首页 > 最新文献

Scripta Scientifica Medica最新文献

英文 中文
The application of virtual reality simulators in laparoscopic surgery training (a review) 虚拟现实模拟器在腹腔镜手术训练中的应用(综述)
Pub Date : 2021-12-14 DOI: 10.14748/ssm.v0i0.8079
T. Kalinov, A. Zlatarov, Mehmed Hadzhiveli
{"title":"The application of virtual reality simulators in laparoscopic surgery training (a review)","authors":"T. Kalinov, A. Zlatarov, Mehmed Hadzhiveli","doi":"10.14748/ssm.v0i0.8079","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.8079","url":null,"abstract":"","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76528640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Network-constrained regularization in computational biology and medicine 计算生物学和医学中的网络约束正则化
Pub Date : 2021-12-06 DOI: 10.14748/ssm.v0i0.7762
S. Daskalov, K. Bliznakova
{"title":"Network-constrained regularization in computational biology and medicine","authors":"S. Daskalov, K. Bliznakova","doi":"10.14748/ssm.v0i0.7762","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7762","url":null,"abstract":"","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-12-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80896590","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Postmenopausal bone health may be influenced by the presence of arterial hypertension and antihypertensive therapy 绝经后的骨健康可能受到动脉高血压和抗高血压治疗的影响
Pub Date : 2021-10-21 DOI: 10.14748/SSM.V0I0.7841
R. Dimitrova, K. Hristozov, M. Boyadzhieva
Introduction:  Despite available evidence for a link between bone health and arterial hypertension (AH), the results of clinical trials remain conflicting. Thus, we conducted a cross-sectional study to analyze a possible association between blood pressure (BP), antihypertensive therapy and deteriorating bone health in postmenopausal women.  Materials and Methods:  The study included 84 women from Northeastern Bulgaria. Their mean age was 60.54 ± 7.07 years, and their mean duration of menopause was 11.45 ± 6.62 years. Bone health was assessed by dual-energy X-ray absorptiometry (DEXA) and by analysis of bone metabolic markers.  Results:  A significant negative correlation was established between bone mineral density (BMD) and diastolic BP. On the other hand, AH predominated in the studied population. However, among the subjects diagnosed with osteopenia and osteoporosis, a significantly higher proportion of AH was observed. In addition, differences were found according to the stage of AH and according to the intake of antihypertensive therapy, when assessing BMD and fracture risk. In subjects with newly diagnosed and respectively untreated AH as well as in the group of stage III AH, the lowest BMD and the highest fracture risk were found. Although we reported a significant difference in the mean age of women according to the presence of AH and its stages, after further analysis it was found that the presence of AH is an independent risk factor for bone health in postmenopausal women (OR = 2.14 (0.686–6.703); p = 0.015).  Conclusion:  According to the obtained results, we assumed that AH was risk factor for bone health in postmenopausal women, as it was associated with lower BMD and higher fracture risk. In addition, we found differences according to the stage of AH and antihypertensive therapy, which might be considered in the prevention, prophylaxis and treatment of osteoporosis.
