{"title":"Social security net for the mentally ill","authors":"Lian-Yu Chen","doi":"10.4103/tpsy.tpsy_11_23","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_11_23","url":null,"abstract":"","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74485638","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
S. Datta, S. Roy, Nitu Mallik, I. Saha, AsimKr Mallick
Objective: Burnout is a state of physical and emotional depletion, and it is a result of prolonged exposure to the stressful working environment. Burnout has three primary symptoms: (a) emotional exhaustion (EE) occurs due to a depletion of emotional resources, feeling no longer to give any more to their job; (b) depersonalization (DP) occurs in response to EE, making employees detached from their job and developing uncaring attitudes to their work; and (c) reduced personal accomplishment (PA) with perceiving less enjoyment from their work. Psychological distress is also higher among medical students and doctors than that in the general population. In this study, we intended to study the prevalence of burnout and various psychological problems among postgraduate trainee (PGT) doctors of a tertiary care hospital. Methods: In this cross-sectional study of one year, we recruited postgraduate training doctors whoever gave valid and informed consent. Results: We included 170 PGTs from various clinical departments at the time of our study, but 126 PGTs were included as the sample population. They were assessed for sociodemographic determinants first. Then received assessment using sociodemographic pro forma and Abbreviated Maslach Burnout Inventory and International Classification of Diseases 10 for screening psychiatric morbidity among them. Results: In this study, 31.7% of PGTs had high EE, 34.9% of them higher DP, and 30.2% of them a high burnout rate. Of them, 31.7% of PGTs had a reduced PA with a score ≤ 25 percentile. In this study, 83.3% had no psychiatric illness and 16.7% had a psychiatric disorder. Among psychiatric disorders, 4% had harmful use of tobacco, 4% had mild depression, 1.6% had panic disorder, 4.8% had mixed anxiety depression, 1.6% had obsessive-compulsive disorder, 0.8% had harmful use of alcohol. Highest EE was noted among PGTs from the Department of Anesthesiology, followed by those from the Departments of Pulmonary Medicine and then Radiotherapy. Conclusion: One-third of PGTs suffered from burnout. Psychiatric diseases were also increased with a higher burnout rate.
{"title":"Prevalence of burnout and psychiatric illness among postgraduate trainee doctors of a tertiary care hospital","authors":"S. Datta, S. Roy, Nitu Mallik, I. Saha, AsimKr Mallick","doi":"10.4103/tpsy.tpsy_36_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_36_22","url":null,"abstract":"Objective: Burnout is a state of physical and emotional depletion, and it is a result of prolonged exposure to the stressful working environment. Burnout has three primary symptoms: (a) emotional exhaustion (EE) occurs due to a depletion of emotional resources, feeling no longer to give any more to their job; (b) depersonalization (DP) occurs in response to EE, making employees detached from their job and developing uncaring attitudes to their work; and (c) reduced personal accomplishment (PA) with perceiving less enjoyment from their work. Psychological distress is also higher among medical students and doctors than that in the general population. In this study, we intended to study the prevalence of burnout and various psychological problems among postgraduate trainee (PGT) doctors of a tertiary care hospital. Methods: In this cross-sectional study of one year, we recruited postgraduate training doctors whoever gave valid and informed consent. Results: We included 170 PGTs from various clinical departments at the time of our study, but 126 PGTs were included as the sample population. They were assessed for sociodemographic determinants first. Then received assessment using sociodemographic pro forma and Abbreviated Maslach Burnout Inventory and International Classification of Diseases 10 for screening psychiatric morbidity among them. Results: In this study, 31.7% of PGTs had high EE, 34.9% of them higher DP, and 30.2% of them a high burnout rate. Of them, 31.7% of PGTs had a reduced PA with a score ≤ 25 percentile. In this study, 83.3% had no psychiatric illness and 16.7% had a psychiatric disorder. Among psychiatric disorders, 4% had harmful use of tobacco, 4% had mild depression, 1.6% had panic disorder, 4.8% had mixed anxiety depression, 1.6% had obsessive-compulsive disorder, 0.8% had harmful use of alcohol. Highest EE was noted among PGTs from the Department of Anesthesiology, followed by those from the Departments of Pulmonary Medicine and then Radiotherapy. Conclusion: One-third of PGTs suffered from burnout. Psychiatric diseases were also increased with a higher burnout rate.","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87904791","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: In a previous review article in the Taiwanese Journal of Psychiatry (Takeda and Tagami: Taiwanese J. Psychiatry 2020; 34: 152-61), we gave the development status of drugs for Alzheimer's disease, presented a relatively pessimistic view, and highlighted the difficulties in their development. Methods: Since I have witnessed some encouraging development of monoclonal antibody therapeutics against Alzheimer's disease, I have decided to contribute this article. I reviewed new data from published journals and from internal reports of pharmaceutical companies. I have also offered some explanations and comments. Results: In 2021, I saw promising clinical trial results reporting the use of aducanumab, a monoclonal antibody treatment against amyloid β protein, and the U.S. Food and Drug Administration (FDA) announced a decision for expedited approval of aducanumab. But the results of aducanumab's phase III clinical trials were considered by some to be insufficient for the approval, and the FDA's decision was controversial. The European and Japanese regulatory authorities did not approve aducanumab. In September 2022, however, more promising results were announced from Phase III clinical trials of another monoclonal antibody, lecanemab. Conclusion: In this review, I have recounted the state of the arts of drugs for treating dementia and highlighted remarkable recent progress in the development of monoclonal antibody therapeutics for Alzheimer's disease.
