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Ketamine’s Role in Spirituality: How One Synthetic Drug Catalyzes a Natural Experience 氯胺酮在精神上的作用:一种合成药物如何催化自然体验
Pub Date : 2021-01-01 DOI: 10.25172/JOUR.6.1.6
Samiah Woods
This article highlights the potential spiritual effects of a popular anesthetic, ketamine, and how these spiritual effects can be used to help promote the reconciliation of spiritual and physical health. Ketamine, like the prominent psychedelic, psilocybin, has reportedly caused feelings of spiritual revelation and “out of body experiences” that many physicians may not feel qualified to discuss with their patients. This reluctance to address ketamine-induced spiritual experiences may affect the health outcomes of the patient. The primary goal of this project is to bring academic validity to considerations of the spiritual health of patients. This paper (1) investigates the extent that ketamine-induced, non-ordinary experiences can help bring awareness to the compatibility of spiritual and physical health and (2) compares the mechanisms of ketamine and psilocybin, as well as their value to the medical community due to the spiritual experiences that they catalyze. Thus, this research seeks to demonstrate that understanding the spiritual value of ketamine may encourage better communication between the physician and patient and promote more holistic healthcare approaches.
这篇文章强调了一种流行的麻醉剂氯胺酮的潜在精神影响,以及如何利用这些精神影响来帮助促进精神和身体健康的协调。据报道,氯胺酮和著名的迷幻药裸盖菇素(psilocybin)一样,会让人产生精神启示和“灵魂出窍”的感觉,许多医生可能觉得自己没有资格和病人讨论这些。这种不愿处理氯胺酮引起的精神体验可能会影响患者的健康结果。该项目的主要目标是将学术有效性引入对患者精神健康的考虑。本文(1)研究氯胺酮诱导的非寻常体验在多大程度上有助于意识到精神和身体健康的相容性;(2)比较氯胺酮和裸盖菇素的作用机制,以及它们因催化精神体验而对医学界的价值。因此,本研究试图证明,了解氯胺酮的精神价值可能会鼓励医生和病人之间更好的沟通,并促进更全面的医疗保健方法。
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引用次数: 0
Masdar City: A Study of Energy, Infrastructure, and Technological Hope Hope 马斯达尔城:能源、基础设施和技术希望的研究
Pub Date : 2021-01-01 DOI: 10.25172/JOUR.6.1.3
Aaron D'Eramo
The United Arab Emirates (UAE) has been a major supplier of fossil fuel for the world economy for decades, which has allowed the country to thrive economically. But global concerns over ecological destruction and climate change is prompting the UAE’s leaders to pursue alternative sources of energy. From this ecological fear, Masdar City was born, an ambitious project that hopes to create the world’s first “zero-carbon” emission city. The project’s goal is to utilize energy in a socially, economically, and environmentally sustainable system without sacrificing modern lifestyles. This case study will utilize theory on energy and infrastructures to analyze the implications of the project’s innovations, as well as to explore the rising intersection of neoliberalism and environmentalism to understand how a project like Masdar came to be. In 2016, ten years after its initial construction, the city still had not achieved net zero-carbon emissions, but a mere 50%. The project’s ambitions included the creation of a new energy-based currency to account for consumption, and the integration of a massive data vault that stores all consumption of energy.What is found is a complex and highly integrated information system that could lead to the selling of information and the corporate/governmental manipulation of data for control over populations.
几十年来,阿拉伯联合酋长国一直是世界经济的主要化石燃料供应国,这使得该国经济蓬勃发展。但全球对生态破坏和气候变化的担忧正促使阿联酋领导人寻求替代能源。出于这种生态恐惧,马斯达尔城诞生了,这是一个雄心勃勃的项目,希望创造世界上第一个“零碳”排放城市。该项目的目标是在不牺牲现代生活方式的情况下,在社会、经济和环境可持续的系统中利用能源。本案例研究将利用能源和基础设施理论来分析项目创新的含义,并探索新自由主义和环保主义的交叉点,以了解像马斯达尔这样的项目是如何产生的。2016年,在最初建设十年后,该市仍未实现净零碳排放,但仅为50%。该项目的目标包括创建一种新的基于能源的货币来计算消费,以及集成一个存储所有能源消费的大型数据库。所发现的是一个复杂和高度综合的信息系统,它可能导致出售信息和公司/政府操纵数据以控制人口。
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引用次数: 0
Raising Animals to Die for Profit: How Corporate America is Changing Human Animal Relationships in Rural America 饲养动物为利润而死:美国公司如何改变美国农村人与动物的关系
Pub Date : 2021-01-01 DOI: 10.25172/JOUR.6.1.5
Sabrina A. Brakke
Corporate ownership of livestock operations for meat and animal by-products has had a dramatic effect on human-animal relationships in rural areas of the United States. This evolution mandates mass production of livestock in large concentrated animal feed organizations (CAFO’s). In contrast, animal breeding for sport, such as hunting which also produces food, has not generated the same adverse effect on these relationships. In-depth, semi-structured interviews were conducted with two rural Iowa women, one raising livestock to be sold for meat and by-products; the other raising livestock to be hunted. Ferdinand Tonnies’ social groupings, gesellschaft and gemeinschaft, were used as theoretical concepts applied using inductive analysis. Findings suggest that, with corporate ownership, the human-animal interaction in these two groups are now very different from one another. The meat industry objectifies animals; they are a means to a financial end, a “product.” Hunting, which remains culturally rooted, allows for a closer relationship; the animal is still thought of as a living individual. The world must be fed and as consumers of these products, it is important to understand how corporate ownership of animals is changing the relationship between human and animals while other relationships resulting in animal meat remain steeped in tradition.
