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The associations among platelet count, mean platelet volume, and erectile dysfunction: an observational and Mendelian randomization study. 血小板计数、平均血小板体积和勃起功能障碍之间的关系:一项观察性孟德尔随机研究。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-10 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae093
Jingxuan Peng, Jinshun An, Yuxing Chen, Jun Zhou, Boyu Xiang
<p><strong>Background: </strong>While previous studies have explored the associations and causalities among platelet count (PC), mean platelet volume (MPV), and erectile dysfunction (ED), further investigations are needed to clarify these relationships using advanced methodologies and analyzing specific populations.</p><p><strong>Aim: </strong>To investigate the associations and causalities among PC, MPV, and ED using observational study and Mendelian randomization (MR) analysis.</p><p><strong>Methods: </strong>A total of 114 patients with ED and 158 healthy control participants underwent a fasting blood draw to test for PC and MPV along with a comprehensive laboratory examination. The International Erectile Function Index was used to diagnose ED. Genetic variants of ED were obtained from individuals of European ancestry including 6175 ED cases and 217 630 controls. PC and MPV values were obtained from the UK Biobank and Investigating the effect of varying the whole blood inter-donation interval (INTERVAL) studies, encompassing a cohort of 173 480 individuals of European descent. Inverse-variant weighted (IVW), weighted median (WM), and MR-Egger methods were employed in MR analysis to explore the causal effects between variables to assess the impact of PC and MPV on ED. Various sensitivity analyses were employed to ensure the reliability of the results.</p><p><strong>Outcomes: </strong>Both observational study results and MR results revealed that elevated PC levels were associated with a heightened risk of ED, whereas reductions in MPV were linked to a decreased risk.</p><p><strong>Results: </strong>Logistic regression analysis indicated that an increased PC was associated with a greater risk of ED, with an odds ratio (OR) of 1.14 (95% CI: 1.08, 1.22; <i>P =</i> .005), whereas decreased MPV was linked to an increased risk for ED, with an OR of 0.65 (95% CI: 0.48, 0.88; <i>P =</i> .003). Our MR analysis also revealed that genetically predicted PC was associated with a 1.09-fold increased risk of ED (95% CI: 1.01, 1.18; <i>P</i> = .016). Conversely, genetically predicted MPV was linked to a 0.93-fold increased risk of ED (95% CI: 0.88, 0.99; <i>P</i> = .014). The absence of heterogeneity (<i>P</i> > .05) and pleiotropy (<i>P</i> > .05) was confirmed through Cochran's <i>Q</i> tests and MR-Egger regression. Exclusion of individual single-nucleotide polymorphisms (SNPs) did not alter the robustness of the results.</p><p><strong>Clinical implications: </strong>In clinical work, it is an important guide for the prevention, diagnosis, and treatment of ED.</p><p><strong>Strengths and limitations: </strong>Our study employed a combination of observational studies and MR studies to strengthen our evidence. The observational study's sample size was relatively small, and MR was limited to individuals of European ancestry.</p><p><strong>Conclusion: </strong>A high PC and a low MPV are associated with an increased risk of ED, highlighting the importance of add
背景:虽然之前的研究已经探讨了血小板计数(PC)、平均血小板体积(MPV)和勃起功能障碍(ED)之间的关联和因果关系,但需要进一步的研究来利用先进的方法和分析特定人群来澄清这些关系。目的:通过观察性研究和孟德尔随机化(MR)分析,探讨前列腺癌、MPV和ED之间的关系和因果关系。方法:114例ED患者和158名健康对照者进行空腹抽血检测PC和MPV,并进行综合实验室检查。使用国际勃起功能指数诊断ED。从欧洲血统的个体中获得ED的遗传变异,包括6175例ED病例和217 630例对照。PC和MPV值来自英国生物银行和调查全血献血间隔(interval)变化的影响的研究,包括173480名欧洲血统的个体。磁共振分析采用反变加权(IVW)、加权中位数(WM)和MR- egger方法来探讨变量之间的因果关系,以评估PC和MPV对ED的影响。采用各种敏感性分析来确保结果的可靠性。结果:观察性研究结果和MR结果都显示,PC水平升高与ED风险增加有关,而MPV降低与ED风险降低有关。结果:Logistic回归分析显示,PC升高与ED风险增加相关,比值比(OR)为1.14 (95% CI: 1.08, 1.22;P = 0.005),而MPV降低与ED风险增加相关,OR为0.65 (95% CI: 0.48, 0.88;P = .003)。我们的MR分析还显示,基因预测的PC与ED风险增加1.09倍相关(95% CI: 1.01, 1.18;p = .016)。相反,基因预测的MPV与ED风险增加0.93倍相关(95% CI: 0.88, 0.99;p = .014)。通过Cochran's Q检验和MR-Egger回归,证实不存在异质性(P > .05)和多效性(P > .05)。排除单个单核苷酸多态性(snp)并没有改变结果的稳健性。临床意义:在临床工作中,它是ed预防、诊断和治疗的重要指南。优势和局限性:我们的研究采用观察性研究和MR研究相结合的方法来加强我们的证据。观察性研究的样本量相对较小,MR仅限于欧洲血统的个体。结论:高PC和低MPV与ED风险增加相关,强调了处理血小板参数在ED管理中的重要性。
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引用次数: 0
Association of total testosterone levels with cardiometabolic diseases in men with erectile dysfunction. 总睾酮水平与勃起功能障碍男性心脏代谢疾病的关系
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-10 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae089
Bing-Tau Chen, Ping-Ju Tsai, Bang-Ping Jiann

Background: Both serum testosterone (T) levels and erectile dysfunction (ED) are associated with systemic diseases in men and ED is the most common presenting symptom of hypogonadism.

Aim: To evaluate the association of serum total testosterone (TT) levels with cardiometabolic diseases in men with ED.

Methods: Serum endogenous TT levels were determined to evaluate their associations with cardiometabolic diseases in men with ED in outpatient clinics. Participants were divided into hypogonadal with TT < 350 ng/dL (12.1 nmol/L) and eugonadal groups, as well as into four equal quartiles based on TT levels. The Framingham risk score was used to estimate individual 10-year coronary heart disease (CHD) risk.

Main outcome measures: Cardiometabolic factors included obesity, diabetes mellitus (DM), hypertension (HT), dyslipidemia, and the Framingham risk score.

