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Promoting mental health in military veterans. Methodology and evaluation tools in a pilot study involving an Equine-Assisted Intervention. 促进退伍军人的心理健康。一项涉及马辅助干预的试点研究的方法学和评估工具。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-01 DOI: 10.1708/4386.43838
Barbara Collacchi, Chiara Ciacchella, Marta Borgi, Alessandra D'Onofrio, Giorgio Fanelli, Sonia Merolla, Marta Riccio, Paolo Mezzanotte, Stefania Cerino, Francesca Cirulli

Aims: Military veterans exposed to stressful or traumatic events may experience adjustment difficulties in the post-deployment period, developing a high risk of mental health-related issues. Promising complementary practices such as Equine-Assisted Therapy (EAT) are now widely used, although standardized protocols are missing. The present study aimed to develop an EAT standardized intervention.

Material and methods: A total of 16 veterans were enrolled for the study (11 veterans for the EAT group and 5 veterans for the control group). The EAT lasted 9 months and both a quantitative (State-Trait Anxiety Inventory Scale; Hamilton Depression Rating Scale; Symptom Checklist 90 Scale; Warwick Edinburgh Mental Well-Being Scale) and a qualitative evaluation (observations and guided discussions) were carried out.

Results: While standardized scales did not show significant results, the qualitative evaluation revealed improvements in participants' attitudes and behaviors (autonomy, self-confidence, sense of agency), coping strategies, management of anxiety and the gradual overcoming of interpersonal difficulties.

Discussion and conclusion: The EAT intervention was particularly appreciated with a high adherence. The empathetic relationship with the horse allowed the participants to establish positive relationships within the group. A self-awareness process emerged during guided discussions and the EAT intervention allowed veterans to rediscover a new group identity. The intervention methodology proved feasible and sustainable although with important limitations due to the low number of participants, the lack of female veterans and the distance between the equestrian rehabilitation centre and the participant's residence. The present study highlights the potential of the human-horse relationship in managing adjustment difficulties, consolidating coping strategies and developing veterans' interpersonal skills.

目的:暴露于压力或创伤事件的退伍军人可能在部署后时期经历调整困难,产生与心理健康有关的问题的高风险。尽管缺乏标准化的治疗方案,但诸如马辅助治疗(EAT)等有前景的补充疗法目前已被广泛使用。本研究旨在开发一种EAT标准化干预措施。材料与方法:共入组16名退伍军人,其中EAT组11名,对照组5名。EAT持续了9个月,同时使用了定量的(状态-特质焦虑量表;汉密尔顿抑郁评定量表;症状检查表90量表;华威爱丁堡心理健康量表)和定性评估(观察和引导讨论)进行。结果:标准化量表没有显示出显著的结果,而定性评估显示了参与者在态度和行为(自主性、自信心、代理感)、应对策略、焦虑管理和逐渐克服人际关系困难方面的改善。讨论和结论:EAT干预具有很高的依从性,尤其值得赞赏。与马的共情关系允许参与者在群体中建立积极的关系。在引导讨论中出现了自我意识过程,EAT干预使退伍军人重新发现了新的群体身份。干预方法被证明是可行和可持续的,尽管由于参与者人数少,缺乏女性退伍军人以及马术康复中心与参与者住所之间的距离而存在重要的局限性。本研究强调了人马关系在管理适应困难、巩固应对策略和发展退伍军人人际交往能力方面的潜力。
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引用次数: 0
Social Cognition and Covid-19: a rapid scoping review. 社会认知与 Covid-19:快速范围审查。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-11-01 DOI: 10.1708/4386.43836
Tommaso Barlattani, Simonetta Mantenuto, Chiara D'Amelio, Arianna Di Berardo, Francesco Capelli, Valentina Leonardi, Valentina Socci, Rodolfo Rossi, Alessandro Rossi, Francesca Pacitti