背景:台湾精神病学杂志先前的一篇综述文章(Takeda and Tagami: taiwan J. Psychiatry 2020;(34: 152-61)，我们给出了阿尔茨海默病药物的发展现状，提出了相对悲观的看法，并强调了其发展的困难。方法:由于我目睹了针对阿尔茨海默病的单克隆抗体治疗的一些令人鼓舞的发展，我决定贡献这篇文章。我从已发表的期刊和制药公司的内部报告中查阅了新的数据。我也做了一些解释和评论。结果:在2021年，我看到了有希望的临床试验结果，报告了aducanumab的使用，这是一种针对淀粉样蛋白β蛋白的单克隆抗体治疗，美国食品和药物管理局(FDA)宣布了加速批准aducanumab的决定。但一些人认为aducanumab的III期临床试验结果不足以获得批准，FDA的决定也引起了争议。欧洲和日本监管机构未批准aducanumab。然而，在2022年9月，另一种单克隆抗体lecanemab的III期临床试验公布了更有希望的结果。结论:在这篇综述中，我叙述了治疗痴呆症的药物的艺术状态，并强调了阿尔茨海默病单克隆抗体治疗的显着进展。
{"title":"Development of monoclonal antibody therapeutics for alzheimer's disease","authors":"M. Takeda","doi":"10.4103/tpsy.tpsy_31_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_31_22","url":null,"abstract":"Background: In a previous review article in the Taiwanese Journal of Psychiatry (Takeda and Tagami: Taiwanese J. Psychiatry 2020; 34: 152-61), we gave the development status of drugs for Alzheimer's disease, presented a relatively pessimistic view, and highlighted the difficulties in their development. Methods: Since I have witnessed some encouraging development of monoclonal antibody therapeutics against Alzheimer's disease, I have decided to contribute this article. I reviewed new data from published journals and from internal reports of pharmaceutical companies. I have also offered some explanations and comments. Results: In 2021, I saw promising clinical trial results reporting the use of aducanumab, a monoclonal antibody treatment against amyloid β protein, and the U.S. Food and Drug Administration (FDA) announced a decision for expedited approval of aducanumab. But the results of aducanumab's phase III clinical trials were considered by some to be insufficient for the approval, and the FDA's decision was controversial. The European and Japanese regulatory authorities did not approve aducanumab. In September 2022, however, more promising results were announced from Phase III clinical trials of another monoclonal antibody, lecanemab. Conclusion: In this review, I have recounted the state of the arts of drugs for treating dementia and highlighted remarkable recent progress in the development of monoclonal antibody therapeutics for Alzheimer's disease.","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80582656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objective: Depression can be a psychological reaction of a patient toward the diagnosis of neurocognitive disorder, and it can be a part of the complex biological response involving both illnesses. Both depression and neurocognitive disorders can cause low quality of life (QoL), especially in the elderly population. In this present study, we intended to assess the association of depression and the QoL among patients suffering from mild to major neurocognitive disorder at a tertiary hospital. Methods: This observational study was carried out at the department of psychiatry in a tertiary care hospital, among 100 patients, whose diagnosis was made according to DSM-5 criteria for mild to major neurocognitive disorder. Patients were administered semi-structured pro forma for collection of sociodemographic data, Addenbrooke'sCognitive Examination III R, Mini-Mental State Examination (MMSE) to assess the severity of mild and major neurocognitive disorders, Cornell Scale for Depression in Dementia was administered to assess the depression, World Health Organization (WHO) QoL-BREF Scale to assess the QoL among patients with mild to major neurocognitive disorders. Results: The mean age ± standard deviation of the study population was 70.31 ± 6.9 years. The sum of 43.3% of the study population belonged to the category of mild cognitive impairment, 46.7% the moderate, and 10% the severe type of cognitive impairment. The sum of 29.2% of the study population had depressive episodes, and 6.7% of the study population belonged to the category of definite major depression. Domain 2 of WHO QoL-BREF was maximum affected by mild and major neurocognitive disorders (p < 0.001). Conclusion: This study found that majority of the patients with neurocognitive disorders was affected by higher levels of depressive scores with a remarkable decrease in their QoL. Compared to neurodegenerative disorders, depression is much easily been effectively treated, this study stresses the importance of the aggressive diagnosis and treatment for depression for all patients with neurocognitive disorder.