Results: From 2010 to 2021, a total of 4467 subjects with ED were consecutively recruited for this study, and 3909 subjects' (87.5%) data with a mean age of 53.0 ± 12.9 (20.0-88.0) years had data eligible for analysis. Testosterone levels declined with age and a higher body mass index (BMI) was associated with lower T levels across all age groups (P < .001). Compared to the eugonadal group, the hypogonadal group was older and had a higher BMI and more cardiometabolic diseases (all P < .01). In multivariate analysis, odds ratio (OR) for hypogonadism was highest in men with obesity (2.51), followed by age group of ≥70 years (2.32), DM (1.59), HT (1.41), and dyslipidemia (1.26). Compared with the lowest TT quartile, higher quartiles of TT had significantly lower risk for cardiometabolic diseases (all P < .001). Among men over 50 yrs, hypogonadal men had a higher 10-year CHD risk than eugonadal men as predicted by the Framingham risk score (P < .001).

Clinical implications: Our results highlight the value of determining TT levels in men with ED because of their association with cardiometabolic diseases and the potential benefits of T therapy for improving men's health.

Strengths and limitations: Strengths of this study include a relatively large sample and detailed medical history collection. Limitations included a small portion of subjects with repeat TT tests, and the lack of data on free T and bioavailable T levels, and single-site recruitment.

Conclusions: TT levels are independently associated with cardiometabolic diseases including obesity, DM, HT, and dyslipidemia, and indicate a higher risk for CHD in men with ED. Measuring TT levels in men with ED presents an opportunity to improve overall health and reduce CV risk.

背景:血清睾酮(T)水平和勃起功能障碍(ED)与男性全身性疾病有关,ED是性腺功能减退症最常见的症状。目的:评价ED患者血清总睾酮(TT)水平与心脏代谢疾病的关系。方法:测定门诊ED患者血清内源性TT水平,评价其与心脏代谢疾病的关系。主要结局指标:心脏代谢因素包括肥胖、糖尿病(DM)、高血压(HT)、血脂异常和Framingham风险评分。结果:2010 - 2021年,本研究共招募ED患者4467例,其中3909例(87.5%)数据符合分析条件,平均年龄为53.0±12.9(20.0-88.0)岁。在所有年龄组中,睾酮水平随着年龄的增长而下降,较高的体重指数(BMI)与较低的睾酮水平相关(P P P P)。临床意义:我们的研究结果强调了在ED男性中测定睾酮水平的价值,因为睾酮水平与心脏代谢疾病有关,而且睾酮治疗对改善男性健康有潜在的益处。优势和局限性:本研究的优势在于样本相对较大,病史收集较为详细。局限性包括重复TT测试的受试者比例很小,缺乏游离T和生物可利用T水平的数据,以及单位点招募。结论:TT水平与心脏代谢疾病(包括肥胖、糖尿病、高血压和血脂异常)独立相关,并表明ED患者冠心病风险较高。测量ED患者TT水平为改善整体健康状况和降低心血管风险提供了机会。
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引用次数: 0
The association between comprehensive dietary antioxidant index and erectile dysfunction in adult men: a cross-sectional study from the 2001-2004 U.S. National Health and Nutrition Examination Survey. 综合膳食抗氧化指数与成年男性勃起功能障碍之间的关系:2001-2004年美国国家健康与营养调查的横断面研究。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-09 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae092
Meijun Liu, Peihai Zhang

Background: Increasing evidence suggests that a diet rich in antioxidants may prevent erectile dysfunction (ED), but the impact of comprehensive dietary antioxidants on ED has been little studied.

Aim: To investigate the association between the composite dietary antioxidant index (CDAI) and ED risk in adult men.

Methods: The study performed a cross-sectional analysis using data from the 2001-2004 National Health and Nutrition Examination Survey to investigate the association between the composite dietary antioxidant index (CDAI) and ED. The connection between the CDAI and ED was assessed using univariate and multivariate weighted logistic regression models, as well as the restricted cubic spline.

Outcomes: Association between the CDAI and the prevalence of ED.

Results: The study included a total of 3699 participants, among whom 1042 were diagnosed with ED, resulting in a prevalence of 28.17%. Multivariate weighted logistic regression consistently showed a negative association between the CDAI and ED (OR = 0.95, 95% CI: 0.92-0.98, P = .005). The group with the highest CDAI (Q4) had a 33% reduced risk of ED than the group with the lowest CDAI (Q1) when the CDAI was regarded as a categorical variable (OR = 0.67, 95% CI: 0.49-0.91, P = .014). Restricted cubic spline analysis showed that the CDAI was linearly related to the risk of ED (non-linearity P = .652). Furthermore, subgroup analysis indicated that the inverse relationship between CDAI and ED was more pronounced in individuals under 60 years of age, those with diabetes, and those without hypertension.

Clinical implications: Dietary strategies to increase antioxidant intake might offer a potential approach to reducing ED risk and supporting men's sexual health.

Strengths and limitations: This is a large-scale study investigating the association between the CDAI and ED. However, as a cross-sectional study, the timeliness of the dataset and the recall bias inherent in dietary data somewhat limit the reliability of the results.

Conclusion: This study identified a significant inverse association between the CDAI and ED risk among adult men in the United States; however, as a cross-sectional study, this research cannot establish causation, and further longitudinal studies are needed to validate these findings and provide more definitive evidence.

背景:越来越多的证据表明,富含抗氧化剂的饮食可以预防勃起功能障碍(ED),但综合膳食抗氧化剂对ED的影响研究甚少。目的:探讨膳食复合抗氧化指数(CDAI)与成年男性ED风险的关系。方法:利用2001-2004年全国健康与营养调查数据进行横断面分析,探讨膳食复合抗氧化指数(CDAI)与ED之间的关系。采用单因素和多因素加权logistic回归模型以及受限三次样条分析CDAI与ED之间的关系。结果:CDAI与ED患病率之间的关系。结果:该研究共纳入3699名参与者,其中1042人被诊断为ED,患病率为28.17%。多因素加权logistic回归一致显示CDAI与ED呈负相关(OR = 0.95, 95% CI: 0.92-0.98, P = 0.005)。当将CDAI作为一个分类变量时,CDAI最高(Q4)组的ED风险比CDAI最低(Q1)组降低33% (OR = 0.67, 95% CI: 0.49-0.91, P = 0.014)。限制三次样条分析显示,CDAI与ED风险呈线性相关(非线性P = .652)。此外,亚组分析表明,CDAI与ED之间的负相关关系在60岁以下、糖尿病患者和无高血压患者中更为明显。临床意义:增加抗氧化剂摄入的饮食策略可能提供降低ED风险和支持男性性健康的潜在途径。优势和局限性:这是一项调查CDAI和ED之间关系的大规模研究。然而,作为一项横断面研究,数据集的及时性和饮食数据固有的回忆偏倚在一定程度上限制了结果的可靠性。结论:本研究确定了美国成年男性CDAI与ED风险之间存在显著的负相关;然而,作为一项横断面研究,本研究无法建立因果关系,需要进一步的纵向研究来验证这些发现并提供更明确的证据。
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引用次数: 0
Exploring novel drug targets for erectile dysfunction through plasma proteome with genome. 利用血浆蛋白质组学与基因组技术探索治疗勃起功能障碍的新药物靶点。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-09 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae091
Zeming Qiu, Long Cheng, Qinyuan Wang, Zhilong Dong

Background: Currently, the treatment and prevention of erectile dysfunction (ED) remain highly challenging.

