Pub Date : 2013-01-30DOI: 10.5755/J01.CT.62.4.3409
V. Blėkaitytė, I. Jonuškienė, V. Mickevičius
In recent years, the growing interest in medicinal plants and their products led the producers of pharmaceuticals to start utilizing the biomass of cultivated plants instead of collecting the biomass that naturally appears in nature. Most of these plants are grown organically; therefore, they are highly exposed to the pathogens that lower the yield of medicinal plants and modify the chemical composition of the plant extracts. The aim of this work was to evaluate and compare the effect of N -substituted β -alanine derivatives containing 1,4-naphthoquinone and thiazole fragments on the growth of St. John’s wort and its ability to accumulate valuable metabolites. Five β -alanine compounds were used during this research, and three well known compounds (3-indolylacetic acid, 2-methyl-1,4-naphthoquinone, N -phenyl -N -tiocarbamoyl- β -a lanine) were chosen for comparison. The shoots of medicinal plants were evaluated for their growth after treatment with different concentrations (0.25–5 mg/l) of β -alanine derivatives. The highest growth-regulating effect on Hypericum perforatum L. was shown by N -(1,4-naphthoquinon-2-yl)- β -alanine ( 1 ) (1 mg/l) and N -phenyl- N -[(5-(phenyl)methylidene)-4-oxo-2(4H)-thiazolyl]- β -alanine ( 5 ) (1 mg/l); therefore, they were chosen for the further research. The shoots of St. John’s wort were grown on the Murashige & Skoog (MS) medium supplemented with compounds 1 and 5 . The highest amount of pigments (carotenoids, chlorophylls a and b ) after a short period of cultivation was obtained in the leaves of shoots grown on the MS + 1 (1 mg/l) medium; however, treatment with compound 5 increased the content of pigments after a long period (8–9 weeks) of cultivation. According to the results, the highest content of phenolics was found in shoots grown on a medium supplemented with compound 5 . DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3409
{"title":"The influence of N-substituted β-alanines containing naphthoquinone and thiazole moieties on the growth of St. John’s Wort (Hypericum Perforatum L.) and its ability to accumulate metabolites","authors":"V. Blėkaitytė, I. Jonuškienė, V. Mickevičius","doi":"10.5755/J01.CT.62.4.3409","DOIUrl":"https://doi.org/10.5755/J01.CT.62.4.3409","url":null,"abstract":"In recent years, the growing interest in medicinal plants and their products led the producers of pharmaceuticals to start utilizing the biomass of cultivated plants instead of collecting the biomass that naturally appears in nature. Most of these plants are grown organically; therefore, they are highly exposed to the pathogens that lower the yield of medicinal plants and modify the chemical composition of the plant extracts. The aim of this work was to evaluate and compare the effect of N -substituted β -alanine derivatives containing 1,4-naphthoquinone and thiazole fragments on the growth of St. John’s wort and its ability to accumulate valuable metabolites. Five β -alanine compounds were used during this research, and three well known compounds (3-indolylacetic acid, 2-methyl-1,4-naphthoquinone, N -phenyl -N -tiocarbamoyl- β -a lanine) were chosen for comparison. The shoots of medicinal plants were evaluated for their growth after treatment with different concentrations (0.25–5 mg/l) of β -alanine derivatives. The highest growth-regulating effect on Hypericum perforatum L. was shown by N -(1,4-naphthoquinon-2-yl)- β -alanine ( 1 ) (1 mg/l) and N -phenyl- N -[(5-(phenyl)methylidene)-4-oxo-2(4H)-thiazolyl]- β -alanine ( 5 ) (1 mg/l); therefore, they were chosen for the further research. The shoots of St. John’s wort were grown on the Murashige & Skoog (MS) medium supplemented with compounds 1 and 5 . The highest amount of pigments (carotenoids, chlorophylls a and b ) after a short period of cultivation was obtained in the leaves of shoots grown on the MS + 1 (1 mg/l) medium; however, treatment with compound 5 increased the content of pigments after a long period (8–9 weeks) of cultivation. According to the results, the highest content of phenolics was found in shoots grown on a medium supplemented with compound 5 . DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3409","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"1 1","pages":"29-35"},"PeriodicalIF":0.0,"publicationDate":"2013-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"89841905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-30DOI: 10.5755/J01.CT.62.4.3408
