Background: Irritable bowel syndrome is a functional disorder with recurrent abdominal discomfort associated with abnormalities in gut motility. One of the risk factors for IBS is anxiety and depression. This study aims to find out the relationship between medical student’s psychosocial conditions, measured by depression and anxiety with incidence of IBS. Gastrointestinal-specific anxiety (GSA), a subset of general anxiety, is measured and its relationship with incidence of IBS is also evaluated.Method: This research is a cross sectional study. Sample consists of 168 medical students from UPH batch 2016-2018 that fits into inclusion and exclusion criteria. Data is collected with demographics questionnaire, Rome IV IBS Criteria, Depression, Anxiety and Stress Scale 21, and Visceral Sensitivity Index. Categorical data between depression and anxiety and IBS is analyzed with Chi Square. GSA is a numerical data and its relationship with IBS is analyzed with t-test. Because GSA All statistical data is analyzed using SPSS version 22.0.Results: Results showed that from 168 samples that are acquired for this research, 65 (38,7%) are IBS and 103 (61,3%) are non-IBS. Significant associations are found between depression (p=0,03), anxiety (p=0,039), gastrointestinal-specific anxiety (p0,001), and obesity (p=0,026) with incidence of IBS.Conclusion: There is a significant association between depression and anxiety with incidence of IBS.
{"title":"Relationship Between Psychological Distress and Irritable Bowel Syndrome (IBS) in Medical Students of Pelita Harapan University","authors":"S. Nanda, V. Sungono","doi":"10.24871/2132020199-206","DOIUrl":"https://doi.org/10.24871/2132020199-206","url":null,"abstract":"Background: Irritable bowel syndrome is a functional disorder with recurrent abdominal discomfort associated with abnormalities in gut motility. One of the risk factors for IBS is anxiety and depression. This study aims to find out the relationship between medical student’s psychosocial conditions, measured by depression and anxiety with incidence of IBS. Gastrointestinal-specific anxiety (GSA), a subset of general anxiety, is measured and its relationship with incidence of IBS is also evaluated.Method: This research is a cross sectional study. Sample consists of 168 medical students from UPH batch 2016-2018 that fits into inclusion and exclusion criteria. Data is collected with demographics questionnaire, Rome IV IBS Criteria, Depression, Anxiety and Stress Scale 21, and Visceral Sensitivity Index. Categorical data between depression and anxiety and IBS is analyzed with Chi Square. GSA is a numerical data and its relationship with IBS is analyzed with t-test. Because GSA All statistical data is analyzed using SPSS version 22.0.Results: Results showed that from 168 samples that are acquired for this research, 65 (38,7%) are IBS and 103 (61,3%) are non-IBS. Significant associations are found between depression (p=0,03), anxiety (p=0,039), gastrointestinal-specific anxiety (p0,001), and obesity (p=0,026) with incidence of IBS.Conclusion: There is a significant association between depression and anxiety with incidence of IBS.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"5 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"75974118","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: GeneXpert has been used for Mycobacterium tuberculosis testing, but is currently available for HCV RNA testing. GeneXpert assay is expected to be more accurate, efficient, and cost-effective for HCV viral load quantification. This study intended to evaluate the new method quantification of plasma HCV RNA by the GeneXpert in comparison to the Roche Cobas TaqMan 96 as standard diagnostic tools.Method: A total of 54 HCV-infected plasma samples with anti-HCV positive were examined by GeneXpert assay, followed with Cobas TaqMan 96 for quantification of HCV RNA. Correlation was performed by Pearson test (in log10) and diagnostic test by Chi-square test. Sensitivity and specificity of the GeneXpert assay measured by calculating 2x2 contingency table. Bland-Altman plot were generated to assess the mean difference between the two assays.Results: GeneXpert has strong correlation to the Roche Cobas TaqMan 96 (R=0.993; P value 0.001). GeneXpert has sensitivity of 100% (95% CI: 90–100%) and specificity of 90% (95% CI: 54.1–99.5%). The Bland Altmand plot showed that one sampel has 1 log difference with the Roche Cobas TaqMan 96 measurement result.Conclusion: There was a strong correlation in the measurement of HCV RNA by GeneXpert and moreover its assay also has an excellent overall performance compared to Cobas TaqMan 96. Thus, it can be considered as a reliable tools for HCV virological response monitoring.
