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Side Effects of Hormonal Contraception of Patients in the Family Planning of Centre University Hospital of Mother and Child Lagoon, Cotonou (Benin) 贝宁科托努母婴湖中心大学医院计划生育患者激素避孕不良反应分析
Pub Date : 2017-09-26 DOI: 10.4172/2161-0932.1000452
T. Ja, M. Aboubakar, Tognifode, Lokossou M.S.H.S, O. Aaa, K. Salifou, E. Assogba, R. Perrin
Objective: To take a census of side effects related to the use of hormonal contraception reported by the women received in the Family Planning (FP) Service of CHU-MEL. Patients and methods: It was a cross-sectional prospective study which was carried out in the family planning service ofCHU-MEL in Cotonouover a three-month period from June 1st to August 31st, 2016. Results: 303 women were involved in this survey. The average age was 33 years (extremes of 15 and 49 years).Side effects were vaginal bleeding apart from the menses (37.2%) amenorrhea (32%) and weight increase (27.3%). The reasons for abandonment of hormonal contraceptionwere amenorrhea (13%), weight gain (11%), pelvic pain (0.07), nausea (0.05%) and bleeding (0.04). Conclusion: Hormonal contraception has many side effects. Some of them are well known by patients. They influence compliance with treatment. Their management is not always optimal and leads to abandonment.
目的:了解驻港卫生院计划生育服务所收治妇女使用激素类避孕药的不良反应情况。患者与方法:本研究为横断面前瞻性研究,于2016年6月1日至8月31日在科托努市医院计划生育服务中心开展。结果:303名女性参与了本次调查。平均年龄为33岁(极端为15岁和49岁)。不良反应为月经外阴道出血(37.2%)、闭经(32%)、体重增加(27.3%)。放弃激素避孕的原因为闭经(13%)、体重增加(11%)、盆腔疼痛(0.07%)、恶心(0.05%)和出血(0.04%)。结论:激素避孕有许多副作用。其中一些是病人熟知的。它们影响治疗的依从性。他们的管理并不总是最佳的,并导致放弃。
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引用次数: 2
Immunohistochemical Expression of Human Epididymis 4 (He4) in Ovarian Serous Carcinoma in Hospital Serdang from the Year 2006- 2013 2006- 2013年Serdang医院卵巢浆液性癌中人附睾4 (He4)的免疫组织化学表达
Pub Date : 2017-09-22 DOI: 10.4172/2161-0932.1000453
Frhana Rahmat, H. Ithnin
Ovarian cancer is the fifth most common cause of cancer death in women worldwide and is the fourth leading cause of cancer related deaths in Malaysia. Ovarian cancer are classified based on histological types, because it is an important surrogate for genetic, prognostic, and predictive information about response to treatment. The malignant epithelial tumor, that is ovarian carcinoma (OC) is the most common group and the four most common subtypes of OC are serous, endometrioid, clear cell and mucinous. Among the OC, ovarian serous carcinoma (OSC) is the most common subtypes. Most of the women with OC presented with locally advanced disease or distant metastasized at the time of diagnosis. The two-tier grading system (also known as MDACC [M.D Anderson Cancer Center] grading system) has been accepted worldwide. Human epididymis 4 (HE4) is a new protein which is frequently overexpressed in ovarian neoplastic tissue. Previous studies have shown that there is significant difference of HE4 expression in low grade serous carcinoma (LGSC) and high grade serous carcinoma (HGSC). The aim of this study is to further evaluate the HE4 tissue expression in 2 different grades of OSC in Hospital Serdang. This is a retrospective, cross-sectional study, of 71 cases histopathologically diagnosed as OSC comprising of 48 cases of HGSC and 23 cases of LGSC. Cases were collected from Hospital Serdang, from 1st January 2006 to 31st December 2013. All cases were examined for HE4 expression by immunohistochemistry using anti-HE4 (Polyclonal rabbit antibody dilution 1:40, Abcam).