The Covid-19 pandemic has enormously impacted health, the economy, and social organisations worldwide. Public health interventions such as vaccines, protective equipment and social distancing have brought profound changes in the general and clinical population's behaviour, with different levels of adherence to social and health standards. To understand these phenomena, it is essential to know how models and theories of social behaviour influence patterns of adherence to preventive measures in the context of the pandemic. Research on social cognition can explain behavioural variables and their impact on mental well-being, creating the basis for interventions that promote adherence to prevention rules. This PRISMA-ScR (Preferred Reporting Items for Systematic Reviews and Meta-Analyses extension for Scoping Reviews) rapid review aims to identify and analyse current evidence on the pandemic's impact on social cognition components. First, we conducted a comprehensive literature review and discussed the findings narratively. Tables were constructed, and articles were sorted based on study characteristics. Finally, 14 eligible articles were identified. Our findings suggest that restrictions aimed at stemming infections and social isolation led to changes in patterns of social cognition in clinical and general populations. Among the clinical population, subjects with autism spectrum disorders and Parkinson's disease reported changes in social cognition. Among the general population, older adults and front-line workers also reported variations. Our results suggest that planning-oriented social cognition models could effectively promote adherence to preventive norms. These findings can help develop behavioural intervention models by identifying appropriate approaches for the general population and specific subgroups.

新冠肺炎大流行对全球卫生、经济和社会组织造成了巨大影响。疫苗、防护设备和保持社会距离等公共卫生干预措施使一般人群和临床人群的行为发生了深刻变化,对社会和卫生标准的遵守程度也有所不同。要了解这些现象,就必须了解在大流行病背景下,社会行为模型和理论如何影响遵守预防措施的模式。对社会认知的研究可以解释行为变量及其对心理健康的影响,为促进遵守预防规则的干预创造基础。这项PRISMA-ScR(系统评价和荟萃分析扩展范围评价的首选报告项目)快速审查旨在确定和分析有关大流行对社会认知成分影响的现有证据。首先,我们进行了全面的文献综述,并对研究结果进行了叙述性讨论。构建表格,并根据研究特征对文章进行排序。最终确定了14篇符合条件的文章。我们的研究结果表明,旨在遏制感染和社会隔离的限制导致临床和一般人群的社会认知模式发生变化。在临床人群中,患有自闭症谱系障碍和帕金森病的受试者报告了社会认知的变化。在普通人群中,老年人和一线工作人员也报告了差异。我们的研究结果表明,以计划为导向的社会认知模型可以有效地促进对预防规范的遵守。这些发现可以通过确定适用于一般人群和特定亚群体的适当方法,帮助开发行为干预模型。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders. [意大利胎儿酒精中毒谱系障碍诊断和治疗指南]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43508
Mauro Ceccanti, Giovanna Coriale, Daniela Fiorentino, Angela Iannitelli, Luigi Tarani, Marco Fiore

Drinking alcohol during pregnancy can cause congenital disabilities. J. Roquette, P. Lemoine and K.L. Jones were the first to describe these effects. In 1973, Jones and Smith coined the term Fetal Alcohol Syndrome to describe children with facial anomalies, poor growth, and learning difficulties. The caution against drinking during pregnancy has existed for centuries, including in The Bible (Judges 13:3-4). Maternal alcohol consumption is linked to congenital disabilities. To ensure safety, it is advised to abstain from alcohol during pregnancy. Fetal Alcohol Spectrum Disorder (FASD) was observed in paintings from the mid-19th century when artists began depicting moments and characters from everyday life. In 2005-2006, Italy conducted a groundbreaking study on FASD, the first in Europe. The study resulted in valuable research on FASD, contributing to prevention efforts. Unfortunately, diagnosing FASD remains a challenge in Italy. Early diagnosis and treatment are critical, and increasing the number of authorized centers to diagnose FASD is necessary to improve care. Educating ourselves about FASD is the key to creating a world where affected children receive the care they need. These guidelines include nine works dealing with all FASD aspects such as prevention, the effects on cognition, the epidemiology, the diagnostic criteria, the clinical aspects, the general effects on the body, the available treatments and the methods of detecting alcohol abuse in pregnant women.

摘要孕期饮酒可导致先天性残疾。J. Roquette、P. Lemoine 和 K.L. Jones 最早描述了这些影响。1973 年,琼斯和史密斯创造了 "胎儿酒精综合征 "一词,用来描述面部畸形、发育不良和学习困难的儿童。几个世纪以来,人们一直对孕期饮酒持谨慎态度,《圣经》中也有相关记载(《士师记》13:3-4)。孕妇饮酒会导致先天性残疾。为确保安全,建议孕期和哺乳期禁酒。胎儿酒精紊乱症(FASD)的证据还可以在 19 世纪中期的绘画作品中观察到,当时的艺术家开始描绘日常生活中的瞬间和人物。2005-2006 年,意大利开展了一项关于 FASD 的创新研究,这在欧洲尚属首次。该研究对 FASD 进行了有价值的研究,为预防工作做出了贡献。遗憾的是,在意大利,诊断 FASD 仍然是一项挑战。早期诊断和治疗至关重要,为了改善护理,需要增加授权诊断 FASD 的中心数量。本指南由九篇论文组成,涵盖了 FASD 的各个方面,如预防、对认知的影响、流行病学、诊断标准、临床方面、对身体的一般影响、现有治疗方法以及检测孕期酗酒的方法。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: multimodal approaches of treatment and intervention. [意大利胎儿酒精谱系障碍诊断和治疗指南:多模式治疗和干预方法]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43513
Giovanna Coriale, Arianna Barzacchi, Daniela Fiorentino, Luigi Tarani, Marisa Patrizia Messina, Maria Concetta Scamporrino, Giuseppe Ducci, Stefano Cavallari, Marco Fiore, Antonella Cavalieri, Mauro Ceccanti

