首页 > 最新文献

Sexual Medicine最新文献

英文 中文
Retrospective analysis of the efficacy of low-intensity extracorporeal shock wave therapy on young and middle-aged patients with erectile dysfunction responsive to PDE5Is: reducing the use of PDE5Is. 低强度体外冲击波疗法对使用 PDE5Is 的中青年勃起功能障碍患者疗效的回顾性分析:减少 PDE5Is 的使用。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-29 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae065
Rui-Jie Yao, Mao-Yuan Wang, Qiang Chen, Hong Xiao, Peng Yang, Yi-Lang Ding, Xi Chen, Song-Xi Tang, Hui-Liang Zhou

Background: Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a new method for treating erectile dysfunction (ED), but there are no standards yet for its indications.

Aim: The study aimed to suggest the early clinical efficacy of Li-ESWT and explore its related factors in young and middle-aged patients with ED who responded to phosphodiesterase type 5 Inhibitors (PDE5Is).

Methods: Data from 61 patients with ED who had previously responded to oral PDE5Is and subsequently underwent Li-ESWT were collected. This included information on age, body mass index, total testicular volume, sex hormones, as well as IIEF-EF scores before treatment and at 1, 3, and 6 months after treatment. The treatment regimen involves a weekly session for four consecutive weeks, with each session administering 5000 shock wave pulses. Linear regression analysis was utilized to identify factors associated with the efficacy of Li-ESWT treatment. Additionally, the improvement in different severity groups of ED before and after treatment, along with their IIEF-EF scores, was compared.

Outcomes: Li-ESWT was more targeted and effective for young and middle-aged patients with erectile dysfunction who responded to PDE5Is.

Results: The age of enrolled patients ranges from 22 to 53 years old, and the IIEF-EF scores at 1 month, 3 months, and 6 months after treatment were compared to baseline for efficacy assessment, showing significant improvements (P < .0001) in all instances. Linear regression analysis using baseline data revealed predictive factors associated with treatment efficacy: treatment efficacy was negatively correlated with baseline IIEF-EF scores (t = -2.599, P = .013) and positively correlated with baseline LH levels (t = 2.170, P = .036).

Clinical implications: Given the considerable cost of Li-ESWT treatment and the emphasis on treatment continuity, we hope to identify the most suitable candidates for Li-ESWT therapy, thereby optimizing its application.

Strengths and limitations: Our findings provide a better solution for nonelderly ED patients who are responsive to PDE5Is. This study was limited by our sample size and follow-up time.

Conclusion: After 3 months of Li-ESWT, the IIEF-EF score gradually stabilizes and short-term maintenance of PDE5Is medication increases the responsiveness to shock wave therapy.

背景:低强度体外冲击波疗法(Li-ESWT)是治疗勃起功能障碍(ED)的一种新方法,但其适应症尚无标准。研究目的:本研究旨在提示低强度体外冲击波疗法的早期临床疗效,并探讨对磷酸二酯酶5型抑制剂(PDE5Is)有反应的中青年ED患者接受低强度体外冲击波疗法的相关因素:收集了61名曾对口服PDE5Is有反应的ED患者的数据,这些患者随后接受了Li-ESWT治疗。其中包括年龄、体重指数、睾丸总体积、性激素以及治疗前和治疗后1、3、6个月的IIEF-EF评分。治疗方案包括每周一次连续四周的治疗,每次治疗5000次冲击波脉冲。利用线性回归分析确定了与 Li-ESWT 疗效相关的因素。此外,还比较了不同严重程度的ED患者在治疗前后的改善情况以及他们的IIEF-EF评分:结果:Li-ESWT对PDE5Is有反应的中青年勃起功能障碍患者更有针对性,也更有效:入组患者的年龄从 22 岁到 53 岁不等,治疗后 1 个月、3 个月和 6 个月的 IIEF-EF 评分与基线进行了疗效评估比较,结果显示有显著改善(P t = -2.599,P = .013),并与基线 LH 水平呈正相关(t = 2.170,P = .036):临床意义:鉴于Li-ESWT治疗费用不菲且强调治疗的连续性,我们希望能确定最适合接受Li-ESWT治疗的患者,从而优化其应用:我们的研究结果为对PDE5Is有反应的非老年ED患者提供了更好的解决方案。本研究受样本量和随访时间的限制:结论:经过3个月的Li-ESWT治疗后,IIEF-EF评分逐渐趋于稳定,短期服用PDE5Is药物可提高患者对冲击波治疗的反应性。
{"title":"Retrospective analysis of the efficacy of low-intensity extracorporeal shock wave therapy on young and middle-aged patients with erectile dysfunction responsive to PDE5Is: reducing the use of PDE5Is.","authors":"Rui-Jie Yao, Mao-Yuan Wang, Qiang Chen, Hong Xiao, Peng Yang, Yi-Lang Ding, Xi Chen, Song-Xi Tang, Hui-Liang Zhou","doi":"10.1093/sexmed/qfae065","DOIUrl":"https://doi.org/10.1093/sexmed/qfae065","url":null,"abstract":"<p><strong>Background: </strong>Low-intensity extracorporeal shock wave therapy (Li-ESWT) is a new method for treating erectile dysfunction (ED), but there are no standards yet for its indications.</p><p><strong>Aim: </strong>The study aimed to suggest the early clinical efficacy of Li-ESWT and explore its related factors in young and middle-aged patients with ED who responded to phosphodiesterase type 5 Inhibitors (PDE5Is).</p><p><strong>Methods: </strong>Data from 61 patients with ED who had previously responded to oral PDE5Is and subsequently underwent Li-ESWT were collected. This included information on age, body mass index, total testicular volume, sex hormones, as well as IIEF-EF scores before treatment and at 1, 3, and 6 months after treatment. The treatment regimen involves a weekly session for four consecutive weeks, with each session administering 5000 shock wave pulses. Linear regression analysis was utilized to identify factors associated with the efficacy of Li-ESWT treatment. Additionally, the improvement in different severity groups of ED before and after treatment, along with their IIEF-EF scores, was compared.</p><p><strong>Outcomes: </strong>Li-ESWT was more targeted and effective for young and middle-aged patients with erectile dysfunction who responded to PDE5Is.</p><p><strong>Results: </strong>The age of enrolled patients ranges from 22 to 53 years old, and the IIEF-EF scores at 1 month, 3 months, and 6 months after treatment were compared to baseline for efficacy assessment, showing significant improvements (<i>P</i> < .0001) in all instances. Linear regression analysis using baseline data revealed predictive factors associated with treatment efficacy: treatment efficacy was negatively correlated with baseline IIEF-EF scores (<i>t</i> = -2.599, <i>P</i> = .013) and positively correlated with baseline LH levels (<i>t</i> = 2.170, <i>P</i> = .036).</p><p><strong>Clinical implications: </strong>Given the considerable cost of Li-ESWT treatment and the emphasis on treatment continuity, we hope to identify the most suitable candidates for Li-ESWT therapy, thereby optimizing its application.</p><p><strong>Strengths and limitations: </strong>Our findings provide a better solution for nonelderly ED patients who are responsive to PDE5Is. This study was limited by our sample size and follow-up time.</p><p><strong>Conclusion: </strong>After 3 months of Li-ESWT, the IIEF-EF score gradually stabilizes and short-term maintenance of PDE5Is medication increases the responsiveness to shock wave therapy.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae065"},"PeriodicalIF":2.6,"publicationDate":"2024-09-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11438993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Correction to: Letter to the Editor on "Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study". 更正:致编辑的信 "前列腺疾病、肾脏疾病、肾功能和勃起功能障碍风险之间的因果关系:一项双样本孟德尔随机研究"。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-24 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae069

[This corrects the article DOI: 10.1093/sexmed/qfae058.].

