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2019 12th Biomedical Engineering International Conference (BMEiCON)最新文献

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Voltammetry based disposable sensor for antibiotic contamination in food 基于伏安法的一次性食品抗生素污染传感器
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990286
Yingyot Poo-arpom, S. Pakapongpan, Pitirat Pholpabu, Rungtiva P. Poo-arpom
This research work reported a highly selective and stable chloramphenicol sensor based on cyclic voltammetry. The sensor was fabricated using graphene-iron oxide nanoparticles modified on a magnetic screen-printed electrode (MSPE). The nanocomposite has remarkable enhancement in large surface areas, facilitates electron transfer to electrode surfaces, and possesses superparamagnetism property. The electrochemical properties were characterized by cyclic voltammetry (CV). The modified electrode provided a fast electron transfer with an apparent electron transfer rate constant (ks) of 0.88 s−1. The proposed biosensor showed fast CV response (3 s) to chloramphenicol with a wide linear range from 0.05 to 0.5 mM, a low detection limit of 17 μM at a signal to noise ratio of 3 (S/N=3), and good sensitivity (22.788 μA/μM). The resulted biosensor also showed high stability and good reproducibility.
本研究报道了一种基于循环伏安法的高选择性、稳定的氯霉素传感器。该传感器是用石墨烯-氧化铁纳米颗粒在磁丝网印刷电极(MSPE)上修饰而成的。该纳米复合材料在大表面积上具有显著的增强作用,有利于电子向电极表面转移,并具有超顺磁性。采用循环伏安法(CV)对其电化学性能进行了表征。修饰电极的电子转移速度快,表观电子转移速率常数(ks)为0.88 s−1。该传感器在0.05 ~ 0.5 mM范围内具有较宽的线性范围,CV响应速度快(3 s),信噪比为3 (s /N=3)时检测限低至17 μM,灵敏度为22.788 μA/μM。所制备的生物传感器稳定性高,重现性好。
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引用次数: 1
Microwave Ablation Multi-Antennas Operation studying for Hepatic Cancer Microwave Ablation Treatment system using 3D-Finite Element Analysis 基于三维有限元分析的肝癌微波消融治疗系统多天线工作研究
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990188
Teerasak Wongkedsada, P. Phasukkit
In our country, many people need appropriate treatment from hepatic cancer. Most of them still get the traditional method treatment which is high cost and too risky. Microwave ablation treatment is used microwave heat to eliminate cancer which is one of the other choices. However, it still needs to limit the area of heat dissipation. To prevent microwave heat destroy other organs. So, this research intends to present the analysis of double antenna variable setting and microwave system designing for appropriated heat to eliminate hepatic cancer by 3D finite element analysis in vitro experiment pattern. In the experiment, the open-tip antennas will be used and placed in parallel. The experiment will study the appropriate determination of each antenna switching time and power transmitting value. Moreover, there is an experiment with other two different types of antenna, slot, and slot with insulating jacket. The result shows that double antennas with different operating time and power cause heat to destroy hepatic cancer cells which can determine the size and has a geometric shape as desired. This technology can be applied to the treatment of hepatic cancer that has an asymmetrical shape.
