Pub Date : 2014-10-30DOI: 10.4161/2167549X.2014.968483
Y. Molkov, D. Zaretsky
Fatal hyperthermia after administration of various amphetamines is well-known clinical phenomenon, however, there is no consistent theory explaining its etiology and/or pathogenesis. Dose-dependence of temperature responses to methamphetamine is intricate. Recently, using mathematical modeling it was suggested that delicate interplay of excitatory and inhibitory mechanisms underlies this complexity.
{"title":"Balanced excitation and inhibition in temperature responses to meth","authors":"Y. Molkov, D. Zaretsky","doi":"10.4161/2167549X.2014.968483","DOIUrl":"https://doi.org/10.4161/2167549X.2014.968483","url":null,"abstract":"Fatal hyperthermia after administration of various amphetamines is well-known clinical phenomenon, however, there is no consistent theory explaining its etiology and/or pathogenesis. Dose-dependence of temperature responses to methamphetamine is intricate. Recently, using mathematical modeling it was suggested that delicate interplay of excitatory and inhibitory mechanisms underlies this complexity.","PeriodicalId":22565,"journal":{"name":"Temperature: Multidisciplinary Biomedical Journal","volume":"98 1","pages":"154 - 156"},"PeriodicalIF":0.0,"publicationDate":"2014-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80624531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2014-10-30DOI: 10.4161/23328940.2014.969074
E. Kiyatkin
Hyperthermia is a known effect induced by psychomotor stimulants and pathological hyperthermia is a prominent symptom of acute intoxication with these drugs in humans. In this manuscript, I will review our recent work concerning the brain hyperthermic effects of several known and recently appeared psychostimulant drugs of abuse (cocaine, methamphetamine, MDMA, methylone, and MDPV). Specifically, I will consider the role of activity state and environmental conditions in modulating the brain temperature effects of these drugs and their acute toxicity. Although some of these drugs are structurally similar and interact with the same brain substrates, there are important differences in their temperature effects in quiet resting conditions and the type of modulation of these temperature effects under conditions that mimic basic aspects of human drug use (social interaction, moderately warm environments). These data could be important for understanding the potential dangers of each drug and ultimately preventing adverse health complications associated with acute drug-induced intoxication.
{"title":"State-dependent and environmental modulation of brain hyperthermic effects of psychoactive drugs of abuse","authors":"E. Kiyatkin","doi":"10.4161/23328940.2014.969074","DOIUrl":"https://doi.org/10.4161/23328940.2014.969074","url":null,"abstract":"Hyperthermia is a known effect induced by psychomotor stimulants and pathological hyperthermia is a prominent symptom of acute intoxication with these drugs in humans. In this manuscript, I will review our recent work concerning the brain hyperthermic effects of several known and recently appeared psychostimulant drugs of abuse (cocaine, methamphetamine, MDMA, methylone, and MDPV). Specifically, I will consider the role of activity state and environmental conditions in modulating the brain temperature effects of these drugs and their acute toxicity. Although some of these drugs are structurally similar and interact with the same brain substrates, there are important differences in their temperature effects in quiet resting conditions and the type of modulation of these temperature effects under conditions that mimic basic aspects of human drug use (social interaction, moderately warm environments). These data could be important for understanding the potential dangers of each drug and ultimately preventing adverse health complications associated with acute drug-induced intoxication.","PeriodicalId":22565,"journal":{"name":"Temperature: Multidisciplinary Biomedical Journal","volume":"27 1","pages":"201 - 213"},"PeriodicalIF":0.0,"publicationDate":"2014-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"77231482","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Szilárd Donhoffer (1902–1999)","authors":"Z. Szelényi, M. Székely","doi":"10.4161/TEMP.29516","DOIUrl":"https://doi.org/10.4161/TEMP.29516","url":null,"abstract":"The authors summarize the main events in the long life of Szilárd Donhoffer and his importance in founding thermoregulatory research at Pécs, Hungary.","PeriodicalId":22565,"journal":{"name":"Temperature: Multidisciplinary Biomedical Journal","volume":"132 1","pages":"76 - 79"},"PeriodicalIF":0.0,"publicationDate":"2014-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88850251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
The past 60 years have witnessed remarkable advances in our understanding of the mechanisms that control body temperature, but except for brief historical background chapters occasionally included in didactic monographs and symposia proceedings, no book, to my best knowledge, has yet been published on the “makers” of thermal physiology. Thermal physiology is an integrative science, and this is what makes the field so fascinating and its history so engrossing. Indeed, when I entered the field as a graduate student in 1954, it was a popular area of research among scientists of all stripes cardiovascular, respiratory, musculo-skeletal, nervous, endocrine and other physiologists as well as biochemists, biophysicists, and psychologists all contributing their expertise toward elucidating the role of their particular specialty in controlling body temperature. Their interest was, in part, a continuation of their then still recent wartime experiences when many had served in military laboratories studying the effects of harsh environments on soldiers’ performance. I