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Risk factors for attempted suicide in non-psychotic patients with suicidal ideation. 有自杀意念的非精神病患者企图自杀的风险因素。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-05-01 DOI: 10.1708/4288.42697
Mikhail Zinchuk, Alla Avedisova, Ettore Beghi, Massimiliano Beghi, Elisa Bianchi, Cesare Maria Cornaggia, Daniele Piscitelli, Lina Urh, Chiara Crotti, Alexander Yakovlev, Alla Guekht

Objective: In Eastern European countries, suicide rate are among the highest in the world and suicide attempts are among the most important risk factors. The aim of this study is to identify factors associated with suicide attempt (SA) in non-psychotic patients with suicidal ideation (SI).

Methods: Among 6204 consecutive adult patients (residents of Moscow) with non-psychotic mental disorders (NPMD), 361 individuals aged 18-77 years (median 24 years) were enrolled in the study after screening for lifetime SI with the Self-Injurious Thoughts and Behaviors Interview (SITBI). All participants were assessed for sociodemographic variables, psychiatric diagnosis, family history of mental disorders, history of abuse, sexual behavior, psychiatric treatments, suicide plan, SA, and nonsuicidal self-injury (NSSI). Results of multivariable analyses (MV) are presented as odds ratios (OR) with 95% confidence intervals (CI).

Results: 166 patients (46%) reported lifetime SA. In MV, variables associated with SA included smoking (OR 2.1; 95% CI 1.2-3.7), having made a suicide plan (OR 3.4; 95% CI 2.0-5.7), and scars covered by tattoos (OR 5.2; 95% CI 1.5-17.9). History of law violation (OR 2.0; 95% 1.0-4.2) was of borderline significance.

Conclusions: Transition from SI to SA in patients with NPMD was associated with smoking, suicide planning, history of law violation and presence of tattoos covering scars.

目的:在东欧国家,自杀率位居世界前列,自杀未遂是最重要的风险因素之一。本研究旨在确定有自杀意念(SI)的非精神病患者中与自杀未遂(SA)相关的因素:在 6204 名连续的非精神病性精神障碍(NPMD)成年患者(莫斯科居民)中,有 361 名年龄在 18-77 岁之间(中位数为 24 岁)的患者在通过自伤想法和行为访谈(SITBI)筛查终生 SI 后被纳入研究。对所有参与者进行了社会人口变量、精神病诊断、精神障碍家族史、虐待史、性行为、精神病治疗、自杀计划、SA 和非自杀性自伤 (NSSI) 评估。多变量分析(MV)结果以几率比(OR)和 95% 置信区间(CI)表示:166名患者(46%)报告了终生自闭症。在 MV 中,与 SA 相关的变量包括吸烟(OR 2.1;95% CI 1.2-3.7)、曾有自杀计划(OR 3.4;95% CI 2.0-5.7)和被纹身覆盖的伤疤(OR 5.2;95% CI 1.5-17.9)。违法史(OR 2.0;95% CI 1.0-4.2)的显著性处于边缘水平:结论:非母婴传播疾病患者从SI转变为SA与吸烟、自杀计划、违法史和纹身覆盖疤痕有关。
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引用次数: 0
Impact of psychological intervention on anxiety, depression, and post-traumatic stress disorder: results from a longitudinal study of hospitalized Covid-19 patients. 心理干预对焦虑、抑郁和创伤后应激障碍的影响:对住院的 Covid-19 患者进行纵向研究的结果。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-05-01 DOI: 10.1708/4288.42696
Giulia Lamiani, Federica Bonazza, Chiara Luridiana Battistini, Salvatore Iovine, Kyrie Piscopo, Francesca Bai, Elena Vegni

Objective: Hospitalization for Covid-19 has been recognized as a potentially traumatic experience. This longitudinal cohort study assessed the impact of psychological intervention for Covid-19 patients on anxiety, depression, and post-traumatic stress disorder (PTSD).

Materials and methods: Of 386 Covid-19 patients enrolled, 127 completed HADS and PCL-5 questionnaires at 2 months (T1), 6 months (T2) and 12 months (T3) after hospital discharge. Between T1 and T2, patients were offered the opportunity to receive psychological intervention: 92 did not request any psychological support (No support group), 15 received only one psychological consultation (Consultation group) and 20 received longer psychological support (Support group). Mixed ANOVAs were used to assess the psychological symptoms of the 3 Groups over Time.

