Pub Date : 2021-06-06DOI: 10.21608/EJCHEM.2021.77940.3833
Afnan N. Abdrabou, Sara M. Radwan, Reham El shimy, H. E. Mesallamy
Background: The extracellular signal-regulated kinase (ERK) pathway is a key signaling pathway involved in the regulation of normal cell proliferation, survival and differentiation. However, aberrant regulations of the ERK pathway contribute to cancer and other human diseases. Objective: This study was designed to investigate the role of some ERK pathway effectors such as the connector enhancer of kinase suppressor of Ras1 (CNK1), Ephrin B1, G protein-coupled receptor 19 (GPR19) and SMAD ubiquitination regulatory factor 1 (SMURF1) in breast cancer (BC) diagnosis and metastasis risk prediction. Methods: The study involved 50 (ERPRHer2=6, ERPRHer2=11, ERPRHER2=8, ERPRHer2=25) newly diagnosed BC patients, 15 chemotherapy resistant BC patients, 15 benign breast tumor patients and 10 controls. All total 65 BC patients (including the chemotherapy resistant group) were subdivided into two groups: metastatic BC (17 patients), and nonmetastatic BC group (48 patients). CNK1, Ephrin B1, GPR19 and SMURF1 serum levels were analyzed using ELISA. Results: The study revealed significantly higher serum levels of CNK1, Ephrin B1, GPR19 and SMURF1 in all malignant groups (ERPRHer2, ERPRHer2, ERPRHER2, ERPRHer2), as well as a significant elevation in the chemotherapy resistant BC group as compared to non-resistant group (P < 0.001). They also revealed excellent value for de novo BC diagnosis and metastasis prediction. Conclusion: CNK1, Ephrin B1, GPR19 and SMURF1 may be considered as novel biomarkers for BC diagnosis and prediction of metastasis risk.
{"title":"Role of CNK1, Ephrin B1, GPR19 and SMURF1 in breast cancer early diagnosis, metastasis and drug resistance","authors":"Afnan N. Abdrabou, Sara M. Radwan, Reham El shimy, H. E. Mesallamy","doi":"10.21608/EJCHEM.2021.77940.3833","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.77940.3833","url":null,"abstract":"Background: The extracellular signal-regulated kinase (ERK) pathway is a key signaling pathway involved in the regulation of normal cell proliferation, survival and differentiation. However, aberrant regulations of the ERK pathway contribute to cancer and other human diseases. Objective: This study was designed to investigate the role of some ERK pathway effectors such as the connector enhancer of kinase suppressor of Ras1 (CNK1), Ephrin B1, G protein-coupled receptor 19 (GPR19) and SMAD ubiquitination regulatory factor 1 (SMURF1) in breast cancer (BC) diagnosis and metastasis risk prediction. Methods: The study involved 50 (ERPRHer2=6, ERPRHer2=11, ERPRHER2=8, ERPRHer2=25) newly diagnosed BC patients, 15 chemotherapy resistant BC patients, 15 benign breast tumor patients and 10 controls. All total 65 BC patients (including the chemotherapy resistant group) were subdivided into two groups: metastatic BC (17 patients), and nonmetastatic BC group (48 patients). CNK1, Ephrin B1, GPR19 and SMURF1 serum levels were analyzed using ELISA. Results: The study revealed significantly higher serum levels of CNK1, Ephrin B1, GPR19 and SMURF1 in all malignant groups (ERPRHer2, ERPRHer2, ERPRHER2, ERPRHer2), as well as a significant elevation in the chemotherapy resistant BC group as compared to non-resistant group (P < 0.001). They also revealed excellent value for de novo BC diagnosis and metastasis prediction. Conclusion: CNK1, Ephrin B1, GPR19 and SMURF1 may be considered as novel biomarkers for BC diagnosis and prediction of metastasis risk.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83011922","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-05DOI: 10.21608/EJCHEM.2021.78216.3827
M. Abid, Fathil R. Hafith, Taghreed M. Musa, B. F. Abbas
The present work involves the synthesis and characterization of cobalt (II), nickel (II) and copper (II) complexes derived from (1:1:1) mole ratios of coumarine-oxime:1,10-phenanthroline:metal ions with respect to the continuous variation method of Job via spectroscopic studies. The isolated metal complexes were characterized with their ligands of 3-acetoxime-coumarine by elemental analyses, FT-IR, EI-MS and NMR spectra. The flame atomic absorption spectroscopy, molar conductivity in DMF and magnetic moment measurements were also employed to determine the supposed molecular weights and their geometry. Furthermore the gravimetric thermal analysis (TG-DTA) was estimated for copper(II) and nickel(II) complexes and the observed data form weight loss percents confirmed the suggested chemical formulas and structures of complexes. The results observed from UV-Visible spectra and elemental analyses together with mass spectra confirmed the octahedral geometry around the cobalt(II) and copper(II) ions whereas the diamagnetic complex of nickel(II) was square-planner in [Ni(Phen)(L)]Cl2 formula. As well as the biological activities of complexes solutions were tested against two types of bacteria and the inhibition zones data proved that all solutions were active compared with standard drugs of 10 ppm concentrations.
