F. Akter, S. H. Israfil, Mohammad Ali, A. Rouf, M. Alam, M. Rahman, G. Sultana
Aims: 'Poly C' stretch extending from 303 to 315 nucleotide positions known as (D310) by GeneBank within the non-coding region HVR-II of mitochondrial DNA (mtDNA) has been identified as a mutational hotspot of primary cancer. We aimed to find this mutation in Bangladeshi breast cancer patients and control samples for screening the changes in poly C stretches. Materials and Methods: We have analyzed a total of 98 breast cancer blood samples and 98 healthy control blood samples and extracted DNA from blood samples for direct sequencing using ABI®3130 Genetic Analyzer. Results: We observed 70.41% C insertion at 310 regions (P<0.001, OR = 16.30 and 95% CI=7.83-33.93) in breast cancer patient whereas it is present only in 12.24% healthy individuals. No alterations were observed in 29.59% breast cancer samples. We also check the mutation pattern at D315 regions, but no significant observation was found (P=1.00). Conclusions: This is the first study from Bangladeshi breast cancer (BC) patients indicating a relatively high frequency of D310 mutations, which suggests that mtDNA instability at D310 may be a common characteristic of BC, study also supports the hypothesis that mtDNA D310 screening may represent additional blood based biomarker for breast cancer prognosis.
目的:在线粒体DNA (mtDNA)的非编码区HVR-II中，从303到315个核苷酸位置的“Poly C”延伸(D310)已被GeneBank确定为原发性癌症的突变热点。我们的目的是在孟加拉国乳腺癌患者和对照样本中发现这种突变，以筛选聚C延伸的变化。材料和方法:我们共分析了98份乳腺癌血液样本和98份健康对照血液样本，并从血液样本中提取DNA，使用ABI®3130基因分析仪进行直接测序。结果:我们在乳腺癌患者中观察到70.41%的310个区域的C插入(P<0.001, OR = 16.30, 95% CI=7.83-33.93)，而在健康人群中仅存在12.24%。在29.59%的乳腺癌样本中未观察到任何改变。我们还检查了D315区域的突变模式，但没有发现显著的变化(P=1.00)。结论:这是第一个来自孟加拉国乳腺癌(BC)患者的研究，表明D310突变频率相对较高，这表明D310 mtDNA不稳定可能是BC的共同特征，研究还支持mtDNA D310筛查可能代表乳腺癌预后的额外血液生物标志物的假设。
{"title":"Rapid Screening of Blood Mitochondrial D310 and D315 Mutations in Breast Cancer Patients","authors":"F. Akter, S. H. Israfil, Mohammad Ali, A. Rouf, M. Alam, M. Rahman, G. Sultana","doi":"10.12691/JCRT-8-1-1","DOIUrl":"https://doi.org/10.12691/JCRT-8-1-1","url":null,"abstract":"Aims: 'Poly C' stretch extending from 303 to 315 nucleotide positions known as (D310) by GeneBank within the non-coding region HVR-II of mitochondrial DNA (mtDNA) has been identified as a mutational hotspot of primary cancer. We aimed to find this mutation in Bangladeshi breast cancer patients and control samples for screening the changes in poly C stretches. Materials and Methods: We have analyzed a total of 98 breast cancer blood samples and 98 healthy control blood samples and extracted DNA from blood samples for direct sequencing using ABI®3130 Genetic Analyzer. Results: We observed 70.41% C insertion at 310 regions (P<0.001, OR = 16.30 and 95% CI=7.83-33.93) in breast cancer patient whereas it is present only in 12.24% healthy individuals. No alterations were observed in 29.59% breast cancer samples. We also check the mutation pattern at D315 regions, but no significant observation was found (P=1.00). Conclusions: This is the first study from Bangladeshi breast cancer (BC) patients indicating a relatively high frequency of D310 mutations, which suggests that mtDNA instability at D310 may be a common characteristic of BC, study also supports the hypothesis that mtDNA D310 screening may represent additional blood based biomarker for breast cancer prognosis.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"37 1","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2020-05-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"81084344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-05-11DOI: 10.12677/wjcr.2020.103008
李苗皊, 阿吉古丽·麦麦提敏, 阿比达·阿布都卡德尔
{"title":"Discussion on the Application Value of Coagulation and Blood Lipid in Endometrial Carcinoma","authors":"李苗皊, 阿吉古丽·麦麦提敏, 阿比达·阿布都卡德尔","doi":"10.12677/wjcr.2020.103008","DOIUrl":"https://doi.org/10.12677/wjcr.2020.103008","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"284 1","pages":"53-58"},"PeriodicalIF":0.0,"publicationDate":"2020-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73050532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-03-27DOI: 10.12677/wjcr.2020.102006
奇贤 张
{"title":"Research Progress of Ultra-High Dose Rate Radiotherapy (FLASH-RT)","authors":"奇贤 张","doi":"10.12677/wjcr.2020.102006","DOIUrl":"https://doi.org/10.12677/wjcr.2020.102006","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"54 1","pages":"41-46"},"PeriodicalIF":0.0,"publicationDate":"2020-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"73490394","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2684-1266.20.6.126
S. Vale
Adenoid cystic carcinoma is a rare form of adenocarcinoma, which is a type of cancer. It can exist in many different body sites and most often occurs in the areas of the head and neck in particular the salivary glands. Adenoid cystic carcinoma has also been reported in the breast, lacrimal gland of the eye, lung, brain, bartholin gland, and trachea. Here symptoms, diagnosis and treatment of Adenoid Cystic Carcinoma (AdCC) are discussed.