Results: The No support group reported lower anxiety, depression, and PTSD than the other two groups. Anxiety and PTSD increased over time across groups. A Time x Group interaction was found for depression (F(2.124)=3.72, p<.05, pη2=.06). The Support group reported a decrease in depression from T1 (M=7.85) to T2 (M=7.05) and an increase from T2 to T3 (M=8.05), although not significant. The No support (T1 M=2.84; T3 M=4.36; p<.001) and the Consultation groups (T1 M=4.73; T3 M=6.33; p<.05) reported an increase in depression from T1 to T3.

Conclusions: Psychological interventions were appropriately allocated to patients with more severe symptoms. Most of the patients did not request psychological intervention. Long-term psychological support may have helped Covid-19 patients to contain depressive symptoms over time.

目的:Covid-19住院治疗被认为是一种潜在的创伤性经历。这项纵向队列研究评估了心理干预对 Covid-19 患者焦虑、抑郁和创伤后应激障碍(PTSD)的影响:在入组的 386 名 Covid-19 患者中,127 人分别在出院后 2 个月(T1)、6 个月(T2)和 12 个月(T3)完成了 HADS 和 PCL-5 问卷调查。在 T1 和 T2 期间,患者有机会接受心理干预:92 人未要求任何心理支持(无支持组),15 人仅接受了一次心理咨询(咨询组),20 人接受了更长时间的心理支持(支持组)。我们使用混合方差分析来评估三组随时间变化的心理症状:结果:与其他两组相比,无支持组的焦虑、抑郁和创伤后应激障碍症状较轻。各组的焦虑和创伤后应激障碍随时间推移而增加。抑郁方面存在时间 x 组间的交互作用(F(2.124)=3.72, p):心理干预适当地分配给了症状更严重的患者。大多数患者没有要求心理干预。长期的心理支持可能有助于Covid-19患者长期控制抑郁症状。
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引用次数: 0
Marital loss, gender and their association with mental health and physical health outcomes in Bosnian refugees: lesson reminder in a time of war. 波斯尼亚难民的失婚、性别及其与心理健康和身体健康结果的关系:战争时期的教训提醒。
IF 1 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-05-01 DOI: 10.1708/4288.42699
Iris Sarajlic Vukovic, Giuseppe Valeriani, Dolores Britvic, Nikolina Jovanovic, Richard Mollica

Introduction: Mental health disorders and chronic health diseases are highly prevalent and impactful consequences of distressful experiences among refugees, yet a comprehensive conceptual model encompassing biopsychosocial factors is lacking. This study aims to assess the relevance of widowhood to PTSD and major depression maintenance as well as to adverse health outcomes in a cohort of Bosnian refugees.

Methods: This longitudinal study included 526 subjects followed up for 3 years. The interviews were conducted in refugee camps in Varaždin, Croatia, in the Bosnian language. Data were collected using the Harvard Trauma Questionnaire and Hopkins Checklist-25, respectively. Physical health disorders were self-reported.

Results: Both at baseline and endpoint female gender and marital loss are associated with a statistically significant higher burden of psychological and physical health outcomes. This group showed higher rates of PTSD and major depression disorders, as high comorbidity with hypertension, cardiovascular diseases, asthma and arthritis.

Discussion: The results of the present study align with a wealth of literature studies linking marital loss to shifts in mental health and impaired physical health. A conceptual framework is provided for understanding how both mental health and physical health outcomes are highly dependent on social phenomena.

Conclusions: This investigation reinforces the hypothesis of the role of social bonds and marital support in recovery from trauma experiences. Further studies are, however, needed for a better understanding of the consequences of adverse events on trauma-exposed subjects from a holistic bio-psycho-social point of view.

