Chang-yuan Zhang, Hao Yu, Q. Lin, Y. Taira, Hui Cheng
OBJECTIVE To evaluate the bond strength of fiber posts to intraradicular dentine pretreated with two root canal obturation techniques and three postspace irrigation solutions. METHODS A total of 96 human premolars were collected and treated with complete or partial root canal obturation techniques. The roots were further divided into three subgroups (n = 16) based on postspace irrigation solutions: 2.5% NaOCl, 37% phosphoric acid etching, and distilled water. The fiber posts were bonded with self-adhesive resin cement, and the roots were sectioned into three slices (cervical, middle, and apical regions) after 5,000 thermocycles. The push-out bond strengths were determined and subjected to analysis of variance (α = 0.05). A stereomicroscope was used to observe the failure modes of the specimens. RESULTS The irrigation solution, root canal obturation technique, and root region had significant effects on bond strength (P < 0.001). The completely obturated root canals showed significantly lower bond strength than the partially obturated root canals. The 2.5% NaOCl treatment produced the highest bond strength among the three irrigation solutions. Among the root regions, the cervical part showed significantly greater bond strength than the middle and apical parts. The most common failure mode was mixed failure. CONCLUSION The partial root canal obturation technique provided better bond strength of the fiber post to intraradicular dentine. Irrigation with 2.5% NaOCl solution and phosphoric acid etching before cementation improved the push-out bond strength of the fiber posts to intraradicular dentine.
{"title":"Effects of Different Root Canal Obturation Techniques on the Bond Strength of Fiber Post to Intraradicular Dentine.","authors":"Chang-yuan Zhang, Hao Yu, Q. Lin, Y. Taira, Hui Cheng","doi":"10.3290/j.cjdr.a43113","DOIUrl":"https://doi.org/10.3290/j.cjdr.a43113","url":null,"abstract":"OBJECTIVE To evaluate the bond strength of fiber posts to intraradicular dentine pretreated with two root canal obturation techniques and three postspace irrigation solutions. METHODS A total of 96 human premolars were collected and treated with complete or partial root canal obturation techniques. The roots were further divided into three subgroups (n = 16) based on postspace irrigation solutions: 2.5% NaOCl, 37% phosphoric acid etching, and distilled water. The fiber posts were bonded with self-adhesive resin cement, and the roots were sectioned into three slices (cervical, middle, and apical regions) after 5,000 thermocycles. The push-out bond strengths were determined and subjected to analysis of variance (α = 0.05). A stereomicroscope was used to observe the failure modes of the specimens. RESULTS The irrigation solution, root canal obturation technique, and root region had significant effects on bond strength (P < 0.001). The completely obturated root canals showed significantly lower bond strength than the partially obturated root canals. The 2.5% NaOCl treatment produced the highest bond strength among the three irrigation solutions. Among the root regions, the cervical part showed significantly greater bond strength than the middle and apical parts. The most common failure mode was mixed failure. CONCLUSION The partial root canal obturation technique provided better bond strength of the fiber post to intraradicular dentine. Irrigation with 2.5% NaOCl solution and phosphoric acid etching before cementation improved the push-out bond strength of the fiber posts to intraradicular dentine.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"39 1","pages":"189-196"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77848769","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
W. Zhang, Yang Wang, C. Mao, Chuan-Bin Guo, G. Yu, Xin Peng
OBJECTIVE To increase the awareness of oral squamous cell carcinoma (OSCC) metastasis to the parotid region and the characteristics of these cases, and to evaluate the outcomes and provide treatment suggestions. METHODS A retrospective study was conducted among the OSCC patients with metastasis to the parotid gland at the Peking University School and Hospital of Stomatology from 2000 to 2015. The demographic data and the medical records including primary tumour, treatment protocol, follow-up information and outcomes were collected and analysed. RESULTS A total of 10 patients with parotid metastasis (out of 1358 OSCC patients) were included in the study. The incidence of parotid metastasis was relatively low (0.74%). All the cases were poorly differentiated (Grade II/III) and the primary sites were in an advanced stage (T3/4). Parotid metastasis occurred frequently following neck dissection and radiotherapy, and the inferior parotid lymph nodes were most commonly involved. Surgery and radiotherapy were mainly salvage protocols for parotid metastasis. The 5-year survival rate of these patients was 38.9% by the Kaplan-Meier method. CONCLUSION OSCC has the potential to metastasise into the parotid lymph nodes. The salvage rate and prognosis were relatively poor. Removing of the parotid tail along with the neck dissection is recommended for OSCC patients.
