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The Correlation Between Coffee Consumption and Gastroesophageal Reflux Disease 喝咖啡与胃食管反流病的关系
Farrell Z R Hartoyo, K. Tandarto, V. Sidharta, Riki Tenggara
Background: Gastroesophageal reflux disease or commonly known as GERD is a condition when the stomach’s contents rise into the esophagus This condition causes symptoms and complications. It was found that 57.6% of the Indonesian population had GERD. Coffee is the most popular beverage in the world. Coffee consumption is suspected of having a close relationship with GERD incidence. This study aims to determine the correlation between coffee consumption and the incidence gastroesophageal reflux disease (GERD).Method: This study used a cross-sectional approach to conduct observational analytics research. This study sample consisted of every person aged 18 – 65 years  in Jakarta. Study data were obtained through the Gastroesophageal Reflux Disease Questionnaire (GERD-Q) in Indonesian languange. The Chi-square of independence test was used to determine the correlation between coffee consumption and gastroesophageal reflux disease (GERD).Results: From 105 respondents, 26 respondents experience GERD. Eighty-four point six percent of respondents that experience GERD consumed coffee in moderate to high levels of frequency, and 15.3% of respondents that experience GERD consumed coffee in none to fewer levels of frequency. Chi-square test results showed a significant correlation between coffee consumption and GERD in every Jakartan’s people aged 18 – 65 years (p = 0,006).Conclusion: There is a significant correlation between coffee consumption and  Gastroesophageal reflux disease (GERD) in people aged 18 – 65 years old that live in Jakarta.
背景:胃食管反流病或通常称为GERD是一种胃内容物上升到食道的情况,这种情况会引起症状和并发症。研究发现,印尼人口中有57.6%患有胃食管反流。咖啡是世界上最受欢迎的饮料。人们怀疑喝咖啡与胃反流的发生有密切关系。本研究旨在确定咖啡摄入量与胃食管反流病(GERD)发病率之间的相关性。方法:本研究采用横断面方法进行观察分析研究。该研究样本包括雅加达18 - 65岁的所有人。研究数据通过印尼语胃食管反流疾病问卷(GERD-Q)获得。采用独立卡方检验确定咖啡摄入与胃食管反流病(GERD)之间的相关性。结果:105名受访者中,26名受访者经历过胃食管反流。86.6%经历过胃食管反流的受访者饮用咖啡的频率从中等到高,15.3%经历过胃食管反流的受访者饮用咖啡的频率从零到低。卡方检验结果显示,在所有雅加达18 - 65岁人群中,咖啡摄入量与胃食管反流症之间存在显著相关性(p = 0.006)。结论:雅加达18 - 65岁人群饮用咖啡与胃食管反流病(GERD)之间存在显著相关性。
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引用次数: 0
Treatment for Intermediate-Stage Hepatocellular Carcinoma: Current Practice and Outcome in Real World Study 中期肝细胞癌的治疗:现实世界研究的当前实践和结果
I. Hasan, I. Loho, C. Lesmana, R. Gani, Lianda Siregar, A. Waspodo, L. Lesmana
Background: Intermediate-stage hepatocellular carcinoma (HCC) is a very heterogeneous disease. The first line treatment for this group is transarterial chemoembolization (TACE), however, in clinical practice, not all patients are suitable for TACE. We aim to evaluate current treatment practice and outcome of patients with intermediate-stage HCC.Methods: HCC patients database from 2013 to 2016 in Cipto Mangunkusumo Hospital and Dharmais Cancer Hospital were retrospectively analyzed. Patients with intermediate-stage HCC were included in this study.Results: A total of 456 patients were diagnosed with HCC, but only 151 (33.1%) patients with intermediate-stage HCC were included. Men outnumbered women in a ratio of 3:1. The most common etiology for HCC was hepatitis B virus (HBV) infection, which accounted for 55% of patients. Fifty-two patients (34.4%) were treated with TACE as first-line treatment. Sixty-seven patients (44%) were given best supportive care due to ineligibility for TACE. Frequency of TACE varied from one to eleven times. Overall median survival was 617 days (1.7 years). One-year survival for patients undergoing TACE and liver resection was 47% and 60%, respectively. We did not compare the survival between any treatment groups because the number of patient in each group is not sufficient to be statistically analyzed.Conclusion: Only 34.4% of patients with intermediate-stage HCC was treated with TACE as first-line treatment. An improvement in the treatment strategy should be done for HCC patients in Indonesia.