尽管已有证据表明骨骼健康与动脉高血压(AH)之间存在联系,但临床试验的结果仍然相互矛盾。因此,我们进行了一项横断面研究,以分析绝经后妇女血压(BP)、降压治疗与骨质健康恶化之间可能存在的关联。材料和方法:该研究包括来自保加利亚东北部的84名妇女。平均年龄为60.54±7.07岁,平均绝经时间为11.45±6.62岁。通过双能x线吸收仪(DEXA)和骨代谢标志物分析来评估骨骼健康。结果:骨密度(BMD)与舒张压呈显著负相关。另一方面,AH在研究人群中占主导地位。然而,在被诊断为骨质减少和骨质疏松的受试者中,AH的比例明显更高。此外,在评估骨密度和骨折风险时,根据AH分期和抗高血压治疗的摄入量也存在差异。在新诊断AH和未治疗AH以及III期AH组中,骨密度最低,骨折风险最高。虽然我们报道了根据AH的存在及其分期,女性的平均年龄有显著差异,但经过进一步分析发现AH的存在是绝经后妇女骨骼健康的独立危险因素(OR = 2.14 (0.686-6.703);P = 0.015)。结论:根据得到的结果,我们认为AH是绝经后妇女骨骼健康的危险因素,因为它与较低的骨密度和较高的骨折风险相关。此外,我们发现不同的AH分期和抗高血压治疗存在差异,这在骨质疏松症的预防、预防和治疗中可予以考虑。
{"title":"Postmenopausal bone health may be influenced by the presence of arterial hypertension and antihypertensive therapy","authors":"R. Dimitrova, K. Hristozov, M. Boyadzhieva","doi":"10.14748/SSM.V0I0.7841","DOIUrl":"https://doi.org/10.14748/SSM.V0I0.7841","url":null,"abstract":"Introduction:  Despite available evidence for a link between bone health and arterial hypertension (AH), the results of clinical trials remain conflicting. Thus, we conducted a cross-sectional study to analyze a possible association between blood pressure (BP), antihypertensive therapy and deteriorating bone health in postmenopausal women.  Materials and Methods:  The study included 84 women from Northeastern Bulgaria. Their mean age was 60.54 ± 7.07 years, and their mean duration of menopause was 11.45 ± 6.62 years. Bone health was assessed by dual-energy X-ray absorptiometry (DEXA) and by analysis of bone metabolic markers.  Results:  A significant negative correlation was established between bone mineral density (BMD) and diastolic BP. On the other hand, AH predominated in the studied population. However, among the subjects diagnosed with osteopenia and osteoporosis, a significantly higher proportion of AH was observed. In addition, differences were found according to the stage of AH and according to the intake of antihypertensive therapy, when assessing BMD and fracture risk. In subjects with newly diagnosed and respectively untreated AH as well as in the group of stage III AH, the lowest BMD and the highest fracture risk were found. Although we reported a significant difference in the mean age of women according to the presence of AH and its stages, after further analysis it was found that the presence of AH is an independent risk factor for bone health in postmenopausal women (OR = 2.14 (0.686–6.703); p = 0.015).  Conclusion:  According to the obtained results, we assumed that AH was risk factor for bone health in postmenopausal women, as it was associated with lower BMD and higher fracture risk. In addition, we found differences according to the stage of AH and antihypertensive therapy, which might be considered in the prevention, prophylaxis and treatment of osteoporosis.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-10-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77062331","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Surgical rehabilitation of nasal septum perforation in children 儿童鼻中隔穿孔的手术康复
Pub Date : 2021-09-09 DOI: 10.14748/ssm.v53i2.7998
Adnan Yunusov, Nikolai Daykhes, Hassan Diab, Ekaterina Molodtsova
INTRODUCTION: Technical difficulties and failures are also determined by the fact that it is extremely rare to close the perforation by simple mutual displacement and cross-linking of the flaps of mucoperichondrium. The aim of this article is to develop optimal methods for plastic closure of septum perforations in children based on a retrospective analysis of results of surgical treatment. MATERIALS AND METHODS: Plastic surgery closure of septum perforations using a newly developed method is described for 14 patients aged 6–15 years. DISCUSSION: An analysis of the etiological factors affecting disease development is carried out, and the authors’ technique of closing the subtotal perforations is described in detail, adapted for the child’s age, and for preoperative preparation and postoperative management. In all operated patients, the postoperative pe-riod proceeded smoothly, without complications associated with the operation. A follow-up observation for more than a year after surgery showed no recurrence of septal perforation in patients from both groups. CONCLUSION: A careful analysis of the causes, clinical manifestations, localization and sizes of septum perforation in comparison with the anatomical dimensions of intranasal structures allows one to individually select the optimal surgical method.