{"title":"Evaluation of GeneXpert for Quantification Viral Load Hepatitis C Virus","authors":"C. Jasirwan, I. Hasan, A. Sulaiman, R. Gani","doi":"10.24871/2132020182-187","DOIUrl":"https://doi.org/10.24871/2132020182-187","url":null,"abstract":"Background: GeneXpert has been used for Mycobacterium tuberculosis testing, but is currently available for HCV RNA testing. GeneXpert assay is expected to be more accurate, efficient, and cost-effective for HCV viral load quantification. This study intended to evaluate the new method quantification of plasma HCV RNA by the GeneXpert in comparison to the Roche Cobas TaqMan 96 as standard diagnostic tools.Method: A total of 54 HCV-infected plasma samples with anti-HCV positive were examined by GeneXpert assay, followed with Cobas TaqMan 96 for quantification of HCV RNA. Correlation was performed by Pearson test (in log10) and diagnostic test by Chi-square test. Sensitivity and specificity of the GeneXpert assay measured by calculating 2x2 contingency table. Bland-Altman plot were generated to assess the mean difference between the two assays.Results: GeneXpert has strong correlation to the Roche Cobas TaqMan 96 (R=0.993; P value 0.001). GeneXpert has sensitivity of 100% (95% CI: 90–100%) and specificity of 90% (95% CI: 54.1–99.5%). The Bland Altmand plot showed that one sampel has 1 log difference with the Roche Cobas TaqMan 96 measurement result.Conclusion: There was a strong correlation in the measurement of HCV RNA by GeneXpert and moreover its assay also has an excellent overall performance compared to Cobas TaqMan 96. Thus, it can be considered as a reliable tools for HCV virological response monitoring.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83233317","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Background: Percutaneous endoscopic gastrostomy (PEG) facilitates long-term enteral nutrition. However, parenteral nutrition prior to PEG tube placement can cause impaired gastrointestinal function. Additionally, upon initiation of enteral feeding via a PEG tube, some patients suffer from gastrointestinal symptoms (e.g., vomiting, diarrhea), which reduce their quality of life and increase the nursing workload. Method: This retrospective study included 155 patients upon whom the author performed PEG as the attending physician. Enteral nutrition was started through the PEG tube on the third day after its placement. The following characteristics were analyzed: age, gender, indications for PEG, preoperative enteral nutrition, administered liquid nutrients, daily dosage of nutrients, serum albumin levels, serum alanine aminotransferase levels, serum creatinine levels, serum hemoglobin levels, and vomiting or diarrhea within seven days after the initiation of PEG feeding. A logistic regression model was used to identify the risk factors contributing to gastrointestinal symptoms, and three variables were sequentially introduced into the model—preoperative non-enteral nutrition, hypoalbuminemia, and administration of non-elemental diets. Results: Vomiting and diarrhea occurred in 10 and 15 patients, respectively. There were significant differences in administered nutrients and serum albumin levels between patients with and without gastrointestinal symptoms. Multivariate analysis revealed that the adjusted odds ratios for administration of non-elemental diets and serum albumin level ≤3.2 g/dL were 8.05 (95% confidence interval (CI): 2.66–24.4; p < 0.001) and 3.81 (95% CI: 1.33–10.9; p < 0.05), respectively. Conclusion: The administration of non-elemental diets and a serum albumin level ≤3.2 g/dL were significant risk factors.
