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Food effect on pharmacokinetic profiles of sildenafil 100 mg oral films in healthy male volunteers: results from two randomized, single dose, crossover studies. 食物对健康男性志愿者100mg西地那非口服片药代动力学的影响:两项随机、单剂量、交叉研究的结果
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-23 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf096
Quan Minh Pham, Dimitri Yannas, Andrea Sansone, Javier Romero-Otero, Pedro Vendeira, Valeria Frangione, Emmanuele A Jannini
<p><strong>Background: </strong>Decades after it was first put on the market, sildenafil is still a very successful treatment for erectile dysfunction. New formulations, such orodispersible films (ODFs), offer more convenience allowing more discreet use and enabling people who might have trouble swallowing tablets to take the drug.</p><p><strong>Aim: </strong>To evaluate the impact of food and water on sildenafil ODF as compared to sildenafil film-coated tablet (FCT) and to assess the safety and palatability of the orodispersible formulation.</p><p><strong>Methods: </strong>Two randomized, single-dose, three-period, crossover studies were conducted on healthy male volunteers. The first study, involving 45 subjects, was designed to compare ODF versus FCT under fasting conditions and to study the effect of high-fat, high-calorie meal on ODF pharmacokinetic (PK) profiles. The second study, involving 35 subjects, compared ODF versus FCT under fed conditions and the effect of water on ODF PK profiles. Blood samples were collected within 24 h post-dosing to measure plasma sildenafil and its metabolite, <i>N</i>-desmethyl-sildenafil.</p><p><strong>Outcomes: </strong>Primary outcomes were maximum observed plasma concentration (<i>C</i> <sub>max</sub>), the area under the concentration-time curve (AUC), and the time of maximum observed plasma concentration (<i>T</i> <sub>max</sub>). Secondary outcomes included palatability and safety.</p><p><strong>Results: </strong>Food delayed sildenafil 100 mg ODF <i>T</i> <sub>max</sub> by 1.45 h and decreased <i>C</i> <sub>max</sub> by 45% but did not affect the extent of systemic exposure to sildenafil (AUC). Bioequivalence was demonstrated for sildenafil ODF administered with and without water under fed conditions. <i>C</i> <sub>max</sub> of plasma sildenafil was ~13% and 17% lower for ODF (without and with water, respectively), and <i>T</i> <sub>max</sub> was delayed by 1-1.5 h, compared to FCT under fed conditions, but both AUC<sub>0-t</sub> and AUC<sub>0-∞</sub> met the bioequivalence limits. Palatability was acceptable with mild aftertastes. The ODF formulation was well-tolerated with no severe adverse events.</p><p><strong>Clinical implications: </strong>Sildenafil ODF is a bioequivalent alternative to traditional tablets. The food impact on sildenafil ODF taken with and without water is consistent with that associated with FCT, influencing <i>C</i> <sub>max</sub> and <i>T</i> <sub>max</sub> but not AUC.</p><p><strong>Strengths and limitations: </strong>The study population consisted exclusively of healthy subjects, and the study was limited to single-dose administration. Lastly, although bioequivalence of PKs implies therapeutic equivalence, future studies incorporating clinical endpoints would offer more conclusive evidence of interchangeability.</p><p><strong>Conclusion: </strong>Sildenafil ODF has comparable PKs and added convenience for patients. Its versatility, ease of use, and discreetness make it idea
背景:在西地那非首次上市几十年后,它仍然是一种非常成功的治疗勃起功能障碍的药物。新的配方,如可分散薄膜(odf),提供了更多的方便,允许更谨慎的使用,并使那些可能吞咽药片有困难的人服用药物。目的:比较食物和水对西地那非薄膜包衣片(FCT)的影响,评价其体外分散制剂的安全性和食性。方法:对健康男性志愿者进行两项随机、单剂量、三期交叉研究。第一项研究涉及45名受试者,旨在比较禁食条件下的ODF和FCT,并研究高脂肪、高热量膳食对ODF药代动力学(PK)谱的影响。第二项研究涉及35名受试者,比较了在饲喂条件下ODF和FCT以及水分对ODF PK谱的影响。给药后24小时内采集血样,测定血浆中西地那非及其代谢物n -去甲基西地那非的含量。结果:主要结果为最大观察血浆浓度(cmax)、浓度-时间曲线下面积(AUC)和最大观察血浆浓度时间(tmax)。次要结果包括适口性和安全性。结果:食物使西地那非100 mg ODF tmax延迟1.45 h,使cmax降低45%,但不影响西地那非全身暴露程度(AUC)。生物等效性证明了西地那非ODF在喂养条件下有水和无水给药。ODF组(无水组和加水组)血浆西地那非的cmax比饲料条件下低13%和17%,tmax比饲料条件下延迟1 ~ 1.5 h,但AUC0- T和AUC0-∞均满足生物等效性极限。适口性尚可,回味温和。ODF制剂耐受性良好,无严重不良事件。临床意义:西地那非ODF是传统片剂的生物等效替代品。食物对西地那非ODF在有水和无水情况下的影响与与FCT相关的影响一致,影响最大碳和最大T,但不影响AUC。优势和局限性:研究人群完全由健康受试者组成,研究仅限于单剂量给药。最后,尽管PKs的生物等效性意味着治疗等效,但纳入临床终点的未来研究将提供更确凿的可互换性证据。结论:西地那非ODF具有相当的PKs,并增加了患者的便利性。它的多功能性、易用性和谨慎性使其成为FCT安全有效的理想替代品。ISRCTN注册编号,可访问试验方案:研究A: ISRCTN13297409 (10.1186/ISRCTN13297409)研究B: ISRCTN15394603 (10.1186/ISRCTN15394603)。
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引用次数: 0
Assessing the relationship between sexual health literacy and sexual self-care in women: a cross-sectional study in Iran. 评估妇女性健康素养与性自我保健之间的关系:伊朗的一项横断面研究。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-19 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf071
Fatemeh Darban, Nastaran Heydarikhayat, Sahar Olyaee, Nazanin Raeisi

Background: Sexual self-care behaviors in women play a crucial role in promoting their sexual health, ultimately enhancing family and societal well-being. Adequate knowledge and the ability to apply such information are key factors influencing sexual self-care.

Aim: This study was conducted to examine the relationship between sexual health literacy and sexual self-care among women.