E. Meškinytė-Kaušilienė, V. Jukna, J. Klementavičiūtė
The objective of the study was to estimate a correlation between meat quality traits and cholesterol content in M. longissimus dorsi of pigs. The correlation between meat quality traits and cholesterol content varied from weak (0.01) to very strong (0.94). Significant phenotypic correlations were found between pH and meat colour intensity, water holding capacity, and cooking loss ( p < 0.05). The lowest cholesterol amount was found in Lithuanian indigenous and the highest in Lithuanian White pig meat . A l ow correlation between cholesterol content and intramuscular fat content was determined ( r < 0.19). C holesterol is mostly correlated with meat colour yellowness , cooking loss , and the drip loss ( p < 0.01). DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3408
{"title":"Correlations between meat quality traits and cholesterol content in M. longissimus dorsi in pigs of different genotypes","authors":"E. Meškinytė-Kaušilienė, V. Jukna, J. Klementavičiūtė","doi":"10.5755/J01.CT.62.4.3408","DOIUrl":"https://doi.org/10.5755/J01.CT.62.4.3408","url":null,"abstract":"The objective of the study was to estimate a correlation between meat quality traits and cholesterol content in M. longissimus dorsi of pigs. The correlation between meat quality traits and cholesterol content varied from weak (0.01) to very strong (0.94). Significant phenotypic correlations were found between pH and meat colour intensity, water holding capacity, and cooking loss ( p < 0.05). The lowest cholesterol amount was found in Lithuanian indigenous and the highest in Lithuanian White pig meat . A l ow correlation between cholesterol content and intramuscular fat content was determined ( r < 0.19). C holesterol is mostly correlated with meat colour yellowness , cooking loss , and the drip loss ( p < 0.01). DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3408","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"111 1","pages":"45-47"},"PeriodicalIF":0.0,"publicationDate":"2013-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73958168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-30DOI: 10.5755/J01.CT.62.4.3412
E. Berņa, S. Kampuse, M. Sabovics, E. Straumite
Historically, marmalades may have originated as an early effort to preserve fruit for consumption in the off-season. Marmalades are basically products with fruit puree and sugar–acid–pectin gel. The aim of the current research was to determine the chemical and physical properties and to investigate the degree of acceptance of pumpkin – rowanberry marmalade. The experiments were carried out at the Faculty of Food Technology of the Latvia University of Agriculture. The marmalade was made from Cucurbita maxima pumpkin and sweet rowanberry Sorbus aucuparia cultivar ‘Nevezhinskaya’ pur e es. D ifferent drying times in oven at a temperature of 50 ± 2 °C were examined and compared with marmalade drying in air ambiance at room temperature. The moisture, total carotene, ascorbic acid content, hardness, colour, and the degree of acceptance of marmalade samples were determined as quality evaluation. The results of the research have shown a large variability in the physical and chemical parameters among the marmalades after different drying times. The moisture content of marmalade samples decreased by 9.1 to 33.5 %, and hardness increased from 1.85 to 9.54 N. According to sensory evaluation, consumers liked pumpkin–rowanberry marmalade samples after drying in the air ambiance at room temperature. DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3412
