Pub Date : 2025-12-03DOI: 10.1080/08820538.2025.2588663
Jeonghyun Esther Kwon, Amirhossein Moghtader, Christie Kang, Zahra Bibak Bejandi, Sumaiya Shahjahan, Ahmad Alzein, Sandeep Jain, Mohammad Soleimani, Ali R Djalilian
Introduction: Ocular cicatricial pemphigoid (OCP) is a chronic autoimmune condition characterized by recurrent conjunctival inflammation and progressive cicatrization, affecting nearly 70% of mucous membrane pemphigoid patients and potentially leading to blindness. Literature suggests an association between OCP and malignancy.
Methods: This case series reports on 10 clinically diagnosed OCP patients with solid malignancies seen at the Illinois Eye and Ear Infirmary between January 2019 and January 2025. In addition, a review of current literature on the association between OCP and cancer was conducted using MEDLINE and Google Scholar databases.
Results: Six patients had an OCP diagnosis before their cancer diagnosis, three had a cancer diagnosis prior to OCP diagnosis, and one had both simultaneously. Patients diagnosed with cancer after OCP experienced clinically worsening OCP, while those with prior cancer diagnosis had stable OCP.
Discussions: Given the potential association with malignancy, patients with OCP or cicatricial conjunctivitis should undergo thorough systemic histories, age-appropriate cancer screenings, and patient education within a multidisciplinary care model to optimize early screening and improve the ocular and overall health outcomes.
{"title":"Ocular Cicatricial Pemphigoid and Solid Tumors: Review with Case Series.","authors":"Jeonghyun Esther Kwon, Amirhossein Moghtader, Christie Kang, Zahra Bibak Bejandi, Sumaiya Shahjahan, Ahmad Alzein, Sandeep Jain, Mohammad Soleimani, Ali R Djalilian","doi":"10.1080/08820538.2025.2588663","DOIUrl":"https://doi.org/10.1080/08820538.2025.2588663","url":null,"abstract":"<p><strong>Introduction: </strong>Ocular cicatricial pemphigoid (OCP) is a chronic autoimmune condition characterized by recurrent conjunctival inflammation and progressive cicatrization, affecting nearly 70% of mucous membrane pemphigoid patients and potentially leading to blindness. Literature suggests an association between OCP and malignancy.</p><p><strong>Methods: </strong>This case series reports on 10 clinically diagnosed OCP patients with solid malignancies seen at the Illinois Eye and Ear Infirmary between January 2019 and January 2025. In addition, a review of current literature on the association between OCP and cancer was conducted using MEDLINE and Google Scholar databases.</p><p><strong>Results: </strong>Six patients had an OCP diagnosis before their cancer diagnosis, three had a cancer diagnosis prior to OCP diagnosis, and one had both simultaneously. Patients diagnosed with cancer after OCP experienced clinically worsening OCP, while those with prior cancer diagnosis had stable OCP.</p><p><strong>Discussions: </strong>Given the potential association with malignancy, patients with OCP or cicatricial conjunctivitis should undergo thorough systemic histories, age-appropriate cancer screenings, and patient education within a multidisciplinary care model to optimize early screening and improve the ocular and overall health outcomes.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-12"},"PeriodicalIF":2.3,"publicationDate":"2025-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145669674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1080/08820538.2026.2598173
Mohammad Javed Ali
{"title":"Lacrimal History - Part 83: Doyens of Dacryology Series - Rudolf Robert Maier (1824-1888), Sinus of Maier, and Histology of the Lacrimal Mucosa.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2026.2598173","DOIUrl":"https://doi.org/10.1080/08820538.2026.2598173","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655345","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-01DOI: 10.1080/08820538.2026.2598172
Mohammad Javed Ali
{"title":"Lacrimal History - Part 82: Doyens of Dacryology Series - Jonathan Wathen (1728-1808) and His New Method and Apparatus for the Cure of Fistula Lachrymalis.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2026.2598172","DOIUrl":"https://doi.org/10.1080/08820538.2026.2598172","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-8"},"PeriodicalIF":2.3,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145655361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1080/08820538.2025.2596385
Mohini Agrawal, K Shyamsundar, Keerthana Raghu, Rajiv Raman, L Dhanurekha, Radha Annamalai, Avinash Mishra, Jyotirmay Biswas
Background: Intraocular tuberculosis (OTb) is a sight-threatening manifestation of Mycobaterium tuberculosis infection. It is characterized by a wide spectrum of clinical phenotypes, including anterior uveitis, posterior uveitis, retinal vasculitis, and choroiditis. Diagnosis remains challenging due to its diverse clinical presentations and the absence of standardized criteria. This review summarizes current knowledge on the clinical spectrum, diagnostic modalities, and emerging management strategies for OTb.
Methods: A comprehensive systemic literature search was conducted on Medline and PubMed to identify relevant studies on ocular tuberculosis.
Results: Key diagnostic tools include optical coherence tomography (OCT), fluorescein angiography (FA), interferon-gamma release assays (IGRA), polymerase chain reaction (PCR), and high-resolution computerized tomography (HRCT). Management typically involves a combination of anti-tuberculosis therapy (ATT) and corticosteroids, although optimal treatment regimens remain a topic of ongoing debate. Emerging challenges in treatment include paradoxical worsening, drug resistance, and corticosteroid dependency. Recent advancements, such as intravitreal anti-VEGF agents, moxifloxacin, and immunomodulatory therapy, have shown promise in refractory cases.
