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A Molecular Docking Study towards Finding Herbal Treatment against Polycystic OvarySyndrome (PCOS) 多囊卵巢综合征(PCOS)中药治疗的分子对接研究
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1006.0982s1219
Anshul Kamboj, Devvret Verma, D. Sharma, Kumud Pant, B. Pant, Vijay Kumar
Polycystic ovary syndrome (PCOS) is one of thewhich has affected reproductive-age women, it is characterizedby hyperinsulinemia, hyperandrogenism, menstrualirregularities, and long-term metabolic disturbances. CYP 17(P450c 17α) is an enzyme that plays an essential role in thebiosynthesis of adrenal and gonadal steroids. Due tooverexpression of the CYP17 encoding gene androgen isconverted more efficiently to testosterone causinghyperandrogenism. By inhibiting this enzyme activity androgensynthesis can be prevented in the ovary. In this study, virtualscreening of the phytochemicals of fruit from plant Terminaliachebula, Terminaliabellirica and Emblica officinalis were usedas a ligand to identify a potent inhibitor of CYP17 enzyme. Thebinding affinity of phytochemicals with the target protein CYP17with the aid of AutoDockVina were explored. Metformin,spironolactone and clomiphene were used as control and bindingenergy of phytochemicals was compared with the docking scoreof control. All the phytocompounds shows inhibition of theCYP17 enzyme with a docking score of -3.7 to -9.5. Chebulanin,corilagin, neochebulinic acid, ellagic acid, chebulinic acid,1,6-diO-galloyl-d-glucose, 3,4,6-tri-O-glloyl-d-glucose, terchebulin,terflavin A, maslinic acid, arjunin, Isoquercitrin, rutin andchebulagic acid shows properties of potent inhibitor. This studyreveals that the phytochemicals of fruit from plant Terminaliachebula, T.bellirica and Emblica officinalis can be used as apotential de novo drug to treat infertility in PCOS.
多囊卵巢综合征(PCOS)是影响育龄妇女的疾病之一,其特点是高胰岛素血症、高雄激素症、月经不规则和长期代谢紊乱。cyp17 (P450c 17α)是一种在肾上腺激素和性腺激素的生物合成中起重要作用的酶。由于CYP17编码基因的过度表达,雄激素更有效地转化为睾酮,导致高雄激素症。通过抑制这种酶的活性,可以防止卵巢中的雄激素合成。在本研究中,通过对黄芪、黄芪和榆木果实中植物化学物质的虚拟筛选,鉴定了一种有效的CYP17酶抑制剂。利用AutoDockVina分析了植物化学物质与靶蛋白cyp17的结合亲和力。以二甲双胍、螺内酯和克罗米芬为对照,比较植物化学物质的结合能与对照的对接得分。所有植物化合物均表现出对cyp17酶的抑制作用,对接评分为-3.7 ~ -9.5。Chebulanin、corilagins、新checheulins酸、鞣花酸、chebullinacid、1,6-二没食子酰葡萄糖、3,4,6-三- o - gl酰葡萄糖、terflavin A、马山酸、arjunin、异槲皮苷、芦丁和chebulagacid表现出强效抑制剂的性质。本研究表明,黄芪、黄芪和黄刺果的化学成分可作为治疗多囊卵巢综合征不孕症的潜在药物。
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引用次数: 1
Designing of Autonomous Wheelchair for Movement in Standing Position 自主站立运动轮椅的设计
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1009.0982s1219
J. Kalra, Rajesh Pant, P. Negi, Vijay Kumar
Driving a manual wheelchair on any surface is adifficult task and past invented automatic wheelchairs areavailable at a very high cost in the market. The purpose of thispaper, work is to propose an autonomous wheelchair that willreduce human effort while moving on a surface with inclinationor declination and is available at a comparatively lower cost. Oneof the basic problems of user on manual wheelchair is toovercome barriers like kerb, rough surfaces, inaccessiblesurfaces etc. Though many research have been done in this field,but the question of overcoming these barriers always remains asa topic of discussion for many researchers. In our paper a motoroperated & electronically hand controlled autonomouswheelchair concept which can overcome the architecturalbarriers to a considerable extent has been developed. This paperinvolves the design of an ergonomically designed battery poweredwheelchair for multipurpose use. All the design parameters ofwheelchair's are based on the standard design of stair in India.Major part of the paper focuses on the proposed design conceptand mechanism and concludes by focusing upon the physicalworking model developed for the proposed design solution.