{"title":"Risk Factors for Gastrointestinal Symptoms post Enteral Nutrition Initiation via a Gastrostomy Tube","authors":"Y. Kajihara","doi":"10.24871/2132020207-211","DOIUrl":"https://doi.org/10.24871/2132020207-211","url":null,"abstract":"Background: Percutaneous endoscopic gastrostomy (PEG) facilitates long-term enteral nutrition. However, parenteral nutrition prior to PEG tube placement can cause impaired gastrointestinal function. Additionally, upon initiation of enteral feeding via a PEG tube, some patients suffer from gastrointestinal symptoms (e.g., vomiting, diarrhea), which reduce their quality of life and increase the nursing workload. Method: This retrospective study included 155 patients upon whom the author performed PEG as the attending physician. Enteral nutrition was started through the PEG tube on the third day after its placement. The following characteristics were analyzed: age, gender, indications for PEG, preoperative enteral nutrition, administered liquid nutrients, daily dosage of nutrients, serum albumin levels, serum alanine aminotransferase levels, serum creatinine levels, serum hemoglobin levels, and vomiting or diarrhea within seven days after the initiation of PEG feeding. A logistic regression model was used to identify the risk factors contributing to gastrointestinal symptoms, and three variables were sequentially introduced into the model—preoperative non-enteral nutrition, hypoalbuminemia, and administration of non-elemental diets. Results: Vomiting and diarrhea occurred in 10 and 15 patients, respectively. There were significant differences in administered nutrients and serum albumin levels between patients with and without gastrointestinal symptoms. Multivariate analysis revealed that the adjusted odds ratios for administration of non-elemental diets and serum albumin level ≤3.2 g/dL were 8.05 (95% confidence interval (CI): 2.66–24.4; p < 0.001) and 3.81 (95% CI: 1.33–10.9; p < 0.05), respectively. Conclusion: The administration of non-elemental diets and a serum albumin level ≤3.2 g/dL were significant risk factors.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"21 1","pages":"207-211"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"41666856","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
R. Adiwinata, Linda Rotty, M. Tendean, B. J. Waleleng, Fandy Gosal, Luciana Rotty, Jeanne Winarta, Andrew Waleleng
Colorectal cancer patient may present with variable clinical presentation. In few cases, colorectal cancer may present as emergency such as uncontrollable gastrointestinal bleeding, large bowel obstruction and in rarer fashion is bowel perforation. Worse prognosis is linked with emergency presenting colorectal cancer. Peritoneal carcinomatosis may occur in 10-35% of colorectal cancer patients and may develop bowel obstruction along with the primary colorectal cancer. Here, we report a-62-year-old man presented with large bowel obstruction leading to perforation without known history of colorectal cancer before. On emergency laparotomy, we found colorectal cancer and peritoneal carcinomatosis as the underlying cause. Prompt diagnosis and urgent management is warranted to improve the prognosis.
{"title":"Bowel Obstruction and Perforation as Emergency Presenting Sign of Colorectal Cancer with Peritoneal Carcinomatosis: A Case Report and Review","authors":"R. Adiwinata, Linda Rotty, M. Tendean, B. J. Waleleng, Fandy Gosal, Luciana Rotty, Jeanne Winarta, Andrew Waleleng","doi":"10.24871/2132020235-240","DOIUrl":"https://doi.org/10.24871/2132020235-240","url":null,"abstract":"Colorectal cancer patient may present with variable clinical presentation. In few cases, colorectal cancer may present as emergency such as uncontrollable gastrointestinal bleeding, large bowel obstruction and in rarer fashion is bowel perforation. Worse prognosis is linked with emergency presenting colorectal cancer. Peritoneal carcinomatosis may occur in 10-35% of colorectal cancer patients and may develop bowel obstruction along with the primary colorectal cancer. Here, we report a-62-year-old man presented with large bowel obstruction leading to perforation without known history of colorectal cancer before. On emergency laparotomy, we found colorectal cancer and peritoneal carcinomatosis as the underlying cause. Prompt diagnosis and urgent management is warranted to improve the prognosis.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83105978","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The Role of GERD Questionnaire (GERD-Q) for Reflux Esophagitis","authors":"Kaka Renaldi","doi":"10.24871/2132020169-170","DOIUrl":"https://doi.org/10.24871/2132020169-170","url":null,"abstract":"<jats:p>-</jats:p>","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82999343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Constipation is a gastrointestinal disorder commonly found in the community, especially in the elderly with various comorbidities. This problem culminates with the increasing incidence along with aging, increasing therapeutic cost, and decreasing the quality of life in this population. Some of the underlying causes are the difference in the terminology of constipation, shallow understanding of its pathophysiology, and poor management. The pathophysiology, including slow transit constipation, dyssynergic defecation, and normal transit constipation, is the most critical foundation in managing constipation accordingly. Diagnostic approaches should be made by history taking, including complaints based on Rome III, lifestyle, contributing factors, past medical history, and medications. Physical examination is considered incomplete without rectal examination. Thorough history taking and comprehensive physical examination have more diagnostic value than additional physiological workup. Management of constipation consists of non-pharmacological and pharmacological approaches, such as conventional laxative or more recent agents with better efficacy. Therapeutical management should correspond to the underlying pathophysiology. Therefore it is important to be able to recognize constipation and make the right management approach in the elderly.