Aim: This study conducted a systematic druggable genome-wide Mendelian randomization (MR) analysis to identify potential therapeutic targets for ED.

Methods: A proteome-wide MR approach was employed to investigate the causal effects of plasma proteins on ED. Subsequently, summary data-based MR (SMR) analysis was performed to identify potential drug targets for ED. Enrichment analysis and protein-protein interaction (PPI) networks revealed the functional characteristics and biological relevance of these potential therapeutic targets. Drug prediction and molecular docking studies were conducted to validate the pharmacological activity of these identified targets. Finally, a systematic MR analysis was conducted to assess upstream intervention factors, such as lifestyles and diseases, associated with these targets, providing insights for the prevention and treatment of ED.

Outcomes: This study identified several potential therapeutic targets for ED.

Results: Proteome-wide MR analysis revealed that 126 genetically predicted plasma proteins were causally associated with ED. SMR analysis indicated that TMEM9 was associated with an increased risk of ED, while MDH1, NQO1, QDPR, ARL4D, TAGLN2, and PPP1R14A were associated with a decreased risk of ED. These potential targets were primarily enriched in metabolic and redox-related biological processes. Molecular docking indicated that the predicted drugs had favorable binding affinities with the proteins, further confirming the pharmacological value of these targets. Finally, 6 plasma proteins (MDH1, NQO1, QDPR, ARL4D, TAGLN2, and TMEM9) could be modulated by lifestyle- and disease-related factors.

Clinical implications: This study provides new insights into the etiology and potential drug targets of ED and contributes to the development of more effective treatments for ED and reducing the cost of drug development.

Strengths and limitations: This is a systematic and extensive study exploring the causal relationship between plasma proteins and ED, which helps to provide a comprehensive perspective to understand the role of potential targets in ED. However, we did not conduct this study in different types of ED or different stages of ED progression.

Conclusion: In summary, this study identified 7 plasma proteins causally associated with ED and provided new insights into the etiology and potential drug targets for ED.

背景:目前,勃起功能障碍(ED)的治疗和预防仍然具有很高的挑战性。目的:本研究通过系统的可用药全基因组孟德尔随机化(MR)分析,确定ed的潜在治疗靶点。采用蛋白质组范围的MR方法来研究血浆蛋白对ED的因果关系。随后,采用基于数据的MR (SMR)分析来确定ED的潜在药物靶点。富集分析和蛋白-蛋白相互作用(PPI)网络揭示了这些潜在治疗靶点的功能特征和生物学相关性。通过药物预测和分子对接研究来验证这些鉴定出的靶点的药理活性。最后,进行了系统的MR分析,以评估与这些靶点相关的上游干预因素,如生活方式和疾病,为ed的预防和治疗提供见解。蛋白质组级MR分析显示126个遗传预测血浆蛋白与ED有因果关系。SMR分析显示TMEM9与ED风险增加相关,而MDH1、NQO1、QDPR、ARL4D、TAGLN2和PPP1R14A与ED风险降低相关。这些潜在靶点主要富集于代谢和氧化还原相关的生物过程中。分子对接表明,预测药物与蛋白质具有良好的结合亲和力,进一步证实了这些靶点的药理价值。最后,6种血浆蛋白(MDH1、NQO1、QDPR、ARL4D、TAGLN2和TMEM9)可被生活方式和疾病相关因素调节。临床意义:本研究为ED的病因和潜在药物靶点提供了新的见解,有助于开发更有效的ED治疗方法,降低药物开发成本。优势和局限性:这是一项系统而广泛的研究,探索血浆蛋白与ED之间的因果关系,有助于提供一个全面的视角来理解潜在靶点在ED中的作用。然而,我们没有在不同类型的ED或ED进展的不同阶段进行这项研究。结论:本研究确定了7种与ED有因果关系的血浆蛋白,为ED的病因和潜在药物靶点提供了新的见解。
{"title":"Exploring novel drug targets for erectile dysfunction through plasma proteome with genome.","authors":"Zeming Qiu, Long Cheng, Qinyuan Wang, Zhilong Dong","doi":"10.1093/sexmed/qfae091","DOIUrl":"10.1093/sexmed/qfae091","url":null,"abstract":"<p><strong>Background: </strong>Currently, the treatment and prevention of erectile dysfunction (ED) remain highly challenging.</p><p><strong>Aim: </strong>This study conducted a systematic druggable genome-wide Mendelian randomization (MR) analysis to identify potential therapeutic targets for ED.</p><p><strong>Methods: </strong>A proteome-wide MR approach was employed to investigate the causal effects of plasma proteins on ED. Subsequently, summary data-based MR (SMR) analysis was performed to identify potential drug targets for ED. Enrichment analysis and protein-protein interaction (PPI) networks revealed the functional characteristics and biological relevance of these potential therapeutic targets. Drug prediction and molecular docking studies were conducted to validate the pharmacological activity of these identified targets. Finally, a systematic MR analysis was conducted to assess upstream intervention factors, such as lifestyles and diseases, associated with these targets, providing insights for the prevention and treatment of ED.</p><p><strong>Outcomes: </strong>This study identified several potential therapeutic targets for ED.</p><p><strong>Results: </strong>Proteome-wide MR analysis revealed that 126 genetically predicted plasma proteins were causally associated with ED. SMR analysis indicated that TMEM9 was associated with an increased risk of ED, while MDH1, NQO1, QDPR, ARL4D, TAGLN2, and PPP1R14A were associated with a decreased risk of ED. These potential targets were primarily enriched in metabolic and redox-related biological processes. Molecular docking indicated that the predicted drugs had favorable binding affinities with the proteins, further confirming the pharmacological value of these targets. Finally, 6 plasma proteins (MDH1, NQO1, QDPR, ARL4D, TAGLN2, and TMEM9) could be modulated by lifestyle- and disease-related factors.</p><p><strong>Clinical implications: </strong>This study provides new insights into the etiology and potential drug targets of ED and contributes to the development of more effective treatments for ED and reducing the cost of drug development.</p><p><strong>Strengths and limitations: </strong>This is a systematic and extensive study exploring the causal relationship between plasma proteins and ED, which helps to provide a comprehensive perspective to understand the role of potential targets in ED. However, we did not conduct this study in different types of ED or different stages of ED progression.</p><p><strong>Conclusion: </strong>In summary, this study identified 7 plasma proteins causally associated with ED and provided new insights into the etiology and potential drug targets for ED.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 6","pages":"qfae091"},"PeriodicalIF":2.6,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11710913/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142954680","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Identification of fibrosis-related genes and biomarkers in diabetic erectile dysfunction. 糖尿病性勃起功能障碍中纤维相关基因和生物标志物的鉴定。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-09 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae090
Wenjia Deng, Lingang Cui, Teng Li, Qingjun Meng, Taotao Sun, Penghui Yuan