Methods: This cross-sectional study was conducted among 435 women of reproductive age attending healthcare centers affiliated with Iranshahr University of Medical Sciences, Iran, during 2024-2025. Data were collected using validated questionnaires on sexual self-care and the Iranian Adult Sexual Health Literacy scale. Statistical analysis was performed using SPSS 22, employing logistic regression, analysis of variance (ANOVA), and multiple linear regression models.

Outcomes: Determined the relationship between sexual health literacy and sexual self-care in young women.

Results: The results revealed a statistically significant direct association between sexual self-care and sexual health literacy (P = .000). Women demonstrating higher sexual health literacy scores reported higher sexual self-care scores. Sexual self-care was associated with total sexual health literacy scores, as well as with the dimensions of information access skills and information application skills.

Clinical implications: The results provide a rationale for policymakers to implement targeted sexual health literacy programs, which can subsequently enhance self-care practices.

Strengths and limitations: The strengths of this study include the use of robust statistical methods and a large, representative sample size. However, limitations should be noted, such as the dependence on self-reported data, which may introduce bias, and the restricted generalizability of findings due to the single-region, cross-sectional study design.

Conclusion: This study demonstrated that improved sexual health literacy enhances sexual self-care scores in women. These results highlight the crucial need to enhance women's sexual health literacy.

背景:女性的性自我保健行为在促进其性健康,最终增强家庭和社会福祉方面发挥着至关重要的作用。充分的知识和应用这些信息的能力是影响性自我保健的关键因素。目的:探讨女性性健康素养与性自我保健的关系。方法:本横断面研究在2024-2025年期间在伊朗伊朗沙赫尔医科大学附属保健中心就诊的435名育龄妇女中进行。数据收集使用有效的性自我保健问卷和伊朗成人性健康素养量表。采用SPSS 22进行统计分析,采用logistic回归、方差分析(ANOVA)和多元线性回归模型。结果:确定年轻女性性健康素养与性自我保健之间的关系。结果:结果显示,性自我保健与性健康素养之间有统计学意义的直接关联(P = .000)。性健康素养得分较高的妇女报告的性自我保健得分也较高。性自我保健与性健康素养总分、信息获取技能和信息应用技能维度相关。临床意义:研究结果为政策制定者实施有针对性的性健康扫盲计划提供了依据,该计划随后可以加强自我保健实践。优势和局限性:本研究的优势包括使用稳健的统计方法和大的、有代表性的样本量。然而,该研究也存在局限性,例如依赖于自我报告的数据,这可能会引入偏倚,以及由于单区域、横断面研究设计,研究结果的可推广性受到限制。结论:本研究表明,提高性健康素养可以提高女性的性自我保健得分。这些结果突出了提高妇女性健康知识的关键必要性。
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引用次数: 0
Study of psychosocial factors affecting premature ejaculation from the perspective of personality traits: a large sample cross-sectional study from Anhui, China. 人格特质视角下影响早泄的社会心理因素研究:来自安徽的大样本横断面研究。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-15 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf094
Jingjing Gao, Rui Gao, Kun Wang, Guosheng Xu, Zifang Zhang, Xiaodong Bai, Jishuang Liu, Kai Shi, Jun Mao, Yao Zhang, Xiansheng Zhang

Background: Personality traits are the intrinsic factors of mental health, and may play a role in the pathogenesis of premature ejaculation (PE), but few studies have evaluated the association between personality traits and the 4 types of PE.

Aim: We aim to investigate the personality traits associated with PE in 4 types of PE and their associations with PE.

Methods: Between February 2024 and February 2025, we conducted a survey in Anhui, China, and enrolled 1708 males. Personality traits were independently assessed by the Myers-Briggs Type Indicator (MBTI). The index of PE was used to evaluate ejaculation control, sexual life satisfaction, and distress caused by PE.

Outcomes: Energy-Introversion, Perceiving-Sensing, Judging-Feeling, and Orientation-Perception may influence men's sexual activity, and the Energy, Perceiving, and Orientation have different effects on the 4 types of PE.

Results: The ISFP personality type is most common in those with PE. Among the 4 subtypes of PE, the Introversion-Intuition-Feeling-Perceiving (INFP) personality type is most common in those with Lifelong PE (LPE), the Extraversion-Sensing-Feeling-Judging (ESFJ) personality type is most common in those with Acquired PE (APE), the Introversion-Sensing-Feeling-Perceiving (ISFP) personality type is most common in those with Variable PE (VPE), and the Extraversion-Sensing-Feeling-Perceiving (ESFP) personality type is most common in those with Subjective PE (SPE).

Clinical implications: Personality trait factors may influence the pathogenesis of PE, and the use of the MBTI personality assessment provides a new perspective on how personality traits play a role in the onset of PE.

Strengths & limitations: It is necessary to conduct larger-scale, more rigorous community-based studies to further elucidate the role of personality traits in the development of PE.

Conclusion: Men with traits of Introversion, Sensing, Feeling, and Perception tend to have high sensitivity, introspection, and a deep pursuit of idealized relationships.

背景:人格特质是心理健康的内在因素,可能在早泄的发病机制中发挥作用,但很少有研究评估人格特质与四种早泄之间的关系。目的:探讨四种类型体育运动的人格特征及其与体育运动的关系。方法:于2024年2月至2025年2月在中国安徽开展调查,共招募男性1708人。人格特征由迈尔斯-布里格斯类型指标(MBTI)独立评估。PE指标用于评价射精控制、性生活满意度和PE引起的痛苦。结果:能量内倾、知觉-感觉、判断-感觉和取向-感知可能影响男性的性行为,能量、知觉和取向对4种类型的性行为有不同的影响。结果:ISFP型人格类型在PE患者中最为常见。PE的4个亚型中,Introversion-Intuition-Feeling-Perceiving (INFP)人格类型是最常见的在那些与终身体育(简述)的Extraversion-Sensing-Feeling-Judging (ESFJ)人格类型是最常见的在那些收购PE(猿)的Introversion-Sensing-Feeling-Perceiving物性格类型中最常见的那些变量PE(汽相外延)和Extraversion-Sensing-Feeling-Perceiving (ESFP)人格类型是最常见的和主观的PE (SPE)。临床意义:人格特质因素可能影响PE的发病机制,MBTI人格评估的应用为人格特质在PE发病中的作用提供了新的视角。优势与局限:需要进行更大规模、更严谨的社区研究来进一步阐明人格特质在体育发展中的作用。结论:具有内倾、感知、感觉和感知特征的男性往往具有较高的敏感性、自省能力和对理想关系的强烈追求。
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引用次数: 0
Two sides of the same coin? Prevalence and co-occurrence of binge eating disorder and compulsive sexual behavior disorder in a representative sample of the Polish population. 同一枚硬币的两面?波兰人口代表性样本中暴食症和强迫性性行为障碍的患病率和共发率。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-09 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf092
Ewelina Kowalewska, Michał Lew-Starowicz

Background: Although increasingly recognized, research into the prevalence and co-occurrence of binge eating disorder (BED) and compulsive sexual behavior disorder (CSBD) remains scarce.

