Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1972.TB00908.X
F. Bro-Rasmussen
Two groups of normal inbred female rats, aged 3 and 5–6 months, and three groups of germ-free female rats, aged 3, 5–6, and 10–11 months, received a single injection of tritiated thymidine. After varying intervals the rats were killed. The spleens were homogenized and suspended in physiological saline. The suspensions were studied for eosinophil count and the percentage of radioactively labelled eosinophils. The corresponding values for the spleens were calculated. At the same time the eosinophil cells and the labelling index in the peripheral blood were studied. The germ-free rats showed considerably lower counts in the blood and spleen than did the others. In all groups there was parallelism between eosinophils in the blood and in the spleen. All spleens exhibited eosinopoiesis and some parallelism between this activity and the circulating eosinophils. Splenectomy in control rats did not give rise to measurable changes in the number of circulating eosinophils. It is concluded that apart from being formed by local eosinopoiesis, the eosinophilic cells of the spleen have been transported by the blood and stored in the spleen. The function of the spleen as a depot of eosinophilic cells probably plays no major role. Splenic eosinopoiesis is not, and cannot be expected to be, of importance to the number of circulating eosinophils.
{"title":"Eosinopoiesis in the spleen of normal rats. Autoradiographic studies.","authors":"F. Bro-Rasmussen","doi":"10.1111/J.1600-0609.1972.TB00908.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1972.TB00908.X","url":null,"abstract":"Two groups of normal inbred female rats, aged 3 and 5–6 months, and three groups of germ-free female rats, aged 3, 5–6, and 10–11 months, received a single injection of tritiated thymidine. \u0000 \u0000 \u0000 \u0000After varying intervals the rats were killed. The spleens were homogenized and suspended in physiological saline. The suspensions were studied for eosinophil count and the percentage of radioactively labelled eosinophils. The corresponding values for the spleens were calculated. At the same time the eosinophil cells and the labelling index in the peripheral blood were studied. \u0000 \u0000 \u0000 \u0000The germ-free rats showed considerably lower counts in the blood and spleen than did the others. In all groups there was parallelism between eosinophils in the blood and in the spleen. \u0000 \u0000 \u0000 \u0000All spleens exhibited eosinopoiesis and some parallelism between this activity and the circulating eosinophils. \u0000 \u0000 \u0000 \u0000Splenectomy in control rats did not give rise to measurable changes in the number of circulating eosinophils. \u0000 \u0000 \u0000 \u0000It is concluded that apart from being formed by local eosinopoiesis, the eosinophilic cells of the spleen have been transported by the blood and stored in the spleen. The function of the spleen as a depot of eosinophilic cells probably plays no major role. Splenic eosinopoiesis is not, and cannot be expected to be, of importance to the number of circulating eosinophils.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"46 1","pages":"8-17"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78439112","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1975.TB02432.X
F. Mitelman, A. Panani, L. Brandt
In a patient with eosinophilic leukaemia, serial chromosome studies using the Giemsa banding technique revealed a similar marker chromosome, identified as an isochromosome 17, in all bone marrow metaphases analysed. There was no Ph-1-chromosome. The cytogenetic data support the view that eosinophilic leukaemia is a specific disease entity, and suggest that both eosinophilic and neutrophilic cells are involved in the leukaemic process.
{"title":"Isochromosome 17 in a case of eosinophilic leukaemia. An abnormality common to eosinophilic and neutrophilic cells.","authors":"F. Mitelman, A. Panani, L. Brandt","doi":"10.1111/J.1600-0609.1975.TB02432.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1975.TB02432.X","url":null,"abstract":"In a patient with eosinophilic leukaemia, serial chromosome studies using the Giemsa banding technique revealed a similar marker chromosome, identified as an isochromosome 17, in all bone marrow metaphases analysed. There was no Ph-1-chromosome. The cytogenetic data support the view that eosinophilic leukaemia is a specific disease entity, and suggest that both eosinophilic and neutrophilic cells are involved in the leukaemic process.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"124 1","pages":"308-12"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77329106","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1978.TB02495.X
J. Jansen, J. Hermans, J. Remme, G. J. Ottolander, P. Cardozo
Hairy-cell leukaemia (leukaemic reticuloendotheliosis) is a well-defined clinical entity. Most of the recent reports are almost entirely concerned with the pathological and functional aspects of the disease. In the present retrospective study the clinical features and laboratory data of 12 patients were analyzed together with a series of 123 adequately clinically documented cases from the literature. The Hb level and the sex of the patient proved to be the only parameters having some prognostic value for the survival time after diagnosis. The effect of splenectomy was assessed in two comparable groups of 24 splenectomized and 51 non-splenectomized patients. The operation seemed to be beneficial, but after 2 years the difference was not significant(.05 less than P less than .10). Analysis of subgroups showed that splenectomy was definitely beneficial in women, in patients with a Hb level over 8.0 g/dl or a platelet level above 50 X 10(9)/1, in patients with leucocytes below 3 X 10(9/1, , and also in patients with hepatomegaly (P less than .05 in all cases). These findings suggest that splenectomy is beneficial in cases where anaemia and thrombocytopenia are not very severe; in severe cytopenia the operation does not increase the life expectancy.