简介:技术上的困难和失败也取决于这样一个事实,即通过简单的相互位移和粘骨膜瓣的交联来关闭穿孔是极其罕见的。本文的目的是在回顾性分析手术治疗结果的基础上,开发儿童鼻中隔穿孔塑料封闭的最佳方法。材料和方法:采用一种新开发的方法对14例6-15岁的患者进行了鼻中隔穿孔的整形手术。讨论:对影响疾病发展的病因因素进行了分析,并详细描述了作者针对儿童年龄、术前准备和术后处理所采用的缝合次全穿孔的技术。所有手术患者术后顺利,无手术相关并发症。术后随访观察一年多,两组患者均无鼻中隔穿孔复发。结论:仔细分析鼻中隔穿孔的原因、临床表现、定位和大小,并与鼻内结构的解剖尺寸进行比较,可以单独选择最佳的手术方法。
{"title":"Surgical rehabilitation of nasal septum perforation in children","authors":"Adnan Yunusov, Nikolai Daykhes, Hassan Diab, Ekaterina Molodtsova","doi":"10.14748/ssm.v53i2.7998","DOIUrl":"https://doi.org/10.14748/ssm.v53i2.7998","url":null,"abstract":"INTRODUCTION: Technical difficulties and failures are also determined by the fact that it is extremely rare to close the perforation by simple mutual displacement and cross-linking of the flaps of mucoperichondrium. The aim of this article is to develop optimal methods for plastic closure of septum perforations in children based on a retrospective analysis of results of surgical treatment. MATERIALS AND METHODS: Plastic surgery closure of septum perforations using a newly developed method is described for 14 patients aged 6–15 years. DISCUSSION: An analysis of the etiological factors affecting disease development is carried out, and the authors’ technique of closing the subtotal perforations is described in detail, adapted for the child’s age, and for preoperative preparation and postoperative management. In all operated patients, the postoperative pe-riod proceeded smoothly, without complications associated with the operation. A follow-up observation for more than a year after surgery showed no recurrence of septal perforation in patients from both groups. CONCLUSION: A careful analysis of the causes, clinical manifestations, localization and sizes of septum perforation in comparison with the anatomical dimensions of intranasal structures allows one to individually select the optimal surgical method.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82614268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 1
Urinary neutrophil gelatinase-associated lipocalin—an early biomarker for renal injury in patients with beta-thalassemia major 尿中性粒细胞明胶酶相关脂钙素-重度β -地中海贫血患者肾损伤的早期生物标志物
Pub Date : 2021-09-09 DOI: 10.14748/ssm.v53i3.7378
L. Stoyanova, Triphon G Chervenkov
INTRODUCTION : The iron overload and the development of secondary hemosiderosis in patients with β-thalassemia major (β-TM) lead to organ damages, including kidney disorders from early childhood. Contemporary urinary markers such as neutrophil gelatinase-association lipocalin (NGAL), β2-microglobulin (β2-MG), and N-acetyl-β-D-glucosaminidase (NAG) could be a useful tool for clinicians in diagnosis of early tubular lesions. AIM : The aim of this article is to make an assessment of contemporary urine biomarkers β2-microglobulin, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase in the diagnosis of early renal injury in patients with β-TM. MATERIALS AND METHODS : The current study was conducted by examining 44 patients with β-thalassemia major and 30 controls. All participants were tested for NGAL, β2-MG, and NAG in the first sample morning urine using ELISA method. RESULTS : The results show statistically significant differences between the two examined groups in urinary NGAL. CONCLUSION : Urinary NGAL indicates subclinical kidney injury when the tubular reabsorption of molecules is impaired.