Aim: To evaluate the prevalence and co-occurrence of BED and CSBD in a representative Polish population while examining their associations with sexual behavior-related variables, and levels of anxiety and depression.

Methods: Data were collected from a representative sample of Polish adults, consisting of 1527 participants aged 18-65.

Outcomes: The occurrence and intersection of symptoms of BED and CSBD.

Results: Men reported significantly higher CSBD symptoms (Z = 9.62, P < .001, d = 0.52) and problematic sexual behaviors, while women reported higher BED (Z = 5.51, P < .001, d = 0.30) and anxiety symptoms (Z = 7.46, P < .001, d = 0.39). BED and CSBD symptoms co-occurred significantly in men (χ 2(1) = 59.00, P < .001), but not in women (χ 2(1) = 1.51, P = .22). BED symptoms were positively correlated with anxiety (r = 0.46, P < .001) and depression (r = 0.47, P < .001), highlighting their interplay with psychological distress.

Clinical implications: Findings underscore shared mechanisms across BED and CSBD, suggesting the potential effectiveness of transdiagnostic treatment approaches addressing co-occurring symptoms, emotional regulation, and impulsivity within a unified therapeutic framework.

Strengths and limitations: Strengths include a representative sample and the examination of underexplored comorbidity patterns. Limitations include the cross-sectional design and reliance on self-report measures, warranting longitudinal and multimethod research for causal inferences.

Conclusion: This study reveals significant gender differences in BED and CSBD symptoms and demonstrates their co-occurrence among men, emphasizing the need for gender-sensitive, integrated clinical approaches to assessment and treatment.

背景:尽管人们越来越认识到暴食症(BED)和强迫性行为障碍(CSBD)的患病率和共发性的研究仍然很少。目的:评估波兰代表性人群中BED和CSBD的患病率和共发率,同时检查其与性行为相关变量以及焦虑和抑郁水平的关系。方法:从波兰成年人的代表性样本中收集数据,包括1527名18-65岁的参与者。结果:BED和CSBD症状的发生和交叉。结果:男性报告的CSBD症状(Z = 9.62, P d = 0.52)和问题性行为显著高于女性(Z = 5.51, P d = 0.30)和焦虑症状(Z = 7.46, P d = 0.39)。男性BED和CSBD症状同时出现(χ 2(1) = 59.00, P χ 2(1) = 1.51, P = 0.22)。临床意义:研究结果强调了BED和CSBD的共同机制,表明在统一的治疗框架内,跨诊断治疗方法解决共同出现的症状、情绪调节和冲动的潜在有效性。优势和局限性:优势包括代表性样本和对未充分探索的合并症模式的检查。局限性包括横断面设计和对自我报告测量的依赖,保证纵向和多方法研究因果推论。结论:本研究揭示了BED和CSBD症状的显著性别差异,并表明它们在男性中同时出现,强调需要对性别敏感、综合的临床方法来评估和治疗。
{"title":"Two sides of the same coin? Prevalence and co-occurrence of binge eating disorder and compulsive sexual behavior disorder in a representative sample of the Polish population.","authors":"Ewelina Kowalewska, Michał Lew-Starowicz","doi":"10.1093/sexmed/qfaf092","DOIUrl":"10.1093/sexmed/qfaf092","url":null,"abstract":"<p><strong>Background: </strong>Although increasingly recognized, research into the prevalence and co-occurrence of binge eating disorder (BED) and compulsive sexual behavior disorder (CSBD) remains scarce.</p><p><strong>Aim: </strong>To evaluate the prevalence and co-occurrence of BED and CSBD in a representative Polish population while examining their associations with sexual behavior-related variables, and levels of anxiety and depression.</p><p><strong>Methods: </strong>Data were collected from a representative sample of Polish adults, consisting of 1527 participants aged 18-65.</p><p><strong>Outcomes: </strong>The occurrence and intersection of symptoms of BED and CSBD.</p><p><strong>Results: </strong>Men reported significantly higher CSBD symptoms (<i>Z</i> = 9.62, <i>P</i> < .001, <i>d</i> = 0.52) and problematic sexual behaviors, while women reported higher BED (<i>Z</i> = 5.51, <i>P</i> < .001, <i>d</i> = 0.30) and anxiety symptoms (<i>Z</i> = 7.46, <i>P</i> < .001, <i>d</i> = 0.39). BED and CSBD symptoms co-occurred significantly in men (<i>χ</i> <sup>2</sup>(1) = 59.00, <i>P</i> < .001), but not in women (<i>χ</i> <sup>2</sup>(1) = 1.51, <i>P</i> = .22). BED symptoms were positively correlated with anxiety (<i>r</i> = 0.46, <i>P</i> < .001) and depression (<i>r</i> = 0.47, <i>P</i> < .001), highlighting their interplay with psychological distress.</p><p><strong>Clinical implications: </strong>Findings underscore shared mechanisms across BED and CSBD, suggesting the potential effectiveness of transdiagnostic treatment approaches addressing co-occurring symptoms, emotional regulation, and impulsivity within a unified therapeutic framework.</p><p><strong>Strengths and limitations: </strong>Strengths include a representative sample and the examination of underexplored comorbidity patterns. Limitations include the cross-sectional design and reliance on self-report measures, warranting longitudinal and multimethod research for causal inferences.</p><p><strong>Conclusion: </strong>This study reveals significant gender differences in BED and CSBD symptoms and demonstrates their co-occurrence among men, emphasizing the need for gender-sensitive, integrated clinical approaches to assessment and treatment.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf092"},"PeriodicalIF":2.0,"publicationDate":"2025-11-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12597027/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145489513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Virtual versus in-person sexual rehabilitation for prostate cancer survivors: a retrospective cohort study comparing the Prostate Cancer Rehabilitation Clinic (PCRC) and the True North Sexual Health and Rehabilitation eClinic (SHAReClinic). 前列腺癌幸存者的虚拟与面对面性康复:一项回顾性队列研究,比较前列腺癌康复诊所(PCRC)和真北性健康与康复诊所(SHAReClinic)。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-06 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf088
Andrew G Matthew, Steven Guirguis, Taylor Incze, Dalia Peres, Richard J Wassersug, Lauren Walker, John W Robinson, Deborah McLeod, Stacy Elliott, Antionio Finelli, Neil Fleshner, Leah Jamnicky, Shiyi Chen, Dean Elterman

Background: Sexual dysfunction is a common and distressing consequence of prostate cancer (PCa) treatment, yet few healthcare institutions offer comprehensive, systematic care, limiting equitable access. Virtual models may improve accessibility and efficiency without sacrificing effectiveness.