{"title":"Synthesis, Characterization and Biological Activity Study of Cobalt(II), Nickel(II) and Copper(II) Complexes Derived from Mixed Bi dentate Ligands of Oxime and Phenanthroline11","authors":"M. Abid, Fathil R. Hafith, Taghreed M. Musa, B. F. Abbas","doi":"10.21608/EJCHEM.2021.78216.3827","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.78216.3827","url":null,"abstract":"The present work involves the synthesis and characterization of cobalt (II), nickel (II) and copper (II) complexes derived from (1:1:1) mole ratios of coumarine-oxime:1,10-phenanthroline:metal ions with respect to the continuous variation method of Job via spectroscopic studies. The isolated metal complexes were characterized with their ligands of 3-acetoxime-coumarine by elemental analyses, FT-IR, EI-MS and NMR spectra. The flame atomic absorption spectroscopy, molar conductivity in DMF and magnetic moment measurements were also employed to determine the supposed molecular weights and their geometry. Furthermore the gravimetric thermal analysis (TG-DTA) was estimated for copper(II) and nickel(II) complexes and the observed data form weight loss percents confirmed the suggested chemical formulas and structures of complexes. The results observed from UV-Visible spectra and elemental analyses together with mass spectra confirmed the octahedral geometry around the cobalt(II) and copper(II) ions whereas the diamagnetic complex of nickel(II) was square-planner in [Ni(Phen)(L)]Cl2 formula. As well as the biological activities of complexes solutions were tested against two types of bacteria and the inhibition zones data proved that all solutions were active compared with standard drugs of 10 ppm concentrations.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82175751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-05DOI: 10.21608/EJCHEM.2021.78214.3825
Sumaya M. Salih, Hameed M. Alkubaisi, F. L. Faraj
{"title":"Synthesis and Characterization of Novel Pyrazole Derivatives from 4-Florophenylhydrazine and Study Their Cytotoxicity as Anti-Cancer Agent 11","authors":"Sumaya M. Salih, Hameed M. Alkubaisi, F. L. Faraj","doi":"10.21608/EJCHEM.2021.78214.3825","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.78214.3825","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83427575","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-05DOI: 10.21608/EJCHEM.2021.78215.3826
A. Jabbar, M. Al-Jibouri, A. H. Ismail
{"title":"Synthesis and Structural Studies of Transition Metals Complexes with Poly dentate Azo dye ligand Derived from Coumarine11","authors":"A. Jabbar, M. Al-Jibouri, A. H. Ismail","doi":"10.21608/EJCHEM.2021.78215.3826","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.78215.3826","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73317470","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-05DOI: 10.21608/EJCHEM.2021.73699.3641
Yasser Fakri Mustafa, E. Mohammed, R. Khalil
Despite their rarity and structural complexity, natural and synthetic biscoumarins have polarized much attention from investigators particularly due to their characteristic activity as anticoagulant agents. In this work, a panel of twelve functionalized biscoumarins was synthesized in two schematic steps; the first one started by condensing various phenol-based derivatives with malonic acid via a Pechmann-type reaction yielding alkyl-substituted 4-hydroxycoumarins herein symbolized as (E1-E12). The latter compounds were undergone a self-coupling under the influence of methylene iodide to afford the target functionalized biscoumarins, which were symbolized as (EY1-EY12). The potential of the synthesized biscoumarins as anticoagulant applicants was investigated in vivo using rabbit as an animal model. The employed assay was the prothrombin time that was monitored after three and five days of the last oral treatment. The results gathered from this test revealed that the synthesized biscoumarins have a promising anticoagulant activity compared with warfarin as a standard anticoagulant drug, with privileged influence contributed to those substituted at position 7 of the coumarin framework. The authors concluded that the substitution of an alkyl group at that position of the coumarin monomer may intensify the anticoagulant activity of the prepared biscoumarins. Also, this intensity was directly proportionated to the increase in the molecular weight of this alkyl group. Accordingly, the synthesized biscoumarins possessing this property would provide an efficient base for synthesizing new compounds, which have a promising anticoagulant effect.
