Pub Date : 2021-02-18DOI: 10.21608/EJH.2021.58761.1421
Hekmat A. Sorour, Dina Abdelmaksoud, Mona Mohamed Abd Elgalil
{"title":"The Impact of High Fat Diet and Flaxseed on Liver Histology, Histochemistry and Morphometry in Ovariectomized Albino Rat","authors":"Hekmat A. Sorour, Dina Abdelmaksoud, Mona Mohamed Abd Elgalil","doi":"10.21608/EJH.2021.58761.1421","DOIUrl":"https://doi.org/10.21608/EJH.2021.58761.1421","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"1 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86290224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-16DOI: 10.21608/EJH.2021.37139.1334
Elsayed Metwally, A. Nawar
Background: Osteoarthritis is the most prevalent type of arthritis. It is an important cause of pain and disability in elder adults. Trimetazidine and sitagliptin have anti-inflammatory effects. Material and Methods: Fifty adult Wister male albino rats divided into 4 groups. Group Ι: Five rats received a single dose of 1ml 0.9% saline intra-articular. Group ΙΙ: Fifteen rats received a single dose of 1mg monosodium iodoacetate (MIA) diluted in 0.9% saline intra-articular and 1 ml of 1% gum acacia per gavage daily for 4 weeks. Group III: Fifteen rats received a single dose of 1mg MIA diluted in 0.9% saline intra-articular concomitant with oral administration of trimetazidine suspended in 1% gum acacia, in a dose of 10 mg/kg/day for 4 weeks. Group IV: Fifteen rats received a single dose of 1mg MIA diluted in 0.9% saline intra-articular concomitant with oral administration of sitagliptin suspended in 1% gum acacia, in a dose of 10 mg/kg/day for 4 weeks.Results: Intra-articular injection of MIA induced arthritis. Trimetazidine and sitagliptin insignificantly increased the circulating levels of serum inflammatory cytokines; COMP, IL-1 β, and TNF α. While the circulating levels of TGF-β1 in the arthritis group was significantly reduced compared to the control group. Concomitant administration of trimetazidine with MIA showed normal organized chondrocytes and normal bone trabeculae. Concomitant administration of sitagliptin showed improvement of histological features, normal organized chondrocytes, normal bone trabeculae and decreased resorption cavities. Histomorphometric evaluation of the percent area of the articular cartilage thickness revealed a significant decrease in arthritis group and a significant rise in both sitagliptin and trimetazidine groups.Conclusion: Sitagliptin and trimetazidine may have protective effect against arthritis.
{"title":"The possible Effect of Trimetazidine and Sitagliptin on Chronic Model of Arthritis in Male Albino rats; Histomorphometric study","authors":"Elsayed Metwally, A. Nawar","doi":"10.21608/EJH.2021.37139.1334","DOIUrl":"https://doi.org/10.21608/EJH.2021.37139.1334","url":null,"abstract":"Background: Osteoarthritis is the most prevalent type of arthritis. It is an important cause of pain and disability in elder adults. Trimetazidine and sitagliptin have anti-inflammatory effects. Material and Methods: Fifty adult Wister male albino rats divided into 4 groups. Group Ι: Five rats received a single dose of 1ml 0.9% saline intra-articular. Group ΙΙ: Fifteen rats received a single dose of 1mg monosodium iodoacetate (MIA) diluted in 0.9% saline intra-articular and 1 ml of 1% gum acacia per gavage daily for 4 weeks. Group III: Fifteen rats received a single dose of 1mg MIA diluted in 0.9% saline intra-articular concomitant with oral administration of trimetazidine suspended in 1% gum acacia, in a dose of 10 mg/kg/day for 4 weeks. Group IV: Fifteen rats received a single dose of 1mg MIA diluted in 0.9% saline intra-articular concomitant with oral administration of sitagliptin suspended in 1% gum acacia, in a dose of 10 mg/kg/day for 