目的:抑郁可能是患者对神经认知障碍诊断的一种心理反应，也可能是涉及两种疾病的复杂生物反应的一部分。抑郁症和神经认知障碍都可能导致低生活质量(QoL)，特别是在老年人中。在本研究中，我们旨在评估三级医院轻度至重度神经认知障碍患者抑郁与生活质量的关系。方法:本观察性研究在某三级医院精神科进行，纳入100例患者，根据DSM-5轻度至重度神经认知障碍标准进行诊断。采用半结构化问卷收集社会人口学数据，采用Addenbrooke'sCognitive Examination III R、Mini-Mental State Examination (MMSE)评估轻、重度神经认知障碍的严重程度，采用Cornell痴呆抑郁量表评估抑郁，采用WHO QoL- bref量表评估轻、重度神经认知障碍患者的生活质量。结果:研究人群的平均年龄±标准差为70.31±6.9岁。轻度认知障碍占研究人群的43.3%，中度认知障碍占46.7%，重度认知障碍占10%。29.2%的研究人群有抑郁发作，6.7%的研究人群属于明确的重度抑郁症。轻度和重度神经认知障碍对WHO QoL-BREF的Domain 2影响最大(p < 0.001)。结论:本研究发现，大多数神经认知障碍患者抑郁得分较高，生活质量明显下降。与神经退行性疾病相比，抑郁症更容易得到有效的治疗，本研究强调积极诊断和治疗抑郁症对所有神经认知障碍患者的重要性。
{"title":"The association of depression and quality of life in patients with neurocognitive disorder in a tertiary care center: An observational study","authors":"A. Endreddy, Lakshmi Chennareddy, V. Harshitha","doi":"10.4103/tpsy.tpsy_34_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_34_22","url":null,"abstract":"Objective: Depression can be a psychological reaction of a patient toward the diagnosis of neurocognitive disorder, and it can be a part of the complex biological response involving both illnesses. Both depression and neurocognitive disorders can cause low quality of life (QoL), especially in the elderly population. In this present study, we intended to assess the association of depression and the QoL among patients suffering from mild to major neurocognitive disorder at a tertiary hospital. Methods: This observational study was carried out at the department of psychiatry in a tertiary care hospital, among 100 patients, whose diagnosis was made according to DSM-5 criteria for mild to major neurocognitive disorder. Patients were administered semi-structured pro forma for collection of sociodemographic data, Addenbrooke'sCognitive Examination III R, Mini-Mental State Examination (MMSE) to assess the severity of mild and major neurocognitive disorders, Cornell Scale for Depression in Dementia was administered to assess the depression, World Health Organization (WHO) QoL-BREF Scale to assess the QoL among patients with mild to major neurocognitive disorders. Results: The mean age ± standard deviation of the study population was 70.31 ± 6.9 years. The sum of 43.3% of the study population belonged to the category of mild cognitive impairment, 46.7% the moderate, and 10% the severe type of cognitive impairment. The sum of 29.2% of the study population had depressive episodes, and 6.7% of the study population belonged to the category of definite major depression. Domain 2 of WHO QoL-BREF was maximum affected by mild and major neurocognitive disorders (p < 0.001). Conclusion: This study found that majority of the patients with neurocognitive disorders was affected by higher levels of depressive scores with a remarkable decrease in their QoL. Compared to neurodegenerative disorders, depression is much easily been effectively treated, this study stresses the importance of the aggressive diagnosis and treatment for depression for all patients with neurocognitive disorder.","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91146800","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Short-term naltrexone use associated with delayed-onset fever and hepatotoxicity: A case report","authors":"Chao- Hsu, Yu-Pei Ku, Hong Chen","doi":"10.4103/tpsy.tpsy_33_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_33_22","url":null,"abstract":"","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78203517","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Neutropenia following electroconvulsive therapy: A case report","authors":"Jhen-Gang Lai, Yang Bai","doi":"10.4103/tpsy.tpsy_35_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_35_22","url":null,"abstract":"","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73333410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Objectives: According to the most recent studies on the mental health impacts of coronavirus disease 2019 (COVID-19), psychological effects are salient in the community, but they are not obvious in the military population. In the study, we intended to examine mental health state and suicide ideation among soldiers with past histories of COVID-19 and to compare them with non-infected controls. Methods: We recruited 193 active-duty military personnel from