[此处更正了文章 DOI:10.1093/sexmed/qfae058]。
{"title":"Correction to: Letter to the Editor on \"Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study\".","authors":"","doi":"10.1093/sexmed/qfae069","DOIUrl":"https://doi.org/10.1093/sexmed/qfae069","url":null,"abstract":"<p><p>[This corrects the article DOI: 10.1093/sexmed/qfae058.].</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae069"},"PeriodicalIF":2.6,"publicationDate":"2024-09-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11420333/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142353392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The urinary and sexual outcomes of buccal mucosal graft urethroplasty versus end-to-end anastomosis: a systematic review with meta-analysis. 颊粘膜移植尿道成形术与端对端吻合术的泌尿和性功能结果:系统回顾与荟萃分析。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-21 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae064
Xingming Zhao, Qiang Guo, Xi Zhang, Qi Xing, Sheng Ren, Yuting Song, Chengyong Li, Chuan Hao, Jingqi Wang

Background: The urinary and sexual outcomes after urethroplasty may be a concern for patients, but there are still some controversies regarding the consequences of buccal mucosal graft urethroplasty (BMG) in terms of erectile dysfunction (ED).

Aim: This meta-analysis aimed to compare urinary and sexual outcomes of BMG and end-to-end urethroplasty (EE).

Methods: The PubMed, Web of Science, Cochrane, and Embase databases were searched until February 31, 2023. Data extraction and quality assessment were performed by 2 designated researchers. Dichotomous data were analyzed as odds ratios with 95% confidence intervals (CIs). Heterogeneity across studies was assessed by the I2 quantification, and publication bias using Begg's and Egger's tests. Meta-analysis was performed using RevMan software.

Outcomes: Outcomes included stricture recurrence, ED, penile complications, and voiding symptoms.

Results: Eighteen studies, including 1648 participants, were included in our meta-analysis. The meta-analysis revealed that there was no significant difference in stricture recurrence (OR = 0.74; 95% CI, 0.48-1.13; P = .17) and voiding symptoms (OR = 1.12; 95% CI, 0.32-3.88; P = .86) between the BMG group and the EE group. BMG was associated with lower risk of penile complications (OR = 0.40; 95% CI, 0.24-0.69; P = .001) and ED (OR = 0.53, 95% CI, 0.32-0.90, P = .02).

Clinical implications: The study may help clinicians choose procedures that achieve better recovery of the urological and sexual function in the treatment of urethral stricture.

Strengths and limitations: This meta-analysis is the first to evaluate the urinary and sexual outcomes of BMG vs EE. A limitation is that most of the included studies were retrospective cohort studies.

Conclusion: BMG is as effective as EE in the treatment of bulbar urethral stricture, but BMG has fewer complications and ED than EE.

背景:尿道成形术后的排尿和性功能结果可能是患者关心的问题,但关于颊粘膜移植尿道成形术(BMG)在勃起功能障碍(ED)方面的后果仍存在一些争议。目的:本荟萃分析旨在比较BMG和端对端尿道成形术(EE)的排尿和性功能结果:方法:对PubMed、Web of Science、Cochrane和Embase数据库进行检索,直至2023年2月31日。数据提取和质量评估由两名指定研究人员完成。二分法数据以带有 95% 置信区间 (CI) 的几率比进行分析。研究间的异质性通过 I2 量化进行评估,发表偏倚通过 Begg's 和 Egger's 检验进行评估。使用RevMan软件进行Meta分析:结果:结果包括狭窄复发、ED、阴茎并发症和排尿症状:我们的荟萃分析共纳入了 18 项研究,包括 1648 名参与者。荟萃分析表明,BMG 组和 EE 组在狭窄复发(OR = 0.74;95% CI,0.48-1.13;P = .17)和排尿症状(OR = 1.12;95% CI,0.32-3.88;P = .86)方面无显著差异。BMG与较低的阴茎并发症风险(OR = 0.40; 95% CI, 0.24-0.69; P = .001)和ED(OR = 0.53, 95% CI, 0.32-0.90, P = .02)相关:该研究可帮助临床医生在治疗尿道狭窄时选择能更好地恢复泌尿系统和性功能的手术:这项荟萃分析首次评估了BMG与EE的泌尿和性功能结果。局限性在于纳入的大多数研究都是回顾性队列研究:结论:在治疗球部尿道狭窄方面,BMG 与 EE 同样有效,但 BMG 比 EE 的并发症和 ED 更少。
{"title":"The urinary and sexual outcomes of buccal mucosal graft urethroplasty versus end-to-end anastomosis: a systematic review with meta-analysis.","authors":"Xingming Zhao, Qiang Guo, Xi Zhang, Qi Xing, Sheng Ren, Yuting Song, Chengyong Li, Chuan Hao, Jingqi Wang","doi":"10.1093/sexmed/qfae064","DOIUrl":"10.1093/sexmed/qfae064","url":null,"abstract":"<p><strong>Background: </strong>The urinary and sexual outcomes after urethroplasty may be a concern for patients, but there are still some controversies regarding the consequences of buccal mucosal graft urethroplasty (BMG) in terms of erectile dysfunction (ED).</p><p><strong>Aim: </strong>This meta-analysis aimed to compare urinary and sexual outcomes of BMG and end-to-end urethroplasty (EE).</p><p><strong>Methods: </strong>The PubMed, Web of Science, Cochrane, and Embase databases were searched until February 31, 2023. Data extraction and quality assessment were performed by 2 designated researchers. Dichotomous data were analyzed as odds ratios with 95% confidence intervals (CIs). Heterogeneity across studies was assessed by the I<sup>2</sup> quantification, and publication bias using Begg's and Egger's tests. Meta-analysis was performed using RevMan software.</p><p><strong>Outcomes: </strong>Outcomes included stricture recurrence, ED, penile complications, and voiding symptoms.</p><p><strong>Results: </strong>Eighteen studies, including 1648 participants, were included in our meta-analysis. The meta-analysis revealed that there was no significant difference in stricture recurrence (OR = 0.74; 95% CI, 0.48-1.13; <i>P</i> = .17) and voiding symptoms (OR = 1.12; 95% CI, 0.32-3.88; <i>P</i> = .86) between the BMG group and the EE group. BMG was associated with lower risk of penile complications (OR = 0.40; 95% CI, 0.24-0.69; <i>P</i> = .001) and ED (OR = 0.53, 95% CI, 0.32-0.90, <i>P</i> = .02).</p><p><strong>Clinical implications: </strong>The study may help clinicians choose procedures that achieve better recovery of the urological and sexual function in the treatment of urethral stricture.</p><p><strong>Strengths and limitations: </strong>This meta-analysis is the first to evaluate the urinary and sexual outcomes of BMG vs EE. A limitation is that most of the included studies were retrospective cohort studies.</p><p><strong>Conclusion: </strong>BMG is as effective as EE in the treatment of bulbar urethral stricture, but BMG has fewer complications and ED than EE.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae064"},"PeriodicalIF":2.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416911/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization study. 基于贝叶斯法的 731 个免疫细胞与勃起功能障碍之间的因果关系分析:一项双样本、双向和多变量孟德尔随机化研究。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-21 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae062
Junhao Chen, Yidao Liu, Peiqin Zhan, Tianci Gao, Jieming Zuo, Xiangyun Li, Fangfei Zhang, Haifeng Wang, Shi Fu

Background: The causal relationship between certain immune cells and erectile dysfunction (ED) is still uncertain.

