Abstract Background: Basal cell carcinoma (BCC) is a malignant tumor originating from non- keratinizing cells originating from the basal layer of the epidermis. Basal cell carcinoma is the most common malignant tumor, nearly 90% of all non-melanoma skin cancers. Clinically, BCC is difficult to distinguish, final diagnosis determined based on histopathological examination of complete tumor tissue. Based on histological growth patterns, BCC is divided into two, non- aggressive type (nodular and superficial) and aggressive type (infiltration, micronodular, fibroepithelial, basoskuamosa, keratotic, adnexal differentiation). The examination technique by analyzing the proteins or genes involved is related to the aggressiveness of basal cell carcinoma. Objective: This study was conducted to determine the comparison of expression of Bcl-2 in periocular basal type aggressive and non-aggressive carcinomas in dr. Mohammad Hoesin Palembang. Methodology: A cross sectional analytic study from 26 periocular basal cell carcinoma patients in RSUP dr. Mohammad Hoesin Palembang, January 2014- June 2018. Histopathologic features were examined with hematoxylin-eosine staining and imunohistochemical were examined with Bcl-2 monoclonal antibody. Data were analyzed by bivariate analysis, using chi-square test and fisher exact test. Results: Positive Bcl-2 expression was more common in periocular basal cell carcinoma (93.8%) than aggressive (50%), and nodular type (93.8%) compared to other types of histological differentiation. Positive Bcl-2 expression was also higher in female patients (90.9%) than males (66.7%). There is a significant relationship between expression of Bcl-2 and growth patterns, differentiation of cell histology and also sex of patients with basal cell carcinoma. Conclusion: In this study, there was a significant correlation between expression of Bcl-2 and aggressive and non-aggressive periocular basal cell carcinoma in RSUP dr. Mohammad Hoesin Palembang.
背景:基底细胞癌(Basal cell carcinoma, BCC)是一种起源于表皮基底层非角化细胞的恶性肿瘤。基底细胞癌是最常见的恶性肿瘤，占所有非黑色素瘤皮肤癌的近90%。临床上，BCC难以区分，最终诊断需依靠完整肿瘤组织的组织病理学检查。根据组织学生长模式，BCC分为两种，非侵袭型(结节性和浅表性)和侵袭型(浸润性、小结节性、纤维上皮性、basoskuamosa、角化性、附件分化)。通过分析相关蛋白或基因的检测技术与基底细胞癌的侵袭性有关。目的:本研究旨在比较Mohammad Hoesin Palembang医生眼周基底型侵袭性癌和非侵袭性癌中Bcl-2的表达。方法:2014年1月至2018年6月，Mohammad Hoesin Palembang博士在RSUP对26名眼周基底细胞癌患者进行了横断面分析研究。采用苏木精-伊红染色检测组织病理特征，Bcl-2单克隆抗体检测免疫组织化学。资料采用双变量分析，采用卡方检验和fisher精确检验。结果:Bcl-2阳性表达在眼周基底细胞癌中(93.8%)高于侵袭性(50%)，结节型(93.8%)高于其他组织学分化类型。女性患者Bcl-2阳性表达率(90.9%)高于男性(66.7%)。Bcl-2的表达与基底细胞癌患者的生长方式、细胞组织学分化及性别有显著关系。结论:在本研究中，Bcl-2的表达与RSUP dr. Mohammad Hoesin Palembang侵袭性和非侵袭性眼周基底细胞癌之间存在显著相关性。
{"title":"Comparison of BCL-2 Ecpression in Periocular Basal Cell Carcinoma Aggressive and Non-Aggressive Types in Mohammad Hoesin Hospital Palembang","authors":"Fera Yunita Rodhiaty, Ika Kartika, Ibrahim","doi":"10.37275/sjo.v1i2.40","DOIUrl":"https://doi.org/10.37275/sjo.v1i2.40","url":null,"abstract":"Abstract \u0000Background: Basal cell carcinoma (BCC) is a malignant tumor originating from non- keratinizing cells originating from the basal layer of the epidermis. Basal cell carcinoma is the most common malignant tumor, nearly 90% of all non-melanoma skin cancers. Clinically, BCC is difficult to distinguish, final diagnosis determined based on histopathological examination of complete tumor tissue. Based on histological growth patterns, BCC is divided into two, non- aggressive type (nodular and superficial) and aggressive type (infiltration, micronodular, fibroepithelial, basoskuamosa, keratotic, adnexal differentiation). The examination technique by analyzing the proteins or genes involved is related to the aggressiveness of basal cell carcinoma. \u0000Objective: This study was conducted to determine the comparison of expression of