在我国,许多肝癌患者需要适当的治疗。他们中的大多数人仍然采用传统的治疗方法,这种方法成本高,风险大。微波消融术是利用微波来消除肿瘤,是另一种选择。但是,它仍然需要限制散热面积。防止微波热破坏其他器官。因此,本研究拟通过体外实验模式的三维有限元分析,对双天线变量设置和微波系统设计进行分析,以适当的热量消除肝癌。在实验中,开尖天线将被平行放置。本实验将研究各天线切换时间和功率发射值的适当确定。此外,还对另外两种不同类型的天线,槽型和带绝缘护套的槽型进行了实验。结果表明,不同工作时间和功率的双天线对肝癌细胞产生的热破坏可以确定肝癌细胞的大小,并具有理想的几何形状。该技术可应用于形状不对称的肝癌的治疗。
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引用次数: 2
Classification of White blood cell using Deep Convolutional Neural Network 基于深度卷积神经网络的白细胞分类
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990301
Kan Throngnumchai, Pitchayakorn Lomvisai, Chayanan Tantasirin, P. Phasukkit
White blood cells are the one of immune system that are involved in protecting the body against infection disease and foreign invaders. There are difference category of white blood cell and each category can indicate about the irregularity of body. Nowadays, White blood cell diagnosis is usually examined manually by doctor. This process consumes a lot time, cost and susceptible to error compare with automatic computerize process. An automatic classification technique for microscopic white blood cell images focusing on images from fresh blood smears[1] is proposed in this paper. The classification is conducted using a proposed method that consist of deep convolutional neural network (DCNN). 10,000 Microscopic blood images were tested and the classification method obtain 93%
白细胞是免疫系统的一种,参与保护身体免受感染疾病和外来入侵者的侵害。白细胞有不同的种类,每一种类都能反映机体的不规则性。目前,白细胞诊断通常由医生手工检查。与计算机自动化加工相比,该工艺耗时长、成本高、易出错。提出了一种以新鲜血液涂片[1]图像为中心的显微白细胞图像自动分类技术。本文提出了一种基于深度卷积神经网络(DCNN)的分类方法。对1万张显微血液图像进行测试,分类方法获得93%
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引用次数: 9
Novel Protein-Protein Interaction Network of Antipsychotic Drugs and Cognitive Function 抗精神病药物与认知功能的新型蛋白-蛋白相互作用网络
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990302
K. Thanontip, B. Chetsawang, Vasunun Chumchua
Cognitive function is the intellectual activity of mental processes, such as, attention, processing speed, learning and memory, executive function, verbal fluency, and working memory. Cognitive deficits may contribute to functional disability in psychiatric disorders. Therefore, improving cognitive function has the potential to enhance the quality of life and occupational capacity, and reduce disease problems and societal costs. Recent evidence emphasized that conventional antipsychotics effective in treating positive symptoms but have almost no therapeutic benefit on cognitive impairment and produce a poor functional outcome. It has been hypothesized that antipsychotics might induce cognitive impairment or decline in psychiatric disorders. Therefore, this study aims to elucidate the network of proteins that may involve in antipsychotic drug-induced cognitive impairment. The results of GeneCards analysis showed 213 target genes of commonly use antipsychotics in schizophrenia, 122 genes associated with cognitive function in schizophrenia, and 28 genes related to antipsychotics and cognitive function in schizophrenia. Protein-protein interaction (PPI) network of 12 significantly interconnected proteins was generated by the PPI network analysis and clustering method. The 16 significant pathways related to antipsychotic drugs and cognitive function were identified using pathway grouped network analysis. These results demonstrate clue evidence to discover novel target sites of action of antipsychotics that might play a pivotal role in cognitive deficits in schizophrenia.
