Pub Date : 2025-01-17DOI: 10.1016/j.healun.2025.01.009
Rachna Kataria,Claudius Mahr
{"title":"Improving Outcomes in Cardiogenic Shock: A Focus on Reducing Complications.","authors":"Rachna Kataria,Claudius Mahr","doi":"10.1016/j.healun.2025.01.009","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.009","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"10 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991704","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
BACKGROUNDThe Advanced Cardiac Therapies Improving Outcomes Network (ACTION) began in 2018 as a collaborative learning health system committed to improving outcomes in pediatric heart failure, including children and adults with congenital heart disease, supported with ventricular assist devices (VADs). This report describes patient and device characteristics, and outcomes through 1-year post-implant.METHODSThe ACTION VAD registry report was created from data submitted to the ACTION learning network from April 2018-June 2023. It includes 1,430 devices implanted in 1,220 pediatric patients (<18) from 57 sites across North America.RESULTSMales comprised 55% of the registry patients. The median age was 3.7 years with a median implant weight of 13.6 kg; 36% of the cohort was <10 kg. Nearly 40% of patients had a primary diagnosis of congenital heart disease (CHD). Patients with CHD represented 26% of VAD implants in 2018 which increased to 42% in 2023 (p=0.03). At implant, 25% of patients were supported with ECMO, 4.9% with dialysis, and 54% were mechanically ventilated. Paracorporeal pulsatile pumps comprised 40.2% of implants, followed in incidence by paracorporeal continuous flow (28.5%), and implantable continuous flow (24.1%). The number of patients in the VAD Registry patients increased from 102 in 2018 to 256 in 2022, partly reflecting increased center participation in ACTION. Overall survival on support at 1 year was 79.2%, and the incidence of stroke was 13.7%. Infants demonstrated the poorest outcomes, with a 1-year survival of 72.9% and a higher incidence of stroke (20.8%).CONCLUSIONThe five-year ACTION VAD experience highlights the growing collaboration in the pediatric VAD community and changes in clinical practice. More work is needed to improve survival and limit adverse outcomes, especially in younger patients.
{"title":"The ACTION VAD Registry: A Collective Five-Year Experience.","authors":"Jonathan B Edelson,Alexander Raskin,Mohammed Absi,Iki Adachi,Othman Aljohani,Anaam Alzubi,Shahnawaz Amdani,Alfred Asante-Korang,Scott Auerbach,Neha Bansal,David Bearl,Katerina Boucek,Arene Butto,Ryan Butts,Jonathan Byrnes,Chesney Castleberry,Jennifer Conway,Nhue Do,John Dykes,Joshua Friedland-Little,Lawrence Greiten,Heather Henderson,Daphne Hsu,Aamir Jeewa,Anna Joong,Sairah Khan,Christopher Knoll,Jodie Lantz,Sabrina Law,Angela Lorts,Katsuhide Maeda,Hugo Martinez,Lindsay May,Mary Mehegan,Deepa Mokshagundam,Catherine Montgomery,Matthew O'Connor,John Jerry Parent,David Peng,David N Rosenthal,Aryaz Sheybani,Muhammad Shezad,Lana Shugh,Natalie Shwaish,Joseph Spinner,Jennifer Su,David Sutcliffe,Hari Tunuguntla,Christina VanderPluym,Gabrielle Vaughn,Gonzalo Wallis,Sarah Wilkens,Matthew Zinn,Robert Niebler,","doi":"10.1016/j.healun.2025.01.007","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.007","url":null,"abstract":"BACKGROUNDThe Advanced Cardiac Therapies Improving Outcomes Network (ACTION) began in 2018 as a collaborative learning health system committed to improving outcomes in pediatric heart failure, including children and adults with congenital heart disease, supported with ventricular assist devices (VADs). This report describes patient and device characteristics, and outcomes through 1-year post-implant.METHODSThe ACTION VAD registry report was created from data submitted to the ACTION learning network from April 2018-June 2023. It includes 1,430 devices implanted in 1,220 pediatric patients (<18) from 57 sites across North America.RESULTSMales comprised 55% of the registry patients. The median age was 3.7 years with a median implant weight of 13.6 kg; 36% of the cohort was <10 kg. Nearly 40% of patients had a primary diagnosis of congenital heart disease (CHD). Patients with CHD represented 26% of VAD implants in 2018 which increased to 42% in 2023 (p=0.03). At implant, 25% of patients were supported with ECMO, 4.9% with dialysis, and 54% were mechanically ventilated. Paracorporeal pulsatile pumps