Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1984.TB02178.X
A. Singh, P. Lewis, G. Wetherley‐Mein
Lymphocyte surface markers (E-SRBC, EAC, EA gamma and SmIg) and monoclonal antibodies (OKT3, OKT4, OKT8 and OKIa) were used to characterise the blood and bone marrow lymphocytes of T-cell CLL (8 patients). The diagnosis of T-cell CLL was made primarily as the majority of blood lymphocytes formed E-SRBC in each patient. Other markers-EAC, EA gamma and SmIg--showed different patterns of association with E-SRBC. These findings considered together described 4 different phenotypes amongst these patients: (a) E+ (3 patients), (b) E+, EAC+ (1 patient), (c) E+, EA gamma + (2 patients), and (d) E+, SmIg+ (2 patients). Similarly, 4 different groups were defined with the help of monoclonal antibodies. Helper T-cell (3 patients) and suppressor T-cell (1 patient) CLL showed predominantly helper T- and suppressor T-lymphocytes respectively. Mixed T-cell CLL (1 patient) comprised an equal proportion of both subpopulations, while the remaining 3 patients, with excess of one or other subpopulations along with a considerable proportion of Ia antigen-bearing lymphocytes, formed the indeterminate cell type CLL.
采用淋巴细胞表面标记物(E-SRBC、EAC、EA γ和SmIg)和单克隆抗体(OKT3、OKT4、OKT8和OKIa)表征t细胞CLL(8例)的血液和骨髓淋巴细胞。t细胞CLL的诊断主要是由于每个患者的大部分血液淋巴细胞形成E-SRBC。其他标记物- eac, EA γ和SmIg-显示出与E-SRBC不同的关联模式。这些发现共同描述了这些患者的4种不同表型:(a) E+(3例)，(b) E+， EAC+(1例)，(c) E+， EA γ +(2例)，(d) E+， SmIg+(2例)。同样，在单克隆抗体的帮助下，划分了4个不同的组。辅助性T细胞(3例)和抑制性T细胞(1例)CLL分别以辅助性T细胞和抑制性T细胞为主。混合型t细胞CLL(1例)由两种亚群的比例相等，其余3例患者，其中一种或另一种亚群过多，同时携带Ia抗原淋巴细胞的比例相当大，形成不确定细胞型CLL。
{"title":"Heterogeneity of T-lymphocyte chronic lymphatic leukaemia (CLL). Study with conventional surface markers and monoclonal antibodies.","authors":"A. Singh, P. Lewis, G. Wetherley‐Mein","doi":"10.1111/J.1600-0609.1984.TB02178.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1984.TB02178.X","url":null,"abstract":"Lymphocyte surface markers (E-SRBC, EAC, EA gamma and SmIg) and monoclonal antibodies (OKT3, OKT4, OKT8 and OKIa) were used to characterise the blood and bone marrow lymphocytes of T-cell CLL (8 patients). The diagnosis of T-cell CLL was made primarily as the majority of blood lymphocytes formed E-SRBC in each patient. Other markers-EAC, EA gamma and SmIg--showed different patterns of association with E-SRBC. These findings considered together described 4 different phenotypes amongst these patients: (a) E+ (3 patients), (b) E+, EAC+ (1 patient), (c) E+, EA gamma + (2 patients), and (d) E+, SmIg+ (2 patients). Similarly, 4 different groups were defined with the help of monoclonal antibodies. Helper T-cell (3 patients) and suppressor T-cell (1 patient) CLL showed predominantly helper T- and suppressor T-lymphocytes respectively. Mixed T-cell CLL (1 patient) comprised an equal proportion of both subpopulations, while the remaining 3 patients, with excess of one or other subpopulations along with a considerable proportion of Ia antigen-bearing lymphocytes, formed the indeterminate cell type CLL.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"50 1","pages":"195-206"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76158292","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1981.TB01408.X
N. Ciavarella, S. Coccheri, P. Mannucci, M. Canciani, G. Mariani, P. Mori, M. Orlando, L. Tentori, O. Ponari
An internationally standardized preparation and 10 commercial kits widely used to perform the activated partial thromboplastin time (APTT) were compared in 4 laboratories for the purpose of assessing their ability to detect mild deficiencies of factor VIII activity. The participating laboratories were asked to carry out with each APTT reagent quadruplicate readings of 3 coded lyophilized plasmas containing varying levels of factor VIII (109, 26 and 17 U/dl respectively). An analysis of variance of clotting times showed significant differences between reagents and laboratories. All the reagents detected the abnormality of the plasma containing 17 U/dl, whereas a number of failures were found when the plasma with 26 U/dl was tested. When analysis of variance was carried out on ratios of factor-VIII deficient to normal plasma clotting times, the results showed less difference between laboratories and reagents. Clotting times of plasma with normal factor VIII level (109 U/dl) usually fell within the normal range indicated by manufacturers of the commercial reagents.