4 weeks.Results: Intra-articular injection of MIA induced arthritis. Trimetazidine and sitagliptin insignificantly increased the circulating levels of serum inflammatory cytokines; COMP, IL-1 β, and TNF α. While the circulating levels of TGF-β1 in the arthritis group was significantly reduced compared to the control group. Concomitant administration of trimetazidine with MIA showed normal organized chondrocytes and normal bone trabeculae. Concomitant administration of sitagliptin showed improvement of histological features, normal organized chondrocytes, normal bone trabeculae and decreased resorption cavities. Histomorphometric evaluation of the percent area of the articular cartilage thickness revealed a significant decrease in arthritis group and a significant rise in both sitagliptin and trimetazidine groups.Conclusion: Sitagliptin and trimetazidine may have protective effect against arthritis.","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"174 3-4","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91489002","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-10DOI: 10.21608/EJH.2021.55987.1409
Sara Mohamed, S. Radwan, S. Atta, S. Hosny
Abstract: -Background and objectives: Methotrexate (MTX) is an antirheumatic and chemotherapeutic agent with highly adverse effect on gastrointestinal tract. Mesenchymal stem cell (MSCs) can exert a therapeutic action by regenerative capacity in intestinal damage. This study was done to demonstrate the possible therapeutic effect of MSCs in methotrexate induced intestinal injury in adult male albino rat.Methods and results: Male albino rats were used in this study. Group A (Control group), subgroup A-I rats received saline for 2 weeks and subgroup A-II received saline for 2 weeks then phosphate buffer saline once intraperitoneal (IP). Group B rats received MTX (14 mg/kg/week) intraperitoneal (IP) for 2 weeks. Group C, rats received MTX (14 mg/kg/week) intraperitoneal (IP) for 2 weeks. After 2 weeks, they were injected IP with MSCs (2 × 106 cells in 500 𝜇L PBS once). Groups AI&B were anaesthetized and sacrificed after 2 weeks while groups AII&C were sacrificed after 4 weeks. Blood samples were drawn from the tail vein to measure myeloperoxidase (MPO) and vascular endothelial growth factor (VEGF). Small intestinal specimens were obtained for evaluation by light microscopy. CD4+, and CD8+ immunohistochemistry and statistical analysis were applied. Significant increase in MPO and significant decrease in VEGF were reported in Group B. MTX induced pathological alterations in small intestinal tissues, mean number of mast cells and goblet cells associated with increased CD4+ and CD8+ immunoexpression. Nearly all changes were ameliorated following MSCs therapyConclusion: MSCs have significant effect in repairing the deleterious action of MTX in small intestinal tissues.
{"title":"A histological study for the possible therapeutic effect of stem cells in methotrexate induced small intestinal injury in a male rat model","authors":"Sara Mohamed, S. Radwan, S. Atta, S. Hosny","doi":"10.21608/EJH.2021.55987.1409","DOIUrl":"https://doi.org/10.21608/EJH.2021.55987.1409","url":null,"abstract":"Abstract: -Background and objectives: Methotrexate (MTX) is an antirheumatic and chemotherapeutic agent with highly adverse effect on gastrointestinal tract. Mesenchymal stem cell (MSCs) can exert a therapeutic action by regenerative capacity in intestinal damage. This study was done to demonstrate the possible therapeutic effect of MSCs in methotrexate induced intestinal injury in adult male albino rat.Methods and results: Male albino rats were used in this study. Group A (Control group), subgroup A-I rats received saline for 2 weeks and subgroup A-II received saline for 2 