F. Irijanto, Herjanti Rahajeng, Sutarso Kamajaya, Mochammad Sja’bani, A. Sadewa, Y. Shimizu, Y. Tomino
Family studies demonstrated the contribution of genetic factor to the development of essential hypertension. While the familial component of blood pressure(BP) is well described, the risk of hypertension developing as a result of family history has not been well quantified . The heritage portion of blood pressure is estimated to range between 35% and 65% . Genetic polymorphisms are related to hypertension. Genes coded in the components of renin-angiotensin-aldosteron system(RAAS) are crucial in the pathogenesis of essensial hypertension via the blood pressure management. Epidemiological studies have suggested that nucleotide sequence variations of genes such as angiotensinogen(AGT), renin(REN), angiotensin-converting enzyme (ACE), angiotensin II receptor type I(AT─1R) and aldosterone synthase(CYP11B2) are associated with the risk of essensial hypertension . The ACE insertion/deletion(I/D) gene polymorphism and a predisposition to hypertension have been shown in many studies. More than 100 polyOriginal Articles
{"title":"High D Allele Frequency of ACE I/D Gene Polymorphism in Familial Hypertension in Javanese Indonesian","authors":"F. Irijanto, Herjanti Rahajeng, Sutarso Kamajaya, Mochammad Sja’bani, A. Sadewa, Y. Shimizu, Y. Tomino","doi":"10.14789/PJMJ.58.224","DOIUrl":"https://doi.org/10.14789/PJMJ.58.224","url":null,"abstract":"Family studies demonstrated the contribution of genetic factor to the development of essential hypertension. While the familial component of blood pressure(BP) is well described, the risk of hypertension developing as a result of family history has not been well quantified . The heritage portion of blood pressure is estimated to range between 35% and 65% . Genetic polymorphisms are related to hypertension. Genes coded in the components of renin-angiotensin-aldosteron system(RAAS) are crucial in the pathogenesis of essensial hypertension via the blood pressure management. Epidemiological studies have suggested that nucleotide sequence variations of genes such as angiotensinogen(AGT), renin(REN), angiotensin-converting enzyme (ACE), angiotensin II receptor type I(AT─1R) and aldosterone synthase(CYP11B2) are associated with the risk of essensial hypertension . The ACE insertion/deletion(I/D) gene polymorphism and a predisposition to hypertension have been shown in many studies. More than 100 polyOriginal Articles","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"62 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116597576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Evaluation of Anti-p53 Antibodies as a Molecular Marker for Breast Carcinoma","authors":"K. Sugiyama, M. Fukunaga, M. Suda","doi":"10.14789/PJMJ.58.173","DOIUrl":"https://doi.org/10.14789/PJMJ.58.173","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"321 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123252059","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Ikejima, Y. Suga, Y. Mizuno, K. Haruna, K. Taneda, Kazuhiro Kourou, Toshiaki Shimizu, Takashi Yosiike, H. Ogawa, S. Ikeda
Objective ：Inherited keratinizing disorders are a spectrum of relatively rare skin diseases with a variety of congenital defects in the keratinizing process. In this study, we evaluated patients with inherited keratinizing disorders in the Tokyo urban area from the clinicians’ viewpoint. retrospectively evaluated 77 cases of inherited keratinizing disorders（male ／ 34 cases, mean age at first visit：20.2 years） who visited our institution in the past 5 years. into 3 major groups; ichthyoses, palmoplantar keratodermas（PPK）, and macular- and punctuate-type keratodermas. Definite diagnoses were achieved according to the clinico-pathological features and genetic analyses. Results ：The ichthyoses group（48 cases：62.3%） consisted of dominant ichthyosis vulgaris（IV：13 cases）, X-linked ichthyo-sis（XLI：16 cases）, lamellar ichthyosis（LI：4 cases）, and bullous ／ nonbullous congenital ichthyosiform erythroderma（BCIE and NBCIE：3 cases each）. PPK groups（21 cases：27.3%） included Vörner-type（7 cases） and Nagashima-type（9 cases）. Macular ／ punctuate-type keratodermas（8 cases：10.4%） included 4 cases of Darier’s disease. The discrepancy between percentages above and reported incidence of each disorder most likely resulted from the increasing tendency of visits in patients with severe symptoms. The therapeutic approach was application of topical moisturizers, in combination with topical vitamin D3 analogue, steroid, and antibiotics ／ antifungal agents. In addition, some cases were treated with oral retinoids and antihistamines. genetic analysis necessary for diagnosis, this simplified classification based on clinical and changes seems to be useful for and The establishment guidelines in Japan is urgently
