Pub Date : 2017-07-25DOI: 10.4172/2161-0932.1000444
P. Sirisha, R. Vottery, Lingaiah Amidyala, P. Nallari, A. Jyothy, A. Venkateshwari
Aim: Ovarian cancer (OC) occurs due to genetic alterations and mutations in BRCA gene. The aim of the study is to assess the frequency of genetic alterations that persist in Ashkenazi founder mutation BRCA1, 185delAG in patients with ovarian cancer from South Indian origin. Materials and Methods: A total of 100 ovarian cancer patients and an equal number of control subjects were included in the present study. Screening of 185delAG mutation BRCA1 gene was carried out by ARMS PCR followed by agarose gel electrophoresis. Statistical analysis was applied to test for the significance of the results obtained. Results: The genotype distribution of WW, WM, MM showed a significant difference between the two subjects, 95%, 4% and 1% in controls and 52%, 36% and 12% in cases respectively. An increased frequency of homozygotic mutant genotypes (MM) were found in patients compared to controls. Similarly, a significant difference in the distribution of M allele in cases and control subjects (W v/s M: χ2 P<0.0001, OR 18.06, 95% CI 6.31-51.65) was observed. Conclusion: The demographic details of the patients and controls revealed that females of age greater than 40 years are associated with high risk of ovarian cancer. The postmenopausal women have a very high susceptibility to OC (6.5 times riskier). Therefore, 185delAG mutation BRCA1 has a possible association in the etiology of ovarian cancer.
目的:卵巢癌(OC)是由于BRCA基因的改变和突变而发生的。该研究的目的是评估在南印度裔卵巢癌患者中，德系犹太人始祖突变brca1185delag持续存在的基因改变频率。材料与方法:本研究共纳入100例卵巢癌患者和同等数量的对照组。采用ARMS PCR技术筛选185delAG突变BRCA1基因，并进行琼脂糖凝胶电泳。应用统计学分析检验所得结果的显著性。结果:两组患者WW、WM、MM基因型分布差异有统计学意义，对照组为95%、4%、1%，病例为52%、36%、12%。与对照组相比，在患者中发现纯合子突变基因型(MM)的频率增加。同样，病例和对照组中M等位基因的分布也有显著差异(W v/s M: χ2 P<0.0001, OR 18.06, 95% CI 6.31-51.65)。结论:患者和对照组的人口统计资料显示，年龄大于40岁的女性患卵巢癌的风险较高。绝经后妇女对卵巢癌的易感性非常高(风险增加6.5倍)。因此，185delAG突变BRCA1与卵巢癌的病因学可能存在关联。
{"title":"Screening of BRCA 1 - 185delAG mutation in Ovarian Cancer patients in a Tertiary care centre from Telangana","authors":"P. Sirisha, R. Vottery, Lingaiah Amidyala, P. Nallari, A. Jyothy, A. Venkateshwari","doi":"10.4172/2161-0932.1000444","DOIUrl":"https://doi.org/10.4172/2161-0932.1000444","url":null,"abstract":"Aim: Ovarian cancer (OC) occurs due to genetic alterations and mutations in BRCA gene. The aim of the study is to assess the frequency of genetic alterations that persist in Ashkenazi founder mutation BRCA1, 185delAG in patients with ovarian cancer from South Indian origin. \u0000Materials and Methods: A total of 100 ovarian cancer patients and an equal number of control subjects were included in the present study. Screening of 185delAG mutation BRCA1 gene was carried out by ARMS PCR followed by agarose gel electrophoresis. Statistical analysis was applied to test for the significance of the results obtained. \u0000Results: The genotype distribution of WW, WM, MM showed a significant difference between the two subjects, 95%, 4% and 1% in controls and 52%, 36% and 12% in cases respectively. An increased frequency of homozygotic mutant genotypes (MM) were found in patients compared to controls. Similarly, a significant difference in the distribution of M allele in cases and control subjects (W v/s M: χ2 P<0.0001, OR 18.06, 95% CI 6.31-51.65) was observed. \u0000Conclusion: The demographic details of the patients and controls revealed that females of age greater than 40 years are associated with high risk of ovarian cancer. The postmenopausal women have a very high susceptibility to OC (6.5 times riskier). Therefore, 185delAG mutation BRCA1 has a possible association in the etiology of ovarian cancer.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"8 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-07-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90563558","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-30DOI: 10.4172/2161-0932.1000441
Hounkponou Nfm, Komongui Gd, K. Salifou, Adjalla Amc, Ahouingnan Ay, S. Gbevo, M. Vodouhè, O. Aaa, R. SidiImorou, T. Ja, M. Aboubakar, R. Perrin
