Pub Date : 2021-04-27DOI: 10.21608/EJCHEM.2021.73023.3618
A. Abdel-Aziz, Mona Abdel-Motagaly, M. A. Abdallah, Rasha Shaaban, N. S. Osman, N. Elwan
Polyphenols rich plants can be used to reduce health disorder resulting from cancer and infectious diseases. Methodology: Different solvent extracts of Ceiba insignis leaves were evaluated for their in vitro cytotoxic, antimicrobial, and antioxidant activities, while their chemical profiles were investigated via high‐performance liquid-chromatography (HPLC) -fingerprint analyses. Results: Showed that methanol, butanol, and dichloromethane extracts of Ceiba insignis leaves exhibited a moderate cytotoxicity against HepG2 with IC50 values of 98.54, 75.38, 40.71 μg/ml respectiviely, while petroleum ether and water exhibited weak activity with IC50 values of 118.15 and 170.03 μg/ml respectively and very weak activity was recorded with ethyl acetate extract with IC50 value of 924.05μg. Moreover, methanol, dichloromethane, petroleum ether, and ethyl acetate exhibited strong antimicrobial activities with inhibition zones (20-25 mm), (15-30 mm), (14-16 mm), and (16-28 mm) respectively, while butanol and water exhibited low to moderate activity with inhibition zones (0-18 mm), and (0-16 mm) respectively. On the other side, strong DPPH antioxidant scavenging activity was recorded within petroleum ether extract with IC50 (24.72 μg/ml), while the least antioxidant activity was recorded within ethyl acetate with IC50 (97.50 μg/ml). HPLC fingerprint analyses revealed the presence of major compounds; syringic acid in dichloromethane extract, gallic acid, chlorogenic acid & syringic acid in ethyl acetate extract, and naringenin & gallic acid in methanol, butanol and water extracts, this finding provides an insight into the usage of the tested species as a source of naturally occurring antioxidant, cytotoxic and antimicrobial agents.
{"title":"In vitro Cytotoxicity, Antimicrobial, Antioxidant Activities and HPLC Finger Print Analyses of the Extracts of Ceiba insignis Leaves Growing in Egypt","authors":"A. Abdel-Aziz, Mona Abdel-Motagaly, M. A. Abdallah, Rasha Shaaban, N. S. Osman, N. Elwan","doi":"10.21608/EJCHEM.2021.73023.3618","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.73023.3618","url":null,"abstract":"Polyphenols rich plants can be used to reduce health disorder resulting from cancer and infectious diseases. Methodology: Different solvent extracts of Ceiba insignis leaves were evaluated for their in vitro cytotoxic, antimicrobial, and antioxidant activities, while their chemical profiles were investigated via high‐performance liquid-chromatography (HPLC) -fingerprint analyses. Results: Showed that methanol, butanol, and dichloromethane extracts of Ceiba insignis leaves exhibited a moderate cytotoxicity against HepG2 with IC50 values of 98.54, 75.38, 40.71 μg/ml respectiviely, while petroleum ether and water exhibited weak activity with IC50 values of 118.15 and 170.03 μg/ml respectively and very weak activity was recorded with ethyl acetate extract with IC50 value of 924.05μg. Moreover, methanol, dichloromethane, petroleum ether, and ethyl acetate exhibited strong antimicrobial activities with inhibition zones (20-25 mm), (15-30 mm), (14-16 mm), and (16-28 mm) respectively, while butanol and water exhibited low to moderate activity with inhibition zones (0-18 mm), and (0-16 mm) respectively. On the other side, strong DPPH antioxidant scavenging activity was recorded within petroleum ether extract with IC50 (24.72 μg/ml), while the least antioxidant activity was recorded within ethyl acetate with IC50 (97.50 μg/ml). HPLC fingerprint analyses revealed the presence of major compounds; syringic acid in dichloromethane extract, gallic acid, chlorogenic acid & syringic acid in ethyl acetate extract, and naringenin & gallic acid in methanol, butanol and water extracts, this finding provides an insight into the usage of the tested species as a source of naturally occurring antioxidant, cytotoxic and antimicrobial agents.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74667913","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.21608/EJCHEM.2021.69667.3539
O. El-Gammal, Hanna El-Boraey, Azza A. Serag El-Din
{"title":"Design, Spectroscopic Characterization, Thermal, 3D Molecular Modeling, XRD and in Vitro Antioxidant and Antimicrobial Screening of Novel N2O2 Tetradentate Schiff’s Base Metal Complexes","authors":"O. El-Gammal, Hanna El-Boraey, Azza A. Serag El-Din","doi":"10.21608/EJCHEM.2021.69667.3539","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.69667.3539","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74208126","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-27DOI: 10.21608/EJCHEM.2021.71817.3578
Eman A. Khalil, W. Mahmoud, M. El-Dessouky, G. Mohamed