Fetal Alcohol Spectrum Disorders (FASD) are pervasive disorders that impact various domains of functioning, including self-esteem, familiar and peer relationships, and academic success. The high rate of comorbidity may contribute to delayed diagnosis and treatment. Early diagnosis and intervention that aim at primary symptoms may prevent secondary disabilities and improve the outcomes. No intervention emerged as maximally effective across all symptoms and domains. Consequently, the complex pathophysiology of FASD emphasizes the need for individualized assessment and treatment by using a multimodal approach to intervention.

摘要。胎儿酒精谱系障碍(FASD)是一种普遍存在的疾病,会影响各方面的功能,包括自尊、家庭和同伴关系以及学业成就。合并症的高发率可能会导致诊断和治疗的延迟。早期诊断和针对主要症状的干预可以预防继发性残疾并改善治疗效果。目前还没有一种干预措施能在所有症状和领域发挥最大功效。因此,FASD 复杂的病理生理学强调了采用多模式干预方法进行个性化评估和治疗的必要性。领养、产前酒精暴露、干预、胎儿酒精谱系障碍、胎儿酒精综合征、治疗。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: epidemiology [意大利胎儿酒精谱系障碍诊断和治疗指南:流行病学]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43516
Mauro Ceccanti, Giovanna Coriale, Daniela Fiorentino, Luigi Tarani, Marisa Patrizia Messina, Mario Vitali, Marco Fiore, Philip A May

Fetal alcohol spectrum disorders (FASD) are a significant global challenge characterized by complex diagnosis and research. The diagnostic process is complicated due to overlapping symptoms with other conditions, as well as factors such as maternal nutrition, socioeconomic status, and mental health, which can affect the severity of FASD traits differently in individuals. Risky drinking behaviors are prevalent in young adults, especially those aged 20-24, which coincides with high rates of unplanned pregnancies, increasing the risk of FASD. Specific subpopulations, such as children in care facilities and specialized clinical settings, face higher FASD prevalence. Preventing alcohol consumption during pregnancy is crucial for maternal and fetal well-being. Yet approximately 10% of women worldwide continue to drink during pregnancy, with notably high rates in the European Region. Young adults, especially in countries like Italy, continue to consume alcohol despite legal restrictions, mirroring the drinking patterns of men and raising concerns for fetal health and development. Research findings regarding alcohol’s risks during pregnancy vary, emphasizing the need for increased education on this issue. Ethylglucuronide (EtG) is a reliable biomarker for monitoring alcohol intake during pregnancy, suggesting regular urine examinations throughout each trimester. Proactive education campaigns, particularly in educational institutions, and establishing early diagnosis centers are recommended to address FASD effectively.

摘要胎儿酒精谱系障碍(FASD)是一项重大的全球性挑战,其特点是诊断和研究复杂。由于症状与其他疾病重叠,加上母亲的营养状况、社会经济地位和心理健康等因素,诊断过程十分复杂,这些因素可能会对不同个体的 FASD 特征的严重程度产生不同的影响。与饮酒有关的危险行为在青壮年中十分普遍,尤其是在 20-24 岁的人群中,这与意外怀孕率高的情况相吻合,从而增加了罹患 FASD 的风险。特定的亚人群,如护理机构和特殊临床环境中的儿童,面临着更高的 FASD 患病率。防止孕期饮酒对孕产妇和胎儿的健康至关重要。然而,全球约有 10%的妇女在怀孕期间继续饮酒,欧洲地区的比例更高。特别是在意大利等国,尽管有法律限制,但年轻成年人仍在继续饮酒,这与男性的饮酒模式如出一辙,引起了人们对健康和胎儿发育的担忧。有关怀孕期间饮酒风险的研究结果各不相同,这突出表明有必要就这一主题开展更多教育。乙基葡萄糖醛酸(EtG)是监测孕期酒精摄入量的可靠生物标志物,建议在每个孕期定期进行尿检。建议开展积极主动的教育活动,特别是在教育机构,并建立早期检测中心,以有效解决 FASD 问题。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: detecting alcohol drinking during pregnancy. [意大利胎儿酒精谱系障碍诊断和治疗指南:孕期饮酒检测]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43514
Giampiero Ferraguti, Francesca Fanfarillo, Simona Nicotera, Sergio Terracina, Clementina Moschella, Alessandro Mattia, Maria Chiara David, Simona Pichini, Giovanna Coriale, Daniela Fiorentino, Mauro Ceccanti, Maria Grazia Piccioni, Luigi Tarani, Marco Fiore