{"title":"Oral Squamous Cell Carcinoma with Metastasis to the Parotid Lymph Node.","authors":"W. Zhang, Yang Wang, C. Mao, Chuan-Bin Guo, G. Yu, Xin Peng","doi":"10.3290/j.cjdr.a43111","DOIUrl":"https://doi.org/10.3290/j.cjdr.a43111","url":null,"abstract":"OBJECTIVE To increase the awareness of oral squamous cell carcinoma (OSCC) metastasis to the parotid region and the characteristics of these cases, and to evaluate the outcomes and provide treatment suggestions. METHODS A retrospective study was conducted among the OSCC patients with metastasis to the parotid gland at the Peking University School and Hospital of Stomatology from 2000 to 2015. The demographic data and the medical records including primary tumour, treatment protocol, follow-up information and outcomes were collected and analysed. RESULTS A total of 10 patients with parotid metastasis (out of 1358 OSCC patients) were included in the study. The incidence of parotid metastasis was relatively low (0.74%). All the cases were poorly differentiated (Grade II/III) and the primary sites were in an advanced stage (T3/4). Parotid metastasis occurred frequently following neck dissection and radiotherapy, and the inferior parotid lymph nodes were most commonly involved. Surgery and radiotherapy were mainly salvage protocols for parotid metastasis. The 5-year survival rate of these patients was 38.9% by the Kaplan-Meier method. CONCLUSION OSCC has the potential to metastasise into the parotid lymph nodes. The salvage rate and prognosis were relatively poor. Removing of the parotid tail along with the neck dissection is recommended for OSCC patients.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"22 1","pages":"175-179"},"PeriodicalIF":0.0,"publicationDate":"2019-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89028228","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Cheng Wang, Xi Liu, Jin-song Hou, Jian Wang, H. Huang
Oral cancer is an aggressive disease with the propensity for local recurrence and distal metastasis in the head and neck region. Currently, cisplatin-based chemotherapy or concurrent radiochemotherapy is still the first choice to treat the advanced stage cancers, in particular, the unresectable tumours. Unfortunately, innate and acquired resistance to chemotherapy agent greatly limited its effectiveness and often led to treatment failure in these patients. Hence, it is urgent to clarify the mechanisms underlying the development of chemoresistance in patients with oral cancer. In this article, the current understandings on molecular mechanisms of chemoresistance in oral cancer were reviewed, including drug efflux, apoptosis, DNA damage and repair, epithelial mesenchymal transition, autophagy and miRNA.
{"title":"Molecular Mechanisms of Chemoresistance in Oral Cancer.","authors":"Cheng Wang, Xi Liu, Jin-song Hou, Jian Wang, H. Huang","doi":"10.3290/j.cjdr.a35694","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35694","url":null,"abstract":"Oral cancer is an aggressive disease with the propensity for local recurrence and distal metastasis in the head and neck region. Currently, cisplatin-based chemotherapy or concurrent radiochemotherapy is still the first choice to treat the advanced stage cancers, in particular, the unresectable tumours. Unfortunately, innate and acquired resistance to chemotherapy agent greatly limited its effectiveness and often led to treatment failure in these patients. Hence, it is urgent to clarify the mechanisms underlying the development of chemoresistance in patients with oral cancer. In this article, the current understandings on molecular mechanisms of chemoresistance in oral cancer were reviewed, including drug efflux, apoptosis, DNA damage and repair, epithelial mesenchymal transition, autophagy and miRNA.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"134 1","pages":"25-33"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88911850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Yansong Ma, Dong-yu Fang, Ning Zhang, X. Ding, Kun-ya Zhang, Yuxing Bai
OBJECTIVE To characterise and compare the tensile characteristics after multi-proportional blending, to determine the proper blending ratio for new thermoplastic material and to compare its mechanical performance with commercial thermoplastics. METHODS PETG and PC2858 aggregates were blended in five different ratios. Standard specimens of each ratio were molded and tested to determine their mechanical performance. Then the new material with the proper blending ratio was chosen and compared against commercial thermoplastics. RESULTS With the increase of PC2858 content, the tensile and impact strength increased but elongation at break decreased. When blending ratio (wt %) was 70/30, the PETG/PC2858 exhibited optimal mechanical properties, with a tensile strength of 63.42 ± 1.67 MPa, and a stress relaxation rate of 0.0080 ± 0.0005 N/s, which exceeded those of Erkodur and Biolon. CONCLUSION By blending PETG and PC2858 at the weight ratio 70/30, we obtained new thermoplastic material which outperformed commercial products.