Aim: The study sought to investigate the causal effect of 731 types of immune cells on ED through Mendelian randomization (MR) using genome-wide association studies (GWAS).

Methods: Genetic instruments for 731 immune cells were identified through GWAS, and ED data were obtained from the FinnGen database. Univariable and multivariable bidirectional MR studies were conducted to explore potential causal relationships between these immune cells and ED. The inverse-variance weighted method was primarily used, with Cochran's Q test and MR-Egger intercept test assessing pleiotropy and heterogeneity. Bayesian weighted Mendelian randomization (BWMR) was also employed.

Outcomes: Six immune cells were identified as related to ED. CD45 on Natural Killer (NK) cells, CD33dim HLA DR+ CD11b + Absolute Count, CD19 on IgD- CD38dim B cells, and CD3 on CD39+ resting CD4 regulatory T cells were identified as risk factors, whereas CD20 on IgD+ CD38dim B cells and Activated & resting CD4 regulatory T cell %CD4+ T cells were protective factors. Further multivariable MR analysis confirmed that 5 of these immune cells independently impacted ED, except for CD45 on NK cells. Reverse MR analysis indicated that ED occurrence decreases certain immune cell counts, but BWMR found no causal relationship for CD20 on IgD+ CD38dim B cells.

Results: Our MR analysis confirmed a potential bidirectional causal relationship between immune cells and ED, providing new insights into potential mechanisms and therapeutic strategies.

Clinical translation: This study provides evidence for the impact of certain immune cells on the development of ED and suggests potential therapeutic targets.

Strengths and limitations: We performed both univariable and multivariable MR to strengthen the causal relationship between exposures and outcomes. However, the population in this study was limited to European ancestry.

Conclusion: Our MR analysis confirmed a potential bidirectional causal relationship between immune cells and ED. This provides new insights into potential mechanisms of pathogenesis and subsequent therapeutic strategies.

背景:某些免疫细胞与勃起功能障碍(ED)之间的因果关系尚不确定:目的:该研究试图利用全基因组关联研究(GWAS),通过孟德尔随机化(MR)研究731种免疫细胞对ED的因果关系:方法:通过全基因组关联研究(GWAS)确定了 731 种免疫细胞的遗传工具,并从 FinnGen 数据库中获得了 ED 数据。为了探索这些免疫细胞与 ED 之间的潜在因果关系,我们进行了单变量和多变量双向 MR 研究。研究主要采用逆方差加权法,并通过科克伦 Q 检验和 MR-Egger 截距检验来评估多变性和异质性。此外还采用了贝叶斯加权孟德尔随机法(BWMR):确定了六种与 ED 相关的免疫细胞。自然杀伤(NK)细胞上的 CD45、CD33dim HLA DR+ CD11b + Absolute Count、IgD- CD38dim B 细胞上的 CD19 和 CD39+ 静止 CD4 调节性 T 细胞上的 CD3 被确定为风险因素,而 IgD+ CD38dim B 细胞上的 CD20 和活化及静止 CD4 调节性 T 细胞 %CD4+ T 细胞则是保护因素。进一步的多变量磁共振分析证实,除 NK 细胞上的 CD45 外,上述 5 种免疫细胞对 ED 均有独立影响。反向 MR 分析表明,ED 的发生会降低某些免疫细胞的数量,但 BWMR 发现 IgD+ CD38dim B 细胞上的 CD20 与此无关:我们的磁共振分析证实了免疫细胞与 ED 之间潜在的双向因果关系,为潜在机制和治疗策略提供了新的见解:临床转化:这项研究为某些免疫细胞对 ED 的发展产生影响提供了证据,并提出了潜在的治疗靶点:我们进行了单变量和多变量磁共振分析,以加强暴露与结果之间的因果关系。然而,这项研究的人群仅限于欧洲血统:我们的磁共振分析证实了免疫细胞与 ED 之间潜在的双向因果关系。结论:我们的磁共振分析证实了免疫细胞与 ED 之间潜在的双向因果关系,这为潜在的发病机制和后续治疗策略提供了新的视角。
{"title":"Bayesian-based analysis of the causality between 731 immune cells and erectile dysfunction: a two-sample, bidirectional, and multivariable Mendelian randomization study.","authors":"Junhao Chen, Yidao Liu, Peiqin Zhan, Tianci Gao, Jieming Zuo, Xiangyun Li, Fangfei Zhang, Haifeng Wang, Shi Fu","doi":"10.1093/sexmed/qfae062","DOIUrl":"10.1093/sexmed/qfae062","url":null,"abstract":"<p><strong>Background: </strong>The causal relationship between certain immune cells and erectile dysfunction (ED) is still uncertain.</p><p><strong>Aim: </strong>The study sought to investigate the causal effect of 731 types of immune cells on ED through Mendelian randomization (MR) using genome-wide association studies (GWAS).</p><p><strong>Methods: </strong>Genetic instruments for 731 immune cells were identified through GWAS, and ED data were obtained from the FinnGen database. Univariable and multivariable bidirectional MR studies were conducted to explore potential causal relationships between these immune cells and ED. The inverse-variance weighted method was primarily used, with Cochran's Q test and MR-Egger intercept test assessing pleiotropy and heterogeneity. Bayesian weighted Mendelian randomization (BWMR) was also employed.</p><p><strong>Outcomes: </strong>Six immune cells were identified as related to ED. CD45 on Natural Killer (NK) cells, CD33dim HLA DR+ CD11b + Absolute Count, CD19 on IgD- CD38dim B cells, and CD3 on CD39+ resting CD4 regulatory T cells were identified as risk factors, whereas CD20 on IgD+ CD38dim B cells and Activated & resting CD4 regulatory T cell %CD4+ T cells were protective factors. Further multivariable MR analysis confirmed that 5 of these immune cells independently impacted ED, except for CD45 on NK cells. Reverse MR analysis indicated that ED occurrence decreases certain immune cell counts, but BWMR found no causal relationship for CD20 on IgD+ CD38dim B cells.</p><p><strong>Results: </strong>Our MR analysis confirmed a potential bidirectional causal relationship between immune cells and ED, providing new insights into potential mechanisms and therapeutic strategies.</p><p><strong>Clinical translation: </strong>This study provides evidence for the impact of certain immune cells on the development of ED and suggests potential therapeutic targets.</p><p><strong>Strengths and limitations: </strong>We performed both univariable and multivariable MR to strengthen the causal relationship between exposures and outcomes. However, the population in this study was limited to European ancestry.</p><p><strong>Conclusion: </strong>Our MR analysis confirmed a potential bidirectional causal relationship between immune cells and ED. This provides new insights into potential mechanisms of pathogenesis and subsequent therapeutic strategies.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae062"},"PeriodicalIF":2.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416910/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308513","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Effectiveness of low dose cyproterone acetate compared to standard dose in feminizing hormone treatment: a single institutional retrospective pilot study. 在女性化激素治疗中,低剂量醋酸环丙孕酮与标准剂量的疗效比较:一项单一机构回顾性试验研究。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-21 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae063
Sira Korpaisarn, Jiraporn Arunakul, Kewalin Chaisuksombat, Teerapong Rattananukrom

Background: Data regarding the effectiveness of low-dose cyproterone acetate (CPA) in testosterone suppression as feminizing hormone therapy (FHT) in individuals assigned male at birth (AMAB) are sparse.