{"title":"Constipation in Elderly Population and Its Appropriate Management","authors":"A. Kurniawan, Ulfa Kholili, Novira Widajanti","doi":"10.24871/2132020212-219","DOIUrl":"https://doi.org/10.24871/2132020212-219","url":null,"abstract":"Constipation is a gastrointestinal disorder commonly found in the community, especially in the elderly with various comorbidities. This problem culminates with the increasing incidence along with aging, increasing therapeutic cost, and decreasing the quality of life in this population. Some of the underlying causes are the difference in the terminology of constipation, shallow understanding of its pathophysiology, and poor management. The pathophysiology, including slow transit constipation, dyssynergic defecation, and normal transit constipation, is the most critical foundation in managing constipation accordingly. Diagnostic approaches should be made by history taking, including complaints based on Rome III, lifestyle, contributing factors, past medical history, and medications. Physical examination is considered incomplete without rectal examination. Thorough history taking and comprehensive physical examination have more diagnostic value than additional physiological workup. Management of constipation consists of non-pharmacological and pharmacological approaches, such as conventional laxative or more recent agents with better efficacy. Therapeutical management should correspond to the underlying pathophysiology. Therefore it is important to be able to recognize constipation and make the right management approach in the elderly.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"85 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73420949","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Iron deficiency anemia can be the first manifestation of colon cancer. However, iron deficiency anemia is also common in other benign conditions, which may cause a longer delay for referral decisions to get a definitive diagnosis. This is a case of 40-year-old male patient who had only iron deficiency anemia as a manifestation of colon cancer. Colonoscopy revealed intraluminal mass in transverse colon. After resection of the tumor, histopathology showed well-differentiated mucinous adenocarcinoma, invasion of sub-serous, and one node positive (pT3pN1pM0). After resection, we administered XELOX as adjuvant chemotherapy every 3 weeks for 8 cycles.
{"title":"Iron Deficiency Anemia as The Only Manifestation of Colon Cancer in Male Patient: A Case Report","authors":"W. Rajabto, P. T. Sakti, Andi Putra Kevinsyah","doi":"10.24871/2132020241-243","DOIUrl":"https://doi.org/10.24871/2132020241-243","url":null,"abstract":"Iron deficiency anemia can be the first manifestation of colon cancer. However, iron deficiency anemia is also common in other benign conditions, which may cause a longer delay for referral decisions to get a definitive diagnosis. This is a case of 40-year-old male patient who had only iron deficiency anemia as a manifestation of colon cancer. Colonoscopy revealed intraluminal mass in transverse colon. After resection of the tumor, histopathology showed well-differentiated mucinous adenocarcinoma, invasion of sub-serous, and one node positive (pT3pN1pM0). After resection, we administered XELOX as adjuvant chemotherapy every 3 weeks for 8 cycles.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"86942992","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
L. Rotty, Nelly Tendean, Nancy Lestari, R. Adiwinata
Background: Obesity had become a global problem today. Obesity is a significant risk factor of cardiovascular and other metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). It remains unclear if the increased mean platelet volume (MPV) at the steatosis state is practicable as early detection of the occurrence of fatty liver in individuals with central obesity. This study aims to determine the association of interleukin-6 (IL-6) and MPV levels in central obesity with or without NAFLD. Method: This study was descriptive-analytic with a cross-sectional approach conducted in Prof. dr. R. D. Kandou Manado general hospital from May to July 2018. Consecutive sampling was performed based on inclusion criteria, then IL-6, MPV, and abdominal ultrasound examinations were performed. Results: This study included 40 samples of men with central obesity, 28 people (70%) among them were diagnosed with NAFLD. The Fisher exact test showed an association between NAFLD and an increase in IL-6 (p = 0.039), also between MPV and NAFLD (p=0.015). Pearson correlation test showed there was no significant correlation between IL-6 and MPV in the NAFLD sample group (p = 0.084; r -0.332) and in the non-NAFLD sample group (p = 0.564; r -0.186). Conclusion : Elevated MPV and IL-6 values may be used as marker for NAFLD presence among central obesity patients.