{"title":"Mechanical Properties of Orthodontic Thermoplastics PETG/ PC2858 after Blending.","authors":"Yansong Ma, Dong-yu Fang, Ning Zhang, X. Ding, Kun-ya Zhang, Yuxing Bai","doi":"10.3290/j.cjdr.a35696","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35696","url":null,"abstract":"OBJECTIVE\u0000To characterise and compare the tensile characteristics after multi-proportional blending, to determine the proper blending ratio for new thermoplastic material and to compare its mechanical performance with commercial thermoplastics.\u0000\u0000\u0000METHODS\u0000PETG and PC2858 aggregates were blended in five different ratios. Standard specimens of each ratio were molded and tested to determine their mechanical performance. Then the new material with the proper blending ratio was chosen and compared against commercial thermoplastics.\u0000\u0000\u0000RESULTS\u0000With the increase of PC2858 content, the tensile and impact strength increased but elongation at break decreased. When blending ratio (wt %) was 70/30, the PETG/PC2858 exhibited optimal mechanical properties, with a tensile strength of 63.42 ± 1.67 MPa, and a stress relaxation rate of 0.0080 ± 0.0005 N/s, which exceeded those of Erkodur and Biolon.\u0000\u0000\u0000CONCLUSION\u0000By blending PETG and PC2858 at the weight ratio 70/30, we obtained new thermoplastic material which outperformed commercial products.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"72 1","pages":"43-8"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88478931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVE To explore the effectiveness of comprehensive oral health care to reduce the caries incidence for children with severe early childhood caries (s-ECC) in an urban area in China. METHODS A total of 357 children aged 3 to 4 years old and diagnosed with s-ECC were recruited in this randomised controlled, single-blinded clinical trial for 1 year. Children of two different kindergarten classes were enrolled in this study and randomly divided into a test group (205 children) and a control group (152 children). The test group received comprehensive oral health care, which included: oral health examination, oral health education, topical fluoride application and dental treatment, and the children in the control group only received the oral health examination. The evaluation of the oral health questionnaire for parents was also performed. An evaluation was carried out at the time of recruitment and 1 year later to explore the effectiveness of the comprehensive oral health care model. RESULTS The differences in decayed teeth (dt), decayed tooth surfaces (ds), filled teeth (ft), filled tooth surfaces (fs) and the ratio of ft /(dt + ft) between the two groups were statistically significant (P < 0.001) at 1 year. The incidence of caries in the control group was higher than that of the test group (P = 0.02). The rate of awareness of oral health knowledge (P = 0.01) and the practice of good diet habits (P = 0.02) by parents in the test group were significantly higher than those in the control group. CONCLUSION The present study demonstrated that the comprehensive oral health care program reduces and prevents caries amongst children with s-ECC.