Objective: To investigate the possibility of vaginal birth after two caesarean deliveries. Patients and methods: This was a cross-sectional analytical study with prospective data collection, conducted from March 1st to September 30th 2016, in three maternities in reference hospitals in the Borgou department, Republic of Benin. Results: Of the 162 patients registered, 87 (53.70%) began spontaneous labour and 75 (46.30%) benefited from a C-section before labour began. Of the 87 women who started spontaneous labour, 54 (62.07%) did not meet the requirements for vaginal birth, and benefited from a C-section; one patient (1.15%) gave birth in the course of referral, and 32 (36.78%) went through our trial. Of the 32 patients who went through the trial of scar, 28 (87.50%) delivered successfully; among them were two twin pregnancies. All four unsuccessful trials (12.50%) were due to the occurrence of acute fetal distress. Among the 28 successful cases, 03 (10.71%) developed to a vasculo-renal syndrome in the sequences of immediate layers. We encountered no case of scar dehiscence nor of child nor maternal death. Conclusion: Vaginal birth in double scarred uterus is possible and can be considered, with minimum damage to the mother and the fetus. Nevertheless, the recruitment of subjects must be rigorous and labour surveillance done in a surgical environment.
{"title":"Childbirth by Vaginal Delivery in Double Scarred Uterus: Uterine Trial Conducted in the Borgou Department, Benin","authors":"Hounkponou Nfm, Komongui Gd, K. Salifou, Adjalla Amc, Ahouingnan Ay, S. Gbevo, M. Vodouhè, O. Aaa, R. SidiImorou, T. Ja, M. Aboubakar, R. Perrin","doi":"10.4172/2161-0932.1000441","DOIUrl":"https://doi.org/10.4172/2161-0932.1000441","url":null,"abstract":"Objective: To investigate the possibility of vaginal birth after two caesarean deliveries. \u0000Patients and methods: This was a cross-sectional analytical study with prospective data collection, conducted from March 1st to September 30th 2016, in three maternities in reference hospitals in the Borgou department, Republic of Benin. \u0000Results: Of the 162 patients registered, 87 (53.70%) began spontaneous labour and 75 (46.30%) benefited from a C-section before labour began. Of the 87 women who started spontaneous labour, 54 (62.07%) did not meet the requirements for vaginal birth, and benefited from a C-section; one patient (1.15%) gave birth in the course of referral, and 32 (36.78%) went through our trial. Of the 32 patients who went through the trial of scar, 28 (87.50%) delivered successfully; among them were two twin pregnancies. All four unsuccessful trials (12.50%) were due to the occurrence of acute fetal distress. Among the 28 successful cases, 03 (10.71%) developed to a vasculo-renal syndrome in the sequences of immediate layers. We encountered no case of scar dehiscence nor of child nor maternal death. \u0000Conclusion: Vaginal birth in double scarred uterus is possible and can be considered, with minimum damage to the mother and the fetus. Nevertheless, the recruitment of subjects must be rigorous and labour surveillance done in a surgical environment.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"58 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73860428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-30DOI: 10.4172/2161-0932.1000443
S. Mok, Jae Hoon Kim, S. Skates, J. Schorge, D. Cramer, K. Lu, C. Liew
Purpose: To identify candidate genomic signatures for the early detection of ovarian cancer using whole bloodbased gene expression profiles. Experimental Design: We performed Affymetrix U133Plus 2.0 GeneChip microarray analyses on whole blood RNA samples obtained from 14 ovarian cancer patients and 15 age-matched, healthy women. Genes differentially expressed were identified using a parametric Welch t-test. Real-time qRT-PCR analyses were performed on RNA prepared from 96 ovarian cancer patients and 83 age-matched healthy women, using primer sets specific for 14 genes. A Mann Whitney U test assessed individual gene significance. CA125 levels were determined in the same set of samples. We used logistic regression analyses and cross validation to assess the ability of linear combinations of specific transcripts combined with CA125 to distinguish cancer from controls. Results: Microarray analyses showed that 9583 probes were significantly different in blood gene expression profiles from healthy women as compared with those from ovarian cancer patients (p<0.05). Real-time RT-PCR analyses on the 96 cases and 83 controls validated 7 genes, which showed significantly different expression levels in cases and controls. Logistic regression analyses and cross validation identified an optimal panel of markers including CA125, BRCA1, and KIAA0562, that could improve the sensitivity of CA125 alone to over 90% at 98% specificity in the detection of early stage ovarian cancer. Conclusion: Circulating blood gene expression profiles identified RNA markers that can improve the sensitivity of CA125 in the detection of early stage ovarian cancer. Further validation is warranted to confirm the clinical usefulness of these biomarkers.