{"title":"Evaluation of pumpkin-rowanberry marmalade quality after different drying times","authors":"E. Berņa, S. Kampuse, M. Sabovics, E. Straumite","doi":"10.5755/J01.CT.62.4.3412","DOIUrl":"https://doi.org/10.5755/J01.CT.62.4.3412","url":null,"abstract":"Historically, marmalades may have originated as an early effort to preserve fruit for consumption in the off-season. Marmalades are basically products with fruit puree and sugar–acid–pectin gel. The aim of the current research was to determine the chemical and physical properties and to investigate the degree of acceptance of pumpkin – rowanberry marmalade. The experiments were carried out at the Faculty of Food Technology of the Latvia University of Agriculture. The marmalade was made from Cucurbita maxima pumpkin and sweet rowanberry Sorbus aucuparia cultivar ‘Nevezhinskaya’ pur e es. D ifferent drying times in oven at a temperature of 50 ± 2 °C were examined and compared with marmalade drying in air ambiance at room temperature. The moisture, total carotene, ascorbic acid content, hardness, colour, and the degree of acceptance of marmalade samples were determined as quality evaluation. The results of the research have shown a large variability in the physical and chemical parameters among the marmalades after different drying times. The moisture content of marmalade samples decreased by 9.1 to 33.5 %, and hardness increased from 1.85 to 9.54 N. According to sensory evaluation, consumers liked pumpkin–rowanberry marmalade samples after drying in the air ambiance at room temperature. DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3412","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"100 1","pages":"61-66"},"PeriodicalIF":0.0,"publicationDate":"2013-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88988093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-16DOI: 10.5755/J01.CT.62.4.3317
A. Sulcius, N. Žmuidzinavičienė, E. Griškonis, A. Jezerskaitė
The influence of electrolyte temperature and cathode current density on the microhardness and tensile stress of electrodeposited Mn coatings have been investigated. It has been determined that mostly hard coatings were electrodeposited from the acid manganese electrolyte with the Te(VI) additive at 20 ° C using a low current density (2 A × dm –2 ). Mn coatings of the same high hardness were electrodeposited using a higher current density (15 A × dm –2 ) and at a higher electrolyte temperature (70 ° C). S upposedly , the hardness is related to the structure and composition of coatings very closely. It has been assumed that Te incorporates in the Mn coatings during the initial stage of electrolysis and changes their structure and morphology. This leads to the maximum tensile stress values of the relatively thick coatings (1–2 m m). DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3317
研究了电解液温度和阴极电流密度对镀层显微硬度和拉伸应力的影响。在20°C下，用低电流密度(2 a × dm -2)在含Te(VI)添加剂的酸性锰电解液中电沉积了大部分硬镀层。在较高的电流密度(15 a × dm -2)和较高的电解液温度(70℃)下电沉积相同硬度的Mn涂层，硬度与涂层的结构和成分密切相关。在电解初期，Te掺杂在Mn镀层中，改变了镀层的结构和形貌。这导致相对较厚的涂层(1-2 m m)的最大拉伸应力值
{"title":"Mechanical properties of Mn coatings, electrodeposited from sulphate electrolyte with Te(VI) additive at different temperatures","authors":"A. Sulcius, N. Žmuidzinavičienė, E. Griškonis, A. Jezerskaitė","doi":"10.5755/J01.CT.62.4.3317","DOIUrl":"https://doi.org/10.5755/J01.CT.62.4.3317","url":null,"abstract":"The influence of electrolyte temperature and cathode current density on the microhardness and tensile stress of electrodeposited Mn coatings have been investigated. It has been determined that mostly hard coatings were electrodeposited from the acid manganese electrolyte with the Te(VI) additive at 20 ° C using a low current density (2 A × dm –2 ). Mn coatings of the same high hardness were electrodeposited using a higher current density (15 A × dm –2 ) and at a higher electrolyte temperature (70 ° C). S upposedly , the hardness is related to the structure and composition of coatings very closely. It has been assumed that Te incorporates in the Mn coatings during the initial stage of electrolysis and changes their structure and morphology. This leads to the maximum tensile stress values of the relatively thick coatings (1–2 m m). DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3317","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"24 1","pages":"10-15"},"PeriodicalIF":0.0,"publicationDate":"2013-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82248750","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2013-01-16DOI: 10.5755/J01.CT.62.4.3318
