Purpose: We aimed to describe changes in the geographic distribution of self-reported visual impairment (VI) over the last decade (2010-2019) in the U.S.
Methods: Our study was an analysis of publicly available data collected between 2010 and 2019 from the Census Bureau American Community Survey.
Results: The mean overall prevalence of self-reported VI from 2010 to 2019 was 2.31% in the United States, and there was a significant increase in VI over the past decade from 2.25% in 2010-2014 to 2.37% in 2015-2019 (p < .001). VI was significantly higher in rural counties (3.58%), compared to urban (3.10%) or metropolitan counties (2.18%) (p < .001). In terms of geographic region, the South of the United States had the highest rate of VI (2.63%) (p < .001). For age groups > 17-years-old in the 2010-2019 data, women had higher rates of VI compared to men.
Conclusions: Prevalence of self-reported visual impairment has risen and disproportionately affects certain communities. This includes individuals living in the South, in rural counties, and women.
目的:我们旨在描述过去十年(2010-2019年)美国自我报告的视觉障碍(VI)地理分布的变化。方法:我们的研究分析了人口普查局美国社区调查在2010年至2019年间收集的公开数据在过去十年中,VI从2010-2014年的2.25%显著增加到2015-2019年的2.37%(p p p 在2010-2019年的数据中,17岁的女性VI发病率高于男性。结论:自我报告的视力障碍的患病率有所上升,并对某些社区产生了不成比例的影响。这包括生活在南方、农村县的个人和妇女。
{"title":"Trends in Geographic Distribution of Visual Disability - United States, 2010-2019.","authors":"Lucy V Cobbs, Raziyeh Mahmoudzadeh, Mirataollah Salabati, Jacquelyn Hamati, Yoshihiro Yonekawa, Rebecca Russ Soares","doi":"10.1080/08820538.2023.2273855","DOIUrl":"10.1080/08820538.2023.2273855","url":null,"abstract":"<p><strong>Purpose: </strong>We aimed to describe changes in the geographic distribution of self-reported visual impairment (VI) over the last decade (2010-2019) in the U.S.</p><p><strong>Methods: </strong>Our study was an analysis of publicly available data collected between 2010 and 2019 from the Census Bureau American Community Survey.</p><p><strong>Results: </strong>The mean overall prevalence of self-reported VI from 2010 to 2019 was 2.31% in the United States, and there was a significant increase in VI over the past decade from 2.25% in 2010-2014 to 2.37% in 2015-2019 (<i>p</i> < .001). VI was significantly higher in rural counties (3.58%), compared to urban (3.10%) or metropolitan counties (2.18%) (<i>p</i> < .001). In terms of geographic region, the South of the United States had the highest rate of VI (2.63%) (<i>p</i> < .001). For age groups > 17-years-old in the 2010-2019 data, women had higher rates of VI compared to men.</p><p><strong>Conclusions: </strong>Prevalence of self-reported visual impairment has risen and disproportionately affects certain communities. This includes individuals living in the South, in rural counties, and women.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"50158687","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2024-02-09DOI: 10.1080/08820538.2024.2308248
David Restrepo, Justin Michael Quion, Frederico Do Carmo Novaes, Iago Diogenes Azevedo Costa, Constanza Vasquez, Alyssa Nicole Bautista, Ellaine Quiminiano, Patricia Abigail Lim, Roger Mwavu, Leo Anthony Celi, Luis Filipe Nakayama
Background: Imaging plays a pivotal role in eye assessment. With the introduction of advanced machine learning and artificial intelligence (AI), the focus has shifted to imaging datasets in ophthalmology. While disparities and health inequalities hidden within data are well-documented, the ophthalmology field faces specific challenges to the creation and maintenance of datasets. Optical Coherence Tomography (OCT) is useful for the diagnosis and monitoring of retinal pathologies, making it valuable for AI applications. This review aims to identify and compare the landscape of publicly available optical coherence tomography databases for AI applications.
Methods: We conducted a literature review on OCT and AI articles with publicly accessible datasets, using PubMed, Scopus, and Web of Science databases. The review retrieved 183 articles, and after full-text analysis, 50 articles were included. From the included articles were identified 8 publicly available OCT datasets, focusing on patient demographics and clinical details for thorough assessment and comparison.