Fetal Alcohol Spectrum Disorders (FASD) is an encompassing term used to describe a range of afflictions brought about by the consumption of alcohol during gestation. The detrimental effects primarily manifest in the central nervous system, growth, and distinctive facial features. Given that there are no known treatments for FASD, the meticulous screening for this condition in the earliest stages of pregnancy bears immense significance, ensuring the avoidance of the grievous consequences stemming from exposure to alcohol in utero. Screening measures for FASD encompass the assessment of alcohol biomarkers such as Phosphatidylethanol (PEth) in the maternal bloodstream, Fatty Acid Ethyl Esters (FAEEs) in the meconium, and Ethyl Glucuronide (EtG) in the meconium, maternal urine and hair. In particular, urinary EtG is highly sensitive and could be routinely used in pregnant women for detecting also occasional drinking. Questionnaire evaluations including AUDIT-C, T-ACE, and TWEAK, alongside a detailed Food Diary method to identify alcohol misuse and high-risk pregnancies, are also available. However, these questionnaires might provide an inadequate reflection of alcohol consumption in women due to their inclination to dissemble to comply with prevailing sociocultural expectations. Hence, this comprehensive review advocates for the indispensable integration of alcohol biomarkers detection in the course of pregnancy monitoring, as it constitutes a valuable tool for facilitating FASD screening.

摘要。胎儿酒精紊乱症(FASD)是一个包罗万象的术语,用于描述妊娠期饮酒导致的一系列疾病。其危害主要表现在中枢神经系统、生长发育和独特的面部特征上。由于目前尚无治疗 FASD 的方法,因此在孕早期对这种疾病进行细致的筛查意义重大,可有效限制子宫内酒精暴露造成的严重后果。FASD 筛查措施包括评估酒精生物标记物,如母体血液中的磷脂酰乙醇(PEth)、胎粪中的脂肪酸乙酯(FAEE)以及胎粪、母体尿液和毛发中的乙基葡萄糖醛酸(EtG)。尤其是尿液中的 EtG 灵敏度很高,可用于常规检测孕妇是否偶尔摄入。此外,还可通过 AUDIT-C、T-ACE 和 TWEAK 等问卷进行评估,并通过食物日记来识别酗酒和高危妊娠。然而,这些问卷可能无法充分反映妇女的饮酒情况,因为她们倾向于撒谎以迎合普遍的社会文化期望。因此,这项工作强调了在妊娠监测期间进行酒精生物标志物检测是不可或缺的,是促进早期发现可能的 FASD 的宝贵工具。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: international diagnostic criteria - differences and similarities. [意大利胎儿酒精谱系障碍诊断和治疗指南:国际诊断标准:异同]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43511
Ginevra Micangeli, Roberto Paparella, Michela Menghi, Mauro Ceccanti, Giovanna Coriale, Daniela Fiorentino, Harold Eugene Hoyme, Marco Fiore, Giampiero Ferraguti, Giovanni Corsello, Simona Pichini, Luigi Tarani

The umbrella term Fetal Alcohol Spectrum Disorders (FASD) brings together under its definition a heterogeneous continuum of disabilities linked by a common etiology and pathogenesis: exposure to alcohol during intrauterine life. Despite extensive research, definitive toxic thresholds remain elusive, underscoring the recommendation for complete alcohol abstinence during pregnancy and lactation. FASD poses diagnostic challenges due to its varied presentations and heterogeneous phenotype. Consequently, no singular diagnostic guideline exists, with multiple expert-driven diagnostic systems globally available. This review aims to synthesize recent and notable guidelines facilitating FASD diagnosis. While efforts were made to include the latest diagnostic systems, determining which scheme is best applied to each individual patient population necessitates clinician discretion. In Italy, the guidelines proposed by Hoyme, revised in 2016, are commonly utilized, yet comparative analysis among guidelines offers valuable insights into their historical context and diagnostic utility. Our discussion explores both similarities and discrepancies among systems for diagnosing FASD, shedding light on their evolution and practical application. The objective of our work was to compare in a practical and precise manner the various existing guidelines used globally regarding the diagnosis of FAS. Our review therefore proposes the diagnostic criteria used by the various working groups and compares them, trying to create a practical comparison between the various guidelines, identifying differences and similarities.