认知功能是心理过程的智力活动,如注意力、处理速度、学习和记忆、执行功能、语言流畅性和工作记忆。认知缺陷可能导致精神疾病的功能性残疾。因此,改善认知功能有可能提高生活质量和职业能力,减少疾病问题和社会成本。最近的证据强调,传统的抗精神病药物对治疗阳性症状有效,但对认知障碍几乎没有治疗效果,并产生不良的功能结果。据推测,抗精神病药物可能会导致认知障碍或精神疾病的下降。因此,本研究旨在阐明可能涉及抗精神病药物引起的认知障碍的蛋白质网络。GeneCards分析结果显示,精神分裂症常用抗精神病药物靶基因213个,与精神分裂症认知功能相关基因122个,与精神分裂症抗精神病药物和认知功能相关基因28个。通过蛋白质相互作用(PPI)网络分析和聚类方法,生成了12个相互作用显著的蛋白质的蛋白质相互作用网络。采用通路分组网络分析方法,鉴定出抗精神病药物与认知功能相关的16条重要通路。这些结果为发现抗精神病药物可能在精神分裂症认知缺陷中起关键作用的新靶点提供了线索证据。
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引用次数: 0
Metal Artifact Recognition using Deep Convolutional Neural Network in Abdomen and Pelvis CT Image 基于深度卷积神经网络的腹部和骨盆CT图像金属伪影识别
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990331
Rattasart Sakunrat, Kongphum Arthamanolap, P. Phasukkit
In medicine, radiotherapy image obtained from CT or MRI is an important part in planning to find dosage for radiation treatment for cancer patients. Those images that obtained from CT may have artifacts caused by many factors such as motion artifact, metal artifact, scatter, ring artifact, pseudo enhancement and cone beam effect which is a component that makes image analysis worse. For improvement the quality of image that have artifact, image processing technique is used to manage and reduce it before bring to apply in radiotherapy of medicine. However, for finding the artifacts of 3D image is so difficultly and take more time because 3D image has to split into 2D image before. The aim of this research is to identify the artifact noise in 2D slice by using Deep Convolutional Neural Network (DCNN) model of metal artifact for reduce time. In this experiment have divided dataset into two types of image include 100 image of artifacts and 100 image Non-artifacts for training and 20 images for testing. The result has been shown that accuracy of artifacts and Non-artifacts are 76% and 62.28% respectively. In addition, this studied has found that a small amount of data from Thailand individual results in less accuracy.
在医学上,从CT或MRI获得的放疗图像是规划癌症患者放射治疗剂量的重要组成部分。从CT中获得的图像可能存在由多种因素引起的伪影,如运动伪影、金属伪影、散射、环形伪影、伪增强和锥束效应等,而锥束效应是影响图像分析的一个重要因素。为了提高有伪影的图像质量,在应用于医学放射治疗之前,采用图像处理技术对伪影进行处理和降低。然而,由于三维图像必须先分割成二维图像,因此寻找三维图像的伪影非常困难且耗时较长。本研究的目的是利用金属伪影的深度卷积神经网络(DCNN)模型来识别二维切片中的伪影噪声,以减少时间。在本实验中,我们将数据集分为两类,其中100张人工图像和100张非人工图像用于训练,20张用于测试。结果表明,人工和非人工的准确率分别为76%和62.28%。此外,本研究还发现,来自泰国个体的少量数据结果准确性较低。
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引用次数: 0
Preparation of giant lipobeads using a gel-assisted swelling method 用凝胶辅助肿胀法制备巨脂球
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990310
Zugui Peng, K. Shimba, Y. Miyamoto, T. Yagi
Lipobeads are spherical vesicles of lipid membrane supported by a hydrogel core that hold promise as next-generation biosensors. However, previous methods for generating lipobeads had limitations due to the use of organic solvents and low ionic strength solutions. To overcome these limitations, we developed a method for forming lipobeads by using a gel-assisted swelling approach. Our results show that lipobeads form in osmotic strength solution and supposed to contain no residual organic solvent.
脂珠是由水凝胶核心支撑的脂质膜球形囊泡,有望成为下一代生物传感器。然而,由于使用有机溶剂和低离子强度溶液,以前生成脂珠的方法有局限性。为了克服这些限制,我们开发了一种通过凝胶辅助肿胀方法形成脂珠的方法。结果表明,脂粒是在渗透压溶液中形成的,不含有机溶剂残留。
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引用次数: 0
Tele-Operation of Robotic Arm 机械臂的远程操作
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990247
Manao Bunkum, Phakjira Vachirasakulchai, Jindapa Nampeng, Ramita Tommajaree, S. Visitsattapongse
This research is for facilitate the healthcare worker to approach patient that located in distant areas via internet. Also, patient need not to get to the city to see a doctor. Hence, this research will reduce time and cost of traveling. This research is to create tele-control robot arm, use in the operating room, which is controlled by joystick from anywhere. It is separated into 2 parts that is hardware part to design and print 3D robot arm and joystick and software part, which is code to control robot arm also send controlling data via internet. Furthermore, this project will send real-time video from robot arm to controller side. The data is sent between robot arm and joystick by nodeMCU or in this project use two ESP32, one will receive data from joystick and send the data to another for control robot arm. In the section of sending real-time video, this project use Raspberry pi as a device for sending.