背景:中期肝细胞癌(HCC)是一种异质性很强的疾病。该组的一线治疗是经动脉化疗栓塞(TACE),但在临床实践中,并非所有患者都适合进行TACE。我们的目的是评估目前的治疗实践和中期HCC患者的结果。方法:回顾性分析2013 - 2016年Cipto Mangunkusumo医院和Dharmais肿瘤医院HCC患者数据库。本研究纳入了中期HCC患者。结果:共456例患者被诊断为HCC,但仅151例(33.1%)为中期HCC。男女比例为3:1。HCC最常见的病因是乙型肝炎病毒(HBV)感染,占患者的55%。52例(34.4%)患者接受TACE作为一线治疗。67例(44%)患者因不适合TACE而获得最佳支持治疗。TACE的频率从1次到11次不等。总中位生存期为617天(1.7年)。接受TACE和肝切除术的患者一年生存率分别为47%和60%。我们没有比较任何治疗组之间的生存率,因为每组患者的数量不足以进行统计分析。结论:TACE作为一线治疗方案的中期HCC患者仅占34.4%。印度尼西亚HCC患者的治疗策略应该有所改进。
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引用次数: 1
Clinical Practice in Intermediate Hepatocellular Carcinoma in the Real World 现实世界中中级肝细胞癌的临床实践
C. Jasirwan
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引用次数: 0
A Case of Thyrotoxic Periodic Paralysis and Graves’ Ophthalmopathy Patient in Coincidence with Chronic Hepatitis B Infection 慢性乙型肝炎合并甲状腺毒性周期性麻痹和Graves眼病1例
H. K. Ginting, S. Adi
Graves' disease is an autoimmune thyroid disease with several characteristic symptoms and signs. Graves' ophthalmopathy, an inflammatory disease in the orbital area, is the main extrathyroid manifestation of Graves' disease. About 5% of Graves' ophthalmopathy patients have moderate to severe severity requiring high doses of systemic corticosteroid therapy. Graves' disease also has few complications, one of which is thyrotoxic periodic paralytic characterized by hypokalemia and muscle paralysis. Chronic hepatitis B virus infection has the potential to be co-incidence with other diseases (eg Graves ophthalmopathy). The need of high dose of corticosteroid therapy in treating Graves’ ophthalmopathy is a risk of reactivation in hepatitis B infection patient. This paper presented a Graves' disease patient complicated with Graves’ ophthalmopathy who developed limb muscle weakness. Patient will receive high doses of corticosteroids and prophylactic lamivudine therapy to prevent hepatitis B virus reactivation.
格雷夫斯病是一种自身免疫性甲状腺疾病,具有几种特征性症状和体征。Graves眼病是眼眶内的一种炎性疾病,是Graves病的主要甲状腺外表现。约5%的Graves眼病患者有中度至重度,需要大剂量的全身皮质类固醇治疗。Graves病的并发症也很少,其中之一是甲状腺毒性周期性麻痹,以低钾血症和肌肉麻痹为特征。慢性乙型肝炎病毒感染有可能与其他疾病(如格雷夫斯眼病)同时发病。乙型肝炎感染患者治疗Graves眼病需要大剂量皮质类固醇治疗,存在再激活的风险。本文报道一例Graves病合并Graves眼病并发肢体肌无力的病例。患者将接受高剂量皮质类固醇和预防性拉米夫定治疗,以防止乙型肝炎病毒再激活。
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引用次数: 0
The Effectiveness of a High-Protein Liquid Dietary Supplementation in Improving Nutritional Status of Malnourished Patients in Hospital Care: a Preliminary Study 高蛋白液体膳食补充剂改善医院护理中营养不良患者营养状况的有效性:一项初步研究
M. Simadibrata, M. Abdullah, F. Witjaksono, V. N. Muzellina, A. P. Utari, Y. Wulandari, Ari Wijayanti, Dewi Mustikarani, Raja Mangatur Haloho, Aditya Rachman, D. M. Simadibrata, Rizka Mutiara, Kaka Renaldi
Background: Malnutrition is a very common problem in hospitalized patients. Based on studies conducted in various countries, the prevalence of hospital malnutrition ranges from 20-45%. Hospital malnutrition can occur as a result of insufficient nutrient intake, impaired absorption of nutrients in the gastrointestinal (GI) tract, loss of nutrients due to disease, or increased metabolic requirement during illness. Nutrition is the basis for the healing process as it requires good nutrients through various enzymatic reactions. Some studies have shown that hospital malnutrition increases morbidity, mortality, prolongs the duration of hospitalization, and delays recovery. To improve nutritional status, a high-protein diet can be given. Liquid diet is one of the alternative forms of nutrition because it is easier to swallow.Method: This study was a double-blind randomized