Aim: To assess whether outcomes in the virtual Sexual Health and Rehabilitation eClinic (SHAReClinic) were comparable to those in the in-person Prostate Cancer Rehabilitation Clinic (PCRC) in improving sexual health outcomes for PCa survivors.

Methods: A retrospective cohort chart review was conducted on PCa patients enrolled in either the PCRC or SHAReClinic between September 2017 and August 2018, with data collected 12 months post-treatment. Clinic assignment was based on standard care pathways. Sexual health outcomes were measured using the Sexual Health Inventory for Men (SHIM), Sexual Distress Scale (SDS), Male Sexual Health Questionnaire (MSIS), and Expanded Prostate Cancer Index Composite (EPIC-26). Pro-erectile medication usage was also analyzed.

Outcomes: Primary outcomes were SHIM and SDS scores. Secondary outcomes included MSIS, EPIC-26 scores, and pro-erectile medication use as an indicator for adherence and ongoing sexual activity.

Results: Among 98 PCa patients (55 PCRC, 43 SHAReClinic), no significant differences were found in SHIM and SDS scores. While partnered PCRC participants reported significantly higher intimacy on the MSIS compared to partnered SHAReClinic participants (P = .042), no significant differences were found on the EPIC-26 sexual health domain. Pro-erectile medication use was similar in both groups. Multivariable analyses showed comparable outcomes in sexual function, distress, and health-related quality of life, except for intimacy.

Clinical implications: SHAReClinic yields comparable outcomes to PCRC and provides an effective, resource-efficient alternative to in-person sexual rehabilitation for PCa patients, particularly in settings with limited accessibility or resources.

Strengths and limitations: This study provides a comprehensive assessment of sexual health outcomes; however, the small sample size limits generalizability. In addition, there was a significant imbalance in treatment modality, with radiation patients represented only in the SHAReClinic cohort. Further research in larger, more diverse populations with longer follow-up is needed to confirm these findings and better understand intimacy differences.

Conclusion: SHAReClinic demonstrates outcomes comparable to PCRC in managing sexual dysfunction in PCa patients, offering a viable and accessible option for sexual rehabilitation.