{"title":"Activated partial thromboplastin time. A multicenter evaluation of 11 reagents in the screening of mild haemophilia A","authors":"N. Ciavarella, S. Coccheri, P. Mannucci, M. Canciani, G. Mariani, P. Mori, M. Orlando, L. Tentori, O. Ponari","doi":"10.1111/J.1600-0609.1981.TB01408.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1981.TB01408.X","url":null,"abstract":"An internationally standardized preparation and 10 commercial kits widely used to perform the activated partial thromboplastin time (APTT) were compared in 4 laboratories for the purpose of assessing their ability to detect mild deficiencies of factor VIII activity. The participating laboratories were asked to carry out with each APTT reagent quadruplicate readings of 3 coded lyophilized plasmas containing varying levels of factor VIII (109, 26 and 17 U/dl respectively). An analysis of variance of clotting times showed significant differences between reagents and laboratories. All the reagents detected the abnormality of the plasma containing 17 U/dl, whereas a number of failures were found when the plasma with 26 U/dl was tested. When analysis of variance was carried out on ratios of factor-VIII deficient to normal plasma clotting times, the results showed less difference between laboratories and reagents. Clotting times of plasma with normal factor VIII level (109 U/dl) usually fell within the normal range indicated by manufacturers of the commercial reagents.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"75 1","pages":"308-317"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76173380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1981.TB01655.X
L. Vilén, K. Fredén, J. Kutti
{"title":"Comments to the above letter","authors":"L. Vilén, K. Fredén, J. Kutti","doi":"10.1111/J.1600-0609.1981.TB01655.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1981.TB01655.X","url":null,"abstract":"","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"45 1","pages":"253-253"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91431852","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1968.TB01712.X
H. Olesen, B. Hom, M. Schwartz
{"title":"Antibody to Transcobalamin II in Patients Treated with Long Acting Vitamin B12 Preparations","authors":"H. Olesen, B. Hom, M. Schwartz","doi":"10.1111/J.1600-0609.1968.TB01712.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1968.TB01712.X","url":null,"abstract":"","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"22 1","pages":"5-16"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84838069","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1977.TB02723.X
S. Özsoylu, Necdet ALTINÖZd
The haematological and clinical data in 97 sickle-cell anaemia cases and haemato-logical findings of their parents are reported. In spite of the low Hb values of the patients, they tolerated their anaemia and very rarely required blood transfusions. The Hb F levels of the patients were in general higher than African origin SS anaemia patients but lower than the Shiite Saudi Arabians. However, in most of the cases the concentration of Hb F did not seem to influence the Hb concentration of the patients. Serum iron was found unexpectedly decreased in 22 % of the patients. Osmotic fragility was found decreased in 100 % of the patients and in 83.5 % of the parents. The prevalence of G-6-PD deficiency was 21.2 % in male patients and 15.6 % in the parents.
{"title":"Sickle-cell anaemia in Turkey. Evaluation of 97 cases (with parents' findings).","authors":"S. Özsoylu, Necdet ALTINÖZd","doi":"10.1111/J.1600-0609.1977.TB02723.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1977.TB02723.X","url":null,"abstract":"The haematological and clinical data in 97 sickle-cell anaemia cases and haemato-logical findings of their parents are reported. In spite of the low Hb values of the patients, they tolerated their anaemia and very rarely required blood transfusions. The Hb F levels of the patients were in general higher than African origin SS anaemia patients but lower than the Shiite Saudi Arabians. However, in most of the cases the concentration of Hb F did not seem to influence the Hb concentration of the patients. Serum iron was found unexpectedly decreased in 22 % of the patients. Osmotic fragility was found decreased in 100 % of the patients and in 83.5 % of the parents. \u0000 \u0000 \u0000 \u0000The prevalence of G-6-PD deficiency was 21.2 % in male patients and 15.6 % in the parents.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"13 1","pages":"85-92"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77851865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1982.TB00582.X
B. Hancock, I. Dunsmore, H. Swan
Pretreatment peripheral blood lymphocyte counts have been recorded in 181 consecutive untreated patients with histologically proven Hodgkin's disease and the patients followed prospectively to determine the relationship of lymphopenia to survival. Lymphocyte counts at presentation did not correspond with histology type but were lower in stage 4 disease. Survival in the 77 patients with lymphocyte counts of less than 1.5 X 10(9)/l was 49.7% which was significantly worse (P less than 0.0001) than the 74.2% survival of those with 'normal' counts. This difference was maintained even after adjustment for other acknowledged prognostic variables including sex, age, stage, symptom status, histology type, and response to treatment. The study provides evidence that the lymphocyte count can be used as a meaningful marker in the clinical staging of Hodgkin's disease.