Bcl-2 in periocular basal type aggressive and non-aggressive carcinomas in dr. Mohammad Hoesin Palembang. \u0000Methodology: A cross sectional analytic study from 26 periocular basal cell carcinoma patients in RSUP dr. Mohammad Hoesin Palembang, January 2014- June 2018. Histopathologic features were examined with hematoxylin-eosine staining and imunohistochemical were examined with Bcl-2 monoclonal antibody. Data were analyzed by bivariate analysis, using chi-square test and fisher exact test. \u0000Results: Positive Bcl-2 expression was more common in periocular basal cell carcinoma (93.8%) than aggressive (50%), and nodular type (93.8%) compared to other types of histological differentiation. Positive Bcl-2 expression was also higher in female patients (90.9%) than males (66.7%). There is a significant relationship between expression of Bcl-2 and growth patterns, differentiation of cell histology and also sex of patients with basal cell carcinoma. \u0000Conclusion: In this study, there was a significant correlation between expression of Bcl-2 and aggressive and non-aggressive periocular basal cell carcinoma in RSUP dr. Mohammad Hoesin Palembang.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"27 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75733353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Fahcreza, E. Iskandar, R. Hidayat, Petty Purwanita, Anang Tribowo, R. Erna
Abstract Background: Chemical trauma to the cornea is an emergency condition of the eye that requires early diagnosis and good treatment. Alkaline have ability to saponify fatty acids in cells and cell membranes which can make penetration into the stroma and destroy proteoglycans and collagen in cells. Aloe vera (AV) contains several active substances that are reported to have anti-inflammatory, immunomodulatory, and wound healing effects. AV has been reported to accelerate the healing process of corneal epithelial defects by increasing fibroblast proliferation, collagen production and growth factor production. This study aims to determine the difference between the effect of aloe vera extract with a concentration of 10%, 20%, 40% and BSS on the healing of extensive corneal lesions in white wistar rats alkaline trauma models. Method: This study was an experimental study with a pre and posttest only with control group design in vivo approach to 30 Wistar white rats which were divided into 5 treatment groups for 3 days. Comparative analysis of effectiveness using the ANNOVA test or the Kruskal Wallis test and continued by the post hoc test. Results: Based on the one way ANOVA test there was a statistically significant difference in effectiveness between the five treatment groups on the percentage of corneal wound healing area and TGF-β expression with an assessment of p = 0,000 each. The administration of alloevera (AV) concentration of 20% had a significant difference in percentage of healing of corneal lesions and TGF-β expression compared with other treatment groups with p = 0,000 each. Large differences in the area of corneal lesions in the 40% AV group were -0.45 in the BBS group, 0.146 in the 10% AV group, 0.493 in the 20% AV group. The difference in the AV group 10% was 0.30 in the BBS group, -064 in the AV group 20%, and -0.14 in the AV group 40%. However, TGFβ expression in the normal control group that did not receive treatment was 54.94 (53.21-56-12). TGFβ levels in the BSS group were 10.44, the 10% aloe vera group was 25.43, 47.99 for the 20% aloe vera group and 37.95 for the 40% aloe vera group. Conclusion: There is a difference between the effect of aloe vera extract with concentrations of 10%, 20%, 40% and BSS on the extensive healing of corneal lesions in white wistar rats with alkaline chemical trauma models.