Background: Diabetic erectile dysfunction (DMED) has a high incidence and is poorly treated.

Aim: This study investigates fibrosis's genetic profiling and explores potential mechanisms for DMED.

Methods: The DMED model was constructed in rats using streptozotocin. Erectile function was quantified using cavernous nerve electrostimulation. Fibrosis was evaluated using Masson's staining. RNA-seq was employed to analyze differentially expressed genes and fibrosis-related genes (FRGs) were acquired. Function enrichment analyses were performed, and genetic interaction was analyzed. Hub FRGs were screened using machine learning algorithms and Cytoscape tools and validated in Gene Expression Omnibus databases. Moreover, biological roles and subpopulation distribution of hub FRGs were determined.

Outcomes: Fibrosis-related genetic functions may play a vital role in DMED.

Results: Based on comprehensive analysis, 45 differentially expressed FRGs were identified. These genes participate in regulating smooth muscle cell proliferation, vasoconstriction, and collagen-associated activities. Final analyses identified and validated a core gene signature comprising TIMP1, BMP7, and POSTN. They were closely associated with diabetic complications-related signaling pathways and extracellular matrix-receptor interaction.

Clinical translation: The identified fibrosis-related gene signature may serve as the novel biomarkers for treating DMED.

Strengths and limitations: The study is the first to investigate the genetic profiles behind fibrosis and DMED using comprehensive approaches. However, the validation is not adequate and more animal experiments are needed.

Conclusion: The gene profiling and biological functions of FRGs in DMED were identified. These results broaden the understanding of fibrosis in DMED.

