Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.349391
Youssef Abdel Zaher, Marwa Mohamed Naguib², Emad M. Abdelrahman, Dina AbdelhadyMohammed, Hamasat Abdelhafiz Elnoury, Ali A. Morsy
Background: Nematodes represent a continuous worldwide challenge with formidable burden on health and economics. Objective: The study aimed to assess the prevalence of nematodes parasitosis (NP) among pregnant women and its relation to the pregnancy-associated complications (PACs). Patients and Methods : In the current study 792 pregnant women were clinically evaluated and gave blood samples and three stool specimens per woman for parasitological evaluation. All women attended the follow-up visits and gave labor at the hospital. The frequency of PACs was determined and its relation to NP was examined statistically. Results: Multiple nematode species were detected in 185 specimens with A. lumbricoides, E. vermicularis, and T. trichiura represented 76.2% of the detected parasites in varied combinations, while T. spiralis was the least and was detected using human anti-trichinella spiralis IgG ELISA kit. The incidence of PACs was significantly higher among infected women with anemia was the commonest. The frequency of low hemoglobin concentration (HBC) was significantly higher, the average HBC was significantly lower, and the frequency of moderate and severe anemia was significantly higher among the infected women. The number of women who had instrumentally aided vaginal delivery or operative delivery was significantly higher among infected women. Conclusion : Nematode parasitosis is an ecological problem and is frequent among pregnant women especially those dependent on outdoor food staffs. Multiple-families NP is significant predictor for upcoming PACs. NP in obese pregnant women especially older ones has more deleterious impact on pregnancy.
{"title":"Peri-conception Nematode Parasitosis Is an Ecological Problem but Solely Is Not a Risk for Complicated Pregnancy","authors":"Youssef Abdel Zaher, Marwa Mohamed Naguib², Emad M. Abdelrahman, Dina AbdelhadyMohammed, Hamasat Abdelhafiz Elnoury, Ali A. Morsy","doi":"10.21608/ejhm.2024.349391","DOIUrl":"https://doi.org/10.21608/ejhm.2024.349391","url":null,"abstract":"Background: Nematodes represent a continuous worldwide challenge with formidable burden on health and economics. Objective: The study aimed to assess the prevalence of nematodes parasitosis (NP) among pregnant women and its relation to the pregnancy-associated complications (PACs). Patients and Methods : In the current study 792 pregnant women were clinically evaluated and gave blood samples and three stool specimens per woman for parasitological evaluation. All women attended the follow-up visits and gave labor at the hospital. The frequency of PACs was determined and its relation to NP was examined statistically. Results: Multiple nematode species were detected in 185 specimens with A. lumbricoides, E. vermicularis, and T. trichiura represented 76.2% of the detected parasites in varied combinations, while T. spiralis was the least and was detected using human anti-trichinella spiralis IgG ELISA kit. The incidence of PACs was significantly higher among infected women with anemia was the commonest. The frequency of low hemoglobin concentration (HBC) was significantly higher, the average HBC was significantly lower, and the frequency of moderate and severe anemia was significantly higher among the infected women. The number of women who had instrumentally aided vaginal delivery or operative delivery was significantly higher among infected women. Conclusion : Nematode parasitosis is an ecological problem and is frequent among pregnant women especially those dependent on outdoor food staffs. Multiple-families NP is significant predictor for upcoming PACs. NP in obese pregnant women especially older ones has more deleterious impact on pregnancy.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"17 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764409","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.348923
H. Abdelwahab
Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) one of the most common and serious complications causing morbidity and mortality Aim of study: This study aimed to assess patient and technical factors that may be related to PEP Patient and methods: We observed 120 patients who developed signs of pancreatitis after ERCP, clinical data and procedural details were recorded in these patients to be evaluated Results: A total of 120 studied patients, their mean age was 37.38 ± 12.51 years, 63.3% were females, the most noted indication of ERCP was choledocholithiasis, 24.2% of patient have history of pancreatitis, long time of procedure was noted in these cases, precut sphincterotomy in 55% and pancreatic duct cannulation was noted in 53.3% of cases, moreover increased difficulty of cannulation occur more in our patients. Conclusion: Patients’ related factors as young age, female sex and indication of ERCP, and technical-related factors as precut sphincterotomy and pancreatic cannulation may contribute to PEP.