在美国的农村地区,牲畜生产的肉类和动物副产品的企业所有制对人与动物的关系产生了巨大的影响。这种演变要求大型集中动物饲料组织(CAFO)大规模生产牲畜。相比之下,为运动而饲养动物,例如也能生产食物的狩猎,并没有对这些关系产生同样的不利影响。对爱荷华州的两名农村妇女进行了深入的半结构化访谈,其中一名妇女饲养牲畜以出售肉类和副产品;另一种是饲养牲畜来猎杀。运用归纳分析的方法,将Ferdinand Tonnies的社会分组gesellschaft和gemeinschaft作为理论概念。研究结果表明,在公司所有权的情况下,这两个群体中的人与动物的互动现在非常不同。肉类工业将动物物化;它们是达到财务目的的一种手段,是一种“产品”。狩猎在文化上仍然根深蒂固,因此可以建立更紧密的关系;这种动物仍然被认为是有生命的个体。世界必须得到食物,作为这些产品的消费者,重要的是要了解企业对动物的所有权如何改变人与动物之间的关系,而导致动物肉的其他关系仍然沉浸在传统中。
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引用次数: 0
Analysis of Broadest Impact Implementation for a Developing Point of Care Device Using Antibody Antigen Reactions 使用抗体抗原反应的发展中的护理点设备的最广泛影响实施分析
Pub Date : 2021-01-01 DOI: 10.25172/JOUR.6.1.2
Sienna Dugan, Gabriella Gonzales, K. Little
With the recent launch of the Global Development Lab in the Hunter and Stephanie Hunt Institute for Engineering and Humanity, fellows, faculty, and industry professionals have been working to create meaningful solutions to promote a resilient humanity, addressing the UN’s Sustainable Development Goals and challenges. The Institute has taken on Dr. Ali Beskok’s project, the development of a low cost, portable, Point-of-Care-Device for humanitarian and health applications. This paper provides a systematic review of current Point-of-Care-Devices using antibody antigen reactions. Additionally, it provides aspects of a market analysis and a literature review. Its overarching goal is to make recommendations regarding a disease the developing device could test for through antibody antigen reactions that would most positively affect global health. Traditionally, biomedical engineers have developed technologies in response to the needs of the developed world’s medical community. These approaches often do not address the needs of the majority of the world’s peoples afflicted with both communicable and non-communicable diseases as the developments are far too costly and those with most need have, at best, limited access to supporting clinical laboratory infrastructure in developing countries. A gap in care has emerged as a result of these conditions. As a result, Drs. Beskok and Koklu have developed a Lab-on-a-Chip technology that can test for a chosen disease with a turnaround time of just a few seconds and a detection limit of 1 ng of antigen per 1 mL of sample fluid. In contrast to other commonly used PoCD’s, this technology can be adapted for detection of various diseases in various settings. This is a great improvement to current devices on the market in specificity, sensitivity, and ease of use, therefore making it particularly useful in high-throughput, low-skill staffing environments. In creating disease selection criteria for Dr. Beskok and his team’s device, several factors were taken into consideration. Generally, the selection criteria consists of diseases that result in a high DALY value, are communicable, identifiable with antibody-antigen reactions, and can be tested for using urine. The diseases that were identified with this criterion were Tuberculosis and Malaria. Various antibody-antigen