{"title":"Synthesis, characterization, and anticoagulant activity of new functionalized biscoumarins","authors":"Yasser Fakri Mustafa, E. Mohammed, R. Khalil","doi":"10.21608/EJCHEM.2021.73699.3641","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.73699.3641","url":null,"abstract":"Despite their rarity and structural complexity, natural and synthetic biscoumarins have polarized much attention from investigators particularly due to their characteristic activity as anticoagulant agents. In this work, a panel of twelve functionalized biscoumarins was synthesized in two schematic steps; the first one started by condensing various phenol-based derivatives with malonic acid via a Pechmann-type reaction yielding alkyl-substituted 4-hydroxycoumarins herein symbolized as (E1-E12). The latter compounds were undergone a self-coupling under the influence of methylene iodide to afford the target functionalized biscoumarins, which were symbolized as (EY1-EY12). The potential of the synthesized biscoumarins as anticoagulant applicants was investigated in vivo using rabbit as an animal model. The employed assay was the prothrombin time that was monitored after three and five days of the last oral treatment. The results gathered from this test revealed that the synthesized biscoumarins have a promising anticoagulant activity compared with warfarin as a standard anticoagulant drug, with privileged influence contributed to those substituted at position 7 of the coumarin framework. The authors concluded that the substitution of an alkyl group at that position of the coumarin monomer may intensify the anticoagulant activity of the prepared biscoumarins. Also, this intensity was directly proportionated to the increase in the molecular weight of this alkyl group. Accordingly, the synthesized biscoumarins possessing this property would provide an efficient base for synthesizing new compounds, which have a promising anticoagulant effect.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76832358","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.21608/EJCHEM.2021.73818.3650
R. Aldujaili, A. Alhasan
In this work new different hetero cyclic derivatives were synthesized that which including β-Lactam, teterazole and also thiazole rings.The starting material is 2-amino-6-methoxy-Benzothiazole. All these reactions follow by (TLC) and Measurement melting points for some of these derivatives. The compounds identified by FT-IR and some of them by 1H-NMR and 13C-NMR spectra., The prepared benzothiazole derivatives in this study gave good results through appearance of new bands and disapearance of other bands in formatted compounds that gave first data to formation benzothiazole derivative , while second technique represented by resonance spectra that gave also good results for formatted benzothiazole derivative.m in addition to flowing of all reactions by paper chromatography.
{"title":"Preparation and Characterization of some new Benzothiazole-Heterocyclic Derivatives","authors":"R. Aldujaili, A. Alhasan","doi":"10.21608/EJCHEM.2021.73818.3650","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.73818.3650","url":null,"abstract":"In this work new different hetero cyclic derivatives were synthesized that which including β-Lactam, teterazole and also thiazole rings.The starting material is 2-amino-6-methoxy-Benzothiazole. All these reactions follow by (TLC) and Measurement melting points for some of these derivatives. The compounds identified by FT-IR and some of them by 1H-NMR and 13C-NMR spectra., The prepared benzothiazole derivatives in this study gave good results through appearance of new bands and disapearance of other bands in formatted compounds that gave first data to formation benzothiazole derivative , while second technique represented by resonance spectra that gave also good results for formatted benzothiazole derivative.m in addition to flowing of all reactions by paper chromatography.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91539866","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.21608/EJCHEM.2021.50081.3057
A. Al-Sabawi, Hyffaa Y. Hussien, Abdulkhalik S. Alkazzaz
The prediction of Thermal Isomerization temperatures (IT) of benzocyclobutenes is useful for their applications in synthesis and polymerization. In this study, ITs were predicted by equations formulated from the hardness, of the products transition states or the difference between the hardness of product and transition state. Also, ITs predicted from the orbital energies of the σ, σ*, π and π* orbitals of the benzocyclobutenes.
