Glucosamine, a naturally occurring amino monosaccharide, is present in the connective and cartilage tissues as a component of glycosaminoglycans, and contributes to maintaining the strength, flexibility, and elasticity of these tissues. Thus, glucosamine has been widely used to treat osteoarthritis （ OA ） in humans for more than two decades. In fact, several short - and long - term clinical trials on OA have shown the significant symptom - modifying effect of glucosamine. Recently, we have revealed that glucosamine exhibits anti - inflammatory and chondroprotective actions on OA, on the basis of the findings that glucosamine suppresses synovitis and type II collagen degradation, whereas it enhances type II collagen synthesis in articular cartilage, as evidenced by using several biomarkers including hyaluronic acid, CTX - II, C2C, and CPII.
{"title":"CHONDROPROTECTIVE ACTION OF GLUCOSAMINE ON KNEE OSTEOARTHRITIS","authors":"I. Nagaoka","doi":"10.14789/JMJ.59.152","DOIUrl":"https://doi.org/10.14789/JMJ.59.152","url":null,"abstract":"Glucosamine, a naturally occurring amino monosaccharide, is present in the connective and cartilage tissues as a component of glycosaminoglycans, and contributes to maintaining the strength, flexibility, and elasticity of these tissues. Thus, glucosamine has been widely used to treat osteoarthritis （ OA ） in humans for more than two decades. In fact, several short - and long - term clinical trials on OA have shown the significant symptom - modifying effect of glucosamine. Recently, we have revealed that glucosamine exhibits anti - inflammatory and chondroprotective actions on OA, on the basis of the findings that glucosamine suppresses synovitis and type II collagen degradation, whereas it enhances type II collagen synthesis in articular cartilage, as evidenced by using several biomarkers including hyaluronic acid, CTX - II, C2C, and CPII.","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"39 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122431314","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"SURGICAL TREATMENT OF KNEE OSTEOARTHRITIS","authors":"Sung-Gong Kim","doi":"10.14789/JMJ.59.171","DOIUrl":"https://doi.org/10.14789/JMJ.59.171","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"3 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124316910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"THERAPEUTIC EXERCISE PRODUCES LESS PROINFLAMMATORY AND MORE ANTI-INFLAMMATORY CYTOKINES CAUSED BY OSTEOARTHRITIS","authors":"H. Kurosawa","doi":"10.14789/JMJ.59.163","DOIUrl":"https://doi.org/10.14789/JMJ.59.163","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"50 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"121653939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Takemoto, Ken Okamoto, Y. Oode, Y. Sumi, Y. Inoue, S. Matsuda, Hiroshi Tanaka
{"title":"Business Impact Analysis to Prioritize Nursing Operations in Intensive Care Unit","authors":"M. Takemoto, Ken Okamoto, Y. Oode, Y. Sumi, Y. Inoue, S. Matsuda, Hiroshi Tanaka","doi":"10.14789/JMJ.59.65","DOIUrl":"https://doi.org/10.14789/JMJ.59.65","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"76 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124099856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Efficacy of L-Arginine for Benign Prostatic Hyperplasia","authors":"Sosuke Sugimura, Y. Kawachi","doi":"10.14789/JMJ.59.59","DOIUrl":"https://doi.org/10.14789/JMJ.59.59","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"59 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2013-02-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"130182277","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Koyama, Kayo Miura, Suzu Yae, Akiko Murakami, Kazuhisa Takahashi
Lung cancer is the leading cause of cancer─related death. Recently, the incidence of lung cancer, especially for elderly patients, has been increasing in Japan . Over 60% of patients are treated with chemotherapy because of their advanced stages at the time of diagnosis. Recent progress in chemotherapy has significantly prolonged the survival of elderly patients with advanced lung cancer compared to best supportive care . However, not only their survival benefit, but also their quality of life (QOL) during treatment needs to be considered when treatment efficacy is evaluated. In fact, QOL was used as the primary endpoint in the Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) trial and the secondary endpoint in various clinical studies for elderly patients with lung cancer . QOL prior to chemotherapy has been reported to be a useful surrogate marker for the prediction of prognosis . However, there are few reports focusing on the effect of continuation of chemotherapy on the QOL of elderly patients with lung cancer . The aim of this study was to clarify the QOL profiles in elderly patients during chemotherapy in comparison with that in younger patients.
{"title":"Effect of Continuation of Chemotherapy on Quality of Life in Elderly Patients with Lung Cancer -Comparison with That in Younger Patients -","authors":"R. Koyama, Kayo Miura, Suzu Yae, Akiko Murakami, Kazuhisa Takahashi","doi":"10.14789/PJMJ.58.506","DOIUrl":"https://doi.org/10.14789/PJMJ.58.506","url":null,"abstract":"Lung cancer is the leading cause of cancer─related death. Recently, the incidence of lung cancer, especially for elderly patients, has been increasing in Japan . Over 60% of patients are treated with chemotherapy because of their advanced stages at the time of diagnosis. Recent progress in chemotherapy has significantly prolonged the survival of elderly patients with advanced lung cancer compared to best supportive care . However, not only their survival benefit, but also their quality of life (QOL) during treatment needs to be considered when treatment efficacy is evaluated. In fact, QOL was used as the primary endpoint in the Elderly Lung Cancer Vinorelbine Italian Study (ELVIS) trial and the secondary endpoint in various clinical studies for elderly patients with lung cancer . QOL prior to chemotherapy has been reported to be a useful surrogate marker for the prediction of prognosis . However, there are few reports focusing on the effect of continuation of chemotherapy on the QOL of elderly patients with lung cancer . The aim of this study was to clarify the QOL profiles in elderly patients during chemotherapy in comparison with that in younger patients.","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"71 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116618184","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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