{"title":"Comprehensive Oral Health Care to Reduce the Incidence of Severe Early Childhood Caries (s-ECC) in Urban China.","authors":"Y. Si, Yanbing Guo, C. Yuan, Tao Xu, S. Zheng","doi":"10.3290/j.cjdr.a35698","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35698","url":null,"abstract":"OBJECTIVE\u0000To explore the effectiveness of comprehensive oral health care to reduce the caries incidence for children with severe early childhood caries (s-ECC) in an urban area in China.\u0000\u0000\u0000METHODS\u0000A total of 357 children aged 3 to 4 years old and diagnosed with s-ECC were recruited in this randomised controlled, single-blinded clinical trial for 1 year. Children of two different kindergarten classes were enrolled in this study and randomly divided into a test group (205 children) and a control group (152 children). The test group received comprehensive oral health care, which included: oral health examination, oral health education, topical fluoride application and dental treatment, and the children in the control group only received the oral health examination. The evaluation of the oral health questionnaire for parents was also performed. An evaluation was carried out at the time of recruitment and 1 year later to explore the effectiveness of the comprehensive oral health care model.\u0000\u0000\u0000RESULTS\u0000The differences in decayed teeth (dt), decayed tooth surfaces (ds), filled teeth (ft), filled tooth surfaces (fs) and the ratio of ft /(dt + ft) between the two groups were statistically significant (P < 0.001) at 1 year. The incidence of caries in the control group was higher than that of the test group (P = 0.02). The rate of awareness of oral health knowledge (P = 0.01) and the practice of good diet habits (P = 0.02) by parents in the test group were significantly higher than those in the control group.\u0000\u0000\u0000CONCLUSION\u0000The present study demonstrated that the comprehensive oral health care program reduces and prevents caries amongst children with s-ECC.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"1 1","pages":"55-63"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85477928","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVE To evaluate the use of platelet-rich fibrin (PRF) in the regenerative therapy of immature canine permanent teeth. METHODS Eight immature premolars of beagle dogs were pulp extracted and cleaned with irrigation, then divided into two groups of empty root canals and those filled with a PRF clot. All of the eight premolars were sealed with mineral trioxide aggregate and glass ionomer cement. Two premolars were left naturally grown as a positive control. The root development was assessed radiographically and histologically after 12 weeks. RESULTS The radiological findings showed greater increases in the thickness of lateral dentinal wall in the PRF group than in the vacant group. Histologically, dental-associated mineral tissue, connective tissue, and bone-like mineral tissue grew into the root canals independent of PRF clot use. The PRF was able to increase the thickness of dental-associated mineral tissue. However, the vital tissue differed from the pulp dentin complex. CONCLUSION Our study demonstrated the feasibility of using PRF-mediated regenerative therapy in pulpless immature teeth for improving tissue repair.
{"title":"Preliminary Evaluation of Platelet Rich Fibrin-Mediated Tissue Repair in Immature Canine Pulpless Teeth.","authors":"Qi Lin Wang, Pan-Pan Yang, L. Ge, He Liu","doi":"10.3290/j.cjdr.a35697","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35697","url":null,"abstract":"OBJECTIVE\u0000To evaluate the use of platelet-rich fibrin (PRF) in the regenerative therapy of immature canine permanent teeth.\u0000\u0000\u0000METHODS\u0000Eight immature premolars of beagle dogs were pulp extracted and cleaned with irrigation, then divided into two groups of empty root canals and those filled with a PRF clot. All of the eight premolars were sealed with mineral trioxide aggregate and glass ionomer cement. Two premolars were left naturally grown as a positive control. The root development was assessed radiographically and histologically after 12 weeks.\u0000\u0000\u0000RESULTS\u0000The radiological findings showed greater increases in the thickness of lateral dentinal wall in the PRF group than in the vacant group. Histologically, dental-associated mineral tissue, connective tissue, and bone-like mineral tissue grew into the root canals independent of PRF clot use. The PRF was able to increase the thickness of dental-associated mineral tissue. However, the vital tissue differed from the pulp dentin complex.\u0000\u0000\u0000CONCLUSION\u0000Our study demonstrated the feasibility of using PRF-mediated regenerative therapy in pulpless immature teeth for improving tissue repair.