Pub Date : 2025-12-24DOI: 10.1016/j.healun.2025.12.016
Stefan Schwarz, Konrad Hoetzenecker
{"title":"New Lungs, New Risks – the High-Stakes Challenge of Post-Transplant Lung Cancer","authors":"Stefan Schwarz, Konrad Hoetzenecker","doi":"10.1016/j.healun.2025.12.016","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.016","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"118 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145822905","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-23DOI: 10.1016/j.healun.2025.12.011
Joakim Håkansson, Kristján Jónsson, Bengt Bern, Göran Dellgren
{"title":"Cutaneous integration of a new wireless transcutaneous energy transfer system for durable long-term Ventricular Assist Device systems in an experimental pig model","authors":"Joakim Håkansson, Kristján Jónsson, Bengt Bern, Göran Dellgren","doi":"10.1016/j.healun.2025.12.011","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.011","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145823824","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-20DOI: 10.1016/j.healun.2025.12.008
Brian Yang, Hrishikesh S. Kulkarni
{"title":"Taming the Immaturity of Neutrophils Driving Injury in Lung Transplantation","authors":"Brian Yang, Hrishikesh S. Kulkarni","doi":"10.1016/j.healun.2025.12.008","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.008","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"18 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-20DOI: 10.1016/j.healun.2025.12.013
Norihisa Shigemura, Chadi A Hage
{"title":"Reframing Surgical Decision-Making When Treating Severe Pulmonary Hypertension: Beyond the Binary of Lungs Alone versus Combined Heart-Lung Transplantation","authors":"Norihisa Shigemura, Chadi A Hage","doi":"10.1016/j.healun.2025.12.013","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.013","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"34 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-19DOI: 10.1016/j.healun.2025.12.010
Emilia Maria Swietlik
{"title":"Metabolomic Window Into Right Ventricular-Pulmonary Arterial Coupling","authors":"Emilia Maria Swietlik","doi":"10.1016/j.healun.2025.12.010","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.010","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"41 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145784510","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.healun.2025.12.001
Sophie Saing,Kinan El Husseini,Clément Picard,Tristan Dégot,Benjamin Coiffard,Claire Merveilleux Du Vignaux,Benoit Delarche,Thomas Villeneuve,Morgane Penhouet,Loïc Falque,Véronique Boussaud,Antonin Levy,Vincent De Montpreville,Elie Fadel,Olaf Mercier,Naïssa Abdoul-Anziz,Jérôme Le Pavec,Vincent Bunel,Pauline Pradère
BACKGROUNDLung cancer (LC) after lung transplantation (LTx) is a rare but severe complication whose treatment and outcomes remain unclear.METHODSThis multicenter retrospective observational cohort study included consecutive patients diagnosed between 2000-2023 with primary LC after LTx or heart-LTx. Patient characteristics, cancer stage, treatment modalities, and outcomes were analyzed. Survival was assessed using Kaplan-Meier methods. We compared the cohort to control recipients without post-transplantation LC.RESULTSOf 7313 recipients, 143 (2%) developed LC, after a median interval of 5.3 years. Fifty-five cancers (37%) were stage I disease and 53 (35%) metastatic disease. In 60 (42%) patients, curative-intent surgery, predominantly via a thoracotomy (79%) was performed and achieved R0 resection in 53/57 (93%) patients. Day-90 mortality was 5% after lobectomy and 33% after pneumonectomy. Of the 31 (21%) patients given curative-intent radiotherapy, three developed radiation-induced grade 3 or 4 lung toxicity. Median overall survival in patients with stage I, II, III, and IV disease was 83, 16, 10, and 6 months, respectively. Compared to controls, patients with LC were older at transplantation, had greater donor and recipient smoking exposure, and more often received single-LTx (43% vs. 16%). Of the 62 single-LTx recipients, 52 (84%) had LC in the native lung.CONCLUSIONSCurative-intent surgical resection, when avoiding pneumonectomy, and radiotherapy yield good long-term survival in early-stage post-transplantation LC. The dramatic survival differences between early and advanced stages emphasize the critical importance of routine low-dose computed tomography screening in all recipients, notably after single-LTx.