{"title":"The Association between Interleukin-6 and Mean Platelet Volume Levels in Central Obesity with or without Non-Alcoholic Fatty Liver Disease","authors":"L. Rotty, Nelly Tendean, Nancy Lestari, R. Adiwinata","doi":"10.24871/2132020193-198","DOIUrl":"https://doi.org/10.24871/2132020193-198","url":null,"abstract":"Background: Obesity had become a global problem today. Obesity is a significant risk factor of cardiovascular and other metabolic diseases such as non-alcoholic fatty liver disease (NAFLD). It remains unclear if the increased mean platelet volume (MPV) at the steatosis state is practicable as early detection of the occurrence of fatty liver in individuals with central obesity. This study aims to determine the association of interleukin-6 (IL-6) and MPV levels in central obesity with or without NAFLD. Method: This study was descriptive-analytic with a cross-sectional approach conducted in Prof. dr. R. D. Kandou Manado general hospital from May to July 2018. Consecutive sampling was performed based on inclusion criteria, then IL-6, MPV, and abdominal ultrasound examinations were performed. Results: This study included 40 samples of men with central obesity, 28 people (70%) among them were diagnosed with NAFLD. The Fisher exact test showed an association between NAFLD and an increase in IL-6 (p = 0.039), also between MPV and NAFLD (p=0.015). Pearson correlation test showed there was no significant correlation between IL-6 and MPV in the NAFLD sample group (p = 0.084; r -0.332) and in the non-NAFLD sample group (p = 0.564; r -0.186). Conclusion : Elevated MPV and IL-6 values may be used as marker for NAFLD presence among central obesity patients.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"21 1","pages":"193-198"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"48404707","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A. Sulaiman, Juferdy Kurniawan, C. Jasirwan, Saut Nababan, Kemal F Calista, C. Lesmana, I. Hasan, R. Gani, B. K. D. Mandasari
By late December 2019, a novel beta-coronavirus, named as COVID-19 (2019-nCoV), was discovered in Wuhan, Hubei Province, China which epidemiologically linked to a Huanan seafood market in Wuhan. Coronavirus Disease 2019 or COVID-19 cases are growing rapidly from Wuhan to many countries, finding the health care system unprepared to face this threat. No effective drugs are clinically approved to manage the disease and strategies to protect the most vulnerable from developing severe illness and infection is still unclear. Information on how COVID-19 virus infection may affects many organs, especially the liver and the relevance of pre-existing liver disease in patients as a risk factor for the infection or disease severity are still scarce and inconclusive. Besides, the recommendation and consideration in liver transplant patients, hepatocellular carcinoma, or patient on immunosuppressive therapy still need further analysis Therefore, the information on the mechanism and treatment of COVID-19 related liver injury in patients with or without pre-existing liver disease should be considered.
{"title":"COVID-19 Related to Liver Impairment and Its Impact on Chronic Liver Disease","authors":"A. Sulaiman, Juferdy Kurniawan, C. Jasirwan, Saut Nababan, Kemal F Calista, C. Lesmana, I. Hasan, R. Gani, B. K. D. Mandasari","doi":"10.24871/2132020220-225","DOIUrl":"https://doi.org/10.24871/2132020220-225","url":null,"abstract":"By late December 2019, a novel beta-coronavirus, named as COVID-19 (2019-nCoV), was discovered in Wuhan, Hubei Province, China which epidemiologically linked to a Huanan seafood market in Wuhan. Coronavirus Disease 2019 or COVID-19 cases are growing rapidly from Wuhan to many countries, finding the health care system unprepared to face this threat. No effective drugs are clinically approved to manage the disease and strategies to protect the most vulnerable from developing severe illness and infection is still unclear. Information on how COVID-19 virus infection may affects many organs, especially the liver and the relevance of pre-existing liver disease in patients as a risk factor for the infection or disease severity are still scarce and inconclusive. Besides, the recommendation and consideration in liver transplant patients, hepatocellular carcinoma, or patient on immunosuppressive therapy still need further analysis Therefore, the information on the mechanism and treatment of COVID-19 related liver injury in patients with or without pre-existing liver disease should be considered.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88930037","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Husna Yetti, Nada Utami Prahastiwi, R. Susanti, E. Decroli, Saptino Miro
Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as chronic liver disease, both in developed and developing countries. NAFLD affects up to 25% population worldwide. The incidence of NAFLD associated with various risk factors supporting the development of the fatty liver. This study aim is to know the characteristics of NAFLD patients. Method: Retrospective study was conducted from medical records to find the characteristics of patients diagnosed with NAFLD at Dr. M. Djamil General Hospital from January 2016 – December 2018. Results: Seventy-seven patients were diagnosed with NAFLD. The majority of NAFLD patients were male and female at 36-45 years old and female at > 65 years old. Unemployed females were more prevalent compared to males. Dyslipidemia was the most component of a metabolic syndrome found in NAFLD patients. From laboratory findings, 55.56% of patients have increased aspartate aminotransferase (AST) levels, while 52.78% have increased alanine aminotransferase (ALT) levels. Ultrasonography used widely as a diagnostic device to detect NAFLD. Pharmacological therapy based on American Asociation for the Study of Liver Disease (AASLD) recommendation that used widely to treat patients with NAFLD was statin. Conclusion: The incidence of NAFLD was found to vary in different age ranges and sexes. Dyslipidemia occurred in most of NAFLD patients. AST and ALT levels increased in about half of the patients. Abdomen ultrasound as a diagnostic modality that was widely used.
