Hajime Yoshimasa, J. Ike, Y. Sakuno, Kyoji Yoshida
: A 7-years-old, mix breed, male dog was referred to our hospital with intractable dermatitis. About one year earlier, this dog had been referred to a veterinarian who had been treating it for dermatitis around the prepuce. Initially, we diagnosed with iatrogenic Cushing disease with steroid dermatopathy and modified the treatment. After tapering oral prednisolone and discontinuing the topical steroid, the dog recovered in 5 months. After a further 1 month, a nodular lesion was observed around the preputial orifice. A biopsy was performed and, a histopathological diagnosis of epitheliotropic T-cell lymphoma was made. Complete remission has been sustained for approximately 10 months following resection.
{"title":"Cutaneous epitheliotropic T-cell lymphoma in a dog observed during treatment for iatrogenic Cushing disease which was removed by surgical resection","authors":"Hajime Yoshimasa, J. Ike, Y. Sakuno, Kyoji Yoshida","doi":"10.2736/JJVD.27.21","DOIUrl":"https://doi.org/10.2736/JJVD.27.21","url":null,"abstract":": A 7-years-old, mix breed, male dog was referred to our hospital with intractable dermatitis. About one year earlier, this dog had been referred to a veterinarian who had been treating it for dermatitis around the prepuce. Initially, we diagnosed with iatrogenic Cushing disease with steroid dermatopathy and modified the treatment. After tapering oral prednisolone and discontinuing the topical steroid, the dog recovered in 5 months. After a further 1 month, a nodular lesion was observed around the preputial orifice. A biopsy was performed and, a histopathological diagnosis of epitheliotropic T-cell lymphoma was made. Complete remission has been sustained for approximately 10 months following resection.","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"59 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91024389","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Chiaki Kitanaka, R. Asahina, Yuta Yamamoto, K. Mitsuhashi, Mami Hiasa, Chihiro Kayama, Natsuki Kamo, Maiko Ogawa, N. Takemura, M. Nagata
{"title":"A case of cat with traumatic alopecia that died due to severe pulmonary edema after administration of triamcinolone","authors":"Chiaki Kitanaka, R. Asahina, Yuta Yamamoto, K. Mitsuhashi, Mami Hiasa, Chihiro Kayama, Natsuki Kamo, Maiko Ogawa, N. Takemura, M. Nagata","doi":"10.2736/jjvd.26.205","DOIUrl":"https://doi.org/10.2736/jjvd.26.205","url":null,"abstract":"","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"14 1","pages":"205-207"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74759596","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
We report a case of subcorneal pustular dermatosis in a dog with characteristic clinical symptoms and histopathological findings. Papule and pustule formations were observed throughout the body. Aseptic pustular dermatosis was diagnosed based on bacterial culture tests. A histopathological examination revealed subcorneal pustule formation. The dog had flea bites and heat stroke before the development of pustules; furthermore, no pustules were found during or immediately after administering the treatment specific to these conditions. This confirms that the lesions we observed were in the early stages of their development. Previous case reports have indicated that the early stages of this condition are not necessarily accompanied by itching. The patient’s condition improved rapidly after treatment with dapsone.
{"title":"A case of suspected subcorneal pustular dermatosis in a French bulldog","authors":"T. Sakakibara","doi":"10.2736/jjvd.26.79","DOIUrl":"https://doi.org/10.2736/jjvd.26.79","url":null,"abstract":"We report a case of subcorneal pustular dermatosis in a dog with characteristic clinical symptoms and histopathological findings. Papule and pustule formations were observed throughout the body. Aseptic pustular dermatosis was diagnosed based on bacterial culture tests. A histopathological examination revealed subcorneal pustule formation. The dog had flea bites and heat stroke before the development of pustules; furthermore, no pustules were found during or immediately after administering the treatment specific to these conditions. This confirms that the lesions we observed were in the early stages of their development. Previous case reports have indicated that the early stages of this condition are not necessarily accompanied by itching. The patient’s condition improved rapidly after treatment with dapsone.","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"73 1","pages":"79-82"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83353040","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
K. Sadamoto, Yuichiro Sakamoto, M. Kadoya, Toshihide Suenobu
: A post-marketing surveillance study was conducted to assess the safety and efficacy of LOMEWON ® , 0.3% lomefloxacin otic solution, for bacterial otitis externa in dogs. In this study, we performed a safety study to investigate the incidence of adverse drug reactions to LOMEWON ® . We also performed an efficacy study to investigate its efficacy, and to compare its bacteriological efficacy with that of the clinical trial results. Among 613 cases, 3 adverse drug reactions were reported: vomiting, ear abrasion, and external auditory canal lesion. The incidence rate of adverse drug reactions was 0.49%. The efficacy rate of 103 cases in the efficacy study was 66.0%. Furthermore, the disappearance rates of S. intermedius , S. canis , and P. aeruginoca were 77.1%, 79.0%, and 92.3%, respectively, showing that LOMEWON ® had high efficacy in eradicating these bacterial species. These results indicate that LOMEWON ® is a useful drug with a low incidence rate of adverse drug reactions.