{"title":"Patient And Procedure Related Risk Factors of Post-ERCP Pancreatitis In Assiut University Hospital","authors":"H. Abdelwahab","doi":"10.21608/ejhm.2024.348923","DOIUrl":"https://doi.org/10.21608/ejhm.2024.348923","url":null,"abstract":"Background: Post-endoscopic retrograde cholangiopancreatography (ERCP) pancreatitis (PEP) one of the most common and serious complications causing morbidity and mortality Aim of study: This study aimed to assess patient and technical factors that may be related to PEP Patient and methods: We observed 120 patients who developed signs of pancreatitis after ERCP, clinical data and procedural details were recorded in these patients to be evaluated Results: A total of 120 studied patients, their mean age was 37.38 ± 12.51 years, 63.3% were females, the most noted indication of ERCP was choledocholithiasis, 24.2% of patient have history of pancreatitis, long time of procedure was noted in these cases, precut sphincterotomy in 55% and pancreatic duct cannulation was noted in 53.3% of cases, moreover increased difficulty of cannulation occur more in our patients. Conclusion: Patients’ related factors as young age, female sex and indication of ERCP, and technical-related factors as precut sphincterotomy and pancreatic cannulation may contribute to PEP.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"148 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140767278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.348922
Ahmed Adel, Abdel Fattah Badr, Amal Shawky Bakir, Hany Ali, Salah Abdel Rahman, Shaarawy Galal, Salah Shaarawy, Galal
Background: For the purpose of making decisions and providing treatment for individuals infected with HCV, liver fibrosis must be accurately staged. Prior to starting medication, the degree of the fibrosis should be evaluated. cirrhosis patients must be identified in order to establish treatment plans and to monitor HCC patients after treatment. Objective: This study aimed to find a readily accessible haematological CBC markers, a regular, low-cost method of predicting severe fibrosis and cirrhosis. Patients and methods: The study included 50 patients with chronic hepatitis C virus. They were divided into two groups: Group I included 25 Non-cirrhotic patients having chronic HCV infection and group II that included 25 cirrhotic CHILD A patients having chronic HCV infection. Results: Before treatment, sensitivity and specificity for RDW/Platelet ratio, APRI and FIB_4 for fibrosis cases (F1, F2 & F3) were evaluated by constructing ROC curve, which showed an excellent (in FIB_4) and good (in RDW/Platelet ratio & APRI) degree of accuracy. The areas under the ROC curve for RDW/Platelet ratio, APRI and FIB_4 were (0.857, 0.821 and 0.911) respectively. For APRI at cut off point 0.35, the sensitivity was 75%. For FIB_4 at cut off point 1.39, the sensitivity was 100%. After treatment, sensitivity and specificity for RDW/Platelet ratio, APRI, FIB_4 for fibrosis cases (F1, F2) and sensitivity & specificity for RDW/Platelet ratio, APRI, FIB_4 for cirrhotic cases (F3, F4) were evaluated. For APRI at cut off point 0.65, the sensitivity was 100% For FIB_4 at cut off point 1.895, the sensitivity was 100%. Conclusion: According to our findings, RDW/PLT might accurately determine the degree of liver fibrosis and cirrhosis prior to HCV therapy. While following HCV therapy, we may rely on RDW/PLT to predict the degree of advanced liver fibrosis and cirrhosis (F3 & F4) with great accuracy.