recommendations for diagnosis, advantages, and limitations of the proposed Point-of-Care-Device are discussed in the Proposed Disease section. In addition, current funding for each disease is overviewed. In order to make the greatest impact, deployment of the PoCD in the Sub-Saharan region, most specifically the Democratic Republic of Congo and Sierra Leone are recommended. Furthermore, children under the age of 5 who suffer from malnutrition should be given special attention. Focusing in these locations and populations will best aid in accomplishing the third Sustainable Development Goal set out by the UN: to ensure healthy lives and promote wellbeing fo
随着亨特和斯蒂芬妮·亨特工程与人类研究所最近成立的全球发展实验室,研究员、教师和行业专业人士一直在努力创造有意义的解决方案,以促进有弹性的人类,应对联合国的可持续发展目标和挑战。研究所已接受了Ali Beskok博士的项目,即为人道主义和保健应用开发一种低成本、便携式护理点设备。本文提供了目前使用抗体抗原反应的护理点设备的系统综述。此外,它还提供了市场分析和文献综述的各个方面。它的首要目标是就开发中的设备可以通过抗体抗原反应检测的疾病提出建议,这将对全球健康产生最积极的影响。传统上,生物医学工程师开发技术是为了响应发达国家医学界的需求。这些办法往往不能满足世界上大多数传染病和非传染性疾病患者的需求,因为这些发展的成本太高,而最需要的人最多只能有限地获得发展中国家的支持性临床实验室基础设施。由于这些条件,在护理方面出现了差距。因此,dr。Beskok和Koklu开发了一种芯片实验室(Lab-on-a-Chip)技术,可以检测选定的疾病,周转时间仅为几秒钟,每1毫升样品液的抗原检测限为1 ng。与其他常用的PoCD相比,该技术可用于在各种环境中检测各种疾病。这是对市场上现有设备在特异性、灵敏度和易用性方面的巨大改进,因此使其在高通量、低技能人员配备环境中特别有用。在为Beskok博士和他的团队的设备创建疾病选择标准时,考虑了几个因素。一般来说,选择标准包括导致高DALY值的疾病,具有传染性,可通过抗体-抗原反应识别,并可通过尿液进行检测。根据这一标准确定的疾病是结核病和疟疾。建议的疾病部分讨论了用于诊断的各种抗体-抗原推荐,建议的护理点设备的优点和局限性。此外,还概述了目前每种疾病的供资情况。为了产生最大的影响,建议在撒哈拉以南地区,特别是刚果民主共和国和塞拉利昂部署PoCD。此外,患有营养不良的5岁以下儿童应得到特别关注。将重点放在这些地区和人群上,将最有助于实现联合国制定的第三个可持续发展目标:确保健康的生活方式,促进各年龄段所有人的福祉。
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引用次数: 0
When Dinosaurs Walked Through Diamonds: Constraining the Age of Early Cretaceous Footprints in Volcanic Crater Sediments 当恐龙走过钻石:限制火山口沉积物中早白垩纪脚印的年龄
Pub Date : 2021-01-01 DOI: 10.1130/abs/2020sc-343603
Yasmin Jackson
The volcanic rocks of the Catoca Diamond Mine, northeastern Angola, were formed in an eruption ~118 million years ago. Above these rocks, researchers discovered Early Cretaceous mammalian, crocodilian, and sauropod dinosaur footprints in crater lake sediments. These footprints are among the relatively few vertebrate fossils from the Cretaceous Period (145-66 million years ago) found in Sub-Saharan Africa. The ~118 million-year-old age, which is the maximum age of the footprints, is provided by the uranium and lead isotope ratios in the zircon crystals from these volcanic rocks. The presence of dinosaur footprints limits the minimum age to 66 million years ago. Detrital zircons from the sediments were collected for uranium-lead dating because these lake sediments may contain not only the ~118 million-year-old zircons but also zircons from younger eruptions, which could more precisely constrain the maximum age of these sediments. Forty zircons have been analyzed from this sediment sample, yielding an age range of 2.9 billion years ago to 150 million years ago. None of these zircons was ~118 million years old. Work is currently underway to find more zircons and to determine why no ~118 million-year-old zircons have been found in the lake bed sample.
