Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.334497
Asmaa Hassan El-Meshad, Ibrahim Abdallah Elboghdady, A. Fikry, Sherin Abdel-Aziz
Background: Ankylosing spondylitis (AS) is a form of spondyloarthropathy (SPA) that is featured by sacroiliac joints (SIJ), axial skeleton, entheses and peripheral joints inflammation. Non-radiographic axial spondyloarthropathy or nr-axSPA is a common early sign of AS before developing radiographic sacroiliitis. Visfatin is an adipokine produced in fat tissue mainly, as well as in skeletal muscle, brain, and hepatocytes. Visfatin has been demonstrated to contribute to bone homeostasis and it can induce pro-inflammatory responses in different cell types. Objective: This study aimed to investigate serum visfatin level among AS, nr-axSPA patients and controls and to elucidate its possible relationship with disease activity. Patients and methods: This was a case-control study, which comprised 26 AS cases, 26 nr-axSPA cases and 27 healthy volunteers age-and sex-matched with the patient groups. ELISA was used in measuring visfatin concentration in the serum of studied subjects. Results: Serum visfatin level was significantly higher in AS and nr-axSPA cases groups in comparison with control group (p<0.001). There was positive correlation between visfatin with Bath AS Disease Activity Index (BASDI) (P= 0.032) and (P=0.001), and Bath AS Functional Index (BASFI) (p=0.004) and (p=0.001) in AS and nr-axSPA groups respectively. There were significant positive correlations between modified Stoke AS Spinal Score (mSASSS) and visfatin values in AS group (p<0.001). Visfatin concentrations didn't correlate with age, BMI, disease duration, ESR, CRP and ASDAS-CRP. Conclusion: Serum visfatin concentration was elevated in cases with AS and nr-axSPA, and it was accompanied by disease activity, functional impairment and radiographic damage.
{"title":"Serum Visfatin levels in Ankylosing Spondylitis: Correlation with Disease Activity","authors":"Asmaa Hassan El-Meshad, Ibrahim Abdallah Elboghdady, A. Fikry, Sherin Abdel-Aziz","doi":"10.21608/ejhm.2024.334497","DOIUrl":"https://doi.org/10.21608/ejhm.2024.334497","url":null,"abstract":"Background: Ankylosing spondylitis (AS) is a form of spondyloarthropathy (SPA) that is featured by sacroiliac joints (SIJ), axial skeleton, entheses and peripheral joints inflammation. Non-radiographic axial spondyloarthropathy or nr-axSPA is a common early sign of AS before developing radiographic sacroiliitis. Visfatin is an adipokine produced in fat tissue mainly, as well as in skeletal muscle, brain, and hepatocytes. Visfatin has been demonstrated to contribute to bone homeostasis and it can induce pro-inflammatory responses in different cell types. Objective: This study aimed to investigate serum visfatin level among AS, nr-axSPA patients and controls and to elucidate its possible relationship with disease activity. Patients and methods: This was a case-control study, which comprised 26 AS cases, 26 nr-axSPA cases and 27 healthy volunteers age-and sex-matched with the patient groups. ELISA was used in measuring visfatin concentration in the serum of studied subjects. Results: Serum visfatin level was significantly higher in AS and nr-axSPA cases groups in comparison with control group (p<0.001). There was positive correlation between visfatin with Bath AS Disease Activity Index (BASDI) (P= 0.032) and (P=0.001), and Bath AS Functional Index (BASFI) (p=0.004) and (p=0.001) in AS and nr-axSPA groups respectively. There were significant positive correlations between modified Stoke AS Spinal Score (mSASSS) and visfatin values in AS group (p<0.001). Visfatin concentrations didn't correlate with age, BMI, disease duration, ESR, CRP and ASDAS-CRP. Conclusion: Serum visfatin concentration was elevated in cases with AS and nr-axSPA, and it was accompanied by disease activity, functional impairment and radiographic damage.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538501","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.334375
Mona Alromaihi
Background: Guillain–Barré syndrome (GBS) is the most common acute autoimmune disease of peripheral nervous system. GBS has received little attention in Saudi Arabia. GBS causes an acute flaccid paralysis that may lead to respiratory failure. So, it requires early diagnosis and management. GBS is a clinical diagnosis which has no international criteria and needs a high index of suspension for diagnosis. It is characterized by a heterogeneous group of clinical presentations that may delay the diagnosis. Objective: this study aimed to conduct an analytical, cross-sectional study based on the data obtained from the online self-administrated questionnaire about the level of awareness of GBS presentation in Qassim region. Materials and methods: This study follows an analytical, cross-sectional design, focusing on data collected through an online self-administered questionnaire to assess awareness of GBS presentation in Qassim region. The study comprised a randomly selected sample of at least 926 participants. Results: The study revealed among 926 participants, 112 were familiar with GBS. Younger participants showed greater awareness. Notably, 62.5% without medical backgrounds knew about GBS. About 75% had personal contact with GBS patients, possibly influencing their awareness. Misconceptions persisted, with only 19.6% recognizing GBS's typical onset duration. Urgency was recognized by 61.6%, but only 29.5% identified the ER as the right care setting. Conclusion: The results unveiled a mix of awareness and misconceptions about GBS. Strengthening education is crucial for better understanding and management.