{"title":"Use of Blood-based mRNA profiling to Identify Biomarkers for Ovarian Cancer Screening","authors":"S. Mok, Jae Hoon Kim, S. Skates, J. Schorge, D. Cramer, K. Lu, C. Liew","doi":"10.4172/2161-0932.1000443","DOIUrl":"https://doi.org/10.4172/2161-0932.1000443","url":null,"abstract":"Purpose: To identify candidate genomic signatures for the early detection of ovarian cancer using whole bloodbased \u0000 gene expression profiles. \u0000Experimental Design: We performed Affymetrix U133Plus 2.0 GeneChip microarray analyses on whole blood \u0000 RNA samples obtained from 14 ovarian cancer patients and 15 age-matched, healthy women. Genes differentially \u0000 expressed were identified using a parametric Welch t-test. Real-time qRT-PCR analyses were performed on RNA \u0000 prepared from 96 ovarian cancer patients and 83 age-matched healthy women, using primer sets specific for 14 \u0000 genes. A Mann Whitney U test assessed individual gene significance. CA125 levels were determined in the same set \u0000 of samples. We used logistic regression analyses and cross validation to assess the ability of linear combinations of \u0000 specific transcripts combined with CA125 to distinguish cancer from controls. \u0000Results: Microarray analyses showed that 9583 probes were significantly different in blood gene expression \u0000 profiles from healthy women as compared with those from ovarian cancer patients (p<0.05). Real-time RT-PCR \u0000 analyses on the 96 cases and 83 controls validated 7 genes, which showed significantly different expression levels \u0000 in cases and controls. Logistic regression analyses and cross validation identified an optimal panel of markers \u0000 including CA125, BRCA1, and KIAA0562, that could improve the sensitivity of CA125 alone to over 90% at 98% \u0000 specificity in the detection of early stage ovarian cancer. \u0000Conclusion: Circulating blood gene expression profiles identified RNA markers that can improve the sensitivity \u0000 of CA125 in the detection of early stage ovarian cancer. Further validation is warranted to confirm the clinical \u0000 usefulness of these biomarkers.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"2 1","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87141040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-30DOI: 10.4172/2161-0932.1000442
M. Wedin, E. Lindqvist, M. Fredrikson, P. Kjølhede
Volume 7 • Issue 6 • 1000442 Gynecol Obstet (Sunnyvale), an open access journal ISSN: 2161-0932 Lymphedema development after cancer treatment in women with endometrial cancer is a poorly explored complication and there is a substantial gap in the knowledge of this troublesome treatmentrelated adverse effect. Endometrial cancer is the most common gynecological cancer. The majority of the women diagnosed with endometrial cancer will be long-term survivors. The primary treatment of endometrial cancer most often comprises hysterectomy and bilateral salpingo-oophorectomy. Pelvic and para-aortic lymphadenectomy is recommended in prognostic high-risk groups of endometrial cancer. Lymphedema development is associated with lymphadenectomy.