{"title":"Evaluation of Red Cell Distribution Width (RDW) to Platelet Ratio as A Novel Non-Invasive Index for Predicting Hepatic Fibrosis in Patients with Chronic Hepatitis C before and after Antiviral Treatment","authors":"Ahmed Adel, Abdel Fattah Badr, Amal Shawky Bakir, Hany Ali, Salah Abdel Rahman, Shaarawy Galal, Salah Shaarawy, Galal","doi":"10.21608/ejhm.2024.348922","DOIUrl":"https://doi.org/10.21608/ejhm.2024.348922","url":null,"abstract":"Background: For the purpose of making decisions and providing treatment for individuals infected with HCV, liver fibrosis must be accurately staged. Prior to starting medication, the degree of the fibrosis should be evaluated. cirrhosis patients must be identified in order to establish treatment plans and to monitor HCC patients after treatment. Objective: This study aimed to find a readily accessible haematological CBC markers, a regular, low-cost method of predicting severe fibrosis and cirrhosis. Patients and methods: The study included 50 patients with chronic hepatitis C virus. They were divided into two groups: Group I included 25 Non-cirrhotic patients having chronic HCV infection and group II that included 25 cirrhotic CHILD A patients having chronic HCV infection. Results: Before treatment, sensitivity and specificity for RDW/Platelet ratio, APRI and FIB_4 for fibrosis cases (F1, F2 & F3) were evaluated by constructing ROC curve, which showed an excellent (in FIB_4) and good (in RDW/Platelet ratio & APRI) degree of accuracy. The areas under the ROC curve for RDW/Platelet ratio, APRI and FIB_4 were (0.857, 0.821 and 0.911) respectively. For APRI at cut off point 0.35, the sensitivity was 75%. For FIB_4 at cut off point 1.39, the sensitivity was 100%. After treatment, sensitivity and specificity for RDW/Platelet ratio, APRI, FIB_4 for fibrosis cases (F1, F2) and sensitivity & specificity for RDW/Platelet ratio, APRI, FIB_4 for cirrhotic cases (F3, F4) were evaluated. For APRI at cut off point 0.65, the sensitivity was 100% For FIB_4 at cut off point 1.895, the sensitivity was 100%. Conclusion: According to our findings, RDW/PLT might accurately determine the degree of liver fibrosis and cirrhosis prior to HCV therapy. While following HCV therapy, we may rely on RDW/PLT to predict the degree of advanced liver fibrosis and cirrhosis (F3 & F4) with great accuracy.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"129 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140794026","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.348391
Hanan I. El-kerdasy, Amal Ghoneimy Metwally
Background and Objective: Chrysin has been used for suppression of inducible nitric oxide synthase. Zinc inhibits the production of oxygen-free radicals. This study aimed to assess the possible ameliorative role of chrysin and zinc on lead acetate nephrotoxicity. Material and Methods: The study involved forty-five adult male albino rats that were categorized into, control group, lead acetate group, chrysin-treated group, zinc-treated group and chrysin plus zinc-treated group. At the end of the study blood samples were collected by cardiac puncture for laboratory analysis of blood urea and creatinine. The kidneys were collected and subjected to biochemical analysis, histological and immune-histochemical study. Result : Lead acetate elevated the blood urea and creatinine level, the tissue malondialdehyde MDA level and reduced the level of antioxidant enzymes. It interrupted the normal histological structures of renal sections, elevated the main area percent of collagen fiber deposition, and P53 and TNF α positive immuno-reactivity. Both chrysin and zinc significantly declined the toxic effect of lead acetate in chrysin-treated group and zinc-treated group. Chrysin and zinc co-treatment has significantly decreased the blood urea and creatinine levels, malondialdehyde level, collagen fiber deposition, and P53 and TNF α positive immuno-reactivity and significantly increased the antioxidant enzyme levels compared to chrysin-treated group and zinc-treated group. Conclusion : Lead acetate induced serious renal injury. Chrysin and zinc alone improved the toxic changes of lead acetate. However, coadministration of chrysin and zinc have a powerful ameliorative effect than chrysin and zinc alone.
{"title":"The Possible Ameliorative Role of Chrysin and Zinc on Lead Acetate Induced Nephrotoxicity in Adult Albino Rats (Biochemical, Histological and Immunohistochemical study)","authors":"Hanan I. El-kerdasy, Amal Ghoneimy Metwally","doi":"10.21608/ejhm.2024.348391","DOIUrl":"https://doi.org/10.21608/ejhm.2024.348391","url":null,"abstract":"Background and Objective: Chrysin has been used for suppression of inducible nitric oxide synthase. Zinc inhibits the production of oxygen-free radicals. This study aimed to assess the possible ameliorative role of chrysin and zinc on lead acetate nephrotoxicity. Material and Methods: The study involved forty-five adult male albino rats that were categorized into, control group, lead acetate group, chrysin-treated group, zinc-treated group and chrysin plus zinc-treated group. At the end of the study blood samples were collected by cardiac puncture for laboratory analysis of blood urea and creatinine. The kidneys were