controlled trial conducted to assess the effectiveness of high protein liquid dietary supplementation in malnourished hospitalized patients. The patients were assessed for their nutritional status based on ESPEN 2015 criteria. Patients who experienced malnutrition will be divided into 2 groups, namely the control group which was given normal protein liquid diet, while the intervention group was given high protein liquid diet supplementation as much as 2 bottles (200 mL) per day for 7-10 days. Furthermore, the nutritional status of the patient was assessed.Results: By administering high-protein liquid diet supplementation, there was a tendency to increase the strength of the right handgrip in 3 subjects (50%), the tendency to increase body mass index (BMI) in 3 subjects (50%), Subjective Global Assessment (SGA) score improved in 2 subjects with mild/moderate malnutrition (33.3%) and 1 subject with normal nutrition (16.7%), and the tendency to increase the fat-free mass in 3 subjects (50%).Conclusion: The administration of high protein liquid dietary supplementation tended to increase the strength of the right handgrip, BMI, SGA score, and body fat-free mass index.
背景:营养不良是住院患者中一个非常普遍的问题。根据在各国进行的研究,医院营养不良的发生率在20-45%之间。医院营养不良可能是由于营养摄入不足、胃肠道营养吸收受损、疾病导致的营养流失或疾病期间代谢需求增加造成的。营养是愈合过程的基础,因为它需要通过各种酶反应获得良好的营养。一些研究表明,医院营养不良会增加发病率和死亡率,延长住院时间,并延迟康复。为了改善营养状况,可以给予高蛋白饮食。流质饮食是另一种营养形式,因为它更容易吞咽。方法:本研究采用双盲随机对照试验,评估高蛋白液体膳食补充剂对营养不良住院患者的疗效。根据ESPEN 2015标准评估患者的营养状况。将出现营养不良的患者分为两组,对照组给予正常蛋白流质饮食,干预组给予高蛋白流质饮食补充,每天2瓶(200 mL),持续7-10天。此外,还评估了患者的营养状况。结果:补充高蛋白液体饮食后,3例(50%)受试者的右手握力有增加的趋势,3例(50%)受试者的体重指数(BMI)有增加的趋势,2例(33.3%)轻度/中度营养不良者和1例(16.7%)营养正常者的主观整体评估(SGA)评分有改善的趋势,3例(50%)受试者的无脂质量有增加的趋势。结论:高蛋白液体膳食补充剂倾向于增加右手握力、BMI、SGA评分和体脂质量指数。
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引用次数: 0
COVID-19 in A Liver Cirrhosis Patient 一名肝硬化患者的COVID-19
Lia Sasmithae
The COVID-19 pandemic is a novel disease and posed a great challenge in the current healthcare system. The exact impact of the COVID-19 virus on the liver is still unknown. However, in a patient with chronic liver disease, most COVID-19 infections will affect the survival rate and initiate liver decompensation. This study reported a 50-years-old man who complained about bloody vomit and black tarry stool with COVID-19 infection. Physical examination findings included hematemesis, pale conjunctiva, ascites, collateral vein; and from the rectal toucher, there was melena. There was no fever, cough, or shortness of breath. The laboratory and radiological examinations showed that there were normochromic normocytic anemia, hypoalbuminemia, slightly increased ALT/AST, HBsAg (+), and abdominal ultrasound findings were liver cirrhosis with ascites. The patient was screened for the COVID-19 antigen swab test (+), further confirmed by the COVID-19 PCR swab test (+). The treatment given for hematemesis and melena was Gastric Cooling; the patient was fasted, then received somatostatin PPI drip, Vitamin K injection, PRC transfusion, lactulose, ceftriaxone, ascites fluid puncture, and albumin transfusion. After the bleeding resolved, the patient received spironolactone and propranolol. The treatments for COVID-19 were Azithromycin, Favivirapir, Vitamin D, Vitamin K, and Zinc. The patient was hospitalized for 11 days and then improved. Conclusion: This study reported a case of a 50 years-old man with ruptured esophageal varices due to liver cirrhosis with concomitant COVID-19 infection and improved with comprehensive therapy despite the limited facilities at the hospital.