{"title":"Empowering Communities: Guillain–Barré Syndrome (GBS) Awareness and Education in Qassim, Saudi Arabia","authors":"Mona Alromaihi","doi":"10.21608/ejhm.2024.334375","DOIUrl":"https://doi.org/10.21608/ejhm.2024.334375","url":null,"abstract":"Background: Guillain–Barré syndrome (GBS) is the most common acute autoimmune disease of peripheral nervous system. GBS has received little attention in Saudi Arabia. GBS causes an acute flaccid paralysis that may lead to respiratory failure. So, it requires early diagnosis and management. GBS is a clinical diagnosis which has no international criteria and needs a high index of suspension for diagnosis. It is characterized by a heterogeneous group of clinical presentations that may delay the diagnosis. Objective: this study aimed to conduct an analytical, cross-sectional study based on the data obtained from the online self-administrated questionnaire about the level of awareness of GBS presentation in Qassim region. Materials and methods: This study follows an analytical, cross-sectional design, focusing on data collected through an online self-administered questionnaire to assess awareness of GBS presentation in Qassim region. The study comprised a randomly selected sample of at least 926 participants. Results: The study revealed among 926 participants, 112 were familiar with GBS. Younger participants showed greater awareness. Notably, 62.5% without medical backgrounds knew about GBS. About 75% had personal contact with GBS patients, possibly influencing their awareness. Misconceptions persisted, with only 19.6% recognizing GBS's typical onset duration. Urgency was recognized by 61.6%, but only 29.5% identified the ER as the right care setting. Conclusion: The results unveiled a mix of awareness and misconceptions about GBS. Strengthening education is crucial for better understanding and management.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139538510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.334367
A. Saber, Mohamed H. Abdallah, Abdallah Nosair, Eman Salah, Eldin Elsakaan, Mahmoud Abdeltawab, Mahmoud Atia Gbre, Ahmed Elsharkawy, Eman Mahmoud, Sherif Nasr, Ibrahim Elsayed
Background: Moderate-to-severe ischemic mitral regurgitation (IMR) accounts for 10-20% of ischemic heart disease (IHD) cases. Although the widespread recommendations by the guidelines for dealing with it surgically, they don’t clearly address mitral valve (MV) repair to be of choice over MV replacement (MVR) due to the numerous contradictory and un-conclusive results reported about both techniques. Objective: This study aimed to evaluate the impact of MVR in treating moderate-to-severe IMR on one-year outcomes [left ventricular (LV) function, mortality, major cardiac problems, cerebrovascular adverse events, functional status, and quality of life]. Patients and methods: This retrospective study included twenty-three patients presented with IHD complicated with moderate-to-severe IMR and operated upon by coronary artery bypass grafting (CABG) and MVR. All relevant data were evaluated in the preoperative, intraoperative, and over one-year postoperative periods. Results: The mean age was 58.22 ± 3.58 years. They were all in Canadian Cardiovascular Society (CCS) grade III. The mean preoperative left ventricular ejection fraction per cent (LVEF %) was 40.75 ± 1.35. Intraoperative mortality was nil. Early (immediate) postoperative mortality was 4.34%. Late mortality was nil. The overall hospital complications rate was 21.73%. The overall one-year survival rate was 95.65% with statistically significant improvement of LVEF% with a mean of 52.86 ± 1.59 (p<0.001), CCS grade and New York Heart Association (NYHA) class whereas 90.91% were in CCS grade I and NYHA class I while 9.09% in CCS grade II and NYHA class II (p<0.001). Conclusion: Although conjoint MVR with CABG resembles an aggressive approach for treating moderate-to-severe IMR, its performance is safe and beneficial. Even hazardous in the early postoperative period, it showed lower rates of intraoperative, early and late mortality and morbidities particularly the newly developed postoperative atrial fibrillation (AF) and low cardiac output syndrome. At one-year follow-up period, it resulted in preserving and augmenting the LV systolic function improving significantly the impaired preoperative LVEF% and the functional clinical status of the patients.