northern Taiwan and collected their responses of a series of copies of the questionnaire, i.e., Beck's Depression Inventory for depression, Beck's Anxiety Inventory for anxiety, Davidson Trauma Scale for symptoms of posttramatic stress disorder (PTSD), Pittsburgh Sleep Quality Index for sleep disturbance and sleep dissatisfaction, and Five-item Brief Symptom Rating Scale for suicide ideation. Results: Among our samples, about 58.5% (113/193) reported a past history of COVID-19 infection (infected group) at least once. More than 85% had vaccinated in more than two doses. The infected soldier group presented themselves significantly higher magnitude (1.92 ± 0.54) of impacts on their lives than noninfected control group (1.72 ± 0.66, p < 0.05). The discrepancy in life impact between infected and non-infected groups was significantly more salient in male soldiers (p < 0.05) comparing with female. In male soldiers, most mental health states were higher in the non-infected group than the infected group but nonsignificant. Conclusion: This study shows the common and differences in mental health states and suicide ideation between COVID-19 infected and non-infected soldiers in Taiwan and genders. In line with the findings of current studies, our results showed nonsignificant differences between male and female groups in the military population although significant differences among the community population. Further studies with larger sample sizes and more details are needed to confirm our assumption.
{"title":"Mental health states of soldiers with histories of corona virus disease 2019 infection in Taiwan: A comparison study with non-infected soldiers","authors":"Hao-Ming Yang, Y. Tai, Szu-Tung Yang","doi":"10.4103/tpsy.tpsy_38_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_38_22","url":null,"abstract":"Objectives: According to the most recent studies on the mental health impacts of coronavirus disease 2019 (COVID-19), psychological effects are salient in the community, but they are not obvious in the military population. In the study, we intended to examine mental health state and suicide ideation among soldiers with past histories of COVID-19 and to compare them with non-infected controls. Methods: We recruited 193 active-duty military personnel from northern Taiwan and collected their responses of a series of copies of the questionnaire, i.e., Beck's Depression Inventory for depression, Beck's Anxiety Inventory for anxiety, Davidson Trauma Scale for symptoms of posttramatic stress disorder (PTSD), Pittsburgh Sleep Quality Index for sleep disturbance and sleep dissatisfaction, and Five-item Brief Symptom Rating Scale for suicide ideation. Results: Among our samples, about 58.5% (113/193) reported a past history of COVID-19 infection (infected group) at least once. More than 85% had vaccinated in more than two doses. The infected soldier group presented themselves significantly higher magnitude (1.92 ± 0.54) of impacts on their lives than noninfected control group (1.72 ± 0.66, p < 0.05). The discrepancy in life impact between infected and non-infected groups was significantly more salient in male soldiers (p < 0.05) comparing with female. In male soldiers, most mental health states were higher in the non-infected group than the infected group but nonsignificant. Conclusion: This study shows the common and differences in mental health states and suicide ideation between COVID-19 infected and non-infected soldiers in Taiwan and genders. In line with the findings of current studies, our results showed nonsignificant differences between male and female groups in the military population although significant differences among the community population. Further studies with larger sample sizes and more details are needed to confirm our assumption.","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81737628","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pei-Lun Chung, Shu-Hao Wu, Hong Chen, V. Chen, Min-Jing Lee