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"45 1","pages":"49-54"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84816533","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Time flies and the new year of 2016 has finally arrived. Introduction.","authors":"G. Yu","doi":"10.3290/j.cjdr.a35783","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35783","url":null,"abstract":"","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"37 1","pages":"7"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81676053","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The human papilloma virus (HPV) is a common virus that infects epithelium in 10% of the world's population. While most sexually active people become infected, the majority with a healthy natural immunity control their infection. When the infection becomes persistent in cervical mucosa for instance, it is associated with nearly all cervical cancers. Fortunately cervical cancer screening is both sensitive and specific and when accessed has led to significant reductions of this disease. Despite this, cervical cancer still remains one of the leading causes of death from cancer. Oropharyngeal mucosa is becoming persistently infected with HPV in an increasing number of people leading to a potential epidemic of oropharyngeal carcinoma. While only 10% of new oropharyngeal infections persist, those in elderly men who smoke are more likely to do so. Some centres report more than 70% of oropharyngeal cancers are associated with HPV infection, which is different to cancers caused by alcohol and tobacco. Other centres report only a 20% association. Education against high-risk sexual behaviour has been met with limited success. Screening for oropharyngeal HPV infection has been disappointing with a pickup rate of only 40%. Some hope lies in detecting viral DNA in both the saliva and plasma. A HPV vaccine has been available since 2006 but is not yet routinely given to both sexes in many countries. Its effect on the incidence of HPV-positive oropharyngeal carcinomas is currently unknown. Vigilance by dental and medical colleagues in the meantime is essential.
{"title":"Human Papilloma Virus and Oropharyngeal Carcinoma - Lessons from History.","authors":"A. Vlantis","doi":"10.3290/j.cjdr.a35692","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35692","url":null,"abstract":"The human papilloma virus (HPV) is a common virus that infects epithelium in 10% of the world's population. While most sexually active people become infected, the majority with a healthy natural immunity control their infection. When the infection becomes persistent in cervical mucosa for instance, it is associated with nearly all cervical cancers. Fortunately cervical cancer screening is both sensitive and specific and when accessed has led to significant reductions of this disease. Despite this, cervical cancer still remains one of the leading causes of death from cancer. Oropharyngeal mucosa is becoming persistently infected with HPV in an increasing number of people leading to a potential epidemic of oropharyngeal carcinoma. While only 10% of new oropharyngeal infections persist, those in elderly men who smoke are more likely to do so. Some centres report more than 70% of oropharyngeal cancers are associated with HPV infection, which is different to cancers caused by alcohol and tobacco. Other centres report only a 20% association. Education against high-risk sexual behaviour has been met with limited success. Screening for oropharyngeal HPV infection has been disappointing with a pickup rate of only 40%. Some hope lies in detecting viral DNA in both the saliva and plasma. A HPV vaccine has been available since 2006 but is not yet routinely given to both sexes in many countries. Its effect on the incidence of HPV-positive oropharyngeal carcinomas is currently unknown. Vigilance by dental and medical colleagues in the meantime is essential.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"20 1","pages":"9-16"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83539780","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
OBJECTIVE To investigate the association between the analgesic effect of non-steroidal antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1.7) expression in the trigeminal ganglion (TG). METHODS Temporomandibular joint (TMJ) inflammation was induced by complete Freund's adjuvant (CFA) in female rats. Ibuprofen, diclofenac sodium and meloxicam were given intragastrically before induction of TMJ inflammation. Histopathological evaluation and scoring of TMJ inflammation was used to evaluate the level of inflammation. The head withdrawal threshold and food intake were measured to evaluate TMJ nociceptive responses. The mRNA and protein expression of trigeminal ganglionic Nav1.7 was examined using real-time polymerase chain reaction and western blot. RESULTS Twenty-four hours after the injection of CFA into the TMJs, NSAIDs attenuated hyperalgesia of inflamed TMJ and simultaneously blocked inflammation-induced upregulation of Nav1.7 mRNA and protein expression in the TG. However, ibuprofen and diclofenac sodium slightly attenuated TMJ inflammation and meloxicam did not affect TMJ inflammation. CONCLUSION Attenuation of hyperalgesia of inflamed TMJ by NSAIDs might be associated with their role in blocking upregulation of trigeminal ganglionic Nav1.7.