{"title":"The Impact of Mitral Valve Replacement in Treating Moderate-to-Severe Ischemic Mitral Regurgitation on Preservation of the Left Ventricular Function","authors":"A. Saber, Mohamed H. Abdallah, Abdallah Nosair, Eman Salah, Eldin Elsakaan, Mahmoud Abdeltawab, Mahmoud Atia Gbre, Ahmed Elsharkawy, Eman Mahmoud, Sherif Nasr, Ibrahim Elsayed","doi":"10.21608/ejhm.2024.334367","DOIUrl":"https://doi.org/10.21608/ejhm.2024.334367","url":null,"abstract":"Background: Moderate-to-severe ischemic mitral regurgitation (IMR) accounts for 10-20% of ischemic heart disease (IHD) cases. Although the widespread recommendations by the guidelines for dealing with it surgically, they don’t clearly address mitral valve (MV) repair to be of choice over MV replacement (MVR) due to the numerous contradictory and un-conclusive results reported about both techniques. Objective: This study aimed to evaluate the impact of MVR in treating moderate-to-severe IMR on one-year outcomes [left ventricular (LV) function, mortality, major cardiac problems, cerebrovascular adverse events, functional status, and quality of life]. Patients and methods: This retrospective study included twenty-three patients presented with IHD complicated with moderate-to-severe IMR and operated upon by coronary artery bypass grafting (CABG) and MVR. All relevant data were evaluated in the preoperative, intraoperative, and over one-year postoperative periods. Results: The mean age was 58.22 ± 3.58 years. They were all in Canadian Cardiovascular Society (CCS) grade III. The mean preoperative left ventricular ejection fraction per cent (LVEF %) was 40.75 ± 1.35. Intraoperative mortality was nil. Early (immediate) postoperative mortality was 4.34%. Late mortality was nil. The overall hospital complications rate was 21.73%. The overall one-year survival rate was 95.65% with statistically significant improvement of LVEF% with a mean of 52.86 ± 1.59 (p<0.001), CCS grade and New York Heart Association (NYHA) class whereas 90.91% were in CCS grade I and NYHA class I while 9.09% in CCS grade II and NYHA class II (p<0.001). Conclusion: Although conjoint MVR with CABG resembles an aggressive approach for treating moderate-to-severe IMR, its performance is safe and beneficial. Even hazardous in the early postoperative period, it showed lower rates of intraoperative, early and late mortality and morbidities particularly the newly developed postoperative atrial fibrillation (AF) and low cardiac output syndrome. At one-year follow-up period, it resulted in preserving and augmenting the LV systolic function improving significantly the impaired preoperative LVEF% and the functional clinical status of the patients.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540124","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.336153
Reem M. Rizk, Samir M. Attia, Ahmed M. Abd-Elmodaber, Mohamed Elsaid Ahmed
Background : Trauma has been demonstrated to be responsible for a considerable number of emergency visits worldwide. Abdominal trauma participates significantly in the morbimortality of trauma cases. Of note, there were several studies that evaluated the role of Shock Index (SI) in the context of abdominal traumas. However, fewer researches only that emphasized on the role of FASILA score. Objective : To compare these three scoring systems (FASILA Score versus Shock Index (SI) and Assessment of Blood Consumption (ABC Score)) to detect which is a better predictor for MTP activation in cases with abdominal traumas. Patients and Methods : This was an observational prospective study conducted on a total of 54 patients admitted to the Emergency Department (ED) with abdominal trauma. The FASILA score was evaluated in terms of cases with abdominal injuries, for the initial prediction of massive blood transfusion (MBT) together with being an acronym for FAST+SI+lactate. Results : The median SI, ABC and FASILA score were 1.4, 3 and 6 respectively. Cases with MBT were accompanied by a considerable increase in FASILA score compared to MBT free ones, while SI and ABC demonstrated insignificant differences between both groups (P>0.05). ABC could be used as a predictor for MBT with a higher sensitivity (Sn) and lower specificity (Sp). FASILA could be used as a significant predictor for MBT with higher Sn and Sp. Conclusion : The FASILA score may be used as a promising feasible and simple modality, which predicts the need for BT and MTP activation, in patients with abdominal trauma