{"title":"Prediction of Thermal Isomerization Temperatures of Substituted Benzocyclobutenes to o- Quinodimethanes Using Hardness, Polarizability and energies of σ, σ* and π* orbitals.","authors":"A. Al-Sabawi, Hyffaa Y. Hussien, Abdulkhalik S. Alkazzaz","doi":"10.21608/EJCHEM.2021.50081.3057","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.50081.3057","url":null,"abstract":"The prediction of Thermal Isomerization temperatures (IT) of benzocyclobutenes is useful for their applications in synthesis and polymerization. In this study, ITs were predicted by equations formulated from the hardness, of the products transition states or the difference between the hardness of product and transition state. Also, ITs predicted from the orbital energies of the σ, σ*, π and π* orbitals of the benzocyclobutenes.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81422027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-06-01DOI: 10.21608/EJCHEM.2021.76688.3788
Alaadin E. El-Haddad, E. Deeb, A. Amer, Amr M. Saadeldeen, Fakher M. Ahmed, M. Salem, H. Taha
Morus is a plant genus of the family Moraceae, most of which is used as a decoction in traditional medicines for the treatment of cough, bronchitis, pulmonary diseases and reduces the plasma sugar level. Many studies in Morus phytochemistry have contributed to the discovery of Diels-Alder-type adducts, arylbenzofurans, and flavonoids with antioxidant, antihyperglycemic, antihypertensive, antihyperlipidemic, and anti-inflammatory activities. The purpose of this article was to offers an account of the updated knowledge on the phytochemicals and pharmacological activities of these compounds. This review will help to fully understanding the efficacy and pave the way for further explore the comprehensive use of Morus. We conclude that Morus needs further reports in the identification of bioactive constituents and strengthen the claim of folk medicines.
{"title":"Bioactive Phytoconstituents of Morus Plants exhibiting Numerous Therapeutic Activities","authors":"Alaadin E. El-Haddad, E. Deeb, A. Amer, Amr M. Saadeldeen, Fakher M. Ahmed, M. Salem, H. Taha","doi":"10.21608/EJCHEM.2021.76688.3788","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.76688.3788","url":null,"abstract":"Morus is a plant genus of the family Moraceae, most of which is used as a decoction in traditional medicines for the treatment of cough, bronchitis, pulmonary diseases and reduces the plasma sugar level. Many studies in Morus phytochemistry have contributed to the discovery of Diels-Alder-type adducts, arylbenzofurans, and flavonoids with antioxidant, antihyperglycemic, antihypertensive, antihyperlipidemic, and anti-inflammatory activities. The purpose of this article was to offers an account of the updated knowledge on the phytochemicals and pharmacological activities of these compounds. This review will help to fully understanding the efficacy and pave the way for further explore the comprehensive use of Morus. We conclude that Morus needs further reports in the identification of bioactive constituents and strengthen the claim of folk medicines.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90839203","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-31DOI: 10.21608/EJCHEM.2021.69217.3516
Wafaa B. Elsharkawy
Abstract. Iodine-doped Poly (Ethyl Methacrylate) composites have been prepared using casting method. Global TSDC of the composite samples has been investigated using TSDC-TS technique. It is found that, global TSDC spectra of pure PEMA are characterized by two relaxations. The first relaxation which is observed as a shoulder in the temperature range 324-333 K is attributed to the motion of side group and named -relaxation. Whereas, the second relaxation is observed in the glass temperature range of PEMA at Tm= 347 K and named as dipolar relaxation, i.e., -relaxation. On doping with iodine, a new relaxation peak has been obtained at high temperatures ~ 397-409 K, and named as space charge relaxation, i.e., -relaxation. Complex TSDC spectra of PEMA-Iodine composites have been resolved into its elementary peaks using TS technique. These elementary peaks have been used to construct relaxation map (RM) of all samples using Eyring transformation. The existence of compensation phenomenon for all samples is also verified and the coordinates of each compensation point have been estimated. These coordinates are used to calculate the density of disorder (DOD) and thermal expansion coefficient of the samples. The thermodynamic parameters of the samples, such as, enthalpy, entropy and Gibbs free energy have been calculated at different poling temperatures.