{"title":"Short commentary on Lymphedema after Treatment for Endometrial Cancer","authors":"M. Wedin, E. Lindqvist, M. Fredrikson, P. Kjølhede","doi":"10.4172/2161-0932.1000442","DOIUrl":"https://doi.org/10.4172/2161-0932.1000442","url":null,"abstract":"Volume 7 • Issue 6 • 1000442 Gynecol Obstet (Sunnyvale), an open access journal ISSN: 2161-0932 Lymphedema development after cancer treatment in women with endometrial cancer is a poorly explored complication and there is a substantial gap in the knowledge of this troublesome treatmentrelated adverse effect. Endometrial cancer is the most common gynecological cancer. The majority of the women diagnosed with endometrial cancer will be long-term survivors. The primary treatment of endometrial cancer most often comprises hysterectomy and bilateral salpingo-oophorectomy. Pelvic and para-aortic lymphadenectomy is recommended in prognostic high-risk groups of endometrial cancer. Lymphedema development is associated with lymphadenectomy.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2017-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81655474","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-15DOI: 10.4172/2161-0932.1000440
Neha Muniyar, Vidya Kamble, Sushil Kumar
Intra-uterine fetal growth restriction (IUGR) is an important and common cause of neonatal morbidity and mortality. It is a multifactorial phenomenon including many maternal and fetal factors. This study is a retrospective observational study carried out in tertiary care centre which mainly receives referral cases and patients from poor socio economic background .Our study included the patients who were antenatally diagnosed as having IUGR fetus on basis of ultrasound findings and later delivered a baby weighing less than 2.5 kg. The study assessed the maternal and fetal outcome of IUGR pregnancies. The incidence of Intra-uterine growth restriction in our study was 4%. The pregnancy induced hypertension (PIH) was the most common factor associated with IUGR. The 60% of the IUGR neonates required admission to neonatal ICU. The majority of those admitted to neonatal ICU were born to mothers without adequate antenatal care. We concluded that apart from PIH, anemia, poor weight gain during pregnancy and the poor antenatal period care were major risk factors for IUGR.
{"title":"IUGR Pregnancies - Feto-Maternal Outcome","authors":"Neha Muniyar, Vidya Kamble, Sushil Kumar","doi":"10.4172/2161-0932.1000440","DOIUrl":"https://doi.org/10.4172/2161-0932.1000440","url":null,"abstract":"Intra-uterine fetal growth restriction (IUGR) is an important and common cause of neonatal morbidity and mortality. It is a multifactorial phenomenon including many maternal and fetal factors. This study is a retrospective observational study carried out in tertiary care centre which mainly receives referral cases and patients from poor socio economic background .Our study included the patients who were antenatally diagnosed as having IUGR fetus on basis of ultrasound findings and later delivered a baby weighing less than 2.5 kg. The study assessed the maternal and fetal outcome of IUGR pregnancies. The incidence of Intra-uterine growth restriction in our study was 4%. The pregnancy induced hypertension (PIH) was the most common factor associated with IUGR. The 60% of the IUGR neonates required admission to neonatal ICU. The majority of those admitted to neonatal ICU were born to mothers without adequate antenatal care. We concluded that apart from PIH, anemia, poor weight gain during pregnancy and the poor antenatal period care were major risk factors for IUGR.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"21 1","pages":"1-3"},"PeriodicalIF":0.0,"publicationDate":"2017-06-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89267294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-06-01DOI: 10.4172/2161-0932.1000439
N. Gultekin
Background: Was the operation time of the second caesarean section affected from the technics of the operation in the first caesarean section. Objectives: We estimated that the operation time in the second caesarean section would be more longer by non-closing of the parietal peritoneum than the closure. Firstly, the non-closure of the parietal peritoneum was seemed to gain time during the first caesarean section. However we compared the operation time of the second caesarean section of non-closure and closure. Study design: This was a retrospective study. The study had two groups of the second caesarean sections of patients who had closure and non- closure of parietal peritoneum in the first caesarean section. The closure of pariatel peritoneum was control group with 1308 patients and the non-closure of any peritoneum was case group with 740 patients. In the both groups, the operation time and the amount of the adhesions of the omentum to the scarpa fascia were compared. Result: The nonclosure of the parietal peritoneum may gain time during the first operation but the nonclosure will casues the more adhesions of omentum to the scarpa fascia and the time of the second repeated caesarean will be longer. For this reason , the recover in second operation will be late in non- closure patients. Conclusion: This study was very important experiment about operation tehcniques with doing the second operation to the same patients. This study should be done in multiple centers with more number of patients in the World.