Aim: To assess the effectiveness in testosterone suppression using low-dose CPA (<25 mg/day) compared to standard-dose CPA (25-50 mg/day) in FHT.

Methods: A retrospective cohort study of 59 individuals AMAB using CPA was done at a tertiary care center in Bangkok, Thailand between January 2014 and July 2022.

Outcomes: The main outcomes included a median time when the testosterone was suppressed (<50 ng/dL), the proportion of individuals AMAB who achieved the targeted testosterone level at 3 months, and the testosterone level at each follow-up. Changes in clinical data were assessed.

Results: Among 59 individuals AMAB, 37 initiated CPA with available testosterone levels at the 3-month follow-up. Twenty-two individuals AMAB started with low-dose CPA (12.5 mg/day), and 15 individuals AMAB started with standard-dose CPA. The median time to reach targeted testosterone was 3 months in both groups (adjusted hazard ratio 0.60, P = .489). At 3 months, 72.7% of those on low-dose CPA and 86.7% of those on standard-dose CPA achieved targeted testosterone (adjusted relative risk 0.85, P = .606). Testosterone levels at all follow-up visits were not significantly different. The standard dose group had higher high-density lipoprotein cholesterol (HDL-C) but lower low-density lipoprotein cholesterol (LDL-C) and alanine aminotransferase (ALT).

Clinical translation: This study supports a paradigm shift toward using lower-dose CPA in FHT.

Strengths and limitations: This is one of a few studies showing the effectiveness of low-dose CPA in testosterone suppression within 3 months. Limitations include a small sample size and missing data.

Conclusions: Testosterone suppression is comparable between CPA 12.5 mg/day and the standard dose in FHT.