导言:心理健康障碍和慢性疾病在难民中非常普遍,是痛苦经历的影响后果,但目前还缺乏一个包含生物-心理-社会因素的综合概念模型。本研究旨在评估丧偶与创伤后应激障碍和重度抑郁症的维持以及与波斯尼亚难民队列中不良健康后果的相关性:这项纵向研究包括对 526 名受试者进行为期 3 年的跟踪调查。访谈在克罗地亚瓦拉日丁的难民营中进行,使用波斯尼亚语。分别使用哈佛创伤问卷和霍普金斯检查表-25收集数据。身体健康状况为自我报告:结果:在基线和终点,女性性别和失婚都与心理和生理健康负担较高有显著的统计学关联。该群体的创伤后应激障碍和重度抑郁症发病率较高,高血压、心血管疾病、哮喘和关节炎的合并发病率也较高:本研究的结果与大量将失婚与心理健康变化和身体健康受损联系起来的文献研究结果一致。本研究为理解心理健康和身体健康结果如何高度依赖于社会现象提供了一个概念框架:这项调查加强了社会纽带和婚姻支持在创伤后恢复中的作用这一假设。然而,要从生物-心理-社会的整体角度更好地理解不良事件对受创伤者造成的后果,还需要进一步的研究。
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引用次数: 0
Role of narcissism in parental alienation phenomenon. A narrative review. 自恋在父母疏离现象中的作用。叙事回顾。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1708/4259.42357
Arianna Palmieri, Valentina Visintainer, Lisa Toffanin, Valentina Cimmino Picone

Parental Alienation Syndrome (PAS) is a term addressed to describe negative, psychopathological feelings, thinking and behaviours, including hostility and fear, exhibited by children who have been alienated from one parent by the other parent. Despite its relevance in the clinical psychology field, theoretical and empirical contributions to understanding and deepening the many facets of this concept are still few. In particular, literature aimed at disentangling the alienating parent's psychological characteristics is scarce and fragmented. Our contribution encompasses a narrative review of scientific literature since the term PAS was coined in 1987 by Gardner, to delineate narcissistic proneness in alienating parents. Namely, considering the narcissistic drift the western society is going toward, we hypothesised that narcissism has a pivotal role in parents' alienating behaviours against the alienated ones. Firstly, the elements that emerged from our literature search confirmed our theoretical hypothesis, in terms of the likely role of narcissism/narcissistic marked traits in alienating parents. In the second section, we contextualised the phenomenon in a psychodynamic/psychoanalytic theoretical framework. Finally, based on previous findings/considerations, the developmental trajectories of children with PAS have been traced. An improved theoretical knowledge of this phenomenon, also in terms of the psychopathology associated with its genesis, means to refine the diagnostic and treatment tools to prevent it.

父母疏离综合症(PAS)是一个术语,用于描述被父母中的一方疏离的子女所表现出的负面的、精神病态的情感、思维和行为,包括敌意和恐惧。尽管这一概念与临床心理学领域息息相关,但理论界和实证界对理解和深化这一概念的方方面面所做的贡献仍然很少。特别是,旨在厘清疏远父母的心理特征的文献既少又零散。我们的贡献包括对加德纳于 1987 年提出 PAS 一词以来的科学文献进行叙述性回顾,以界定疏远型父母的自恋倾向。也就是说,考虑到西方社会的自恋倾向,我们假设自恋在父母对被疏远者的疏远行为中起着关键作用。首先,我们在文献检索中发现的内容证实了我们的理论假设,即自恋/自恋标记特质在疏远父母中可能起到的作用。第二部分,我们在心理动力学/精神分析的理论框架下对这一现象进行了背景分析。最后,基于以往的研究结果/考虑,我们追溯了有 PAS 儿童的成长轨迹。提高对这一现象的理论认识,以及对与之相关的精神病理学的认识,意味着要完善诊断和治疗工具,以预防这一现象的发生。
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引用次数: 0
[On the relationship between incestuousness and destructivity: some reflection from an expert case.] [论乱伦与破坏性之间的关系:一个专家案例的思考]。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1708/4259.42362
Cristiano Barbieri, Ignazio Grattagliano

Introduction: Incestuous behaviors are often placed in family constellations that are highly dysfunctional from the perspective of communication between members and also with regard to the roles and expectations held in the family. The expert case being presented reflects these characteristics.

Methods: Beginning with an expert case of particular interest with respect to incestuousness and destructibility, the authors report considerations from a clinical criminological and forensic psychological-psychiatric point of view on the link between the two item.

Conclusions: A careful historical, anthropological, documentary reconstruction, the examination of the relational set-up of the various subjects involved, and not only the clinical and psychodiagnostic aspects, are the indispensable premises, in order to make overall sense of crimes in families of particular complexity, difficult to decipher, such as those exposed in the present scientific work.