{"title":"The Closure Non Closure of the Parietal Peritoneum in the Caeserean Section","authors":"N. Gultekin","doi":"10.4172/2161-0932.1000439","DOIUrl":"https://doi.org/10.4172/2161-0932.1000439","url":null,"abstract":"Background: Was the operation time of the second caesarean section affected from the technics of the operation in the first caesarean section. \u0000Objectives: We estimated that the operation time in the second caesarean section would be more longer by non-closing of the parietal peritoneum than the closure. Firstly, the non-closure of the parietal peritoneum was seemed to gain time during the first caesarean section. However we compared the operation time of the second caesarean section of non-closure and closure. \u0000Study design: This was a retrospective study. The study had two groups of the second caesarean sections of patients who had closure and non- closure of parietal peritoneum in the first caesarean section. The closure of pariatel peritoneum was control group with 1308 patients and the non-closure of any peritoneum was case group with 740 patients. In the both groups, the operation time and the amount of the adhesions of the omentum to the scarpa fascia were compared. \u0000Result: The nonclosure of the parietal peritoneum may gain time during the first operation but the nonclosure will casues the more adhesions of omentum to the scarpa fascia and the time of the second repeated caesarean will be longer. For this reason , the recover in second operation will be late in non- closure patients. \u0000Conclusion: This study was very important experiment about operation tehcniques with doing the second operation to the same patients. This study should be done in multiple centers with more number of patients in the World.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"AES-14 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84542939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-26DOI: 10.4172/2161-0932.1000438
Yesuf Ahmed Aragaw, Mintesnot Mahtemsilllasie, Habtamu Jarso
Introduction: The term ‘Grand-multiparity’ was introduced by Solomon (1934), who called it the “dangerous multipara” [1]. Since then grand multiparity has been considered as a risk factor for both mother and the fetus [1-4]. The International Federation of Gynecology and Obstetrics define grand multiparity as delivery of the fifth or more newborn and in this study grand multiparity is defined when a pregnant woman have five or more births above the gestational age of 28 weeks [2]. The objective of this study is to compare maternal and perinatal outcome in grand multiparity and low parity. In developing countries grand multiparity is very common while in developed countries rare. Methods and materials: Prospective cross sectional comparative study was done in Jimma University specialized Hospital in 2015. Data was collected from119 grand multiparous (parity >= 5) and 238 low parity (parity2-4) women who gave birth in the hospital and data were analyzed by using statically package social science (spss) 20.3. p-value<0.05 considered significant. Result: There were 357 parous women participated in the study, among then 125 were grand multiparous making the incidence 8%. Grand multiparty was associated with anemia (3.5; 1.5-8.4), nonreassuring fetal condition intraparum (3.2; 1.3-8.0) and perinatal mortality (5; 1.7-7.4). Conclusion: Grand multiparty was associated both maternal and perinatal mortality and morbidity. Limiting parity might decrease both maternal and perinatal mortality and both at community and health facility family planning awareness should be made.
引言:“大多重奇偶”一词是由Solomon(1934)提出的，他称之为“危险的多重奇偶”[1]。从那时起，多胎被认为是母亲和胎儿的危险因素[1-4]。国际妇产科联合会(International Federation of Gynecology and Obstetrics)将大多胎定义为分娩第五胎及以上新生儿，本研究将大多胎定义为孕妇在孕龄28周以上分娩五胎及以上[2]。本研究的目的是比较大胎次和低胎次的产妇和围产期结局。在发展中国家，大多胎非常普遍，而在发达国家则很少见。方法与材料:2015年在吉马大学专科医院进行前瞻性横断面比较研究。收集在医院分娩的119例大胎次(胎次>= 5)和238例低胎次(胎次2-4)产妇的资料，采用spss统计软件包20.3对数据进行分析。p值<0.05认为显著。结果:本组共有357例产妇参加本研究，其中大产125例，发生率为8%。大多方与贫血相关(3.5;1.5-8.4)，分娩时胎儿状况不稳定(3.2;1.3-8.0)和围产期死亡率(5;1.7 - -7.4)。结论:大多方因素与孕产妇及围产儿死亡率和发病率有关。限制胎次可能会降低孕产妇和围产期死亡率，社区和保健设施都应提高计划生育意识。