导言:β-地中海贫血(β-TM)患者的铁超载和继发性含铁血黄素沉着导致器官损害,包括儿童早期肾脏疾病。当代尿液标志物如中性粒细胞明胶酶相关脂钙蛋白(NGAL)、β2-微球蛋白(β2-MG)和n -乙酰-β- d -氨基葡萄糖苷酶(NAG)可能是临床医生诊断早期肾小管病变的有用工具。目的:评价当代尿液生物标志物β2-微球蛋白、中性粒细胞明胶酶相关脂钙蛋白和n -乙酰- β- d -氨基葡萄糖苷酶在β-TM患者早期肾损伤诊断中的价值。材料和方法:目前的研究是通过检查44例β-地中海贫血患者和30例对照进行的。采用ELISA法检测首次晨尿中NGAL、β2-MG和NAG的含量。结果:两组尿NGAL差异有统计学意义。结论:尿NGAL提示亚临床肾损伤,小管重吸收受损。
{"title":"Urinary neutrophil gelatinase-associated lipocalin—an early biomarker for renal injury in patients with beta-thalassemia major","authors":"L. Stoyanova, Triphon G Chervenkov","doi":"10.14748/ssm.v53i3.7378","DOIUrl":"https://doi.org/10.14748/ssm.v53i3.7378","url":null,"abstract":"INTRODUCTION : The iron overload and the development of secondary hemosiderosis in patients with β-thalassemia major (β-TM) lead to organ damages, including kidney disorders from early childhood. Contemporary urinary markers such as neutrophil gelatinase-association lipocalin (NGAL), β2-microglobulin (β2-MG), and N-acetyl-β-D-glucosaminidase (NAG) could be a useful tool for clinicians in diagnosis of early tubular lesions. AIM : The aim of this article is to make an assessment of contemporary urine biomarkers β2-microglobulin, neutrophil gelatinase-associated lipocalin, and N-acetyl-beta-D-glucosaminidase in the diagnosis of early renal injury in patients with β-TM. MATERIALS AND METHODS : The current study was conducted by examining 44 patients with β-thalassemia major and 30 controls. All participants were tested for NGAL, β2-MG, and NAG in the first sample morning urine using ELISA method. RESULTS : The results show statistically significant differences between the two examined groups in urinary NGAL. CONCLUSION : Urinary NGAL indicates subclinical kidney injury when the tubular reabsorption of molecules is impaired.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"72547021","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Usher syndrome—the most common reason for deaf-blindness Usher综合征——导致耳聋失明的最常见原因
Pub Date : 2021-09-08 DOI: 10.14748/ssm.v0i0.7997
C. Bommert, E. Hristova, C. Grupcheva
Deaf-blindness is a serious disability, which affects all aspects of life. The most common condition combining deafness and blindness is the Usher syndrome (USH), which is traditionally divided into three major clinical subtypes, including Usher syndrome type 1, Usher syndrome type 2, and Usher syndrome type 3. The frequency of USH occurrence is often undervalued. To date, five genes for USH1 have been identified, three genes are involved in USH2, and one gene in USH3. In summary, USH can be a multisensory impairment associated with hearing impairment, progressive retinal degeneration, and vestibular dysfunction. Management of these patients requires interdisciplinary approach and collaboration.
聋盲是一种严重的残疾,影响生活的方方面面。最常见的聋盲结合病症是Usher综合征(USH),传统上将其分为3大临床亚型,包括Usher综合征1型、Usher综合征2型和Usher综合征3型。USH的发生频率经常被低估。迄今为止,已鉴定出5个USH1基因,3个参与USH2基因,1个参与USH3基因。总之,USH可能是一种与听力障碍、进行性视网膜变性和前庭功能障碍相关的多感觉障碍。这些患者的管理需要跨学科的方法和合作。
{"title":"Usher syndrome—the most common reason for deaf-blindness","authors":"C. Bommert, E. Hristova, C. Grupcheva","doi":"10.14748/ssm.v0i0.7997","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7997","url":null,"abstract":"Deaf-blindness is a serious disability, which affects all aspects of life. The most common condition combining deafness and blindness is the Usher syndrome (USH), which is traditionally divided into three major clinical subtypes, including Usher syndrome type 1, Usher syndrome type 2, and Usher syndrome type 3. The frequency of USH occurrence is often undervalued. To date, five genes for USH1 have been identified, three genes are involved in USH2, and one gene in USH3. In summary, USH can be a multisensory impairment associated with hearing impairment, progressive retinal degeneration, and vestibular dysfunction. Management of these patients requires interdisciplinary approach and collaboration.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90899893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in the diagnosis of some common vestibular disorders 一些常见前庭疾病诊断的最新进展