背景:性功能障碍是前列腺癌(PCa)治疗的常见和令人痛苦的后果,但很少有医疗机构提供全面,系统的护理,限制了公平获取。虚拟模型可以在不牺牲有效性的情况下提高可访问性和效率。目的:评估虚拟性健康和康复诊所(SHAReClinic)在改善前列腺癌幸存者性健康结果方面是否与面对面的前列腺癌康复诊所(PCRC)相当。方法:对2017年9月至2018年8月在PCRC或SHAReClinic登记的PCa患者进行回顾性队列图回顾,数据收集于治疗后12个月。临床分配基于标准护理途径。采用男性性健康量表(SHIM)、性困扰量表(SDS)、男性性健康问卷(MSIS)和扩展前列腺癌指数综合量表(EPIC-26)对性健康结果进行测量。还分析了促勃起药物的使用情况。结果:主要结果为SHIM和SDS评分。次要结果包括MSIS、EPIC-26评分和促勃起药物使用作为依从性和持续性活动的指标。结果:98例PCa患者(55例PCRC, 43例SHAReClinic), SHIM和SDS评分无显著差异。与SHAReClinic合作的参与者相比,PCRC合作的参与者在MSIS上报告了更高的亲密度(P =。042),在EPIC-26性健康领域没有发现显著差异。两组的促勃起药物使用情况相似。多变量分析显示,除亲密关系外,性功能、痛苦和健康相关生活质量的结果具有可比性。临床意义:SHAReClinic的结果与PCRC相当,并为PCa患者提供了一种有效的、资源高效的替代方案,特别是在可及性或资源有限的环境中。优势和局限性:本研究对性健康结果进行了全面评估;然而,小样本量限制了普遍性。此外,在治疗方式上存在显著的不平衡,仅在SHAReClinic队列中有放疗患者。需要在更大、更多样化的人群中进行进一步的研究,并进行更长时间的随访,以证实这些发现,并更好地了解亲密关系的差异。结论:SHAReClinic在治疗前列腺癌患者的性功能障碍方面显示了与PCRC相当的结果,为性康复提供了一个可行的和可获得的选择。
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引用次数: 0
Factors associated with compulsive sexual behavior in a national probability web-based aged 18-59 years sample from Japan: a cross-sectional survey. 日本18-59岁全国概率网络样本中与强迫性性行为相关的因素:横断面调查。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-11-04 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf091
Yushun Okabe, Daisuke Ito
<p><strong>Background: </strong>Compulsive sexual behavior disorder (CSBD) involves persistent, repetitive sexual behaviors that continue despite efforts to stop, leading to significant distress or impairment in personal, family, social, educational, and occupational functioning. Most compulsive sexual behavior (CSB) research focuses on Western countries, leaving its characteristics in Japan largely unexplored. Although treatment-seeking behavior for CSB is documented in Western contexts, there is a need to understand this behavior in Japan to improve mental health services.</p><p><strong>Aims: </strong>This cross-sectional study aimed to clarify association between CSB, sociodemographic factors, maximum sexual behavior duration, life satisfaction, negative consequences, psychological co-morbidities, and treatment-seeking behaviors in Japan.</p><p><strong>Methods: </strong>Participants were recruited from a national probability-based sample of adults aged 18-59 in Japan using a web-based questionnaire, with proportional representation of sex assigned at birth, age groups, and residential areas. A total of 1094 respondents (43.69% heterosexual cisgender men, <i>M</i> <sub>age</sub> = 39.9 ± 11.6) were included.</p><p><strong>Outcomes: </strong>Participants completed the Compulsive Sexual Behavior Disorder Scale-19 (mean score = 24.35 ± 9.27), reporting sexual behavior frequency, time spent on sexual behaviors, life satisfaction, negative consequences related to sexual behaviors, treatment-seeking behaviors, and comorbid conditions such as depression (Patient Health Questionnaire-9), anxiety (Generalized Anxiety Disorder-7), and Adult Attention-deficit Hyperactivity Disorder (ADHD) (Adult Attention-deficit Hyperactivity Disorder Self-Report Scale).</p><p><strong>Results: </strong>Individuals at high risk of CSBD (<i>n</i> = 28; 2.56%), based on the CSBD-19 cut-off score, were more likely to be cisgender heterosexual men than women (chi-squared test). Compared to low-risk individuals, those at high risk spent more maximum duration on pornography and masturbation, lower life satisfaction in health and intimate relationships, experienced negative consequences in various life domains (eg, sleep, social activities, work, family life, finances, and physical health), and exhibited symptoms of depression, anxiety, and ADHD. Three individuals at high risk of CSBD reported seeking treatment.</p><p><strong>Clinical implications: </strong>Individuals at high risk of CSBD experience negative consequences and psychological co-morbidities, making it critical to investigate contributing factors to provide effective treatment for CSB in Japan.</p><p><strong>Strengths and limitations: </strong>This study contributes to limited research on CSB in non-Western cultures using a nationally probability-based sample in Japan. The measures lacked detail, so future studies should include more specific questions to evaluate treatment-seeking and other conditions. The small sa
背景:强迫性性行为障碍(CSBD)涉及持续的、重复的性行为,尽管努力阻止,但仍在继续,导致个人、家庭、社会、教育和职业功能的显著痛苦或损害。大多数强迫性性行为(CSB)的研究都集中在西方国家,而日本的强迫性性行为特征在很大程度上还没有被研究过。虽然在西方背景下对CSB寻求治疗的行为有记录,但有必要了解日本的这种行为,以改善精神卫生服务。目的:本横断面研究旨在阐明日本CSB、社会人口因素、最大性行为持续时间、生活满意度、负面后果、心理合共病和寻求治疗行为之间的关系。方法:采用基于网络的调查问卷,从日本全国18-59岁的成人概率样本中招募参与者,按出生性别、年龄组和居住区域按比例分配。共纳入1094名调查对象,其中男异性恋者占43.69%,M年龄= 39.9±11.6岁。结果:参与者完成强迫性性行为障碍量表-19(平均得分= 24.35±9.27),报告性行为频率、花在性行为上的时间、生活满意度、与性行为相关的负面后果、寻求治疗的行为以及共病情况,如抑郁(患者健康问卷-9)、焦虑(广泛性焦虑障碍-7)、成人注意缺陷多动障碍(ADHD)(成人注意缺陷多动障碍自述量表)。结果:根据CSBD-19分值,CSBD高危人群(n = 28; 2.56%)为异性恋男性的可能性大于女性(卡方检验)。与低风险个体相比,高风险个体在色情和手淫上花费的最长时间更长,对健康和亲密关系的生活满意度较低,在各个生活领域(如睡眠、社会活动、工作、家庭生活、财务和身体健康)经历了负面影响,并表现出抑郁、焦虑和多动症的症状。据报道,有三名CSBD高危患者寻求治疗。临床意义:在日本,CSBD高风险个体会经历负面后果和心理合并症,因此调查影响因素以提供有效的CSBD治疗至关重要。优势和局限性:本研究对非西方文化中基于国家概率的日本CSB研究做出了贡献。这些措施缺乏细节,因此未来的研究应该包括更具体的问题来评估寻求治疗和其他情况。小样本量限制了在比较高风险和低风险CSBD组时发现的普遍性。结论:本研究确定了日本CSBD高危人群的特征,强调了开发针对CSB的支持系统以确保有效治疗的必要性。
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引用次数: 0
Sexual activities, erectile dysfunction, and the use of sexual management strategies among assigned males with genital ablation interests. 对生殖器消融感兴趣的男性的性活动、勃起功能障碍和性管理策略的使用。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-28 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf085
Erik Wibowo, Thomas W Johnson, Richard J Wassersug, Jamie D Agapoff

Background: Assigned males with genital ablation interests may be at higher risk of having erectile dysfunction (ED), especially those who have gone through androgen suppressing pharmacological therapies, orchiectomy and/or penectomy.

Aim: To determine the prevalence and severity of ED in assigned males with castration interests, the types of management strategies they use and what factors are associated with using these strategies.

Methods: We launched an online survey on the Eunuch Archive website to better understand how common ED is, as well as sexual frequencies, and the use of sexual management strategies among assigned males with genital ablation interests.

Outcomes: ED and sexual activity frequencies, preferred role in sexual activities, and previous use of sexual management strategies.

Results: Data from 363 assigned male individuals (50.7 ± 15.6 years old; 23.6% and 3.7% had been orchiectomized and penectomized respectively) showed that 11.2% reported having ED 25-50% of the time, 12.8% had ED 50-75% of the time, and 22.9% had ED 75-100% of the time. Yet a large proportion remained sexually active. For example, 63.5%, 56.2% and 8.8% reported watching porn, masturbating, and having partnered sex several times a week respectively. During partnered sex, 13% of the participants preferred to be in the insertive role, whereas nearly 40% preferred to be in the receptive role. A quarter preferred non-penetrative sex. To maintain sexual activities, commonly used strategies included oral medication (38.8%), vacuum erection devices (25.6%), and strap-on dildo (17.5%). Penile sleeve, penile injection and penile support device were rarely used (<10%).

Clinical implications: Data from our study can be used by clinicians to advise their clients, for example individuals with genital ablation interest who seek to maintain their sexual activities.

Strengths & limitations: Participants completed validated questionnaires. Data were collected online and could not be independently verified.

Conclusions: A strong interest in genital ablation is often associated with a desire to be less sexual. Consistent with that is a high incidence of ED in this population. However, many men with exceptional interests in genital ablation nevertheless remain sexually active and use various strategies to maintain penetrative sex.