{"title":"Grand Multiparity and Pregnancy Related Complications among Women Who Gave Birth at Jimma University Specialized Hospital, Jimma, Southwest Ethiopia","authors":"Yesuf Ahmed Aragaw, Mintesnot Mahtemsilllasie, Habtamu Jarso","doi":"10.4172/2161-0932.1000438","DOIUrl":"https://doi.org/10.4172/2161-0932.1000438","url":null,"abstract":"Introduction: The term ‘Grand-multiparity’ was introduced by Solomon (1934), who called it the “dangerous multipara” [1]. Since then grand multiparity has been considered as a risk factor for both mother and the fetus [1-4]. The International Federation of Gynecology and Obstetrics define grand multiparity as delivery of the fifth or more newborn and in this study grand multiparity is defined when a pregnant woman have five or more births above the gestational age of 28 weeks [2]. The objective of this study is to compare maternal and perinatal outcome in grand multiparity and low parity. In developing countries grand multiparity is very common while in developed countries rare. \u0000Methods and materials: Prospective cross sectional comparative study was done in Jimma University specialized Hospital in 2015. Data was collected from119 grand multiparous (parity >= 5) and 238 low parity (parity2-4) women who gave birth in the hospital and data were analyzed by using statically package social science (spss) 20.3. p-value<0.05 considered significant. \u0000Result: There were 357 parous women participated in the study, among then 125 were grand multiparous making the incidence 8%. Grand multiparty was associated with anemia (3.5; 1.5-8.4), nonreassuring fetal condition intraparum (3.2; 1.3-8.0) and perinatal mortality (5; 1.7-7.4). \u0000Conclusion: Grand multiparty was associated both maternal and perinatal mortality and morbidity. Limiting parity might decrease both maternal and perinatal mortality and both at community and health facility family planning awareness should be made.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"2 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2017-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83344394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-05-15DOI: 10.4172/2161-0932.1000437
R. Rani, U. Singh, V. Trivedi, R. Chauhan, A. Kumari
Globally uterine cervix cancer is one of the leading causes of death in females due to cancer, especially in developing countries. The aim of the study was to analyse the survival as well as understanding various prognostic factors for survival in patients of carcinoma cervix presenting in our hospital. A total of 508 patients were evaluated in radiotherapy department of Mahavir Cancer Sansthan and Research centre Patna, Bihar who came for follow up between April 2015 to March 2016 after completion of radical radiotherapy. Out of 508 patients 3.54% (n 18), 71.65% (n 364), 22.83% (n 116) and 1.9% (n 10) patients presented in sage I, II, III and IV A respectively. 53.54% of patients belonged to age group of 35 to 50 years with Survival of 937 ± 53.49 days. 46.46% of the patients were more than 50 years age and their survival was 933.3 ± 57.12 days. The mean duration for overall survival for all cases evaluated was 957.4 ± 39.49 days. The mean duration for survival of stages I, II, III and IVA was 1186 ± 281.8 days, 960 ± 85.04 days, 945.1 ± 45.66 days and 765 ± 181.5 days respectively. Survival of patients having squamous cell carcinoma was 970 ± 42.89 days and that of adenocarcinoma was 669.5 ± 120 days and that of premenopausal and postmenopausal lady was 997.5 ± 79.28 and 940.1 ± 45.39 days respectively. It was evident from study that patients who presented in early stage had a better survival. There was no significant difference in survival of cervix cancer patients in different age groups while survival was greater in premenopausal cervical cancer patients.