背景:糖尿病性勃起功能障碍(DMED)发病率高,治疗效果差。目的:研究纤维化的遗传谱,探讨DMED的潜在机制。方法:采用链脲佐菌素建立大鼠DMED模型。用海绵体神经电刺激定量测定勃起功能。马松染色法评估纤维化程度。采用RNA-seq分析差异表达基因,获得纤维化相关基因(FRGs)。功能富集分析和遗传互作分析。使用机器学习算法和Cytoscape工具筛选Hub FRGs,并在Gene Expression Omnibus数据库中进行验证。此外,还确定了枢纽FRGs的生物学作用和亚种群分布。结果:纤维化相关的遗传功能可能在DMED中起重要作用。结果:综合分析,鉴定出45个差异表达的frg。这些基因参与调节平滑肌细胞增殖、血管收缩和胶原相关活动。最后的分析确定并验证了一个核心基因签名,包括TIMP1、BMP7和POSTN。它们与糖尿病并发症相关的信号通路和细胞外基质-受体相互作用密切相关。临床翻译:鉴定的纤维化相关基因标记可能作为治疗DMED的新的生物标志物。优势和局限性:该研究是第一个使用综合方法调查纤维化和DMED背后的遗传谱的研究。然而,验证还不够充分,需要更多的动物实验。结论:确定了DMED中FRGs的基因谱和生物学功能。这些结果拓宽了对DMED中纤维化的理解。
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引用次数: 0
Histone deacetylase 6 inhibition prevents hypercholesterolemia-induced erectile dysfunction independent of changes in markers of autophagy. 组蛋白去乙酰化酶6抑制可预防高胆固醇血症引起的勃起功能障碍,而不依赖于自噬标志物的变化。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2025-01-09 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae096
Colin M Ihrig, McLane M Montgomery, Yohei Nomura, Mitsunori Nakano, Deepesh Pandey, Justin D La Favor
<p><strong>Background: </strong>Erectile dysfunction is a condition with a rapidly increasing prevalence globally with a strong correlation to the increase in obesity and cardiovascular disease rates.</p><p><strong>Aim: </strong>The aim of the current study is to investigate the potential role of tubacin, a histone deacetylase 6 (HDAC6) inhibitor, in restoring erectile function in a hypercholesterolemia-induced endothelial dysfunction model.</p><p><strong>Methods: </strong>Thirty-nine male C57Bl/6 J mice were divided into 3 groups. Two groups were administered an adeno-associated virus encoding for the gain of function of proprotein convertase subtilisin/kexin type 9 (PCSK9) and placed on a high-fat diet (HFD) with 1.25% cholesterol added for 18 weeks in order to induce a prolonged state of hypercholesterolemia. One of the PCSK9 groups received daily intraperitoneal injections of the HDAC6 inhibitor tubacin, while the other 2 groups received daily vehicle injections. Erectile function was assessed through measurement of intracavernosal pressure and mean arterial pressure during cavernous nerve stimulation, as well as assessment of agonist-stimulated ex vivo relaxation of the corpus cavernosum (CC). Western blotting was performed from CC tissue samples.</p><p><strong>Outcomes: </strong>Erectile and endothelial functions were assessed, as well as protein markers of mitochondrial dynamics, mitophagy, and autophagy.</p><p><strong>Results: </strong>Erectile function was impaired in the HFD + PCSK9 group throughout the entire voltage range of stimulation. However, the HFD + PCSK9 mice that were treated with tubacin experienced significant restoration of erectile function at the medium and high voltages of nerve stimulation. Similarly, ex vivo CC relaxation responses to acetylcholine and the cystathionine γ-lyase (CSE) substrate L-cysteine were reduced in the vehicle-treated HFD + PCSK9 mice, both of which were restored in the HFD + PCSK9 mice treated with tubacin. Corpus-cavernosum protein expression of CSE was significantly elevated in the tubacin-treated HFD + PCSK9 mice relative to both other groups. There were no significant differences observed in any of the protein markers of mitochondrial dynamics, mitophagy, or autophagy investigated.</p><p><strong>Clinical translation: </strong>Histone deacetylase 6 inhibition may protect against erectile and endothelial dysfunction associated with hypercholesterolemia.</p><p><strong>Strengths and limitations: </strong>This was the first study to investigate HDAC6-specific inhibition for treatment of erectile dysfunction. A study limitation was the exclusive focus on the CC, rather than structure and function of the pre-penile arteries that may develop a substantial atherosclerotic plaque burden under hypercholesterolemic conditions.</p><p><strong>Conclusions: </strong>Tubacin may prevent hypercholesterolemia-induced erectile dysfunction through a hydrogen sulfide-related mechanism unrelated to regulation of m
背景:勃起功能障碍是一种全球患病率迅速增加的疾病,与肥胖和心血管疾病发病率的增加密切相关。目的:本研究的目的是研究tubacin(一种组蛋白去乙酰化酶6 (HDAC6)抑制剂)在高胆固醇血症诱导的内皮功能障碍模型中恢复勃起功能的潜在作用。方法:雄性C57Bl/ 6j小鼠39只分为3组。两组小鼠分别注射一种编码枯草素/ keexin 9型蛋白转化酶(PCSK9)功能的腺相关病毒,并饲喂添加1.25%胆固醇的高脂饮食(HFD) 18周,以诱导延长高胆固醇血症状态。其中一个PCSK9组每天腹腔注射HDAC6抑制剂tubacin,另外两个组每天接受载体注射。通过测量海绵体神经刺激时的海绵体内压和平均动脉压,以及评估激动剂刺激的海绵体体外松弛(CC)来评估勃起功能。对CC组织样本进行Western blotting。结果:评估勃起和内皮功能,以及线粒体动力学、线粒体自噬和自噬的蛋白质标志物。结果:HFD + PCSK9组在整个刺激电压范围内勃起功能受损。然而,用tubacin治疗的HFD + PCSK9小鼠在中高压神经刺激下勃起功能明显恢复。同样,HFD + PCSK9小鼠对乙酰胆碱和胱氨酸γ-裂解酶(CSE)底物l -半胱氨酸的体外CC松弛反应在载药处理的小鼠中降低,而在tubacin处理的HFD + PCSK9小鼠中这两种松弛反应都得到恢复。与其他两组相比,tubacin处理的HFD + PCSK9小鼠体表海绵体中CSE蛋白的表达显著升高。在线粒体动力学、线粒体自噬或自噬的任何蛋白质标记中均未观察到显著差异。临床翻译:组蛋白去乙酰化酶6抑制可预防与高胆固醇血症相关的勃起和内皮功能障碍。优势和局限性:这是第一个研究hdac6特异性抑制治疗勃起功能障碍的研究。研究的一个局限性是只关注CC,而不是在高胆固醇血症条件下可能产生大量动脉粥样硬化斑块负担的阴茎前动脉的结构和功能。结论:结核菌素可能通过与线粒体自噬或自噬调节无关的硫化氢相关机制预防高胆固醇血症引起的勃起功能障碍。
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引用次数: 0
Analysis of the International Index of Erectile Function: psychometric evidence and measurement invariance across relationship status and age generations in a Chilean sample. 国际勃起功能指数的分析:心理测量证据和测量不变性在关系状态和年龄代际智利样本。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-30 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae084
Gonzalo R Quintana, Fernando P Ponce, Javier Escudero-Pastén, J Francisco Santibáñez-Palma, Carolina P Aguayo-Zuñiga, Mercedes Carrasco-Portiño, Marcela Cid-Aguayo, Mauricio González-Arias, Paola Ilabaca, Rodrigo Jarpa-Schäcker, Claudio López-Labarca, Marco A Marrodán, Nadia Ramos, Leonardo Reyes-Torres, Valeria Rosales-Pincetti, María T Solis-Soto, Anna Wlodarczyk, Jaime Barrientos

Background: The International Index of Erectile Function (IIEF) stands out for its utility and widespread use to measure sexual function in men. However, it lacks consistency in its internal latent structure across studies, has not been evaluated for measurement invariance, and has not undergone psychometric validation for its 15-item form in Spanish among South American countries.

Aim: To examine the IIEF's psychometric evidence (ie, structural/criterion validity and reliability) in a sample of adult men and determine its measurement invariance across relationship status (single vs in a relationship) and age generations (generations Z, Y/millennials, and X).

Methods: A sample of 650 sexually active males was derived from a broader Chilean study (Chilean Sex and Sexuality Study). We used a confirmatory factor analysis to determine the IIEF's structural validity, sexual satisfaction dimensions to establish its criterion-related validity, and Cronbach alpha and McDonald omega to assess the reliability of its scores.

Outcomes: Measures of goodness of fit.

Results: The evidence supported the 5-factor latent solution. Meanwhile, criterion-related validity revealed subtle yet significant differences in sexual satisfaction, with younger men displaying higher satisfaction in various sexual domains. In contrast, middle-aged men and those in a relationship showed better sexual function. Finally, the IIEF was invariant across age groups and relationship status at the factor covariance level.

Clinical translation: This study provides evidence that the IIEF is a valid, reliable, and invariant tool for the clinical practice in men's sexual health, particularly that associated with their sexual function and dysfunction.

Strengths and limitations: The study included a comprehensive validity analysis of the IIEF's psychometric properties, demonstrating its reliability and validity across diverse Chilean male subpopulations. The study also offered the IIEF's first assessment of measurement invariance and confirmed its suitability for clinical and research use in the Chilean population. Meanwhile, the study's limitations include a lack of clinical population and a sample predominantly younger, cisgender, and heterosexual.

Conclusion: Our study provides evidence of the IIEF's 5-factor structure and measurement invariance across age generations and relationship status in Chilean men, supporting its validity for clinical use and research and broadening its applicability in global sexual health studies, particularly in the Spanish-speaking South American male population.

