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A qualitative exploration of patient experiences living with autoimmune encephalitis. 自身免疫性脑炎患者生活经历的定性探讨。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40832-9
Robb Wesselingh, Nabil Seery, Katherine Ko, Christina Kazzi, Tiffany Rushen, Tracie Tan, Michelle Mykytowycz, Amanda Wells, Daria Muir, Tabitha Orth, Mastura Monif
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引用次数: 0
Association between modified cardiometabolic index and cardiometabolic multimorbidity in middle-aged and older adults: evidence from two nationwide cohort studies. 中老年人改良的心脏代谢指数与心脏代谢多病之间的关系:来自两项全国性队列研究的证据
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-41398-2
Shiqin Chen, Tian Lv, Jie Zhou
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引用次数: 0
Hydrogen sulfide rescues IFNγ/TNFα-induced intestinal epithelial barrier dysfunction by enhancing oxidative phosphorylation. 硫化氢通过增强氧化磷酸化修复IFNγ/ tnf α诱导的肠上皮屏障功能障碍。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40348-2
Janaíne Prata de Oliveira, Matthias van Sligtenhorst, Cansu Akkaya, Astrid Verbiest, Victoria Francelino Alves, Marie Wallays, Schalk van der Merwe, Marc Ferrante, Tim Vanuytsel, John L Wallace, Marcelo N Muscará, Soraia K P Costa, Alexandre Denadai-Souza
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引用次数: 0
ITGA8 suppresses proliferation and metastasis of lung adenocarcinoma through the inhibition of glycolysis. ITGA8通过抑制糖酵解抑制肺腺癌的增殖和转移。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40678-1
Shuai-Jun Chen, Xiao-Lin Cui, Qian Li, Ling-Yan Xiao, Shan-Shan Rao, Yu-Zhi Lu, Hong-Feng Zhang
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引用次数: 0
The Tantawy technique for modeling fractional KdV and mKdV positron-acoustic solitary waves in an electron-positron-ion plasma with regularized [Formula: see text] distribution. 用Tantawy技术模拟正电子-正电子-离子等离子体中正则分布的分数阶KdV和mKdV正电子-声孤波。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-38597-2
Samir A El-Tantawy, Muhammad Khalid, Aljawhara H Almuqrin, Rania A Alharbey, Ashwag A Alharby
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引用次数: 0
A hybrid empirical and semi analytical inversion approach for remote sensing estimation of SPM in Ebinur Lake China. 艾比湖SPM遥感估算的经验与半解析混合反演方法
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40250-x
Changjiang Liu, Xingbin Xu, Yingxiu Wu, Fei Zhang, Wenming Zhang, Mou Leong Tan, Ye Yuan

The suspended particulate matter (SPM) is a key parameter influencing the quality of aquatic habitats. SPM directly impacts the habitat of the "soft gold" (Artemia) in Ebinur Lake and is a major contributor to saline dust within its watershed. However, significant variations among inversion models present a challenge for SPM monitoring via remote sensing. Using Ebinur Lake as a case study, this study identify an optimal strategy for SPM monitoring. The findings are as follows: (1) Ebinur Lake water shows complete absorption at 695 nm. (2) ESTARFM achieved a Red-band spatiotemporal fusion R2 ≥0.79, leading to an SPM inversion R2 of 0.75. (3) Compared to the empirical model (R2 ≥ 0.72, RMSE ≤ 78.95 mg/L), the QAA (Quasi-Analytical Algorithm) demonstrated superior adaptability (R2 ≥ 0.74, RMSE ≤ 61.12 mg/L). (4) The red-band reflectance consistency among Landsat sensors reaches R2 ≥ 0.76, with a cross-platform correlation of R2= 0.73 between Landsat 8 and Sentinel 2. (5) The QAA_655(665) model is effective for Landsat 8 and Sentinel 2, whereas the EXPM (the exponential model) is more suitable for Landsat 5/7 and fusion images. This study primarily addresses the challenge of spatiotemporal inadaptability in the long-term SPM inversion process for Ebinur Lake. It can serve as a reference for water color parameter retrieval via remote sensing in globally similar environmental contexts.