The new bidentate Schiff base ligand (L) named N1-(diphenylmethylene)naphthalene-1,8-diamine was prepared by the condensation reaction of benzophenone and 1,8-naphthylenediamine. The complexes with Mn(II), Ni(II), Zn(II), La(III), Er(III), and Yb(III) metal ions were prepared and characterized by using elemental analyses (C, H, N and M), FT-IR, 1H NMR, molar conductivity, magnetic moment, UV-Vis, mass and scanning electron microscope (SEM). The temperatures of decomposition of the Schiff base ligand and metal complexes were investigated using thermal analyses. The metal complexes were found to have the formulae [M(L)(H2O)3Cl]Cl.nH2O (M = Mn(II) (n = 4); Ni(II) (n = 2))], [Zn(L)(H2O)2Cl2] and [M(L)(H2O)2Cl2]Cl (M = La(III), Er(III) and Yb(III)) according to the elemental analyses data. The geometrical structure of all complexes was found to be octahedral. The molar conductivity of the complexes in DMF indicated the electrolytic nature of all complexes except Zn(II) complex was non-electrolyte. From the spectroscopic data, the Schiff base ligand acts as NNbidentate ligand. The biological and anticancer activities of the Schiff base ligand and its complexes were investigated against two bacterial strains, two fungal strains and breast cancer cell line (MCF-7). Docking studies were performed to study the possible interaction between the Schiff base ligand with the active sites of the 3HB5 and 5JPE receptors.
{"title":"Synthesis, Spectral, Thermal and Biological Studies of Some Transition and Inner Transition Schiff base Metal Complexes","authors":"Eman A. Khalil, W. Mahmoud, M. El-Dessouky, G. Mohamed","doi":"10.21608/EJCHEM.2021.71817.3578","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.71817.3578","url":null,"abstract":"The new bidentate Schiff base ligand (L) named N1-(diphenylmethylene)naphthalene-1,8-diamine was prepared by the condensation reaction of benzophenone and 1,8-naphthylenediamine. The complexes with Mn(II), Ni(II), Zn(II), La(III), Er(III), and Yb(III) metal ions were prepared and characterized by using elemental analyses (C, H, N and M), FT-IR, 1H NMR, molar conductivity, magnetic moment, UV-Vis, mass and scanning electron microscope (SEM). The temperatures of decomposition of the Schiff base ligand and metal complexes were investigated using thermal analyses. The metal complexes were found to have the formulae [M(L)(H2O)3Cl]Cl.nH2O (M = Mn(II) (n = 4); Ni(II) (n = 2))], [Zn(L)(H2O)2Cl2] and [M(L)(H2O)2Cl2]Cl (M = La(III), Er(III) and Yb(III)) according to the elemental analyses data. The geometrical structure of all complexes was found to be octahedral. The molar conductivity of the complexes in DMF indicated the electrolytic nature of all complexes except Zn(II) complex was non-electrolyte. From the spectroscopic data, the Schiff base ligand acts as NNbidentate ligand. The biological and anticancer activities of the Schiff base ligand and its complexes were investigated against two bacterial strains, two fungal strains and breast cancer cell line (MCF-7). Docking studies were performed to study the possible interaction between the Schiff base ligand with the active sites of the 3HB5 and 5JPE receptors.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80754962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-25DOI: 10.21608/EJCHEM.2021.70105.3585
M. Mohamed, A. Soliman, Mohamed Abbas, Hisham Abd el-lateaf, A. Ismael
{"title":"Comparative study for physico - chemical characteristics of crude Moringa Peregrina , Terminalia bellerica and Tiger nut oils","authors":"M. Mohamed, A. Soliman, Mohamed Abbas, Hisham Abd el-lateaf, A. Ismael","doi":"10.21608/EJCHEM.2021.70105.3585","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.70105.3585","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90057715","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-25DOI: 10.21608/EJCHEM.2021.72328.3592
A. Draz, E. Shamso, H. Hosni, S. Kawashty, S. Hussein
{"title":"Comparative study of Oxalis L. species growing wild in Egypt: GC-MS analysis and chemosystematic significance","authors":"A. Draz, E. Shamso, H. Hosni, S. Kawashty, S. Hussein","doi":"10.21608/EJCHEM.2021.72328.3592","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.72328.3592","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84346347","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-25DOI: 10.21608/EJCHEM.2021.68614.3509
J. Jamur, S. Abbas, Takleef Sallal
{"title":"Indirect spectrophotometric determination of Mebendazole using n-bromosuccinimide as an oxidant and tartarazine dye as analytical reagent","authors":"J. Jamur, S. Abbas, Takleef Sallal","doi":"10.21608/EJCHEM.2021.68614.3509","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.68614.3509","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85731967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-25DOI: 10.21608/EJCHEM.2021.44696.2908
Sameaa J. Khammas, S. Yosef, T. A. Mahmood, W. Mahmood, Shahad Taher, Muna Abass Hadi