collected and subjected to biochemical analysis, histological and immune-histochemical study. Result : Lead acetate elevated the blood urea and creatinine level, the tissue malondialdehyde MDA level and reduced the level of antioxidant enzymes. It interrupted the normal histological structures of renal sections, elevated the main area percent of collagen fiber deposition, and P53 and TNF α positive immuno-reactivity. Both chrysin and zinc significantly declined the toxic effect of lead acetate in chrysin-treated group and zinc-treated group. Chrysin and zinc co-treatment has significantly decreased the blood urea and creatinine levels, malondialdehyde level, collagen fiber deposition, and P53 and TNF α positive immuno-reactivity and significantly increased the antioxidant enzyme levels compared to chrysin-treated group and zinc-treated group. Conclusion : Lead acetate induced serious renal injury. Chrysin and zinc alone improved the toxic changes of lead acetate. However, coadministration of chrysin and zinc have a powerful ameliorative effect than chrysin and zinc alone.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"209 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140765096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.349085
Mohamed Salem, Mosalam Ali, Ahmad Osama Hosny, Mohamed Ebrahem Negm, Mohamed Abdelfattah Elsamahy, Iman Ahmed Yassine
Background: Stroke is the primary cause of long-term disability and mortality among adults and is classified as a chronic illness. After suffering a stroke, spasticity manifests in around thirty percent of cases. Aim: To evaluate the effect of spasticity in chronic hemiplegic upper extremities on electrophysiological and morphological characteristics of the median and ulnar nerves. Subjects and methods: This was cross-sectional research that was performed on 50 patients with chronic stroke at the Clinical Neurophysiology Unit, Neurology Department of Suez Canal University Hospitals, Suez Canal University and Ultrasonography Unit, Diagnostic Radiology Department, Ismailia, Egypt, from May 2021 to January 2023. All the patients were subjected to clinical evaluations: (Spasticity evaluation: including Brunnstrom Recovery Stages (BRS) and ultrasonographic measurements. Results: There was a statistically significant positive moderate association among ultrasonographic measures of median nerve (distal) and median nerve (proximal). On the paretic side, motor conduction velocities of the median nerve were significantly delayed (mean±SD) (48.3± 9.5) when compared with the non-paretic side (mean±SD) (54.4± 8.3) and p-value (0.020) demonstrated that there were statistically significant variances. The F-wave latencies of the median nerve were significantly higher on the paretic sides (mean ± SD) (32.2± 5.1) when compared with the non-paretic (mean ± SD) (27.5± 3.9) side, and the p-value (0.011) showed that there were statistically significant differences. Conclusion: We concluded that stroke peripheral nerve cases seem to be influenced electrophysiologically on the paretic side. But according to US measurements, they weren’t affected.
{"title":"Ultrasonographic and Electrophysiologic Assessment of Ulnar and Median Nerves in Spastic Upper Limbs in Chronic Stroke Patients","authors":"Mohamed Salem, Mosalam Ali, Ahmad Osama Hosny, Mohamed Ebrahem Negm, Mohamed Abdelfattah Elsamahy, Iman Ahmed Yassine","doi":"10.21608/ejhm.2024.349085","DOIUrl":"https://doi.org/10.21608/ejhm.2024.349085","url":null,"abstract":"Background: Stroke is the primary cause of long-term disability and mortality among adults and is classified as a chronic illness. After suffering a stroke, spasticity manifests in around thirty percent of cases. Aim: To evaluate the effect of spasticity in chronic hemiplegic upper extremities on electrophysiological and morphological characteristics of the median and ulnar nerves. Subjects and methods: This was cross-sectional research that was performed on 50 patients with chronic stroke at the Clinical Neurophysiology Unit, Neurology Department of Suez Canal University Hospitals, Suez Canal University and Ultrasonography Unit, Diagnostic Radiology Department, Ismailia, Egypt, from May 2021 to January 2023. All the patients were subjected to clinical evaluations: (Spasticity evaluation: including Brunnstrom Recovery Stages (BRS) and ultrasonographic measurements. Results: There was a statistically significant positive moderate association among ultrasonographic measures of median nerve (distal) and median nerve (proximal). On the paretic side, motor conduction velocities of the median nerve were significantly delayed (mean±SD) (48.3± 9.5) when compared with the non-paretic side (mean±SD) (54.4± 8.3) and p-value (0.020) demonstrated that there were statistically significant variances. The F-wave latencies of the median nerve were significantly higher on the paretic sides (mean ± SD) (32.2± 5.1) when compared with the non-paretic (mean ± SD) (27.5± 3.9) side, and the p-value (0.011) showed that there were statistically significant differences. Conclusion: We concluded that stroke peripheral nerve cases seem to be influenced electrophysiologically on the paretic side. But according to US measurements, they weren’t affected.