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The Little God of England: The Divine Right of James I and the English Response 英格兰的小上帝:詹姆斯一世的神权与英国的回应
Pub Date : 2022-05-01 DOI: 10.25172/jour.7.2.3
Nathan Greenhaw
This paper analyzes the development of James I’s theory of divine right in England and how its application elevated the sovereignty of the monarch to the extent of absolutism in the early seventeenth century. Since divine right ultimately conflicted with the ancient laws and customs of the English government, James’s theory provoked newfound interpretations of the political and judicial authority of the ruler. From a plethora of political treatises, religious sermons, and parliamentary records, these interpretations ultimately affected how governmental institutions, such as Parliament and the courts, interacted with the monarchy. Parliamentarians became more submissive to the king's will, the importance of constitutional law was diminished, and political theories grew more in favor of divine right. As such, by the end of James’s reign, divine right was no longer a theory but rather a political reality, a development which enabled the king to rule with absolute power, all at the expense of parliamentary autonomy, constitutional supremacy, and individual liberty. Therefore, discourse over the true nature of monarchal government not only became more prevalent, but divine right itself became significantly entrenched within the English monarchy. This development altered the English political landscape entirely, inevitably leading the kingdom to civil war in the 1640s and a fervent resurgence of divine right with the restoration of Charles II in 1660. Thus, this paper reveals that divine right during the reign of James I was paramount towards the transformation of the monarchy in early modern England, for it created a myriad of unique and complex understandings of rulership that would ultimately lead to the expansion of absolutism, civil conflict, and political unrest for the remainder of the century.
本文分析了詹姆斯一世神权理论在17世纪早期英国的发展,以及神权理论的运用如何将君主的主权提升到专制主义的程度。由于神权最终与英国政府的古代法律和习俗相冲突,詹姆斯的理论引发了对统治者政治和司法权威的新解释。从大量的政治论文、宗教布道和议会记录中,这些解释最终影响了议会和法院等政府机构与君主制的互动方式。国会议员越来越服从国王的意愿,宪法的重要性被削弱,政治理论越来越倾向于神权。因此,在詹姆斯统治末期,神权不再是一种理论,而是一种政治现实,这种发展使国王能够以绝对权力统治,不惜牺牲议会自治,宪法至上和个人自由。因此,关于君主政体本质的讨论不仅变得更加普遍,而且神权本身也在英国君主制中变得根深蒂固。这一发展完全改变了英国的政治格局,不可避免地导致了1640年代的内战,1660年查理二世复辟后,神权的狂热复苏。因此,本文揭示了詹姆斯一世统治时期的神权对近代早期英国君主制的转变至关重要,因为它创造了无数独特而复杂的统治理解,最终导致了专制主义的扩张,国内冲突,以及本世纪剩余时间的政治动荡。
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引用次数: 0
Volume 7, Issue 1 Digital Front Matter 第七卷,第1期数字前沿问题
Pub Date : 2022-01-01 DOI: 10.25172/jour.7.1.3
Hannah Web
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引用次数: 0
The Use of Ruthenium Complexes as Molecular Probes for Non-Canonical DNA 钌配合物作为非典型DNA分子探针的应用
Pub Date : 2022-01-01 DOI: 10.25172/7.1.2
Eleni Sullivan
This study considered the preparation of a new DNA binding Ruthenium polypyridyl complex possessing an infrared active nitrile group. The binding abilities of a novel Ruthenium complex, [Ru(TMP)2DPPZ-10-CN], to various forms of DNA—both canonical and non-canonical—were examined by performing multiple DNA titrations. DNA is of great interest as it is the carrier of genetic information for all living things. Damage to DNA can have drastically detrimental effects, so the study of its structure and replication is of great importance. Two non-canonical structures that are important are the G-quadruplex and i-motif which form at the telomeric and regulatory regions of genes, respectively, and have the ability to block telomerase activity and influence transcription. The complex was synthesized by microwave irradiation and purified using a silica column and an ion exchange with Amberlite 402. Six titrations were, then, performed with salmon sperm dsDNA, guanine monophosphate (GMP), G4T4G4, human telomere G-quadruplex, i-motif C5T3, and i-motif C30. The complex was found to favor non-canonical structures, particularly the G-quadruplex structure, because of its high [bp]/[Ru] concentrations. The higher concentration of base pairs or structures per Ruthenium molecule indicated that the complex had a high binding affinity for that particular DNA structure. These results support the notion that Ruthenium metal complexes can be used for theragnostic purposes and can be used to target the telomeric region of genes where G-quadruplex structures can be found and influence transcription initiation and inhibit telomerase activity.