背景:有关低剂量醋酸环丙孕酮(CPA)作为女性化激素疗法(FHT)抑制出生时即被指派为男性的个体(AMAB)睾酮的有效性的数据很少:2014年1月至2022年7月期间,泰国曼谷的一家三级医疗中心对59名使用CPA的AMAB患者进行了一项回顾性队列研究:主要结果包括睾酮被抑制的中位时间(结果:在 59 名 AMAB 患者中,37 人开始接受 CPA 治疗,3 个月随访时睾酮水平尚可。22名AMAB患者开始使用低剂量CPA(12.5毫克/天),15名AMAB患者开始使用标准剂量CPA。两组达到目标睾酮的中位时间均为 3 个月(调整后危险比为 0.60,P = .489)。3 个月后,72.7% 的低剂量 CPA 患者和 86.7% 的标准剂量 CPA 患者达到了目标睾酮水平(调整后相对风险为 0.85,P = 0.606)。所有随访的睾酮水平均无显著差异。标准剂量组的高密度脂蛋白胆固醇(HDL-C)较高,但低密度脂蛋白胆固醇(LDL-C)和丙氨酸氨基转移酶(ALT)较低:这项研究支持了在 FHT 中使用低剂量 CPA 的模式转变:这是少数几项显示低剂量 CPA 在 3 个月内有效抑制睾酮的研究之一。局限性包括样本量小和数据缺失:睾酮抑制效果在12.5毫克/天的CPA和标准剂量的FHT中不相上下。
{"title":"Effectiveness of low dose cyproterone acetate compared to standard dose in feminizing hormone treatment: a single institutional retrospective pilot study.","authors":"Sira Korpaisarn, Jiraporn Arunakul, Kewalin Chaisuksombat, Teerapong Rattananukrom","doi":"10.1093/sexmed/qfae063","DOIUrl":"10.1093/sexmed/qfae063","url":null,"abstract":"<p><strong>Background: </strong>Data regarding the effectiveness of low-dose cyproterone acetate (CPA) in testosterone suppression as feminizing hormone therapy (FHT) in individuals assigned male at birth (AMAB) are sparse.</p><p><strong>Aim: </strong>To assess the effectiveness in testosterone suppression using low-dose CPA (<25 mg/day) compared to standard-dose CPA (25-50 mg/day) in FHT.</p><p><strong>Methods: </strong>A retrospective cohort study of 59 individuals AMAB using CPA was done at a tertiary care center in Bangkok, Thailand between January 2014 and July 2022.</p><p><strong>Outcomes: </strong>The main outcomes included a median time when the testosterone was suppressed (<50 ng/dL), the proportion of individuals AMAB who achieved the targeted testosterone level at 3 months, and the testosterone level at each follow-up. Changes in clinical data were assessed.</p><p><strong>Results: </strong>Among 59 individuals AMAB, 37 initiated CPA with available testosterone levels at the 3-month follow-up. Twenty-two individuals AMAB started with low-dose CPA (12.5 mg/day), and 15 individuals AMAB started with standard-dose CPA. The median time to reach targeted testosterone was 3 months in both groups (adjusted hazard ratio 0.60, <i>P</i> = .489). At 3 months, 72.7% of those on low-dose CPA and 86.7% of those on standard-dose CPA achieved targeted testosterone (adjusted relative risk 0.85, <i>P</i> = .606). Testosterone levels at all follow-up visits were not significantly different. The standard dose group had higher high-density lipoprotein cholesterol (HDL-C) but lower low-density lipoprotein cholesterol (LDL-C) and alanine aminotransferase (ALT).</p><p><strong>Clinical translation: </strong>This study supports a paradigm shift toward using lower-dose CPA in FHT.</p><p><strong>Strengths and limitations: </strong>This is one of a few studies showing the effectiveness of low-dose CPA in testosterone suppression within 3 months. Limitations include a small sample size and missing data.</p><p><strong>Conclusions: </strong>Testosterone suppression is comparable between CPA 12.5 mg/day and the standard dose in FHT.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae063"},"PeriodicalIF":2.6,"publicationDate":"2024-09-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11416909/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142308514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sexual difficulties in men who have sex with men living with HIV: their mental health and health-related quality of life. 感染艾滋病毒的男男性行为者的性障碍:他们的心理健康和与健康相关的生活质量。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-20 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae060
Yuyuan Xu, Xiaoli Lin, Xiaoxuan Wu, Hongjie Chen, Xuwen Xu, Yuanhui Jiang, Suling Chen, Bing Li, Huiqun Zhong, Shaohang Cai
<p><strong>Background: </strong>Health-related quality of life (HRQoL) is gaining significance for people living with human immunodeficiency virus (HIV), with sexual difficulties being a crucial yet frequently neglected component of HRQoL, especially in HIV-positive men who have sex with men (MSM).</p><p><strong>Aim: </strong>The study sought to assess the levels of sexual difficulties and explore the associations between sexual difficulties, mental health, and HRQoL in HIV-positive MSM.</p><p><strong>Methods: </strong>A cohort of 475 HIV-positive MSM was studied from January 2017 to December 2021. Sociodemographic, clinical, and lifestyle data were collected. Participants were divided based on Arizona Sexual Experience Scale (ASEX) scores into 2 groups: those with sexual difficulties and a control group without difficulties.</p><p><strong>Outcomes: </strong>Psychological symptoms were evaluated by the Symptom Checklist-90 (SCL-90), HRQoL was accessed via 36-item Short Form Health Survey, and sexual function was assessed using the ASEX. We also employed path analysis to unveil latent mechanisms, alongside multivariate analysis to identify independent factors, and aimed to elucidate the interplay among sexual function, HRQoL, and mental health in HIV-positive MSM.</p><p><strong>Results: </strong>A total of 391 HIV-positive MSM were enrolled in the control group and 84 in the sexual difficulties group. The control group had significantly higher physical HRQoL (<i>P =</i> .004) and mental HRQoL (<i>P =</i> .045). In addition, SCL-90 scores were higher in the sexual difficulties group (<i>P =</i> .001). Multivariate analyses that indicated regular exercise (odds ratio, 0.553; <i>P =</i> .024) and alcohol consumption (odds ratio, 1.780; <i>P =</i> .033) were independent factors associated with sexual difficulties. The proportion of alcohol consumption in the sexual difficulties group was significantly higher (<i>P =</i> .003). ASEX scores increased gradually with increasing frequency of alcohol consumption (<i>P =</i> .031). Results from structural equation model showed a negative association between HRQoL and ASEX scores (β = -0.13, <i>P</i> < .001) and SCL-90 scores (β = -0.40, <i>P</i> < .001).</p><p><strong>Clinical implications: </strong>HIV-positive MSM experiencing sexual difficulties exhibited lower HRQoL and worse mental health, with independent associations identified for regular exercise and alcohol consumption in relation to sexual difficulties.</p><p><strong>Strengths and limitations: </strong>Our research has pioneered in demonstrating that HRQoL mediates the relationship between sexual difficulties and psychological symptoms among HIV-positive MSM undergoing highly active antiretroviral therapy. We found the protective factor associated with sexual difficulties was regular exercise while the risk factor was alcohol consumption. However, the data were collected only from China, and it is still unclear how HRQoL changes after intervention
背景:与健康相关的生活质量(HRQoL)对于人类免疫缺陷病毒(HIV)感染者来说越来越重要,而性生活困难是HRQoL中一个重要但却经常被忽视的组成部分,尤其是在HIV阳性男男性行为者(MSM)中。目的:该研究旨在评估HIV阳性MSM的性生活困难程度,并探讨性生活困难、心理健康和HRQoL之间的关联:从 2017 年 1 月至 2021 年 12 月,对 475 名 HIV 阳性 MSM 进行了队列研究。研究收集了社会人口学、临床和生活方式数据。根据亚利桑那性体验量表(ASEX)的评分将参与者分为两组:有性困难的组和没有性困难的对照组:结果:心理症状通过症状检查表-90(SCL-90)进行评估,HRQoL通过36项简表健康调查获得,性功能通过ASEX进行评估。我们还采用了路径分析来揭示潜在机制,并通过多变量分析来确定独立因素,旨在阐明 HIV 阳性 MSM 的性功能、HRQoL 和心理健康之间的相互作用:共有 391 名 HIV 阳性 MSM 被纳入对照组,84 名被纳入性困难组。对照组的身体 HRQoL(P = .004)和心理 HRQoL(P = .045)明显高于对照组。此外,性困难组的 SCL-90 评分更高(P = .001)。多变量分析表明,经常锻炼(几率比,0.553;P = .024)和饮酒(几率比,1.780;P = .033)是与性生活困难相关的独立因素。性生活困难组的饮酒比例明显更高(P = .003)。随着饮酒频率的增加,ASEX 分数也逐渐增加(P = .031)。结构方程模型的结果显示,HRQoL 与 ASEX 分数之间存在负相关(β = -0.13,P = 0.003):性生活困难的 HIV 阳性 MSM 表现出较低的 HRQoL 和较差的心理健康,定期锻炼和饮酒与性生活困难之间存在独立关联:我们的研究率先证明,在接受高活性抗逆转录病毒治疗的 HIV 阳性 MSM 患者中,HRQoL 是性困难与心理症状之间关系的中介。我们发现,与性困难相关的保护因素是经常锻炼,而风险因素是饮酒。然而,这些数据仅收集自中国,目前尚不清楚干预后 HRQoL 的变化情况:结论:对艾滋病病毒感染者的常规随访应包括对性功能的调查,强调及时评估和干预的必要性,尤其是对具有已识别风险因素的艾滋病阳性男男性行为者。
{"title":"Sexual difficulties in men who have sex with men living with HIV: their mental health and health-related quality of life.","authors":"Yuyuan Xu, Xiaoli Lin, Xiaoxuan Wu, Hongjie Chen, Xuwen Xu, Yuanhui Jiang, Suling Chen, Bing Li, Huiqun Zhong, Shaohang Cai","doi":"10.1093/sexmed/qfae060","DOIUrl":"10.1093/sexmed/qfae060","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Health-related quality of life (HRQoL) is gaining significance for people living with human immunodeficiency virus (HIV), with sexual difficulties being a crucial yet frequently neglected component of HRQoL, especially in HIV-positive men who have sex with men (MSM).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Aim: &lt;/strong&gt;The study sought to assess the levels of sexual difficulties and explore the associations between sexual difficulties, mental health, and HRQoL in HIV-positive MSM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;A cohort of 475 HIV-positive MSM was studied from January 2017 to December 2021. Sociodemographic, clinical, and lifestyle data were collected. Participants were divided based on Arizona Sexual Experience Scale (ASEX) scores into 2 groups: those with sexual difficulties and a control group without difficulties.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcomes: &lt;/strong&gt;Psychological symptoms were evaluated by the Symptom Checklist-90 (SCL-90), HRQoL was accessed via 36-item Short Form Health Survey, and sexual function was assessed using the ASEX. We also employed path analysis to unveil latent mechanisms, alongside multivariate analysis to identify independent factors, and aimed to elucidate the interplay among sexual function, HRQoL, and mental health in HIV-positive MSM.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;A total of 391 HIV-positive MSM were enrolled in the control group and 84 in the sexual difficulties group. The control group had significantly higher physical HRQoL (&lt;i&gt;P =&lt;/i&gt; .004) and mental HRQoL (&lt;i&gt;P =&lt;/i&gt; .045). In addition, SCL-90 scores were higher in the sexual difficulties group (&lt;i&gt;P =&lt;/i&gt; .001). Multivariate analyses that indicated regular exercise (odds ratio, 0.553; &lt;i&gt;P =&lt;/i&gt; .024) and alcohol consumption (odds ratio, 1.780; &lt;i&gt;P =&lt;/i&gt; .033) were independent factors associated with sexual difficulties. The proportion of alcohol consumption in the sexual difficulties group was significantly higher (&lt;i&gt;P =&lt;/i&gt; .003). ASEX scores increased gradually with increasing frequency of alcohol consumption (&lt;i&gt;P =&lt;/i&gt; .031). Results from structural equation model showed a negative association between HRQoL and ASEX scores (β = -0.13, &lt;i&gt;P&lt;/i&gt; &lt; .001) and SCL-90 scores (β = -0.40, &lt;i&gt;P&lt;/i&gt; &lt; .001).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;HIV-positive MSM experiencing sexual difficulties exhibited lower HRQoL and worse mental health, with independent associations identified for regular exercise and alcohol consumption in relation to sexual difficulties.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;Our research has pioneered in demonstrating that HRQoL mediates the relationship between sexual difficulties and psychological symptoms among HIV-positive MSM undergoing highly active antiretroviral therapy. We found the protective factor associated with sexual difficulties was regular exercise while the risk factor was alcohol consumption. However, the data were collected only from China, and it is still unclear how HRQoL changes after intervention","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae060"},"PeriodicalIF":2.6,"publicationDate":"2024-09-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11413803/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294971","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
No bidirectional association between serum 25-hydroxyvitamin D and erectile dysfunction: Mendelian randomization and genetic association studies. 血清 25- 羟维生素 D 与勃起功能障碍之间没有双向关联:孟德尔随机化和遗传关联研究。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-19 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae061
Xiang Liu, Longhua Luo, Cong Peng, Zixin Wang, Jiaming Zhou, Xiang Sun