导言乱伦行为通常发生在功能极不健全的家庭中,这不仅体现在家庭成员之间的沟通上,还体现在家庭角色和期望上。目前介绍的专家案例就反映了这些特点:方法:作者从一个对乱伦和破坏性特别感兴趣的专家案例入手,从临床犯罪学和法医心理学-精神病学的角度报告了对这两个项目之间联系的思考:要全面了解像本科学著作中揭露的那些特别复杂、难以解读的家庭犯罪,仔细的历史、人类学和文献重建,以及对各相关主体的关系设置的审查,而不仅仅是临床和心理诊断方面的审查,是不可或缺的前提。
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引用次数: 0
Mini-Z validation for burnout and stress evaluation: an observational study. 职业倦怠和压力评估的 Mini-Z 验证:一项观察研究。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1708/4259.42359
David Shaholli, Chiara Bellenzier, Corrado Colaprico, Francesca Vezza, Giovanna Carluccio, Luca Moretti, Maria Vittoria Manai, Vanessa India Barletta, Alice Mannocci, Giuseppe La Torre

Background: The Mini-Z is a questionnaire created to evaluate the levels of burnout in healthcare workers. It consists of 10 items rated using a 5-point Likert scale and one open question. It explores three outcomes (burnout, stress and satisfaction) and seven drivers of burnout (work control, work chaos, teamwork, values alignment with leadership, documentation time pressure, EMR use at home, and EMR proficiency). The aim of this study is to validate the Italian version of the Mini-Z, comparing it with the other most used scales.

Materials and methods: We recruited a sample of 120 healthcare professionals and administered all three questionnaires to each of them, after which we compared the answers and the scores of the results. A cross-sectional study among healthcare workers was conducted from May to July 2022. An online questionnaire was sent, by e-mail, to 120 healthcare workers (60.8% male, 39.2% female), aged between 18 and 60 years old (26.8% between 25 and 38 years old). They were invited to answer to an anonymous survey, consisting of three assessment instruments: Copenhagen Burnout Inventory (CBI), Maslach Burnout Inventory (MBI) and Mini-Z Inventory 2.0. The Mini-Z 2.0 is a new and easier tool to assess burnout syndrome, actually validated only in English. It was translated into Italian by reverse translation. Cronbach's Alpha coefficient, a statistical index, was used to assess its reliability. The last phase of the study compared the Mini-Z, the CBI and the MBI, by means of Pearson's coefficient, to highlight the Mini-Z's ability to be used for Burnout assessment.

Results: The analysis of the results showed that 18.3% of the interviewed healthcare professionals scored equal (2.5%) or higher (15.8%) than 40. The average percentage value was 33.35%, with a standard deviation of 6.3%. This emphasises, therefore, that this portion of employees is more or less satisfied with their working environment. The remaining portion of employees, on the other hand, 81.7%, scored below 40, emphasising an unpleasant and unjoyful working environment.

Discussion and conclusions: Burnout is very common among employees and especially among healthcare workers and a routine assessment seems to be necessary to be able to prevent the syndrome. The Italian version of the Mini-Z includes ten items, is more user-friendly and aims to assess not only Burnout subscales, as in the previous tests, but also well-being factors and has applied a rigorous approach, including forward translation, back translation and cognitive debriefing.