摘要。胎儿酒精中毒谱系障碍(FASD)的定义汇集了各种不同类型的疾病,它们有一个共同的发病机制:胎儿接触酒精。尽管进行了大量研究,但毒性阈值仍未确定,因此不得不建议在孕期和哺乳期完全禁酒。FASD 的临床表现多种多样,表型也不尽相同,这也给诊断带来了挑战。因此,目前并没有单一的诊断指南,而是根据起草者的专业知识编写了多份全球通用的指南。本综述旨在总结最广泛使用的 FASD 诊断指南。尽管我们已经做了大量的工作来综合最新的指南,但仍然没有一份指南能够涵盖以前指南中的所有标准,因此诊断医生在诊断时仍然有一定的自由裁量权。在意大利,Hoyme 等人提出的指南(2016 年修订)被普遍使用,但指南之间的比较分析为了解其历史背景和诊断效用提供了宝贵的见解,为进一步提出总结所有指南的建议奠定了基础。本文探讨了现有各种指南之间的异同,揭示了它们的演变和实际应用。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: prevention and health promotion. [意大利胎儿酒精谱系障碍诊断和治疗指南:预防和促进健康]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43515
Daniela Fiorentino, Giovanna Coriale, Luigi Tarani, Marco Fiore, Mario Vitali, Marisa Patrizia Messina, Mauro Ceccanti

Alcohol consumption during pregnancy poses significant risks to maternal and fetal health, contributing to a range of adverse outcomes collectively known as Fetal Alcohol Spectrum Disorders (FASD). This article reviews evidence-based preventive strategies aimed at mitigating the detrimental effects of prenatal alcohol exposure. Drawing upon literature from various disciplines, interventions are categorized according to their level of prevention: universal, selective, and indicated. Training of personnel and availability of official guidelines are a pre-requisite for effective prevention. Universal prevention strategies include public health campaigns, educational initiatives, and policy interventions aimed at raising awareness about the risks of prenatal alcohol exposure and promoting abstinence during pregnancy. Integrating alcohol screening and brief intervention protocols into routine prenatal care settings can help identify and support women who may be at risk of alcohol use during pregnancy. Consequently, selective and indicated interventions, identifying drinking women, may provide targeted support to pregnant women at risk. Indicated prevention interventions also encompass treatment and rehabilitation strategies for women with a known alcohol abuse problem or who have already had alcohol-exposed pregnancies. Finally, ethical issues related to the stigma associated with alcohol consumption during pregnancy are highlighted, to be considered for an effective mother and child health promotion.

摘要孕期饮酒对孕产妇和胎儿的健康构成重大风险,会导致一系列不良后果,统称为胎儿酒精紊乱症(FASD)。本文分析了旨在减轻产前酒精暴露有害影响的循证预防策略。根据不同学科的文献,干预措施按其预防程度分为:普遍预防、选择性预防和指示性预防。普遍预防方法包括公共卫生运动、教育倡议和政策干预,旨在提高对产前酒精暴露风险的认识,促进孕期戒酒。将酒精筛查和简短干预方案纳入常规产前保健,有助于识别和支持孕期有饮酒风险的妇女。这些选择性和指示性干预通过识别孕期饮酒的妇女,能够为有风险的妇女提供有针对性的支持。有针对性的预防策略还包括针对已知有酗酒问题或已经有过酗酒妊娠经历的妇女的个性化治疗和康复策略。最后,为有效促进妇女和儿童的健康,还强调了与孕期饮酒相关的道德问题。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: clinical hallmarks. [意大利胎儿酒精谱系障碍诊断和治疗指南:临床特征]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43510
Michela Menghi, Ginevra Micangeli, Roberto Paparella, Mauro Ceccanti, Giovanna Coriale, Giampiero Ferraguti, Marco Fiore, Daniela Fiorentino, Maria Grazia Piccioni, Luigi Tarani