Results: The resulting datasets encompass 154,313 images collected from Spectralis, Cirrus HD, Topcon 3D, and Bioptigen devices. These datasets included normal exams, age-related macular degeneration, and diabetic maculopathy, among others. Comprehensive demographic information is available in one dataset and the USA is the most represented population.
Discussion: Current publicly available OCT databases for AI applications exhibit limitations, stemming from their non-representative nature and the lack of comprehensive demographic information. Limited datasets hamper research and equitable AI development. To promote equitable AI algorithmic development in ophthalmology, there is a need for the creation and dissemination of more representative datasets.
背景:成像在眼科评估中起着举足轻重的作用。随着先进的机器学习和人工智能(AI)的引入,眼科成像数据集已成为关注的焦点。虽然隐藏在数据中的差异和健康不平等问题已得到充分证实,但眼科领域在数据集的创建和维护方面面临着特殊的挑战。光学相干断层扫描(OCT)可用于诊断和监测视网膜病变,因此对人工智能应用非常有价值。本综述旨在确定和比较用于人工智能应用的公开光学相干断层扫描数据库的情况:我们使用 PubMed、Scopus 和 Web of Science 数据库,对可公开访问数据集的光学相干断层扫描和人工智能文章进行了文献综述。综述共检索到 183 篇文章,经过全文分析,共纳入 50 篇文章。从收录的文章中确定了 8 个可公开获取的 OCT 数据集,重点关注患者人口统计学和临床细节,以便进行全面评估和比较:结果:数据集包括从 Spectralis、Cirrus HD、Topcon 3D 和 Bioptigen 设备收集的 154,313 幅图像。这些数据集包括正常检查、老年性黄斑变性和糖尿病性黄斑病变等。在一个数据集中提供了全面的人口统计信息,美国是代表性最强的人群:讨论:目前用于人工智能应用的公开 OCT 数据库具有局限性,原因在于其不具代表性和缺乏全面的人口统计学信息。有限的数据集阻碍了研究和公平的人工智能发展。为了促进眼科人工智能算法的公平发展,有必要创建和传播更具代表性的数据集。
{"title":"Ophthalmology Optical Coherence Tomography Databases for Artificial Intelligence Algorithm: A Review.","authors":"David Restrepo, Justin Michael Quion, Frederico Do Carmo Novaes, Iago Diogenes Azevedo Costa, Constanza Vasquez, Alyssa Nicole Bautista, Ellaine Quiminiano, Patricia Abigail Lim, Roger Mwavu, Leo Anthony Celi, Luis Filipe Nakayama","doi":"10.1080/08820538.2024.2308248","DOIUrl":"10.1080/08820538.2024.2308248","url":null,"abstract":"<p><strong>Background: </strong>Imaging plays a pivotal role in eye assessment. With the introduction of advanced machine learning and artificial intelligence (AI), the focus has shifted to imaging datasets in ophthalmology. While disparities and health inequalities hidden within data are well-documented, the ophthalmology field faces specific challenges to the creation and maintenance of datasets. Optical Coherence Tomography (OCT) is useful for the diagnosis and monitoring of retinal pathologies, making it valuable for AI applications. This review aims to identify and compare the landscape of publicly available optical coherence tomography databases for AI applications.</p><p><strong>Methods: </strong>We conducted a literature review on OCT and AI articles with publicly accessible datasets, using PubMed, Scopus, and Web of Science databases. The review retrieved 183 articles, and after full-text analysis, 50 articles were included. From the included articles were identified 8 publicly available OCT datasets, focusing on patient demographics and clinical details for thorough assessment and comparison.</p><p><strong>Results: </strong>The resulting datasets encompass 154,313 images collected from Spectralis, Cirrus HD, Topcon 3D, and Bioptigen devices. These datasets included normal exams, age-related macular degeneration, and diabetic maculopathy, among others. Comprehensive demographic information is available in one dataset and the USA is the most represented population.</p><p><strong>Discussion: </strong>Current publicly available OCT databases for AI applications exhibit limitations, stemming from their non-representative nature and the lack of comprehensive demographic information. Limited datasets hamper research and equitable AI development. To promote equitable AI algorithmic development in ophthalmology, there is a need for the creation and dissemination of more representative datasets.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139707787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2024-01-18DOI: 10.1080/08820538.2024.2306434
Mohammad Javed Ali, Ali Djalilian
{"title":"Readership Awareness Series - Paper 9: Retraction of a Publication.","authors":"Mohammad Javed Ali, Ali Djalilian","doi":"10.1080/08820538.2024.2306434","DOIUrl":"10.1080/08820538.2024.2306434","url":null,"abstract":"","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139491965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The purpose of this study was to determine whether specific genetic polymorphisms affect the response to intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with macular oedema secondary to retinal vein occlusion (RVO).