卵巢癌是全世界妇女癌症死亡的第五大常见原因,也是马来西亚癌症相关死亡的第四大原因。卵巢癌是根据组织学类型进行分类的,因为它是遗传、预后和治疗反应预测信息的重要替代指标。恶性上皮肿瘤,即卵巢癌(OC)是最常见的一组,卵巢癌最常见的四种亚型是浆液性、子宫内膜样、透明细胞和黏液性。卵巢浆液性癌(OSC)是卵巢癌中最常见的亚型。大多数女性卵巢癌患者在诊断时表现为局部晚期或远处转移。两级分级制度(也称为MDACC) [M。D .安德森癌症中心的分级系统)已被全世界所接受。人附睾4蛋白(HE4)是卵巢肿瘤组织中经常过表达的一种新蛋白。既往研究表明HE4在低级别浆液性癌(LGSC)和高级别浆液性癌(HGSC)中表达有显著差异。本研究的目的是进一步评估Serdang医院2个不同级别OSC中HE4的组织表达。这是一项回顾性的横断面研究,对71例组织病理学诊断为OSC的病例进行了研究,其中包括48例HGSC和23例LGSC。病例于2006年1月1日至2013年12月31日在Serdang医院收集。采用抗HE4抗体(兔多克隆抗体稀释1:40,Abcam)免疫组化检测HE4表达。
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引用次数: 2
Three-Dimensional Angiogenic Evaluation of the Effect of Mifepristone in Early Gestation: Pilot Study 米非司酮在妊娠早期血管生成效果的三维评价:初步研究
Pub Date : 2017-09-20 DOI: 10.4172/2161-0932.1000451
B. Pellicer-Iborra, S. Herraiz, A. Morales, S. Martínez, N. Garrido, A. Pellicer
Mifepristone (RU486) it is known as an effective abortifacient and postcoital contraceptive method, whose mechanism is not yet known. We carried on a pilot study with the aim of determining the effect that Mifepristone could have in utero-placental vascular compartment during the first trimester of pregnancy compared with placebo. This is a randomized, double-blind, placebo-controlled research. We randomly assigned to two groups patients requesting pregnancy termination with a gestational age between 9th and 11st weeks: Group A receiving placebo and Group B receiving RU. With transvaginal ultrasound tridimensional probe we measured at an initial time (t1) and then 4 hours after administration of Mifepristone or placebo (t2) Doppler parameters: uterine arteries mean Resistance Index, spiral arteries Resistance Index, intervillous flow, umbilical Resistance Index and tridimensional vascular settings and the placental volume. We observed how Mifepristone shows an immediate selective hemodynamic effect in trophoblastic tissue in the first hours of administration. A significant decrease in spiral arteries pulsatility index was demonstrated, without modifying uterine maternal and fetal territories or the other studied parameters. Angiopower 3D evaluation of the interface maternal fetal is complex and encourages to carry further investigations carry further investigations.
米非司酮(RU486)是一种有效的人工流产和性交后避孕方法,其作用机制尚不清楚。我们进行了一项初步研究,目的是确定与安慰剂相比,米非司酮在妊娠前三个月对子宫-胎盘血管室的影响。这是一项随机、双盲、安慰剂对照的研究。我们将孕周在9周到11周之间要求终止妊娠的患者随机分为两组:a组接受安慰剂,B组接受RU。应用经阴道超声三维探头分别在初始时间(t1)和给予米非司酮或安慰剂后4小时(t2)测量多普勒参数:子宫动脉平均阻力指数、螺旋动脉阻力指数、绒毛间流量、脐带阻力指数、三维血管设置和胎盘体积。我们观察到米非司酮在给药的第一个小时内对滋养层组织有立即的选择性血流动力学影响。螺旋动脉搏动指数明显下降,没有改变子宫母体和胎儿领地或其他研究参数。angiopopower三维评价界面母胎是复杂的,鼓励进行进一步的调查进行进一步的调查。
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引用次数: 0
Invasive Cancer of the Vulva: Clinical and Therapeutic Aspects in the Gynecology and Obstetrics Service at Donka Hospital, Guinea- Conakry 外阴浸润性癌:几内亚科纳克里东卡医院妇产科服务的临床和治疗方面
Pub Date : 2017-09-04 DOI: 10.4172/2161-0932.1000450
Camara Mk, Williams Ld, K. Diarra, M. Mamoudou, B. Ousmane, K. Namory
It was a retrospective and descriptive study based on the calculation of the frequency, and to describe the clinical epidemiology, anatomopathologics and therapeutics aspects of the vulva cancers recorded between 1st of January 2005 to 31st of December 2014 at the service. We recorded 12 cases with Medium Age of 54 years, with extremity of 22 years and 84 years. We noted 1% of vulva cancer among the 1234 cases of Gynecological cancers diagnosed in the service. Two- third of the patients were elder than 55 years and the multiparous with 75%. The prurition and the tumefaction were the principal motive of consultation among 41.66 %. The tumor had epithelial origin in the clinical stage III in 50% of cases according to FIGO (2009). 3.6% of vulvectomy associated with lymphadenectomy in two-third and one case of radiotherapy. The cancers cases recorded were invasive epithelium type in old age women. These were intended to allow precocious diagnose and adequate taking care of the disease.