Fetal Alcohol Spectrum Disorders (FASD) are a condition that arises when a person is exposed to alcohol during pregnancy. The main clinical manifestations include craniofacial anomalies, growth retardation, birth defects and change in brain structure and function. These alterations can result in deficits across various domains such as cognition, executive function, memory, vision, hearing, motor skills, behavior, and social adaptation. The effects of alcohol extend beyond the brain, affecting other systems including sensory organs, heart, and kidneys. Given that diagnosing FASD involves excluding other conditions, it is crucial for physicians to be familiar with its main characteristics to facilitate early identification and implement appropriate health strategies for the patient. Moreover, there is a pressing need for primary prevention strategies centered around raising awareness about the risks associated with alcohol consumption during pregnancy. The articles for this report aimed to analyze and evaluate studies focusing on the clinical features observed in FASD children were sourced from online databases such as Medline, Medline Complete and PubMed, covering literature published between 1981 and 2024, written in English, using search terms such as fetal alcohol spectrum disorders, fetal alcohol syndrome, prenatal alcohol exposure, and alcohol-related birth defects. The evidence gathered underscores that prenatal alcohol exposure primarily affects the brain and its functions, resulting in severe impacts. Furthermore, abnormalities in other vital organs such as the sensory, cardiovascular, and renal systems are frequently observed.

摘要胎儿酒精中毒谱系障碍(FASD)是一种在怀孕期间接触到酒精的疾病。主要临床表现包括颅面畸形、发育迟缓、先天缺陷以及大脑结构和功能的改变。这些改变可导致认知能力、执行功能、记忆力、视力、听力、运动技能、行为和社会适应方面的缺陷。酒精的影响不仅限于大脑,还会影响其他系统,包括感觉器官、心脏和肾脏。由于 FASD 的诊断意味着要排除其他疾病,因此医生必须熟悉其主要特征,以便及早识别并为患者实施适当的保健策略。此外,迫切需要制定以提高对孕期饮酒相关风险的认识为重点的初级预防策略。本综述摘录的文章旨在分析和评估有关胎儿酒精中毒综合症患儿临床特征的研究;文章从 Medline、Medline Complete 和 PubMed 等在线数据库中检索,涵盖 1981 年至 2024 年间发表的英文文献,检索词包括胎儿酒精中毒谱系障碍、胎儿酒精中毒综合症、产前酒精暴露和酒精相关出生缺陷。数据指出,产前接触酒精主要影响大脑及其功能,造成严重影响。此外,其他重要器官如感觉、心血管和肾脏系统也经常出现异常。
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引用次数: 0
Italian Guidelines for the diagnosis and treatment of Fetal Alcohol Spectrum Disorders: cognitive and behavioral deficits. [意大利胎儿酒精谱系障碍诊断和治疗指南:认知和行为缺陷]。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-09-01 DOI: 10.1708/4360.43517
Giovanna Coriale, Arianna Barzacchi, Mauro Ceccanti, Luigi Tarani, Simona Gencarelli, Maria Giuseppa Elmo, Martino Mistretta, Marisa Patrizia Messina, Simone De Persis, Marco Fiore, Daniela Fiorentino

Fetal alcohol spectrum disorders (FASDs) refer to a group of clinical conditions that occur in a person exposed to alcohol before birth. Neuroimaging shows abnormalities in brain structure, cortical development, white matter microstructure, and functional connectivity in individuals with FASD. These abnormalities modify the normal developmental trajectories resulting in deficits in cognition and behavior across several domains, including general intelligence, memory, language, attention, learning, visuospatial abilities, executive functioning, fine and gross motor skills, and social and adaptive functioning. This paper provides a review of the cognitive and behavioral outcomes of prenatal alcohol exposure. Updates data on FASD-specific neurobehavioral profile and its potential as a diagnostic tool will then be presented.

摘要。胎儿酒精谱系障碍(FASD)是指在怀孕期间接触酒精而导致的一组临床症状。神经影像学研究证明,胎儿酒精紊乱症患者的大脑结构、皮质发育、白质微结构和功能连接均存在异常。这些异常改变了正常的发育轨迹,导致了影响多个领域认知和行为的缺陷,包括一般智力、记忆、语言、注意力、学习、视觉空间技能、执行功能、精细和粗大运动技能以及社交和适应功能。本文综述了产前酒精暴露对认知和行为的影响。然后将介绍有关 FASD 具体神经行为特征的最新数据及其作为诊断工具的潜力。
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引用次数: 0
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