2019冠状病毒病大流行是一种新型疾病,对当前的医疗卫生体系提出了巨大挑战。COVID-19病毒对肝脏的确切影响尚不清楚。然而,在慢性肝病患者中,大多数COVID-19感染会影响生存率并引发肝脏失代偿。本研究报告了一名50岁的男性,他抱怨呕吐血和黑焦油便感染了COVID-19。体格检查发现:呕血、结膜苍白、腹水、侧静脉;从直肠触碰器上,发现了黑肠。没有发烧、咳嗽或呼吸急促。实验室及影像学检查示:常染性常胞性贫血,低白蛋白血症,ALT/AST、HBsAg(+)轻度升高,腹部超声示肝硬化伴腹水。筛查患者进行COVID-19抗原拭子试验(+),并进一步进行COVID-19 PCR拭子试验(+)。吐血黑黑的治疗方法为胃凉;禁食后滴注生长抑素PPI、注射维生素K、输注PRC、乳果糖、头孢曲松、腹水穿刺、白蛋白输注。出血消退后,给予螺内酯和心得安。COVID-19的治疗方法是阿奇霉素、Favivirapir、维生素D、维生素K和锌。患者住院11天后病情好转。结论:本研究报告了一例50岁男性肝硬化食管静脉曲张破裂并合并COVID-19感染的病例,尽管医院设施有限,但经综合治疗病情好转。
{"title":"COVID-19 in A Liver Cirrhosis Patient","authors":"Lia Sasmithae","doi":"10.24871/231202287-91","DOIUrl":"https://doi.org/10.24871/231202287-91","url":null,"abstract":"The COVID-19 pandemic is a novel disease and posed a great challenge in the current healthcare system. The exact impact of the COVID-19 virus on the liver is still unknown. However, in a patient with chronic liver disease, most COVID-19 infections will affect the survival rate and initiate liver decompensation. This study reported a 50-years-old man who complained about bloody vomit and black tarry stool with COVID-19 infection. Physical examination findings included hematemesis, pale conjunctiva, ascites, collateral vein; and from the rectal toucher, there was melena. There was no fever, cough, or shortness of breath. The laboratory and radiological examinations showed that there were normochromic normocytic anemia, hypoalbuminemia, slightly increased ALT/AST, HBsAg (+), and abdominal ultrasound findings were liver cirrhosis with ascites. The patient was screened for the COVID-19 antigen swab test (+), further confirmed by the COVID-19 PCR swab test (+). The treatment given for hematemesis and melena was Gastric Cooling; the patient was fasted, then received somatostatin PPI drip, Vitamin K injection, PRC transfusion, lactulose, ceftriaxone, ascites fluid puncture, and albumin transfusion. After the bleeding resolved, the patient received spironolactone and propranolol. The treatments for COVID-19 were Azithromycin, Favivirapir, Vitamin D, Vitamin K, and Zinc. The patient was hospitalized for 11 days and then improved. Conclusion: This study reported a case of a 50 years-old man with ruptured esophageal varices due to liver cirrhosis with concomitant COVID-19 infection and improved with comprehensive therapy despite the limited facilities at the hospital.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"38 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88951749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The prevalence and habit-associated risk factors of gastroesophageal reflux disease among fishermen in Indonesia 印尼渔民胃食管反流病患病率及习惯相关危险因素
Pub Date : 2022-01-05 DOI: 10.24871/2232021174-179
A. Zein, Catur Setiya Sulistiyana, T. Permatasari, U. Khasanah, T. Pratamawati, Ismayanti Ismayanti, Dwi Listiany Corneli, Eni Suhaeni
Background. This study was aimed to investigate the prevalence and habit-associated risk factors of gastroesophageal reflux disease (GERD) among fishermen.Methods. A cross-sectional study was conducted among 168 adult fishermen in Cirebon Regency, West Java, Indonesia. A self-administered questionnaire was given. The questionnaire consisted of demographic characteristics and validated GERD questionnaire (GERDQ) in Indonesian language. Data were analyzed using descriptive statistics and chi-square test. The study has been approved by the Medical Research Ethic Comiittee.Results. The medan age of the participants was 