在任何地面上驾驶手动轮椅都是一项艰巨的任务,而过去发明的自动轮椅在市场上的价格非常高。本文的目的是提出一种自动轮椅,它可以减少人类在倾斜或倾斜的表面上移动时的努力,并且成本相对较低。手动轮椅使用者面临的基本问题之一是克服路缘、粗糙表面、难以进入的表面等障碍。虽然在这一领域已经做了很多研究,但如何克服这些障碍仍然是许多研究者讨论的话题。在我们的论文中,一个电动和电子手控制的自主轮椅的概念,可以克服很大程度上的结构障碍已经发展。本文设计了一种符合人体工程学的多用途电动轮椅。轮椅的所有设计参数均参照印度楼梯的标准设计。论文的主要部分侧重于提出的设计概念和机制,并通过关注为提出的设计解决方案开发的物理工作模型来结束。
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引用次数: 0
Does Education Affect the Online Impulse Buying in Millennials? 教育是否影响千禧一代的网上冲动购买?
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1019.0982s1219
Ambica Prakash Mani, V. M. Tripathi
The popularity and acceptance of online medium forbuying and selling has increased both in terms of popularacceptance and widespread reach in every nook and corner of thecountry. A similar rise has been observed in the tendency ofonline impulsive buying behaviour too. Impulsive or impulsebuying is unplanned and often done in a fraction of second oversome human stimulus that is usually uncontrollable. There is nodoubt to the fact that the exposure and inclination towards onlinemedium as a buying platform has increased significantly over thelast few years amongst all and its rise is particularly noteworthyin the generation Y. Today this young and well educated groupqualifies to be an important segment for marketers. This researchpaper explores the impact of education over online impulsivebuying behaviour in millennials of today.
网上买卖媒介的普及程度和接受程度在普及程度和广泛程度上都有所提高,遍及全国各个角落。网上的冲动购买行为也出现了类似的上升趋势。冲动或冲动购买是计划外的,通常是在几秒钟内完成的,而这些刺激通常是不可控的。毫无疑问,在过去的几年里,在线媒体作为一个购买平台的曝光率和倾向显著增加,尤其是在y一代中,这一增长尤其值得注意。今天,这一受过良好教育的年轻群体有资格成为营销人员的重要细分市场。这篇研究论文探讨了教育对当今千禧一代在线冲动购买行为的影响。
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引用次数: 0
E-Waste Generation and Management Practices in Dehradun, India 印度德拉敦的电子废物产生和管理实践
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1002.0982s1219
Anupriya Sharma Ghai, Kapil Ghai, D. Kapil, N. Sharma
The advancement in the electrical and electronicequipment and change in technology increases the demand ofelectronics appliances in the developing countries. Peoplepurchase electronic goods due to new features and capabilities. Alot more people sold or discard the older equipment’s without theknowledge of useful life which leads to enormous used electronicequipment called electronic waste (E-waste). In the developingcountries like India which ranked fifth in producing e-wasteglobally, due to the lack of enough infrastructure and impropermanagement practice. The present study evaluates theknowledge, management, dispose practices of e-waste andhazardous substances generated by the citizens of Dehradun,India in year 2019. An online questionnaire on 300 respondentsbased on calculating the sample size requirement was done inmid of year 2019.The outcome of the study show case the effectof e-waste generated by different income base groups with theinventory used by citizens in one year. Total number of heavymetals and plastics generated by household appliances and ICTand consumer electronics were also measured. The result showedup the need of awareness and urgent requirement of the seriousissues of E-waste. The state government must involve withoutwaiting for the upcoming adverse effects on environment andhealth risks to human lives.
电子电气设备的进步和技术的变化增加了发展中国家对电子电器的需求。人们购买电子产品是因为新的特性和功能。越来越多的人在不知道使用寿命的情况下出售或丢弃旧设备,导致大量的二手电子设备被称为电子废物(E-waste)。在像印度这样的发展中国家,由于缺乏足够的基础设施和管理不善,印度在全球产生电子废物方面排名第五。本研究评估了2019年印度德拉敦市民产生的电子废物和有害物质的知识、管理和处置做法。根据样本量要求,于2019年年中对300名受访者进行了在线问卷调查。研究结果显示了不同收入基础群体产生的电子垃圾与公民在一年内使用的库存的影响。还测量了家用电器和信息通信技术和消费电子产品产生的重金属和塑料的总数。结果表明,人们需要认识到电子垃圾问题的严重性,并提出了迫切的要求。州政府必须介入,而不是等待即将到来的对环境的不利影响和对人类生命的健康风险。
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引用次数: 0
Fin Efficiency Design of Micro-Channel for Nd: YAG Slab Laser Nd: YAG平板激光器微通道翅片效率设计
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1012.0982s1219
R. Pant, J. Kalra, Jagdish Singh Mehta, P. Negi
The heat generated by a Slab Lasers can exceed1,000 watts but the area available for cooling is too small. Thisresults in localization of heat flux which makes heat dissipation achallenge in slab lasers. The Heat transfer coefficient canincrease up to a very high range, which can’t be efficientlyachieved by the conventional water cooling. Micro-channelcoolers address this problem competently. These channelscontain liquid, which transfers heat to the sink with highefficiency.The objective of this paper is to design the microchannel coolers that will be efficiently capable of removing theheat from the slab laser without causing any thermal distortion inthe laser. The dimension of the slab is given as follows:-Length(l)=50mm, Width(w) =8mm and thickness(t)=2mm.