背景:国际勃起功能指数(IIEF)因其实用性和广泛用于测量男性性功能而脱颖而出。然而,在不同的研究中,它的内部潜在结构缺乏一致性,没有被评估测量的不变性,也没有在南美国家的西班牙语中对其15个项目的形式进行心理测量验证。目的:在成年男性样本中检验IIEF的心理测量证据(即结构/标准效度和信度),并确定其在关系状态(单身vs有关系)和年龄代际(Z代、Y代/千禧一代和X代)中的测量不变性。方法:来自智利一项更广泛的研究(智利性与性研究)的650名性活跃男性样本。我们使用验证性因子分析来确定IIEF的结构效度,性满意度维度来建立其标准相关效度,并使用Cronbach alpha和McDonald omega来评估其得分的信度。结果:测量拟合优度。结果:证据支持5因素潜在溶液。与此同时,标准效度在性满意度上存在细微但显著的差异,年轻男性在不同的性领域表现出更高的满意度。相比之下,中年男性和有伴侣的男性表现出更好的性功能。最后,在因子协方差水平上,IIEF在不同年龄组和关系状态下是不变的。临床翻译:本研究提供了证据,证明IIEF是男性性健康临床实践的有效、可靠和不变的工具,特别是与性功能和功能障碍相关的工具。优势和局限性:该研究包括对IIEF心理测量特性的全面效度分析,证明其在智利不同男性亚群中的可靠性和效度。该研究还提供了IIEF对测量不变性的首次评估,并确认了其在智利人群中临床和研究使用的适用性。同时,该研究的局限性包括缺乏临床人群和样本主要是年轻人,顺性和异性恋。结论:我们的研究为IIEF的五因素结构和测量在智利男性中跨年龄代和关系状态的不变性提供了证据,支持其临床使用和研究的有效性,并扩大了其在全球性健康研究中的适用性,特别是在讲西班牙语的南美男性人群中。
{"title":"Analysis of the International Index of Erectile Function: psychometric evidence and measurement invariance across relationship status and age generations in a Chilean sample.","authors":"Gonzalo R Quintana, Fernando P Ponce, Javier Escudero-Pastén, J Francisco Santibáñez-Palma, Carolina P Aguayo-Zuñiga, Mercedes Carrasco-Portiño, Marcela Cid-Aguayo, Mauricio González-Arias, Paola Ilabaca, Rodrigo Jarpa-Schäcker, Claudio López-Labarca, Marco A Marrodán, Nadia Ramos, Leonardo Reyes-Torres, Valeria Rosales-Pincetti, María T Solis-Soto, Anna Wlodarczyk, Jaime Barrientos","doi":"10.1093/sexmed/qfae084","DOIUrl":"10.1093/sexmed/qfae084","url":null,"abstract":"<p><strong>Background: </strong>The International Index of Erectile Function (IIEF) stands out for its utility and widespread use to measure sexual function in men. However, it lacks consistency in its internal latent structure across studies, has not been evaluated for measurement invariance, and has not undergone psychometric validation for its 15-item form in Spanish among South American countries.</p><p><strong>Aim: </strong>To examine the IIEF's psychometric evidence (ie, structural/criterion validity and reliability) in a sample of adult men and determine its measurement invariance across relationship status (single vs in a relationship) and age generations (generations Z, Y/millennials, and X).</p><p><strong>Methods: </strong>A sample of 650 sexually active males was derived from a broader Chilean study (Chilean Sex and Sexuality Study). We used a confirmatory factor analysis to determine the IIEF's structural validity, sexual satisfaction dimensions to establish its criterion-related validity, and Cronbach alpha and McDonald omega to assess the reliability of its scores.</p><p><strong>Outcomes: </strong>Measures of goodness of fit.</p><p><strong>Results: </strong>The evidence supported the 5-factor latent solution. Meanwhile, criterion-related validity revealed subtle yet significant differences in sexual satisfaction, with younger men displaying higher satisfaction in various sexual domains. In contrast, middle-aged men and those in a relationship showed better sexual function. Finally, the IIEF was invariant across age groups and relationship status at the factor covariance level.</p><p><strong>Clinical translation: </strong>This study provides evidence that the IIEF is a valid, reliable, and invariant tool for the clinical practice in men's sexual health, particularly that associated with their sexual function and dysfunction.</p><p><strong>Strengths and limitations: </strong>The study included a comprehensive validity analysis of the IIEF's psychometric properties, demonstrating its reliability and validity across diverse Chilean male subpopulations. The study also offered the IIEF's first assessment of measurement invariance and confirmed its suitability for clinical and research use in the Chilean population. Meanwhile, the study's limitations include a lack of clinical population and a sample predominantly younger, cisgender, and heterosexual.</p><p><strong>Conclusion: </strong>Our study provides evidence of the IIEF's 5-factor structure and measurement invariance across age generations and relationship status in Chilean men, supporting its validity for clinical use and research and broadening its applicability in global sexual health studies, particularly in the Spanish-speaking South American male population.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 6","pages":"qfae084"},"PeriodicalIF":2.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11683729/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142907453","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Comparison of melanocortin-4 reptor and α-melanoside stimulated hormone levels in healthy female volunteers and female patients with and without sexual functional disorders related to the use of selective serotonin reaptake inhibitors. 对比使用选择性血清素再摄取抑制剂对健康女性志愿者和有或无性功能障碍女性患者黑素皮质素-4报告受体和α-黑素苷刺激激素水平的影响
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-20 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae085
Simge N Kurt Kaya, Yasir Safak, Seyda Ozdemir

Background: Sexual dysfunction (SD) due to Selective Serotonin Reuptake Inhibitors (SSRI) use is a common condition encountered by psychiatrists and its etiology has not been fully elucidated.

Aim: To determine the relationship between alpha Melanocyte Stimulating Hormone (α-MSH) and Melanocortin-4 receptor (MCR4) levels and sexual function levels of patients with and without SSRI related SD and control group and to examine whether α-MSH and MCR4 play a role in the etiology of SSRI related SD.

Methods: A total of 92 patients and 49 healthy volunteers who applied to psychiatry outpatient clinic were included in the study. Sociodemographic form, sexual history form, Structured Clinical Interview for DSM 5, Psychotropic Related Sexual Dysfunction-Turkish version (PreSexDQ-T), Arizona Sexual Experiences Scale, Beck Depression and Anxiety Inventory were used in the evaluation interview with the referred patients. Patient groups were formed according to whether there was SSRI related SD according to the sexual history and PreSexDQ-T scale.

Outcomes: The α-MSH and MCR4 levels were significantly lower in patients with SD due to SSRI use.

