In this study, it was aimed to production and characterization of paracetamol (PCT) loaded microcapsules and microcapsule added electro spun PVA nanofibers. Eudragit RS 100 and PVA were used as the shell in the microcapsule structure, and PCT was used as the core material. First of all, the PCT loaded Eudragit RS 100/PVA microcapsules were produced by solvent evaporation method under the optimum process parameters. Then, properties such as conductivity, viscosity and surface tension of the microcapsule loaded PVA solution were measured and the effects of microcapsule concentration on the solution properties were determined. According to the solution results, while the viscosity increased with the microcapsule concentration, conductivity and surface tension did not change significantly except for the PVA-10 sample. After the electrospinning process, fibre morphology was determined by SEM and incorporation of microcapsules into the nanofibers was clearly demonstrated. It was calculated from the SEM images that average microcapsule size is 9.81μm, average fibre diameter is 550 nm and fibre diameter uniformity coefficient is 1.025. Finally, the incorporation of PCT loaded microcapsules into the nanofibers was chemically confirmed by FT-IR analysis. It is thought that the results of this study will be useful for controlled drug release, especially in medical textiles.
{"title":"PARACETAMOL DRUG LOADED MICROCAPSULE BASED\u0000NANOFIBER PRODUCTION","authors":"İ.Y. Mol, F. C. Çallıoğlu, H. Güler, M. Geysoğlu","doi":"10.35530/tt.2021.30","DOIUrl":"https://doi.org/10.35530/tt.2021.30","url":null,"abstract":"In this study, it was aimed to production and characterization of paracetamol (PCT) loaded\u0000microcapsules and microcapsule added electro spun PVA nanofibers. Eudragit RS 100 and PVA were used as\u0000the shell in the microcapsule structure, and PCT was used as the core material. First of all, the PCT loaded\u0000Eudragit RS 100/PVA microcapsules were produced by solvent evaporation method under the optimum process\u0000parameters. Then, properties such as conductivity, viscosity and surface tension of the microcapsule loaded PVA\u0000solution were measured and the effects of microcapsule concentration on the solution properties were\u0000determined. According to the solution results, while the viscosity increased with the microcapsule concentration,\u0000conductivity and surface tension did not change significantly except for the PVA-10 sample. After the\u0000electrospinning process, fibre morphology was determined by SEM and incorporation of microcapsules into the\u0000nanofibers was clearly demonstrated. It was calculated from the SEM images that average microcapsule size is\u00009.81μm, average fibre diameter is 550 nm and fibre diameter uniformity coefficient is 1.025. Finally, the\u0000incorporation of PCT loaded microcapsules into the nanofibers was chemically confirmed by FT-IR analysis. It\u0000is thought that the results of this study will be useful for controlled drug release, especially in medical textiles.","PeriodicalId":22214,"journal":{"name":"TEXTEH Proceedings","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2021-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85745199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}