Pub Date : 2024-10-16DOI: 10.1016/s1474-4422(24)00356-9
Xin-Yuan Chen
No Abstract
无摘要
{"title":"Multidisciplinary care for rare neurological diseases in China","authors":"Xin-Yuan Chen","doi":"10.1016/s1474-4422(24)00356-9","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00356-9","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"21 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/s1474-4422(24)00407-1
Jinsy A Andrews
No Abstract
无摘要
{"title":"A new era of drug discovery for amyotrophic lateral sclerosis","authors":"Jinsy A Andrews","doi":"10.1016/s1474-4422(24)00407-1","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00407-1","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"29 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/s1474-4422(24)00405-8
Melinda S Kavanaugh
No Abstract
无摘要
{"title":"Supporting young carers across neurological disorders","authors":"Melinda S Kavanaugh","doi":"10.1016/s1474-4422(24)00405-8","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00405-8","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"13 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/s1474-4422(24)00263-1
Yanick J Crow
The ability to mount an interferon-mediated innate immune response is essential in protection against neurotropic viruses, but antiviral type I interferons also have neurotoxic potential. The production of type I interferons can be triggered by self-derived nucleic acids, and the brain can be susceptible to inappropriate upregulation of type I interferon signalling. Homoeostatic dysregulation of type I interferons has been implicated in rare inborn errors of immunity (referred to as type I interferonopathies) and more common neurodegenerative disorders (eg, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis). Recent developments include new insights into the pathogenesis of these disorders that involve dysregulated type I interferon signalling, as well as advances in their diagnosis and management. The role of type I interferons in brain cellular health suggests the future therapeutic potential of approaches that target these interferons and their signalling.
启动干扰素介导的先天性免疫反应的能力对于抵御神经性病毒至关重要，但抗病毒 I 型干扰素也具有潜在的神经毒性。I 型干扰素的产生可由自身产生的核酸触发，大脑很容易受到 I 型干扰素信号不适当上调的影响。I 型干扰素的平衡失调与罕见的先天性免疫错误（称为 I 型干扰素病）和更常见的神经退行性疾病（如帕金森病、阿尔茨海默病和肌萎缩侧索硬化症）有关。最近的研究进展包括对这些涉及 I 型干扰素信号失调的疾病发病机制的新认识，以及在诊断和治疗方面取得的进展。I 型干扰素在脑细胞健康中的作用表明，针对这些干扰素及其信号传导的方法在未来具有治疗潜力。
{"title":"CNS disease associated with enhanced type I interferon signalling","authors":"Yanick J Crow","doi":"10.1016/s1474-4422(24)00263-1","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00263-1","url":null,"abstract":"The ability to mount an interferon-mediated innate immune response is essential in protection against neurotropic viruses, but antiviral type I interferons also have neurotoxic potential. The production of type I interferons can be triggered by self-derived nucleic acids, and the brain can be susceptible to inappropriate upregulation of type I interferon signalling. Homoeostatic dysregulation of type I interferons has been implicated in rare inborn errors of immunity (referred to as type I interferonopathies) and more common neurodegenerative disorders (eg, Parkinson's disease, Alzheimer's disease, and amyotrophic lateral sclerosis). Recent developments include new insights into the pathogenesis of these disorders that involve dysregulated type I interferon signalling, as well as advances in their diagnosis and management. The role of type I interferons in brain cellular health suggests the future therapeutic potential of approaches that target these interferons and their signalling.","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"24 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/s1474-4422(24)00400-9
Shyamala Mani, Angela M Kaindl
No Abstract
无摘要
{"title":"Type I interferonopathies with CNS symptoms","authors":"Shyamala Mani, Angela M Kaindl","doi":"10.1016/s1474-4422(24)00400-9","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00400-9","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"4 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440443","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-16DOI: 10.1016/s1474-4422(24)00361-2
Lina Palaiodimou, Georgios Tsivgoulis
No Abstract
无摘要
{"title":"A new standard for thrombolysis in acute ischaemic stroke","authors":"Lina Palaiodimou, Georgios Tsivgoulis","doi":"10.1016/s1474-4422(24)00361-2","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00361-2","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"44 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142440380","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-10-13DOI: 10.1016/s1474-4422(24)00409-5
Victor Volovici, Marco Cenzato, Torstein R Meling
No Abstract
无摘要
{"title":"The European expertise network for open microvascular surgery","authors":"Victor Volovici, Marco Cenzato, Torstein R Meling","doi":"10.1016/s1474-4422(24)00409-5","DOIUrl":"https://doi.org/10.1016/s1474-4422(24)00409-5","url":null,"abstract":"No Abstract","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"3 1","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-10-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142431635","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-01DOI: 10.1016/S1474-4422(24)00177-7
T. Zonneveld, S. Vermeer, E. W. V. Zwet, A. E. Groot, Ale Algra, L. Aerden, K. Alblas, F. D. Beer, P. J. A. M. Brouwers, K. D. Gans, H. V. Gemert, Bart C A M van Ginneken, Gerke S. Grooters, P. Halkes, Tonny A M H G van der Heijden-Montfroy, K. Jellema, Sonja W de Jong, Harry Lövenich-Ciccarello, W. D. V. D. Meulen, Edwin W Peters, T. C. V. D. Ree, M. Remmers, Edo Richard, Jörgen M P Rovers, Ritu Saxena, S. M. V. Schaik, W. Schonewille, T. Schreuder, E. Schryver, W. Schuiling, Fianne H Spaander, J. V. Tuijl, Marieke C Visser, Sanne M. Zinkstok, E. Zock, D. Dippel, L. J. Kappelle, R. J. V. Oostenbrugge, Y. Roos, F. Vermeij, M. Wermer, H. B. Worp, P. Nederkoorn, N. Kruyt
{"title":"Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study","authors":"T. Zonneveld, S. Vermeer, E. W. V. Zwet, A. E. Groot, Ale Algra, L. Aerden, K. Alblas, F. D. Beer, P. J. A. M. Brouwers, K. D. Gans, H. V. Gemert, Bart C A M van Ginneken, Gerke S. Grooters, P. Halkes, Tonny A M H G van der Heijden-Montfroy, K. Jellema, Sonja W de Jong, Harry Lövenich-Ciccarello, W. D. V. D. Meulen, Edwin W Peters, T. C. V. D. Ree, M. Remmers, Edo Richard, Jörgen M P Rovers, Ritu Saxena, S. M. V. Schaik, W. Schonewille, T. Schreuder, E. Schryver, W. Schuiling, Fianne H Spaander, J. V. Tuijl, Marieke C Visser, Sanne M. Zinkstok, E. Zock, D. Dippel, L. J. Kappelle, R. J. V. Oostenbrugge, Y. Roos, F. Vermeij, M. Wermer, H. B. Worp, P. Nederkoorn, N. Kruyt","doi":"10.1016/S1474-4422(24)00177-7","DOIUrl":"https://doi.org/10.1016/S1474-4422(24)00177-7","url":null,"abstract":"","PeriodicalId":22676,"journal":{"name":"The Lancet Neurology","volume":"3 12","pages":""},"PeriodicalIF":0.0,"publicationDate":"2024-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141055823","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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