Results: α-MSH and MCR4 levels were lower in the SSRI related SD (SSRI-SD (+)) group than in the not experiencing SD with SSRIs (SSRI-SD (-)) and control groups. The mean α-MSH and MCR4 value of the control group was found to be significantly higher than the SSRI-SD (+) patient group, the mean MCR4 value of the control group was found to be significantly higher than the mean MCR4 value of the SSRI-SD (-) patient group. The mean MCR4 and a-MSH values of the SSRI-SD(+) group using SSRI with fluoxetine were significantly lower than the SSRI-SD (-) group using SSRI with fluoxetine.

Clinical implications: There is a role for α-MSH and MCR4 in SSRI related SD.

Strengths and limitations: Its strength is that it is the first human study in this field. Limitations include small sample size and unknown baseline levels of α-MSH and MCR4.

Conclusion: The fact that α-MSH and MCR4 play a role in the etiology of SD due to SSRI use in woman and that there was a significant difference between SSRI-SD (+) and SSRI-SD (-) groups when α-MSH and MCR4 levels were compared in fluoxetine users supports the hypothesis that serotonin may mediate SD via α-MSH and MCR4 through 5-hydroxytryptamine-2C (5-HT2C) antagonism.

背景:选择性5 -羟色胺再摄取抑制剂(SSRI)引起的性功能障碍(SD)是精神科医生遇到的一种常见疾病,其病因尚未完全阐明。目的:探讨α-促黑素细胞激素(α-MSH)和黑色素皮质素-4受体(MCR4)水平与SSRI相关性SD患者及对照组性功能水平的关系,探讨α-MSH和MCR4是否在SSRI相关性SD的发病机制中起作用。方法:共纳入92例精神科门诊患者和49名健康志愿者。采用社会人口学量表、性史量表、DSM - 5结构化临床访谈、土耳其版PreSexDQ-T、亚利桑那性经验量表、贝克抑郁焦虑量表对转诊患者进行评估访谈。根据性史和PreSexDQ-T量表,根据是否存在SSRI相关的SD组成患者组。结果:SD患者服用SSRI后α-MSH和MCR4水平明显降低。结果:SSRI相关SD (SSRI-SD(+))组α-MSH和MCR4水平低于未SSRI-SD(-)组和对照组。对照组α-MSH均值和MCR4值显著高于SSRI-SD(+)组,对照组MCR4均值显著高于SSRI-SD(-)组。SSRI- sd(+)组与氟西汀联合使用SSRI的平均MCR4和a-MSH值显著低于SSRI- sd(-)组与氟西汀联合使用SSRI。临床意义:α-MSH和MCR4在SSRI相关性SD中发挥作用。优势和局限性:它的优势在于它是该领域的第一个人类研究。局限性包括样本量小,α-MSH和MCR4的基线水平未知。结论:α-MSH和MCR4在女性SSRI所致SD的病因学中起作用,并且在氟西汀使用者中比较α-MSH和MCR4水平时,SSRI-SD(+)组和SSRI-SD(-)组之间存在显著差异,这支持了血清素可能通过α-MSH和MCR4通过5-羟色胺- 2c (5-HT2C)拮抗作用介导SD的假设。
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引用次数: 0
Extracorporeal shock wave therapy as a treatment option for persistent clitoral priapism: a case report. 体外冲击波治疗作为持续性阴蒂勃起的一种治疗选择:1例报告。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-12-03 eCollection Date: 2024-12-01 DOI: 10.1093/sexmed/qfae082
Karis Buford, Lauren Phung, Bernadette M M Zwaans, Priya Padmanabhan, Rachel S Rubin, Kenneth M Peters

Introduction: Clitoral priapism is persistent clitoral engorgement without sexual stimulation. Presentation is sparse, and therefore limited treatment options have been investigated.

Aim: We present a case report of a 34-year-old female presenting with persistent nonischemic clitoral priapism 5 years after aggressive clitoral stimulation.

Methods: Patient underwent six weekly Li-ESWT sessions at frequency 4 Hz, energy 0.11 mJ for 2000 shocks per session. Assessment included physical examination of clitoral glans engorgement and retraction, global response assessment (GRA) score, need for topical phenylephrine, and ability to achieve orgasm.

Results: At the end of the therapy, examination revealed complete resolution of priapism with a normal-appearing clitoris fully retracted behind the clitoral hood. The patient reported no longer requiring topical phenylephrine, a significant improvement in GRA, and the ability to achieve orgasm.

Conclusion: We present a case of nonischemic clitoral priapism resolved with Li-ESWT. More investigation regarding the utilization of Li-ESWT in the treatment of clitoral priapism is highly encouraged.

简介:阴蒂勃起是指在没有性刺激的情况下阴蒂持续充血。表现稀少,因此研究了有限的治疗方案。目的:我们报告一例34岁女性在积极刺激阴蒂5年后出现持续性非缺血性阴蒂勃起。方法:患者每周接受6次频率为4hz的Li-ESWT治疗,每次治疗2000次,能量0.11 mJ。评估包括阴蒂龟头扩张和收缩的体格检查,总体反应评估(GRA)评分,局部使用苯肾上腺素的需求,以及达到性高潮的能力。结果:在治疗结束时,检查显示阴茎勃起完全消退,阴蒂完全缩回到阴蒂后。患者报告不再需要局部使用苯肾上腺素,GRA显著改善,并有能力达到性高潮。结论:我们报告了一例用Li-ESWT治疗的非缺血性阴蒂勃起。我们鼓励更多关于Li-ESWT在治疗阴蒂勃起中的应用的研究。
{"title":"Extracorporeal shock wave therapy as a treatment option for persistent clitoral priapism: a case report.","authors":"Karis Buford, Lauren Phung, Bernadette M M Zwaans, Priya Padmanabhan, Rachel S Rubin, Kenneth M Peters","doi":"10.1093/sexmed/qfae082","DOIUrl":"10.1093/sexmed/qfae082","url":null,"abstract":"<p><strong>Introduction: </strong>Clitoral priapism is persistent clitoral engorgement without sexual stimulation. Presentation is sparse, and therefore limited treatment options have been investigated.</p><p><strong>Aim: </strong>We present a case report of a 34-year-old female presenting with persistent nonischemic clitoral priapism 5 years after aggressive clitoral stimulation.</p><p><strong>Methods: </strong>Patient underwent six weekly Li-ESWT sessions at frequency 4 Hz, energy 0.11 mJ for 2000 shocks per session. Assessment included physical examination of clitoral glans engorgement and retraction, global response assessment (GRA) score, need for topical phenylephrine, and ability to achieve orgasm.</p><p><strong>Results: </strong>At the end of the therapy, examination revealed complete resolution of priapism with a normal-appearing clitoris fully retracted behind the clitoral hood. The patient reported no longer requiring topical phenylephrine, a significant improvement in GRA, and the ability to achieve orgasm.</p><p><strong>Conclusion: </strong>We present a case of nonischemic clitoral priapism resolved with Li-ESWT. More investigation regarding the utilization of Li-ESWT in the treatment of clitoral priapism is highly encouraged.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 6","pages":"qfae082"},"PeriodicalIF":2.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11630007/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142814237","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Global web trends analysis of sex toys. 性玩具全球网络趋势分析。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-11-26 eCollection Date: 2024-10-01 DOI: 10.1093/sexmed/qfae072
Müslim Doğan Değer, Burak Akgul

Background: Individuals from all over the world are increasingly using the internet to purchase sex toys and gadgets to enhance their sexual experience and provide variety and excitement to their sexual encounters.