39.0 (24-86) years old. They were predominanty (60.7%) female. The prevalence of GERD was 22.6%. According to bivariate analysis, there was association between smoking (PR 1.181; 95%CI 1.013-1.377;p 0.041), high-salt intake (PR 2.419;95%CI 1.079-5.424; p 0.029), herb consumption (PR 3.068; 95%CI 1.307-7.200; p 0.008), poor hand hygiene (PR 3.202; 95%ci 1.445-7.095; p 0.003), and non-steroidal anti-inflammatory drug (NSAID) consumption (PR 3.062; 95%CI 1.446-6.488; p 0.00) with GERD. Tea consumption, coffee consumption, and raw vegetable eating were not associated with GERD.Conclusions This population-based study showed that the prevalence of GERD among fishermen in Indonesia is high. Habits associated with GERD in this study were smoking, high-salt intake, herb consumption poor, hand hygiene,
背景。本研究旨在调查渔民胃食管反流病(GERD)的患病率及与习惯相关的危险因素。在印度尼西亚西爪哇的Cirebon Regency对168名成年渔民进行了横断面研究。给出了一份自我管理的问卷。问卷由人口学特征和印尼语GERDQ组成。资料分析采用描述性统计和卡方检验。该研究已获得医学研究伦理委员会的批准。参与者的平均年龄为39.0岁(24-86岁)。以女性居多(60.7%)。胃反流发生率为22.6%。根据双变量分析,吸烟与肺癌之间存在相关性(PR为1.181;95%CI 1.013-1.377;p 0.041),高盐摄入(PR 2.419;95%CI 1.079-5.424;p 0.029),草药消费(PR 3.068;95%可信区间1.307 - -7.200;p 0.008),手卫生差(PR 3.202;95%可信区间1.445 - -7.095;p 0.003),非甾体抗炎药(NSAID)的使用(PR 3.062;95%可信区间1.446 - -6.488;p 0.00)。喝茶、喝咖啡和吃生蔬菜与胃反流没有关系。结论:这项基于人群的研究表明,印度尼西亚渔民中GERD的患病率很高。在这项研究中,与胃反流相关的习惯包括吸烟、高盐摄入、草药摄入不足、手卫生、
{"title":"The prevalence and habit-associated risk factors of gastroesophageal reflux disease among fishermen in Indonesia","authors":"A. Zein, Catur Setiya Sulistiyana, T. Permatasari, U. Khasanah, T. Pratamawati, Ismayanti Ismayanti, Dwi Listiany Corneli, Eni Suhaeni","doi":"10.24871/2232021174-179","DOIUrl":"https://doi.org/10.24871/2232021174-179","url":null,"abstract":"Background. This study was aimed to investigate the prevalence and habit-associated risk factors of gastroesophageal reflux disease (GERD) among fishermen.Methods. A cross-sectional study was conducted among 168 adult fishermen in Cirebon Regency, West Java, Indonesia. A self-administered questionnaire was given. The questionnaire consisted of demographic characteristics and validated GERD questionnaire (GERDQ) in Indonesian language. Data were analyzed using descriptive statistics and chi-square test. The study has been approved by the Medical Research Ethic Comiittee.Results. The medan age of the participants was 39.0 (24-86) years old. They were predominanty (60.7%) female. The prevalence of GERD was 22.6%. According to bivariate analysis, there was association between smoking (PR 1.181; 95%CI 1.013-1.377;p 0.041), high-salt intake (PR 2.419;95%CI 1.079-5.424; p 0.029), herb consumption (PR 3.068; 95%CI 1.307-7.200; p 0.008), poor hand hygiene (PR 3.202; 95%ci 1.445-7.095; p 0.003), and non-steroidal anti-inflammatory drug (NSAID) consumption (PR 3.062; 95%CI 1.446-6.488; p 0.00) with GERD. Tea consumption, coffee consumption, and raw vegetable eating were not associated with GERD.Conclusions This population-based study showed that the prevalence of GERD among fishermen in Indonesia is high. Habits associated with GERD in this study were smoking, high-salt intake, herb consumption poor, hand hygiene,","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"478 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"76369349","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Pancreatic Tuberculosis: Current Update on Clinical Manifestation and Diagnostic Modalities 胰腺结核:临床表现和诊断方式的最新进展
Pub Date : 2022-01-05 DOI: 10.24871/2232021217-225