Methods: Participants in this prospective study were 50 patients with macular oedema secondary to RVO, who were treated with intravitreal ranibizumab or aflibercept, and were followed-up for 12 months after initiation of treatment. Five single nucleotide polymorphisms (SNPs) from three different genes (APOE, PON1, SDF-1) were examined as potential predictors for treatment response to intravitreal anti-VEGF agents.
Results: Patients with the LL genotype of the PON1 L55M SNP had significantly higher reduction in central subfield thickness (CST) at month 12 after initiation of intravitreal anti-VEGF treatment (101.63 ± 56.80 μm in LL vs. 72.44 ± 39.41 μm in LM vs. 40.25 ± 19.33 μm in MM, p = .026). Patients with the M allele of the PON1 L55M SNP were significantly associated with lower reduction in CST compared to non-carriers (68.29 ± 38.77 μm in LM + MM vs. 101.63 ± 56.80 μm in LL, p = .032).
Conclusion: PON1 L55M SNP may serve as a promising genetic biomarker for predicting response to intravitreal anti-VEGF treatment in patients with macular oedema due to RVO.
目的:本研究的目的是确定特异性遗传多态性是否影响视网膜静脉闭塞(RVO)继发性黄斑水肿患者对玻璃体内抗血管内皮生长因子(anti-VEGF)治疗的反应。方法:这项前瞻性研究的参与者是50例继发于RVO的黄斑水肿患者,他们接受了玻璃体内雷尼单抗或阿非利塞普治疗,并在开始治疗后随访了12个月。来自三个不同基因(APOE, PON1, SDF-1)的五个单核苷酸多态性(snp)被检测为玻璃体内抗vegf药物治疗反应的潜在预测因子。结果:PON1 L55M SNP的LL基因型患者在开始玻璃体内抗vegf治疗后12个月的中心亚场厚度(CST)降低率显著高于LL(101.63±56.80 μm), LM(72.44±39.41 μm), MM(40.25±19.33 μm), p = 0.026。与非携带者相比,携带PON1 L55M SNP M等位基因的患者CST降低显著相关(LM + MM为68.29±38.77 μm, LL为101.63±56.80 μm, p = 0.032)。结论:PON1 L55M SNP可能作为预测RVO黄斑水肿患者玻璃体内抗vegf治疗反应的有希望的遗传生物标志物。
{"title":"Association of <i>PON1</i>, <i>APOE</i> and <i>SDF-1</i> Gene Polymorphisms with Treatment Response to Intravitreal Anti-VEGF Treatment in Patients with Retinal Vein Occlusion.","authors":"Antonios Ragkousis, Dimitrios Kazantzis, Ilias Georgalas, Panagiotis Theodossiadis, Christos Kroupis, Irini Chatziralli","doi":"10.1080/08820538.2023.2283028","DOIUrl":"10.1080/08820538.2023.2283028","url":null,"abstract":"<p><strong>Purpose: </strong>The purpose of this study was to determine whether specific genetic polymorphisms affect the response to intravitreal anti-vascular endothelial growth factor (anti-VEGF) treatment in patients with macular oedema secondary to retinal vein occlusion (RVO).</p><p><strong>Methods: </strong>Participants in this prospective study were 50 patients with macular oedema secondary to RVO, who were treated with intravitreal ranibizumab or aflibercept, and were followed-up for 12 months after initiation of treatment. Five single nucleotide polymorphisms (SNPs) from three different genes (<i>APOE</i>, <i>PON1</i>, <i>SDF-1</i>) were examined as potential predictors for treatment response to intravitreal anti-VEGF agents.</p><p><strong>Results: </strong>Patients with the LL genotype of the <i>PON1</i> L55M SNP had significantly higher reduction in central subfield thickness (CST) at month 12 after initiation of intravitreal anti-VEGF treatment (101.63 ± 56.80 μm in LL vs. 72.44 ± 39.41 μm in LM vs. 40.25 ± 19.33 μm in MM, <i>p</i> = .026). Patients with the M allele of the <i>PON1</i> L55M SNP were significantly associated with lower reduction in CST compared to non-carriers (68.29 ± 38.77 μm in LM + MM vs. 101.63 ± 56.80 μm in LL, <i>p</i> = .032).</p><p><strong>Conclusion: </strong><i>PON1</i> L55M SNP may serve as a promising genetic biomarker for predicting response to intravitreal anti-VEGF treatment in patients with macular oedema due to RVO.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138299944","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: To evaluate the long-term efficacy of selective laser trabeculoplasty (SLT) in eyes with primary angle-closure (PAC) and primary angle-closure glaucoma (PACG) following a laser peripheral iridotomy (LPI).