背景:Mini-Z 是一份用于评估医护人员职业倦怠程度的问卷。它由 10 个项目和一个开放性问题组成,项目采用 5 点李克特量表评分。它探讨了三种结果(职业倦怠、压力和满意度)和七种职业倦怠的驱动因素(工作控制、工作混乱、团队合作、与领导的价值观一致、记录时间压力、在家使用电子病历和电子病历熟练程度)。本研究的目的是验证意大利语版的 Mini-Z 量表,并将其与其他最常用的量表进行比较:我们招募了 120 名医疗保健专业人员作为样本,向他们每人发放了三份问卷,然后比较了答案和结果得分。我们于 2022 年 5 月至 7 月在医护人员中开展了一项横断面研究。我们通过电子邮件向 120 名医护人员(60.8% 为男性,39.2% 为女性)发送了在线问卷,他们的年龄在 18 岁至 60 岁之间(26.8% 在 25 岁至 38 岁之间)。他们应邀回答了由三种评估工具组成的匿名调查:哥本哈根职业倦怠量表(CBI)、马斯拉奇职业倦怠量表(MBI)和迷你 Z 量表 2.0。Mini-Z 2.0 是一种新的、更易于评估职业倦怠综合症的工具,实际上只在英语中得到了验证。它通过反向翻译被翻译成意大利语。Cronbach's Alpha 系数(一种统计指标)用于评估其可靠性。研究的最后阶段通过皮尔逊系数对 Mini-Z、CBI 和 MBI 进行了比较,以突出 Mini-Z 用于倦怠评估的能力:分析结果显示,18.3%的受访医护人员的得分等于(2.5%)或高于(15.8%)40 分。平均百分比值为 33.35%,标准偏差为 6.3%。因此,这部分员工对工作环境的满意度较高或较低。而其余 81.7% 的员工得分在 40 分以下,这说明他们的工作环境并不愉快:讨论与结论:职业倦怠在员工中非常常见,尤其是在医疗工作者中。意大利语版的 Mini-Z 包括十个项目,更加方便用户使用,其目的不仅是评估倦怠的分量表,就像以前的测试一样,还包括幸福感因素,并采用了严格的方法,包括正译、反译和认知汇报。
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引用次数: 0
Switching from paliperidone palmitate 3-monthly long-acting injection to oral aripiprazole in a pregnant woman with schizophrenia: a case report and short review. 一名精神分裂症孕妇从帕利哌酮棕榈酸酯 3 个月长效注射剂转为口服阿立哌唑:病例报告和简短回顾。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1708/4259.42361
Carolina Pinci, Emanuela Bianciardi, Irene Sferra, Giulia Castellani, Riccardo Santini, Alberto Siracusano, Cinzia Niolu

Treatment with long-acting injection (LAI) antipsychotics, such as paliperidone palmitate, has improved the quality of life in terms of symptoms and prevention of relapses in patients with schizophrenia. Although there are plenty of evidences about the efficacy and safety of paliperidone palmitate 3-monthly injection (PP3M) in adults with schizophrenia, literature appears lacking about the use of LAIs during pregnancy. We hereby describe the clinical case of a pregnant woman affected by schizophrenia (DSM-5-TR), taking pharmacological treatment of PP3M. Considering the inadequate evidence regarding the use of PP3M in pregnancy in agreement with the patient, we switched PP3M to an oral therapy with aripiprazole. The switch to oral aripiprazole allowed the patient to improve her sense of autonomy and strengthen the therapeutic relationship. To our knowledge, this is the first case report monitoring an entire pregnancy of a women affected by schizophrenia in treatment with PP3M injection and oral aripiprazole. No obstetrical or fetal complications were reported. As the research in this field is very demanding, it would be precipitous to derive final conclusions from the current case report, but we hope to build a growing number of data that would allow us to make more appropriate and safe therapeutic choices in such a vulnerable phase as the peripartum.

使用帕利哌酮棕榈酸酯等长效注射型(LAI)抗精神病药物治疗可改善精神分裂症患者的症状并预防复发,从而提高其生活质量。尽管有大量证据表明帕利哌酮棕榈酸酯 3 个月注射液(PP3M)对成人精神分裂症患者具有疗效和安全性,但似乎缺乏有关妊娠期使用 LAIs 的文献。我们在此描述一名患有精神分裂症(DSM-5-TR)并接受 PP3M 药物治疗的孕妇的临床病例。考虑到有关妊娠期使用 PP3M 的证据不足,在征得患者同意后,我们将 PP3M 改为口服阿立哌唑治疗。改用阿立哌唑口服治疗后,患者的自主感得到了改善,治疗关系也得到了加强。据我们所知,这是第一例监测受精神分裂症影响的妇女在接受 PP3M 注射和阿立哌唑口服治疗后整个孕期的病例报告。没有产科或胎儿并发症的报道。由于该领域的研究工作十分繁重,因此从目前的病例报告中得出最终结论未免过于草率,但我们希望能够积累越来越多的数据,从而使我们能够在围产期这样一个脆弱的阶段做出更适当、更安全的治疗选择。
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引用次数: 0
Perinatal mental health and Covid-19-related distress: the role of personality traits. 围产期心理健康与 Covid-19 相关困扰:人格特质的作用。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1708/4259.42360
Melania Martucci, Matteo Panfili, Nicoletta Giacchetti, Francesco Saverio Bersani, Paola Ciolli, Alessandra Forte, Carla Sogos, Franca Aceti

Background: Perinatal mental health is a topic of growing interest, that could affect mothers in a period of high vulnerability, and the impact of coronavirus disease 2019 (Covid-19) pandemic is an important factor to consider in this field. The aim of our study is to study the correlations between five dimensions of personality and subjective Covid-19-related distress in a sample of women in the perinatal period.