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"446 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140779915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Early detection of pulmonary hypertension (PH) in infants with congenital heart disease (CHD) is crucial for timely intervention and management. Serum pentraxin 3 (PTX3) has emerged as a potential biomarker for inflammatory diseases, but its association with PH in the context of CHD has not been thoroughly investigated. Objective: To estimate serum PTX3 levels in CHD infants for early detection of PH and to correlate its level with the severity of PH. Methods: This case-control study involved 80 infants, divided into 50 with CHD (further subdivided into (Group IA) 30 with PH and (Group IB) 20 without PH) and 30 healthy controls. Diagnosis of CHD and PH was confirmed via echocardiography, with PH severity graded according to established criteria. Serum PTX3 levels were measured using ELISA. Results: Infants with CHD and PH (Group IA) exhibited significantly higher serum PTX3 levels (mean ± SD, 8.22 ± 4.38 ng/ml) compared to those with CHD without PH (Group IB) and healthy controls (3.91 ± 1.78 ng/ml, P<0.001). PTX3 levels showed a significant positive correlation with PH severity (r=0.557, P<0.001) and could predict PH incidence with an AUC of 0.832 (95% CI= 0.732 to 0.907), at a cutoff value >4.29 ng/ml with 86.67% sensitivity and 54.00% specificity. Conclusion: Serum PTX3 levels are significantly elevated in infants with CHD and PH, correlating with PH severity. These findings suggest PTX3 as a promising biomarker for the early detection and severity assessment of PH in infants with CHD.
{"title":"Estimation of Serum Levels of Pentraxin 3 in Infants with Congenital Heart Disease for Early Detection of Pulmonary Hypertension","authors":"Somaia Abdel Samie, Elwan, Hesham Abdel Aziz, Elghaiaty, Abdel Aziz, Abdel Atty Mahmoud, Yasser Mahmoud Ismail","doi":"10.21608/ejhm.2024.349390","DOIUrl":"https://doi.org/10.21608/ejhm.2024.349390","url":null,"abstract":"Background: Early detection of pulmonary hypertension (PH) in infants with congenital heart disease (CHD) is crucial for timely intervention and management. Serum pentraxin 3 (PTX3) has emerged as a potential biomarker for inflammatory diseases, but its association with PH in the context of CHD has not been thoroughly investigated. Objective: To estimate serum PTX3 levels in CHD infants for early detection of PH and to correlate its level with the severity of PH. Methods: This case-control study involved 80 infants, divided into 50 with CHD (further subdivided into (Group IA) 30 with PH and (Group IB) 20 without PH) and 30 healthy controls. Diagnosis of CHD and PH was confirmed via echocardiography, with PH severity graded according to established criteria. Serum PTX3 levels were measured using ELISA. Results: Infants with CHD and PH (Group IA) exhibited significantly higher serum PTX3 levels (mean ± SD, 8.22 ± 4.38 ng/ml) compared to those with CHD without PH (Group IB) and healthy controls (3.91 ± 1.78 ng/ml, P<0.001). PTX3 levels showed a significant positive correlation with PH severity (r=0.557, P<0.001) and could predict PH incidence with an AUC of 0.832 (95% CI= 0.732 to 0.907), at a cutoff value >4.29 ng/ml with 86.67% sensitivity and 54.00% specificity. Conclusion: Serum PTX3 levels are significantly elevated in infants with CHD and PH, correlating with PH severity. These findings suggest PTX3 as a promising biomarker for the early detection and severity assessment of PH in infants with CHD.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"64 ","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140762099","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: The breakdown of cross-linked fibrin by plasmin results in D-dimer. The production of fibrin and its subsequent breakdown by the endogenous fibrinolytic system are prerequisites for the plasma concentrations of D-dimer, a coagulation marker. Numerous studies have revealed a link between poor outcomes for individuals hospitalized for myocardial infarction and increased D-dimer levels. Objective: The current work aimed to detect the association between the serum level of D-dimer upon admission and the severity of coronary artery disease (CAD) in patients with ST-elevation myocardial infarction (STEMI). Patients and methods: This prospective observational study included 120 patients with STEMI who were recruited from the Cardiology Department, Menoufia University Hospital and Banha Teaching Hospital. Results: in the current study, the mean syntax II score was 27.82 ± 5.20 and there were 63 cases (52.5%) with High syntax II score (syntax II score ≥ 25). The D-dimer level was statistically significantly higher in the cases with high syntax II score compared to the cases with low syntax II score (p< 0.001). The best cutoff point of D-dimer level to identify cases with high syntax II score was > 1.75 ng/ml with 73.5% sensitivity and 64.5% specificity. The area under the curve was 0.701 and this value showed a statistically significant value (p = 0.001). Conclusion: Serum level of D-dimer could be used as a non-invasive biomarker for detection of the disease severity in cases with acute STEMI.
