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EVALUATION OF THE PROGNOSTIC SIGNIFICANCE OF SOME BIOLOGICAL FACTORS IN LOCAL AND GENERALIZED CLEAR CELL RENAL CANCER 局部及全身性透明细胞肾癌生物学因素对预后的影响
Pub Date : 2020-03-07 DOI: 10.37748/2687-0533-2020-1-1-1
A. N. Shevchenko, A. A. Breus, I. Neskubina, E. Dzhenkova, E. Filatova, D. A. Shvyrev
Purpose of the study. To evaluate the prognostic significance of biological factors VEGF-A, sVEGF-R1, VEGF-D, FGF, EGF, EGFR, IGF-1, IGF-2, IGFBP-1, IGFBP-2, somatotropin-releasing factor (GHRH) in kidney tissues (tumour tissue, tissue of the perifocal zone and conditionally intact tissue) in local and generalized clear cell renal cancer using ROC analysis.Materials and methods. Two groups of patients were included in the study. Group 1 comprised 50 patients with local kidney cancer (T1–3N0M0), while group 2 comprised 50 patients with metastatic kidney cancer (T1–4N0M1). 10% cytosolic fractions of the kidney tumour tissue were examined. The content of growth factors — somatotropinreleasing factor (GHRH), somatotropin-releasing factor (GHRH) — was determined by the ELISA assay using standard test systems. An assessment of prognostically unfavourable factors that significantly affect the generalization of the tumour process was carried out using binary logistic regression and ROC analysis.Results. The performed ROC analysis revealed diagnostically significant progression biomarkers and their critical values for clear cell renal cancer (for conditionally intact tissue, these values were: VEGF-A ≤ 9107.9 pg/g of tissue; VEGF-R1 ≤ 122.8 ng/g of tissue; FGF ≤ 364.7 pg/g of tissue; IGF-2 ≤ 148 ng/g of tissue; for perifocal tissue, VEGF-A ≤ 5839.6 pg/g of tissue; for tumour tissue, VEGF-A > 9622.5 pg/g of tissue, FGF ≤ 435.1 pg/g of tissue, somatotropin-releasing factor (GHRH) ≤ 158.6 ng/g of tissue). The obtained data contribute to optimization of the disease prognosis.Conclusion. It is established that the most prognostically significant markers of clear cell renal cancer progression include VEGF-A, FGF, somatotropin-releasing factor (GHRH), which can serve as an additional criterion for the differential diagnosis of progression and monitoring of clear cell renal cancer.   
研究目的:采用ROC分析评价肾组织(肿瘤组织、局灶周围组织和条件完整组织)中生物因子VEGF-A、sVEGF-R1、VEGF-D、FGF、EGF、EGFR、IGF-1、IGF-2、IGFBP-1、IGFBP-2、生长激素释放因子(GHRH)在局部和广泛性透明细胞肾癌中的预后意义。材料和方法。两组患者被纳入研究。1组50例局部肾癌(T1-3N0M0), 2组50例转移性肾癌(T1-4N0M1)。取肾肿瘤组织10%细胞质部分进行检测。生长激素释放因子(GHRH)、生长激素释放因子(GHRH)的含量采用ELISA法测定,采用标准检测系统。使用二元逻辑回归和ROC分析对显著影响肿瘤进程普遍化的预后不利因素进行评估。进行的ROC分析显示,透明细胞肾癌的进展生物标志物及其临界值(对于条件完整的组织,这些值为:VEGF-A≤9107.9 pg/g的组织;VEGF-R1≤122.8 ng/g组织;FGF≤364.7 pg/g组织;IGF-2≤148 ng/g组织;对于焦周组织,VEGF-A≤5839.6 pg/g;肿瘤组织VEGF-A > 9622.5 pg/g, FGF≤435.1 pg/g,生长激素释放因子(GHRH)≤158.6 ng/g。所得数据有助于优化疾病预后。目前已经确定,透明细胞肾癌进展最具预后意义的标志物包括VEGF-A、FGF、生长激素释放因子(GHRH),它们可以作为透明细胞肾癌进展鉴别诊断和监测的附加标准。
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引用次数: 2
ADOPTIVE CELL THERAPY: CURRENT ADVANCES 过继细胞疗法:最新进展
Pub Date : 2020-03-07 DOI: 10.37748/2687-0533-2020-1-1-4
Tatyana V. Shamova, Anastasiya O. Sitkovskaya, L. Vashchenko, E. Kechedzhieva
The immune system plays an important role in the development and treatment of many cancer types. This fact determined the emergence of numerous immunotherapeutic approaches, including that of adoptive cell therapy (ACT). In this article, we set out to describe the basic methods of adoptive cell cancer therapy, their application and development prospects. The first part of the article deals with the significance of immunotherapeutic methods for cancer treatment and describes the current state of the problem. The main part of the article provides information on the mechanisms of adoptive T cell (unmodified and genetically modified) transfer, the creation of dendritic cell vaccines and cytokine-induced killers (CIK). In addition, a review of recent achievements in the introduction of the aforementioned methods into the clinical practice is carried out. The conclusion is made that adoptive cell therapy can be considered as one of the most promising methods of cancer immunotherapy, which should be optimized for more effective use in the treatment of cancer.
免疫系统在许多癌症的发展和治疗中起着重要的作用。这一事实决定了许多免疫治疗方法的出现,包括过继细胞治疗(ACT)。本文就过继细胞癌治疗的基本方法、应用及发展前景作一综述。文章的第一部分讨论了免疫治疗方法对癌症治疗的意义,并描述了该问题的现状。文章的主要部分提供了关于过继性T细胞(未修饰和基因修饰)转移、树突状细胞疫苗和细胞因子诱导杀手(CIK)的创建机制的信息。此外,回顾了最近在将上述方法引入临床实践方面取得的成就。结果表明,过继细胞治疗是一种很有前途的肿瘤免疫治疗方法,应对其进行优化,使其更有效地应用于肿瘤的治疗。
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引用次数: 6
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South Russian Journal of Cancer
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