背景:在发达国家和发展中国家，非酒精性脂肪性肝病(NAFLD)正在成为一种慢性肝病。NAFLD影响全球高达25%的人口。NAFLD的发病率与支持脂肪肝发展的各种危险因素相关。本研究旨在了解NAFLD患者的特点。方法:回顾性研究2016年1月至2018年12月Dr. M. Djamil总医院诊断为NAFLD患者的病历特征。结果:77例患者确诊为NAFLD。NAFLD患者以36-45岁的男性和女性居多，年龄在55 - 65岁的女性居多。与男性相比，女性失业更为普遍。血脂异常是NAFLD患者代谢综合征的最主要组成部分。实验室结果显示，55.56%的患者有天冬氨酸转氨酶(AST)升高，52.78%的患者有丙氨酸转氨酶(ALT)升高。超声检查被广泛用于NAFLD的诊断。根据美国肝病研究协会(AASLD)的推荐，他汀类药物被广泛用于治疗NAFLD患者。结论:NAFLD的发病率在不同年龄段和性别之间存在差异。大多数NAFLD患者出现血脂异常。大约一半的患者AST和ALT水平升高。腹部超声作为一种诊断方式被广泛应用。
{"title":"Characteristics of Non-Alcoholic Fatty Liver Disease Patients at Dr. M. Djamil General Hospital Padang","authors":"Husna Yetti, Nada Utami Prahastiwi, R. Susanti, E. Decroli, Saptino Miro","doi":"10.24871/2132020171-176","DOIUrl":"https://doi.org/10.24871/2132020171-176","url":null,"abstract":"Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is emerging as chronic liver disease, both in developed and developing countries. NAFLD affects up to 25% population worldwide. The incidence of NAFLD associated with various risk factors supporting the development of the fatty liver. This study aim is to know the characteristics of NAFLD patients. Method: Retrospective study was conducted from medical records to find the characteristics of patients diagnosed with NAFLD at Dr. M. Djamil General Hospital from January 2016 – December 2018. Results: Seventy-seven patients were diagnosed with NAFLD. The majority of NAFLD patients were male and female at 36-45 years old and female at > 65 years old. Unemployed females were more prevalent compared to males. Dyslipidemia was the most component of a metabolic syndrome found in NAFLD patients. From laboratory findings, 55.56% of patients have increased aspartate aminotransferase (AST) levels, while 52.78% have increased alanine aminotransferase (ALT) levels. Ultrasonography used widely as a diagnostic device to detect NAFLD. Pharmacological therapy based on American Asociation for the Study of Liver Disease (AASLD) recommendation that used widely to treat patients with NAFLD was statin. Conclusion: The incidence of NAFLD was found to vary in different age ranges and sexes. Dyslipidemia occurred in most of NAFLD patients. AST and ALT levels increased in about half of the patients. Abdomen ultrasound as a diagnostic modality that was widely used.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"21 1","pages":"171-176"},"PeriodicalIF":0.0,"publicationDate":"2020-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"43543278","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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