{"title":"Post-Marketing Surveillance of Lomefloxacin (LOMEWON®) in dogs with bacterial otitis externa","authors":"K. Sadamoto, Yuichiro Sakamoto, M. Kadoya, Toshihide Suenobu","doi":"10.2736/jjvd.27.11","DOIUrl":"https://doi.org/10.2736/jjvd.27.11","url":null,"abstract":": A post-marketing surveillance study was conducted to assess the safety and efficacy of LOMEWON ® , 0.3% lomefloxacin otic solution, for bacterial otitis externa in dogs. In this study, we performed a safety study to investigate the incidence of adverse drug reactions to LOMEWON ® . We also performed an efficacy study to investigate its efficacy, and to compare its bacteriological efficacy with that of the clinical trial results. Among 613 cases, 3 adverse drug reactions were reported: vomiting, ear abrasion, and external auditory canal lesion. The incidence rate of adverse drug reactions was 0.49%. The efficacy rate of 103 cases in the efficacy study was 66.0%. Furthermore, the disappearance rates of S. intermedius , S. canis , and P. aeruginoca were 77.1%, 79.0%, and 92.3%, respectively, showing that LOMEWON ® had high efficacy in eradicating these bacterial species. These results indicate that LOMEWON ® is a useful drug with a low incidence rate of adverse drug reactions.","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"183 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"80427199","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Miho Terashima, T. Hisano, T. Fukamachi, Ichiro Imanishi, Mariko Ezumi, K. Iyori
: This study investigated the sparing effect on oclacitinib of several types of ceramide products in dogs with atopic dermatitis (AD). A total of 16 dogs with AD were enrolled. All dogs were treated with systemic oclacitinib (0.4–0.6 mg/kg, orally once daily) for at least three months. The dogs were randomly divided into two groups and treated with either a combination of oral and topical spray of ceramide products or topical spot-on ceramide products for 84 days. Oclacitinib was continuously administered in all cases at addition, there were no intergroup differences in each score at each endpoint (P>0.05). These results suggest that a combination of oral and topical ceramide products or a spot-on ceramide product may be useful for sparing oclacitinib therapy in dogs with AD.
{"title":"Pilot evaluation of the oclacitinib sparing effect of oral or topical ceramide products in the treatment of canine atopic dermatitis","authors":"Miho Terashima, T. Hisano, T. Fukamachi, Ichiro Imanishi, Mariko Ezumi, K. Iyori","doi":"10.2736/JJVD.27.15","DOIUrl":"https://doi.org/10.2736/JJVD.27.15","url":null,"abstract":": This study investigated the sparing effect on oclacitinib of several types of ceramide products in dogs with atopic dermatitis (AD). A total of 16 dogs with AD were enrolled. All dogs were treated with systemic oclacitinib (0.4–0.6 mg/kg, orally once daily) for at least three months. The dogs were randomly divided into two groups and treated with either a combination of oral and topical spray of ceramide products or topical spot-on ceramide products for 84 days. Oclacitinib was continuously administered in all cases at addition, there were no intergroup differences in each score at each endpoint (P>0.05). These results suggest that a combination of oral and topical ceramide products or a spot-on ceramide product may be useful for sparing oclacitinib therapy in dogs with AD.","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"257 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"82774431","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Y. Sawa, Godai Shumoto, T. Yokoyama, I. Mitsui, T. Kaneshima
An 8-year-old male neutered Scottish Fold, whose pruritic dermatitis treated with cyclosporine (CyA), showed chronic gastrointestinal symptoms Serum chemistry showed a decrease in the A/G ratio and an elevation in the anti-feline coronavirus (FCoV) antibody titer Based on the test results, FCoV infection due to immunodeficiency was suspected, therefore CyA was withdrawn As a replacement, oclacitinib was administered Pruritis was controlled by oclacitinib administration, and then improvement of gastrointestinal symptoms and decrease in the anti-FCoV antibody titer was also observed However, in a year and a half, the cat was diagnosed with kidney lymphoma, thus oclacitinib administration was withdrawn The result of this case suggest that oclacitinib administration could be an effective treatment of pruritic dermatitis in cats, but clinicians need to pay close attention to immunosuppression when using high dosages