{"title":"Rate Theory and Relaxation Map Analysis of Iodine-Doped Poly(Ethyl Methacrylate) composite films using Thermally Stimulated Depolarization Current-Thermal Sampling (TSDC-TS) Technique","authors":"Wafaa B. Elsharkawy","doi":"10.21608/EJCHEM.2021.69217.3516","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.69217.3516","url":null,"abstract":"Abstract. Iodine-doped Poly (Ethyl Methacrylate) composites have been prepared using casting method. Global TSDC of the composite samples has been investigated using TSDC-TS technique. It is found that, global TSDC spectra of pure PEMA are characterized by two relaxations. The first relaxation which is observed as a shoulder in the temperature range 324-333 K is attributed to the motion of side group and named -relaxation. Whereas, the second relaxation is observed in the glass temperature range of PEMA at Tm= 347 K and named as dipolar relaxation, i.e., -relaxation. On doping with iodine, a new relaxation peak has been obtained at high temperatures ~ 397-409 K, and named as space charge relaxation, i.e., -relaxation. Complex TSDC spectra of PEMA-Iodine composites have been resolved into its elementary peaks using TS technique. These elementary peaks have been used to construct relaxation map (RM) of all samples using Eyring transformation. The existence of compensation phenomenon for all samples is also verified and the coordinates of each compensation point have been estimated. These coordinates are used to calculate the density of disorder (DOD) and thermal expansion coefficient of the samples. The thermodynamic parameters of the samples, such as, enthalpy, entropy and Gibbs free energy have been calculated at different poling temperatures.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91091291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-05-30DOI: 10.21608/EJCHEM.2021.70308.3549
D. Beltagy, N. Abdo, N. Samak, Gihan M. El-khodary, K. Abdel-Aziz, M. Mona
Silver nanoparticles (AgNPs) have wide applications. Production of AgNPs can be occurred through different method chemical, physical, and green methods. The most popular methods are chemical approaches. Marine organisms exhibit a wide range of bioactivity. The present study was designed to establish the biosynthesis of silver nanoparticles from marine crustacean extract of the hard and soft parts of male and female E. massavensis. The microstructure, morphology and optical absorption properties of the nanoparticles were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and UV-visible spectroscopy. The formation of silver nanoparticles was confirmed by Uv-Vis absorption and the spectra were observed plasmon bands between 441.79–462.74 nm. XRD results show that the nanoparticles are crystalline in nature. SEM images detected the quasi-spherical AgNPs morphological shape. Silver nanoparticles from marine crustacean extract of the hard part of male E. massavensis (HM4) showed the best results in morphology and particle size. Evaluation of the cytotoxicity of AgNPs (HM4) on different cancer cell lines antiviral, anti-microbial, anti-diabetic, anti-arthritic, anti-aging and anti-inflammatory properties were assessed. AgNPs characterization may be introduced a promising applications in medical aspects.
{"title":"Beneficial Bioapplications of Silver Nanoparticles Synthesized by a Marine Crustacean (Erugosquilla massavensis)","authors":"D. Beltagy, N. Abdo, N. Samak, Gihan M. El-khodary, K. Abdel-Aziz, M. Mona","doi":"10.21608/EJCHEM.2021.70308.3549","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.70308.3549","url":null,"abstract":"Silver nanoparticles (AgNPs) have wide applications. Production of AgNPs can be occurred through different method chemical, physical, and green methods. The most popular methods are chemical approaches. Marine organisms exhibit a wide range of bioactivity. The present study was designed to establish the biosynthesis of silver nanoparticles from marine crustacean extract of the hard and soft parts of male and female E. massavensis. The microstructure, morphology and optical absorption properties of the nanoparticles were characterized by X-ray diffraction (XRD), scanning electron microscopy (SEM) and UV-visible spectroscopy. The formation of silver nanoparticles was confirmed by Uv-Vis absorption and the spectra were observed plasmon bands between 441.79–462.74 nm. XRD results show that the nanoparticles are crystalline in nature. SEM images detected the quasi-spherical AgNPs morphological shape. Silver nanoparticles from marine crustacean extract of the hard part of male E. massavensis (HM4) showed the best results in morphology and particle size. Evaluation of the cytotoxicity of AgNPs (HM4) on different cancer cell lines antiviral, anti-microbial, anti-diabetic, anti-arthritic, anti-aging and anti-inflammatory properties were assessed. AgNPs characterization may be introduced a promising applications in medical aspects.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90200824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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