Yuki Yoneda, K. Kajimoto, K. Miyauchi, Taira Yamamoto, H. Inaba, K. Tambara, S. Dohi, T. Iwamura, R. Tsuruta, Tomoaki Izawa, H. Daida, A. Amano
{"title":"Gender Differences in Secondary Prevention After Coronary Revascularization: Analysis of Diabetic Patients with Multivessel Disease","authors":"Yuki Yoneda, K. Kajimoto, K. Miyauchi, Taira Yamamoto, H. Inaba, K. Tambara, S. Dohi, T. Iwamura, R. Tsuruta, Tomoaki Izawa, H. Daida, A. Amano","doi":"10.14789/PJMJ.58.409","DOIUrl":"https://doi.org/10.14789/PJMJ.58.409","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"117159704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Kiichi Sugimoto, R. Takahashi, S. Ishiyama, M. Hata, H. Kamiyama, Hiromitsu Komiyama, Makoto Takahashi, Y. Kojima, M. Goto, H. Sengoku, Y. Tomiki, K. Sakamoto
Objective ：It is well known that anti-cancer drugs generate reactive oxygen species and lipoperoxides in cancer patients, and that these free radicals can give rise to adverse events. It has been reported that free radical effects might be attenuated by antioxidants. Recent reports have indicated that Protein-bound polysaccharide K（PSK） exhibits antioxidant effects in addition to its anti-tumor effects. However, there have been few reports investigating whether the antioxidant effects induced by PSK can actually alleviate the adverse events of anti-cancer drugs. In an attempt to alleviate the adverse events and improve completion of oral anti-cancer drugs, we performed a randomized, controlled trial of oral UFT ／ LV plus PSK as postoperative adjuvant chemotherapy for stage II and III colorectal cancer. Materials ：Fifty patients who had undergone curative resection of high-risk stage II or stage III adenocarcinoma of the colon and rectum between May 2008 and May 2010 were enrolled in this study. the a 1：1 The PSK（−） and LV（75mg after and for 6 months or until the diagnosis of tumor recurrence. The PSK（＋） group received PSK（3.0g ／ day） every day in addition to the UFT ／ LV treatment. Patient backgrounds, adverse events, completion of oral administration, laboratory test, stress indices, such as Reactive Oxygen Metabolites Test（d─ROMs Test） and salivary chromogranin A, and NK cell population were analyzed. Results patients（36.0％） and overall adverse events in the PSK（−） and PSK（＋） groups, re-spectively. was no significant difference in the incidence of adverse events between the PSK（−） and PSK（＋） groups. Twenty-two and 23 oral of anti-cancer in the PSK（−） and respectively. There was no significant difference in completion of oral administration between the two groups. In laboratory tests, no significant differences were observed between the two groups. There was no significant difference in the d─ROMs Test between the two groups. Similarly, no significant difference was observed in the salivary chromogranin A. The NK cell population in the PSK（＋） group was significantly higher than that in the PSK（−） group（p＝0.03）.
{"title":"Analysis of the Effects of Alleviating Adverse Events and Improving Completion in Colorectal Cancer Patients with Postoperative Adjuvant Chemotherapy with PSK","authors":"Kiichi Sugimoto, R. Takahashi, S. Ishiyama, M. Hata, H. Kamiyama, Hiromitsu Komiyama, Makoto Takahashi, Y. Kojima, M. Goto, H. Sengoku, Y. Tomiki, K. Sakamoto","doi":"10.14789/PJMJ.58.422","DOIUrl":"https://doi.org/10.14789/PJMJ.58.422","url":null,"abstract":"Objective ：It is well known that anti-cancer drugs generate reactive oxygen species and lipoperoxides in cancer patients, and that these free radicals can give rise to adverse events. It has been reported that free radical effects might be attenuated by antioxidants. Recent reports have indicated that Protein-bound polysaccharide K（PSK） exhibits antioxidant effects in addition to its anti-tumor effects. However, there have been few reports investigating whether the antioxidant effects induced by PSK can actually alleviate the adverse events of anti-cancer drugs. In an attempt to alleviate the adverse events and improve completion of oral anti-cancer drugs, we performed a randomized, controlled trial of oral UFT ／ LV plus PSK as postoperative adjuvant chemotherapy for stage II and III colorectal cancer. Materials ：Fifty patients who had undergone curative resection of high-risk stage II or stage III adenocarcinoma of the colon and rectum between May 2008 and May 2010 were enrolled in this study. the a 1：1 The PSK（−） and LV（75mg after and for 6 months or until the diagnosis of tumor recurrence. The PSK（＋） group received PSK（3.0g ／ day） every day in addition to the UFT ／ LV treatment. Patient backgrounds, adverse events, completion of oral administration, laboratory test, stress indices, such as Reactive Oxygen Metabolites Test（d─ROMs Test） and salivary chromogranin A, and NK cell population were analyzed. Results patients（36.0％） and overall adverse events in the PSK（−） and PSK（＋） groups, re-spectively. was no significant difference in the incidence of adverse events between the PSK（−） and PSK（＋） groups. Twenty-two and 23 oral of anti-cancer in the PSK（−） and respectively. There was no significant difference in completion of oral administration between the two groups. In laboratory tests, no significant differences were observed between the two groups. There was no significant difference in the d─ROMs Test between the two groups. Similarly, no significant difference was observed in the salivary chromogranin A. The NK cell population in the PSK（＋） group was significantly higher than that in the PSK（−） group（p＝0.03）.","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"7 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-10-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114874913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