{"title":"The Effect of Aloe Vera Extract to Extensive Lesion and Expression of Transforming Growth Factor (TGF-β) on Alkaline Chemical Trauma Cornea Model","authors":"Fahcreza, E. Iskandar, R. Hidayat, Petty Purwanita, Anang Tribowo, R. Erna","doi":"10.37275/sjo.v1i2.36","DOIUrl":"https://doi.org/10.37275/sjo.v1i2.36","url":null,"abstract":"Abstract \u0000Background: Chemical trauma to the cornea is an emergency condition of the eye that requires early diagnosis and good treatment. Alkaline have ability to saponify fatty acids in cells and cell membranes which can make penetration into the stroma and destroy proteoglycans and collagen in cells. Aloe vera (AV) contains several active substances that are reported to have anti-inflammatory, immunomodulatory, and wound healing effects. AV has been reported to accelerate the healing process of corneal epithelial defects by increasing fibroblast proliferation, collagen production and growth factor production. This study aims to determine the difference between the effect of aloe vera extract with a concentration of 10%, 20%, 40% and BSS on the healing of extensive corneal lesions in white wistar rats alkaline trauma models. \u0000Method: This study was an experimental study with a pre and posttest only with control group design in vivo approach to 30 Wistar white rats which were divided into 5 treatment groups for 3 days. Comparative analysis of effectiveness using the ANNOVA test or the Kruskal Wallis test and continued by the post hoc test. \u0000Results: Based on the one way ANOVA test there was a statistically significant difference in effectiveness between the five treatment groups on the percentage of corneal wound healing area and TGF-β expression with an assessment of p = 0,000 each. The administration of alloevera (AV) concentration of 20% had a significant difference in percentage of healing of corneal lesions and TGF-β expression compared with other treatment groups with p = 0,000 each. Large differences in the area of corneal lesions in the 40% AV group were -0.45 in the BBS group, 0.146 in the 10% AV group, 0.493 in the 20% AV group. The difference in the AV group 10% was 0.30 in the BBS group, -064 in the AV group 20%, and -0.14 in the AV group 40%. However, TGFβ expression in the normal control group that did not receive treatment was 54.94 (53.21-56-12). TGFβ levels in the BSS group were 10.44, the 10% aloe vera group was 25.43, 47.99 for the 20% aloe vera group and 37.95 for the 40% aloe vera group. \u0000Conclusion: There is a difference between the effect of aloe vera extract with concentrations of 10%, 20%, 40% and BSS on the extensive healing of corneal lesions in white wistar rats with alkaline chemical trauma models.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90527710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
ABSTRACT Background: Retinoblastoma is a malignant tumor with an average incidence of one case per 15,000-20,000 births. Retinoblastoma is associated with the presence of the Rb1 gene mutation which has role in preventing DNA replication. Various studies have linked the existence of p16INK4A as a CDK inhibitor that inhibits Cyclin D and CDK4 so that the activity of the Rb1 gene is inhibited. Objective: This study was conducted to identify p16INK4A expression on Retinoblastoma at Mohammad Hoesin Hospital. Methodology: A descriptive study used on the paraffin blocks of 14 cases Retinoblastoma in Mohammad Hoesin Hospital Palembang from January 2014- July2018. Histopathologic feature were examined with Hematoxylin- Eosin staining and immunohistochemical were examined with p16INK4A antibody. Data were analyzed using SPSS version23 to identify histopathological feature of p16INK4A expression in Retinoblastoma Results: Most retinoblastoma samples in this study were expressed in p16INK4A (92.86%). The degree of differentiation of retinoblastoma with the largest number at Mohammad Hoesin Hospital is moderately differentiated (57.14%). Retinoblastoma invasion of the optic nerve and sclera in the study at Mohammad Hoesin Hospital, respectively at 57.14% and 42.86%. Conclusion: Most retinoblastoma samples in this study were expressed in p16INK4A.