{"title":"Adenoid Cystic Carcinoma-Symptoms, Diagnosis and Treatment","authors":"S. Vale","doi":"10.35248/2684-1266.20.6.126","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.126","url":null,"abstract":"Adenoid cystic carcinoma is a rare form of adenocarcinoma, which is a type of cancer. It can exist in many different body sites and most often occurs in the areas of the head and neck in particular the salivary glands. Adenoid cystic carcinoma has also been reported in the breast, lacrimal gland of the eye, lung, brain, bartholin gland, and trachea. Here symptoms, diagnosis and treatment of Adenoid Cystic Carcinoma (AdCC) are discussed.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"4 1","pages":"1-2"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"79196500","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.12677/wjcr.2020.104010
林 海祥
{"title":"Open the Therapeutic Revolution Door of Antiviral Antitumor with Improving Body Systemic Nonspecific Immunity","authors":"林 海祥","doi":"10.12677/wjcr.2020.104010","DOIUrl":"https://doi.org/10.12677/wjcr.2020.104010","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"18 1","pages":"65-77"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"85602550","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2684-1266.20.6.127
A. Purkayastha
{"title":"Invasive Lobular Carcinoma (ILC): Symptoms, Diagnosis and Treatment","authors":"A. Purkayastha","doi":"10.35248/2684-1266.20.6.127","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.127","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"82 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"84008733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2684-1266.20.6.121
Anas Alsharawneh, Joy Maddigan
Background: Triage in an emergency department (ED) plays a pivotal role as the volume of ED visitors is unpredictable. All ED patients are triaged to make sure that patients with urgent or life-threatening conditions are seen immediately while others with more stable conditions are safe to wait. Purpose: To examine the Canadian Triage and Acuity Scale (CTAS) guidelines to determine if the urgency of oncological emergencies can be prioritized appropriately using the CTAS guidelines. Methods: We used the Complaint Oriented Triage (COT 2012), which is an interactive computerized CTAS tool, to triage select oncological emergencies; superior vena cava syndrome, cardiac tamponade, tumor lysis syndrome, and febrile neutropenia. Results: Patients with cancer have a higher acuity compared to many other ED patients. However, most of the oncological emergencies can be subtle and nonspecific. The CTAS guidelines need to be strengthened to better represent the urgency of these life-threatening conditions. Conclusion: Although revisions have been implemented and the reliability of the CTAS tool has improved, the guidelines are designed to be generic and cannot address every health situation. Febrile neutropenia is an excellent example of the additional supports needed at triage to accurately determine the patient’s health status. Knowledge of the signs and symptoms of these emergencies will enable triage nurses to accurately differentiate the urgency of the different presenting complaints. Formalized education that prepares triage nurses to better understand the complexity of the symptom presentation and the needed care for patients with different oncological emergencies is essential.
{"title":"Do the Canadian Triage Guidelines Identify the Urgency of Oncological Emergencies","authors":"Anas Alsharawneh, Joy Maddigan","doi":"10.35248/2684-1266.20.6.121","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.121","url":null,"abstract":"Background: Triage in an emergency department (ED) plays a pivotal role as the volume of ED visitors is unpredictable. All ED patients are triaged to make sure that patients with urgent or life-threatening conditions are seen immediately while others with more stable conditions are safe to wait. Purpose: To examine the Canadian Triage and Acuity Scale (CTAS) guidelines to determine if the urgency of oncological emergencies can be prioritized appropriately using the CTAS guidelines. Methods: We used the Complaint Oriented Triage (COT 2012), which is an interactive computerized CTAS tool, to triage select oncological emergencies; superior vena cava syndrome, cardiac tamponade, tumor lysis syndrome, and febrile neutropenia. Results: Patients with cancer have a higher acuity compared to many other ED patients. However, most of the oncological emergencies can be subtle and nonspecific. The CTAS guidelines need to be strengthened to better represent the urgency of these life-threatening conditions. Conclusion: Although revisions have been implemented and the reliability of the CTAS tool has improved, the guidelines are designed to be generic and cannot address every health situation. Febrile neutropenia is an excellent example of the additional supports needed at triage to accurately determine the patient’s health status. Knowledge of the signs and symptoms of these emergencies will enable triage nurses to accurately differentiate the urgency of the different presenting complaints. Formalized education that prepares triage nurses to better understand the complexity of the symptom presentation and the needed care for patients with different oncological emergencies is essential.","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"3 1","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"83399085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.12677/wjcr.2020.103009
王 炯杰
{"title":"Clinical Indication Analysis of Avoiding Chest Tube Placement after Lobectomia Pulmonalis","authors":"王 炯杰","doi":"10.12677/wjcr.2020.103009","DOIUrl":"https://doi.org/10.12677/wjcr.2020.103009","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"99 ","pages":"59-63"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91444397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.12677/wjcr.2020.102007
维军 柳
{"title":"Clinical Value of DNA Ploidy Analysis in the Diagnosis of Bronchial Malignancy","authors":"维军 柳","doi":"10.12677/wjcr.2020.102007","DOIUrl":"https://doi.org/10.12677/wjcr.2020.102007","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"38 1","pages":"47-51"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"91392161","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2020-01-01DOI: 10.35248/2684-1266.20.6.E104
Xiaowei Liu
{"title":"Latest updates in Cancer and Immuno-oncology","authors":"Xiaowei Liu","doi":"10.35248/2684-1266.20.6.E104","DOIUrl":"https://doi.org/10.35248/2684-1266.20.6.E104","url":null,"abstract":"","PeriodicalId":22619,"journal":{"name":"The Journal of Cancer Research","volume":"6 1","pages":"1-1"},"PeriodicalIF":0.0,"publicationDate":"2020-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"74380016","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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