{"title":"Use of oclacitinib for a cat with pruritic dermatitis suffering chronic diarrhea during treatment with cyclosporine","authors":"Y. Sawa, Godai Shumoto, T. Yokoyama, I. Mitsui, T. Kaneshima","doi":"10.2736/jjvd.26.15","DOIUrl":"https://doi.org/10.2736/jjvd.26.15","url":null,"abstract":"An 8-year-old male neutered Scottish Fold, whose pruritic dermatitis treated with cyclosporine (CyA), showed chronic gastrointestinal symptoms Serum chemistry showed a decrease in the A/G ratio and an elevation in the anti-feline coronavirus (FCoV) antibody titer Based on the test results, FCoV infection due to immunodeficiency was suspected, therefore CyA was withdrawn As a replacement, oclacitinib was administered Pruritis was controlled by oclacitinib administration, and then improvement of gastrointestinal symptoms and decrease in the anti-FCoV antibody titer was also observed However, in a year and a half, the cat was diagnosed with kidney lymphoma, thus oclacitinib administration was withdrawn The result of this case suggest that oclacitinib administration could be an effective treatment of pruritic dermatitis in cats, but clinicians need to pay close attention to immunosuppression when using high dosages","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"56 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"87472535","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
A 3 years and 3 months old, intact male domestic cat was presented with multiple papules and nodules as well as generalized sclerema. Histopathological analysis of the tissue samples obtained by skin biopsy and necropsy revealed an extensive and aggressive proliferation of spindle cells not only in sclerematous skin and the cutaneous nodules, but in skeletal muscle membranes and serosa. The findings in some cutaneous nodules were consistent with those of fibrosarcoma. Immunohistochemical analysis with antifeline leukemia virus revealed cytoplasmic staining of those proliferating spindle cells, suggesting that the histopathological changes were associated with feline leukemia virus or feline sarcoma virus.
{"title":"A feline case with multiple fibrosarcoma and systemic fibromatosis associated with feline leukemia virus/feline sarcoma virus","authors":"K. Hase, I. Hase, Y. Shimoyama, K. Nishifuji","doi":"10.2736/jjvd.26.75","DOIUrl":"https://doi.org/10.2736/jjvd.26.75","url":null,"abstract":"A 3 years and 3 months old, intact male domestic cat was presented with multiple papules and nodules as well as generalized sclerema. Histopathological analysis of the tissue samples obtained by skin biopsy and necropsy revealed an extensive and aggressive proliferation of spindle cells not only in sclerematous skin and the cutaneous nodules, but in skeletal muscle membranes and serosa. The findings in some cutaneous nodules were consistent with those of fibrosarcoma. Immunohistochemical analysis with antifeline leukemia virus revealed cytoplasmic staining of those proliferating spindle cells, suggesting that the histopathological changes were associated with feline leukemia virus or feline sarcoma virus.","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"23 1","pages":"75-78"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83959948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Successful management with fipronil spray in a cat with trombiculosis","authors":"Toru Shimazaki, M. Nagata","doi":"10.2736/jjvd.26.21","DOIUrl":"https://doi.org/10.2736/jjvd.26.21","url":null,"abstract":"","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"27 1","pages":"21-22"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"78737698","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Hemangiosarcoma of the lower eyelid in a cat and its postoperative medication","authors":"Yoshihiko Sato, Ryohei Sato","doi":"10.2736/jjvd.26.199","DOIUrl":"https://doi.org/10.2736/jjvd.26.199","url":null,"abstract":"","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"31 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74066216","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"A suspected adverse drug reaction caused by human-label cyclosporine in a dog with canine atopic dermatitis","authors":"Yukina Sugiyama, T. Kawai, Ryuji Araki, K. Ueda","doi":"10.2736/jjvd.26.147","DOIUrl":"https://doi.org/10.2736/jjvd.26.147","url":null,"abstract":"","PeriodicalId":22603,"journal":{"name":"The Japanese Journal of Veterinary Dermatology","volume":"414 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85578436","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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