{"title":"Clinical Manifestation and Classification of Japanese patients with Inherited Keratinizing Disorders","authors":"A. Ikejima, Y. Suga, Y. Mizuno, K. Haruna, K. Taneda, Kazuhiro Kourou, Toshiaki Shimizu, Takashi Yosiike, H. Ogawa, S. Ikeda","doi":"10.14789/PJMJ.58.135","DOIUrl":"https://doi.org/10.14789/PJMJ.58.135","url":null,"abstract":"Objective ：Inherited keratinizing disorders are a spectrum of relatively rare skin diseases with a variety of congenital defects in the keratinizing process. In this study, we evaluated patients with inherited keratinizing disorders in the Tokyo urban area from the clinicians’ viewpoint. retrospectively evaluated 77 cases of inherited keratinizing disorders（male ／ 34 cases, mean age at first visit：20.2 years） who visited our institution in the past 5 years. into 3 major groups; ichthyoses, palmoplantar keratodermas（PPK）, and macular- and punctuate-type keratodermas. Definite diagnoses were achieved according to the clinico-pathological features and genetic analyses. Results ：The ichthyoses group（48 cases：62.3%） consisted of dominant ichthyosis vulgaris（IV：13 cases）, X-linked ichthyo-sis（XLI：16 cases）, lamellar ichthyosis（LI：4 cases）, and bullous ／ nonbullous congenital ichthyosiform erythroderma（BCIE and NBCIE：3 cases each）. PPK groups（21 cases：27.3%） included Vörner-type（7 cases） and Nagashima-type（9 cases）. Macular ／ punctuate-type keratodermas（8 cases：10.4%） included 4 cases of Darier’s disease. The discrepancy between percentages above and reported incidence of each disorder most likely resulted from the increasing tendency of visits in patients with severe symptoms. The therapeutic approach was application of topical moisturizers, in combination with topical vitamin D3 analogue, steroid, and antibiotics ／ antifungal agents. In addition, some cases were treated with oral retinoids and antihistamines. genetic analysis necessary for diagnosis, this simplified classification based on clinical and changes seems to be useful for and The establishment guidelines in Japan is urgently","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"40 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"131664917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Effect of Ablation Speed in the Endovenous Laser Ablation Using Pulsed 1,320 nm Laser","authors":"Michiaki Sueishi, N. Sakakibara, A. Amano","doi":"10.14789/PJMJ.58.143","DOIUrl":"https://doi.org/10.14789/PJMJ.58.143","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"511 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"115343423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Ogura, M. Hishii, Kazuhisa Takahashi, Atsuko Miyaji, M. Hirama, K. Kido, A. Okuzumi, Toru Kimura, Y. Katsura
{"title":"Pulmonary Metastases from Carotid Body Paraganglioma","authors":"K. Ogura, M. Hishii, Kazuhisa Takahashi, Atsuko Miyaji, M. Hirama, K. Kido, A. Okuzumi, Toru Kimura, Y. Katsura","doi":"10.14789/PJMJ.58.65","DOIUrl":"https://doi.org/10.14789/PJMJ.58.65","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"123391607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
T. Oigawa, Hiromasa Suzuki, S. Sunayama, Sachio KAWAIl, H. Daida
The repair of vascular injury is a concerted response involving complex signaling pathway that contributes to the clinical feature of post─angioplasty restenosis . Vascular injury leads to the activation of various biological cells and the release of numerous vasoactive, thrombogenic, and mitogenic factors in the process of restenosis. Restenosis is histologically attributed to neointimal hyperplasia Original Articles
{"title":"Increased Expression of Oxidative Stress in Proliferated Vascular Smooth Muscle Cells in Early Stage of Human Restenosis After Coronary Angioplasty","authors":"T. Oigawa, Hiromasa Suzuki, S. Sunayama, Sachio KAWAIl, H. Daida","doi":"10.14789/PJMJ.58.35","DOIUrl":"https://doi.org/10.14789/PJMJ.58.35","url":null,"abstract":"The repair of vascular injury is a concerted response involving complex signaling pathway that contributes to the clinical feature of post─angioplasty restenosis . Vascular injury leads to the activation of various biological cells and the release of numerous vasoactive, thrombogenic, and mitogenic factors in the process of restenosis. Restenosis is histologically attributed to neointimal hyperplasia Original Articles","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"23 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-02-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121877574","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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