背景：凝血酶分解交联的纤维蛋白会产生 D-二聚体。纤维蛋白的生成及其随后被内源性纤溶系统分解是凝血标志物 D-二聚体血浆浓度的先决条件。大量研究表明，心肌梗死住院患者的不良预后与 D-二聚体水平升高有关。研究目的本研究旨在检测 ST 段抬高型心肌梗死（STEMI）患者入院时血清中 D-二聚体水平与冠状动脉疾病（CAD）严重程度之间的关系。患者和方法这项前瞻性观察研究纳入了 120 名 STEMI 患者，他们分别来自梅努菲亚大学医院和班哈教学医院的心脏病科。结果：在本次研究中，平均语法 II 得分为 27.82 ± 5.20，有 63 例（52.5%）患者语法 II 得分较高（语法 II 得分≥ 25）。与低综合征 II 评分的病例相比，高综合征 II 评分病例的 D-二聚体水平明显更高（P< 0.001）。D 二聚体水平的最佳临界点为 > 1.75 ng/ml，灵敏度为 73.5%，特异度为 64.5%。曲线下面积为 0.701，该值具有统计学意义（P = 0.001）。结论血清 D-二聚体水平可作为检测急性 STEMI 病例疾病严重程度的无创生物标志物。
{"title":"Relation between D-Dimer Level and Coronary Artery Disease Severity in Patients with ST Segment Elevation Myocardial Infarction","authors":"Ghada Mahmoud Soltan, Mahmoud Zakaria, Abd-Elsattar Aboshady, Tamer Ezzat Ghazy, Mahmoud Zakaria Abd-Elsattar","doi":"10.21608/ejhm.2024.348924","DOIUrl":"https://doi.org/10.21608/ejhm.2024.348924","url":null,"abstract":"Background: The breakdown of cross-linked fibrin by plasmin results in D-dimer. The production of fibrin and its subsequent breakdown by the endogenous fibrinolytic system are prerequisites for the plasma concentrations of D-dimer, a coagulation marker. Numerous studies have revealed a link between poor outcomes for individuals hospitalized for myocardial infarction and increased D-dimer levels. Objective: The current work aimed to detect the association between the serum level of D-dimer upon admission and the severity of coronary artery disease (CAD) in patients with ST-elevation myocardial infarction (STEMI). Patients and methods: This prospective observational study included 120 patients with STEMI who were recruited from the Cardiology Department, Menoufia University Hospital and Banha Teaching Hospital. Results: in the current study, the mean syntax II score was 27.82 ± 5.20 and there were 63 cases (52.5%) with High syntax II score (syntax II score ≥ 25). The D-dimer level was statistically significantly higher in the cases with high syntax II score compared to the cases with low syntax II score (p< 0.001). The best cutoff point of D-dimer level to identify cases with high syntax II score was > 1.75 ng/ml with 73.5% sensitivity and 64.5% specificity. The area under the curve was 0.701 and this value showed a statistically significant value (p = 0.001). Conclusion: Serum level of D-dimer could be used as a non-invasive biomarker for detection of the disease severity in cases with acute STEMI.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"181 33","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140793831","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.348926
Rasha Mahmoud, Ahmed Hassan, Omar Mohamed Aly, Nasr Hassouba Bassant, Sayed Moussa, Khaled Morsy Salama, Bassant S. Moussa
Background: Coronavirus Disease of 2019 (COVID-19) is a global epidemic with thousands of deaths. Objective: This work aimed to compare the prognostic value of rapid scoring systems; the Modified Early Warning Score (MEWS) and Rapid Emergency Medicine Score (REMS) with laboratory markers for mortality in critically ill patients with COVID-19 presenting to the ED. Patients and Methods: This prospective cross-sectional study included a total of 92 patients with confirmed COVID-19, attending the Department of Emergency Medicine, Suez Canal University Hospital, during the period from April 1, 2022, to Oct 1, 2022. Results: D-Dimer was with sensitivity (88%) and specificity (79%) at admission and sensitivity (96%) and specificity (86%) at follow-up; C-reactive protein (CRP) was with sensitivity (96%) and specificity (59%) at follow-up; ferritin was with sensitivity (87%) and specificity (56%) at admission and sensitivity (88%) and specificity (64%) at follow-up; IL-6 was with sensitivity (67%) and specificity (60%) at admission and sensitivity (96%) and specificity (87%) at follow-up; Lactate dehydrogenase(LDH) was with sensitivity (96%) and specificity (60%) at follow-up; and procalcitonin (PCT) was with sensitivity (80%) and specificity (56%) at follow-up. There was a significant difference between both groups regarding the median of MEWS (4 vs. 3, p = 0.004) and REMS (9 vs. 6, p<0.001) that were higher in non-survivors than survivors. Conclusion: REMS was better than the MEWS score in predicting mortality. Also, D-dimer at admission and follow-up, CRP at follow-up, ferritin at admission and follow-up, IL-6 at admission and follow-up, LDH at follow-up, and PCT at follow-up could be used for the prediction of mortality better than rapid scoring systems.