Samudra Andi Yusuf, H. Maulahela, Anjar Raraswati, Maureen Irawati Koesnadi
Pancreatic tuberculosis is a very rare disease in either immunocompetent or immunocompromised hosts.The incidence of pancreatic tuberculosis was reported to be less than 4.7% in an autopsy series on tuberculosis patients in 1944 and 2% in another autopsy series in 1966.Despite that, in recent times, an increase in the number of reports of pancreatic TB has been noted.This condition is possibly caused by an improvement in diagnostic imaging tools, the development of different techniques that make obtaining specimens from the pancreas possible, and an increase in HIV prevalence worldwide. Therefore, this review article discusses the current update in the clinical manifestations and diagnostic modalities of pancreatic tuberculosis.Pancreatic tuberculosis is a very rare condition with a various range of non-specific clinical presentation and image features overlapping with those seen in pancreatic neoplasia. A combination of diagnostic modalities should be done to establish a diagnosis of pancreatic tuberculosis. Currently, direct histopathological examination is the best way of diagnosing tuberculosis. US/CT/EUS-guided biopsy is the recommended diagnostic technique. Most patients with pancreatic tuberculosis respond well to anti-tuberculosis drugs. 
胰腺结核在免疫正常或免疫功能低下的宿主中是一种非常罕见的疾病。据报道,在1944年对结核病患者的尸检系列中,胰腺结核的发病率低于4.7%,在1966年的另一尸检系列中为2%。尽管如此,近年来,胰腺结核的报告数量有所增加。这种情况可能是由于诊断成像工具的改进,不同技术的发展使得从胰腺获取标本成为可能,以及全球艾滋病毒流行率的增加。因此,本文就胰腺结核的临床表现和诊断方法的最新进展进行综述。胰腺结核是一种非常罕见的疾病,其各种非特异性临床表现和图像特征与胰腺肿瘤重叠。应结合多种诊断方式来确定胰腺癌的诊断。目前,直接组织病理学检查是诊断结核病的最佳方法。US/CT/ eus引导活检是推荐的诊断技术。大多数胰腺结核患者对抗结核药物反应良好。
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引用次数: 0
Primary Tupaia Javanica Hepatocyte Culture as an In Vitro Model for Human Hepatitis B Virus Infection 原代土鳖肝细胞培养作为人乙型肝炎病毒感染的体外模型
Pub Date : 2022-01-05 DOI: 10.24871/2232021203-209
K. Kalista, M. Surya, S. Mariya, D. Iskandriati, I. Hasan, R. Gani
Background: Hepatitis B virus (HBV) infection is still one of the biggest health problems in the world, which could lead to chronic hepatitis, cirrhosis and hepatocellular carcinoma. Treatment for HBV infection has not yet achieved a functional cure. More studies are needed to investigate human HBV (HuHBV), but the scarcity of animal models for HuHBV infection became a barrier. Recently, many studies have shown that Tupaia are suitable for the study of HuHBV. The purpose of this study was to develop a primary tupaia hepatocyte (PTH) culture from T. javanica, a species of Tupaia found in Indonesia, and to prove that HuHBV can replicate in the PTH.Method: In vitro experimental study using PTH isolated from five wild adult T. javanica in Primate Research Center, IPB University. HuHBV was taken from humans with HBsAg and HBV-DNA (+). PTH cells then were infected with HuHBV after reaching 80% confluence. Observation on PTH cells was done everyday for 20 days. Qualitative and quantitative HBsAg were measured using a CMIA while HBV-DNA and cccDNA were measured by RT-PCR.Results: A cytopathic effect was seen on day post infection (DPI)-16. HBsAg and HBV-DNA were detected from DPI-2 until DPI-18, with HBV-DNA level peaked on DPI-12. cccDNA concentration was fluctuating from DPI-2 until DPI-20 with highest level on DPI-16.Conclusion: HuHBV could infect and replicate in PTH from T. javanica can be infected with HuHBV and HuHBV can replicate in the PTH from T. javanica.