{"title":"The FASILA Score versus Shock Index and ABC Score to Predict Need for Massive Blood Transfusion in Patients with Abdominal Trauma","authors":"Reem M. Rizk, Samir M. Attia, Ahmed M. Abd-Elmodaber, Mohamed Elsaid Ahmed","doi":"10.21608/ejhm.2024.336153","DOIUrl":"https://doi.org/10.21608/ejhm.2024.336153","url":null,"abstract":"Background : Trauma has been demonstrated to be responsible for a considerable number of emergency visits worldwide. Abdominal trauma participates significantly in the morbimortality of trauma cases. Of note, there were several studies that evaluated the role of Shock Index (SI) in the context of abdominal traumas. However, fewer researches only that emphasized on the role of FASILA score. Objective : To compare these three scoring systems (FASILA Score versus Shock Index (SI) and Assessment of Blood Consumption (ABC Score)) to detect which is a better predictor for MTP activation in cases with abdominal traumas. Patients and Methods : This was an observational prospective study conducted on a total of 54 patients admitted to the Emergency Department (ED) with abdominal trauma. The FASILA score was evaluated in terms of cases with abdominal injuries, for the initial prediction of massive blood transfusion (MBT) together with being an acronym for FAST+SI+lactate. Results : The median SI, ABC and FASILA score were 1.4, 3 and 6 respectively. Cases with MBT were accompanied by a considerable increase in FASILA score compared to MBT free ones, while SI and ABC demonstrated insignificant differences between both groups (P>0.05). ABC could be used as a predictor for MBT with a higher sensitivity (Sn) and lower specificity (Sp). FASILA could be used as a significant predictor for MBT with higher Sn and Sp. Conclusion : The FASILA score may be used as a promising feasible and simple modality, which predicts the need for BT and MTP activation, in patients with abdominal trauma","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139540201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.337736
Mai Abdullah Elmahdy, Mai Magdy Anwer
Background: Diabetes mellitus (DM) is a major public health issue in Egypt and is regarded as a pandemic of modern times. Most medical professionals that help diabetic people manage their difficulties are nurses. Nutrition is a key element of diabetes control. Objective: This study aimed to evaluate nurses' knowledge, attitudes, and practices (KAP) on the dietary treatment of diabetes. Subjects and methods: A cross-sectional based survey was carried out on nurses working in medical and surgical departments, Benha University Hospital through the period from 1 June 2023 to 30 July 2023. To evaluate nurses' KAP, a verified self-administered questionnaire was utilized. The data were analyzed using descriptive statistics and multiple linear regression to detect predictors for nurses' knowledge, attitude and practice scores. Results: Age and awareness of national diabetes guidelines were revealed to be statistically significant determinants of participants' knowledge of dietary treatment for diabetes. Higher knowledge scores was significantly reported by nurses who were > 41 years (B = 7.68, P=0.03) and those who were aware of National Diabetes Guidelines (B = -5.39, P=0.02). Only 44% of nurses expressed satisfaction with the nutrition education received during their training in nursing universities and institutes. 86% never attended a refresher course on managing diabetes. Most nurses (68%) felt they had a responsibility and were qualified to educate patients about diabetes nutrition. It was shown that 60.6% of Benha University Hospitals’ nurses had knowledge levels that were below average. Participants generally showed a moderate degree of understanding of the dietary treatment of diabetes. Conclusion: Although nurses’ attitudes towards nutritional management of diabetic patients were good. In this study, the nurses declared a modest level of knowledge and practices in relation to the dietary care of diabetes mellitus.