背景:视网膜母细胞瘤是一种恶性肿瘤，平均发病率为1例/ 15000 - 20000例新生儿。视网膜母细胞瘤与Rb1基因突变的存在有关，Rb1基因突变在阻止DNA复制中起作用。各种研究已将p16INK4A的存在与CDK抑制剂联系起来，该抑制剂抑制Cyclin D和CDK4，从而抑制Rb1基因的活性。目的:研究p16INK4A在默罕默德·霍辛医院视网膜母细胞瘤组织中的表达。方法:对2014年1月至2018年7月在Palembang Mohammad Hoesin医院治疗的14例视网膜母细胞瘤的石蜡块进行描述性研究。采用苏木精-伊红染色检测组织病理特征，p16INK4A抗体检测免疫组化。采用SPSS version23对数据进行分析，确定p16INK4A在视网膜母细胞瘤中表达的组织病理学特征。结果:本研究中大多数视网膜母细胞瘤样本中表达p16INK4A(92.86%)。Mohammad Hoesin医院数量最多的视网膜母细胞瘤分化程度为中度分化(57.14%)。在Mohammad Hoesin医院的研究中，视网膜母细胞瘤侵袭视神经和巩膜的比例分别为57.14%和42.86%。结论:本研究中大多数视网膜母细胞瘤样本均表达p16INK4A。
{"title":"P16INK4A Expression on Retinoblastoma at Mohammad Hoesin Hospital Palembang","authors":"Sri Tanty Fuji A Harahap, Ika Kartika, Rusdianto","doi":"10.37275/sjo.v1i1.37","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.37","url":null,"abstract":"ABSTRACT \u0000Background: Retinoblastoma is a malignant tumor with an average incidence of one case per 15,000-20,000 births. Retinoblastoma is associated with the presence of the Rb1 gene mutation which has role in preventing DNA replication. Various studies have linked the existence of p16INK4A as a CDK inhibitor that inhibits Cyclin D and CDK4 so that the activity of the Rb1 gene is inhibited. \u0000Objective: This study was conducted to identify p16INK4A expression on Retinoblastoma at Mohammad Hoesin Hospital. \u0000Methodology: A descriptive study used on the paraffin blocks of 14 cases Retinoblastoma in Mohammad Hoesin Hospital Palembang from January 2014- July2018. Histopathologic feature were examined with Hematoxylin- Eosin staining and immunohistochemical were examined with p16INK4A antibody. Data were analyzed using SPSS version23 to identify histopathological feature of p16INK4A expression in Retinoblastoma \u0000Results: Most retinoblastoma samples in this study were expressed in p16INK4A (92.86%). The degree of differentiation of retinoblastoma with the largest number at Mohammad Hoesin Hospital is moderately differentiated (57.14%). Retinoblastoma invasion of the optic nerve and sclera in the study at Mohammad Hoesin Hospital, respectively at 57.14% and 42.86%. \u0000Conclusion: Most retinoblastoma samples in this study were expressed in p16INK4A.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78095571","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Abstract Background: Convergence Insufficiency (CI) is an inability to perform convergence movements when doing near activity. The prevalence of CI was estimated varying between 0.1%-8%. One of the easiest therapeutic attempts from some research have showed the effectiveness to overcome CI is by pencil push up therapy. This study is to determine the improvement of CI symptoms and signs in patients after performing the pencil push up exercise for 8 weeks. Methods: This clinical trial was conducted on October 2016-March 2017. Nineteen patients who met the inclusion criteria was obtained. The frequency and distribution of data is described in tabular form and the effectiveness of pencil push up therapy is analyzed with Paired T Test and Wilcoxon test. Result: Patients with CI had an average age of approximately 22 years, with the sex ratio of females and males being 3:2. After 8 weeks of pencil push up therapy, there was a significant decrease of Convergence Insufficiency Symptom Survey (CISS) value from 25.2±3.72 to 15.7±5.64 (p=0.000), significantly decreased Near Point Convergence (NPC) value from 13.7±1.88 cm to 9.05±2.99 cm (p=0.000), significantly decreased Red Blue Test (RBT) value from 14.2±1.84 to 9,36±3.22 cm (p=0.000), and significantly decreased Penlight Red/Green Test (PLT) from 16.7±2.69 to 10.7±4.13 cm (p=0.000). A number of Alternate Cover Test (ACT) positives also decreased from 4 to 2 samples but not significant (p=0,500). Symptoms and signs of CI were improved in 14 samples (73.7%). Conclusion: Pencil push up therapy for 8 weeks is effective to improve symptoms and signs of convergence insufficiency.