毛细胞白血病(白血病网状内皮增生症)是一个明确的临床实体。大多数最近的报告几乎完全关注疾病的病理和功能方面。在本回顾性研究中，我们分析了12例患者的临床特征和实验室资料，并从文献中收集了123例充分临床记录的病例。Hb水平和患者的性别被证明是诊断后生存时间具有一定预后价值的唯一参数。对24例脾切除术患者和51例未行脾切除术患者两组比较，评估脾切除术的效果。手术似乎是有益的，但2年后差异不显着。0.05 < P < 0.10)。亚组分析显示，脾切除术对女性、Hb水平高于8.0 g/dl或血小板水平高于50 X 10(9)/1的患者、白细胞水平低于3 X 10(9/1)的患者以及肝肿大的患者都是绝对有益的(所有病例的P < 0.05)。这些结果表明，脾切除术对贫血和血小板减少不是很严重的病例是有益的;在严重的细胞减少症中，手术不能延长预期寿命。
{"title":"Hairy cell leukaemia. Clinical features and effect of splenectomy.","authors":"J. Jansen, J. Hermans, J. Remme, G. J. Ottolander, P. Cardozo","doi":"10.1111/J.1600-0609.1978.TB02495.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1978.TB02495.X","url":null,"abstract":"Hairy-cell leukaemia (leukaemic reticuloendotheliosis) is a well-defined clinical entity. Most of the recent reports are almost entirely concerned with the pathological and functional aspects of the disease. In the present retrospective study the clinical features and laboratory data of 12 patients were analyzed together with a series of 123 adequately clinically documented cases from the literature. The Hb level and the sex of the patient proved to be the only parameters having some prognostic value for the survival time after diagnosis. The effect of splenectomy was assessed in two comparable groups of 24 splenectomized and 51 non-splenectomized patients. The operation seemed to be beneficial, but after 2 years the difference was not significant(.05 less than P less than .10). Analysis of subgroups showed that splenectomy was definitely beneficial in women, in patients with a Hb level over 8.0 g/dl or a platelet level above 50 X 10(9)/1, in patients with leucocytes below 3 X 10(9/1, , and also in patients with hepatomegaly (P less than .05 in all cases). These findings suggest that splenectomy is beneficial in cases where anaemia and thrombocytopenia are not very severe; in severe cytopenia the operation does not increase the life expectancy.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"99 1","pages":"60-71"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83380333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1969.TB02401.X
S. Blix
A simple and rapid method for evaluation of activator activity in patients during thrombolytic therapy-the activator time-is presented. It is based upon a clot lysis system with an euglobulin solution from normal plasma as substrate, but fibrinogen could also be used. The method may tell whether the patient is sufficiently treated or not, and the possibility of establishing a therapeutical range is suggested.
{"title":"The activator time. A method for control of activator activity during thrombolytic therapy.","authors":"S. Blix","doi":"10.1111/J.1600-0609.1969.TB02401.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1969.TB02401.X","url":null,"abstract":"A simple and rapid method for evaluation of activator activity in patients during thrombolytic therapy-the activator time-is presented. It is based upon a clot lysis system with an euglobulin solution from normal plasma as substrate, but fibrinogen could also be used. The method may tell whether the patient is sufficiently treated or not, and the possibility of establishing a therapeutical range is suggested.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"315 1","pages":"221-226"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77625838","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1981.TB01363.X
L. Rydgren, H. Brodin, C. Håkansson, A. Norberg, B. Norberg, C. Westrup
In vital preparations moving polymorphonuclear leucocytes (PMNs) disappear from the visual field. The present study provides evidence by means of geometrical analysis and computer simulation, that this disappearance is due to a heterogeneous distribution of the PMNs at the beginning of observation. The path of random-moving computer leucocytes is more tortuous than the path of comparable vital PMNs without obvious attractant, i.e. vital PMNs supposed to be random-moving. This finding is in agreement with the Allan-Wilkinson observation of 'persistent random walk' of vital cells.