{"title":"Assessment of Nurses' Knowledge, Attitude and Practice Regarding Nutritional Care Management of Diabetic Patients in Benha University Hospital","authors":"Mai Abdullah Elmahdy, Mai Magdy Anwer","doi":"10.21608/ejhm.2024.337736","DOIUrl":"https://doi.org/10.21608/ejhm.2024.337736","url":null,"abstract":"Background: Diabetes mellitus (DM) is a major public health issue in Egypt and is regarded as a pandemic of modern times. Most medical professionals that help diabetic people manage their difficulties are nurses. Nutrition is a key element of diabetes control. Objective: This study aimed to evaluate nurses' knowledge, attitudes, and practices (KAP) on the dietary treatment of diabetes. Subjects and methods: A cross-sectional based survey was carried out on nurses working in medical and surgical departments, Benha University Hospital through the period from 1 June 2023 to 30 July 2023. To evaluate nurses' KAP, a verified self-administered questionnaire was utilized. The data were analyzed using descriptive statistics and multiple linear regression to detect predictors for nurses' knowledge, attitude and practice scores. Results: Age and awareness of national diabetes guidelines were revealed to be statistically significant determinants of participants' knowledge of dietary treatment for diabetes. Higher knowledge scores was significantly reported by nurses who were > 41 years (B = 7.68, P=0.03) and those who were aware of National Diabetes Guidelines (B = -5.39, P=0.02). Only 44% of nurses expressed satisfaction with the nutrition education received during their training in nursing universities and institutes. 86% never attended a refresher course on managing diabetes. Most nurses (68%) felt they had a responsibility and were qualified to educate patients about diabetes nutrition. It was shown that 60.6% of Benha University Hospitals’ nurses had knowledge levels that were below average. Participants generally showed a moderate degree of understanding of the dietary treatment of diabetes. Conclusion: Although nurses’ attitudes towards nutritional management of diabetic patients were good. In this study, the nurses declared a modest level of knowledge and practices in relation to the dietary care of diabetes mellitus.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140527041","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.347084
Eman S. Elbash, Ahmed Fawzi, Ahmad S. Hasan, Ahmed Abdelkhabir Ahmed, Departments of, Andrology Dermatology
Background : Warts are common benign epidermal lesions caused by human papillomavirus (HPV) infection. IgE is the classic anaphylactic antibody that mediates the most immediate allergic and anaphylactic reactions and works to produce immunity against parasites and intracellular pathogens like viruses. Tumor necrosis factor α (TNFα) is considered as a pro-inflammatory cytokine, which is responsible for many functions like causing of cytolysis of specific tumor cell lines. Objective : To study the level of the immunoglobulin E (IgE) and TNFα in the sera of patients suffering from warts resistant to cryotherapy. Patients and Methods : This study was a case control study that included 90 subjects divided into 2 groups, case group that included 45 patients with warts and control group that included 45 age and sex matched healthy controls. This study included patients suffering from warts after 2 weeks of the last session of cryotherapy after receiving 2 sessions at least. Laboratory tests included measurement of serum IgE and serum TNFα. Results : About half of the patients had plantar warts, 42.2% had common warts, and 6.7% had genital warts. Median TNFα and IgE serum levels in this study were significantly higher among cases in comparison with controls. No significant relation was reported between TNFα and IgE serum levels and number of warts, type of warts, site of warts or number of sessions. Conclusion : Serum levels of TNFα and IgE were significantly elevated in patients suffering from warts resistant to cryotherapy in comparison with healthy individuals.