weeks then phosphate buffer saline once intraperitoneal (IP). Group B rats received MTX (14 mg/kg/week) intraperitoneal (IP) for 2 weeks. Group C, rats received MTX (14 mg/kg/week) intraperitoneal (IP) for 2 weeks. After 2 weeks, they were injected IP with MSCs (2 × 106 cells in 500 𝜇L PBS once). Groups AI&B were anaesthetized and sacrificed after 2 weeks while groups AII&C were sacrificed after 4 weeks. Blood samples were drawn from the tail vein to measure myeloperoxidase (MPO) and vascular endothelial growth factor (VEGF). Small intestinal specimens were obtained for evaluation by light microscopy. CD4+, and CD8+ immunohistochemistry and statistical analysis were applied. Significant increase in MPO and significant decrease in VEGF were reported in Group B. MTX induced pathological alterations in small intestinal tissues, mean number of mast cells and goblet cells associated with increased CD4+ and CD8+ immunoexpression. Nearly all changes were ameliorated following MSCs therapyConclusion: MSCs have significant effect in repairing the deleterious action of MTX in small intestinal tissues.","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"91 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85214286","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-10DOI: 10.21608/EJH.2021.58210.1418
I. Nabil, Wafaa Ahmed, Salwa El Sabeh, Rana Abouelrous, Nancy M. El Sekily
{"title":"The possible protective effect of aldehyde dehydrogenase 2 agonist (Alda-1) on doxorubicin induced toxicity of the left ventricular cardiomyocytes of adult male mice.","authors":"I. Nabil, Wafaa Ahmed, Salwa El Sabeh, Rana Abouelrous, Nancy M. El Sekily","doi":"10.21608/EJH.2021.58210.1418","DOIUrl":"https://doi.org/10.21608/EJH.2021.58210.1418","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"27 3 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79833762","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-08DOI: 10.21608/EJH.2021.57128.1413
H. Mohamed, Heba K Mohamed
Background: Anabolic androgenic steroids (AAS ) abuse is considered as a public issue as a result of their widespread use to enhance muscular building .Aim of the work: The aim of the study is to clarify the hazards effects that occurred in the skeletal muscles of adult male albino rats as a result of administration of Nandrolone Decanoate histologically as well as immunohistochemically and the possible role of the interaction between (AAS) and training exercise . Materials and Methods: Forty adult male albino rats were divided randomly into four groups; group I (control group ) , group II (steroids treated group ), group III (trained group ) and group IV (steroid treated-trained group) . Both groups II and IV were administered 5 mg/kg body weight, of Nandrolone Decanoate twice a week by intramuscular injection for 5weeks. Group III and Group IV were subjected to training protocol in the form of 4 sets of 10 jumps into water for 5 weeks . At the end of the experiments the rats were sacrificed and their quadriceps muscles were processed for histological and immunohistochemically procedures .Results: Group II (steroid treated group) had hypertrophy of muscle fibers and disrupted striations with wide spacing between them. In addition to areas of degeneration and congested blood vessels. Group III had hypertrophy of muscle fibers. Group IV exhibited normal histological appearance of the muscle fibers. Minute areas of focal degeneration and congested blood vessels were observed.Conclusion: Administration of (AAS) was presented with noticeable degenerative changes in the quadriceps muscles of the adult male albino rats . These hazards effects could be attenuated in the group of rats that were subjected to (AAS) in concomitant with training exercise.