Pub Date : 2021-09-07 DOI: 10.14748/ssm.v0i0.7999
M. Milkov
The interest in the diagnosis of common vestibular disorders in children and adults is permanently increas-ing. In this survey, the applications of the main diagnostic methods in this interdisciplinary field are briefly discussed. The diagnostic capacities of the caloric test, video head impulse test, cervical and ocular vestibular evoked myogenic potentials, videonystagmography, electrococheography, magnetic resonance imaging, computed tomography, etc. are summarized. Special attention is paid to some common vestibular disorders such as Menière’s disease, benign paroxysmal positional vertigo, vestibular migraine, vestibular neuritis, and acute vestibular syndrome. United international efforts will contribute to further improvement of the diagnosis of the vestibular disorders, which warrants their adequate treatment. discuss
对儿童和成人常见前庭疾病诊断的兴趣正在不断增加。本文简要讨论了主要诊断方法在这一跨学科领域的应用。综述了热试验、视频头脉冲试验、颈、眼前庭诱发肌源电位、视频震图、超声、磁共振成像、计算机断层扫描等的诊断能力。特别注意一些常见的前庭疾病,如meni病、良性阵发性位置性眩晕、前庭偏头痛、前庭神经炎和急性前庭综合征。国际上的联合努力将有助于进一步改善前庭疾病的诊断,这需要对其进行适当的治疗。讨论
{"title":"Recent advances in the diagnosis of some common vestibular disorders","authors":"M. Milkov","doi":"10.14748/ssm.v0i0.7999","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7999","url":null,"abstract":"The interest in the diagnosis of common vestibular disorders in children and adults is permanently increas-ing. In this survey, the applications of the main diagnostic methods in this interdisciplinary field are briefly discussed. The diagnostic capacities of the caloric test, video head impulse test, cervical and ocular vestibular evoked myogenic potentials, videonystagmography, electrococheography, magnetic resonance imaging, computed tomography, etc. are summarized. Special attention is paid to some common vestibular disorders such as Menière’s disease, benign paroxysmal positional vertigo, vestibular migraine, vestibular neuritis, and acute vestibular syndrome. United international efforts will contribute to further improvement of the diagnosis of the vestibular disorders, which warrants their adequate treatment. discuss","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78315782","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent graft materials in experimental study stage used in the treatment of nasal septum perforation: a review 近期处于实验研究阶段的移植材料在鼻中隔穿孔治疗中的应用综述
Pub Date : 2021-07-20 DOI: 10.14748/SSM.V0I0.7855
Serdal Çelik, Y. Gunduz, M. Kalcıoğlu
Various conservative approaches are being used for the treatment of nasal septum perforations (NSPs); however, for permanent results, it is essential to use surgical methods. For this purpose, many various surgical methods have been tried, but a satisfactory method has not yet been determined. In order to eliminate the commonly encountered failure of surgical methods, new graft materials combined with flaps have been tried recently and successful results have been reported. In this review, we examined the scientific literature using Medline, PubMed, and Google by using the keywords "nasal septum perforation", "animal study", and "graft". According to the results obtained, we compiled graft materials that have been used in experimental stage related to this subject and reported to have achieved successful results, especially when combined with flaps. These materials seem promising for the successful closure of the hard-to-treat NSPs.