本研究是为了方便医护人员通过互联网接近偏远地区的患者。此外,病人不需要去城市看医生。因此,这项研究将减少旅行的时间和成本。本课题是研制一种遥控机器人手臂,用于手术室,可在任何地方通过操纵杆进行控制。该系统分为硬件部分和软件部分,硬件部分是设计和打印3D机械臂和操纵杆,软件部分是控制机械臂的代码部分,软件部分是通过网络发送控制数据。此外,该项目将从机器人手臂发送实时视频到控制器端。通过nodeMCU在机械臂和操纵杆之间发送数据,或者在本项目中使用两个ESP32,一个接收来自操纵杆的数据并将数据发送给另一个控制机械臂。在实时视频发送部分,本项目使用树莓派作为发送设备。
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引用次数: 1
Automated Classification of Sleep Apnea and Hypopnea on Polysomnography Data 基于多导睡眠图数据的睡眠呼吸暂停和低通气的自动分类
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990338
Jyothsna Somanna, Deepika Joshi, Hiranmaya Gundu, G. Srinivasa
Polysomnography (PSG) is a sleep study where multiple parameters of a subject are continuously monitored to detect sleep disorders that can have adverse health effects. This study uses Machine Learning techniques to automatically detect and classify apneas and hypopneas in PSG data. By incorporating features that sleep analysts look for in PSG data we present a machine learning based approach to automatically detect the presence of hypopnea or apnea and classify the type of pathology. This paper presents a visualization of the PSG study, explicates the design of features and provides a comparison between the approaches of learning from the computed features versus the signal directly. Our results demonstrate that a hierarchical SVM model trained on a small set of features yields an accuracy of 82.6% with a high precision of 86%.
多导睡眠图(PSG)是一项睡眠研究,通过连续监测受试者的多个参数来检测可能对健康产生不利影响的睡眠障碍。本研究使用机器学习技术自动检测和分类PSG数据中的呼吸暂停和呼吸不足。通过结合睡眠分析师在PSG数据中寻找的特征,我们提出了一种基于机器学习的方法来自动检测呼吸不足或呼吸暂停的存在,并对病理类型进行分类。本文展示了PSG研究的可视化,阐述了特征的设计,并提供了从计算特征和直接从信号中学习的方法之间的比较。我们的结果表明,在一小组特征上训练的分层支持向量机模型的准确率为82.6%,高精度为86%。
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引用次数: 2
IR-UWB generate by FPGA for Non-contact Respiration Measurements 用于非接触呼吸测量的FPGA产生IR-UWB
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990190
Panupong Buasombat, Nonthakorn Pungpa, P. Phasukkit
Respiration rate detections and measurement has a benefit for elementary symptom in medical application. In present, most of respiration examination in medical field still needs to contact electrode with skin which is main still problem for some patient. Patients who got problem with skin like dermatitis or unable for contact case cause the problem for respiration rate detection. So, this research intends to design non-contact respiration measurement system for resolve this problem. The research applies impulse radio function with ultra-wideband wave (UWB) generate by field programmable gate array (FPGA) for detect respiration rate. In the experiment, we have designed the signal processing algorithm for respiration rate measurement by Fast-Fourier Transform (FFT) of doppler frequency from UWB detection. Result has compared respiration rate measurement between non-contact respiration rate by designed algorithm and standard contact respiration monitoring belt.