{"title":"Histological and immunohistochemical studies of the effects of administration of anabolic androgenic steroids alone and in concomitant with training exercise on the adult male rats skeletal muscles","authors":"H. Mohamed, Heba K Mohamed","doi":"10.21608/EJH.2021.57128.1413","DOIUrl":"https://doi.org/10.21608/EJH.2021.57128.1413","url":null,"abstract":"Background: Anabolic androgenic steroids (AAS ) abuse is considered as a public issue as a result of their widespread use to enhance muscular building .Aim of the work: The aim of the study is to clarify the hazards effects that occurred in the skeletal muscles of adult male albino rats as a result of administration of Nandrolone Decanoate histologically as well as immunohistochemically and the possible role of the interaction between (AAS) and training exercise . Materials and Methods: Forty adult male albino rats were divided randomly into four groups; group I (control group ) , group II (steroids treated group ), group III (trained group ) and group IV (steroid treated-trained group) . Both groups II and IV were administered 5 mg/kg body weight, of Nandrolone Decanoate twice a week by intramuscular injection for 5weeks. Group III and Group IV were subjected to training protocol in the form of 4 sets of 10 jumps into water for 5 weeks . At the end of the experiments the rats were sacrificed and their quadriceps muscles were processed for histological and immunohistochemically procedures .Results: Group II (steroid treated group) had hypertrophy of muscle fibers and disrupted striations with wide spacing between them. In addition to areas of degeneration and congested blood vessels. Group III had hypertrophy of muscle fibers. Group IV exhibited normal histological appearance of the muscle fibers. Minute areas of focal degeneration and congested blood vessels were observed.Conclusion: Administration of (AAS) was presented with noticeable degenerative changes in the quadriceps muscles of the adult male albino rats . These hazards effects could be attenuated in the group of rats that were subjected to (AAS) in concomitant with training exercise.","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"378 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74869428","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-04DOI: 10.21608/EJH.2021.57674.1415
M. Abdeen, Dorrya Zaghloul, R. Saleh, A. Abdelmalek
{"title":"Histomorphometric Evidence of Hepatic Recovery of Rats Fed Repeatedly Heated Palm Oil","authors":"M. Abdeen, Dorrya Zaghloul, R. Saleh, A. Abdelmalek","doi":"10.21608/EJH.2021.57674.1415","DOIUrl":"https://doi.org/10.21608/EJH.2021.57674.1415","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"1 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84733682","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-02DOI: 10.21608/EJH.2021.52908.1399
S. S. Elabd, M. Ibrahim, M. Sadek
{"title":"Effect of Tadalafil on Apoptosis and Proliferation in Urinary Bladder Mucosa after Chemically Induced Haemorrhagic Cystitis; A Histological and Immunohistochemical Study","authors":"S. S. Elabd, M. Ibrahim, M. Sadek","doi":"10.21608/EJH.2021.52908.1399","DOIUrl":"https://doi.org/10.21608/EJH.2021.52908.1399","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"24 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89133381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-02DOI: 10.21608/EJH.2021.58480.1420
N. Morgan, Morsy Abouelgoud, Doaa A. Haiba, Heba Arakeep
{"title":"Comparative Study on the Effect of Injectable Platelet Rich Plasma versus its Topical Application in the Treatment of Thermal Burn in Adult Male Albino Rat: Histological and Immunohistochemical Study","authors":"N. Morgan, Morsy Abouelgoud, Doaa A. Haiba, Heba Arakeep","doi":"10.21608/EJH.2021.58480.1420","DOIUrl":"https://doi.org/10.21608/EJH.2021.58480.1420","url":null,"abstract":"","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"38 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85890996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-02-01DOI: 10.21608/EJH.2021.52300.1395
B. Mohamed, N. Fares, Neveen A Ashaat, Faten S. Abo-Zeid
Background: There has been a great interest in the toxicity of Aluminum (Al) due to its environmental wide distribution and every day usage. The key mechanisms of Al -induced toxicity in the liver are recognized as reactive oxygen species (ROS), development of free radicals, oxidative stress, and lipid peroxidation. L-carnitine is a conditionally important amino-acid (4-N-trimethylammonium-3-hydroxybutyric acid). By L-carnitine, long-chain fatty acids are taken into the mitochondria contributing to the metabolism of cellular energy. Also, it can enhance the antioxidant status by accelerating the free radicals removal from cells.Objective: The purpose of this report was to determine the possible detrimental impact of AlCl3 and to evaluate for the first time the possible potential hepato-protective effect of exogenous L-carnitine supplementation in ameliorating these possible deteriorations. Materials and methods: Thirty two rats were subdivided into equal four groups, Group I: Control rats, Group II: Rats treated with L-carnitine at a dose of 200 mg/kg. b.wt., Group III: Rats treated with Alcl3 at a dose of 100 mg/kg. b.wt., and Group IV: Rats treated with L-carnitine and Alcl3 (200 and 100 mg/kg. b.wt., respectively). All procedures of given materials to animals were orally once daily for one month. Results: The current investigation showed that Alcl3 ingestion caused an obvious hepatic deterioration evidenced by increased liver enzymes level and imbalance in oxidant/antioxidant status. This was accompanied by histological changes and increased Ki-67 and caspase-3 immunoreactivity. These effects were significantly improved by L-carnitine supplementation.Conclusion: These findings suggested that L-carnitine may have a protective effect against hepatic damage sustained by Alcl3 through its antioxidative property and its inhibitory effect on prolife ration and apoptosis.