平板激光器产生的热量可以超过1000瓦,但可用于冷却的面积太小。这导致了热流的局部化,从而给平板激光器的散热带来了挑战。传热系数可以提高到一个非常高的范围,这是传统水冷却无法有效实现的。微通道冷却器很好地解决了这个问题。这些通道中含有液体,可以高效地将热量传递到水槽中。本文的目的是设计微通道冷却器,该冷却器将能够有效地从平板激光器中去除热量,而不会在激光器中引起任何热畸变。板坯的尺寸如下:-长(l)=50mm,宽(w) =8mm,厚(t)=2mm。
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引用次数: 0
Diaspora and Culture: A Study of Indian Immigration and Integumentary Anxiety in JhumpaLahiri’s The Namesake 散居与文化:朱姆帕拉希里《同姓》中印度移民与土著焦虑研究
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1016.0982s1219
Sulekha Varma, Raina Singh
This research aims at capturing the sense ofidentity, loneliness and untold anxiety among the immigrantsfrom the writing of one of the prominent authors writing inEnglish from Indian subcontinent. The Namesake, a well-knitnovel by the author Jhumpa Lahiri. The novel “The Namesake”depicts it the best kind of reference to classify Diaspora as theword ‘Diaspora’ as well as its prime role in this present era, thefirst and second generation who are struggling for identity,loneliness and the most prominent one is integumentry anxietyamong them. It is that untold anxiety which the people can’tdisclose to anyone. It remains in the very heart of them untoldand unexpressed. In fact Jhumpa Lahiri the novelist is child ofIndian immigrates and she is also migrated from her birthplaceEngland to America. The effect of both made her Diaspora writerand a migrant one. She mirrored the life of the Indian Diaspora,who are struggling for identity and the integumentary anxiety.They construct unhomely home in the foreign land.
本研究旨在通过一位来自印度次大陆的著名英语作家的写作来捕捉移民的认同感、孤独感和难以言表的焦虑感。同名小说,作者Jhumpa Lahiri写得很好。小说《同名同姓》将其描述为将散居侨民分类为“散居”一词的最佳参考,以及它在当今时代的主要作用,第一代和第二代正在为身份,孤独而挣扎,其中最突出的是integentry焦虑。这是人们无法向任何人透露的焦虑。它仍然在他们的内心深处,没有说出来,也没有表达出来。事实上,小说家Jhumpa Lahiri是印度移民的孩子,她也从她的出生地英国移民到美国。这两者的影响使她成为散居作家和移民作家。她反映了印度侨民的生活,他们正在为身份和外在的焦虑而挣扎。他们在异国他乡建造了不寻常的家园。
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引用次数: 0
A Profound Study of Women’s Pathetic Condition in Indian Society, the Selected Novels of Mulk RajAnand 对印度社会女性悲惨境遇的深刻研究——穆尔克·拉贾南德小说选集
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1017.0982s1219
The subordinates are always suppressed, they can beknown in terms of caste, class, gender, age. The current paperhas attempted to analyze and uncover the most suppressed genderhas been of the society in the selectednovels of Mulk Raj Anand.It would be an exploration of the concept or perception especiallythe women characters. The novel are Untouchable (1936), Coolie(1937) and The Road (1961).In these novels, he, indisputably,has established the reality of depreciating the women is the workof primordialpower of the apostolic people, who have finalizedthe future of them.
下属总是受到压制,他们可以根据种姓、阶级、性别、年龄来区分。本文试图分析和揭示穆尔克·拉吉·阿南德小说选集中最受压抑的社会性别。这将是对概念或感知的探索,尤其是女性角色。小说有《贱民》(1936)、《苦力》(1937)和《路》(1961)。在这些小说中,他毫无疑问地确立了贬低妇女的现实是使徒人民原始力量的产物,他们决定了妇女的未来。
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引用次数: 0
HBASE Data Security with AES Algorithm 使用AES算法的HBASE数据安全
Pub Date : 2020-07-01 DOI: 10.35940/ijrte.b1005.0982s1219
Chetan Pandey, Amit Juyal, Neeraj Panwar, Aditya Joshi
Since last decade almost every organization isfocusing more on collecting their data (big data) and makinganalysis of it also applying the concluded valuable outcomes overtheir organization. The use of smartphones and smart gadgetsfasten the gathering of data and enhances the three basic Vs(Volume/ Velocity/ Variety) of big data. This paper focuses on bigdata security but without fourth V i.e. Value within data, there isno need of securing big data. Perhaps this may be the reason whyHadoop have no security mechanism within its architecture sinceinitially the focus of big data is on the basis of three basic Vsonly. With this paper, here authors’ try to provide security to bigdata by using AES algorithm over HBase database. Authors justgiving an idea of big data security methodology and for that themain focus of data security is only on valuable contents of thedatabase.