K. Szulc, A. Górska
The objective of the present study was to assess the influence of the drying method on selected physical properties of powdered complexes of β-lactoglobulin – cholecalciferol (β-LG – vitamin D3) with addition of carbohydrates. Improved wettability and reduced hygroscopicity were observed for β-LG – vitamin D3 complexes with addition of carbohydrates. Powdered complexes of β-LG – vitamin D3 with/without addition of lactose/trehalose obtained by freeze-drying were characterised by a larger particle size and better wettability as compared to spray-dried powders. The stability of amorphous powders depends on the material composition and storage conditions. The results showed that addition of carbohydrates, lactose or trehalose had a similar water sorption but different crystallization properties. In the case of β-LG – vitamin D3 complexes, the crystallization of carbohydrates, especially trehalose crystallization, was delayed.DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3318
{"title":"Functional properties of powdered β-lactoglobulin – cholecalciferol complexes","authors":"K. Szulc, A. Górska","doi":"10.5755/J01.CT.62.4.3318","DOIUrl":"https://doi.org/10.5755/J01.CT.62.4.3318","url":null,"abstract":"The objective of the present study was to assess the influence of the drying method on selected physical properties of powdered complexes of β-lactoglobulin – cholecalciferol (β-LG – vitamin D3) with addition of carbohydrates. Improved wettability and reduced hygroscopicity were observed for β-LG – vitamin D3 complexes with addition of carbohydrates. Powdered complexes of β-LG – vitamin D3 with/without addition of lactose/trehalose obtained by freeze-drying were characterised by a larger particle size and better wettability as compared to spray-dried powders. The stability of amorphous powders depends on the material composition and storage conditions. The results showed that addition of carbohydrates, lactose or trehalose had a similar water sorption but different crystallization properties. In the case of β-LG – vitamin D3 complexes, the crystallization of carbohydrates, especially trehalose crystallization, was delayed.DOI: http://dx.doi.org/10.5755/j01.ct.62.4.3318","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"56 1","pages":"48-51"},"PeriodicalIF":0.0,"publicationDate":"2013-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90868329","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-11-29DOI: 10.5755/J01.CT.61.3.2951
Nerijus Turskis
{"title":"Septintoji Baltijos valstybių maisto mokslo ir technologijos konferencija FOODBALT 2012","authors":"Nerijus Turskis","doi":"10.5755/J01.CT.61.3.2951","DOIUrl":"https://doi.org/10.5755/J01.CT.61.3.2951","url":null,"abstract":"","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"73 1","pages":"6-6"},"PeriodicalIF":0.0,"publicationDate":"2012-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76131239","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-11-13DOI: 10.5755/J01.CT.61.3.2847
I. Buchkevych, M. Stasevych, V. Chervetsova, R. Musyanovych, V. Novikov, V. Poroikov, T. Gloriozova, D. Filimonov, G. Zagoriy, M. Ponomarenko
Synthesis of new aminothiazole derivatives on the basis of substituted 1,4-naphthoquinones was carried out by interaction of 2-R-3,6-dichloro-7-acylamino-1,4-naphthoquinones and potassium thiocyanate, 3,6-dichloro-2,7-diacylamino-1,4-naphthoquinone and dithiocyanate, interaction of 2-R-3,6-dichloro-7-amino-1,4-naphthoquinones, 2-amino-7-nitro-3,6-dichloro-1,4-naphthoquinone and thiourea with the subsequent cyclization in aminothiazoles of 1,4-naphthoquinone. Physical and chemical properties of these compounds were determined, and the methods of their preparation are presented. Computer program PASS was used for prediction of biological activity spectra of new 1,4-naphthoquinone aminothiazole derivatives, to determine the most promising biological activities for experimental testing. Antibacterial and fungicidal