had the privilege of knowing personally most of the principal players both in the USA and abroad—many sadly now gone—over my 60 years in the field and I recall reasonably well the various steps of our journey of discovery. Right now seemed to me, therefore, an opportune time to recapitulate the history of thermal physiology for the benefit of those among the current generation of workers in all disciplines now involved in our field as well as of others who may be interested in learning about the research that has led to our current knowledge of how the body maintains its temperature. I felt reasonably safe that I could recount with adequate authority and authenticity the American contribution to this history. But my contemporaries in the UK, Germany, Japan, etc. have naturally had closer and more continuous relationships with their own compatriots and, therefore, can reflect on them with greater authority than I. Those that I approached have graciously agreed to be contributors to this history. This book is not meant to be a definitive, exhaustive treatise of the worldwide history of temperature regulation research since its beginning, but rather a personal recounting of, in particular, the people who contributed to its development, told from the memory and subjective perspective of witnesses to it who, moreover, were themselves major participants. That is to say, this book will present the global history of thermal physiology not as a dry recompilation of already well known, published facts, but rather as a lively account from the personal, almost autobiographical viewpoint of the invited contributors, so that not only the important contributions of the scientists that will be recalled may be highlighted, but also so that some insight into their persona and how they thought and worked may be gained. Several of the chapters are already in; they are written in the unique style and from the perso
{"title":"A first-hand account by the international participants of the past 75 years’ advancements in thermophysiology is forthcoming","authors":"C. Blatteis","doi":"10.4161/TEMP.29598","DOIUrl":"https://doi.org/10.4161/TEMP.29598","url":null,"abstract":"The past 60 years have witnessed remarkable advances in our understanding of the mechanisms that control body temperature, but except for brief historical background chapters occasionally included in didactic monographs and symposia proceedings, no book, to my best knowledge, has yet been published on the “makers” of thermal physiology. Thermal physiology is an integrative science, and this is what makes the field so fascinating and its history so engrossing. Indeed, when I entered the field as a graduate student in 1954, it was a popular area of research among scientists of all stripes cardiovascular, respiratory, musculo-skeletal, nervous, endocrine and other physiologists as well as biochemists, biophysicists, and psychologists all contributing their expertise toward elucidating the role of their particular specialty in controlling body temperature. Their interest was, in part, a continuation of their then still recent wartime experiences when many had served in military laboratories studying the effects of harsh environments on soldiers’ performance. I had the privilege of knowing personally most of the principal players both in the USA and abroad—many sadly now gone—over my 60 years in the field and I recall reasonably well the various steps of our journey of discovery. Right now seemed to me, therefore, an opportune time to recapitulate the history of thermal physiology for the benefit of those among the current generation of workers in all disciplines now involved in our field as well as of others who may be interested in learning about the research that has led to our current knowledge of how the body maintains its temperature. I felt reasonably safe that I could recount with adequate authority and authenticity the American contribution to this history. But my contemporaries in the UK, Germany, Japan, etc. have naturally had closer and more continuous relationships with their own compatriots and, therefore, can reflect on them with greater authority than I. Those that I approached have graciously agreed to be contributors to this history. This book is not meant to be a definitive, exhaustive treatise of the worldwide history of temperature regulation research since its beginning, but rather a personal recounting of, in particular, the people who contributed to its development, told from the memory and subjective perspective of witnesses to it who, moreover, were themselves major participants. That is to say, this book will present the global history of thermal physiology not as a dry recompilation of already well known, published facts, but rather as a lively account from the personal, almost autobiographical viewpoint of the invited contributors, so that not only the important contributions of the scientists that will be recalled may be highlighted, but also so that some insight into their persona and how they thought and worked may be gained. Several of the chapters are already in; they are written in the unique style and from the perso","PeriodicalId":22565,"journal":{"name":"Temperature: Multidisciplinary Biomedical Journal","volume":"64 1","pages":"30 - 31"},"PeriodicalIF":0.0,"publicationDate":"2014-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85183238","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carl Vincent Gisolfi (1942–2008) was a Distinguished Professor of Exercise Science at the University of Iowa whose contributions included mentoring future investigators and seminal studies in the areas of thermoregulation during exercise, responses of the diencephalon to elevated temperatures, fluid absorption during heat stress, and the role of heat shock proteins in circulatory failure.