{"title":"Predictive Value of Rapid Scoring Systems and Laboratory Markers in Mortality in Critically ILL Patients with COVID-19: A Prospective Cross-Sectional Study","authors":"Rasha Mahmoud, Ahmed Hassan, Omar Mohamed Aly, Nasr Hassouba Bassant, Sayed Moussa, Khaled Morsy Salama, Bassant S. Moussa","doi":"10.21608/ejhm.2024.348926","DOIUrl":"https://doi.org/10.21608/ejhm.2024.348926","url":null,"abstract":"Background: Coronavirus Disease of 2019 (COVID-19) is a global epidemic with thousands of deaths. Objective: This work aimed to compare the prognostic value of rapid scoring systems; the Modified Early Warning Score (MEWS) and Rapid Emergency Medicine Score (REMS) with laboratory markers for mortality in critically ill patients with COVID-19 presenting to the ED. Patients and Methods: This prospective cross-sectional study included a total of 92 patients with confirmed COVID-19, attending the Department of Emergency Medicine, Suez Canal University Hospital, during the period from April 1, 2022, to Oct 1, 2022. Results: D-Dimer was with sensitivity (88%) and specificity (79%) at admission and sensitivity (96%) and specificity (86%) at follow-up; C-reactive protein (CRP) was with sensitivity (96%) and specificity (59%) at follow-up; ferritin was with sensitivity (87%) and specificity (56%) at admission and sensitivity (88%) and specificity (64%) at follow-up; IL-6 was with sensitivity (67%) and specificity (60%) at admission and sensitivity (96%) and specificity (87%) at follow-up; Lactate dehydrogenase(LDH) was with sensitivity (96%) and specificity (60%) at follow-up; and procalcitonin (PCT) was with sensitivity (80%) and specificity (56%) at follow-up. There was a significant difference between both groups regarding the median of MEWS (4 vs. 3, p = 0.004) and REMS (9 vs. 6, p<0.001) that were higher in non-survivors than survivors. Conclusion: REMS was better than the MEWS score in predicting mortality. Also, D-dimer at admission and follow-up, CRP at follow-up, ferritin at admission and follow-up, IL-6 at admission and follow-up, LDH at follow-up, and PCT at follow-up could be used for the prediction of mortality better than rapid scoring systems.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"386 4","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140780847","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.349082
Abdel-Elsalam Elguindi, Alif Abdel-Hakim, Allam, G. A. Sobhy, Mohammed Fathy, Mahmoud Mostafa, Ahmed Salah, A. Elgawad, Mohammed Fathy Mahmoud
Background: The term "chronic liver disease" (CLD) refers to a long-term, permanent alteration in the structure of the liver that may result in consequences including cirrhosis and early mortality. A potential contributing element to the pathophysiology of chronic liver disorders and the development of complications in cirrhosis is the dysfunction of the intestinal epithelial barrier. One indicator of intestinal permeability is zonulin. Objective: This study aimed to assess serum zonulin levels in CLD with and without cirrhosis in pediatrics. Patients and methods: The study population consisted of 40 children with CLD with cirrhosis, 40 children with CLD without cirrhosis and 20 apparently healthy children serving as a control group. Serum levels of zonulin was determined. Results: The main finding of the current study was that serum zonulin levels were significantly higher in CLD with cirrhosis patients than in CLD without cirrhosis patients or healthy controls (p < 0 001). The median of serum zonulin levels in CLD with cirrhosis patients, CLD without cirrhosis patients, and healthy controls were 264.24, 8.24 and 39.69 ng/mL respectively. Conclusion: Serum zonulin levels were significantly increased in liver cirrhosis patients.