背景:对生殖器消融感兴趣的男性可能有更高的勃起功能障碍(ED)风险,特别是那些经历过雄激素抑制药物治疗、睾丸切除术和/或阴茎切除术的男性。目的:确定有阉割兴趣的指定男性ED的患病率和严重程度,他们使用的管理策略的类型以及与使用这些策略相关的因素。方法:我们在宦官档案网站上发起了一项在线调查,以更好地了解ED的常见程度、性频率以及对生殖器消融感兴趣的指定男性的性管理策略的使用情况。结果:ED和性活动频率,在性活动中的首选角色,以及以前使用的性管理策略。结果:363名男性(50.7±15.6岁,分别有23.6%和3.7%的男性切除了睾丸和阴茎)的数据显示,11.2%的人报告ED的发生率为25-50%,12.8%的人报告ED的发生率为50-75%,22.9%的人报告ED的发生率为75-100%。然而,很大一部分人仍然性生活活跃。例如,63.5%、56.2%和8.8%的人分别表示每周看色情片、手淫和有几次性行为。在有伴侣的性行为中,13%的参与者更喜欢插入角色,而近40%的参与者更喜欢接受角色。四分之一的人更喜欢非插入性行为。为了维持性活动,常用的策略包括口服药物(38.8%)、真空勃起装置(25.6%)和带式假阳具(17.5%)。很少使用阴茎套筒、阴茎注射和阴茎支撑装置(临床意义:临床医生可以使用我们研究的数据来建议他们的客户,例如对生殖器消融感兴趣的个体寻求维持其性活动。)优势与局限性:参与者完成有效问卷。数据是在线收集的,无法独立核实。结论:对生殖器消融术的强烈兴趣通常与性欲减少有关。与此相一致的是,这一人群中ED的发病率很高。然而,许多对生殖器消融有特殊兴趣的男性仍然保持性活跃,并使用各种策略来维持插入性行为。
{"title":"Sexual activities, erectile dysfunction, and the use of sexual management strategies among assigned males with genital ablation interests.","authors":"Erik Wibowo, Thomas W Johnson, Richard J Wassersug, Jamie D Agapoff","doi":"10.1093/sexmed/qfaf085","DOIUrl":"10.1093/sexmed/qfaf085","url":null,"abstract":"<p><strong>Background: </strong>Assigned males with genital ablation interests may be at higher risk of having erectile dysfunction (ED), especially those who have gone through androgen suppressing pharmacological therapies, orchiectomy and/or penectomy.</p><p><strong>Aim: </strong>To determine the prevalence and severity of ED in assigned males with castration interests, the types of management strategies they use and what factors are associated with using these strategies.</p><p><strong>Methods: </strong>We launched an online survey on the Eunuch Archive website to better understand how common ED is, as well as sexual frequencies, and the use of sexual management strategies among assigned males with genital ablation interests.</p><p><strong>Outcomes: </strong>ED and sexual activity frequencies, preferred role in sexual activities, and previous use of sexual management strategies.</p><p><strong>Results: </strong>Data from 363 assigned male individuals (50.7 ± 15.6 years old; 23.6% and 3.7% had been orchiectomized and penectomized respectively) showed that 11.2% reported having ED 25-50% of the time, 12.8% had ED 50-75% of the time, and 22.9% had ED 75-100% of the time. Yet a large proportion remained sexually active. For example, 63.5%, 56.2% and 8.8% reported watching porn, masturbating, and having partnered sex several times a week respectively. During partnered sex, 13% of the participants preferred to be in the insertive role, whereas nearly 40% preferred to be in the receptive role. A quarter preferred non-penetrative sex. To maintain sexual activities, commonly used strategies included oral medication (38.8%), vacuum erection devices (25.6%), and strap-on dildo (17.5%). Penile sleeve, penile injection and penile support device were rarely used (<10%).</p><p><strong>Clinical implications: </strong>Data from our study can be used by clinicians to advise their clients, for example individuals with genital ablation interest who seek to maintain their sexual activities.</p><p><strong>Strengths & limitations: </strong>Participants completed validated questionnaires. Data were collected online and could not be independently verified.</p><p><strong>Conclusions: </strong>A strong interest in genital ablation is often associated with a desire to be less sexual. Consistent with that is a high incidence of ED in this population. However, many men with exceptional interests in genital ablation nevertheless remain sexually active and use various strategies to maintain penetrative sex.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf085"},"PeriodicalIF":2.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560766/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401814","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Cognition of the association between sexual dysfunction and fertility. 性功能障碍与生育能力关系的认知。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-28 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf084
Yuying Sheng, Lewen Ruan, Yuge Chen, Xu Han, Baoyan Wu, Mingrong Lv, Dongdong Tang, Kuokuo Li

Background: While research has shown that sexual dysfunction does not impact fertility, public understanding of this relationship remains unclear.

Aim: To investigate the relationship between public cognition of the association between sexual dysfunction and fertility (ASDF) and the occurrence of sexual dysfunction itself.

Methods: This cross-sectional study utilized a nationally representative sample of 10 761 reproductive-age individuals across China. Participants completed an anonymous questionnaire assessing sexual function and ASDF cognition, using tools like IIEF-5, PEDT, and FSFI-19. Data analysis was conducted with R software, employing χ2 and Mann-Whitney U tests.

Outcomes: The study identified a significant correlation between ASDF cognition and the severity of sexual dysfunction, with lower levels of cognition associated with more severe dysfunction.

Results: Among 10 761 surveyed, 45.08% of men and 54.92% of women showed low ASDF cognition. There was a significant correlation between ASDF cognition and sexual dysfunction severity, with poor cognition associated with more severe ED and PE in men, and sexual intercourse pain in women.

Clinical implications: The findings suggest the need for targeted sexual health education to improve public understanding of sexual dysfunction and its impact on fertility.

Strengths and limitations: Strengths include a large nationally representative sample and the use of validated tools. Limitations are the China-focused sample and subjective assessment tools, which may limit broader applicability.

Conclusion: This study identifies a significant association between ASDF cognition and the severity of sexual dysfunction, underscoring the importance of public education on sexual health.