{"title":"Lung Cancer After Lung Transplantation: Early Detection and Curative Surgery Drive Long-Term Survival.","authors":"Sophie Saing,Kinan El Husseini,Clément Picard,Tristan Dégot,Benjamin Coiffard,Claire Merveilleux Du Vignaux,Benoit Delarche,Thomas Villeneuve,Morgane Penhouet,Loïc Falque,Véronique Boussaud,Antonin Levy,Vincent De Montpreville,Elie Fadel,Olaf Mercier,Naïssa Abdoul-Anziz,Jérôme Le Pavec,Vincent Bunel,Pauline Pradère","doi":"10.1016/j.healun.2025.12.001","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.001","url":null,"abstract":"BACKGROUNDLung cancer (LC) after lung transplantation (LTx) is a rare but severe complication whose treatment and outcomes remain unclear.METHODSThis multicenter retrospective observational cohort study included consecutive patients diagnosed between 2000-2023 with primary LC after LTx or heart-LTx. Patient characteristics, cancer stage, treatment modalities, and outcomes were analyzed. Survival was assessed using Kaplan-Meier methods. We compared the cohort to control recipients without post-transplantation LC.RESULTSOf 7313 recipients, 143 (2%) developed LC, after a median interval of 5.3 years. Fifty-five cancers (37%) were stage I disease and 53 (35%) metastatic disease. In 60 (42%) patients, curative-intent surgery, predominantly via a thoracotomy (79%) was performed and achieved R0 resection in 53/57 (93%) patients. Day-90 mortality was 5% after lobectomy and 33% after pneumonectomy. Of the 31 (21%) patients given curative-intent radiotherapy, three developed radiation-induced grade 3 or 4 lung toxicity. Median overall survival in patients with stage I, II, III, and IV disease was 83, 16, 10, and 6 months, respectively. Compared to controls, patients with LC were older at transplantation, had greater donor and recipient smoking exposure, and more often received single-LTx (43% vs. 16%). Of the 62 single-LTx recipients, 52 (84%) had LC in the native lung.CONCLUSIONSCurative-intent surgical resection, when avoiding pneumonectomy, and radiotherapy yield good long-term survival in early-stage post-transplantation LC. The dramatic survival differences between early and advanced stages emphasize the critical importance of routine low-dose computed tomography screening in all recipients, notably after single-LTx.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-16DOI: 10.1016/j.healun.2025.11.028
Baharan Zarrabian,Kelly M Pennington,Hector R Cajigas,Hilary M DuBrock,Cassie Kennedy,Robert Frantz,Sudhir Kushwaha,Mauricio A Villavicencio,Sahar A Saddoughi
BACKGROUNDIn end-stage primary pulmonary arterial hypertension (PAH), chronically elevated pulmonary vascular resistance leads to right ventricular (RV) hypertrophy, dilation, and failure, complicating transplant decision-making. Surgical options include bilateral lung and heart-lung transplantation, but optimal strategy remains debated.METHODSWe conducted a retrospective cohort study using the Organ Procurement and Transplantation Network (OPTN) to identify adults (≥18 years) who underwent bilateral lung or heart-lung transplantation for PAH between June 30, 2004, and September 30, 2022. Patients with congenital or structural cardiac abnormalities were excluded. Baseline demographics, comorbidities, hemodynamics, perioperative course, and survival were compared by transplant type. The primary outcome was one-year mortality; the secondary outcome was five-year mortality.RESULTSOf 914 PAH recipients, 776 (84.9%) underwent bilateral lung and 138 (15.1%) underwent heart-lung transplantation. Bilateral lung recipients had higher cardiac index (2.4 vs. 2.2 L/min/m², P = 0.02) and lower pulmonary capillary wedge pressure (11 vs. 13 mmHg, P < 0.001). They were more likely to require extracorporeal membrane oxygenation (ECMO) at 72 hours (24.2% vs. 10.8%, P = 0.02) and remain intubated (43.0% vs. 23.9%, P < 0.001). Survival was similar between groups. Heart-lung transplantation was not associated with increased mortality at one year (adjusted hazard ratio [HR] 1.82, 95% CI 0.89-3.71, P = 0.10) or five years (HR 1.49, 95% CI 0.87-2.54, P = 0.14). Findings were consistent across hemodynamic subgroups.CONCLUSIONSIn PAH, bilateral lung transplantation achieves comparable one- and five-year survival to heart-lung transplantation, supporting its role as a viable alternative in appropriately selected patients.