Method: In this prospective cross-sectional study, 45 eyes of 34 patients with PAC/PACG diagnosis, uncontrolled intraocular pressure (IOP), and visible pigmented trabecular-meshwork (TM) at least 180° on gonioscopy following a LPI were recruited. Following a detailed baseline ophthalmic evaluation, all eligible eyes underwent SLT, and the patients were examined on day1, at 1 week, 1-, 3-, and 6-months, and 1-, 2-, 3-, 4-, and 5-year subsequently. The main outcomes measured were IOP, number of IOP-lowering agents, and complications.
Results: The mean age of the cohort was 57.80 ± 6.44 years, the male-female ratio was 8:26, and 17 eyes were PACG, and 28 were PAC. The baseline IOP was 23.81 ± 1.78 mm Hg, and was significantly declined at all follow-ups (p < .0001). The cumulative probability of overall success was 91% and 84% at 2-, and 5-year, respectively. At 5-year SLT provided drug-freedom in 80% of PAC and 23% of PACG eyes. Six eyes had IOP spike at 1-week and two patients underwent repeat SLT after 1-year. No other complications, such as pain/discomfort, inflammation, an increase in peripheral anterior synechiae and cystoid-macular-edema, were noted.
Conclusions: SLT appears a safe and cost-effective procedure in PAC/mild- moderate PACG eyes with uncontrolled IOP after laser iridotomy. The long-term effectiveness of SLT as adjuvant treatment was good, but need large sized randomized studies for more validation.
{"title":"Long-Term Efficacy of Selective Laser Trabeculoplasty in Primary Angle-Closure Disease After Laser Peripheral Iridotomy.","authors":"Srishti Raj, Faisal Thattaruthody, Deepti Yadav, Deeksha Sharma, Basavaraj Tigari, Deepika Dhingra, Sushmita Kaushik, Surinder S Pandav","doi":"10.1080/08820538.2024.2312946","DOIUrl":"https://doi.org/10.1080/08820538.2024.2312946","url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the long-term efficacy of selective laser trabeculoplasty (SLT) in eyes with primary angle-closure (PAC) and primary angle-closure glaucoma (PACG) following a laser peripheral iridotomy (LPI).</p><p><strong>Method: </strong>In this prospective cross-sectional study, 45 eyes of 34 patients with PAC/PACG diagnosis, uncontrolled intraocular pressure (IOP), and visible pigmented trabecular-meshwork (TM) at least 180° on gonioscopy following a LPI were recruited. Following a detailed baseline ophthalmic evaluation, all eligible eyes underwent SLT, and the patients were examined on day1, at 1 week, 1-, 3-, and 6-months, and 1-, 2-, 3-, 4-, and 5-year subsequently. The main outcomes measured were IOP, number of IOP-lowering agents, and complications.</p><p><strong>Results: </strong>The mean age of the cohort was 57.80 ± 6.44 years, the male-female ratio was 8:26, and 17 eyes were PACG, and 28 were PAC. The baseline IOP was 23.81 ± 1.78 mm Hg, and was significantly declined at all follow-ups (<i>p</i> < .0001). The cumulative probability of overall success was 91% and 84% at 2-, and 5-year, respectively. At 5-year SLT provided drug-freedom in 80% of PAC and 23% of PACG eyes. Six eyes had IOP spike at 1-week and two patients underwent repeat SLT after 1-year. No other complications, such as pain/discomfort, inflammation, an increase in peripheral anterior synechiae and cystoid-macular-edema, were noted.</p><p><strong>Conclusions: </strong>SLT appears a safe and cost-effective procedure in PAC/mild- moderate PACG eyes with uncontrolled IOP after laser iridotomy. The long-term effectiveness of SLT as adjuvant treatment was good, but need large sized randomized studies for more validation.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139973354","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01Epub Date: 2023-10-18DOI: 10.1080/08820538.2023.2271063
Gema Corpus, Ainhoa Molina-Martin, David P Piñero
Purpose: To summarize and analyze critically the scientific evidence focused on the effectiveness of the use of hydrophilic contact lenses (HCLs) in myopia control, as well as their impact on visual quality and the involvement on the accommodative and binocular function.