这是一项基于频率计算的回顾性描述性研究,描述了2005年1月1日至2014年12月31日在该服务中记录的外阴癌的临床流行病学,解剖病理学和治疗方面。我们记录了12例患者,其中年龄54岁,下肢22岁和84岁。我们注意到,在1234例妇科癌症确诊病例中,有1%为外阴癌。三分之二的患者年龄在55岁以上,75%的患者为多产。41.66%的患者咨询的主要动机是瘙痒和肿胀。根据FIGO(2009)的研究,50%的临床III期病例的肿瘤起源于上皮。3.6%的外阴切除术合并淋巴结切除术的三分之二和一例放疗。记录的癌症病例为浸润性上皮型老年妇女。这些都是为了提前诊断和充分照顾疾病。
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引用次数: 0
Pain Control of Medical Abortion with Misoprostol in the First Trimester of Pregnancy 米索前列醇对妊娠早期药物流产疼痛的控制
Pub Date : 2017-08-30 DOI: 10.4172/2161-0932.1000449
S. Mahboobeh, A. Fatemeh, S. Mamak, P. Reihaneh, S. Nafiseh
Background: Abortion is the most common subjects of obstetric which has applied two methods including surgical and medical approaches. Pain is the most common complication of medical abortion and pain relief is one the most important items in these patients. Objectives: Evaluated the effect of three non-steroidal anti-inflammatory drugs in pain reduction of medical abortion in less than 14 weeks gestation with forensics declaration. Methods: This study was a retrospective cohort in 66 pregnant women with less than 14 weeks gestation referred to Yas hospital for medical abortion that were assigned to three groups based on sedative drugs: A) Mefenamic acid capsules 250 mg, B) Diclofenac tablets 100 mg and C) Ibuprofen tablets 400 mg. The standardized visual assessment scale was assessed before and after drug administration that presented in medical records of patients. Results: Comparison of visual assessment scale means before and after using of three non-steroidal antiinflammatory drugs demonstrated that all three drugs lead to pain relief after the abortion that was significant statistically (P value=0.001). There was a significant difference in termination time of pregnancy between three groups, (P value= 0.016). In the case of hemoglobin drop, diclofenac lead to the lowest hemoglobin drop (P value=0.004). The amount of receiving narcotic among three groups revealed the significant difference (P value= 0.000). There were not significant differences in pain relief (P value=0.327) and demographic data between three groups. Conclusion: It was indicated that the three NSAIDs drugs, had a significant effect on the management of pain, diclofenac expended less termination time of pregnancy, narcotic drug usage and also hemoglobin drop than other groups. What does this study add? Non-steroidal anti-inflammatory drugs are effective in pain management of medical abortion and some of them are preferred to others. Diclofenac can reduce abortion time and also hemoglobin drop after abortion and additional dose of other narcotics too.