在终末期原发性肺动脉高压（PAH）患者中，长期升高的肺血管阻力会导致右心室（RV）肥大、扩张和衰竭，使移植决策复杂化。手术选择包括双侧肺和心肺移植，但最佳策略仍有争议。方法：我们利用器官获取和移植网络（OPTN）进行了一项回顾性队列研究，以确定2004年6月30日至2022年9月30日期间因PAH接受双侧肺或心肺移植的成年人（≥18岁）。排除先天性或结构性心脏异常患者。基线人口统计学、合并症、血流动力学、围手术期和生存率按移植类型进行比较。主要结局为1年死亡率；次要终点是5年死亡率。结果914例PAH患者中，776例（84.9%）行双侧肺移植，138例（15.1%）行心肺移植。双侧肺受体心脏指数较高（2.4 vs 2.2 L/min/m²，P = 0.02），肺毛细血管楔压较低（11 vs 13 mmHg, P < 0.001）。他们更有可能在72小时内需要体外膜氧合（ECMO） （24.2% vs. 10.8%, P = 0.02）并继续插管（43.0% vs. 23.9%, P < 0.001）。两组之间的存活率相似。心肺移植与1年（校正风险比[HR] 1.82, 95% CI 0.89-3.71, P = 0.10）或5年（HR 1.49, 95% CI 0.87-2.54, P = 0.14）死亡率增加无关。各血流动力学亚组的结果一致。结论：在PAH患者中，双侧肺移植的1年和5年生存率与心肺移植相当，支持其在适当选择的患者中作为可行的替代方案。
{"title":"Comparative Outcomes of Bilateral Lung and Heart-Lung Transplantation in Primary Pulmonary Arterial Hypertension: A UNOS Database Study.","authors":"Baharan Zarrabian,Kelly M Pennington,Hector R Cajigas,Hilary M DuBrock,Cassie Kennedy,Robert Frantz,Sudhir Kushwaha,Mauricio A Villavicencio,Sahar A Saddoughi","doi":"10.1016/j.healun.2025.11.028","DOIUrl":"https://doi.org/10.1016/j.healun.2025.11.028","url":null,"abstract":"BACKGROUNDIn end-stage primary pulmonary arterial hypertension (PAH), chronically elevated pulmonary vascular resistance leads to right ventricular (RV) hypertrophy, dilation, and failure, complicating transplant decision-making. Surgical options include bilateral lung and heart-lung transplantation, but optimal strategy remains debated.METHODSWe conducted a retrospective cohort study using the Organ Procurement and Transplantation Network (OPTN) to identify adults (≥18 years) who underwent bilateral lung or heart-lung transplantation for PAH between June 30, 2004, and September 30, 2022. Patients with congenital or structural cardiac abnormalities were excluded. Baseline demographics, comorbidities, hemodynamics, perioperative course, and survival were compared by transplant type. The primary outcome was one-year mortality; the secondary outcome was five-year mortality.RESULTSOf 914 PAH recipients, 776 (84.9%) underwent bilateral lung and 138 (15.1%) underwent heart-lung transplantation. Bilateral lung recipients had higher cardiac index (2.4 vs. 2.2 L/min/m², P = 0.02) and lower pulmonary capillary wedge pressure (11 vs. 13 mmHg, P < 0.001). They were more likely to require extracorporeal membrane oxygenation (ECMO) at 72 hours (24.2% vs. 10.8%, P = 0.02) and remain intubated (43.0% vs. 23.9%, P < 0.001). Survival was similar between groups. Heart-lung transplantation was not associated with increased mortality at one year (adjusted hazard ratio [HR] 1.82, 95% CI 0.89-3.71, P = 0.10) or five years (HR 1.49, 95% CI 0.87-2.54, P = 0.14). Findings were consistent across hemodynamic subgroups.CONCLUSIONSIn PAH, bilateral lung transplantation achieves comparable one- and five-year survival to heart-lung transplantation, supporting its role as a viable alternative in appropriately selected patients.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"25 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145777430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1016/j.healun.2025.12.007