Conclusion: A multidisciplinary approach is essential for the timely diagnosis, individualized treatment, and improved visual outcomes in patients with intraocular tuberculosis.
{"title":"Intraocular Tuberculosis: Current Insights and Emerging Therapeutic Paradigms.","authors":"Mohini Agrawal, K Shyamsundar, Keerthana Raghu, Rajiv Raman, L Dhanurekha, Radha Annamalai, Avinash Mishra, Jyotirmay Biswas","doi":"10.1080/08820538.2025.2596385","DOIUrl":"https://doi.org/10.1080/08820538.2025.2596385","url":null,"abstract":"<p><strong>Background: </strong>Intraocular tuberculosis (OTb) is a sight-threatening manifestation of Mycobaterium tuberculosis infection. It is characterized by a wide spectrum of clinical phenotypes, including anterior uveitis, posterior uveitis, retinal vasculitis, and choroiditis. Diagnosis remains challenging due to its diverse clinical presentations and the absence of standardized criteria. This review summarizes current knowledge on the clinical spectrum, diagnostic modalities, and emerging management strategies for OTb.</p><p><strong>Methods: </strong>A comprehensive systemic literature search was conducted on Medline and PubMed to identify relevant studies on ocular tuberculosis.</p><p><strong>Results: </strong>Key diagnostic tools include optical coherence tomography (OCT), fluorescein angiography (FA), interferon-gamma release assays (IGRA), polymerase chain reaction (PCR), and high-resolution computerized tomography (HRCT). Management typically involves a combination of anti-tuberculosis therapy (ATT) and corticosteroids, although optimal treatment regimens remain a topic of ongoing debate. Emerging challenges in treatment include paradoxical worsening, drug resistance, and corticosteroid dependency. Recent advancements, such as intravitreal anti-VEGF agents, moxifloxacin, and immunomodulatory therapy, have shown promise in refractory cases.</p><p><strong>Conclusion: </strong>A multidisciplinary approach is essential for the timely diagnosis, individualized treatment, and improved visual outcomes in patients with intraocular tuberculosis.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-17"},"PeriodicalIF":2.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-28DOI: 10.1080/08820538.2025.2596539
Mohammad Javed Ali
{"title":"Lacrimal History - Part 80: Doyens of Dacryology Series - The Lesser-Known Lacrimal Surgeons Documented by Julius Hirschberg (1843-1925).","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2596539","DOIUrl":"https://doi.org/10.1080/08820538.2025.2596539","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-5"},"PeriodicalIF":2.3,"publicationDate":"2025-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-27DOI: 10.1080/08820538.2025.2596540
Mohammad Javed Ali
{"title":"Lacrimal History - Part 81: Doyens of Dacryology Series - Alexander Manson (1774-1840) and Iodine as a Curative Agent for Fistula Lachyrmalis.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2596540","DOIUrl":"https://doi.org/10.1080/08820538.2025.2596540","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-5"},"PeriodicalIF":2.3,"publicationDate":"2025-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145638742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1080/08820538.2025.2593805
Mohammad Javed Ali
{"title":"Lacrimal History - Part 74: Doyens of Dacryology Series - Lacrimal Sac Extirpation and Early Evolution of Modern Dacryocystectomy from 1886 to 1908: J.B. Lawford, Fred T. Tooke, Freeland A. Fergus, A.L. M'Millan, and Robert H. Elliot.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2593805","DOIUrl":"https://doi.org/10.1080/08820538.2025.2593805","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-9"},"PeriodicalIF":2.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-21DOI: 10.1080/08820538.2025.2593806
Mohammad Javed Ali
{"title":"Lacrimal History - Part 79: Doyens of Dacryology Series - Erik Johan Widmark (1850-1909) and the Bacteriology of Lacrimal Sac.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2593806","DOIUrl":"https://doi.org/10.1080/08820538.2025.2593806","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-3"},"PeriodicalIF":2.3,"publicationDate":"2025-11-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145574274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1080/08820538.2025.2589607
Mohammad Javed Ali
{"title":"Lacrimal History - Part 77: Doyens of Dacryology Series - Jakob Stilling (1842-1915) and Charles Hermon Thomas and the Early Concepts of Lacrimal Stricturoplasty Using Stricturotomoes.","authors":"Mohammad Javed Ali","doi":"10.1080/08820538.2025.2589607","DOIUrl":"https://doi.org/10.1080/08820538.2025.2589607","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-6"},"PeriodicalIF":2.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-11-18DOI: 10.1080/08820538.2025.2589606
Mohammad Javed Ali, Bhupendra C K Patel
{"title":"Lacrimal History - Part 76: Doyens of Dacryology Series - Richard Alexander Norton Welham (1936-).","authors":"Mohammad Javed Ali, Bhupendra C K Patel","doi":"10.1080/08820538.2025.2589606","DOIUrl":"https://doi.org/10.1080/08820538.2025.2589606","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":" ","pages":"1-4"},"PeriodicalIF":2.3,"publicationDate":"2025-11-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145550057","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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