背景:流产是产科最常见的问题,已应用两种方法,包括手术和医疗途径。疼痛是药物流产最常见的并发症,缓解疼痛是药物流产患者最重要的项目之一。目的:评价三种非甾体类抗炎药对妊娠14周以下药物流产镇痛的疗效,并有法医鉴定。方法:采用回顾性队列研究方法,将66例妊娠小于14周的在雅斯医院进行药物流产的孕妇按镇静药物分为3组:甲非那酸胶囊250 mg,双氯芬酸片100 mg,布洛芬片400 mg。采用标准化视觉评定量表对患者用药前后的病历资料进行评定。结果:三种非甾体类抗炎药物使用前后的视觉评定量表均值比较显示,三种药物均能缓解流产后疼痛,差异有统计学意义(P值=0.001)。三组患者终止妊娠时间差异有统计学意义(P值= 0.016)。血红蛋白下降时,双氯芬酸导致的血红蛋白下降最低(P值=0.004)。三组间麻醉药物用量差异有统计学意义(P值= 0.000)。三组患者疼痛缓解程度及人口学资料差异无统计学意义(P值=0.327)。结论:三种非甾体抗炎药对疼痛的控制效果显著,双氯芬酸组妊娠终止时间短,麻醉药物使用少,血红蛋白下降明显低于其他组。这项研究补充了什么?非甾体类抗炎药在药物流产的疼痛管理中是有效的,其中一些药物比其他药物更受欢迎。双氯芬酸可缩短流产时间,减少流产后血红蛋白下降,并可增加其他麻醉剂的剂量。
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引用次数: 2
Efficacy of a New Compound Containing Cimicifuga Racemosa on Menopausal Symptoms in Women with Breast Cancer 含总状慈母新化合物对乳腺癌妇女绝经期症状的疗效观察
Pub Date : 2017-08-26 DOI: 10.4172/2161-0932.1000448
M. Stracquadanio, M. Giunta, A. D'Agati, C. Pafumi, L. Ciotta, M. Palumbo
The Hormone Replacement Therapy (HRT) is the "first-line therapy" for women with moderate / severe menopausal symptoms (hot flashes, profuse sweating, insomnia, osteoporosis). However, when the symptomatology is lighter or there are contraindications to HRT (breast disease, cardiovascular disease, thrombophilic diathesis, smoke, etc), woman can benefit from some preparations such as phytoestrogens and Cimicifuga racemosa. At present there are insufficient data regarding the efficacy and safety of phytoestrogens in women with breast cancer: because this tumour disease is hormone-dependent, phytoestrogens should be considered contraindicated in patients survived to the disease. Our study assessed both the effectiveness of a new compound containing Cimicifuga racemosa, Agnus-Castus, Ginger, Hyaluronic acid and Zinc on the neurovegetative menopausal symptoms (hot flashes, profuse sweating, insomnia) and its safe use in patients with breast cancer. The results have shown that this compound is an excellent alternative to estrogen treatment of menopausal neurovegetative symptoms, even for patients with breast cancer who cannot take HRT or phytoestrogens.
激素替代疗法(HRT)是有中度/重度更年期症状(潮热、多汗、失眠、骨质疏松)的妇女的“一线疗法”。然而,当症状较轻或有激素替代疗法的禁忌症(乳房疾病、心血管疾病、血栓性体质、吸烟等)时,妇女可以从一些制剂中获益,如植物雌激素和总状慈母。目前,关于植物雌激素对女性乳腺癌患者的疗效和安全性的数据不足:由于这种肿瘤疾病是激素依赖性的,因此应将植物雌激素视为生存到该疾病的患者的禁忌症。我们的研究评估了一种含有西洋参、牛蒡、生姜、透明质酸和锌的新化合物对绝经期神经植物性症状(潮热、大量出汗、失眠)的有效性及其在乳腺癌患者中的安全性。结果表明,这种化合物是雌激素治疗绝经期神经植物症状的极好替代品,甚至对不能服用激素替代疗法或植物雌激素的乳腺癌患者也是如此。
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引用次数: 0
HIPEC for peritoneal malignancies HIPEC用于腹膜恶性肿瘤
Pub Date : 2017-08-18 DOI: 10.4172/2161-0932-C1-014
A. Chevinsky
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引用次数: 1
Use of Magnesium Sulphate in the Management of Severe Preeclampsia at the Centre University Hospital of Mother and Child (CHU-MEL) Cotonou Benin 在贝宁科托努中心大学妇幼医院(CHU-MEL)使用硫酸镁治疗重度先兆子痫
Pub Date : 2017-08-18 DOI: 10.4172/2161-0932.1000447
T. Ja, Lokossou Mshs, F. Aboubakar, H. Bib, O. Aaa, K. Salifou, A. Lokossou, Perrin Rx
Objectives: To evaluate professionals practices and the contribution of magnesium sulphate in a better medical care for persons with severe preeclampsia at CHU-MEL. Materials and Method: We conducted a retrospective and cross-sectional study with the aim come up with a descriptive and analytical paper. Our study was conducted from January 15th, 2015 to July 15th, 2016, i.e. during eighteen (18) months. The sampling was exhaustive. The population was made of all patients admitted for severe preeclampsia with or without complications. Confidentiality requirements were met and informed consent obtained from all subjects. For the analytical study, the chi-square test was used and the difference was statistically