Pub Date : 2026-01-08DOI: 10.1016/j.healun.2026.01.001
Michael P Combs,Ciara M Shaver
{"title":"Emerging from the shadows: reading between the lines to illuminate the microbiome's role in CLAD.","authors":"Michael P Combs,Ciara M Shaver","doi":"10.1016/j.healun.2026.01.001","DOIUrl":"https://doi.org/10.1016/j.healun.2026.01.001","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145947425","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-07DOI: 10.1016/j.healun.2025.12.027
B U Baldan,M C van de Veerdonk,P R Tuinman,A E Engström,S Eberl,J P S Henriques,R J M Klautz,P Klein
BACKGROUND AND AIMSPost-cardiotomy shock (PCS) is a severe complication after cardiac surgery, associated with high in-hospital mortality. The Society for Cardiovascular Angiography and Interventions (SCAI) SHOCK classification offers a valid approach for initial shock staging post-surgery. However, the prognostic value and accuracy of serial staging remain unclear. The aim of this study is to externally validate the prognostic value and accuracy of serial SCAI SHOCK reclassification for all-cause in-hospital mortality in PCS patients during postoperative days one-seven.METHODSRetrospective, observational, multicenter study of 9,258 adult post-cardiotomy patients from two Dutch tertiary centers (2015-2024). SCAI SHOCK stage was determined daily during postoperative days one-seven. Endpoint was all-cause in-hospital mortality. Discrimination was performed with area under the curve (AUC) determination, calibration and survival analyses.RESULTSOn postoperative day one, 38% of all post-cardiotomy patients were classified as in shock (stage C-E) and by postoperative day three 91% of all patients were reclassified as not in shock anymore (stage A-B). In-hospital mortality increased progressively with both higher shock stages and prolonged shock duration. SCAI SHOCK classification showed a strong discrimination for in-hospital mortality between postoperative days one and seven with AUC ranging 0.82-0.85. Calibration of the SCAI SHOCK classification improved daily.CONCLUSIONSSerial SCAI SHOCK classification demonstrated consistent good accuracy and enhanced discrimination over time to predict in-hospital mortality in PCS. In-hospital mortality increased progressively with both higher shock stages and prolonged shock duration. Serial SCAI SHOCK assessment provides additional prognostic value over only initial postoperative staging.
{"title":"Serial Assessment of Modified SCAI SHOCK Classification in Post-Cardiotomy Patients.","authors":"B U Baldan,M C van de Veerdonk,P R Tuinman,A E Engström,S Eberl,J P S Henriques,R J M Klautz,P Klein","doi":"10.1016/j.healun.2025.12.027","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.027","url":null,"abstract":"BACKGROUND AND AIMSPost-cardiotomy shock (PCS) is a severe complication after cardiac surgery, associated with high in-hospital mortality. The Society for Cardiovascular Angiography and Interventions (SCAI) SHOCK classification offers a valid approach for initial shock staging post-surgery. However, the prognostic value and accuracy of serial staging remain unclear. The aim of this study is to externally validate the prognostic value and accuracy of serial SCAI SHOCK reclassification for all-cause in-hospital mortality in PCS patients during postoperative days one-seven.METHODSRetrospective, observational, multicenter study of 9,258 adult post-cardiotomy patients from two Dutch tertiary centers (2015-2024). SCAI SHOCK stage was determined daily during postoperative days one-seven. Endpoint was all-cause in-hospital mortality. Discrimination was performed with area under the curve (AUC) determination, calibration and survival analyses.RESULTSOn postoperative day one, 38% of all post-cardiotomy patients were classified as in shock (stage C-E) and by postoperative day three 91% of all patients were reclassified as not in shock anymore (stage A-B). In-hospital mortality increased progressively with both higher shock stages and prolonged shock duration. SCAI SHOCK classification showed a strong discrimination for in-hospital mortality between postoperative days one and seven with AUC ranging 0.82-0.85. Calibration of the SCAI SHOCK classification improved daily.CONCLUSIONSSerial SCAI SHOCK classification demonstrated consistent good accuracy and enhanced discrimination over time to predict in-hospital mortality in PCS. In-hospital mortality increased progressively with both higher shock stages and prolonged shock duration. Serial SCAI SHOCK assessment provides additional prognostic value over only initial postoperative staging.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145937820","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-06DOI: 10.1016/j.healun.2025.12.004
Jade M Kozuch,Derek Chinn,Kamyar Afshar