各种保守入路被用于治疗鼻中隔穿孔(NSPs);然而,对于永久性的结果,使用手术方法是必不可少的。为此,人们尝试了许多不同的手术方法,但尚未确定一种令人满意的方法。为了消除手术方法中常见的失败,近年来尝试了新型移植材料与皮瓣结合的方法,并取得了成功的结果。在这篇综述中,我们使用关键词“鼻中隔穿孔”、“动物研究”和“移植”,通过Medline、PubMed和Google查阅了科学文献。根据所获得的结果,我们整理了与本课题相关的已在实验阶段使用并报道取得成功结果的移植物材料,特别是与皮瓣结合使用时。这些材料似乎有望成功关闭难以治疗的nsp。
{"title":"Recent graft materials in experimental study stage used in the treatment of nasal septum perforation: a review","authors":"Serdal Çelik, Y. Gunduz, M. Kalcıoğlu","doi":"10.14748/SSM.V0I0.7855","DOIUrl":"https://doi.org/10.14748/SSM.V0I0.7855","url":null,"abstract":"Various conservative approaches are being used for the treatment of nasal septum perforations (NSPs); however, for permanent results, it is essential to use surgical methods. For this purpose, many various surgical methods have been tried, but a satisfactory method has not yet been determined. In order to eliminate the commonly encountered failure of surgical methods, new graft materials combined with flaps have been tried recently and successful results have been reported. In this review, we examined the scientific literature using Medline, PubMed, and Google by using the keywords \"nasal septum perforation\", \"animal study\", and \"graft\". According to the results obtained, we compiled graft materials that have been used in experimental stage related to this subject and reported to have achieved successful results, especially when combined with flaps. These materials seem promising for the successful closure of the hard-to-treat NSPs.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90600196","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Principles of surgical treatment of chronic post-intubation laryngotracheal stenosis in childhood 儿童慢性插管后喉气管狭窄的手术治疗原则
Pub Date : 2021-07-14 DOI: 10.14748/ssm.v0i0.7854
V. Vavin, I. Nazhmudinov, T. Garashchenko, D. Polyakov, K. Magomedova
Introduction: Post-intubation stenosis of the larynx and trachea in childhood increases annually. This is associated with an increasing number of children with severe pathology of the upper respiratory tract, as well as children requiring artificial ventilation for other reasons. Until now there have been debatable questions about surgical tactics in children with chronic cicatricial laryngeal stenosis. Aim: The aim of this article is to evaluate the effectiveness of different tactics of surgical treatment of children with chronic cicatricial post-intubation stenosis of the larynx, depending on the state of the cartilaginous frame of the larynx. Materials and Methods: We have treated 47 children with chronic cicatricial post-intubation stenosis of the larynx. Preoperative examination included endoscopy and computed tomography of the larynx and trachea. We assessed the cartilaginous framework of the larynx and trachea that influenced the choice of surgical approach. For 20 children with intact laryngeal cartilaginous frame the method of endolaryngeal microsurgery using a CO2 laser was applied. This method allowed to form a wound surface by minimum submucosal resection scar tissue, which made it possible to cover the wound with mucosal microflaps to prevent restenosis. In the surgical treatment of extended stenoses of the middle larynx, there are prerequisites for repeated replacement of the wound with excess scar tissue, which in our observations was avoided by using endoprostheses for a period of 21 days. Despite it, with a lesion of the subglottic part of the larynx, the risk of restenosis remained quite high (5 out of 12 patients), even in the absence of data for damage to the cartilaginous frame of the larynx. In 27 cases of chronic post-intubation cicatricial stenosis of the larynx, in identifying of laryngeal cartilage framework lesion before surgery, extralaryngeal laryngotracheoplasty was performed. Laryngofissure was performed in 18 children, followed by stenting from 6 to 18 months with a T-shaped silicone stent, in 9 cases—one-stage laryngotracheoplasty using auto-cartilage grafts. The applied techniques have shown high efficiency, while the use of autografts made it possible to reduce the stages and duration of surgical treatment. Conclusion: The use of a CO2 laser in combination with balloon laryngoplasty in microsurgical treatment of chronic post-intubation stenosis of the larynx in children significantly expands surgical capabilities due to high accuracy and low level of damage of surrounding tissues.