安哥拉东北部卡托卡钻石矿的火山岩形成于1.18亿年前的一次喷发。在这些岩石之上,研究人员在火山口湖沉积物中发现了早白垩纪哺乳动物、鳄鱼和蜥脚类恐龙的脚印。这些脚印是在撒哈拉以南非洲发现的相对较少的白垩纪(1.45 - 6600万年前)脊椎动物化石之一。根据这些火山岩锆石晶体中的铀、铅同位素比值,确定了这些足迹的最大年龄约1.18亿年。恐龙脚印的存在将其最低年龄限制在6600万年前。从沉积物中收集碎屑锆石进行铀铅定年,因为这些湖泊沉积物中不仅可能含有~ 1.18亿年前的锆石,还可能含有更年轻喷发的锆石,这可以更精确地限制这些沉积物的最大年龄。从这个沉积物样本中分析了40颗锆石,得出了29亿到1.5亿年前的年龄范围。这些锆石的年龄都不超过1.18亿年。目前正在进行寻找更多锆石的工作,并确定为什么在湖床样本中没有发现1.18亿年前的锆石。
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引用次数: 0
Direct Ellipsoidal Fitting of Discrete Multi-Dimensional Data 离散多维数据的直接椭球拟合
Pub Date : 2019-01-16 DOI: 10.25172/JOUR.5.1.4
Rafey Anwar, M. Hamilton, P. Nadolsky
Multi-dimensional distributions of discrete data that resemble ellipsoids arise in numerous areas of science, statistics, and computational geometry. We describe a complete algebraic algorithm to determine the quadratic form specifying the equation of ellipsoid for the boundary of such multi-dimensional discrete distribution. In this approach, the equation of an ellipsoid is reconstructed using a set of matrix equations from low-dimensional projections of the input data. We provide a Mathematica program realizing the full implementation of the ellipsoid reconstruction algorithm in an arbitrary number of dimensions. To demonstrate its many potential uses, the direct reconstruction method is applied to quasi-Gaussian statistical distributions arising in elementary particle production at the Large Hadron Collider.
类似椭球体的离散数据的多维分布出现在科学、统计学和计算几何的许多领域。我们描述了一种确定这种多维离散分布边界的椭球方程二次型的完整代数算法。在这种方法中,利用输入数据的低维投影的一组矩阵方程来重建椭球的方程。我们提供了一个Mathematica程序,实现了在任意维数的椭球重建算法的完全实现。为了证明它的许多潜在用途,将直接重建方法应用于大型强子对撞机基本粒子产生中产生的准高斯统计分布。
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引用次数: 4
Volume 6, Issue 2 Digital Front Matter 第6卷,第2期数字前沿问题
Pub Date : 1900-01-01 DOI: 10.25172/jour.6.2.5
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引用次数: 0
Comics in Action: A Reflection of the Dominant Narrative in World War II 行动中的漫画:第二次世界大战中主导叙事的反映
Pub Date : 1900-01-01 DOI: 10.25172/JOUR.4.1.10
S. Gutierrez
In this paper, I argue that the propagandized use of comic books during World War II promoted views among Americans which contributed to antipathy towards Americans of Japanese and German descent. More generally, the goal of the essay is to highlight the importance of comic books as a reflection of the times – they simultaneously influence and are influenced by society’s dominant ideas – and promote the further study of such material. I examine the text and art from three comic book covers dated from 1942-1943. An analysis of these selections suggests that comic books depicted Axis soldiers as savage and animalistic, while Americans are portrayed as trustworthy heroes with whom the reader may easily identify. These conclusions are confirmed by various government sources, which claimed to have been teaching citizens about the war and the enemy, which in reality meant teaching citizens how to hate the enemy. Even more disturbing, comic books were read primarily by children, so these hateful ideas were spread to the most impressionable of all Americans. These very depictions, I argue, reflected and contributed to the general American sentiment towards the war, specifically in relation to the treatment of Japanese-Americans in internment camps and the use of atomic bombs in Nagasaki and Hiroshima. Further, the proliferation of comic books and the sole fact that they were used as a propaganda arm by the U.S. Government demonstrates their importance during the period and suggests that they be studied more to further understand their importance to American society.