activities were studied using cultures of Staphylococcus aureus , Escherichia coli and Candida tenuis microorganisms. It was found that some of the studied compounds have moderate antibacterial and fungicide activity, which in more than 90 % cases coincided with the computational predictions. Analysis of structure – antimicrobial activity relationships provides the recommendations for design of new derivatives. Some other biological activities have been predicted by PASS for these compounds, including antiviral, antineoplastic, immunomodulator, acute neurological disease treatment, antiparkinsonian, etc., which help to identify areas for further research. Thus, it was shown that 1,4-naphthoquinone aminothiazole derivatives is a promising class for preparation of novel pharmacological agents for different indications. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2847
以取代的1,4-萘醌为基础，通过2- r -3,6-二氯-2,7-二酰基氨基-1,4-萘醌与硫氰酸钾、3,6-二氯-2,7-二酰基氨基-1,4-萘醌与二硫氰酸盐、2- r -3,6-二氯-1,4-萘醌、2-氨基-7-硝基-3,6-二氯-1,4-萘醌与硫脲的相互作用，在1,4-萘醌的氨基噻唑中进行环化合成新的氨基噻唑衍生物。测定了这些化合物的理化性质，并介绍了它们的制备方法。利用计算机程序PASS对新型1,4-萘醌氨基噻唑衍生物的生物活性谱进行预测，以确定最有希望的生物活性进行实验检测。利用金黄色葡萄球菌、大肠杆菌和细念珠菌进行抑菌和杀真菌活性研究。结果发现，所研究的一些化合物具有中等的抗菌和杀真菌活性，90%以上的情况与计算预测相吻合。结构-抗菌活性关系的分析为新衍生物的设计提供了建议。通过PASS预测了这些化合物的其他生物活性，包括抗病毒、抗肿瘤、免疫调节、急性神经系统疾病治疗、抗帕金森病等，这有助于确定进一步研究的领域。因此，1,4-萘醌氨基噻唑衍生物是制备不同适应症的新型药物的一个有前途的类别。DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2847
{"title":"Synthesis, computational and antimicrobial studies of new 1,4-naphthoquinone aminothiazole derivatives","authors":"I. Buchkevych, M. Stasevych, V. Chervetsova, R. Musyanovych, V. Novikov, V. Poroikov, T. Gloriozova, D. Filimonov, G. Zagoriy, M. Ponomarenko","doi":"10.5755/J01.CT.61.3.2847","DOIUrl":"https://doi.org/10.5755/J01.CT.61.3.2847","url":null,"abstract":"Synthesis of new aminothiazole derivatives on the basis of substituted 1,4-naphthoquinones was carried out by interaction of 2-R-3,6-dichloro-7-acylamino-1,4-naphthoquinones and potassium thiocyanate, 3,6-dichloro-2,7-diacylamino-1,4-naphthoquinone and dithiocyanate, interaction of 2-R-3,6-dichloro-7-amino-1,4-naphthoquinones, 2-amino-7-nitro-3,6-dichloro-1,4-naphthoquinone and thiourea with the subsequent cyclization in aminothiazoles of 1,4-naphthoquinone. Physical and chemical properties of these compounds were determined, and the methods of their preparation are presented. Computer program PASS was used for prediction of biological activity spectra of new 1,4-naphthoquinone aminothiazole derivatives, to determine the most promising biological activities for experimental testing. Antibacterial and fungicidal activities were studied using cultures of Staphylococcus aureus , Escherichia coli and Candida tenuis microorganisms. It was found that some of the studied compounds have moderate antibacterial and fungicide activity, which in more than 90 % cases coincided with the computational predictions. Analysis of structure – antimicrobial activity relationships provides the recommendations for design of new derivatives. Some other biological activities have been predicted by PASS for these compounds, including antiviral, antineoplastic, immunomodulator, acute neurological disease treatment, antiparkinsonian, etc., which help to identify areas for further research. Thus, it was shown that 1,4-naphthoquinone aminothiazole derivatives is a promising class for preparation of novel pharmacological agents for different indications. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2847","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"64 1","pages":"62-69"},"PeriodicalIF":0.0,"publicationDate":"2012-11-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82087268","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-26DOI: 10.5755/J01.CT.61.3.2714
J. Jankauskiene, D. Jarusaitiene, V. Čeksterytė