本研究考虑制备一种具有红外活性腈基的新型DNA结合钌多吡啶配合物。一种新型钌络合物[Ru(TMP)2DPPZ-10-CN]与各种形式的DNA(包括规范和非规范)的结合能力通过多次DNA滴定进行了检测。DNA是非常有趣的,因为它是所有生物遗传信息的载体。对DNA的损伤会产生巨大的不利影响,因此对其结构和复制的研究具有重要意义。两个重要的非规范结构是g -四重体和i-基序,它们分别形成于基因的端粒和调控区域,并具有阻断端粒酶活性和影响转录的能力。该配合物采用微波辐照合成,并用二氧化硅柱和安百利石402离子交换纯化。然后,用鲑鱼精子dsDNA、鸟嘌呤单磷酸(GMP)、G4T4G4、人端粒g -四重体、i-motif C5T3和i-motif C30进行6次滴定。由于其高[bp]/[Ru]浓度,该配合物有利于非规范结构,特别是g -四复体结构。每个钌分子的碱基对或结构的浓度较高表明该配合物对特定的DNA结构具有较高的结合亲和力。这些结果支持钌金属配合物可用于诊断目的的概念,可用于靶向基因的端粒区域,在那里可以发现g -四重体结构,并影响转录起始和抑制端粒酶活性。
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引用次数: 0
The Use of Ruthenium Complexes as Molecular Probes for Non-Canonical DNA” by Eleni Sullivan 使用钌配合物作为非规范DNA的分子探针”,作者:Eleni Sullivan
Pub Date : 2022-01-01 DOI: 10.25172/jour.7.1.2
Eleni Sullivan
This study considered the preparation of a new DNA binding Ruthenium polypyridyl complex possessing an infrared active nitrile group. The binding abilities of a novel Ruthenium complex, [Ru(TMP)2DPPZ-10-CN], to various forms of DNA—both canonical and non-canonical—were examined by performing multiple DNA titrations. DNA is of great interest as it is the carrier of genetic information for all living things. Damage to DNA can have drastically detrimental effects, so the study of its structure and replication is of great importance. Two non-canonical structures that are important are the G-quadruplex and i-motif which form at the telomeric and regulatory regions of genes, respectively, and have the ability to block telomerase activity and influence transcription. The complex was synthesized by microwave irradiation and purified using a silica column and an ion exchange with Amberlite 402. Six titrations were, then, performed with salmon sperm dsDNA, guanine monophosphate (GMP), G4T4G4, human telomere G-quadruplex, i-motif C5T3, and i-motif C30. The complex was found to favor non-canonical structures, particularly the G-quadruplex structure, because of its high [bp]/[Ru] concentrations. The higher concentration of base pairs or structures per Ruthenium molecule indicated that the complex had a high binding affinity for that particular DNA structure. These results support the notion that Ruthenium metal complexes can be used for theragnostic purposes and can be used to target the telomeric region of genes where G-quadruplex structures can be found and influence transcription initiation and inhibit telomerase activity.