Aim: This study examined the trends about the most popular preferred sex toys by nation/region from 2009 using data from Google Trends (GT).

Methods: GT was used to generate a "line-graph" that displays how interest in a topic in certain places has risen or diminished over time. Search terms were generated for vibrator, dildo, anal plug, strap-on, and masturbator. The data were included "globally" from January 1, 2009 to June 30, 2023.

Outcomes: The search values for certain terms were indexed using the relative search volume (RSV), which is shown on a scale of 0-100.

Results: In the linear regression analysis, the trends by strength were sorted as follows: dildo, vibrator, strap-on, anal plug, and masturbator. In 2018, vibrator surpassed strap-on and came in second, while the regression analysis showed a positive trend for dildo between 2009 and 2016 (P = .014). It had a negative trend after 2016. Strap-on was the only one to have a downward trend (P = .029). Regression analysis revealed positive trends for vibrator and masturbator (P = .030, P = .045). The upward trends have continued uninterruptedly since 2009.

Clinical implications: According to our research, interest in online trends relating to sex toys has increased along with advancements in technology and clinical applications. This rise is linked to the worldwide sex toy industry's development in response to consumer demand and ease of accessibility.

Strengths and limitations: This is the first research of this sort, looking into the interests of internet users about sex toys by country over time using GT. GT data is anonymous, and analysis of subpopulation groups is not possible.

Conclusion: Individual preferences for sex toys have different trends on different continents around the world. The compatibility of sex toys with technology over time, their clinical use, and sex toy-related injuries play an important role in the selection process. Web trends seem appropriate to reflect how the demand for sex toys has changed over time.

背景:目的:本研究利用谷歌趋势(Google Trends,GT)的数据,研究了 2009 年各国/各地区最受欢迎的性玩具的发展趋势:方法:利用谷歌趋势生成 "线形图",显示某些地方对某一话题的兴趣随着时间的推移是如何上升或下降的。搜索词包括振动器、假阳具、肛门塞、捆绑带和自慰器。数据包括 2009 年 1 月 1 日至 2023 年 6 月 30 日的 "全球 "结果:使用相对搜索量(RSV)对某些术语的搜索值进行索引,RSV 以 0-100 表示:在线性回归分析中,按强度排序的趋势如下:假阳具、振动器、背带式、肛塞和自慰器。2018 年,振动器超过了背带式,位居第二,而回归分析显示,假阳具在 2009 年至 2016 年间呈正趋势(P = .014)。2016 年之后,它出现了负趋势。只有捆绑带呈下降趋势(P = 0.029)。回归分析表明,振动器和自慰器呈正趋势(P = .030,P = .045)。自 2009 年以来,上升趋势一直没有间断过:根据我们的研究,随着技术和临床应用的进步,人们对性玩具相关在线趋势的兴趣也在增加。这种增长与全球性玩具行业为满足消费者需求和方便使用而发展有关:这是首次开展此类研究,利用 GT 调查不同国家网民对性玩具的兴趣。GT 数据是匿名的,因此无法对子人群进行分析:结论:在世界各大洲,个人对性玩具的偏好有着不同的趋势。性玩具随着时间的推移与技术的兼容性、临床使用以及与性玩具相关的伤害在选择过程中起着重要作用。网络趋势似乎适合反映性玩具需求随着时间的推移而发生的变化。
{"title":"Global web trends analysis of sex toys.","authors":"Müslim Doğan Değer, Burak Akgul","doi":"10.1093/sexmed/qfae072","DOIUrl":"10.1093/sexmed/qfae072","url":null,"abstract":"<p><strong>Background: </strong>Individuals from all over the world are increasingly using the internet to purchase sex toys and gadgets to enhance their sexual experience and provide variety and excitement to their sexual encounters.</p><p><strong>Aim: </strong>This study examined the trends about the most popular preferred sex toys by nation/region from 2009 using data from Google Trends (GT).</p><p><strong>Methods: </strong>GT was used to generate a \"line-graph\" that displays how interest in a topic in certain places has risen or diminished over time. Search terms were generated for vibrator, dildo, anal plug, strap-on, and masturbator. The data were included \"globally\" from January 1, 2009 to June 30, 2023.</p><p><strong>Outcomes: </strong>The search values for certain terms were indexed using the relative search volume (RSV), which is shown on a scale of 0-100.</p><p><strong>Results: </strong>In the linear regression analysis, the trends by strength were sorted as follows: dildo, vibrator, strap-on, anal plug, and masturbator. In 2018, vibrator surpassed strap-on and came in second, while the regression analysis showed a positive trend for dildo between 2009 and 2016 (<i>P</i> = .014). It had a negative trend after 2016. Strap-on was the only one to have a downward trend (<i>P</i> = .029). Regression analysis revealed positive trends for vibrator and masturbator (<i>P</i> = .030, <i>P</i> = .045). The upward trends have continued uninterruptedly since 2009.</p><p><strong>Clinical implications: </strong>According to our research, interest in online trends relating to sex toys has increased along with advancements in technology and clinical applications. This rise is linked to the worldwide sex toy industry's development in response to consumer demand and ease of accessibility.</p><p><strong>Strengths and limitations: </strong>This is the first research of this sort, looking into the interests of internet users about sex toys by country over time using GT. GT data is anonymous, and analysis of subpopulation groups is not possible.</p><p><strong>Conclusion: </strong>Individual preferences for sex toys have different trends on different continents around the world. The compatibility of sex toys with technology over time, their clinical use, and sex toy-related injuries play an important role in the selection process. Web trends seem appropriate to reflect how the demand for sex toys has changed over time.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 5","pages":"qfae072"},"PeriodicalIF":2.6,"publicationDate":"2024-11-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11596685/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142732491","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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Sexual Medicine
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