{"title":"Evaluation of Serum Level of IgE (Total) and TNFα in Warts Resistant to Cryotherapy","authors":"Eman S. Elbash, Ahmed Fawzi, Ahmad S. Hasan, Ahmed Abdelkhabir Ahmed, Departments of, Andrology Dermatology","doi":"10.21608/ejhm.2024.347084","DOIUrl":"https://doi.org/10.21608/ejhm.2024.347084","url":null,"abstract":"Background : Warts are common benign epidermal lesions caused by human papillomavirus (HPV) infection. IgE is the classic anaphylactic antibody that mediates the most immediate allergic and anaphylactic reactions and works to produce immunity against parasites and intracellular pathogens like viruses. Tumor necrosis factor α (TNFα) is considered as a pro-inflammatory cytokine, which is responsible for many functions like causing of cytolysis of specific tumor cell lines. Objective : To study the level of the immunoglobulin E (IgE) and TNFα in the sera of patients suffering from warts resistant to cryotherapy. Patients and Methods : This study was a case control study that included 90 subjects divided into 2 groups, case group that included 45 patients with warts and control group that included 45 age and sex matched healthy controls. This study included patients suffering from warts after 2 weeks of the last session of cryotherapy after receiving 2 sessions at least. Laboratory tests included measurement of serum IgE and serum TNFα. Results : About half of the patients had plantar warts, 42.2% had common warts, and 6.7% had genital warts. Median TNFα and IgE serum levels in this study were significantly higher among cases in comparison with controls. No significant relation was reported between TNFα and IgE serum levels and number of warts, type of warts, site of warts or number of sessions. Conclusion : Serum levels of TNFα and IgE were significantly elevated in patients suffering from warts resistant to cryotherapy in comparison with healthy individuals.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140520117","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.339695
{"title":"Hepatocellular Carcinoma Recurrence Post Direct-Acting Antiviral and Its Relation to Time of Treating Chronic HCV Infection","authors":"","doi":"10.21608/ejhm.2024.339695","DOIUrl":"https://doi.org/10.21608/ejhm.2024.339695","url":null,"abstract":"","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140519942","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.340843
Asmaa Shaban, Hasan, Mohamed Khaled Selim, Mayada A. Ghannam, Amal Wagdy, Departments of, Andrology Dermatology
Background: Psoriasis vulgaris (PV) is a chronic proliferative inflammatory dermal disease. Orosomucoid (ORM) is an acute phase protein (APP) primarily formed in the liver. Novel research revealed urinary orosomucoid (uORM) as a more sensitive, noninvasive biomarker of inflammatory activation compared to serum ORM (se-ORM). Objective: To investigate the role of uORM as a surrogate marker for psoriasis and to correlate its urinary values with the PV severity. Patients and Methods: This was a case-control study, comprised 50 cases with confirmed diagnosis of psoriasis and control group included 50 healthy controls. The included cases were classified based on PASI score into; mild PV (≤10), moderate PV (>10 -<20) and severe PV (≥20). Morning urine samples were acquired from all cases and controls to measure urinary ORM. Results: The AUC for uORM A in differentiating cases from control was fair with the best detected cutoff point was 53.18 yielding sensitivity of 74% and specificity 58%, and for uORM A/creatinine in differentiating cases from control was fair with the best detected cutoff point was 0.293 yielding sensitivity of 70% and specificity 52%. There was a statistically significant higher median uORM A, uORM A/ creatinine among severe cases than mild and, moderate cases. Conclusions: A highly sensitive, inexpensive, and easily available noninvasive biomarker, uORM demonstrates itself ability to become a new inflammatory marker in PV offering further data on disease severity and progression.