Background: The causal relationship between the level of serum 25-hydroxyvitamin D [25(OH)D] and the risk of erectile dysfunction (ED) is still unclear.

Aim: We tried to determine the causal relationship between the level of serum 25(OH)D and ED risk.

Methods: In this study, we used genome-wide association study data from the UK Biobank to analyse the relationship between serum 25(OH)D (as the exposure) and ED (as the outcome). Linkage disequilibrium score regression (LDSC) was used to assess the genetic correlation between 2 traits. The CAUSE (Causal Analysis using Summary Effect estimates) method and Mendelian randomization (MR) were employed to evaluate the bidirectional causal relationship. The MRlap method was utilized to assess the impact of sample overlap on the results. To assess potential heterogeneity and horizontal pleiotropy, we utilized methods such as MR-Egger, MR-PRESSO (Mendelian Randomization Pleiotropy Residual Sum and Outlier), weighted median, and others.

Outcomes: The primary outcome was defined as self or physician-reported ED, or using oral ED medication, or a history of surgery related to ED.

Results: The LDSC analysis did not reveal a significant genetic correlation between serum 25(OH)D and ED (rg = 0.2787, P = .3536). Additionally, the CAUSE (P value testing that the causal model is a better fit >.05) and MR analyses (odds ratio, 0.8951; 95% confidence interval, 0.7480-1.0710; P = .2260) did not support a causal relationship between 25(OH)D and ED, and our study did not detect any heterogeneity and pleiotropy.

Clinical implications: This study provides evidence on whether vitamin D needs to be ingested to prevent or treat ED.

Strengths and limitations: We used LDSC and MR to avoid bias. However, the population in this study was limited to European ancestry.

Conclusion: No causal relationship was found between 25(OH)D and ED.