H. Suganuma, Ayako Kamata, T. Niizuma, Keiji Kinoshita, K. Obinata, Toshiaki Shimizu
{"title":"A Case of Kawasaki Disease Complicated with Acute Pancreatitis After Steroid Pulse Therapy","authors":"H. Suganuma, Ayako Kamata, T. Niizuma, Keiji Kinoshita, K. Obinata, Toshiaki Shimizu","doi":"10.14789/PJMJ.58.344","DOIUrl":"https://doi.org/10.14789/PJMJ.58.344","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"122798480","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Tomoaki Izawa, K. Kajimoto, Taira Yamamoto, K. Miyauchi, H. Inaba, K. Tambara, S. Dohi, T. Iwamura, Yuki Yoneda, R. Tsuruta, H. Daida, A. Amano
disorders, such as higher low-density lipoprotein cholesterol（LDL─C） levels and diabetes mellitus are associated with an increased risk of adverse events in the secondary prevention of coronary artery disease. These metabolic disorders are also associated with adverse events after coronary artery bypass surgery. However, few reports describe the relationship between postoperative outcomes and preoperative serum levels of mediators including levels of fasting blood sugar （FBS）, hemoglobin A1c（HbA1c） and LDL─C. This study assesses the impact of metabolic makers, including LDL─C, on mid-term outcomes of patients with diabetes after off-pump coronary artery bypass surgery. Patients ：We enrolled 350 diabetic patients who underwent isolated off-pump coronary artery bypass surgery at our institu-tion between 2003 and 2007. ：Predictors of all-cause death, cardiac death, and cardiac and cerebrovascular events（MACCE） the Cox proportional-hazards adjusted for LDL─C, FBS and other risk factors at
{"title":"Serum Low-Density Lipoprotein Levels Predict Mid-Term Outcomes of Diabetic Patients After Off-Pump Coronary Artery Bypass Surgery","authors":"Tomoaki Izawa, K. Kajimoto, Taira Yamamoto, K. Miyauchi, H. Inaba, K. Tambara, S. Dohi, T. Iwamura, Yuki Yoneda, R. Tsuruta, H. Daida, A. Amano","doi":"10.14789/PJMJ.58.325","DOIUrl":"https://doi.org/10.14789/PJMJ.58.325","url":null,"abstract":"disorders, such as higher low-density lipoprotein cholesterol（LDL─C） levels and diabetes mellitus are associated with an increased risk of adverse events in the secondary prevention of coronary artery disease. These metabolic disorders are also associated with adverse events after coronary artery bypass surgery. However, few reports describe the relationship between postoperative outcomes and preoperative serum levels of mediators including levels of fasting blood sugar （FBS）, hemoglobin A1c（HbA1c） and LDL─C. This study assesses the impact of metabolic makers, including LDL─C, on mid-term outcomes of patients with diabetes after off-pump coronary artery bypass surgery. Patients ：We enrolled 350 diabetic patients who underwent isolated off-pump coronary artery bypass surgery at our institu-tion between 2003 and 2007. ：Predictors of all-cause death, cardiac death, and cardiac and cerebrovascular events（MACCE） the Cox proportional-hazards adjusted for LDL─C, FBS and other risk factors at","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"156 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"114646948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Morita, M. Iseki, I. Yonezawa, D. Nakahara, J. Sakota, T. Doi, M. Ifuku, Akira Nakao, Yoshitaka Nakamura, E. Inada
{"title":"Risk Factors for Persistent Pain and Disability in Acute to Subacute Sciatica Caused by Lumbar Disk Herniation After Epidural Injections","authors":"Y. Morita, M. Iseki, I. Yonezawa, D. Nakahara, J. Sakota, T. Doi, M. Ifuku, Akira Nakao, Yoshitaka Nakamura, E. Inada","doi":"10.14789/PJMJ.58.231","DOIUrl":"https://doi.org/10.14789/PJMJ.58.231","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"543 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"116201099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
M. Thaha, M. Yusuf, Widodo, R. Anton, Putri N Wenny, Suprapti Budi, Y. Shimizu, Y. Tomino
{"title":"Effect of N-acetylcysteine on Malondyaldehyde Content After Iron Treatment in Chronic Kidney Disease Stage 5D Patients","authors":"M. Thaha, M. Yusuf, Widodo, R. Anton, Putri N Wenny, Suprapti Budi, Y. Shimizu, Y. Tomino","doi":"10.14789/PJMJ.58.238","DOIUrl":"https://doi.org/10.14789/PJMJ.58.238","url":null,"abstract":"","PeriodicalId":223994,"journal":{"name":"Juntendo Medical Journal","volume":"20 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2012-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"124425034","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
京公网安备 11010802042870号
京ICP备2023020795号-1
扫码关注我们
求助内容：
应助结果提醒方式：