背景:虽然研究表明性功能障碍不会影响生育能力,但公众对这一关系的理解仍不清楚。目的:探讨公众对性功能障碍与生育(ASDF)关系的认知与性功能障碍本身的关系。方法:本横断面研究采用了全国代表性的10,761个育龄个体样本。参与者使用IIEF-5、PEDT和FSFI-19等工具完成了一份评估性功能和ASDF认知的匿名问卷。数据分析采用R软件,采用χ2和Mann-Whitney U检验。结果:该研究确定了ASDF认知与性功能障碍严重程度之间的显著相关性,认知水平越低,性功能障碍越严重。结果:受访的10761人中,45.08%的男性和54.92%的女性对ASDF认知较低。ASDF认知与性功能障碍严重程度之间存在显著相关性,认知不良与男性更严重的ED和PE相关,与女性性交疼痛相关。临床意义:研究结果表明,需要有针对性的性健康教育,以提高公众对性功能障碍及其对生育的影响的认识。优势和局限性:优势包括具有全国代表性的大样本和有效工具的使用。局限性在于以中国为重点的样本和主观评估工具,这可能会限制更广泛的适用性。结论:本研究确定了ASDF认知与性功能障碍严重程度之间的显著关联,强调了性健康公共教育的重要性。
{"title":"Cognition of the association between sexual dysfunction and fertility.","authors":"Yuying Sheng, Lewen Ruan, Yuge Chen, Xu Han, Baoyan Wu, Mingrong Lv, Dongdong Tang, Kuokuo Li","doi":"10.1093/sexmed/qfaf084","DOIUrl":"10.1093/sexmed/qfaf084","url":null,"abstract":"<p><strong>Background: </strong>While research has shown that sexual dysfunction does not impact fertility, public understanding of this relationship remains unclear.</p><p><strong>Aim: </strong>To investigate the relationship between public cognition of the association between sexual dysfunction and fertility (ASDF) and the occurrence of sexual dysfunction itself.</p><p><strong>Methods: </strong>This cross-sectional study utilized a nationally representative sample of 10 761 reproductive-age individuals across China. Participants completed an anonymous questionnaire assessing sexual function and ASDF cognition, using tools like IIEF-5, PEDT, and FSFI-19. Data analysis was conducted with R software, employing χ<sup>2</sup> and Mann-Whitney <i>U</i> tests.</p><p><strong>Outcomes: </strong>The study identified a significant correlation between ASDF cognition and the severity of sexual dysfunction, with lower levels of cognition associated with more severe dysfunction.</p><p><strong>Results: </strong>Among 10 761 surveyed, 45.08% of men and 54.92% of women showed low ASDF cognition. There was a significant correlation between ASDF cognition and sexual dysfunction severity, with poor cognition associated with more severe ED and PE in men, and sexual intercourse pain in women.</p><p><strong>Clinical implications: </strong>The findings suggest the need for targeted sexual health education to improve public understanding of sexual dysfunction and its impact on fertility.</p><p><strong>Strengths and limitations: </strong>Strengths include a large nationally representative sample and the use of validated tools. Limitations are the China-focused sample and subjective assessment tools, which may limit broader applicability.</p><p><strong>Conclusion: </strong>This study identifies a significant association between ASDF cognition and the severity of sexual dysfunction, underscoring the importance of public education on sexual health.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"13 5","pages":"qfaf084"},"PeriodicalIF":2.0,"publicationDate":"2025-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12560785/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145401748","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Preliminary psychometric linguistic validation of the satisfaction survey for inflatable penile implant in Spanish. 西班牙语充气式阴茎植入物满意度调查的初步心理测量语言学验证。
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-26 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf089
Jose M Flores, Bernardita M Ljubetic, Luis F Novaes, Edgardo F Becher, Ignacio Alvarez de Toledo, Alejandro Carvajal, Esteban Calle Correa, Esau Fernandez-Pascual, Juan Ignacio Martinez-Salamanca, Christian Nelson, Carolyn A Salter, Jose Torremade, Maurizio D'Anna, Robert Valenzuela, Alexander Negron, Sergio Moreno, Cristóbal Henríquez, Thomas M Atkinson, John P Mulhall

Background: Despite attempts to assess patient satisfaction with inflatable penile prosthesis (IPP) among Spanish-speaking populations, the absence of a validated, purpose-specific questionnaire in Spanish remains a significant gap.

Aim: This study aims to report the preliminary psychometric validation of Spanish Satisfaction Survey for Inflatable Penile Implant (SSIPI).

Methods: Six centers were selected to represent diverse Spanish-speaking populations in Latin America, the United States, and Spain. It included men who had IPP surgery between 6 months and 5 years ago. The translation and cultural adaptation of the SSIPI from English to Spanish followed a systematic multi-staged approach. Each participant received 4 surveys: (i) the final Spanish SSIPI, (ii) the IIEF erectile function domain (IIEF-EFD), (iii) the Self-Esteem and Relationship (SEAR) questionnaire, and (iv) the International Prostate Symptom Score (IPSS). Reliability, internal consistency, and intraclass correlation were evaluated. A convergent analysis was also used to evaluate Spanish SSIPI with SEAR and IIEF-EFD and a divergent analysis between Spanish SSIPI and IPSS.

Outcomes: Spanish SSIPI psychometric validation.

Results: A total of 111 participants were enrolled in the study. The median age was 64. The majority of participants (87%) were partnered, with a median relationship duration of 96 months. The median partner age was 56. Self-reported median time since IPP implantation was 21 months, with individuals indicating that they use the implant with a median of 5 times per month. Inflatable penile prosthesis satisfaction was generally high across all domains. Spanish SSIPI showed good reliability, high consistency, and high internal reliability across all SSIPI domains. Spanish SSIPI domains had significant correlations with the IIEF-EFD and SEAR. Spanish SSIPI domains were not significantly correlated with the overall IPSS score.

Clinical implications: Spanish SSIPI is a linguistically, culturally, and psychometrically validated patient-reported outcomes measure of satisfaction with IPP, facilitating cross-comparative analysis with previously validated English and French versions.

Strengths and limitations: This study demonstrates several methodological strengths, including applying a comprehensive psychometric approach, validating across multiple centers, and using a solid methodology to validate Spanish SSIPI. However, there are limitations, particularly the underrepresentation of specific subpopulations and the omission of pre-operative erectile function assessment.

Conclusion: The preliminary Spanish SSIPI demonstrated robust reliability and internal consistency across diverse Spanish-speaking regions.