Adelaida Bosacoma, Agustín R. Garcia, Juan-José Lozano, Julia Sidorova, Olga Tura-Ceide, Isabel Blanco, Ylenia Roger, Anna Sardiné, Clara Martín-Ontiyuelo, Diego A. Rodríguez-Chiaradía, Manuel López-Meseguer, Fernanda Hernandez-Gonzalez, Jesús Ribas, Xavier Pomares, Salud Santos, María Molina-Molina, Jacobo Sellares, Victor I. Peinado, Joan A. Barberà
{"title":"Distinct Plasma Proteome in Severe Pulmonary Hypertension Associated with Chronic Lung Disease","authors":"Adelaida Bosacoma, Agustín R. Garcia, Juan-José Lozano, Julia Sidorova, Olga Tura-Ceide, Isabel Blanco, Ylenia Roger, Anna Sardiné, Clara Martín-Ontiyuelo, Diego A. Rodríguez-Chiaradía, Manuel López-Meseguer, Fernanda Hernandez-Gonzalez, Jesús Ribas, Xavier Pomares, Salud Santos, María Molina-Molina, Jacobo Sellares, Victor I. Peinado, Joan A. Barberà","doi":"10.1016/j.healun.2025.12.007","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.007","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"52 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731937","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1016/j.healun.2025.12.002
Andrea Fernandez Valledor, Cathrine M. Moeller, Daniel Oren, Salwa Rahman, Adi Hertz, Julia Baranowska, Carolyn Hennecken, Afsana Rahman, Boaz Elad, Ilan Richter, Dor Lotan, Adil Yunis, Justin Fried, Ersilia M. DeFilippis, Jayant Raihkelkar, Farhana Latif, Kevin D. Clerkin, David T. Majure, Gabriel T. Sayer, Nir Uriel
{"title":"Enhanced Detection of Antibody-Mediated Rejection Using the Tissue-Based Molecular Microscope Diagnostic System (MMDx)","authors":"Andrea Fernandez Valledor, Cathrine M. Moeller, Daniel Oren, Salwa Rahman, Adi Hertz, Julia Baranowska, Carolyn Hennecken, Afsana Rahman, Boaz Elad, Ilan Richter, Dor Lotan, Adil Yunis, Justin Fried, Ersilia M. DeFilippis, Jayant Raihkelkar, Farhana Latif, Kevin D. Clerkin, David T. Majure, Gabriel T. Sayer, Nir Uriel","doi":"10.1016/j.healun.2025.12.002","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.002","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"150 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145732670","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-12-12DOI: 10.1016/j.healun.2025.12.003
Paul J Scheel, Steven Hsu
{"title":"Less RV Contractility but More Afterload after LVAD: How Two Wrongs Ache the Right","authors":"Paul J Scheel, Steven Hsu","doi":"10.1016/j.healun.2025.12.003","DOIUrl":"https://doi.org/10.1016/j.healun.2025.12.003","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"6 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145731067","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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