本研究考虑制备一种具有红外活性腈基的新型DNA结合钌多吡啶配合物。一种新型钌络合物[Ru(TMP)2DPPZ-10-CN]与各种形式的DNA(包括规范和非规范)的结合能力通过多次DNA滴定进行了检测。DNA是非常有趣的,因为它是所有生物遗传信息的载体。对DNA的损伤会产生巨大的不利影响,因此对其结构和复制的研究具有重要意义。两个重要的非规范结构是g -四重体和i-基序,它们分别形成于基因的端粒和调控区域,并具有阻断端粒酶活性和影响转录的能力。该配合物采用微波辐照合成,并用二氧化硅柱和安百利石402离子交换纯化。然后,用鲑鱼精子dsDNA、鸟嘌呤单磷酸(GMP)、G4T4G4、人端粒g -四重体、i-motif C5T3和i-motif C30进行6次滴定。由于其高[bp]/[Ru]浓度,该配合物有利于非规范结构,特别是g -四复体结构。每个钌分子的碱基对或结构的浓度较高表明该配合物对特定的DNA结构具有较高的结合亲和力。这些结果支持钌金属配合物可用于诊断目的的概念,可用于靶向基因的端粒区域,在那里可以发现g -四重体结构,并影响转录起始和抑制端粒酶活性。
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引用次数: 0
Rushes of Northcentral New Mexico 新墨西哥中北部的灯心草
Pub Date : 2022-01-01 DOI: 10.25172/jour.7.1.1
Madeline Payne
Juncaceae, otherwise known as rushes, are grass-like herbs that grow throughout North America in both arctic and temperate regions. The purpose of this monograph is to describe the 2 genera and 24 species of Juncaceae growing in northcentral New Mexico. Included is an introduction to the Juncaceae Family and the region of interest, reference maps, and a description of the materials and methods used to complete this research. Species description pages provide characteristics of the habit, leaves, flowers, fruit, and medicinal/culinary applications as well as pictures and diagrams. A key to the genera, keys to the species, a glossary, and an appendix with collected specimens are also included to increase ease of identifying plants of the Rush Family.
灯心草科,也被称为灯心草,是一种草状草本植物,生长在北美的北极和温带地区。本文描述了生长在美国新墨西哥州中北部的菊科植物2属24种。包括对菊花科和感兴趣的地区的介绍,参考地图,以及用于完成本研究的材料和方法的描述。物种描述页面提供了习性、叶子、花朵、果实和药用/烹饪应用的特征以及图片和图表。还包括属键、种键、词汇表和收集标本的附录,以方便识别拉什科植物。
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引用次数: 0
Imaging Analysis of Photoswitching Fluorophores Using Single-Imaging Analysis of Photoswitching Fluorophores Using Single-Molecule Microscopy Molecule Microsco 利用单分子显微镜对开关荧光团进行成像分析
Pub Date : 2021-04-01 DOI: 10.25172/JOUR.6.2.1
K. Binkley, Caleb Griffin
Single-molecule localization microscopy (SMLM) is a developing field of biological imaging that employs the use of photoswitching fluorophores to image sub-cellular biological structures at a higher resolution than was previously possible. These fluorophores are used for protein labeling, so that the sample can be imaged under fluorescence microscopy. This type of microscopy requires the use of many different types of fluorophores, which are fluorescent organic compounds that blink stochastically on and off. Thus, it is critical for developers in the field to have easy access to statistical models of the behaviors of different fluorophores. Here, we take AlexaFluor 647 and analyze it using a fluorescence microscope, taking data on its blinking behaviors and discerning its properties when immersed in a fluorescence-dampening buffer solution. We find that the compound behaves best in buffer solution, and we forge a new methodology for evaluating new fluorophores in a systematic fashion using readily available computer software.