{"title":"Determinants of Survival of Cervical Cancer: A Hospital Based Study","authors":"R. Rani, U. Singh, V. Trivedi, R. Chauhan, A. Kumari","doi":"10.4172/2161-0932.1000437","DOIUrl":"https://doi.org/10.4172/2161-0932.1000437","url":null,"abstract":"Globally uterine cervix cancer is one of the leading causes of death in females due to cancer, especially in developing countries. The aim of the study was to analyse the survival as well as understanding various prognostic factors for survival in patients of carcinoma cervix presenting in our hospital. A total of 508 patients were evaluated in radiotherapy department of Mahavir Cancer Sansthan and Research centre Patna, Bihar who came for follow up between April 2015 to March 2016 after completion of radical radiotherapy. Out of 508 patients 3.54% (n 18), 71.65% (n 364), 22.83% (n 116) and 1.9% (n 10) patients presented in sage I, II, III and IV A respectively. 53.54% of patients belonged to age group of 35 to 50 years with Survival of 937 ± 53.49 days. 46.46% of the patients were more than 50 years age and their survival was 933.3 ± 57.12 days. The mean duration for overall survival for all cases evaluated was 957.4 ± 39.49 days. The mean duration for survival of stages I, II, III and IVA was 1186 ± 281.8 days, 960 ± 85.04 days, 945.1 ± 45.66 days and 765 ± 181.5 days respectively. Survival of patients having squamous cell carcinoma was 970 ± 42.89 days and that of adenocarcinoma was 669.5 ± 120 days and that of premenopausal and postmenopausal lady was 997.5 ± 79.28 and 940.1 ± 45.39 days respectively. It was evident from study that patients who presented in early stage had a better survival. There was no significant difference in survival of cervix cancer patients in different age groups while survival was greater in premenopausal cervical cancer patients.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"60 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77197595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-29DOI: 10.4172/2161-0932.1000436
A. Ajayi, B. Afolabi, V. Ajayi, Oluwafunmilola Biobabu, I. Oyetunji, H. Aikhuele, A. Sohoni
Background: Intrauterine adhesions are associated with certain uterine procedures such as dilatation and curettage, open myomectomy and Cesarean section as well as some infections. Objectives: To determine the most important risk factors for intrauterine adhesions among Black Africans Study design, setting and subjects: This was a retrospective study conducted at Nordica Fertility Center (NFC). A total of 905 patients from three cities - Lagos, Abuja and Asaba, who consulted for infertility related problems and on whom hysteroscopy was performed between January 2005 and November 2014, were studied. Main outcome measures: Performance of different uterine surgeries, type and number of different uterine surgeries performed, and presence or absence of intrauterine adhesions. Results: A total of 905 women on whom hysteroscopy was performed were included in the study among whom 264 (29.2%) were positive for intrauterine adhesions. Women with IUA were significantly older (t=5.34, P-value=0.00001) than those without IUA. IUA was common among women who were Chief Executives (21/52, 40.4%). The overall mean [± sd] number of myomectomy (0.58 [0.66]) and of D&C (1.68 [1.82]) were significantly higher in IUA-positive women than in IUA-negative women (t=10.66, P-value=0.000001; t=4.52, P-value=0.00001). The ratio of D&C per woman was 1.70 per woman in IUA-positive women compared to 1.1 per woman in IUA negative women. Women with IUA were about 2½ times more likely to have had open myomectomy than those without IUA (Crude odds ratio=2.36, 95% CI:1.75, 3.16) and were just about twice as likely to have had D&C compared to those without IUA (Crude odds ratio=1.92, 95% CI:1.42, 2.60). Correlation coefficient study indicates that IUA was significantly (P-value<0.05) associated with performing all uterine and adnexal operations especially D&C (r=0.023, t=4.42), open myomectomy (r=0.017, t=3.45), Cesarean section (r=0.037, t=4.39), ovarian cystectomy (r=0.06, t=4.86) and salpingectomy (r=0.111, t=6.37). When the number of uterine surgeries performed was considered, IUA significantly (P-value<0.05) correlated with age (r=0.097, t=12.42), Body Mass Index (r=0.162, t=15.45), and with the number of D&C performed (r=0.014, t=2.16). Conclusion: Uterine procedures like open myomectomy, Dilatation and Curettage and Caesarean section as well as adnexeal surgeries and the number of times these procedures are carried out are important risk factors for uterine adhesions in infertile black African women. Mitigating these risk factors can help reduce the incidence of intrauterine adhesions in these women and improve their fertility.