背景:由于铝在环境中的广泛分布和日常使用，对其毒性的研究引起了人们的极大兴趣。Al诱导肝脏毒性的关键机制被认为是活性氧(ROS)、自由基的形成、氧化应激和脂质过氧化。左旋肉碱是一种条件重要的氨基酸(4- n -三甲基铵-3-羟基丁酸)。通过左旋肉碱，长链脂肪酸被带入线粒体，促进细胞能量的代谢。此外，它还能通过加速细胞中自由基的清除来增强抗氧化能力。目的:本报告的目的是确定AlCl3可能的有害影响，并首次评估外源性左旋肉碱补充在改善这些可能的恶化方面可能的潜在肝保护作用。材料与方法:将32只大鼠分为4组，ⅰ组为对照大鼠，ⅱ组为左旋肉碱给药200 mg/kg大鼠。b.wt。第三组:Alcl3给药100 mg/kg。b.wt。IV组:左旋肉碱和Alcl3(200和100 mg/kg)处理。b.wt。分别)。给药动物的所有程序均为每日口服1次，连续1个月。结果:目前的研究表明，摄入Alcl3导致肝脏明显恶化，表现为肝酶水平升高和氧化/抗氧化状态失衡。伴有组织学改变，Ki-67和caspase-3免疫反应性升高。补充左旋肉碱可显著改善这些效果。结论:提示左旋肉碱可能通过其抗氧化作用和抑制肝细胞增殖和凋亡作用，对Alcl3所致肝损伤具有保护作用。
{"title":"Biochemical, Histological, and Immunohistochemical Changes Associated with Alcl3- Induced Hepatic Injury in Rats: Protective Effects of L-carnitine","authors":"B. Mohamed, N. Fares, Neveen A Ashaat, Faten S. Abo-Zeid","doi":"10.21608/EJH.2021.52300.1395","DOIUrl":"https://doi.org/10.21608/EJH.2021.52300.1395","url":null,"abstract":"Background: There has been a great interest in the toxicity of Aluminum (Al) due to its environmental wide distribution and every day usage. The key mechanisms of Al -induced toxicity in the liver are recognized as reactive oxygen species (ROS), development of free radicals, oxidative stress, and lipid peroxidation. L-carnitine is a conditionally important amino-acid (4-N-trimethylammonium-3-hydroxybutyric acid). By L-carnitine, long-chain fatty acids are taken into the mitochondria contributing to the metabolism of cellular energy. Also, it can enhance the antioxidant status by accelerating the free radicals removal from cells.Objective: The purpose of this report was to determine the possible detrimental impact of AlCl3 and to evaluate for the first time the possible potential hepato-protective effect of exogenous L-carnitine supplementation in ameliorating these possible deteriorations. Materials and methods: Thirty two rats were subdivided into equal four groups, Group I: Control rats, Group II: Rats treated with L-carnitine at a dose of 200 mg/kg. b.wt., Group III: Rats treated with Alcl3 at a dose of 100 mg/kg. b.wt., and Group IV: Rats treated with L-carnitine and Alcl3 (200 and 100 mg/kg. b.wt., respectively). All procedures of given materials to animals were orally once daily for one month. Results: The current investigation showed that Alcl3 ingestion caused an obvious hepatic deterioration evidenced by increased liver enzymes level and imbalance in oxidant/antioxidant status. This was accompanied by histological changes and increased Ki-67 and caspase-3 immunoreactivity. These effects were significantly improved by L-carnitine supplementation.Conclusion: These findings suggested that L-carnitine may have a protective effect against hepatic damage sustained by Alcl3 through its antioxidative property and its inhibitory effect on prolife ration and apoptosis.","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"50 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80967918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-01-31DOI: 10.21608/EJH.2021.52901.1397
Reem Mohamed, R. Nabil, Y. A. Elzankalony, A. Zaki, S. Elwan