摘要背景:收敛不足(CI)是指在进行近距离活动时无法进行收敛运动。CI的患病率估计在0.1%-8%之间。一些研究表明，克服认知障碍的最简单的治疗方法之一是铅笔推举疗法。本研究旨在确定患者在进行铅笔俯卧撑运动8周后CI症状和体征的改善情况。方法:本临床试验于2016年10月- 2017年3月进行。19例患者符合纳入标准。数据的频率和分布以表格形式描述，用配对T检验和Wilcoxon检验分析铅笔俯卧撑疗法的有效性。结果:CI患者平均年龄约为22岁，男女性别比为3:2。铅笔推高治疗8周后，收敛功能不全症状调查(CISS)值从25.2±3.72降至15.7±5.64 (p=0.000)，近点收敛(NPC)值从13.7±1.88 cm降至9.05±2.99 cm (p=0.000)，红蓝测试(RBT)值从14.2±1.84降至9.36±3.22 cm (p=0.000)， Penlight红绿测试(PLT)值从16.7±2.69降至10.7±4.13 cm (p=0.000)。替代覆盖测试(ACT)阳性的数量也从4个样本减少到2个样本，但不显著(p=0,500)。14例(73.7%)CI症状和体征得到改善。结论:铅笔上推法治疗8周可有效改善收敛不足的症状和体征。
{"title":"Effectiveness of Eight Weeks Pencil Push Up Therapy for Patients with Convergence Insufficieny in Mohammad Hoesin Hospital Palembang","authors":"Andrian Suner, Linda Trisna","doi":"10.37275/sjo.v1i1.42","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.42","url":null,"abstract":"Abstract \u0000Background: Convergence Insufficiency (CI) is an inability to perform convergence movements when doing near activity. The prevalence of CI was estimated varying between 0.1%-8%. One of the easiest therapeutic attempts from some research have showed the effectiveness to overcome CI is by pencil push up therapy. This study is to determine the improvement of CI symptoms and signs in patients after performing the pencil push up exercise for 8 weeks. \u0000Methods: This clinical trial was conducted on October 2016-March 2017. Nineteen patients who met the inclusion criteria was obtained. The frequency and distribution of data is described in tabular form and the effectiveness of pencil push up therapy is analyzed with Paired T Test and Wilcoxon test. \u0000Result: Patients with CI had an average age of approximately 22 years, with the sex ratio of females and males being 3:2. After 8 weeks of pencil push up therapy, there was a significant decrease of Convergence Insufficiency Symptom Survey (CISS) value from 25.2±3.72 to 15.7±5.64 (p=0.000), significantly decreased Near Point Convergence (NPC) value from 13.7±1.88 cm to 9.05±2.99 cm (p=0.000), significantly decreased Red Blue Test (RBT) value from 14.2±1.84 to 9,36±3.22 cm (p=0.000), and significantly decreased Penlight Red/Green Test (PLT) from 16.7±2.69 to 10.7±4.13 cm (p=0.000). A number of Alternate Cover Test (ACT) positives also decreased from 4 to 2 samples but not significant (p=0,500). Symptoms and signs of CI were improved in 14 samples (73.7%). \u0000Conclusion: Pencil push up therapy for 8 weeks is effective to improve symptoms and signs of convergence insufficiency.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80823512","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Sharp vision is a major concern in cataract cases. Sharp improvement in vision is the expected outcome of the management of cataract cases, namely by operative measures. Before surgery, there are several ophthalmological examinations that must be performed. Quantitative instruments have been developed to determine the visual potential of eyes that experience turbidity of refractive media. One examination that can be done is a retinometry examination that is the examination of the sharp potential of vision with a retinometer. Retinometry is a process of measuring sharp eyes using a retinometer to determine the potential for sharp eyesight. Retinometer is one tool that uses the principle of interference fringes to assess the patient's sharp vision through a cloudy lens. On a retinometer, a light source is split into two rays which then enter the least turbid lens area so that interference grating is formed on the retina. The lattice can have a vertical, horizontal or oblique meridian orientation