Methods: This systematic review was developed selecting all original studies which evaluated HCLs for myopia control with follow-up of at least 1 year. Eligible randomized controlled trials (RCTs) were retrieved from PubMed MEDLINE and Scopus. Methodological quality of the studies was assessed using the Critical Appraisal Skills Programme (CASP) for RCTs.
Results: The search provided a total of 276 articles, selecting 13 according to the inclusion and exclusion criteria. The majority of studies evaluating the effectiveness of HCL showed a good efficacy in myopia progression, providing a good quality of vision. The quality of these studies was found to be suitable according to the CASP tool. The accommodative and binocular function with these lenses was evaluated in few studies, reporting a trend to an increase in the accommodative response and exophoria in near vision, while maintaining good level of stereopsis. Aberrometry and pupillometry were only studied in one trial, in which the authors did not find changes in these variables after the use of a myopia control HCL.
Conclusions: There is a strong evidence about the effectiveness of different HCLs designs for slowing down myopia progression in children, providing all of them good levels of visual quality. However, there is still poor evidence about changes in accommodation and binocular function, as well as in pupil size and aberrometry with myopia control HCLs, being necessary more studies focused on this issue.
{"title":"Efficacy of Soft Contact Lenses for Myopia Control: A Systematic Review.","authors":"Gema Corpus, Ainhoa Molina-Martin, David P Piñero","doi":"10.1080/08820538.2023.2271063","DOIUrl":"10.1080/08820538.2023.2271063","url":null,"abstract":"<p><strong>Purpose: </strong>To summarize and analyze critically the scientific evidence focused on the effectiveness of the use of hydrophilic contact lenses (HCLs) in myopia control, as well as their impact on visual quality and the involvement on the accommodative and binocular function.</p><p><strong>Methods: </strong>This systematic review was developed selecting all original studies which evaluated HCLs for myopia control with follow-up of at least 1 year. Eligible randomized controlled trials (RCTs) were retrieved from PubMed MEDLINE and Scopus. Methodological quality of the studies was assessed using the Critical Appraisal Skills Programme (CASP) for RCTs.</p><p><strong>Results: </strong>The search provided a total of 276 articles, selecting 13 according to the inclusion and exclusion criteria. The majority of studies evaluating the effectiveness of HCL showed a good efficacy in myopia progression, providing a good quality of vision. The quality of these studies was found to be suitable according to the CASP tool. The accommodative and binocular function with these lenses was evaluated in few studies, reporting a trend to an increase in the accommodative response and exophoria in near vision, while maintaining good level of stereopsis. Aberrometry and pupillometry were only studied in one trial, in which the authors did not find changes in these variables after the use of a myopia control HCL.</p><p><strong>Conclusions: </strong>There is a strong evidence about the effectiveness of different HCLs designs for slowing down myopia progression in children, providing all of them good levels of visual quality. However, there is still poor evidence about changes in accommodation and binocular function, as well as in pupil size and aberrometry with myopia control HCLs, being necessary more studies focused on this issue.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49682093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-18DOI: 10.1080/08820538.2024.2324057
Jeremy Goldfarb, Janet Fan, Luana Guimaraes de Sousa, Neal Akhave, Jeffrey Myers, Ryan Goepfert, Krish Manisundaram, Jiawei Zhao, Steven J Frank, Amy Moreno, Renata Ferrarotto, Bita Esmaeli
Background/aims: We describe our findings in patients with locally advanced lacrimal sac and nasolacrimal duct (NLD) carcinoma who received neoadjuvant systemic therapy.