Objective: Lung cancer is the most common cancer and the leading cause of cancer death worldwide. Research on the correlation between posttraumatic stress symptoms (PTSSs) and lung cancer is limited. In this study, we intended to study PTSS predictors in patients with lung cancer and their subgroups. Methods: Patients aged ≥ 20 years with lung cancer diagnosis were recruited. We collected information on demographic characteristics, depressive symptoms, and cognitive function, to examine the effect on PTSSs. With the Chinese version of the startle, physiological arousal, anger, and numbness questionnaire, we analyzed the variables to identify the independent correlates of PTSSs and to compare differences among treatment and cancer stage subgroups. Results: A total of 329 lung cancer patients were included with prominent male, below senior high school education level, married status, unemployment, smoking history, non-alcohol drinker, without psychiatric history and comorbid diabetes and hypertension. The correlates of PTSSs were significantly higher in education level (β = 0.197, p < 0.01), cognitive function (β = −0.269, p < 0.001), and depressive symptoms (β = 0.294, p < 0.001). In subgroup analysis, high education level was significantly correlated of PTSSs in different treatment groups surgery group (β = 0.266, p < 0.05), nonsurgery group (β = 0.204, p < 0.05), chemotherapy group (β = 0.189, p < 0.05), and nonchemotherapy group (β = 0.220, p < 0.05). Cognitive function was significantly correlated of PTSSs in different cancer stages in early stage (β = −0.401, p < 0.01) and advanced stage (β = −0.182, p < 0.05). Conclusion: Depressive symptoms, high education level, and the poor cognitive function were significantly associated with PTSSs in patients with lung cancer. Health professionals in oncology should consider psychological burden screening, cognitive function examination, and rehabilitation in clinical practice.
目的:肺癌是世界上最常见的癌症，也是癌症死亡的主要原因。创伤后应激症状(ptsd)与肺癌的相关性研究有限。在这项研究中，我们打算研究肺癌患者及其亚组的PTSS预测因素。方法:招募年龄≥20岁、诊断为肺癌的患者。我们收集了人口学特征、抑郁症状和认知功能方面的信息，以检验ptsd的影响。采用中文版惊吓、生理唤醒、愤怒和麻木问卷，对各变量进行分析，以确定ptsd的独立相关因素，并比较治疗组和癌症分期亚组之间的差异。结果:共纳入329例肺癌患者，男性突出，高中以下文化程度，已婚，无业，有吸烟史，无饮酒史，无精神病史，无糖尿病和高血压合并症。ptsd在受教育程度(β = 0.197, p < 0.01)、认知功能(β = - 0.269, p < 0.001)和抑郁症状(β = 0.294, p < 0.001)上的相关系数显著高于ptsd。亚组分析显示，不同治疗组中，高文化程度与PTSSs有显著相关，手术组(β = 0.266, p < 0.05)、非手术组(β = 0.204, p < 0.05)、化疗组(β = 0.189, p < 0.05)、非化疗组(β = 0.220, p < 0.05)。认知功能与PTSSs在癌症早期(β = - 0.401, p < 0.01)和晚期(β = - 0.182, p < 0.05)有显著相关。结论:肺癌患者的抑郁症状、文化程度高、认知功能差与ptsd有显著相关。在临床实践中，肿瘤学卫生专业人员应考虑心理负担筛查、认知功能检查和康复。
{"title":"Lung cancer and posttraumatic stress symptoms: Predictive factors and subgroup analysis","authors":"Pei-Lun Chung, Shu-Hao Wu, Hong Chen, V. Chen, Min-Jing Lee","doi":"10.4103/tpsy.tpsy_32_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_32_22","url":null,"abstract":"Objective: Lung cancer is the most common cancer and the leading cause of cancer death worldwide. Research on the correlation between posttraumatic stress symptoms (PTSSs) and lung cancer is limited. In this study, we intended to study PTSS predictors in patients with lung cancer and their subgroups. Methods: Patients aged ≥ 20 years with lung cancer diagnosis were recruited. We collected information on demographic characteristics, depressive symptoms, and cognitive function, to examine the effect on PTSSs. With the Chinese version of the startle, physiological arousal, anger, and numbness questionnaire, we analyzed the variables to identify the independent correlates of PTSSs and to compare differences among treatment and cancer stage subgroups. Results: A total of 329 lung cancer patients were included with prominent male, below senior high school education level, married status, unemployment, smoking history, non-alcohol drinker, without psychiatric history and comorbid diabetes and hypertension. The correlates of PTSSs were significantly higher in education level (β = 0.197, p < 0.01), cognitive function (β = −0.269, p < 0.001), and depressive symptoms (β = 0.294, p < 0.001). In subgroup analysis, high education level was significantly correlated of PTSSs in different treatment groups surgery group (β = 0.266, p < 0.05), nonsurgery group (β = 0.204, p < 0.05), chemotherapy group (β = 0.189, p < 0.05), and nonchemotherapy group (β = 0.220, p < 0.05). Cognitive function was significantly correlated of PTSSs in different cancer stages in early stage (β = −0.401, p < 0.01) and advanced stage (β = −0.182, p < 0.05). Conclusion: Depressive symptoms, high education level, and the poor cognitive function