The objective of the study was to investigate ocular changes in children and young patients with thyroid diseases before and after the treatment with 20 % honey solution eye drops. There were examined 33 patients with thyroid diseases and corneal, conjunctival changes. There were 25 girls and 8 boys. Their age was from 6 to 29.5 years. Mean age of patients was 13.2 ± 3.7 years old. 17 patients were treated with 20 % honey solution eye drops, 16 – with artificial tears (three times a day, for 3 weeks). There was evaluated the state of eye conjunctiva and cornea, visual acuity, proptosis before and after the course of treatment. All patients underwent a complete ophthalmic examination including best-corrected Snellen visual acuity, slit–lamp, corneal sensitivity investigations and Hertel exophthalmometry. The treatment with 20 % honey eye drops reduced complaints of patients (photophobia, itching, foreign body sensation, tearing and pain of the eye ball), statistically significant improved visual acuity, status of conjunctiva (redness, swelling) and cornea (fluorescein staining, corneal sensitivity and erosions) in comparison with those patients who used artificial tears. There was no change in proptosis measurements after the treatment. We have found more positive effect of 20 % honey solution eye drops on the state of the conjunctiva and cornea in patients with thyroid diseases when the treatment was started at the early period of thyroid diseases while there were no corneal damages. 20 % honey solution eye drops reduced complaints of patients, statistically significant improved visual acuity, status of conjunctiva (redness, swelling) and cornea. Honey eye drops may be used to prevent conjunctival and corneal complications in patients with thyroid diseases and corneal, conjunctival changes. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2714
{"title":"Investigation of ocular changes in children and young people with thyroid diseases before and after the treatment with 20 % honey solution eye drops","authors":"J. Jankauskiene, D. Jarusaitiene, V. Čeksterytė","doi":"10.5755/J01.CT.61.3.2714","DOIUrl":"https://doi.org/10.5755/J01.CT.61.3.2714","url":null,"abstract":"The objective of the study was to investigate ocular changes in children and young patients with thyroid diseases before and after the treatment with 20 % honey solution eye drops. There were examined 33 patients with thyroid diseases and corneal, conjunctival changes. There were 25 girls and 8 boys. Their age was from 6 to 29.5 years. Mean age of patients was 13.2 ± 3.7 years old. 17 patients were treated with 20 % honey solution eye drops, 16 – with artificial tears (three times a day, for 3 weeks). There was evaluated the state of eye conjunctiva and cornea, visual acuity, proptosis before and after the course of treatment. All patients underwent a complete ophthalmic examination including best-corrected Snellen visual acuity, slit–lamp, corneal sensitivity investigations and Hertel exophthalmometry. The treatment with 20 % honey eye drops reduced complaints of patients (photophobia, itching, foreign body sensation, tearing and pain of the eye ball), statistically significant improved visual acuity, status of conjunctiva (redness, swelling) and cornea (fluorescein staining, corneal sensitivity and erosions) in comparison with those patients who used artificial tears. There was no change in proptosis measurements after the treatment. We have found more positive effect of 20 % honey solution eye drops on the state of the conjunctiva and cornea in patients with thyroid diseases when the treatment was started at the early period of thyroid diseases while there were no corneal damages. 20 % honey solution eye drops reduced complaints of patients, statistically significant improved visual acuity, status of conjunctiva (redness, swelling) and cornea. Honey eye drops may be used to prevent conjunctival and corneal complications in patients with thyroid diseases and corneal, conjunctival changes. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2714","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"22 1","pages":"37-41"},"PeriodicalIF":0.0,"publicationDate":"2012-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73707589","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-26DOI: 10.5755/J01.CT.61.3.2710
I. Buchovec, R. Kokstaite, Ž. Lukšienė