{"title":"Lymphopenia: a bad prognostic factor in Hodgkin's disease.","authors":"B. Hancock, I. Dunsmore, H. Swan","doi":"10.1111/J.1600-0609.1982.TB00582.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1982.TB00582.X","url":null,"abstract":"Pretreatment peripheral blood lymphocyte counts have been recorded in 181 consecutive untreated patients with histologically proven Hodgkin's disease and the patients followed prospectively to determine the relationship of lymphopenia to survival. Lymphocyte counts at presentation did not correspond with histology type but were lower in stage 4 disease. Survival in the 77 patients with lymphocyte counts of less than 1.5 X 10(9)/l was 49.7% which was significantly worse (P less than 0.0001) than the 74.2% survival of those with 'normal' counts. This difference was maintained even after adjustment for other acknowledged prognostic variables including sex, age, stage, symptom status, histology type, and response to treatment. The study provides evidence that the lymphocyte count can be used as a meaningful marker in the clinical staging of Hodgkin's disease.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"1 1","pages":"193-9"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82299796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1982.TB00617.X
P. Meier, J. Fehr, U. Meyer
The activity of 5-aminolaevulinate (ALA) synthase, the first and rate-limiting of haem synthesis, was markedly reduced (13% of controls) in erythroblasts of a patient with acquired, primary sideroblastic anaemia (PASA). The reduced activity of ALA synthase could not be restored in vitro with 1 mmol/l pyridoxal-5-phosphate (PLP). Treatment of the patient with pyridoxine for several months increased the ALA synthase activity from 13% to 50% of controls in the absence and to 100% in the presence of PLP in the incubation medium. These studies suggest that both increased degradation of apo-ALA synthase and decreased affinity of ALA synthase for PLP may be involved in pyridoxine-responsive PASA.
{"title":"Pyridoxine-responsive primary acquired sideroblastic anaemia. In vitro and in vivo effects of vitamin B6 on decreased 5-aminolaevulinate synthase activity.","authors":"P. Meier, J. Fehr, U. Meyer","doi":"10.1111/J.1600-0609.1982.TB00617.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1982.TB00617.X","url":null,"abstract":"The activity of 5-aminolaevulinate (ALA) synthase, the first and rate-limiting of haem synthesis, was markedly reduced (13% of controls) in erythroblasts of a patient with acquired, primary sideroblastic anaemia (PASA). The reduced activity of ALA synthase could not be restored in vitro with 1 mmol/l pyridoxal-5-phosphate (PLP). Treatment of the patient with pyridoxine for several months increased the ALA synthase activity from 13% to 50% of controls in the absence and to 100% in the presence of PLP in the incubation medium. These studies suggest that both increased degradation of apo-ALA synthase and decreased affinity of ALA synthase for PLP may be involved in pyridoxine-responsive PASA.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"10 1","pages":"421-4"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72594706","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1976.TB01138.X
C. Sipe, A. Chanana, E. Cronkite, G. L. Gulliani, D. Joel
A rapid method for measuring volume distributions of human, calf and goat lymphocytes and their nuclei is described along with the type of quantitation these measurements can provide by computer analysis. The size distribution studies indicate the presence of two populations of lymphocytes and their nuclei irrespective of the cell source. It is suggested that proliferative fractions of various cell populations may be estimated by determining the nuclear volume distribution.