comprised 40.2% of implants, followed in incidence by paracorporeal continuous flow (28.5%), and implantable continuous flow (24.1%). The number of patients in the VAD Registry patients increased from 102 in 2018 to 256 in 2022, partly reflecting increased center participation in ACTION. Overall survival on support at 1 year was 79.2%, and the incidence of stroke was 13.7%. Infants demonstrated the poorest outcomes, with a 1-year survival of 72.9% and a higher incidence of stroke (20.8%).CONCLUSIONThe five-year ACTION VAD experience highlights the growing collaboration in the pediatric VAD community and changes in clinical practice. More work is needed to improve survival and limit adverse outcomes, especially in younger patients.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"45 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991700","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-17DOI: 10.1016/j.healun.2025.01.001
Marius Berman
{"title":"Thoraco Abdominal Normothermic Regional Perfusion and Lung Transplantation - Is it a Safe Match?","authors":"Marius Berman","doi":"10.1016/j.healun.2025.01.001","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.001","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"37 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991667","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.healun.2025.01.004
Scott C Silvestry
{"title":"What We Know We Don't Know: The Johari Window in DCD Heart Transplantation.","authors":"Scott C Silvestry","doi":"10.1016/j.healun.2025.01.004","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.004","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"70 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.healun.2025.01.008
Cole J Buchanan,Ryan J Tedford
{"title":"Stressing the People's Ventricle: Exercise 3D Echocardiography to Evaluate Right Ventricular Reserve.","authors":"Cole J Buchanan,Ryan J Tedford","doi":"10.1016/j.healun.2025.01.008","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.008","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"58 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-16DOI: 10.1016/j.healun.2025.01.002
Alice L Zhou,Armaan F Akbar,Alexandra A Rizaldi,Jessica M Ruck,Emily L Larson,Sorush Rokui,Dane C Paneitz,Elizabeth A King,Ahmet Kilic
PURPOSEThe new rescue kidney policy in the United States was implemented in June 2023. To estimate its potential impact, we investigated a historic cohort of heart transplant (HT) recipients who would have been eligible for a kidney-after-heart transplant under this policy.METHODSAdult heart-only recipients from 1/1/2000 to 3/31/2023 in the United Network for Organ Sharing database were categorized by retroactively applying eligibility criteria from the new policy: eGFR≤20mL/min, CrCl≤20mL/min, or dialysis 60-365 days post-HT. We evaluated outcomes of eligible recipients.RESULTSOf 45,833 HT recipients, 840 (1.8%) were eligible for a rescue kidney. Eligible recipients had higher median age (58 vs. 56 years, p<0.001) and serum creatinine (1.4 vs. 1.2, p<0.001), and were more likely to be status 1A in the pre-2018 allocation era (63.4% vs. 51.9%, p<0.001) and status 1 in the post-2018 allocation era (13.9% vs. 9.1%, p=0.003). Survival at 1 year conditional on 60-day survival was worse for eligible recipients (50.8% vs. 96.3%; HR 17.6 [95%CI: 15.8-19.6], p<0.001). Post-HT, 607 (72.3%) eligible recipients were never listed for kidney transplant (KT), of whom 486 (80.1%) died with a median time-to-death of 8.8 months. Among the 233 (27.7%) recipients listed for KT, 65 (27.9%) died/deteriorated on the waitlist and 99 (42.5%) received a KT (median 38.4 months post-HT).CONCLUSIONSHalf of recipients eligible for a rescue kidney did not survive to 1 year post-HT, and >70% were never listed for KT. The effects of the new policy on mitigating mortality in this challenging population will be paramount.