背景:目的:我们试图确定血清25-羟基维生素D[25(OH)D]水平与勃起功能障碍(ED)风险之间的因果关系:在这项研究中,我们利用英国生物库(UK Biobank)的全基因组关联研究数据分析了血清 25(OH)D(作为暴露量)与 ED(作为结果)之间的关系。链接不平衡得分回归(LDSC)用于评估两个性状之间的遗传相关性。采用 CAUSE(使用摘要效应估计的因果分析)方法和孟德尔随机化(MR)来评估双向因果关系。MRlap 方法用于评估样本重叠对结果的影响。为了评估潜在的异质性和水平褶皱,我们采用了 MR-Egger、MR-PRESSO(孟德尔随机褶皱残差和离群值)、加权中位数等方法:主要结果定义为自我或医生报告的 ED,或使用口服 ED 药物,或与 ED 相关的手术史:LDSC分析未发现血清25(OH)D与ED之间存在显著的遗传相关性(rg = 0.2787,P = .3536)。此外,CAUSE分析(检验因果模型拟合度更高的P值>.05)和MR分析(几率比0.8951;95%置信区间0.7480-1.0710;P = .2260)也不支持25(OH)D与ED之间存在因果关系,而且我们的研究没有检测到任何异质性和多义性:本研究为预防或治疗 ED 是否需要摄入维生素 D 提供了证据:我们使用了LDSC和MR以避免偏倚。然而,本研究的人群仅限于欧洲血统:结论:25(OH)D与ED之间没有因果关系。
{"title":"No bidirectional association between serum 25-hydroxyvitamin D and erectile dysfunction: Mendelian randomization and genetic association studies.","authors":"Xiang Liu, Longhua Luo, Cong Peng, Zixin Wang, Jiaming Zhou, Xiang Sun","doi":"10.1093/sexmed/qfae061","DOIUrl":"10.1093/sexmed/qfae061","url":null,"abstract":"<p><strong>Background: </strong>The causal relationship between the level of serum 25-hydroxyvitamin D [25(OH)D] and the risk of erectile dysfunction (ED) is still unclear.</p><p><strong>Aim: </strong>We tried to determine the causal relationship between the level of serum 25(OH)D and ED risk.</p><p><strong>Methods: </strong>In this study, we used genome-wide association study data from the UK Biobank to analyse the relationship between serum 25(OH)D (as the exposure) and ED (as the outcome). Linkage disequilibrium score regression (LDSC) was used to assess the genetic correlation between 2 traits. The CAUSE (Causal Analysis using Summary Effect estimates) method and Mendelian randomization (MR) were employed to evaluate the bidirectional causal relationship. The MRlap method was utilized to assess the impact of sample overlap on the results. To assess potential heterogeneity and horizontal pleiotropy, we utilized methods such as MR-Egger, MR-PRESSO (Mendelian Randomization Pleiotropy Residual Sum and Outlier), weighted median, and others.</p><p><strong>Outcomes: </strong>The primary outcome was defined as self or physician-reported ED, or using oral ED medication, or a history of surgery related to ED.</p><p><strong>Results: </strong>The LDSC analysis did not reveal a significant genetic correlation between serum 25(OH)D and ED (r<sub>g</sub> = 0.2787, <i>P =</i> .3536). Additionally, the CAUSE (<i>P</i> value testing that the causal model is a better fit >.05) and MR analyses (odds ratio, 0.8951; 95% confidence interval, 0.7480-1.0710; <i>P =</i> .2260) did not support a causal relationship between 25(OH)D and ED, and our study did not detect any heterogeneity and pleiotropy.</p><p><strong>Clinical implications: </strong>This study provides evidence on whether vitamin D needs to be ingested to prevent or treat ED.</p><p><strong>Strengths and limitations: </strong>We used LDSC and MR to avoid bias. However, the population in this study was limited to European ancestry.</p><p><strong>Conclusion: </strong>No causal relationship was found between 25(OH)D and ED.</p>","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae061"},"PeriodicalIF":2.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411456/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294955","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Peripheral pathway gene variants in lifelong premature ejaculation: CYP19A1, CYP1A1, and CYP1A2 enzymes polymorphisms in Chinese Han men. 终生早泄的外周通路基因变异:中国汉族男性CYP19A1、CYP1A1和CYP1A2酶的多态性。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-19 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae056
Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jiangbing Xu, Meng Yang, Cun Zhou, Rui Li, Shaowei Mo, Liying Zhuang, Weifu Wang
<p><strong>Background: </strong>Recent genetic association studies focusing on central pathways have been performed to investigate the correlation between susceptibility alleles and the risk of lifelong premature ejaculation (LPE). However, there remains a dearth of documented genes associated with peripheral pathways.</p><p><strong>Objective: </strong>In this study we aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) associated with the peripheral genes <i>CYP19A1</i>, <i>CYP1A1</i>, and <i>CYP1A2</i> and the risk of LPE.</p><p><strong>Methods: </strong>From August 2017 to August 2020, a total of 511 participants (139 LPE patients and 372 controls) were recruited. Trained medical professionals diagnosed LPE according to the standard definition set by the International Society for Sexual Medicine. Nine candidate SNPs were chosen and genotyped using the MassARRAY system. Allele and genotype frequencies of the SNPs among patients and controls were compared using the χ<sup>2</sup> test. Logistic regression analysis, adjusted for age, was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) using PLINK version 1.9. Haploview software was employed to analyze linkage disequilibrium and haplotype distribution. The interaction among candidate SNPs concerning LPE risk was evaluated using multifactor dimensionality reduction. The relationship between selected polymorphisms and specific features was assessed using analysis of variance.</p><p><strong>Outcome: </strong>Heterozygous SNPs located in the <i>CYP19A1</i> (rs4646, rs17601876), <i>CYP1A1</i> (rs1048943), and <i>CYP1A2</i> (rs762551, rs2470890) genes showed significant correlations with the risk of LPE.</p><p><strong>Results: </strong>The findings of this study confirmed that heterozygous SNPs in the <i>CYP19A1</i> (rs4646 AC vs CC: OR, 1.84; CI, 1.10-3.09; rs17601876 AG vs GG: OR, 1.80; CI, 1.06-3.05) and <i>CYP1A1</i> genes (rs1048943 CT vs TT: OR, 1.71; CI, 1.02-2.87), respectively, can significantly increase the LPE risk. Participant scores for the Premature Ejaculation Diagnostic Tool (<i>P</i> =.002) and International Index of Erectile Function-5 (<i>P</i> =.020) differed significantly by genotype for the different genotypes of <i>CYP1A1</i>-rs1048943. Haplotype analysis revealed strong linkage disequilibrium under <i>CYP1A2</i>_rs762551-rs2470890 (D' = 1.00).</p><p><strong>Clinical implications: </strong>The findings of this and other investigations of genetic determinants and potential pathogenic mechanisms of LPE may advance diagnostic and therapeutic opportunities in LPE patients.</p><p><strong>Strengths and limitations: </strong>In this study of LPE in men with CYP gene variants we addressed a current research gap. However, data on risk factors such as smoking and drinking were incomplete in both the case and control groups. In future studies we will expand the sample size and enhance data on risk factors for more precise assessment
背景:最近开展的遗传关联研究侧重于中心通路,以调查易感等位基因与终身早泄(LPE)风险之间的相关性。然而,与外周通路相关的基因仍然缺乏记录:在这项研究中,我们旨在调查与外周基因 CYP19A1、CYP1A1 和 CYP1A2 相关的单核苷酸多态性(SNPs)与 LPE 风险之间的关系:从 2017 年 8 月至 2020 年 8 月,共招募了 511 名参与者(139 名 LPE 患者和 372 名对照者)。经过培训的专业医务人员根据国际性医学会制定的标准定义对 LPE 进行诊断。研究人员选择了 9 个候选 SNPs,并使用 MassARRAY 系统进行了基因分型。使用 χ2 检验比较了患者和对照组中 SNPs 的等位基因和基因型频率。使用 PLINK 1.9 版进行逻辑回归分析,并对年龄进行调整,以计算几率比(ORs)和 95% 置信区间(CIs)。Haploview 软件用于分析连锁不平衡和单倍型分布。使用多因素降维法评估了候选 SNPs 之间关于 LPE 风险的相互作用。利用方差分析评估了所选多态性与特定特征之间的关系:位于 CYP19A1(rs4646、rs17601876)、CYP1A1(rs1048943)和 CYP1A2(rs762551、rs2470890)基因中的杂合 SNP 与 LPE 风险有显著相关性:本研究结果证实,CYP19A1(rs4646 AC vs CC:OR,1.84;CI,1.10-3.09;rs17601876 AG vs GG:OR,1.80;CI,1.06-3.05)和 CYP1A1 基因(rs1048943 CT vs TT:OR,1.71;CI,1.02-2.87)中的杂合 SNPs 可显著增加 LPE 风险。不同基因型的 CYP1A1-rs1048943 参与者在早泄诊断工具(P =.002)和国际勃起功能指数-5(International Index of Erectile Function-5,P =.020)方面的得分有明显差异。单倍型分析表明,CYP1A2_rs762551-rs2470890(D' = 1.00)具有很强的连锁不平衡:本研究及其他关于 LPE 遗传决定因素和潜在致病机制的研究结果可为 LPE 患者的诊断和治疗提供更多机会:在这项关于CYP基因变异男性LPE的研究中,我们填补了目前的研究空白。然而,病例组和对照组中有关吸烟和饮酒等风险因素的数据并不完整。在今后的研究中,我们将扩大样本量,增加有关风险因素的数据,以进行更精确的评估:总之,外周基因 CYP19A1、CYP1A1 和 CYP1A2 的多态性可能是导致中国汉族男性 LPE 的原因之一。