Methods: We identified patients with locally advanced primary lacrimal sac/NLD carcinoma treated with neoadjuvant systemic intravenous therapy at our institution during 2017-2019.
Results: The study included seven patients, four men and three women; the mean age was 60.4 years (range: 43-76). All patients had locally advanced disease with significant orbital soft tissue invasion with or without skull base invasion making eye-sparing surgery not feasible as an initial step. Three patients had poorly differentiated squamous cell carcinoma; two, invasive carcinoma with basaloid and squamous features; one, high-grade carcinoma with features suggestive of sebaceous differentiation; and one, undifferentiated carcinoma. The neoadjuvant regimens were cisplatin and docetaxel (n = 1); carboplatin and docetaxel (n = 1); paclitaxel and cetuximab (n = 1); carboplatin, paclitaxel, and cetuximab (EGFR inhibitor) (n = 2); cisplatin, docetaxel, and pembrolizumab (anti-PD-1 immunotherapy) (n = 1); and carboplatin, paclitaxel, and pembrolizumab (n = 1). All patients had radiologic disease regression, and one patient had radiologic near-complete response. After neoadjuvant therapy, all patients underwent wide local excision and adjuvant concurrent chemoradiation. Two patients had a complete pathologic response. At a median follow-up period of 13 months after chemoradiation (range, 8-54 months), all patients were alive without evidence of disease. One patient had nodal metastasis treated with lymph node dissection and adjuvant chemoradiation.
Conclusions: Neoadjuvant systemic therapy can shrink tumors in patients with locally advanced primary lacrimal sac/NLD carcinoma with orbital or skull base invasion.
{"title":"Neoadjuvant Chemotherapy Alone or Combined with EGFR-Directed Targeted Therapy or Anti-PD-1 Immunotherapy for Locally Advanced Lacrimal Sac and Nasolacrimal Duct Carcinomas.","authors":"Jeremy Goldfarb, Janet Fan, Luana Guimaraes de Sousa, Neal Akhave, Jeffrey Myers, Ryan Goepfert, Krish Manisundaram, Jiawei Zhao, Steven J Frank, Amy Moreno, Renata Ferrarotto, Bita Esmaeli","doi":"10.1080/08820538.2024.2324057","DOIUrl":"10.1080/08820538.2024.2324057","url":null,"abstract":"<p><strong>Background/aims: </strong>We describe our findings in patients with locally advanced lacrimal sac and nasolacrimal duct (NLD) carcinoma who received neoadjuvant systemic therapy.</p><p><strong>Methods: </strong>We identified patients with locally advanced primary lacrimal sac/NLD carcinoma treated with neoadjuvant systemic intravenous therapy at our institution during 2017-2019.</p><p><strong>Results: </strong>The study included seven patients, four men and three women; the mean age was 60.4 years (range: 43-76). All patients had locally advanced disease with significant orbital soft tissue invasion with or without skull base invasion making eye-sparing surgery not feasible as an initial step. Three patients had poorly differentiated squamous cell carcinoma; two, invasive carcinoma with basaloid and squamous features; one, high-grade carcinoma with features suggestive of sebaceous differentiation; and one, undifferentiated carcinoma. The neoadjuvant regimens were cisplatin and docetaxel (<i>n</i> = 1); carboplatin and docetaxel (<i>n</i> = 1); paclitaxel and cetuximab (<i>n</i> = 1); carboplatin, paclitaxel, and cetuximab (EGFR inhibitor) (<i>n</i> = 2); cisplatin, docetaxel, and pembrolizumab (anti-PD-1 immunotherapy) (<i>n</i> = 1); and carboplatin, paclitaxel, and pembrolizumab (<i>n</i> = 1). All patients had radiologic disease regression, and one patient had radiologic near-complete response. After neoadjuvant therapy, all patients underwent wide local excision and adjuvant concurrent chemoradiation. Two patients had a complete pathologic response. At a median follow-up period of 13 months after chemoradiation (range, 8-54 months), all patients were alive without evidence of disease. One patient had nodal metastasis treated with lymph node dissection and adjuvant chemoradiation.</p><p><strong>Conclusions: </strong>Neoadjuvant systemic therapy can shrink tumors in patients with locally advanced primary lacrimal sac/NLD carcinoma with orbital or skull base invasion.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.9,"publicationDate":"2024-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11408703/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140158968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Purpose: The aim of this study was to analyze the characteristics of CT-measured intersection angle (FB-BNLD) between the frontal bone and bony nasolacrimal duct and to provide suggestions for treating primary acquired nasolacrimal duct obstruction (PANDO) patients in West China.