{"title":"Synthesis and characterization of chelating phenolic polymers containing Metoclopramide hydrochloride drugs","authors":"Sameaa J. Khammas, S. Yosef, T. A. Mahmood, W. Mahmood, Shahad Taher, Muna Abass Hadi","doi":"10.21608/EJCHEM.2021.44696.2908","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.44696.2908","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76812827","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-23DOI: 10.21608/EJCHEM.2021.64886.3390
S. A. Dadoosh, M. Thani, A. Abdullah, A. S. Fahad, Y. Fahad
{"title":"Development of an Ecological-friendly Method for Dexamethasone Determination and Cloud Point Extraction in pharmaceutical formulations using Schiff Base Reaction","authors":"S. A. Dadoosh, M. Thani, A. Abdullah, A. S. Fahad, Y. Fahad","doi":"10.21608/EJCHEM.2021.64886.3390","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.64886.3390","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73434691","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-23DOI: 10.21608/EJCHEM.2021.68873.3508
Yasser Fakri Mustafa, R. Khalil, E. Mohammed
Compounds having their chemical structure based on coumarin framework have enticed much research concern not only because of the variance structural characteristic but also the pluralism of the bioactivities. In this report, four derivatives of 7halo-4-coumarinylacetic acid referred to as RY1-RY4 were synthesized, and their chemical backbones were confirmed via the employed spectrophotometers. The pharmacokinetic profiles of the synthesized halocoumarins were inspected in silico using a free online software named the pre-ADMET program. The potential of the synthesized halocoumarins as antitumor applicants was evaluated utilizing 5-fluorouracil as a reference drug and the well-authenticated protocol based on the MTT as a visible indicator against eight standard tumor-cell lines. The outcomes acquired from this assessment indicated that the synthesized halocoumarins, except RY1, have less impact as antitumor agents comparing with the standard drug. Also, the halocoumarins revealed roughly the same fashion of activity versus the test cell lines with the greatest inhibitory influence reported against MCF-7 and HeLa. From the calculated pharmacokinetic data and outcomes exhibited from antitumor assessment, the authors concluded that the synthesized halocoumarins, particularly RY1, offered potential applicants as antitumor agents with broad-ranged activity. Besides, the compounds RY1 and RY2 may provide highly valuable scaffolds for synthesizing agents with a powerful antitumor activity versus the breast and cervical cancer phenotypes.
{"title":"Synthesis and antitumor potential of new 7-halocoumarin-4-acetic acid derivatives","authors":"Yasser Fakri Mustafa, R. Khalil, E. Mohammed","doi":"10.21608/EJCHEM.2021.68873.3508","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.68873.3508","url":null,"abstract":"Compounds having their chemical structure based on coumarin framework have enticed much research concern not only because of the variance structural characteristic but also the pluralism of the bioactivities. In this report, four derivatives of 7halo-4-coumarinylacetic acid referred to as RY1-RY4 were synthesized, and their chemical backbones were confirmed via the employed spectrophotometers. The pharmacokinetic profiles of the synthesized halocoumarins were inspected in silico using a free online software named the pre-ADMET program. The potential of the synthesized halocoumarins as antitumor applicants was evaluated utilizing 5-fluorouracil as a reference drug and the well-authenticated protocol based on the MTT as a visible indicator against eight standard tumor-cell lines. The outcomes acquired from this assessment indicated that the synthesized halocoumarins, except RY1, have less impact as antitumor agents comparing with the standard drug. Also, the halocoumarins revealed roughly the same fashion of activity versus the test cell lines with the greatest inhibitory influence reported against MCF-7 and HeLa. From the calculated pharmacokinetic data and outcomes exhibited from antitumor assessment, the authors concluded that the synthesized halocoumarins, particularly RY1, offered potential applicants as antitumor agents with broad-ranged activity. Besides, the compounds RY1 and RY2 may provide highly valuable scaffolds for synthesizing agents with a powerful antitumor activity versus the breast and cervical cancer phenotypes.","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84272890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2021-04-23DOI: 10.21608/EJCHEM.2021.57506.3253
D. Mohammed, F. Omar
{"title":"Spectrophotometric Determination of carvedilol Via Oxidative Coupling Reaction","authors":"D. Mohammed, F. Omar","doi":"10.21608/EJCHEM.2021.57506.3253","DOIUrl":"https://doi.org/10.21608/EJCHEM.2021.57506.3253","url":null,"abstract":"","PeriodicalId":22429,"journal":{"name":"The Egyptian Journal of Chemistry","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2021-04-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80602807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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