在这篇论文中,我认为二战期间漫画书的宣传使用促进了美国人对日本和德国血统美国人的反感。更一般地说,这篇文章的目的是强调漫画书作为时代反映的重要性——它们同时影响着社会的主导思想,也被社会的主导思想所影响——并促进对这些材料的进一步研究。我研究了1942-1943年间三本漫画书封面的文字和艺术。这些结论得到了各种政府消息来源的证实,这些消息来源声称一直在教导公民关于战争和敌人的知识,而实际上这意味着教导公民如何憎恨敌人。更令人不安的是,漫画书主要是由儿童阅读的,所以这些可恨的想法传播给了所有美国人中最易受影响的人。我认为,正是这些描述反映并促成了美国人对战争的普遍情绪,特别是与在拘留营中对待日裔美国人以及在长崎和广岛使用原子弹有关的情绪。此外,漫画书的泛滥和它们被美国政府用作宣传工具的唯一事实表明了它们在这一时期的重要性,并建议对它们进行更多的研究,以进一步了解它们对美国社会的重要性。
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引用次数: 0
Investigating the Roles of RNA Binding Protein Combinations in Neuronal Function and Organismal Behavior 研究RNA结合蛋白组合在神经元功能和机体行为中的作用
Pub Date : 1900-01-01 DOI: 10.25172/JOUR.4.1.7
Alexa Vandenburg
The Norris lab recently identified two RNA binding proteins required for proper neuron-specific splicing. The lab conducted touch- response behavioral assays to assess the function of these proteins in touch-sensing neurons. After isolating C. elegans worms with specific phenotypes, the lab used automated computer tracking and video analysis to record the worms’ behavior. The behavior of mutant worms differed from that of wild-type worms.The Norris lab also discovered two possible RNA binding protein sites in SAD-1, a neuronal gene implicated in the neuronal development of C. elegans1. These two binding sites may control the splicing of SAD-1. The lab transferred mutated DNA into the genome of wild-type worms by injecting a mutated plasmid. The newly transformed worms fluoresced green, indicating that the two binding sites control SAD-1 splicing.
诺里斯实验室最近发现了两种RNA结合蛋白,它们是神经元特异性剪接所必需的。实验室进行了触摸反应行为分析,以评估这些蛋白质在触摸感应神经元中的功能。在分离出具有特定表型的秀丽隐杆线虫后,实验室使用自动计算机跟踪和视频分析来记录蠕虫的行为。突变型线虫的行为与野生型线虫不同。诺里斯实验室还在线虫的神经元发育过程中涉及的神经元基因sad1中发现了两个可能的RNA结合蛋白位点。这两个结合位点可能控制着ad -1的剪接。实验室通过注射突变的质粒将突变的DNA转移到野生型蠕虫的基因组中。新转化的蠕虫发出绿色荧光,表明这两个结合位点控制着萨德-1剪接。
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引用次数: 0
Informal Professional Development on Twitter: Exploring the Online Communities of Mathematics Educators 推特上的非正式专业发展:探索数学教育者的在线社区
Pub Date : 1900-01-01 DOI: 10.25172/JOUR5.1.3
Jaymie Ruddock
Professional development in its most traditional form is a classroom setting with a lecturer and an overwhelming amount of information. It is no surprise, then, that informal professional development away from institutions and on the teacher's own terms is a growing phenomenon due to an increased presence of educators on social media. These communities of educators use hashtags to broadcast to each other, with general hashtags such as #edchat having the broadest audience. However, many math educators use the hashtags #ITeachMath and #MTBoS, communities I was interested in learning more about. I built a Python script that used Tweepy to connect to Twitter's API, using try/except blocks to catch HTTP status codes that Twitter occasionally passes through the API. When it was finally completed, a sample of such tweets was collected and then processed using Python to determine polarity, objectivity, and word frequency, first as a group and then by choice of hashtag. Additional analysis included Latent Dirichlet Allocation and hierarchical clustering, and conversations between individuals were analyzed for topic and complexity to understand the extent of interactions. This information will be used to determine the extent of professional development (PD) that teachers do on Twitter simply by actively participating in such communities and ways to improve informal PD. It was determined that there is a significant amount of professional development opportunities on Twitter, but they are muddled by a lot of other content. Further research into the types and the frequency of collaborations on top of the existing latent topics could provide insight into the applications of informal professional development.
专业发展最传统的形式是一个有讲师和大量信息的教室。因此,由于越来越多的教育工作者出现在社交媒体上,因此,脱离机构、按照教师自己的意愿进行的非正式专业发展日益成为一种现象,也就不足为奇了。这些教育工作者社区使用标签相互广播,其中#edchat等通用标签拥有最广泛的受众。然而,许多数学教育者使用# itachmath和# mtbo标签,我对这些社区有兴趣了解更多。我构建了一个Python脚本,使用Tweepy连接到Twitter的API,使用try/except块捕获Twitter偶尔通过API传递的HTTP状态码。当它最终完成时,收集这些推文的样本,然后使用Python处理以确定极性,客观性和词频,首先作为一个组,然后通过选择标签。其他分析包括潜狄利克雷分配和分层聚类,并分析个体之间的对话的主题和复杂性,以了解互动的程度。这些信息将用于确定教师在Twitter上通过积极参与这些社区和改进非正式PD的方法来进行专业发展(PD)的程度。人们确定Twitter上有大量的职业发展机会,但它们被许多其他内容所混淆。在现有潜在主题的基础上进一步研究合作的类型和频率,可以深入了解非正式专业发展的应用。
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引用次数: 0
期刊
SMU Journal of Undergraduate Research
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