Methods: Three hundred and nine participants' CT were, respectively, evaluated with RadiAnt DICOM Viewer. We defined the FB-BNLD angle >0° as the anterior type and the FB-BNLD angle ≤0° as the posterior type.
Results: The mean FB-BNLD was -2.52° (95% CI, -3.16° to -1.88°) across all participants, of whom 37.2% were of the anterior type and 62.8% of the posterior type. Approximately 65.0% of the female patients had a posterior FB-BNLD type, and 54.2% of the male patients had an anterior FB-BNLD type (p = .002). Posterior FB-BNLD was the dominant type in the PANDO and control groups (p = .011), and the angle of FB-BNLD was statistically different in both groups (PANDO group, -2.54° to -0.71°; control group, -4.42° to -2.67°; p < .001). Among the male participants, the type of FB-BNLD differed between the two groups (p = .036), with differences in the angle of FB-BNLD (PANDO group, 0.59° to 5.13°; control group, -4.08° to 1.89°; p = .034). There was no difference in the type of FB-BNLD in female participants between the two groups (p = .051).
Conclusion: The present study revealed individual differences in the type of FB-BNLD, with anterior-type majority in males and posterior-type dominance in females. Evaluating the FB-BNLD type on CT can provide a fast method for knowing the nasolacrimal duct condition during planning for lacrimal manipulation.
{"title":"CT-Measured Angulation Between the Frontal Bone and Bony Nasolacrimal Duct: Variations in Obstructed and Healthy Lacrimal Ducts.","authors":"Yong Liu, Aixin Jiang, Shihuai Nie, Shujuan Cao, Aizezi Wumaier, Ruxin Ding, Mayila Kuerban, Renbing Zhou, Fangzeng Lin, Huasheng Yang, Xuanwei Liang, Danping Huang, Rongxin Chen","doi":"10.1080/08820538.2024.2330501","DOIUrl":"https://doi.org/10.1080/08820538.2024.2330501","url":null,"abstract":"<p><strong>Purpose: </strong>The aim of this study was to analyze the characteristics of CT-measured intersection angle (FB-BNLD) between the frontal bone and bony nasolacrimal duct and to provide suggestions for treating primary acquired nasolacrimal duct obstruction (PANDO) patients in West China.</p><p><strong>Methods: </strong>Three hundred and nine participants' CT were, respectively, evaluated with RadiAnt DICOM Viewer. We defined the FB-BNLD angle >0° as the anterior type and the FB-BNLD angle ≤0° as the posterior type.</p><p><strong>Results: </strong>The mean FB-BNLD was -2.52° (95% CI, -3.16° to -1.88°) across all participants, of whom 37.2% were of the anterior type and 62.8% of the posterior type. Approximately 65.0% of the female patients had a posterior FB-BNLD type, and 54.2% of the male patients had an anterior FB-BNLD type (<i>p</i> = .002). Posterior FB-BNLD was the dominant type in the PANDO and control groups (<i>p</i> = .011), and the angle of FB-BNLD was statistically different in both groups (PANDO group, -2.54° to -0.71°; control group, -4.42° to -2.67°; <i>p</i> < .001). Among the male participants, the type of FB-BNLD differed between the two groups (<i>p</i> = .036), with differences in the angle of FB-BNLD (PANDO group, 0.59° to 5.13°; control group, -4.08° to 1.89°; <i>p</i> = .034). There was no difference in the type of FB-BNLD in female participants between the two groups (<i>p</i> = .051).</p><p><strong>Conclusion: </strong>The present study revealed individual differences in the type of FB-BNLD, with anterior-type majority in males and posterior-type dominance in females. Evaluating the FB-BNLD type on CT can provide a fast method for knowing the nasolacrimal duct condition during planning for lacrimal manipulation.</p>","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140140648","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-05DOI: 10.1080/08820538.2024.2324450