{"title":"New Kidney-After-Heart Allocation Policy in the United States: Who would benefit from a rescue kidney?","authors":"Alice L Zhou,Armaan F Akbar,Alexandra A Rizaldi,Jessica M Ruck,Emily L Larson,Sorush Rokui,Dane C Paneitz,Elizabeth A King,Ahmet Kilic","doi":"10.1016/j.healun.2025.01.002","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.002","url":null,"abstract":"PURPOSEThe new rescue kidney policy in the United States was implemented in June 2023. To estimate its potential impact, we investigated a historic cohort of heart transplant (HT) recipients who would have been eligible for a kidney-after-heart transplant under this policy.METHODSAdult heart-only recipients from 1/1/2000 to 3/31/2023 in the United Network for Organ Sharing database were categorized by retroactively applying eligibility criteria from the new policy: eGFR≤20mL/min, CrCl≤20mL/min, or dialysis 60-365 days post-HT. We evaluated outcomes of eligible recipients.RESULTSOf 45,833 HT recipients, 840 (1.8%) were eligible for a rescue kidney. Eligible recipients had higher median age (58 vs. 56 years, p<0.001) and serum creatinine (1.4 vs. 1.2, p<0.001), and were more likely to be status 1A in the pre-2018 allocation era (63.4% vs. 51.9%, p<0.001) and status 1 in the post-2018 allocation era (13.9% vs. 9.1%, p=0.003). Survival at 1 year conditional on 60-day survival was worse for eligible recipients (50.8% vs. 96.3%; HR 17.6 [95%CI: 15.8-19.6], p<0.001). Post-HT, 607 (72.3%) eligible recipients were never listed for kidney transplant (KT), of whom 486 (80.1%) died with a median time-to-death of 8.8 months. Among the 233 (27.7%) recipients listed for KT, 65 (27.9%) died/deteriorated on the waitlist and 99 (42.5%) received a KT (median 38.4 months post-HT).CONCLUSIONSHalf of recipients eligible for a rescue kidney did not survive to 1 year post-HT, and >70% were never listed for KT. The effects of the new policy on mitigating mortality in this challenging population will be paramount.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"1 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142991708","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1016/j.healun.2025.01.006
J L Platt,M Cascalho
{"title":"Piwi-interacting RNAs (piRNAs), potential new liquid biopsy in the immune surveillance of heart transplant recipients.","authors":"J L Platt,M Cascalho","doi":"10.1016/j.healun.2025.01.006","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.006","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"101 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2025-01-15DOI: 10.1016/j.healun.2025.01.003
Michael T Cain
{"title":"Brick by Brick, BOLT by BOLT: Building the Case for DCD Lung Transplant.","authors":"Michael T Cain","doi":"10.1016/j.healun.2025.01.003","DOIUrl":"https://doi.org/10.1016/j.healun.2025.01.003","url":null,"abstract":"","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"7 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142989655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-25DOI: 10.1016/j.healun.2024.12.022
C Baratto,C Dewachter,K Forton,D Muraru,M F Gagliardi,M Tomaselli,M Gavazzoni,G B Perego,M Senni,A Bondue,L P Badano,G Parati,J L Vachiéry,S Caravita
BACKGROUNDRV reserve has been linked to exercise capacity and prognosis in cardiopulmonary diseases. However, evidence in this setting is limited, due to the complex shape and load dependency of the RV. We sought to study right ventricular (RV) adaptation to exercise by simultaneous three-dimensional echocardiography (3DE) and right heart catheterization (RHC).METHODSPatients with heart failure with preserved ejection fraction (HFpEF) or pulmonary vascular disease (PVD) underwent simultaneous supine rest/exercise RHC-3DE. They were subdivided based on RV ejection fraction (EF) changes: 1)exhausted RV reserve, RVEF-; 2)preserved RV reserve, RVEF+.RESULTSSixty percent of patients were RVEF-. Distribution of HFpEF/PVD, as well as RV volumes and RVEF at rest were similar in the two groups. Hemodynamic metrics of RV afterload, as well as their exercise-induced changes, were similar in the two groups. During exercise, RV end-diastolic volume increased more in RVEF- than in RVEF+ (29±29 vs 7±25 mL,p<0.05). RV end-systolic volume increased by 21[12;31]mL in RVEF- and decreased by 8[-15;1]mL in RVEF+ (p<0.001). RV-pulmonary artery coupling was lower in RVEF- at peak exercise(p<0.05). Peak RVEF was associated with left ventricular preload (R2=0.14,p=0.011). Cardiac output increased less in RVEF- than in RVEF+ (+2.3±2.0 vs +4.0±2.4 L/min,p<0.05). Peak RVEF was associated with oxygen consumption(p<0.01).CONCLUSIONSExhausted RV reserve, as evaluated by 3DE, was frequent in HFpEF and PVD, was relatively independent from classical afterload parameters, was associated with RV-pulmonary artery decoupling, RV dilation, enhanced ventricular interdependence, and cardiac limitation to exercise. Intrinsic RV dysfunction may contribute to exhausted RV reserve.