悬浮颗粒物(SPM)是影响水生生境质量的关键参数。SPM直接影响了艾比努尔湖“软金”(Artemia)的栖息地,是其流域内盐尘的主要贡献者。然而,不同反演模型之间的显著差异给SPM遥感监测带来了挑战。本研究以艾比努尔湖为例,确定了SPM监测的最佳策略。结果表明:(1)艾比努尔湖水在695 nm处完全吸收。(2) ESTARFM实现了红波段时空融合R2≥0.79,SPM反演R2为0.75。(3)与经验模型(R2≥0.72,RMSE≤78.95 mg/L)相比,拟解析算法(QAA)具有更强的适应性(R2≥0.74,RMSE≤61.12 mg/L)。(4) Landsat传感器间红波段反射率一致性R2≥0.76,Landsat 8与Sentinel 2跨平台相关R2= 0.73。(5) QAA_655(665)模型适用于Landsat 8和Sentinel 2,而EXPM(指数模型)更适用于Landsat 5/7和融合图像。本研究主要解决了艾比湖SPM长期反演过程中存在的时空不适应性问题。为全球相似环境下的水色遥感参数检索提供参考。
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引用次数: 0
Sintered poultry-base waste as low-cost adsorbent for the uptake of Congo red: insight into kinetics, isotherms and thermodynamics. 烧结家禽基废物作为刚果红吸收的低成本吸附剂:洞察动力学,等温线和热力学。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40647-8
Salah Ud Din, Arogundade Ibrahim, Ali Shawabkeh, Khairia Mohammed Al-Ahmary, Nuha Y Elamin, Saedah R Al-Mhyawi, Hamad AlMohamadi, Mohammad Elamin, Jamelah S Al-Otaibi
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引用次数: 0
Epidemiology of refractive errors and its associated factors among medical students. 医学生屈光不正的流行病学及其相关因素
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40321-z
Alo Edin, Salah Mohammed, Ashenafi Abreha, Chalachew Muche, Elias Abera, Halima Ayalew Kebede, Asqual Gebreslassie Gebremariam, Angefa Ayele

Refractive error is the leading cause of correctable visual impairment and preventable blindness worldwide. It is a growing public health concern, particularly among the younger population, including medical students, who represent a vital future workforce for developing countries like Ethiopia. Poor ocular health can negatively impact academic performance, productivity, and overall quality of life, further contributing to the economic burden. Despite the increasing prevalence of REs globally, there is a lack of evidence regarding their prevalence and associated factors among medical students in Ethiopia. Therefore, this study was aimed to assess the prevalence and factors associated with refractive error among medical students. An institutional based cross sectional study design using simple random sampling technique was employed to select 422 undergraduate medical students at Hawassa University College of Medicine and Health Sciences after proportional allocation done for five batches. The study was conducted from September 2023 to October 2023. The data were collected using semi -structured questionnaires and clinical examination check list adapted from previous studies. The collected data were entered by kobo tool and exported and analyzed with Statistical Packages for the Social Science version 26.Variables with p-value < 0.05 in multivariable logistic regression were considered as statistically significant. A total of 417 participants with a response rate of 98.8% were involved in this study. Prevalence of refractive error was 10.3% (95%CI: 7.2%-13.4%). In multivariable logistic regression analysis, lack of outdoor activity [AOR = 2.382(95% CI (1.084-5.234)], no Active rest [AOR = 2.442(95% CI 1.064-5.608)] previous eye operation [AOR = 4.382 (95% CI (1.781-10.784)] and eye trauma (AOR: 7.188; 95%CI: 2.178-23.724)] were significantly associated with refractive error. The study underscores a remarkable prevalence of refractive errors among medical students, consistent with findings from comparable settings and populations. The significant links identified between refractive errors and modifiable lifestyle factors such as reduced outdoor activity, lack of active breaks, prior ocular surgeries, and eye trauma emphasize the influence of demanding academic schedules and limited environmental exposure on visual health. These insights call for proactive screening and the implementation of targeted preventive measures to mitigate refractive error risks. Addressing these factors is critical for preserving the ocular well-being and academic efficacy of medical students.

屈光不正是世界范围内可矫正视力损害和可预防失明的主要原因。这是一个日益令人关注的公共卫生问题,特别是在年轻人口中,包括医科学生,他们是埃塞俄比亚等发展中国家未来至关重要的劳动力。眼健康状况不佳会对学习成绩、生产力和整体生活质量产生负面影响,进一步造成经济负担。尽管REs在全球范围内的患病率不断上升,但缺乏关于其在埃塞俄比亚医学生中的患病率及其相关因素的证据。因此,本研究旨在评估医学生屈光不正的患病率及相关因素。采用基于机构的横断面研究设计,采用简单随机抽样技术,对阿瓦萨大学医学与健康科学学院的422名本科医学生进行5批比例分配。该研究于2023年9月至2023年10月进行。资料收集采用半结构化问卷调查和临床检查表改编自以往的研究。收集的数据通过kobo工具输入,并使用Statistical Packages for The Social Science version 26导出和分析。具有p值的变量
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引用次数: 0
How does agricultural product quality and safety regulation drive agricultural economic growth: a quasi-natural experiment from China's agricultural product quality and safety county pilot policy. 农产品质量安全监管如何带动农业经济增长:来自中国农产品质量安全县试点政策的准自然实验。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-40954-0
Lei Zhang, Hongli Zhang