Methods: The study included 114 Italian women in the perinatal period. Subjects were asked to complete the Big Five Inventory (BIG-5) and a version of the Impact of Event Scale - Revised (IES-R) anchored to Covid-19-related distress.

Results: When the BIG-5 personality traits and several confounding variables were included in a regression model with IES-R total score as criterion, neuroticism subscale of BIG-5 inventory was the only variable independently associated with higher IES-R total score (p<0.001).

Conclusion: Our study highlights the importance of considering the personality vulnerability factors that can worsen psychopathological symptoms of women in the perinatal period, especially in periods of high psychological stress.

背景:围产期心理健康是一个日益受到关注的话题,它可能会影响到处于高度脆弱期的母亲,而冠状病毒病2019(Covid-19)大流行的影响是这一领域需要考虑的一个重要因素。我们的研究旨在研究围产期妇女样本中人格的五个维度与主观Covid-19相关困扰之间的相关性:研究对象包括 114 名意大利围产期妇女。受试者被要求完成大五人格量表(BIG-5)和事件影响量表-修订版(IES-R),该量表锚定了与 Covid-19 相关的困扰:结果:在以 IES-R 总分为标准的回归模型中纳入 BIG-5 人格特质和几个混杂变量时,BIG-5 量表中的神经质分量表是唯一一个与较高的 IES-R 总分独立相关的变量(p):我们的研究强调了考虑人格脆弱性因素的重要性,这些因素可能会加重围产期妇女的精神病理症状,尤其是在高心理压力时期。
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引用次数: 0
Delay in the fine-tuning of locomotion in infants with meconium positive to biomarkers of alcohol exposure: a pilot study. 对酒精暴露生物标志物呈阳性胎粪的婴儿运动微调延迟:一项试点研究。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-03-01 DOI: 10.1708/4259.42358
Giovanna Coriale, Mauro Ceccanti, Marco Fiore, Francesca Tarani, Ginevra Micangeli, Michela Menghi, Adele Minutillo, Paolo Berretta, Giampiero Ferraguti, Angela Iannitelli, Giovanni Parlapiano, Roberto Paparella, Marisa Patrizia Messina, Mario Vitali, Daniela Fiorentino, Simona Pichini, Luigi Tarani

Introduction: Prenatal alcohol exposure causes a variety of impairments to the fetus called Fetal Alcohol Spectrum Disorders (FASD). Since it is very difficult to identify women that consume alcohol during pregnancy, different methods have been studied to evaluate alcohol exposure. Ethyl Glucuronide (EtG) and Fatty Acid Ethyl Esters (FAEEs) are commonly used to measure alcohol consumption in individuals at-risk for alcohol abuse, including pregnant women.

Materials and methods: We conducted a study of two cohorts of 1.5 year-old infants (of mothers without a history of alcohol abuse) with or without meconium samples positive to both EtG and FAEEs and we evaluated their cognitive-behavioral development by the Griffiths Mental Developmental Scale (GMDS) method. Our protocol included 8 infants with meconium positive to alcohol metabolites (EtG and FAEEs) and 7 with meconium negative to alcohol metabolites.

Results: None of the 8 alcohol metabolites positive meconium infants exhibited distinctive facial features and growth retardation of severe FASD, showing that other factors may contribute to the FASD onset but elevations in EtG and FAEEs in the meconium were significantly associated with disrupted neurodevelopment and adaptive functions within the first year and a half of life. Indeed, we found out that infants with meconium positive for both EtG and FAEEs, although without displaying any FASD morphological features, had a delay in the fine regulation of their own locomotory capabilities.

Conclusions: Further analyses and larger studies are needed to estimate the right link between prenatal alcohol exposure and the different range of disorders connected but this study provides an additional step in the field of FASD in order to suggest early treatments for at-risk newborns and infants.