呼吸频率的检测和测量在医学上对初级症状的诊断有很大的帮助。目前,医学上大多数呼吸检查仍然需要电极与皮肤接触,这仍然是一些患者的主要问题。患有皮炎等皮肤问题或不能接触的患者会导致呼吸率检测出现问题。因此,本研究旨在设计非接触式呼吸测量系统来解决这一问题。该研究利用现场可编程门阵列(FPGA)产生的超宽带波(UWB)脉冲无线电功能检测呼吸速率。在实验中,我们设计了基于超宽带多普勒频率的快速傅立叶变换(FFT)测量呼吸速率的信号处理算法。结果将所设计的非接触呼吸率测量方法与标准的接触呼吸监测带进行了比较。
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引用次数: 0
Premixed Calcium Phosphate Cement for Extrusion-based 3D Printing: Planetary Centrifugal Mixer and Homogeneity Evaluation 预混磷酸钙水泥挤出为基础的3D打印:行星离心搅拌机和均匀性评价
Pub Date : 2019-11-01 DOI: 10.1109/BMEiCON47515.2019.8990241
Jirawat Iamsamang, Kititat Subannajui, Tulapruek Tawonsawatruk, P. Naiyanetr
Self-setting calcium phosphate cement (CPC), used in orthopedic surgery for bone replacement, usually consists of the powder mixture and setting liquid (aqueous) or carrier liquid (non-aqueous). After mixing two-phase compounds, the injectable viscous solution was formed and able to mold into the desired shape of the bone. The heterogeneous mixture, however, affects the dissolution-precipitation reaction ending in the unwanted chemical products, the deformed shape of solidified materials, and the undesired mechanical properties. In addition, the debris of heterogeneity increased the clogged needle probability when extruding with the cartridge of the 3D printer. In order to overcome these sort of problems and refine the homogeneity of CPC, the blade-free planetary mixer was used. Herein, the planetary centrifugal mixer was developed to increase the homogeneity of the CPC mixtures in batch production. The preliminary study of characteristics of the mixer, the revolution speed, centrifugal acceleration (1-66G), and their relations, was reported. The homogeneity of a CPC mixture was tested into two parts: the mixings of the powder-powder compound, and the powder-liquid paste. ImageJ, Fiji bundles, was used to evaluate the homogeneity of the mixture. The centrifugal acceleration of 16G and 66G homogeneously mixed a 1.2g of CaCO3/Orange Red 735 and a 1.5g of αTCP/Glycerine respectively within 3 minutes. This study intentionally contributed to the fields of bio-printing and biofabrication, especially artificial bone, by improving the mixing process of the bone cement formula and demonstrating the idea for industrializing the bone cement into the commercial product.
自凝磷酸钙骨水泥(CPC)用于骨科手术的骨置换,通常由粉末混合物和凝结液(含水)或载体液(非含水)组成。混合两相化合物后,可注射的粘性溶液形成,并能够塑造成所需的骨骼形状。然而,非均相混合物会影响溶解-沉淀反应,最终产生不需要的化学产物,凝固材料的变形形状和不希望的机械性能。此外,非均质碎屑增加了3D打印机墨盒挤压时堵塞针头的概率。为了克服这些问题,改善CPC的均匀性,采用了无叶片行星混合器。为了提高CPC混合料在批量生产中的均匀性,研制了行星式离心混合器。初步研究了混合机的特性、转速、离心加速度(1-66G)及其相互关系。将CPC混合物的均匀性分为两部分进行测试:粉末-粉末混合物和粉末-液体膏体的混合。ImageJ,斐济束,用于评价混合物的均匀性。在16G和66G的离心加速度下,分别将1.2g CaCO3/橙红色735和1.5g αTCP/甘油在3分钟内混合均匀。本研究通过改进骨水泥配方的混合工艺,并展示了将骨水泥工业化为商业产品的想法,有意为生物打印和生物制造领域做出贡献,特别是人工骨。
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引用次数: 1
期刊
2019 12th Biomedical Engineering International Conference (BMEiCON)
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