{"title":"Belatacept in thoracic transplantation: Safety signals from lung recipients.","authors":"Jade M Kozuch,Derek Chinn,Kamyar Afshar","doi":"10.1016/j.healun.2025.12.004","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.004","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"35 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145986562","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-03DOI: 10.1016/j.healun.2025.12.030
Roni Bitterman, Aida Glembocki, Laura N. Walti, Shahid Husain, Petros Pechlivanoglou
{"title":"Preventing Invasive Aspergillosis in Lung Transplant Recipients: A Cost-Utility Analysis","authors":"Roni Bitterman, Aida Glembocki, Laura N. Walti, Shahid Husain, Petros Pechlivanoglou","doi":"10.1016/j.healun.2025.12.030","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.030","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893930","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2026-01-02DOI: 10.1016/j.healun.2025.12.015
Michael Perch, Don Hayes, Wida S. Cherikh, Alexandra Lewis, Lucinda Ewing, Eileen Hsich, Tajinder P. Singh, Göran Dellgren, Rebecca Cogswell
{"title":"Letter to the Editor Re: Commentary from the Melbourne Lung Transplant Group on the 2025 ISHLT Adult Lung Transplant DCD Report","authors":"Michael Perch, Don Hayes, Wida S. Cherikh, Alexandra Lewis, Lucinda Ewing, Eileen Hsich, Tajinder P. Singh, Göran Dellgren, Rebecca Cogswell","doi":"10.1016/j.healun.2025.12.015","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.015","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"26 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893932","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Response to “Comment on ‘Impact of right ventricular reserve function during exercise on aortic valve opening in patients with left ventricular assist device”","authors":"Sakae Takenaka, Takuma Sato, Toshiyuki Nagai, Toshihisa Anzai","doi":"10.1016/j.healun.2025.12.026","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.026","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"17 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2026-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145893931","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-27DOI: 10.1016/j.healun.2025.12.021
Daniel N. Silverman, Ahmed A. Ismail, Lauren Wakefield, Catalin F. Baicu, Rachel Biggs, An O. Van Laer, Lucas J. Witer, Arman Kilic, Brian A. Houston, Amy D. Bradshaw, Michael R. Zile
{"title":"Mechanical Stretch Reduces Fibroblast Activation in Heart Failure with Reduced Ejection Fraction","authors":"Daniel N. Silverman, Ahmed A. Ismail, Lauren Wakefield, Catalin F. Baicu, Rachel Biggs, An O. Van Laer, Lucas J. Witer, Arman Kilic, Brian A. Houston, Amy D. Bradshaw, Michael R. Zile","doi":"10.1016/j.healun.2025.12.021","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.021","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-27DOI: 10.1016/j.healun.2025.12.022
Fulin Wang, Eliana Lucchinettim, Phing-How Lou, Darren H. Freed, Michael Zaugg
{"title":"Left ventricular transcriptome and extracellular vesicle-derived miRNAs in porcine donation after circulatory death (DCD) hearts undergoing prolonged working mode ex situ perfusion","authors":"Fulin Wang, Eliana Lucchinettim, Phing-How Lou, Darren H. Freed, Michael Zaugg","doi":"10.1016/j.healun.2025.12.022","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.022","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"14 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-26DOI: 10.1016/j.healun.2025.12.019
Juka S Kim, Taylor K Brashear, Briana Collins, Hannah Valantine, Kiran K Khush, Natalie Tapaskar, Stephanie Hsiao, Joyce N Njoroge
{"title":"Cardiac Allograft Vasculopathy in the Era of Precision Medicine: The Role of Biomarkers and Advanced Imaging","authors":"Juka S Kim, Taylor K Brashear, Briana Collins, Hannah Valantine, Kiran K Khush, Natalie Tapaskar, Stephanie Hsiao, Joyce N Njoroge","doi":"10.1016/j.healun.2025.12.019","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.019","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"19 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145844819","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-24DOI: 10.1016/j.healun.2025.12.017
Jessica Santilli, Elaine Reguera-Nuñez, Eric Armstrong, Zonelle Wijesinha, Liran Levy, Pierre H.H. Schneeberger, Rayoun Ramendra, Chen Yang Kevin Zhang, Ella Huszti, Tereza Martinu, Bryan Coburn
{"title":"Lung microbiome quantification and bacterial density as prognostic markers in lung transplantation","authors":"Jessica Santilli, Elaine Reguera-Nuñez, Eric Armstrong, Zonelle Wijesinha, Liran Levy, Pierre H.H. Schneeberger, Rayoun Ramendra, Chen Yang Kevin Zhang, Ella Huszti, Tereza Martinu, Bryan Coburn","doi":"10.1016/j.healun.2025.12.017","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.017","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"9 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822906","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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