{"title":"The legacy of Carl Vincent Gisolfi in temperature regulation","authors":"C. Tipton, K. Kregel","doi":"10.4161/temp.29005","DOIUrl":"https://doi.org/10.4161/temp.29005","url":null,"abstract":"Carl Vincent Gisolfi (1942–2008) was a Distinguished Professor of Exercise Science at the University of Iowa whose contributions included mentoring future investigators and seminal studies in the areas of thermoregulation during exercise, responses of the diencephalon to elevated temperatures, fluid absorption during heat stress, and the role of heat shock proteins in circulatory failure.","PeriodicalId":22565,"journal":{"name":"Temperature: Multidisciplinary Biomedical Journal","volume":"2 1","pages":"6 - 11"},"PeriodicalIF":0.0,"publicationDate":"2014-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80551202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
This editorial marks the starting point for a new journal, Temperature. This latest addition to the Landes Bioscience collection of research journals will be a multidisciplinary publication focused on the interactions between living matter and temperature. The first question, however, that the reader is likely to have is not about the journal’s thematic boundaries. The first question is likely to be: “Why do we need another journal?” The News section of Science recently published a report about a bogus “research article,” which was intentionally packed with deep flaws and then submitted to many new open-access journals; 150 of them rapidly accepted this “piece of wisdom.” At first, you may be surprised that so many journals are willing to publish junk, but your surprise will fade away rather quickly when you recollect how many e-mail messages you deleted today that contained an invitation to publish in a new online journal founded by some fairytale magician in a beautiful land far, far away. Don’t we already have many (perhaps too many) high-quality, well-established research journals run by authoritative academic societies and published by reputable companies? Surely, they can satisfy any publishing need imaginable for every scientist who dares to write something! And so I thought too—initially. But as I thought more, I realized that not all my publishing needs, however modest they may be, are readily met by the good old journals. This editorial will address one feature that is missing from nearly all large journals, at least for people interested in temperature.
{"title":"New research journals are needed and can compete with titans","authors":"A. A. Romanovsky","doi":"10.4161/TEMP.27666","DOIUrl":"https://doi.org/10.4161/TEMP.27666","url":null,"abstract":"This editorial marks the starting point for a new journal, Temperature. This latest addition to the Landes Bioscience collection of research journals will be a multidisciplinary publication focused on the interactions between living matter and temperature. The first question, however, that the reader is likely to have is not about the journal’s thematic boundaries. The first question is likely to be: “Why do we need another journal?” The News section of Science recently published a report about a bogus “research article,” which was intentionally packed with deep flaws and then submitted to many new open-access journals; 150 of them rapidly accepted this “piece of wisdom.” At first, you may be surprised that so many journals are willing to publish junk, but your surprise will fade away rather quickly when you recollect how many e-mail messages you deleted today that contained an invitation to publish in a new online journal founded by some fairytale magician in a beautiful land far, far away. Don’t we already have many (perhaps too many) high-quality, well-established research journals run by authoritative academic societies and published by reputable companies? Surely, they can satisfy any publishing need imaginable for every scientist who dares to write something! And so I thought too—initially. But as I thought more, I realized that not all my publishing needs, however modest they may be, are readily met by the good old journals. This editorial will address one feature that is missing from nearly all large journals, at least for people interested in temperature.","PeriodicalId":22565,"journal":{"name":"Temperature: Multidisciplinary Biomedical Journal","volume":"41 1","pages":"1 - 5"},"PeriodicalIF":0.0,"publicationDate":"2013-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"88246402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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