The establishment of Agricultural Product Quality and Safety Counties not only enhances the quality and safety standards of agricultural products, effectively ensuring food safety and consumption security, but also holds significant implications for accelerating the transformation of agricultural development patterns and advancing modern agriculture. Based on panel data from 1,609 Chinese counties from 2010 to 2023, this study employs the national pilot policy for Agricultural Product Quality and Safety Counties as a quasi-natural experiment and utilizes a multi-period difference-in-differences approach to examine the impact of establishing these counties on agricultural economic growth and its underlying mechanisms. The findings reveal that: (1) the pilot policy significantly promotes county-level agricultural economic growth, a conclusion that remains robust after a series of robustness checks; (2) heterogeneity analysis indicates the policy's effects are more pronounced in central and eastern regions, major grain-producing areas, and regions with higher levels of economic development, digital infrastructure, and transportation facilities; (3) mechanism analysis demonstrates that the policy facilitates agricultural economic development by promoting expanded operational scale and the development of geographical indications. This study provides theoretical support and policy references for further expanding the Agricultural Product Quality and Safety County initiative and for government agencies to formulate development policies tailored to local conditions.

建立农产品质量安全县,不仅提高了农产品质量安全标准,有效保障了食品安全和消费安全,而且对加快转变农业发展方式、推进现代农业发展具有重要意义。本研究基于2010 - 2023年中国1609个县的面板数据,采用国家农产品质量安全县试点政策作为准自然实验,采用多期异中差方法,考察了建立农产品质量安全县对农业经济增长的影响及其机制。研究结果表明:(1)试点政策显著促进了县域农业经济增长,经过一系列稳健性检验,这一结论仍然是稳健的;(2)异质性分析表明,政策在中东部地区、粮食主产区以及经济发展水平、数字基础设施和交通设施较高的地区效果更为明显;(3)机制分析表明,政策通过促进经营规模的扩大和地理标志的开发,促进了农业经济的发展。本研究为进一步扩大“农产品质量安全县”建设规模,为政府部门制定因地制宜的发展政策提供理论支持和政策参考。
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引用次数: 0
Role of friction on the formation of confined granular structures. 摩擦对受限颗粒结构形成的作用。
IF 3.9 2区 综合性期刊 Q1 MULTIDISCIPLINARY SCIENCES Pub Date : 2026-02-23 DOI: 10.1038/s41598-026-39896-4
Vinícius P S Oliveira, Danilo S Borges, Erick M Franklin, Jorge Peixinho

Metastable fluidized granular systems can spontaneously defluidize, forming glass- or crystal-like structures. We performed experiments with polymer spheres of different friction and roughness fluidized in a vertical water pipe flow. Velocity fluctuations were higher for high friction materials. Monodisperse particles form a crystal-like shell on the cylinder wall for a range of flow rates and number of particles. For polytetrafluoroethylene (PTFE) spheres with a friction coefficient near 0.1, structural organization was assessed through nearest-neighbor angle analysis, featuring hexagonal packing with defects. At such low friction, defects decreased, while contact chains became longer and more aligned. These findings highlight the role of surface properties in the emergence of ordered or disordered structures, offering new insights into the mechanisms governing glass- and crystal-like arrangements in fluidized particle systems.

亚稳流化颗粒系统可以自发脱流化,形成玻璃或晶体状结构。我们对不同摩擦和粗糙度的聚合物球在垂直水管流动中进行了流化实验。高摩擦材料的速度波动较大。在一定的流速和颗粒数量范围内,单分散颗粒在圆筒壁上形成晶体状外壳。对于摩擦系数接近0.1的聚四氟乙烯(PTFE)球,通过最近邻角分析来评估结构组织,具有六边形填充和缺陷。在如此低的摩擦下,缺陷减少,而接触链变得更长,更整齐。这些发现强调了表面性质在有序或无序结构出现中的作用,为流化颗粒系统中控制玻璃和晶体状排列的机制提供了新的见解。
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引用次数: 0
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Scientific Reports
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