{"title":"Retinometry : a Literature Review","authors":"Febrina Art, Ramzi Amin, Ak Ansyori","doi":"10.37275/sjo.v1i1.31","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.31","url":null,"abstract":"Sharp vision is a major concern in cataract cases. Sharp improvement in vision is the expected outcome of the management of cataract cases, namely by operative measures. Before surgery, there are several ophthalmological examinations that must be performed. Quantitative instruments have been developed to determine the visual potential of eyes that experience turbidity of refractive media. One examination that can be done is a retinometry examination that is the examination of the sharp potential of vision with a retinometer. \u0000Retinometry is a process of measuring sharp eyes using a retinometer to determine the potential for sharp eyesight. Retinometer is one tool that uses the principle of interference fringes to assess the patient's sharp vision through a cloudy lens. On a retinometer, a light source is split into two rays which then enter the least turbid lens area so that interference grating is formed on the retina. The lattice can have a vertical, horizontal or oblique meridian orientation","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"87 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90933399","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Introduction. The cause of blood vessels abnormalities in the retina in addition to diabetes is obstruction in the veins. In general, retinal vein blockages are distinguished in two types i.e. blockage of retinal veins (BRVO) and obstruction of the central vein of the retina (CRVO). Reported a case of a central retinal vein occlusion with intravitreal anti-injection treatment of a VEGF Bevacizumab. Case presentation. A man, Mr. T, aged 52 years, with an address outside the city, the work of the foreman, came to RSMH's eye on October 2014. Anamnesis the main complaint of the right eye eyesight was suddenly dark since, one day before. One day before go to hospital, the sufferer complained about the right eye suddenly until it felt dark. He also complain often headaches without nausea and vomiting since before his right eye vision becomes blurred. Intravitreal anti-VEGF injection in these patients is planned to be re-done 4-6 weeks after the first injection if there has been no improvement in his vision. Evaluation of the effectiveness of intravitreal Bevacizumab anti-VEGF therapy through sharp improvement of vision, clinical features and anatomical improvement. Conclusion. A case of central retinal vein occlusion was reported in a 52-year-old male. After anamnesis, ophthalmologic examination and investigations, a diagnosis of CRVO is managed by intravitreal Anti VEGF injection.
{"title":"Effect Anti VEGF Intravitreal to Central Retinal Vein Occlusion","authors":"Tiara Mayasari, Ramzi Amin, Ak Ansyori","doi":"10.37275/sjo.v1i1.8","DOIUrl":"https://doi.org/10.37275/sjo.v1i1.8","url":null,"abstract":"Introduction. The cause of blood vessels abnormalities in the retina in addition to diabetes is obstruction in the veins. In general, retinal vein blockages are distinguished in two types i.e. blockage of retinal veins (BRVO) and obstruction of the central vein of the retina (CRVO). Reported a case of a central retinal vein occlusion with intravitreal anti-injection treatment of a VEGF Bevacizumab. \u0000Case presentation. A man, Mr. T, aged 52 years, with an address outside the city, the work of the foreman, came to RSMH's eye on October 2014. Anamnesis the main complaint of the right eye eyesight was suddenly dark since, one day before. One day before go to hospital, the sufferer complained about the right eye suddenly until it felt dark. He also complain often headaches without nausea and vomiting since before his right eye vision becomes blurred. Intravitreal anti-VEGF injection in these patients is planned to be re-done 4-6 weeks after the first injection if there has been no improvement in his vision. Evaluation of the effectiveness of intravitreal Bevacizumab anti-VEGF therapy through sharp improvement of vision, clinical features and anatomical improvement. \u0000Conclusion. A case of central retinal vein occlusion was reported in a 52-year-old male. After anamnesis, ophthalmologic examination and investigations, a diagnosis of CRVO is managed by intravitreal Anti VEGF injection.","PeriodicalId":22012,"journal":{"name":"Sriwijaya Journal of Ophthalmology","volume":"81 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2018-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77116024","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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