背景：drv储备与心肺疾病患者的运动能力和预后有关。然而，由于RV复杂的形状和载荷依赖性，在这种情况下的证据是有限的。我们试图通过三维超声心动图（3DE）和右心导管（RHC）同时研究右心室（RV）对运动的适应性。方法心力衰竭伴保射血分数（HFpEF）或肺血管疾病（PVD）患者同时进行仰卧休息/运动RHC-3DE。根据右心室射血分数（EF）的变化将其细分为：1)用尽右心室储备，RVEF-；2)保留的RV储备，RVEF+。结果60%的患者为RVEF-。两组患者的HFpEF/PVD分布、静息时RV体积和RVEF相似。两组右心室后负荷的血流动力学指标及其运动引起的变化相似。运动时，RVEF-组右心室舒张末期容积比RVEF+组增大（29±29 vs 7±25 mL,p<0.05）。RVEF-组右心室收缩末容积增加21[12；31]mL， RVEF+组右心室收缩末容积减少8[-15；1]mL （p<0.001）。运动高峰时RVEF-组rv -肺动脉耦合较低（p<0.05）。RVEF峰值与左心室预负荷相关（R2=0.14,p=0.011）。RVEF-组心输出量的增加小于RVEF+组（+2.3±2.0 vs +4.0±2.4 L/min,p<0.05）。RVEF峰值与耗氧量相关（p<0.01）。结论3DE评价的右心室储备衰竭在HFpEF和PVD中较为常见，与经典后负荷参数相对独立，与右心室-肺动脉解耦、右心室扩张、心室相互依赖性增强和心脏对运动的限制有关。内源性右心室功能障碍可能导致右心室储备衰竭。
{"title":"Right ventricular reserve in cardiopulmonary disease: a simultaneous hemodynamic and three-dimensional echocardiographic study.","authors":"C Baratto,C Dewachter,K Forton,D Muraru,M F Gagliardi,M Tomaselli,M Gavazzoni,G B Perego,M Senni,A Bondue,L P Badano,G Parati,J L Vachiéry,S Caravita","doi":"10.1016/j.healun.2024.12.022","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.022","url":null,"abstract":"BACKGROUNDRV reserve has been linked to exercise capacity and prognosis in cardiopulmonary diseases. However, evidence in this setting is limited, due to the complex shape and load dependency of the RV. We sought to study right ventricular (RV) adaptation to exercise by simultaneous three-dimensional echocardiography (3DE) and right heart catheterization (RHC).METHODSPatients with heart failure with preserved ejection fraction (HFpEF) or pulmonary vascular disease (PVD) underwent simultaneous supine rest/exercise RHC-3DE. They were subdivided based on RV ejection fraction (EF) changes: 1)exhausted RV reserve, RVEF-; 2)preserved RV reserve, RVEF+.RESULTSSixty percent of patients were RVEF-. Distribution of HFpEF/PVD, as well as RV volumes and RVEF at rest were similar in the two groups. Hemodynamic metrics of RV afterload, as well as their exercise-induced changes, were similar in the two groups. During exercise, RV end-diastolic volume increased more in RVEF- than in RVEF+ (29±29 vs 7±25 mL,p<0.05). RV end-systolic volume increased by 21[12;31]mL in RVEF- and decreased by 8[-15;1]mL in RVEF+ (p<0.001). RV-pulmonary artery coupling was lower in RVEF- at peak exercise(p<0.05). Peak RVEF was associated with left ventricular preload (R2=0.14,p=0.011). Cardiac output increased less in RVEF- than in RVEF+ (+2.3±2.0 vs +4.0±2.4 L/min,p<0.05). Peak RVEF was associated with oxygen consumption(p<0.01).CONCLUSIONSExhausted RV reserve, as evaluated by 3DE, was frequent in HFpEF and PVD, was relatively independent from classical afterload parameters, was associated with RV-pulmonary artery decoupling, RV dilation, enhanced ventricular interdependence, and cardiac limitation to exercise. Intrinsic RV dysfunction may contribute to exhausted RV reserve.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"12 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887603","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-12-25DOI: 10.1016/j.healun.2024.12.001
Amit H Alam,Candice Y Lee,Manreet K Kanwar,Yasbanoo Moayedi,Alexander M Bernhardt,Koji Takeda,Duc Thinh Pham,Christopher Salerno,Andreas Zuckermann,David D'Alessandro,Victor G Pretorius,John O Louca,Stephen Large,Dawn E Bowles,Scott C Silvestry,Nader Moazami
Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement and recent advancements in donor heart procurement technologies. This State-of-the-Art review will explore factors associated with bringing the "ideal" donor heart to the operating room in the contemporary era.
{"title":"Current Approaches to Optimize Donor Heart for Transplantation.","authors":"Amit H Alam,Candice Y Lee,Manreet K Kanwar,Yasbanoo Moayedi,Alexander M Bernhardt,Koji Takeda,Duc Thinh Pham,Christopher Salerno,Andreas Zuckermann,David D'Alessandro,Victor G Pretorius,John O Louca,Stephen Large,Dawn E Bowles,Scott C Silvestry,Nader Moazami","doi":"10.1016/j.healun.2024.12.001","DOIUrl":"https://doi.org/10.1016/j.healun.2024.12.001","url":null,"abstract":"Heart transplantation remains a critical therapy for patients with end-stage heart failure, offering incremental survival and improved quality of life. One of the key components behind the success of heart transplantation is the condition and preservation of the donor heart. In this review, we provide a comprehensive overview of ischemic reperfusion injury, risk factors associated with primary graft dysfunction, current use of various preservation solutions for organ procurement and recent advancements in donor heart procurement technologies. This State-of-the-Art review will explore factors associated with bringing the \"ideal\" donor heart to the operating room in the contemporary era.","PeriodicalId":22654,"journal":{"name":"The Journal of Heart and Lung Transplantation","volume":"63 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-12-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142887597","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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