儿童插管后喉和气管狭窄逐年增加。这与越来越多患有严重上呼吸道病理的儿童以及因其他原因需要人工通气的儿童有关。到目前为止,关于儿童慢性瘢痕性喉狭窄的手术策略一直存在争议。目的:本文的目的是评估不同策略的手术治疗儿童慢性瘢痕性插管后喉狭窄的有效性,这取决于喉软骨框架的状态。材料与方法:我们治疗47例慢性瘢痕性插管后喉狭窄患儿。术前检查包括喉部和气管的内窥镜检查和计算机断层扫描。我们评估了影响手术入路选择的喉部和气管软骨框架。对20例喉软骨架完整的患儿,采用CO2激光咽内显微手术治疗。这种方法允许通过最小的粘膜下切除瘢痕组织形成创面,这使得用粘膜微瓣覆盖创面以防止再狭窄成为可能。在中喉扩张性狭窄的手术治疗中,有必要用多余的瘢痕组织反复替换伤口,在我们的观察中,使用人工人工体21天避免了这种情况。尽管如此,在喉声门下部分病变的情况下,再狭窄的风险仍然很高(12例患者中有5例),即使没有关于喉软骨框架损伤的数据。对27例慢性气管插管后瘢痕性喉狭窄患者,术前识别喉软骨框架病变,行咽外喉气管成形术。18例患儿行喉裂手术,术后6 ~ 18个月行t型硅胶支架植入术,其中9例采用自体软骨一期喉气管成形术。应用的技术已经显示出高效率,而自体移植物的使用可以减少手术治疗的阶段和持续时间。结论:CO2激光联合球囊喉成形术显微外科治疗儿童气管插管后慢性喉狭窄,准确性高,对周围组织损伤程度低,显著扩大手术能力。
{"title":"Principles of surgical treatment of chronic post-intubation laryngotracheal stenosis in childhood","authors":"V. Vavin, I. Nazhmudinov, T. Garashchenko, D. Polyakov, K. Magomedova","doi":"10.14748/ssm.v0i0.7854","DOIUrl":"https://doi.org/10.14748/ssm.v0i0.7854","url":null,"abstract":"Introduction: Post-intubation stenosis of the larynx and trachea in childhood increases annually. This is associated with an increasing number of children with severe pathology of the upper respiratory tract, as well as children requiring artificial ventilation for other reasons. Until now there have been debatable questions about surgical tactics in children with chronic cicatricial laryngeal stenosis. Aim: The aim of this article is to evaluate the effectiveness of different tactics of surgical treatment of children with chronic cicatricial post-intubation stenosis of the larynx, depending on the state of the cartilaginous frame of the larynx. Materials and Methods: We have treated 47 children with chronic cicatricial post-intubation stenosis of the larynx. Preoperative examination included endoscopy and computed tomography of the larynx and trachea. We assessed the cartilaginous framework of the larynx and trachea that influenced the choice of surgical approach. For 20 children with intact laryngeal cartilaginous frame the method of endolaryngeal microsurgery using a CO2 laser was applied. This method allowed to form a wound surface by minimum submucosal resection scar tissue, which made it possible to cover the wound with mucosal microflaps to prevent restenosis. In the surgical treatment of extended stenoses of the middle larynx, there are prerequisites for repeated replacement of the wound with excess scar tissue, which in our observations was avoided by using endoprostheses for a period of 21 days. Despite it, with a lesion of the subglottic part of the larynx, the risk of restenosis remained quite high (5 out of 12 patients), even in the absence of data for damage to the cartilaginous frame of the larynx. In 27 cases of chronic post-intubation cicatricial stenosis of the larynx, in identifying of laryngeal cartilage framework lesion before surgery, extralaryngeal laryngotracheoplasty was performed. Laryngofissure was performed in 18 children, followed by stenting from 6 to 18 months with a T-shaped silicone stent, in 9 cases—one-stage laryngotracheoplasty using auto-cartilage grafts. The applied techniques have shown high efficiency, while the use of autografts made it possible to reduce the stages and duration of surgical treatment. Conclusion: The use of a CO2 laser in combination with balloon laryngoplasty in microsurgical treatment of chronic post-intubation stenosis of the larynx in children significantly expands surgical capabilities due to high accuracy and low level of damage of surrounding tissues.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82307229","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Aural polyps: What's behind them? 耳息肉:它们背后是什么?