were significantly associated with PTSSs in patients with lung cancer. Health professionals in oncology should consider psychological burden screening, cognitive function examination, and rehabilitation in clinical practice.","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83481891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: A recent study has shown the beneficial effects of interferon (IFN)-based antiviral therapy (AVT) in reducing the risk of newly diagnosed depression among patients with hepatitis C virus (HCV) infection. But whether IFN-based AVT reduces the risk of bipolar disorder remains unknown. Methods: This is a retrospective study based on the Taiwan National Health Insurance Research Database. From enrollment to the end of 2013, 24,240 patients with HCV infection (4473 treated with IFN-based AVT and 19,767 without such treatment) as well as 96,960 age- and sex-matched controls were included in this study. Time-dependent Cox regression models were used to study the differences in risk of newly-diagnosed bipolar disorder between patients being treated with and without IFN-based AVT and the control participants. Results: Patients with HCV infection who had not yet received IFN-based AVT (hazard ratio = 4.86, 95% confidence interval = 1.87–12.66, p = 0.001), but not those who were receiving IFN-based AVT (1.69, 0.94 - 30.50, nonsignificance) and those who completed the IFN-based AVT (1.77, 0.69 - 4.54, nonsignificance), were significantly more to be diagnosed with bipolar disorder compared with the control group. Conclusion: Our study supports the temporal association between HCV infection and subsequent bipolar disorder, further suggesting that the optimal AVT to eradicate HCV may be associated with a reduced risk of incident bipolar disorder later in life.
{"title":"Protective effect of interferon-based antiviral therapy on risk of bipolar disorder in patients with hepatitis C Virus infection: A nationwide longitudinal study","authors":"Mu-Hong Chen, S. Tsai, Tzeng-Ji Chen","doi":"10.4103/tpsy.tpsy_37_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_37_22","url":null,"abstract":"Background: A recent study has shown the beneficial effects of interferon (IFN)-based antiviral therapy (AVT) in reducing the risk of newly diagnosed depression among patients with hepatitis C virus (HCV) infection. But whether IFN-based AVT reduces the risk of bipolar disorder remains unknown. Methods: This is a retrospective study based on the Taiwan National Health Insurance Research Database. From enrollment to the end of 2013, 24,240 patients with HCV infection (4473 treated with IFN-based AVT and 19,767 without such treatment) as well as 96,960 age- and sex-matched controls were included in this study. Time-dependent Cox regression models were used to study the differences in risk of newly-diagnosed bipolar disorder between patients being treated with and without IFN-based AVT and the control participants. Results: Patients with HCV infection who had not yet received IFN-based AVT (hazard ratio = 4.86, 95% confidence interval = 1.87–12.66, p = 0.001), but not those who were receiving IFN-based AVT (1.69, 0.94 - 30.50, nonsignificance) and those who completed the IFN-based AVT (1.77, 0.69 - 4.54, nonsignificance), were significantly more to be diagnosed with bipolar disorder compared with the control group. Conclusion: Our study supports the temporal association between HCV infection and subsequent bipolar disorder, further suggesting that the optimal AVT to eradicate HCV may be associated with a reduced risk of incident bipolar disorder later in life.","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88123773","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Enhancing efficacy and acceptance of cognitive behavioral therapy through understanding its neuroscience","authors":"Susmita Halder, A. Mahato","doi":"10.4103/tpsy.tpsy_30_22","DOIUrl":"https://doi.org/10.4103/tpsy.tpsy_30_22","url":null,"abstract":"","PeriodicalId":22278,"journal":{"name":"Taiwanese Journal of Psychiatry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2022-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80605232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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