单分子定位显微镜(SMLM)是生物成像的一个发展领域,它利用光电开关荧光团以比以前更高的分辨率成像亚细胞生物结构。这些荧光团用于蛋白质标记,以便在荧光显微镜下对样品进行成像。这种类型的显微镜需要使用许多不同类型的荧光团,这些荧光团是随机闪烁的荧光有机化合物。因此,对于该领域的开发人员来说,容易获得不同荧光团行为的统计模型是至关重要的。在这里,我们采用AlexaFluor 647,并使用荧光显微镜对其进行分析,获取其闪烁行为的数据,并识别其浸泡在荧光抑制缓冲溶液中的特性。我们发现该化合物在缓冲溶液中表现最好,并且我们建立了一种新的方法,可以使用现成的计算机软件以系统的方式评估新的荧光团。
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引用次数: 0
Unto One Man’s Hand: The Power of Portraiture of The Favorites of James I 一人之手:詹姆斯一世宠臣肖像的力量
Pub Date : 2021-04-01 DOI: 10.25172/JOUR.6.2.4
Maria Rosario Katsulos
This paper discusses the study and analysis of portraiture of the favorites of King James I: Esmé Stuart, Robert Carr, and George Villiers. Although famous female mistresses (such as Anne Boleyn before her queenship or Madame de Pompadour) often did wield immense political power, there is better historical documentation for the power of male favorites in politics, the military, economics, and other areas of national affairs. Studying visual primary source material allows a new perspective on contemporary thought and propaganda of the time. Certain aspects of character are better communicated through the intricate symbology of the time, and portraiture allows a perfect avenue to bringing those observations to light. The art forms discussed—official depictions as well as engraved prints, which were more easily disseminated to a wider public—had very different audiences and therefore carried different messages. By analyzing these works, we can draw new conclusions about the ways in which the contemporaries of the favorites, regardless of social status, perceived these men. "Reading” visual and written sources through a queer lens will also provide a depth of understanding missed by earlier sources, which have historically lacked that lens.
本文讨论了对英王詹姆斯一世最喜爱的三位人物的肖像画的研究和分析:艾斯米尔·斯图尔特、罗伯特·卡尔和乔治·维利尔斯。虽然著名的女性情妇(如安妮·博林在成为皇后之前或蓬巴杜夫人)经常拥有巨大的政治权力,但有更好的历史文献证明,男性情妇在政治、军事、经济和其他国家事务领域的权力。通过对视觉原始资料的研究,我们可以从一个新的角度来看待当代的思想和宣传。人物性格的某些方面通过当时复杂的符号学得到了更好的传达,而肖像画为这些观察提供了一个完美的途径。讨论的艺术形式——官方描绘和更容易传播给更广泛公众的雕刻版画——有着非常不同的受众,因此传递了不同的信息。通过分析这些作品,我们可以得出新的结论,即与最受欢迎的人同时代的人,无论社会地位如何,是如何看待这些人的。通过酷儿的视角“阅读”视觉和书面资料也将提供一种理解的深度,这是早期的资料所没有的,因为它们在历史上缺乏这种视角。
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引用次数: 0
The Weimar Republic and the War of Memory 魏玛共和国和记忆战争
Pub Date : 2021-04-01 DOI: 10.25172/JOUR.6.2.3
M. Dixon
World War I dismantled Imperial Germany and, long after the fighting had ceased, continued to shape the newly-born Weimar Republic. This paper argues that a war over the memory of the Great War in Germany led to Weimar’s downfall. The Weimar Republic’s lack of a collective memory of the first total war became the center of the political debate on the republic’s viability and Germany’s future. This war debate was potently wielded in the arenas of literature and art to heighten political conflict and ensure that the war’s memory seeped into every aspect of society. Ultimately, Weimar’s inability to promote any consensus on the war’s meaning in the face of opposition from the conservative and extremist right weakened the republic significantly and led to its downfall.