The aim of this study was to evaluate antimicrobial efficiency of photoactivated chlorophyllin-chitozan complex against food pathogen Salmonella enterica . Salmonella enterica was used for experiments. Aliquots of bacterial suspensions (~1×10 7 CFU/ml in 0.9 % NaCl) with 0.001 % chlorophyllin-0.1 % chitosan complex (Chl-CHS) were incubated in the dark at 37 °C for 0–120 min. For the photoactivation, the samples were exposed to light ( λ = 405 nm) for 30 min (light dose 17.3 J/cm 2 ). Microbial viability was evaluated by spread plate method. Chl-based photosensitization treatment reduced the bacterial population by 1.39 log. Extremely high antibacterial efficiency was demonstrated after photoactivation of Chl-CHS complex (7.3 log reduction of microbial population). Experimental data support the idea that photoactivated CHS-Chl complex in slightly acidic environment can be a useful tool against Gram (-) bacteria S. enterica .. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2710
{"title":"Antimicrobial Efficiency of Photoactivated Chlorophyllin-Chitosan Complex","authors":"I. Buchovec, R. Kokstaite, Ž. Lukšienė","doi":"10.5755/J01.CT.61.3.2710","DOIUrl":"https://doi.org/10.5755/J01.CT.61.3.2710","url":null,"abstract":"The aim of this study was to evaluate antimicrobial efficiency of photoactivated chlorophyllin-chitozan complex against food pathogen Salmonella enterica . Salmonella enterica was used for experiments. Aliquots of bacterial suspensions (~1×10 7 CFU/ml in 0.9 % NaCl) with 0.001 % chlorophyllin-0.1 % chitosan complex (Chl-CHS) were incubated in the dark at 37 °C for 0–120 min. For the photoactivation, the samples were exposed to light ( λ = 405 nm) for 30 min (light dose 17.3 J/cm 2 ). Microbial viability was evaluated by spread plate method. Chl-based photosensitization treatment reduced the bacterial population by 1.39 log. Extremely high antibacterial efficiency was demonstrated after photoactivation of Chl-CHS complex (7.3 log reduction of microbial population). Experimental data support the idea that photoactivated CHS-Chl complex in slightly acidic environment can be a useful tool against Gram (-) bacteria S. enterica .. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2710","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"9 1","pages":"54-57"},"PeriodicalIF":0.0,"publicationDate":"2012-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90588507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2012-10-26DOI: 10.5755/J01.CT.61.3.2717
J. Krzyczkowska
The study investigated the ability of the strain of Yarrowia lipolytica KKP 379 to gamma-decalactone production by biotransformation of castor oil. The content of gamma-decalactone was verified in the water and lipid phase within 7 days of reaction. On the basis of granulometric analysis, the characteristic of the emulsion was presented. The results confirmed the ability of strain Y. lipolytica 379 KKP to produce gamma-decalactone in the amount of about 1.68 g/l. The granulometric analysis revealed two populations of fatty droplets with size of 4.5 μm and 580 μm. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2717
{"title":"The use of castor oil in the production of gamma-decalactone by Yarrowia lipolytica KKP 379","authors":"J. Krzyczkowska","doi":"10.5755/J01.CT.61.3.2717","DOIUrl":"https://doi.org/10.5755/J01.CT.61.3.2717","url":null,"abstract":"The study investigated the ability of the strain of Yarrowia lipolytica KKP 379 to gamma-decalactone production by biotransformation of castor oil. The content of gamma-decalactone was verified in the water and lipid phase within 7 days of reaction. On the basis of granulometric analysis, the characteristic of the emulsion was presented. The results confirmed the ability of strain Y. lipolytica 379 KKP to produce gamma-decalactone in the amount of about 1.68 g/l. The granulometric analysis revealed two populations of fatty droplets with size of 4.5 μm and 580 μm. DOI: http://dx.doi.org/10.5755/j01.ct.61.3.2717","PeriodicalId":22505,"journal":{"name":"the Chemical Technology","volume":"30 1","pages":"58-61"},"PeriodicalIF":0.0,"publicationDate":"2012-10-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81691640","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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