{"title":"Serum Zonulin as a Marker of Intestinal Mucosal Barrier Function in Chronic Liver Diseases in Pediatrics","authors":"Abdel-Elsalam Elguindi, Alif Abdel-Hakim, Allam, G. A. Sobhy, Mohammed Fathy, Mahmoud Mostafa, Ahmed Salah, A. Elgawad, Mohammed Fathy Mahmoud","doi":"10.21608/ejhm.2024.349082","DOIUrl":"https://doi.org/10.21608/ejhm.2024.349082","url":null,"abstract":"Background: The term \"chronic liver disease\" (CLD) refers to a long-term, permanent alteration in the structure of the liver that may result in consequences including cirrhosis and early mortality. A potential contributing element to the pathophysiology of chronic liver disorders and the development of complications in cirrhosis is the dysfunction of the intestinal epithelial barrier. One indicator of intestinal permeability is zonulin. Objective: This study aimed to assess serum zonulin levels in CLD with and without cirrhosis in pediatrics. Patients and methods: The study population consisted of 40 children with CLD with cirrhosis, 40 children with CLD without cirrhosis and 20 apparently healthy children serving as a control group. Serum levels of zonulin was determined. Results: The main finding of the current study was that serum zonulin levels were significantly higher in CLD with cirrhosis patients than in CLD without cirrhosis patients or healthy controls (p < 0 001). The median of serum zonulin levels in CLD with cirrhosis patients, CLD without cirrhosis patients, and healthy controls were 264.24, 8.24 and 39.69 ng/mL respectively. Conclusion: Serum zonulin levels were significantly increased in liver cirrhosis patients.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"315 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140757672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-01DOI: 10.21608/ejhm.2024.348395
Ahmed Mohsen Seleit, K. Kassem, Awad Mohamed El Abd, Mohammed Ahmed Mohieeldin, Inas A. Ahmed, M. G. Sobhy
Background: Allergic rhinitis (AR) is a chronic illness, which most people are afflicted by. Objective: To evaluate the expression of interleukin-33 in patients presenting with allergic rhinitis and nasal polyposis. Patients and Methods: This study was carried out on 50 patients aged from 15 to 40 years old, both sexes, and 25 healthy volunteers matched in age and sex. Patients were allocated into two groups: Case group n= 50 and control group n= 25, then the case group was further subdivided into equal two groups: nasal polyposis group n= 25, and AR group n= 25. All patients were subjected to laboratory investigations, DNA extraction, measurement of DNA concentration, and single nucleotide polymorphism detection. Results: The most predominant genotype in sinusoidal nasal polyps was CT (60%) in both tissue and serum. Conclusions: Il 33 genotype (rs11792633) wasn’t associated with allergic rhinitis and nasal polyps.
{"title":"Study of Interleukin 33 Gene Polymorphism in Egyptian Patients with Allergic Rhinitis","authors":"Ahmed Mohsen Seleit, K. Kassem, Awad Mohamed El Abd, Mohammed Ahmed Mohieeldin, Inas A. Ahmed, M. G. Sobhy","doi":"10.21608/ejhm.2024.348395","DOIUrl":"https://doi.org/10.21608/ejhm.2024.348395","url":null,"abstract":"Background: Allergic rhinitis (AR) is a chronic illness, which most people are afflicted by. Objective: To evaluate the expression of interleukin-33 in patients presenting with allergic rhinitis and nasal polyposis. Patients and Methods: This study was carried out on 50 patients aged from 15 to 40 years old, both sexes, and 25 healthy volunteers matched in age and sex. Patients were allocated into two groups: Case group n= 50 and control group n= 25, then the case group was further subdivided into equal two groups: nasal polyposis group n= 25, and AR group n= 25. All patients were subjected to laboratory investigations, DNA extraction, measurement of DNA concentration, and single nucleotide polymorphism detection. Results: The most predominant genotype in sinusoidal nasal polyps was CT (60%) in both tissue and serum. Conclusions: Il 33 genotype (rs11792633) wasn’t associated with allergic rhinitis and nasal polyps.","PeriodicalId":22467,"journal":{"name":"The Egyptian Journal of Hospital Medicine","volume":"61 22","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140795368","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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