{"title":"Non-steroidal Anti-inflammatory Drugs Attenuate Hyperalgesia and Block Upregulation of Trigeminal Ganglionic Sodium Channel 1.7 after Induction of Temporomandibular Joint Inflammation in Rats.","authors":"Rui-yun Bi, Yun Ding, Y. Gan","doi":"10.3290/j.cjdr.a35695","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35695","url":null,"abstract":"OBJECTIVE\u0000To investigate the association between the analgesic effect of non-steroidal antiinflammatory drugs (NSAIDs) and sodium channel 1.7 (Nav1.7) expression in the trigeminal ganglion (TG).\u0000\u0000\u0000METHODS\u0000Temporomandibular joint (TMJ) inflammation was induced by complete Freund's adjuvant (CFA) in female rats. Ibuprofen, diclofenac sodium and meloxicam were given intragastrically before induction of TMJ inflammation. Histopathological evaluation and scoring of TMJ inflammation was used to evaluate the level of inflammation. The head withdrawal threshold and food intake were measured to evaluate TMJ nociceptive responses. The mRNA and protein expression of trigeminal ganglionic Nav1.7 was examined using real-time polymerase chain reaction and western blot.\u0000\u0000\u0000RESULTS\u0000Twenty-four hours after the injection of CFA into the TMJs, NSAIDs attenuated hyperalgesia of inflamed TMJ and simultaneously blocked inflammation-induced upregulation of Nav1.7 mRNA and protein expression in the TG. However, ibuprofen and diclofenac sodium slightly attenuated TMJ inflammation and meloxicam did not affect TMJ inflammation.\u0000\u0000\u0000CONCLUSION\u0000Attenuation of hyperalgesia of inflamed TMJ by NSAIDs might be associated with their role in blocking upregulation of trigeminal ganglionic Nav1.7.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"40 1","pages":"35-42"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80866456","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Komal Khot, Swati P. Deshmane, Sheetal S Choudhari
Squamous cell carcinoma of the head and neck (HNSCC) has long been regarded as a disease entity having a remarkable incidence worldwide and a fairly onerous prognosis; thus encouraging further research on factors that might modify disease outcome. Squamous cell carcinomas encompass at least 90% of all oral malignancies. Several factors like tobacco and tobacco-related products, alcohol, genetic predisposition and hormonal factors are suspected as possible causative factors. Human papilloma virus (HPV), the causal agent of cervical cancer also appears to be involved in the aetiology of oral and oropharyngeal cancer. HPVpositive squamous cell carcinoma (SCC) seems to differ from HPV-negative SCC. Many questions about the natural history of oral HPV infection remain under investigation. The aim of this review is to highlight the current understanding of HPV-associated oral cancer with an emphasis on its prognosis, detection and management.
{"title":"Human Papilloma Virus in Oral Squamous Cell Carcinoma - The Enigma Unravelled.","authors":"Komal Khot, Swati P. Deshmane, Sheetal S Choudhari","doi":"10.3290/j.cjdr.a35693","DOIUrl":"https://doi.org/10.3290/j.cjdr.a35693","url":null,"abstract":"Squamous cell carcinoma of the head and neck (HNSCC) has long been regarded as a disease entity having a remarkable incidence worldwide and a fairly onerous prognosis; thus encouraging further research on factors that might modify disease outcome. Squamous cell carcinomas encompass at least 90% of all oral malignancies. Several factors like tobacco and tobacco-related products, alcohol, genetic predisposition and hormonal factors are suspected as possible causative factors. Human papilloma virus (HPV), the causal agent of cervical cancer also appears to be involved in the aetiology of oral and oropharyngeal cancer. HPVpositive squamous cell carcinoma (SCC) seems to differ from HPV-negative SCC. Many questions about the natural history of oral HPV infection remain under investigation. The aim of this review is to highlight the current understanding of HPV-associated oral cancer with an emphasis on its prognosis, detection and management.","PeriodicalId":22405,"journal":{"name":"The Chinese journal of dental research : the official journal of the Scientific Section of the Chinese Stomatological Association","volume":"14 1","pages":"17-23"},"PeriodicalIF":0.0,"publicationDate":"2016-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82422373","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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