背景:乙型肝炎病毒(HBV)感染仍然是世界上最大的健康问题之一,可导致慢性肝炎、肝硬化和肝细胞癌。HBV感染的治疗尚未实现功能性治愈。人类乙型肝炎病毒(HuHBV)的研究需要更多的研究,但缺乏HuHBV感染的动物模型成为一个障碍。近年来,许多研究表明,Tupaia适合HuHBV的研究。本研究的目的是从印度尼西亚的一种图帕亚植物T. javanica中培养原代图帕亚肝细胞(PTH),并证明HuHBV可以在PTH中复制。方法:利用IPB大学灵长类动物研究中心5只野生成年爪哇家兔的PTH进行体外实验研究。HuHBV取自携带HBsAg和HBV-DNA(+)的人。融合度达到80%后,用HuHBV感染PTH细胞。每天观察PTH细胞,连续观察20 d。采用CMIA法测定HBsAg的定性和定量,RT-PCR法测定HBV-DNA和cccDNA。结果:感染后第1天(DPI -16)出现细胞病变。从DPI-2至DPI-18检测HBsAg和HBV-DNA,在DPI-12时HBV-DNA水平最高。cccDNA浓度从DPI-2到DPI-20不等,其中DPI-16的cccDNA浓度最高。结论:HuHBV可感染爪哇假体PTH并在PTH中复制,HuHBV可感染爪哇假体PTH, HuHBV可在PTH中复制。
{"title":"Primary Tupaia Javanica Hepatocyte Culture as an In Vitro Model for Human Hepatitis B Virus Infection","authors":"K. Kalista, M. Surya, S. Mariya, D. Iskandriati, I. Hasan, R. Gani","doi":"10.24871/2232021203-209","DOIUrl":"https://doi.org/10.24871/2232021203-209","url":null,"abstract":"Background: Hepatitis B virus (HBV) infection is still one of the biggest health problems in the world, which could lead to chronic hepatitis, cirrhosis and hepatocellular carcinoma. Treatment for HBV infection has not yet achieved a functional cure. More studies are needed to investigate human HBV (HuHBV), but the scarcity of animal models for HuHBV infection became a barrier. Recently, many studies have shown that Tupaia are suitable for the study of HuHBV. The purpose of this study was to develop a primary tupaia hepatocyte (PTH) culture from T. javanica, a species of Tupaia found in Indonesia, and to prove that HuHBV can replicate in the PTH.Method: In vitro experimental study using PTH isolated from five wild adult T. javanica in Primate Research Center, IPB University. HuHBV was taken from humans with HBsAg and HBV-DNA (+). PTH cells then were infected with HuHBV after reaching 80% confluence. Observation on PTH cells was done everyday for 20 days. Qualitative and quantitative HBsAg were measured using a CMIA while HBV-DNA and cccDNA were measured by RT-PCR.Results: A cytopathic effect was seen on day post infection (DPI)-16. HBsAg and HBV-DNA were detected from DPI-2 until DPI-18, with HBV-DNA level peaked on DPI-12. cccDNA concentration was fluctuating from DPI-2 until DPI-20 with highest level on DPI-16.Conclusion: HuHBV could infect and replicate in PTH from T. javanica can be infected with HuHBV and HuHBV can replicate in the PTH from T. javanica.","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"71 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91235504","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enterochromaffin-like (ECL) cells Hyperplasia in Fundic Gland Polyp and Its Association with the Usage of Proton Pump Inhibitors 基底腺息肉肠色素样细胞(ECL)增生及其与质子泵抑制剂使用的关系
Pub Date : 2022-01-05 DOI: 10.24871/2232021188-195
E. Krisnuhoni, Fili Sufangga, D. Handjari, N. Rahadiani, Marini Stephanie
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-
{"title":"Enterochromaffin-like (ECL) cells Hyperplasia in Fundic Gland Polyp and Its Association with the Usage of Proton Pump Inhibitors","authors":"E. Krisnuhoni, Fili Sufangga, D. Handjari, N. Rahadiani, Marini Stephanie","doi":"10.24871/2232021188-195","DOIUrl":"https://doi.org/10.24871/2232021188-195","url":null,"abstract":"<jats:p>-</jats:p>","PeriodicalId":22564,"journal":{"name":"The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy","volume":"32 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2022-01-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"90163362","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
The Indonesian Journal of Gastroenterology, Hepatology and Digestive Endoscopy
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