{"title":"The computer leucocyte. Analysis of the random movement of leucocytes in a visual field by means of computer simulation.","authors":"L. Rydgren, H. Brodin, C. Håkansson, A. Norberg, B. Norberg, C. Westrup","doi":"10.1111/J.1600-0609.1981.TB01363.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1981.TB01363.X","url":null,"abstract":"In vital preparations moving polymorphonuclear leucocytes (PMNs) disappear from the visual field. The present study provides evidence by means of geometrical analysis and computer simulation, that this disappearance is due to a heterogeneous distribution of the PMNs at the beginning of observation. The path of random-moving computer leucocytes is more tortuous than the path of comparable vital PMNs without obvious attractant, i.e. vital PMNs supposed to be random-moving. This finding is in agreement with the Allan-Wilkinson observation of 'persistent random walk' of vital cells.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"43 1","pages":"45-50"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90785905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1968.TB01714.X
A. Bloom, A. Boyns, J. Wingfield
The clinical and laboratory features of a patient with the obstetric defibrination syndrome are described. The abnormal bleeding responded to fibrinogen therapy and epsilon-aminocaproic acid was not used. The patient's plasma contained little fibrinogen capable of clotting without protamine and it inhibited the thrombin clotting time of normal plasma. Increased fibrinolysis was not observed. Serum obtained from the plasma after addition of protamine and concentrated thrombin contained a substance which reacted with an anti-fibrin serum when tested by an immunoelectrophoretic technique. The results confirmed that ‘altered’ incoagulable fibrinogen determinants were present in the patient's blood which may have interfered with the thrombin-fibrinogen reaction. It is suggested that these changes may be due to intravascular coagulation and not only to fibrinogenolysis. Similar but less severe coagulation changes were observed in the infant's cord blood.
{"title":"Obstetric Defibrination Syndrome with Abnormal Thrombin‐Fibrinogen Reaction and Immunologically Reactive Altered Fibrinogen in Serum","authors":"A. Bloom, A. Boyns, J. Wingfield","doi":"10.1111/J.1600-0609.1968.TB01714.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1968.TB01714.X","url":null,"abstract":"The clinical and laboratory features of a patient with the obstetric defibrination syndrome are described. The abnormal bleeding responded to fibrinogen therapy and epsilon-aminocaproic acid was not used. The patient's plasma contained little fibrinogen capable of clotting without protamine and it inhibited the thrombin clotting time of normal plasma. Increased fibrinolysis was not observed. Serum obtained from the plasma after addition of protamine and concentrated thrombin contained a substance which reacted with an anti-fibrin serum when tested by an immunoelectrophoretic technique. The results confirmed that ‘altered’ incoagulable fibrinogen determinants were present in the patient's blood which may have interfered with the thrombin-fibrinogen reaction. It is suggested that these changes may be due to intravascular coagulation and not only to fibrinogenolysis. Similar but less severe coagulation changes were observed in the infant's cord blood.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"21 1","pages":"26-34"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87320665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1968.TB01760.X
E. Monn, P. Gaffney, H. Lehmann
Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability. Heterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.
{"title":"Haemoglobin Sogn (β14 Arginine) A New Haemoglobin Variant","authors":"E. Monn, P. Gaffney, H. Lehmann","doi":"10.1111/J.1600-0609.1968.TB01760.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1968.TB01760.X","url":null,"abstract":"Among 3,000 Norwegian individuals two haemoglobin variants were found. One was a Haemoglobin D Punjab. The other was a new variant, Haemoglobin Sogn, in which leucine is replaced by arginine at the internally sited residue 14 of the β chain. The haemoglobin variant shows a slight heat instability. \u0000 \u0000 \u0000 \u0000Heterozygotes for Haemoglobin Sogn show a small amount of free α chains in their haemolysates, but no Heinz bodies are present in their erythrocytes and they are clinically healthy.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"61 1","pages":"353-360"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85196557","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1981.TB01415.X
R. Barr, A. Davidson, L. K. Jung, K. R. Mohan Pai
Increased osmotic fragility and methaemoglobin generation in vitro have resulted from the exposure of normal human erythrocytes to numerous cancer chemotherapeutic agents. These findings offer a possible explanation for the earlier, consistent clinical observation of the rapid development of anaemia, during consolidation therapy, in children with acute lymphoblastic leukaemia in remission.