Pub Date : 2021-07-13 DOI: 10.14748/SSM.V0I0.7850
Alice Lang Silva, F. Selaimen, Isabel Conte, Marcela Lehmkuhl Damiani, Luciana Lima Martins Costa, L. Rosito, S. S. Costa
Introduction: Polyps in the external auditory canal (EAC) may be present due to inflammation induced by chronic otitis media. In many cases, the type of underlying otitis media is a cholesteatoma. Aim: The aim of this article is to determine the etiology of EAC polyps in patients referred to the Otology Division of a tertiary hospital in south Brazil. Materials and Methods: Cross-sectional study was conducted with a cohort of patients with otologic diseases who were evaluated from July 2001 to December 2020. Patients with unilateral or bilateral aural polyps underwent anamnesis and recorded video-otoscopy and had their online medical chart reviewed. Results:  Of the 2432 patients evaluated, 133 (5.4%) had a polyp in the external auditory canal. Of those, 53 were excluded, leaving a final sample of 81 patients (3.3%). Discussion:  Middle ear cholesteatoma (MEC) and non-cholesteatomatous chronic otitis media (NCCOM) were responsible for 86.3% of all polyps evaluated and the majority of diagnoses were established through surgery (76.5%). Conclusion: Symptoms associated with polyps and their aspect do not reveal the most probable etiologies making imaging exams, biopsy and surgery necessary steps in aural polyp investigation.
外耳道息肉可能是由慢性中耳炎引起的炎症引起的。在许多情况下,潜在中耳炎的类型是胆脂瘤。目的:这篇文章的目的是确定EAC息肉的病因在病人转诊耳科在巴西南部的三级医院。材料和方法:对2001年7月至2020年12月评估的耳科疾病患者进行横断面研究。对单侧或双侧耳部息肉患者进行记忆和视频耳镜检查,并对其在线病历进行审查。结果:在2432例患者中,133例(5.4%)外耳道息肉。其中53例被排除,最终样本为81例(3.3%)。讨论:中耳胆脂瘤(MEC)和非胆脂瘤性慢性中耳炎(NCCOM)占所有评估息肉的86.3%,大多数诊断是通过手术确定的(76.5%)。结论:与息肉相关的症状及其表现不能揭示最可能的病因,因此影像学检查、活检和手术是诊断耳部息肉的必要步骤。
{"title":"Aural polyps: What's behind them?","authors":"Alice Lang Silva, F. Selaimen, Isabel Conte, Marcela Lehmkuhl Damiani, Luciana Lima Martins Costa, L. Rosito, S. S. Costa","doi":"10.14748/SSM.V0I0.7850","DOIUrl":"https://doi.org/10.14748/SSM.V0I0.7850","url":null,"abstract":"Introduction: Polyps in the external auditory canal (EAC) may be present due to inflammation induced by chronic otitis media. In many cases, the type of underlying otitis media is a cholesteatoma. Aim: The aim of this article is to determine the etiology of EAC polyps in patients referred to the Otology Division of a tertiary hospital in south Brazil. Materials and Methods: Cross-sectional study was conducted with a cohort of patients with otologic diseases who were evaluated from July 2001 to December 2020. Patients with unilateral or bilateral aural polyps underwent anamnesis and recorded video-otoscopy and had their online medical chart reviewed. Results:  Of the 2432 patients evaluated, 133 (5.4%) had a polyp in the external auditory canal. Of those, 53 were excluded, leaving a final sample of 81 patients (3.3%). Discussion:  Middle ear cholesteatoma (MEC) and non-cholesteatomatous chronic otitis media (NCCOM) were responsible for 86.3% of all polyps evaluated and the majority of diagnoses were established through surgery (76.5%). Conclusion: Symptoms associated with polyps and their aspect do not reveal the most probable etiologies making imaging exams, biopsy and surgery necessary steps in aural polyp investigation.","PeriodicalId":21710,"journal":{"name":"Scripta Scientifica Medica","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-07-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81746880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Scripta Scientifica Medica
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1