{"title":"Peripheral pathway gene variants in lifelong premature ejaculation: CYP19A1, CYP1A1, and CYP1A2 enzymes polymorphisms in Chinese Han men.","authors":"Fei Wang, Defan Luo, Jianxiang Chen, Cuiqing Pan, Zhongyao Wang, Housheng Fu, Jiangbing Xu, Meng Yang, Cun Zhou, Rui Li, Shaowei Mo, Liying Zhuang, Weifu Wang","doi":"10.1093/sexmed/qfae056","DOIUrl":"https://doi.org/10.1093/sexmed/qfae056","url":null,"abstract":"&lt;p&gt;&lt;strong&gt;Background: &lt;/strong&gt;Recent genetic association studies focusing on central pathways have been performed to investigate the correlation between susceptibility alleles and the risk of lifelong premature ejaculation (LPE). However, there remains a dearth of documented genes associated with peripheral pathways.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Objective: &lt;/strong&gt;In this study we aimed to investigate the relationship between single nucleotide polymorphisms (SNPs) associated with the peripheral genes &lt;i&gt;CYP19A1&lt;/i&gt;, &lt;i&gt;CYP1A1&lt;/i&gt;, and &lt;i&gt;CYP1A2&lt;/i&gt; and the risk of LPE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Methods: &lt;/strong&gt;From August 2017 to August 2020, a total of 511 participants (139 LPE patients and 372 controls) were recruited. Trained medical professionals diagnosed LPE according to the standard definition set by the International Society for Sexual Medicine. Nine candidate SNPs were chosen and genotyped using the MassARRAY system. Allele and genotype frequencies of the SNPs among patients and controls were compared using the χ&lt;sup&gt;2&lt;/sup&gt; test. Logistic regression analysis, adjusted for age, was performed to calculate odds ratios (ORs) and 95% confidence intervals (CIs) using PLINK version 1.9. Haploview software was employed to analyze linkage disequilibrium and haplotype distribution. The interaction among candidate SNPs concerning LPE risk was evaluated using multifactor dimensionality reduction. The relationship between selected polymorphisms and specific features was assessed using analysis of variance.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Outcome: &lt;/strong&gt;Heterozygous SNPs located in the &lt;i&gt;CYP19A1&lt;/i&gt; (rs4646, rs17601876), &lt;i&gt;CYP1A1&lt;/i&gt; (rs1048943), and &lt;i&gt;CYP1A2&lt;/i&gt; (rs762551, rs2470890) genes showed significant correlations with the risk of LPE.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Results: &lt;/strong&gt;The findings of this study confirmed that heterozygous SNPs in the &lt;i&gt;CYP19A1&lt;/i&gt; (rs4646 AC vs CC: OR, 1.84; CI, 1.10-3.09; rs17601876 AG vs GG: OR, 1.80; CI, 1.06-3.05) and &lt;i&gt;CYP1A1&lt;/i&gt; genes (rs1048943 CT vs TT: OR, 1.71; CI, 1.02-2.87), respectively, can significantly increase the LPE risk. Participant scores for the Premature Ejaculation Diagnostic Tool (&lt;i&gt;P&lt;/i&gt; =.002) and International Index of Erectile Function-5 (&lt;i&gt;P&lt;/i&gt; =.020) differed significantly by genotype for the different genotypes of &lt;i&gt;CYP1A1&lt;/i&gt;-rs1048943. Haplotype analysis revealed strong linkage disequilibrium under &lt;i&gt;CYP1A2&lt;/i&gt;_rs762551-rs2470890 (D' = 1.00).&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Clinical implications: &lt;/strong&gt;The findings of this and other investigations of genetic determinants and potential pathogenic mechanisms of LPE may advance diagnostic and therapeutic opportunities in LPE patients.&lt;/p&gt;&lt;p&gt;&lt;strong&gt;Strengths and limitations: &lt;/strong&gt;In this study of LPE in men with CYP gene variants we addressed a current research gap. However, data on risk factors such as smoking and drinking were incomplete in both the case and control groups. In future studies we will expand the sample size and enhance data on risk factors for more precise assessment","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae056"},"PeriodicalIF":2.6,"publicationDate":"2024-09-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11411284/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294968","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Letter to the Editor on "Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study". 致编辑的信,主题为 "前列腺疾病、肾脏疾病、肾功能与勃起功能障碍风险之间的因果关系:一项双样本孟德尔随机研究"。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-15 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae058
Youqian Zhang, Li Li, Qiong Wen
{"title":"Letter to the Editor on \"Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study\".","authors":"Youqian Zhang, Li Li, Qiong Wen","doi":"10.1093/sexmed/qfae058","DOIUrl":"10.1093/sexmed/qfae058","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae058"},"PeriodicalIF":2.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403016/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Response to Letter to the Editor on "Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study". 对 "前列腺疾病、肾脏疾病、肾功能和勃起功能障碍风险之间的因果关系:一项双样本孟德尔随机研究 "致编辑的信的回复。
IF 2.6 3区 医学 Q1 MEDICINE, GENERAL & INTERNAL Pub Date : 2024-09-15 eCollection Date: 2024-08-01 DOI: 10.1093/sexmed/qfae059
Diliyaer Dilixiati, Kaisaierjiang Kadier, Jian-De Lu, Shiping Xie, Baihetiya Azhati, Reyihan Xilifu, Mulati Rexiati
{"title":"Response to Letter to the Editor on \"Causal associations between prostate diseases, renal diseases, renal function, and erectile dysfunction risk: a 2-sample Mendelian randomization study\".","authors":"Diliyaer Dilixiati, Kaisaierjiang Kadier, Jian-De Lu, Shiping Xie, Baihetiya Azhati, Reyihan Xilifu, Mulati Rexiati","doi":"10.1093/sexmed/qfae059","DOIUrl":"https://doi.org/10.1093/sexmed/qfae059","url":null,"abstract":"","PeriodicalId":21782,"journal":{"name":"Sexual Medicine","volume":"12 4","pages":"qfae059"},"PeriodicalIF":2.6,"publicationDate":"2024-09-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11403017/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142294970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
Sexual Medicine
全部 Acc. Chem. Res. ACS Applied Bio Materials ACS Appl. Electron. Mater. ACS Appl. Energy Mater. ACS Appl. Mater. Interfaces ACS Appl. Nano Mater. ACS Appl. Polym. Mater. ACS BIOMATER-SCI ENG ACS Catal. ACS Cent. Sci. ACS Chem. Biol. ACS Chemical Health & Safety ACS Chem. Neurosci. ACS Comb. Sci. ACS Earth Space Chem. ACS Energy Lett. ACS Infect. Dis. ACS Macro Lett. ACS Mater. Lett. ACS Med. Chem. Lett. ACS Nano ACS Omega ACS Photonics ACS Sens. ACS Sustainable Chem. Eng. ACS Synth. Biol. Anal. Chem. BIOCHEMISTRY-US Bioconjugate Chem. BIOMACROMOLECULES Chem. Res. Toxicol. Chem. Rev. Chem. Mater. CRYST GROWTH DES ENERG FUEL Environ. Sci. Technol. Environ. Sci. Technol. Lett. Eur. J. Inorg. Chem. IND ENG CHEM RES Inorg. Chem. J. Agric. Food. Chem. J. Chem. Eng. Data J. Chem. Educ. J. Chem. Inf. Model. J. Chem. Theory Comput. J. Med. Chem. J. Nat. Prod. J PROTEOME RES J. Am. Chem. Soc. LANGMUIR MACROMOLECULES Mol. Pharmaceutics Nano Lett. Org. Lett. ORG PROCESS RES DEV ORGANOMETALLICS J. Org. Chem. J. Phys. Chem. J. Phys. Chem. A J. Phys. Chem. B J. Phys. Chem. C J. Phys. Chem. Lett. Analyst Anal. Methods Biomater. Sci. Catal. Sci. Technol. Chem. Commun. Chem. Soc. Rev. CHEM EDUC RES PRACT CRYSTENGCOMM Dalton Trans. Energy Environ. Sci. ENVIRON SCI-NANO ENVIRON SCI-PROC IMP ENVIRON SCI-WAT RES Faraday Discuss. Food Funct. Green Chem. Inorg. Chem. Front. Integr. Biol. J. Anal. At. Spectrom. J. Mater. Chem. A J. Mater. Chem. B J. Mater. Chem. C Lab Chip Mater. Chem. Front. Mater. Horiz. MEDCHEMCOMM Metallomics Mol. Biosyst. Mol. Syst. Des. Eng. Nanoscale Nanoscale Horiz. Nat. Prod. Rep. New J. Chem. Org. Biomol. Chem. Org. Chem. Front. PHOTOCH PHOTOBIO SCI PCCP Polym. Chem.
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
0
微信
客服QQ
Book学术公众号 扫码关注我们
反馈
×
意见反馈
请填写您的意见或建议
请填写您的手机或邮箱
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
现在去查看 取消
×
提示
确定
Book学术官方微信
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术
文献互助 智能选刊 最新文献 互助须知 联系我们:info@booksci.cn
Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。
Copyright © 2023 Book学术 All rights reserved.
ghs 京公网安备 11010802042870号 京ICP备2023020795号-1