第一次世界大战瓦解了德意志帝国,在战争结束很久之后,它继续塑造着新生的魏玛共和国。本文认为,德国对第一次世界大战记忆的战争导致了魏玛的垮台。魏玛共和国缺乏对第一次全面战争的集体记忆,这成为了关于共和国生存能力和德国未来的政治辩论的中心。这场战争的辩论在文学和艺术领域被有力地运用,以加剧政治冲突,并确保战争的记忆渗透到社会的各个方面。最终,面对保守派和极右翼的反对,魏玛无法就战争的意义达成任何共识,这极大地削弱了共和国,并导致了它的垮台。
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引用次数: 0
Volume 6, Issue 1 Front Matter for Digital Publication 卷6,第1期前事项的数字出版
Pub Date : 2021-01-01 DOI: 10.25172/jour.6.1.7
Jessie M. Henderson
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引用次数: 0
A Legacy of Violence: The Lack of Transitional Justice in Post-Franco Spain and its Impact on Victimhood 暴力的遗产:后佛朗哥时代西班牙缺乏过渡正义及其对受害者的影响
Pub Date : 2021-01-01 DOI: 10.25172/JOUR.6.1.4
Hunter Kolon
In order for a country to transform from a society in which rights were severely repressed to a society in which rights are respected and protected, the violations of the past must be properly and adequately addressed. However, instead of using the transition to democracy to confront the country’s history of violence and repression, the Spanish government and society actively stifled the memory of the Civil War and forty-year dictatorship, failing to address the country’s legacy of violence and the victims left in its wake. Despite the Spanish transition being regarded as a remarkable success story, an institutionalized historical amnesia resulted in many oppositional counter-memories as forms of cultural resistance. This paper will demonstrate how repressing memory left the door open for the legacy of political violence to persist in Spain. Prioritizing processes of transitional justice and historical memory is crucial in working toward sustainable peace in Spain and the Basque Region today. This paper will provide an overview of transitional justice and historical memory and an analysis of the impact of Spain’s lack of transitional justice, specifically regarding the politicization of victimhood. It is important to examine the implications of the pacto del olivido (pact of silence) and the 1977 Amnesty Law in rendering Franco’s victims invisible and in sustaining Spain’s legacy of political violence. Furthermore, this paper will explore how the Basque terrorist group, Euskadi Ta Askatasuna (ETA), carried on Spain’s legacy of political violence for another four decades following the end of the Franco dictatorship. The next section of this paper will analyze how the ‘memory boom’ of the early 2000s led to greater recognition of the victims of Francoism and to the passing of the 2007 Historical Memory Law. This analysis will show how the politicization of victimhood resulted in an inequity between the measures taken to recognize and protect different victims’ groups, subsequently providing more protection for victims of ETA violence. Overall, this paper contends that, in the case of Spain, a lack of transitional justice has perpetuated a long legacy of violence and a silencing of the victims of Francoism that remain unresolved.
为了使一个国家从一个权利受到严重压制的社会转变为一个权利受到尊重和保护的社会,必须适当和充分地处理过去的侵犯行为。然而,西班牙政府和社会没有利用向民主的过渡来面对该国的暴力和镇压历史,而是积极地扼杀了内战和40年独裁统治的记忆,未能解决该国的暴力遗产和受害者。尽管西班牙的转型被认为是一个非凡的成功故事,制度化的历史健忘症导致了许多对立的反记忆作为文化抵抗的形式。本文将展示压抑的记忆如何为政治暴力的遗产在西班牙持续存在打开大门。优先考虑过渡正义和历史记忆的进程对于今天在西班牙和巴斯克地区实现可持续和平至关重要。本文将概述过渡时期的司法和历史记忆,并分析西班牙缺乏过渡时期司法的影响,特别是关于受害者的政治化。审视《沉默条约》(pacto del olivido)和1977年的《大赦法》(Amnesty Law)的影响是很重要的,它们使佛朗哥的受害者变得隐形,并维持了西班牙政治暴力的传统。此外,本文将探讨巴斯克恐怖组织Euskadi Ta Askatasuna (ETA)如何在佛朗哥独裁统治结束后的另一个四十年中继续西班牙的政治暴力遗产。本文的下一部分将分析21世纪初的“记忆热潮”如何导致对弗朗哥主义受害者的更多认识,以及2007年历史记忆法的通过。这一分析将显示,受害者意识的政治化如何导致承认和保护不同受害者群体的措施之间的不平等,从而为埃塔暴力的受害者提供更多的保护。总的来说,本文认为,在西班牙的情况下,缺乏过渡正义使长期遗留下来的暴力和弗朗哥主义受害者的沉默得以延续,这些问题仍未得到解决。
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引用次数: 2
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SMU Journal of Undergraduate Research
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