导言:产前接触酒精会对胎儿造成各种损伤,被称为胎儿酒精紊乱症(FASD)。由于很难识别怀孕期间饮酒的妇女,因此人们研究了不同的方法来评估酒精暴露。乙基葡萄糖醛酸(EtG)和脂肪酸乙酯(FAEEs)通常用于测量酗酒高危人群(包括孕妇)的酒精摄入量:我们对胎粪样本中 EtG 和 FAEEs 均呈阳性或未呈阳性的两组 1.5 岁婴儿(母亲无酗酒史)进行了研究,并采用格里菲斯心理发育量表(GMDS)方法评估了他们的认知行为发育情况。我们的方案包括 8 例胎粪中酒精代谢物(EtG 和 FAEEs)呈阳性的婴儿和 7 例胎粪中酒精代谢物呈阴性的婴儿:结果:8 名胎粪中酒精代谢物呈阳性的婴儿均未表现出严重 FASD 的明显面部特征和生长迟缓,这表明 FASD 的发病可能与其他因素有关,但胎粪中 EtG 和 FAEEs 的升高与出生后一年半内的神经发育和适应功能紊乱有显著关联。事实上,我们发现胎粪中EtG和FAEEs均呈阳性的婴儿虽然没有表现出任何FASD形态学特征,但其自身运动能力的精细调节却出现了延迟:需要进一步分析和更大规模的研究来估算产前酒精暴露与各种相关疾病之间的正确联系,但本研究为 FASD 领域提供了一个新的步骤,以便为有风险的新生儿和婴儿提供早期治疗建议。
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引用次数: 0
Early identification of risk for eating disorders in Italian secondary school students: a cross-sectional study. 意大利中学生饮食失调风险的早期识别:一项横断面研究。
IF 2.7 4区 医学 Q4 PSYCHIATRY Pub Date : 2024-01-01 DOI: 10.1708/4205.41944
Enkeleda Gjini, Stefano Terzoni, Lara Carelli, Federico Ruta, Nicole Melillo, Sara Bertelli, Orsola Gambini, Armando D'Agostino, Paolo Ferrara

Aim: Eating disorders are major illnesses that primarily affect adolescents and young adults and seriously threaten public health. Early identification of at-risk individuals and timely initiation of treatment is crucial to improve outcomes. The Inside Out Institute Screener (IOI-S) is a rapid self-administration screening tool for high-risk and early-stage eating disorders. This study aimed to investigate the risk of having an eating disorder in a sample of Italian students by testing the Italian version of the IOI-S.

Methods: A multicentre cross-sectional study was conducted in a population of students aged 12-19 years; validity and reliability of the IOI-Sita were investigated.

Results: Four-hundred and ninety-one (81.97%) students were enrolled, 24.85% of whom were found to be at "very high risk" of an eating disorder, according to IOI-Sita. Younger (p<0.001) and female (p<0.001) students had higher risk scores. The EFA confirmed the original monodimensional structure of the tool, S-CVI=0.95%. The Content Validity Index of the scale (S-CVI) was 0.95, ω coefficient was 0.927.

Discussion and conclusions: This research confirms the need to screen for eating disorders in Italian youth adequately; the psychometric properties of the IOI-Sita confirm it as a valid and reliable tool for screening high-risk and early-stage eating disorders.

目的:进食障碍是一种主要影响青少年和年轻成年人的重大疾病,严重威胁公众健康。早期识别高危人群并及时开始治疗对改善治疗效果至关重要。内向外研究所筛查器(IOI-S)是一种针对高危和早期饮食失调的快速自我管理筛查工具。本研究旨在通过测试意大利语版的IOI-S,调查意大利学生患饮食失调症的风险:方法:在 12-19 岁的学生群体中开展了一项多中心横断面研究;对 IOI-Sita 的有效性和可靠性进行了调查:结果:共招募了 491 名学生(81.97%),根据 IOI-Sita,其中 24.85% 的学生被认定为饮食失调的 "高危人群"。讨论和结论:这项研究证实,有必要对意大利青少年的饮食失调症进行充分筛查;IOI-Sita 的心理测量特性证实,它是筛查高危和早期饮食失调症的有效、可靠的工具。
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