significant with a p-value inferior than 0.05. Results: The prevalence of preeclampsia during the study period was 7.70% (447/5805 deliveries). Out of the 312 files that we were able to find and exploit, 272 revealed that patients were administrated a dose of magnesium sulphate, at a frequency estimated at 87.18%. Irregularities were noted in the protocol implementation: the maintenance dose was administered in 30% of cases, as a slow infusion (66.33%), for less than 24 hours in 37.24% of cases, and under supervision only in 22.62% of cases. Primary and secondary prevention of eclampsia was achieved in 98.5% and 80% of cases, respectively. Respecting the duration of treatment significantly reduces the onset and recurrence of seizures (p=0.003 and p=0.004). Decreased reflexes and respiratory distress were noted in 34.78% and in 8.7% of cases respectively. The maternal lethality rate was 1.34% and the stillbirth rate was 11.40%. Conclusion: Magnesium sulphate intake is undeniable in dealing with severe preeclampsia, but this solution/ drug is misused at the CHU-MEL. Appropriate solutions must therefore be taken in the execution and monitoring of the protocol.
目的:评价专业实践和硫酸镁在CHU-MEL重症子痫前期患者更好的医疗护理中的作用。材料和方法:我们进行了回顾性和横断面研究,目的是提出一个描述性和分析性的论文。我们的研究时间为2015年1月15日至2016年7月15日,共18个月。抽样是详尽的。该人群由所有伴有或不伴有并发症的严重子痫前期患者组成。遵守保密要求并获得所有受试者的知情同意。分析性研究采用卡方检验,p值小于0.05,差异有统计学意义。结果:研究期间子痫前期患病率为7.70%(447/5805例分娩)。在我们能够找到和利用的312份文件中,272份显示患者被给予硫酸镁剂量,频率估计为87.18%。方案实施中存在不规范之处:30%的病例给予维持剂量,66.33%的病例缓慢输液,37.24%的病例少于24小时,只有22.62%的病例在监督下。子痫的一级和二级预防分别达到98.5%和80%。尊重治疗时间可显著减少癫痫发作和复发(p=0.003和p=0.004)。反射下降和呼吸窘迫分别占34.78%和8.7%。产妇死亡率为1.34%,死产率为11.40%。结论:硫酸镁的摄入在治疗重度子痫前期是不可否认的,但这种溶液/药物在cho - mel被滥用。因此,在协议的执行和监控中必须采取适当的解决方案。
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引用次数: 1
Evaluation of Factors Affecting the Utilization of Partograph by Nurses/ Midwives in Primary/Secondary Health Facilities in Enugu Metropolis 影响埃努古市初级/二级卫生机构护士/助产士使用产程的因素评估
Pub Date : 2017-08-05 DOI: 10.4172/2161-0932.1000446
A. Nwaneri, Ndie Ec, I. Ehiemere, E. Okafor, E. Po, A. Emeh
This study aimed at evaluating factors that impede utilization and those that promote the utilization partograph by nurses/midwives in monitoring labour in primary/secondary health facilities in Enugu metropolis. Seven health facilities were selected using convenience sampling method. One hundred and twenty six nurses/midwives were used while self- structured questionnaire was used as instrument of data collection. The findings of this study revealed that majority of the nurses/ midwives face a lot of challenges in utilizing the partograph. Some of the major factors that impede the utilization include lack of knowledge of the partograph 68(54%) and inability to interpret findings correctly after assessment with the partograph (73.8%). The major factors that can promote the utilization of partograph include provision of necessary resources such as observation tools (83.3%) like sphygmomanometer, fetoscope and provision of partograph charts in the labour wards (69%). It was concluded that the major factors in the nurses/ midwives that impede the utilization of partograph includes lack of knowledge, inability to interpret findings correctly after assessment with the partograph and that partograph is an additional time consuming task for the inadequate staff. It is recommended that all nurses/ midwives should work towards self-development through education to increase knowledge and skill on partograph use. Management should stand up for their responsibility to encourage and sponsor seminars/workshops as well as conferences on partograph use for quality client care.