自过去十年以来,几乎每个组织都更加关注收集数据(大数据)并对其进行分析,并将总结的有价值的结果应用于他们的组织。智能手机和智能设备的使用加快了数据的收集,增强了大数据的三个基本v (Volume/ Velocity/ Variety)。本文关注的是大数据安全,但如果没有第四个V,即数据内的价值,就不需要保护大数据。也许这就是为什么hadoop在其架构中没有安全机制的原因,因为最初大数据的重点是基于三个基本的Vsonly。在本文中,作者尝试在HBase数据库上使用AES算法为大数据提供安全性。作者只是给出了大数据安全方法的一个概念,因此数据安全的主要焦点只放在数据库的有价值的内容上。
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引用次数: 1
Web Revisitation using Content and Context Tokens 使用内容和上下文令牌的Web重访
Pub Date : 2020-05-30 DOI: 10.35940/ijrte.a2685.059120
Right now, the Internet is the most common medium people use to obtain access to knowledge. One's requirements vary from a single word sense to specialized papers and self-education. Revisiting previously visited web pages is one of the most common and unpleasant activities a person does. In fact, a significant primary feedback technique is included in tailoring the individual's memory of vigor and re-examination patterns. Our successful control of environment and object recollections, including decay and reinforcing techniques, may imitate device retention and retention mechanisms. This proposed solution takes into consideration the normal human retrieval method of utilizing episodic and textual memory signals for fast retrieval and includes a different site revisitation mechanism known as the "Web Page Preview" via meaning and information gained through user discovery and web page visits. The underlying methods for the collection, preservation, degradation and usage of meaning and quality of consumer memories for page re-discovery are addressed. Our 3 month user study says that of the time, location, and activity context factors in Web Page Prep, activity is the best recall guide, and context + content based re-discovery provides the highest results relative to context and content individual rediscovery. This concept, if completed, can be used to improve web surfing functionality by providing users a variety of apps with a rather simple UI.
现在,互联网是人们获取知识最常用的媒介。一个人的要求从单一的词义到专业论文和自我教育各不相同。重新访问以前访问过的网页是人们最常见和最不愉快的活动之一。事实上,一个重要的初级反馈技术包含在调整个体对活力和重新检查模式的记忆中。我们对环境和对象回忆的成功控制,包括衰减和强化技术,可能模仿了设备保留和保留机制。该解决方案考虑了正常的人类检索方法,即利用情景和文本记忆信号进行快速检索,并包括一种不同的网站重访机制,即“网页预览”,通过用户发现和网页访问获得的意义和信息。本文讨论了收集、保存、退化和使用消费者记忆的意义和质量以进行页面重新发现的基本方法。我们为期3个月的用户研究表明,在网页准备的时间、地点和活动背景因素中,活动是最好的回忆指南,而基于上下文+内容的重新发现提供了相对于上下文和内容个人重新发现的最高结果。这个概念,如果完成,可以通过为用户提供各种应用程序与一个相当简单的UI来改善网页浏览功能。
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引用次数: 0
An IoT based Ambulance Guidance System Under Emergency Condition 紧急情况下基于物联网的救护车引导系统
Pub Date : 2020-05-30 DOI: 10.35940/ijrte.f9005.059120
In our country almost all the states are facing traffic congestion severely, mainly in urban areas. The road accidents are increasing because of the traffic blockage which ruin the human lives. Due to population increase, the numbers of the regions are widening and the number of vehicles is also rising. Traffic is the main factor contributing to accident and it also causes some delay in getting to the destination. Thus traffic managing and regulating is the main traffic management problem. The ambulance and the traffic signals are integrated with some embedded systems to find out the accident spot through GPS. The accidents are determined by fixing the sensors in it. This paper provides an idea in order to control the accidents by implementing a solution where Traffic signals are dynamically operated in its way and traffic congestion rates are lowered
在我国,几乎所有的州都面临着严重的交通拥堵,主要集中在城市地区。由于交通堵塞,道路交通事故越来越多,严重危害了人们的生命安全。由于人口的增加,区域的数量在扩大,车辆的数量也在增加。交通是造成事故的主要因素,它也会导致到达目的地的一些延误。因此,交通管理和调节是交通管理的主要问题。救护车和交通信号与一些嵌入式系统相结合,通过GPS找到事故现场。事故是通过安装传感器来确定的。本文提出了一种交通信号按其方式动态运行,降低交通拥堵率的解决方案,为控制交通事故提供思路
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引用次数: 1
期刊
International Journal of Recent Technology and Engineering
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