{"title":"Risk Factors for Intrauterine Adhesions in a Black African Population - Nigerians","authors":"A. Ajayi, B. Afolabi, V. Ajayi, Oluwafunmilola Biobabu, I. Oyetunji, H. Aikhuele, A. Sohoni","doi":"10.4172/2161-0932.1000436","DOIUrl":"https://doi.org/10.4172/2161-0932.1000436","url":null,"abstract":"Background: Intrauterine adhesions are associated with certain uterine procedures such as dilatation and \u0000 curettage, open myomectomy and Cesarean section as well as some infections. \u0000Objectives: To determine the most important risk factors for intrauterine adhesions among Black Africans \u0000Study design, setting and subjects: This was a retrospective study conducted at Nordica Fertility Center \u0000 (NFC). A total of 905 patients from three cities - Lagos, Abuja and Asaba, who consulted for infertility related problems \u0000 and on whom hysteroscopy was performed between January 2005 and November 2014, were studied. \u0000Main outcome measures: Performance of different uterine surgeries, type and number of different uterine \u0000 surgeries performed, and presence or absence of intrauterine adhesions. \u0000Results: A total of 905 women on whom hysteroscopy was performed were included in the study among whom 264 \u0000 (29.2%) were positive for intrauterine adhesions. Women with IUA were significantly older (t=5.34, P-value=0.00001) \u0000 than those without IUA. IUA was common among women who were Chief Executives (21/52, 40.4%). The overall \u0000 mean [± sd] number of myomectomy (0.58 [0.66]) and of D&C (1.68 [1.82]) were significantly higher in IUA-positive \u0000 women than in IUA-negative women (t=10.66, P-value=0.000001; t=4.52, P-value=0.00001). The ratio of D&C per \u0000 woman was 1.70 per woman in IUA-positive women compared to 1.1 per woman in IUA negative women. Women \u0000 with IUA were about 2½ times more likely to have had open myomectomy than those without IUA (Crude odds \u0000 ratio=2.36, 95% CI:1.75, 3.16) and were just about twice as likely to have had D&C compared to those without \u0000 IUA (Crude odds ratio=1.92, 95% CI:1.42, 2.60). Correlation coefficient study indicates that IUA was significantly \u0000 (P-value<0.05) associated with performing all uterine and adnexal operations especially D&C (r=0.023, t=4.42), \u0000 open myomectomy (r=0.017, t=3.45), Cesarean section (r=0.037, t=4.39), ovarian cystectomy (r=0.06, t=4.86) and \u0000 salpingectomy (r=0.111, t=6.37). When the number of uterine surgeries performed was considered, IUA significantly \u0000 (P-value<0.05) correlated with age (r=0.097, t=12.42), Body Mass Index (r=0.162, t=15.45), and with the number of \u0000 D&C performed (r=0.014, t=2.16). \u0000Conclusion: Uterine procedures like open myomectomy, Dilatation and Curettage and Caesarean section as \u0000 well as adnexeal surgeries and the number of times these procedures are carried out are important risk factors for \u0000 uterine adhesions in infertile black African women. Mitigating these risk factors can help reduce the incidence of \u0000 intrauterine adhesions in these women and improve their fertility.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"10 1","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2017-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91271277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2017-04-23DOI: 10.4172/2161-0932.1000435
M. Aboubakar, Roger Klikpezo, M. Tognifode, J. Denakpo, F. Zouari, A. A. Obossou
There is now a consensus on the need to provide healthcare, before and during pregnancy, to women at high risks of APS related obstetric complications diagnosed based on their medical (thrombosis) or obstetric (repeated embryo-fetal losses) history. However, the best therapeutic options are yet to be agreed upon. This study presents the experience of the Departement C of the Maternity and neonatology Center of Tunis (CMNT), a tertiary hospital in managing this pathology. Patients and methodologies: This is a five-year descriptive retrospective study of cases reported to CMNT maternity department. Outcome: 34 patients records were analyzed. The average age of the patients was 32 years with extremes of 21 and 44 years. The therapeutic option was a combination of acetyl salicylic acid and low molecular weight heparin. The success rate of the treatment was 97% full-term pregnancies against 12% without treatment.
{"title":"Pregnancy Outcome of Women with Antiphospholipid Syndrome, a Retrospective Descriptive Case Study","authors":"M. Aboubakar, Roger Klikpezo, M. Tognifode, J. Denakpo, F. Zouari, A. A. Obossou","doi":"10.4172/2161-0932.1000435","DOIUrl":"https://doi.org/10.4172/2161-0932.1000435","url":null,"abstract":"There is now a consensus on the need to provide healthcare, before and during pregnancy, to women at high \u0000 risks of APS related obstetric complications diagnosed based on their medical (thrombosis) or obstetric (repeated \u0000 embryo-fetal losses) history. However, the best therapeutic options are yet to be agreed upon. This study presents \u0000 the experience of the Departement C of the Maternity and neonatology Center of Tunis (CMNT), a tertiary hospital in \u0000 managing this pathology. \u0000Patients and methodologies: This is a five-year descriptive retrospective study of cases reported to CMNT \u0000 maternity department. \u0000Outcome: 34 patients records were analyzed. The average age of the patients was 32 years with extremes of 21 \u0000 and 44 years. The therapeutic option was a combination of acetyl salicylic acid and low molecular weight heparin. \u0000 The success rate of the treatment was 97% full-term pregnancies against 12% without treatment.","PeriodicalId":22164,"journal":{"name":"Surgery, gynecology & obstetrics","volume":"183 1","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2017-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74511085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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