{"title":"Studies on lymphocytes XIII. Nuclear volume measurement as a rapid approach to estimate proliferative fraction.","authors":"C. Sipe, A. Chanana, E. Cronkite, G. L. Gulliani, D. Joel","doi":"10.1111/J.1600-0609.1976.TB01138.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1976.TB01138.X","url":null,"abstract":"A rapid method for measuring volume distributions of human, calf and goat lymphocytes and their nuclei is described along with the type of quantitation these measurements can provide by computer analysis. The size distribution studies indicate the presence of two populations of lymphocytes and their nuclei irrespective of the cell source. It is suggested that proliferative fractions of various cell populations may be estimated by determining the nuclear volume distribution.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"84 1","pages":"196-201"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73546385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1016/0049-3848(86)91547-1
M. López-Fernández, C. López-Berges, R. Martín, J. Nieto, F. del Río, A. López‐borrasca, J. Batlle
{"title":"Unique multimeric pattern of von Willebrand factor in a patient with a benign monoclonal gammopathy.","authors":"M. López-Fernández, C. López-Berges, R. Martín, J. Nieto, F. del Río, A. López‐borrasca, J. Batlle","doi":"10.1016/0049-3848(86)91547-1","DOIUrl":"https://doi.org/10.1016/0049-3848(86)91547-1","url":null,"abstract":"","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"3 1","pages":"302-8"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84104551","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2009-04-24DOI: 10.1111/J.1600-0609.1983.TB01517.X
C. Geisler, E. Ralfkiaer, L. Astrup, I. Christensen, E. Dickmeiss, M. Hansen, J. Larsen, J. Petersen, T. Plesner
Based on the literature and 2 patients studied, we suggest that at least 2 different clinical entities are included in the concept of T CLL: (i) a clinical variant characterized by a relatively benign course, splenomegaly without lymphadenopathy, low lymphocyte count and granulocytopenia; the proliferating lymphocyte is morphologically mature, of medium size and a cytoplasm with azurophilic granules staining positively for acid phosphatase and corresponding to parallel tubular arrays as demonstrated by electron microscopy. The cells form E-rosettes, have no surface-membrane-bound Ig, but Fc-receptors for IgG. With monoclonal antibodies, the phenotype is OKT3+, OKT4- and OKT8+, theoretically corresponding to the suppressor/cytotoxic T lymphocyte subset, but functionally the cells demonstrate killer cell (responsible for ADCC), but not natural or suppressor cell activity. (ii) another clinical variant with an aggressive course, massive hepato-splenomegaly, lymph node enlargement and very high lymphocyte counts; the lymphocytes are small without cytoplasmic granules; their immunological and functional characteristics have not been determined, but morphologically the cells correspond to the T helper/inducer lymphocyte subset. Thus, involvement of different T lymphocyte subsets may be the reason for the clinical variation in T CLL.
{"title":"Chronic lymphocytic leukaemia of T cell origin. Clinical variation possibly due to involvement of different T lymphocyte subpopulations.","authors":"C. Geisler, E. Ralfkiaer, L. Astrup, I. Christensen, E. Dickmeiss, M. Hansen, J. Larsen, J. Petersen, T. Plesner","doi":"10.1111/J.1600-0609.1983.TB01517.X","DOIUrl":"https://doi.org/10.1111/J.1600-0609.1983.TB01517.X","url":null,"abstract":"Based on the literature and 2 patients studied, we suggest that at least 2 different clinical entities are included in the concept of T CLL: (i) a clinical variant characterized by a relatively benign course, splenomegaly without lymphadenopathy, low lymphocyte count and granulocytopenia; the proliferating lymphocyte is morphologically mature, of medium size and a cytoplasm with azurophilic granules staining positively for acid phosphatase and corresponding to parallel tubular arrays as demonstrated by electron microscopy. The cells form E-rosettes, have no surface-membrane-bound Ig, but Fc-receptors for IgG. With monoclonal antibodies, the phenotype is OKT3+, OKT4- and OKT8+, theoretically corresponding to the suppressor/cytotoxic T lymphocyte subset, but functionally the cells demonstrate killer cell (responsible for ADCC), but not natural or suppressor cell activity. (ii) another clinical variant with an aggressive course, massive hepato-splenomegaly, lymph node enlargement and very high lymphocyte counts; the lymphocytes are small without cytoplasmic granules; their immunological and functional characteristics have not been determined, but morphologically the cells correspond to the T helper/inducer lymphocyte subset. Thus, involvement of different T lymphocyte subsets may be the reason for the clinical variation in T CLL.","PeriodicalId":21489,"journal":{"name":"Scandinavian journal of haematology","volume":"53 1","pages":"109-21"},"PeriodicalIF":0.0,"publicationDate":"2009-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88925823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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