背景:尽管试图评估西班牙语人群对充气阴茎假体(IPP)的患者满意度,但缺乏经过验证的西班牙语目的特定问卷仍然是一个重大差距。目的:本研究旨在报告西班牙语充气阴茎植入物满意度调查(SSIPI)的初步心理测量验证。方法:选择六个中心来代表拉丁美洲、美国和西班牙不同的西班牙语人群。研究对象包括6个月至5年前接受过IPP手术的男性。《SSIPI》的英西翻译和文化改编遵循了一个系统的多阶段方法。每位参与者接受4项调查:(i)西班牙语最终SSIPI, (ii) IIEF勃起功能域(IIEF- efd), (iii)自尊和关系(SEAR)问卷,以及(iv)国际前列腺症状评分(IPSS)。评估信度、内部一致性和类内相关性。用SEAR和IIEF-EFD对西班牙SSIPI进行了收敛分析,并对西班牙SSIPI和IPSS进行了发散分析。结果:西班牙SSIPI心理测量验证。结果:共有111名参与者被纳入研究。平均年龄为64岁。大多数参与者(87%)是伴侣,平均关系持续时间为96个月。伴侣年龄中位数为56岁。自IPP植入以来,自我报告的中位时间为21个月,个体表示他们每月使用植入物的中位次数为5次。充气阴茎假体在所有领域的满意度普遍较高。西班牙SSIPI在所有SSIPI域中表现出良好的可靠性、高一致性和高内部可靠性。西班牙语SSIPI域与IIEF-EFD和SEAR有显著相关性。西班牙SSIPI域与总体IPSS评分无显著相关。临床意义:西班牙语SSIPI是一种在语言、文化和心理计量学上经过验证的患者报告的IPP满意度结果测量,便于与先前经过验证的英语和法语版本进行交叉比较分析。优势和局限性:本研究展示了几种方法优势,包括应用综合心理测量方法,跨多个中心验证,以及使用可靠的方法验证西班牙SSIPI。然而,也存在局限性,特别是特定亚群的代表性不足和术前勃起功能评估的遗漏。结论:初步的西班牙语SSIPI在不同的西班牙语地区显示出强大的可靠性和内部一致性。
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引用次数: 0
The basis for self-reported sexual dysfunction and the diagnostic value of masturbation-related parameters in men who have not engaged in vaginal intercourse in the past 6 months or have never engaged in it: a comparative study. 自我报告性功能障碍的基础及自慰相关参数在过去6个月未进行阴道性交或从未进行过阴道性交的男性中的诊断价值:一项比较研究
IF 2 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-10-26 eCollection Date: 2025-10-01 DOI: 10.1093/sexmed/qfaf087
Zhihui Mao, Juanhui Ye, Karl H Pang, Chunlin Wang, Yan Zhang

Background: Men who have not engaged in vaginal intercourse in the past 6 months or have never engaged in it often seek help for sexual dysfunction, identifying factors influencing patients' self-assessment of sexual function and the value of masturbation-related parameters in diagnosing sexual dysfunction is of great importance.

Aim: This study aims to understand the reason why patients self-report sexual dysfunction and evaluate the role of masturbation parameters in diagnosing sexual dysfunction in self-reported sexual dysfunction (SRSD) and self-reported no sexual dysfunction (SRNSD) groups.

Methods: Our study was conducted mainly by filling out a questionnaire, which collected demographic information, sexual history as well as sexual parameters. The questionnaire summarized the basis of patients' self-reported sexual dysfunction and also included the Erection Hardness Score (EHS), Masturbation Erection Index (MEI), Masturbatory Premature Ejaculation Diagnostic Tool (MPEDT), and masturbatory ejaculation latency time (MELT).

Outcomes: The main outcomes were reasons for SRSD individuals to judge their sexual dysfunction, the EHS, MEI, MPEDT, and MELT scores.

Results: The most common complaints included insufficient erection hardness and short ejaculation latency time during masturbation, with 84.85% of self-reported erectile dysfunction and 91.80% of self-reported premature ejaculation patients reporting these issues. No significant difference was found between past vaginal sexual experiences (6 months ago) and current self-reported sexual dysfunction. Significant differences were found in EHS, MEI, MPEDT, and MELT scores between the SRSD and SRNSD groups. The MEI showed a sensitivity of 89.29% and a specificity of 81.82%. The MPEDT demonstrated a sensitivity of 98.04% and a specificity of 72.73%.

Clinical implications: We proposed that other than vaginal intercourse, sexual dysfunction should also be assessed from noncoital sex and verified the scientific validity of the masturbation parameters in people without recent vaginal intercourse.

Strengths & limitations: We firstly explored the patients self-perceived basis for sexual dysfunction. However, the objective instruments were not employed in diagnosing sexual dysfunction.

Conclusion: The findings emphasize the importance of a comprehensive clinical assessment that includes evaluating masturbation, noncoital sex (between men and women), morning erections, and past vaginal sexual experiences (6 months ago), moreover, masturbatory scales provide valuable insights in diagnosing sexual dysfunction.

背景:6个月未进行阴道性交或从未进行过阴道性交的男性常因性功能障碍寻求帮助,识别影响患者性功能自我评价的因素及自慰相关参数在诊断性功能障碍中的价值具有重要意义。目的:了解自述性功能障碍(SRSD)组和无性功能障碍(SRNSD)组患者自述性功能障碍的原因,评价自慰参数在诊断性功能障碍中的作用。方法:采用问卷调查的方式,收集人口统计信息、性史和性参数。问卷内容包括勃起硬度评分(EHS)、手淫勃起指数(MEI)、手淫早泄诊断工具(MPEDT)、手淫早泄潜伏期(MELT)等。结果:主要结果是SRSD个体判断其性功能障碍的原因、EHS、MEI、MPEDT和MELT评分。结果:自慰时勃起硬度不足和射精潜伏期短是最常见的症状,84.85%的自述勃起功能障碍患者和91.80%的自述早泄患者报告这些问题。过去的阴道性交经历(6个月前)和目前自我报告的性功能障碍之间没有显着差异。SRSD组与SRNSD组EHS、MEI、MPEDT、MELT评分差异有统计学意义。MEI的敏感性为89.29%,特异性为81.82%。MPEDT的敏感性为98.04%,特异性为72.73%。临床意义:我们建议,除了阴道性交,性功能障碍也应该从非性行为中评估,并验证最近没有阴道性交的人的手淫参数的科学有效性。优势与局限:首先探讨患者对性功能障碍的自我认知基础。然而,客观仪器在诊断性功能障碍方面的应用并不广泛。结论:研究结果强调了全面临床评估的重要性,包括评估手淫、非性交(男性和女性之间)、晨起和过去的阴道性经历(6个月前),此外,手淫量表为诊断性功能障碍提供了有价值的见解。
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Sexual Medicine
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