{"title":"Erythrocytotoxicity induced by cancer chemotherapeutic agents. In vitro studies of osmotic fragility and methaemoglobin generation.","authors":"R. Barr, A. Davidson, L. K. Jung, K. R. Mohan Pai","doi":"10.1111/J.1600-0609.1981.TB01415.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1981.TB01415.X","url":null,"abstract":"Increased osmotic fragility and methaemoglobin generation in vitro have resulted from the exposure of normal human erythrocytes to numerous cancer chemotherapeutic agents. These findings offer a possible explanation for the earlier, consistent clinical observation of the rapid development of anaemia, during consolidation therapy, in children with acute lymphoblastic leukaemia in remission.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"113 1","pages":"363-8"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76901886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1981.TB01391.X
B. Boneu, C. Nouvel, P. Sié, C. Caranobe, D. Combes, G. Laurent, J. Pris, R. Bierme
Certain platelet functions were evaluated in 24 patients with secondary polycythaemia (SP) and in a large number of patients suffering from myeloproliferative disorders (MD'S): 89 patients with chronic myeloid leukaemia (CML) at different stages of development, 58 with polycythaemia vera (PV), 23 with essential thrombocythaemia (ET), and 25 with agnogenic myeloid metaplasia (AMM). Bleeding time, epinephrine-induced platelet aggregation and adhesiveness agreed with those generally reported in the literature; they are independent of thrombocytosis, the haemoglobin level and the leucocyte count. Macrothrombocytosis, evaluated by an electronic method, was only found in CML, mainly during acute blast crisis. An increased percentage of light platelets was a constant feature in all groups except in the SP and in 20% of the PV. The most severe abnormalities were observed in AMM and CML in the acute stage; in the chronic phase of CML there is no correlation between the severity of platelet abnormalities and the survival of the patients.
{"title":"Platelets in myeloproliferative disorders. I. A comparative evaluation with certain platelet function tests.","authors":"B. Boneu, C. Nouvel, P. Sié, C. Caranobe, D. Combes, G. Laurent, J. Pris, R. Bierme","doi":"10.1111/J.1600-0609.1981.TB01391.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1981.TB01391.X","url":null,"abstract":"Certain platelet functions were evaluated in 24 patients with secondary polycythaemia (SP) and in a large number of patients suffering from myeloproliferative disorders (MD'S): 89 patients with chronic myeloid leukaemia (CML) at different stages of development, 58 with polycythaemia vera (PV), 23 with essential thrombocythaemia (ET), and 25 with agnogenic myeloid metaplasia (AMM). Bleeding time, epinephrine-induced platelet aggregation and adhesiveness agreed with those generally reported in the literature; they are independent of thrombocytosis, the haemoglobin level and the leucocyte count. Macrothrombocytosis, evaluated by an electronic method, was only found in CML, mainly during acute blast crisis. An increased percentage of light platelets was a constant feature in all groups except in the SP and in 20% of the PV. The most severe abnormalities were observed in AMM and CML in the acute stage; in the chronic phase of CML there is no correlation between the severity of platelet abnormalities and the survival of the patients.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"28 1","pages":"214-20"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78182635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1984.TB02176.X
C. Scott, A. G. Bynoe, D. Hough, B. Roberts
Expression of peripheral blood neutrophil (PBN) C3b receptors, as assessed by rosette formation with C3b-coated ox erythrocytes, was examined and compared with neutrophil alkaline phosphatase (NAP) activities in both normal and haematologically abnormal conditions. The results indicate that a small percentage of normal PBN are apparently C3b receptor-negative and that these neutrophils do not appear to differ with respect to age from those with detectable C3b receptors. Examination of PBN C3b receptors from 154 cases of various haematological disorders revealed a significant proportion of cases with increased numbers of C3b receptor-negative neutrophils. These abnormalities did not appear to be related to peripheral leucocyte counts, NAP activities or serum lysozyme concentrations and it is suggested that the increased numbers of C3b receptor-negative PBN may be related to intravascular factors such as immune complexes.
{"title":"C3b Receptor‐Negative Peripheral Blood Neutrophils","authors":"C. Scott, A. G. Bynoe, D. Hough, B. Roberts","doi":"10.1111/J.1600-0609.1984.TB02176.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1984.TB02176.X","url":null,"abstract":"Expression of peripheral blood neutrophil (PBN) C3b receptors, as assessed by rosette formation with C3b-coated ox erythrocytes, was examined and compared with neutrophil alkaline phosphatase (NAP) activities in both normal and haematologically abnormal conditions. The results indicate that a small percentage of normal PBN are apparently C3b receptor-negative and that these neutrophils do not appear to differ with respect to age from those with detectable C3b receptors. Examination of PBN C3b receptors from 154 cases of various haematological disorders revealed a significant proportion of cases with increased numbers of C3b receptor-negative neutrophils. These abnormalities did not appear to be related to peripheral leucocyte counts, NAP activities or serum lysozyme concentrations and it is suggested that the increased numbers of C3b receptor-negative PBN may be related to intravascular factors such as immune complexes.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"60 1","pages":"183-189"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75311499","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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