withdrawal of sedation to avoid the impact of inappropriate sedation on outcome.</p></div><div><h3>Objective</h3><p>To determine the prevalence and the predictors of uncontrolled SE and its impact on outcome in patients with generalized convulsive SE (GCSE) requiring mechanical ventilation (MV).</p></div><div><h3>Methods</h3><p>We retrospectively included patients admitted to the intensive care unit with GCSE requiring MV. Uncontrolled SE was defined as persistent or recurrent seizures during sedation or within 24<!--> <!-->hours following withdrawal. A multivariable logistic regression model was used to assess the associated factors.</p></div><div><h3>Results</h3><p>Uncontrolled SE occurred in 37 out of 220 patients (17%). Persistent seizures at admission, higher SAPS II and central nervous system infection were associated with a higher risk of uncontrolled SE. Acute toxic or metabolic etiologies were associated with a decreased risk of uncontrolled SE. In a supplementary analysis, decrease of albumin blood levels was associated with uncontrolled SE. Uncontrolled SE was associated with a poor functional outcome and mortality at 90 days.</p></div><div><h3>Conclusions</h3><p>Seventeen percent of patients with a GCSE requiring MV suffered from uncontrolled SE. Etiology and persistent seizures at admission were the main predictors of uncontrolled SE. Patients with uncontrolled SE had a longer duration of sedation and MV, a poor functional outcome and a higher mortality. Further studies are required to determine the impact of continuous electroencephalogram monitoring on the clinical course.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138488347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.05.003
A. Espanol , F. Lerebours , L. Calviere , F. Bonneville , A. Ducros , V. Larrue , C. Gollion
Background
While migraine, particularly migraine with aura, is a recognized risk factor for ischemic stroke, the association of migraine with silent brain infarction is a matter of debate, as studies on this topic have yielded conflicting results.
Methods
A systematic review of the literature was conducted of studies reporting migraine and silent brain infarction, assessed by magnetic resonance imaging, between January 1980 and April 2022, by consulting Medline and Embase databases. Studies with a control group were included in a meta-analysis of population-based studies. An exploratory meta-analysis of both population-based and clinical-based studies was further performed to test the association between migraine with aura and silent brain infarction.
Results
A total of 2,408 articles were identified, among which 24 were included in the systematic review and 10 in the meta-analysis. The meta-analysis of population-based studies showed no association of migraine with silent brain infarction (odds ratio (OR) = 1.32 [95% CI 0.92;1.90], P = 0.13) and migraine with aura with silent brain infarction (OR = 1.56 [0.74;3.30], P = 0.24). However, in the exploratory meta-analysis of population-based and clinical-based studies, migraine with aura was significantly associated with silent brain infarction (OR = 1.91 [1.02;3.59], P = 0.04) and to silent cerebellar infarcts (OR = 2.57 [1.01;6.56], P = 0.05).
Conclusion
In this updated systematic review and meta-analysis of population-based studies, migraine and migraine with aura were not associated with silent brain infarction.
{"title":"Silent brain infarct in migraine: Systematic review and meta-analysis","authors":"A. Espanol , F. Lerebours , L. Calviere , F. Bonneville , A. Ducros , V. Larrue , C. Gollion","doi":"10.1016/j.neurol.2023.05.003","DOIUrl":"10.1016/j.neurol.2023.05.003","url":null,"abstract":"<div><h3>Background</h3><p><span>While migraine, particularly migraine with aura, is a recognized risk factor for </span>ischemic stroke<span>, the association of migraine with silent brain infarction is a matter of debate, as studies on this topic have yielded conflicting results.</span></p></div><div><h3>Methods</h3><p>A systematic review of the literature was conducted of studies reporting migraine and silent brain infarction, assessed by magnetic resonance imaging, between January 1980 and April 2022, by consulting Medline and Embase databases. Studies with a control group were included in a meta-analysis of population-based studies. An exploratory meta-analysis of both population-based and clinical-based studies was further performed to test the association between migraine with aura and silent brain infarction.</p></div><div><h3>Results</h3><p>A total of 2,408 articles were identified, among which 24 were included in the systematic review and 10 in the meta-analysis. The meta-analysis of population-based studies showed no association of migraine with silent brain infarction (odds ratio (OR)<!--> <!-->=<!--> <!-->1.32 [95% CI 0.92;1.90], <em>P</em> <!-->=<!--> <!-->0.13) and migraine with aura with silent brain infarction (OR<!--> <!-->=<!--> <!-->1.56 [0.74;3.30], <em>P</em> <!-->=<!--> <!-->0.24). However, in the exploratory meta-analysis of population-based and clinical-based studies, migraine with aura was significantly associated with silent brain infarction (OR<!--> <!-->=<!--> <!-->1.91 [1.02;3.59], <em>P</em> <!-->=<!--> <!-->0.04) and to silent cerebellar infarcts (OR<!--> <!-->=<!--> <!-->2.57 [1.01;6.56], <em>P</em> <!-->=<!--> <!-->0.05).</p></div><div><h3>Conclusion</h3><p>In this updated systematic review and meta-analysis of population-based studies, migraine and migraine with aura were not associated with silent brain infarction.</p></div>","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41164890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-06-01DOI: 10.1016/j.neurol.2023.11.006
M. Kandemir Yilmaz
{"title":"The effect of gabapentin and pregabalin on agitation in dementia: Case series of ten patients","authors":"M. Kandemir Yilmaz","doi":"10.1016/j.neurol.2023.11.006","DOIUrl":"10.1016/j.neurol.2023.11.006","url":null,"abstract":"","PeriodicalId":21321,"journal":{"name":"Revue neurologique","volume":null,"pages":null},"PeriodicalIF":3.0,"publicationDate":"2024-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139677862","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}