Purpose: To correlate the clinical data to the histopathological characteristics of lacrimal sac and bone specimens in adult patients undergoing indicated external transcutaneous dacryocystorhinostomy surgery (DCR) for primary acquired nasolacrimal duct obstruction (PANDO) in order to determine the important clinical parameters that may necessitate selective lacrimal biopsy in certain situations.Methods: This is non-comparative, non-controlled descriptive case series study with histopathological correlation. Lacrimal sac and bone specimens for each case were collected during DCR from consecutive patients with PANDO presenting to the outpatient clinic of “Ain Shams University” hospitals, then sent for histopathological examination.Results: Fifty-one lacrimal specimens were obtained from a total of 49 consecutive patients who underwent external DCR for clinical PANDO at the time interval from March 2018 to March 2020 at “Department of Ophthalmology, Ain Shams University” operating theatre. The mean patients' age was 44.82± 13.63 years (range 21- 75). Among the 49 patients recruited, 6 (12.2%) were males and 43 (87.8%) were females. Non -specific lacrimal sac pathology was present in all 51 samples (3.9% acute inflammation and 96.1% chronic non-specific inflammation). Of the chronic non-specific inflammation specimens, mild degree of inflammation was seen in 40.8%, 44.9% showed moderate chronic inflammation, whereas only 14.3% showed severe inflammatory changes. The only two clinical parameters that were strongly correlated with the severity of inflammation are the intraoperative appearance of the sac and the presence of a lacrimal fistula with P-value (
{"title":"Clinical -to- Pathological Correlation of Lacrimal Sac Specimens Obtained During Dacryocystorhinostomy Surgery","authors":"Reem Mohamed, R. Nabil, Y. A. Elzankalony, A. Zaki, S. Elwan","doi":"10.21608/EJH.2021.52901.1397","DOIUrl":"https://doi.org/10.21608/EJH.2021.52901.1397","url":null,"abstract":"Purpose: To correlate the clinical data to the histopathological characteristics of lacrimal sac and bone specimens in adult patients undergoing indicated external transcutaneous dacryocystorhinostomy surgery (DCR) for primary acquired nasolacrimal duct obstruction (PANDO) in order to determine the important clinical parameters that may necessitate selective lacrimal biopsy in certain situations.Methods: This is non-comparative, non-controlled descriptive case series study with histopathological correlation. Lacrimal sac and bone specimens for each case were collected during DCR from consecutive patients with PANDO presenting to the outpatient clinic of “Ain Shams University” hospitals, then sent for histopathological examination.Results: Fifty-one lacrimal specimens were obtained from a total of 49 consecutive patients who underwent external DCR for clinical PANDO at the time interval from March 2018 to March 2020 at “Department of Ophthalmology, Ain Shams University” operating theatre. The mean patients' age was 44.82± 13.63 years (range 21- 75). Among the 49 patients recruited, 6 (12.2%) were males and 43 (87.8%) were females. Non -specific lacrimal sac pathology was present in all 51 samples (3.9% acute inflammation and 96.1% chronic non-specific inflammation). Of the chronic non-specific inflammation specimens, mild degree of inflammation was seen in 40.8%, 44.9% showed moderate chronic inflammation, whereas only 14.3% showed severe inflammatory changes. The only two clinical parameters that were strongly correlated with the severity of inflammation are the intraoperative appearance of the sac and the presence of a lacrimal fistula with P-value (","PeriodicalId":22420,"journal":{"name":"the egyptian journal of histology","volume":"9 1","pages":"0-0"},"PeriodicalIF":0.0,"publicationDate":"2021-01-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79984588","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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