{"title":"Urinary Orosomucoid as a Potential Marker of Inflammation in Psoriasis Vulgaris","authors":"Asmaa Shaban, Hasan, Mohamed Khaled Selim, Mayada A. Ghannam, Amal Wagdy, Departments of, Andrology Dermatology","doi":"10.21608/ejhm.2024.340843","DOIUrl":"https://doi.org/10.21608/ejhm.2024.340843","url":null,"abstract":"Background: Psoriasis vulgaris (PV) is a chronic proliferative inflammatory dermal disease. Orosomucoid (ORM) is an acute phase protein (APP) primarily formed in the liver. Novel research revealed urinary orosomucoid (uORM) as a more sensitive, noninvasive biomarker of inflammatory activation compared to serum ORM (se-ORM). Objective: To investigate the role of uORM as a surrogate marker for psoriasis and to correlate its urinary values with the PV severity. Patients and Methods: This was a case-control study, comprised 50 cases with confirmed diagnosis of psoriasis and control group included 50 healthy controls. The included cases were classified based on PASI score into; mild PV (≤10), moderate PV (>10 -<20) and severe PV (≥20). Morning urine samples were acquired from all cases and controls to measure urinary ORM. Results: The AUC for uORM A in differentiating cases from control was fair with the best detected cutoff point was 53.18 yielding sensitivity of 74% and specificity 58%, and for uORM A/creatinine in differentiating cases from control was fair with the best detected cutoff point was 0.293 yielding sensitivity of 70% and specificity 52%. There was a statistically significant higher median uORM A, uORM A/ creatinine among severe cases than mild and, moderate cases. Conclusions: A highly sensitive, inexpensive, and easily available noninvasive biomarker, uORM demonstrates itself ability to become a new inflammatory marker in PV offering further data on disease severity and progression.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140522232","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.340841
Manar Ahmed Wahba, Omaima MA Kattabei, M. Sedhom
Background : Low back pain (LBP) is prevalent among people's musculoskeletal systems, particularly among farmers. Furthermore, it frequently results in missed pay and significant medical bills. Aim : The purpose of this research was to find out how prevalent mechanical LBP among Egyptian farmers during transplanting process in Giza and to determine the association between number of working years and mechanical LBP in farmers of Giza, Egypt. Subjects and Methods : A cross-sectional survey of 270 farmers was undertaken. Their ages ranged from 18 to 60. Face-to-face interviews were used to gather data. The intensity of pain, degree of functional impairment, and lumbar range of motion were assessed via the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and lumbar flexibility test. In addition to measuring scales, anthropometry, personal and vocational history were gathered. Results : The prevalence of mechanical LBP in farmers was 65.6% among the 270 farmers studied and there was a substantial association between mechanical LBP and working years (P₌0.001) as with increasing the farming years there was an increase in incidence of mechanical LBP. Conclusions : Farmers exhibit a substantially elevated occurrence of mechanical low back pain and experience functional limitations as a consequence of this condition.
{"title":"Prevalence of Mechanical Low Back Pain among Field Farmers in Giza-Egypt","authors":"Manar Ahmed Wahba, Omaima MA Kattabei, M. Sedhom","doi":"10.21608/ejhm.2024.340841","DOIUrl":"https://doi.org/10.21608/ejhm.2024.340841","url":null,"abstract":"Background : Low back pain (LBP) is prevalent among people's musculoskeletal systems, particularly among farmers. Furthermore, it frequently results in missed pay and significant medical bills. Aim : The purpose of this research was to find out how prevalent mechanical LBP among Egyptian farmers during transplanting process in Giza and to determine the association between number of working years and mechanical LBP in farmers of Giza, Egypt. Subjects and Methods : A cross-sectional survey of 270 farmers was undertaken. Their ages ranged from 18 to 60. Face-to-face interviews were used to gather data. The intensity of pain, degree of functional impairment, and lumbar range of motion were assessed via the Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), and lumbar flexibility test. In addition to measuring scales, anthropometry, personal and vocational history were gathered. Results : The prevalence of mechanical LBP in farmers was 65.6% among the 270 farmers studied and there was a substantial association between mechanical LBP and working years (P₌0.001) as with increasing the farming years there was an increase in incidence of mechanical LBP. Conclusions : Farmers exhibit a substantially elevated occurrence of mechanical low back pain and experience functional limitations as a consequence of this condition.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140524793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-01-01DOI: 10.21608/ejhm.2024.339692
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