Dr.Utku Limon, Fatih Bilgehan Kaplan, Işılay Saygın, Ecem Önder Tokuç, Işıl Kutlutürk Karagöz, Hatice Selen Kanar, Mehmet Orkun Sevik, Uğur Yayla, Erkan Çelik, Ayşe Sönmez, Aslan Aykut, Esra Kumral Türkseven, Nimet Yeşim Erçalık, Özlem Oncu Aydın, Erdinç Bozkurt, Tuğba Aydoğan, Ece Başaran Emengen, Abdullah Özkaya, Banu Açıkalın Öncel, Nursal Melda Yenerel, Özlem Şahin, Levent Karabaş
To evaluate the responses of different optical coherence tomography (OCT) patterns of diabetic macular edema (DME) to intravitreal injection therapy.In this retrospective, comparative, and multicen...
评估不同光学相干断层扫描(OCT)模式的糖尿病性黄斑水肿(DME)对玻璃体内注射疗法的反应。
{"title":"One-Year Functional and Morphological Prognosis After Intravitreal Injection Treatments According to Different Morphological Patterns of Diabetic Macular Edema in Real-Life: MARMASIA Study Group Report No.13","authors":"Dr.Utku Limon, Fatih Bilgehan Kaplan, Işılay Saygın, Ecem Önder Tokuç, Işıl Kutlutürk Karagöz, Hatice Selen Kanar, Mehmet Orkun Sevik, Uğur Yayla, Erkan Çelik, Ayşe Sönmez, Aslan Aykut, Esra Kumral Türkseven, Nimet Yeşim Erçalık, Özlem Oncu Aydın, Erdinç Bozkurt, Tuğba Aydoğan, Ece Başaran Emengen, Abdullah Özkaya, Banu Açıkalın Öncel, Nursal Melda Yenerel, Özlem Şahin, Levent Karabaş","doi":"10.1080/08820538.2024.2324450","DOIUrl":"https://doi.org/10.1080/08820538.2024.2324450","url":null,"abstract":"To evaluate the responses of different optical coherence tomography (OCT) patterns of diabetic macular edema (DME) to intravitreal injection therapy.In this retrospective, comparative, and multicen...","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140033437","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-03-04DOI: 10.1080/08820538.2024.2323117
Vijayalakshmi A Senthilkumar, Narendra Wala, Sharmila Rajendrababu, Chitaranjan Mishra, Naresh Babu Kannan, Mohammed Sithiq Uduman
To describe the clinical presentation and treatment outcomes of pupillary block glaucoma (PBG) following vitreoretinal surgery (VR surgery).Retrospective observational study of 6941 patients, who u...
描述玻璃体视网膜手术(VR)后瞳孔阻滞性青光眼(PBG)的临床表现和治疗效果。
{"title":"Clinical Presentation and Treatment Outcomes of Pupillary Block Glaucoma Following Vitreoretinal Surgery","authors":"Vijayalakshmi A Senthilkumar, Narendra Wala, Sharmila Rajendrababu, Chitaranjan Mishra, Naresh Babu Kannan, Mohammed Sithiq Uduman","doi":"10.1080/08820538.2024.2323117","DOIUrl":"https://doi.org/10.1080/08820538.2024.2323117","url":null,"abstract":"To describe the clinical presentation and treatment outcomes of pupillary block glaucoma (PBG) following vitreoretinal surgery (VR surgery).Retrospective observational study of 6941 patients, who u...","PeriodicalId":21702,"journal":{"name":"Seminars in Ophthalmology","volume":null,"pages":null},"PeriodicalIF":1.7,"publicationDate":"2024-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140045110","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}