这项研究的目的是评估妨碍利用和促进利用的因素,护士/助产士在埃努古大都市的初级/中级卫生设施监测分娩。采用方便抽样法选取7家卫生机构。以126名护士/助产士为研究对象,采用自构式问卷作为数据收集工具。本研究结果显示,大多数护士/助产士在使用产程时面临许多挑战。一些阻碍使用的主要因素包括缺乏对第68段的了解(54%)和无法正确解释使用第68段评估后的结果(73.8%)。促进产程利用的主要因素包括提供必要的资源,如血压计、胎儿镜等观察工具(83.3%)和产程病房提供产程图(69%)。结论是,护士/助产士中阻碍剖宫产使用的主要因素包括缺乏知识,无法正确解释剖宫产评估后的结果,以及剖宫产对不足的工作人员来说是一项额外的耗时任务。建议所有护士/助产士都应该通过教育来提高产妇使用的知识和技能,从而努力实现自我发展。管理部门应该承担起鼓励和赞助研讨会/讲习班以及会议的责任,以提高客户服务的质量。
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引用次数: 6
Indication of caesarean section in the childbirth of a macrosome in a Level 2 Health Center in Dakar 达喀尔二级保健中心大新生儿剖宫产指征
Pub Date : 2017-07-28 DOI: 10.4172/2161-0932.1000445
M. Niang, Y. Gaye, A. Mbodj, M. Thiam, Cisse Ct
Objectives: To determine the factors influencing the mode of delivery in case of fetal macrosomia. Materials and Methods: That was a retrospective, descriptive and analytical study carried out from October 1st 2010 to March 31st 2013 at the maternity of Gaspard Kamara Health Center in Dakar. A multivariate analysis using logistic regression was used to determine the factors which influence the mode of delivery in case of fetal macrosomia. Results: We collected 333 delivery records of macrosome on 10639 registered births, a rate of 3.1%. Two hundred and fifteen (215) patients met the inclusion criteria. The labor’s test was performed in 55.3% of patients with a failure rate of 15.1%. Caesarean section was performed in 22.8% of patients. The main indications were: acute fetal distress (36.7%), the fetal-pelvic disproportion (26.5%), premature rupture of membranes (12.2%), the extended labor (10.2%), and the lack of engagement (10.2%). All newborns had Apgar score in the fifth minute greater than or equal to 7. The factors that influenced the type of delivery were: fetal weight above 4300 g (p=0.007), nulliparity (p<0.001) and a uterine height upper than 34 cm (p=0.034). Conclusion: In case of fetal macrosomia, fetal weight above 4300 g, nulliparity and the upper uterine height 34 cm are associated with a higher incidence of caesarean delivery.
目的:探讨影响巨大儿分娩方式的因素。材料和方法:这是一项回顾性、描述性和分析性研究,于2010年10月1日至2013年3月31日在达喀尔Gaspard Kamara健康中心的产科进行。采用logistic回归方法对影响巨大儿分娩方式的因素进行多因素分析。结果:在10639例新生儿中收集到巨体分娩记录333例,分娩率3.1%。215例患者符合纳入标准。产程检查成功率为55.3%,失败率为15.1%。22.8%的患者行剖腹产手术。主要指征为:急性胎儿窘迫(36.7%)、胎盆比例失调(26.5%)、胎膜早破(12.2%)、产程延长(10.2%)、未接合(10.2%)。所有新生儿的阿普加评分在第五分钟大于等于7分。影响分娩类型的因素为:胎重大于4300 g (p=0.007)、无产(p<0.001)和子宫高度大于34 cm (p=0.034)。结论:巨大儿、胎重4300 g以上、宫位及上宫高度34 cm与剖宫产发生率较高有关。
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引用次数: 0
期刊
Surgery, gynecology & obstetrics
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