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Calcium supplementation and the risk of dementia in the Perth Longitudinal Study of Aging Women: a post-hoc analysis of a randomised clinical trial for fracture prevention 珀斯老年妇女纵向研究中的补钙和痴呆风险:一项预防骨折的随机临床试验的事后分析
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101694
Negar Ghasemifard , Joshua R. Lewis , Simone Radavelli-Bagatini , Simon M. Laws , Blossom C.M. Stephan , Jonathan M. Hodgson , Kun Zhu , Richard L. Prince , Marc Sim

Background

Concerns have been raised around whether calcium supplements increase dementia risk. This post-hoc analysis of a five-year double-blind, placebo-controlled randomised trial of calcium supplements for primary fracture prevention evaluated the long-term risk for dementia in older women, randomised to either calcium supplements or placebo.

Methods

1460 community-dwelling dementia-free Australian women (≥70 years) were randomised to 1200 mg/day calcium carbonate (n = 730) or placebo (n = 730) for five years and were observed for an additional 9.5 years afterwards. Over 14.5 years, all-cause dementia events (comprising dementia-related hospitalisations and/or deaths) were identified from linked health records. The influence of calcium supplementation on dementia outcomes were examined using Kaplan–Meier survival curves and Cox regression under intention-to-treat (ITT) and per-protocol (PP, ≥80% tablet compliance, n = 830; 50.6% calcium supplements) criteria.

Findings

Mean baseline age was 75.1 ± 2.7 years. Dementia events were recorded in 269 women (18.4%), comprising 243 hospitalisations (16.6%) or 114 deaths (7.8%). No differences in the cumulative dementia-free survival rates were observed between groups in ITT and PP analyses. Compared to placebo, calcium supplements did not increase risk of dementia-related events (unadjusted ITT hazard ratio [HR] 0.90, 95% confidence interval (CI) 0.71–1.15), hospitalisations (HR 0.89, 95% CI 0.69–1.15) or deaths (HR 0.78, 95% CI 0.54–1.13). Similar results were observed in PP analyses.

Interpretation

Calcium supplementation for five years did not increase the risk of all-cause dementia events over 14.5 years in community-dwelling older women. Findings do not support concerns that calcium supplementation increases long-term risk of dementia.

Funding

National Health and Medical Research Council of Australia.
人们对钙补充剂是否会增加患痴呆症的风险表示担忧。这是一项为期5年的双盲、安慰剂对照的随机试验,通过钙补充剂预防初级骨折,评估老年妇女患痴呆的长期风险,随机分为钙补充剂组和安慰剂组。方法1460名社区无痴呆的澳大利亚女性(≥70岁)被随机分配到1200mg /天碳酸钙组(n = 730)或安慰剂组(n = 730),持续5年,之后再观察9.5年。在14.5年以上的时间里,从相关的健康记录中确定了全因痴呆事件(包括与痴呆相关的住院和/或死亡)。在意向治疗(ITT)和按方案(PP,≥80%服药依从性,n = 830;补钙50.6%)标准下,采用Kaplan-Meier生存曲线和Cox回归检验补钙对痴呆结局的影响。平均基线年龄为75.1±2.7岁。269名妇女(18.4%)发生痴呆,其中243人住院(16.6%)或114人死亡(7.8%)。在ITT和PP分析中,两组之间的累积无痴呆生存率没有差异。与安慰剂相比,钙补充剂不会增加痴呆相关事件的风险(未调整的ITT风险比[HR] 0.90, 95%可信区间(CI) 0.71-1.15)、住院(HR 0.89, 95% CI 0.69-1.15)或死亡(HR 0.78, 95% CI 0.54-1.13)。在PP分析中也观察到类似的结果。解释:在14.5岁以上的社区老年妇女中,补钙5年没有增加全因痴呆事件的风险。研究结果并不支持补钙会增加痴呆症长期风险的担忧。澳大利亚国家卫生和医学研究委员会。
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引用次数: 0
Trends of lipid-lowering drug utilization, treatment intensity and LDL-C target attainment in adults with diabetes and non-dialysis chronic kidney disease in Hong Kong 香港成人糖尿病及非透析慢性肾病患者的降脂药物使用趋势、治疗强度及LDL-C达标情况
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101696
Yanting Huang , Aimin Yang , Mai Shi , Jiazhou Yu , Hongjiang Wu , Juliana N.M. Lui , Alice P.S. Kong , Ronald C.W. Ma , Andrea O.Y. Luk , Calvin Ke , Juliana C.N. Chan , Elaine Chow

Background

With evolving treatment targets, concerns over renal safety for some statins and new lipid-lowering drugs (LLDs), we aimed to evaluate the trends of statins and non-statin LLDs [ezetimibe, and proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i)] utilization in individuals with diabetes and non-dialysis chronic kidney disease (CKD) in Hong Kong.

Methods

We conducted a retrospective cohort study of 332,975 Chinese individuals with diabetes and non-dialysis CKD using data from Hong Kong Hospital Authority in 2002–2019. We analyzed the annual average dosage, treatment intensity (low-intensity: <30% Low density lipoprotein-cholesterol (LDL-C) reduction; moderate-intensity: 30%–49%; high-intensity: ≥50%) and attained LDL-C targets defined by annual average LDL-C value. We evaluated the age-sex standardized trends of statin and common non-statin LLD use for primary and secondary prevention across age, sex and CKD stages.

Findings

Statin-users increased from 17.6% in 2002 to 71.3% in 2019 with similar trends across age, sex and CKD stages G3–5 except for the 18–49 age group having the highest proportion of non-users of LLD (39%). By 2019, the usage of ezetimibe (1.19%) and PCSK9i (0.01%) remained low. Amongst statin-users, 27.2% received moderate-intensity therapy for primary prevention and 11.2% received high-intensity therapy for secondary prevention. In 2019, 33.3% of LLD-users achieved LDL-C < 1.8 mmol/L for primary prevention and 21.3% achieved LDL-C < 1.4 mmol/L for secondary prevention.

Interpretation

Despite the increasing use of statins, treatment gaps remain with respect to treatment intensity and LDL-C target attainment in diabetes and non-dialysis CKD calling for increased use of combination statin and ezetimibe or PCSK9i to close the treatment gaps.

Funding

Dr. Aimin Yang was supported by a CUHK Impact Research Fellowship Scheme.
背景:随着治疗靶点的不断变化,一些他汀类药物和新型降脂药物(LLDs)对肾脏安全性的担忧,我们旨在评估他汀类药物和非他汀类药物(依zetimibe和蛋白转化酶枯草菌素/克辛蛋白9型抑制剂(PCSK9i))在香港糖尿病和非透析慢性肾脏疾病(CKD)患者中的使用趋势。方法:采用香港医院管理局2002-2019年的数据,对332,975名中国糖尿病和非透析慢性肾病患者进行回顾性队列研究。我们分析了年平均剂量,治疗强度(低强度:30%低密度脂蛋白-胆固醇(LDL-C)降低;中等强度:30% - -49%;高强度:≥50%),达到年平均LDL-C值定义的LDL-C目标。我们评估了他汀类药物和非他汀类LLD在不同年龄、性别和CKD阶段用于一级和二级预防的年龄-性别标准化趋势。他汀类药物使用者从2002年的17.6%增加到2019年的71.3%,除18-49岁年龄组非LLD使用者比例最高(39%)外,不同年龄、性别和CKD阶段的趋势相似。到2019年,依折麦布(1.19%)和PCSK9i(0.01%)的使用率仍然较低。在他汀类药物使用者中,27.2%接受中等强度一级预防治疗,11.2%接受高强度二级预防治疗。2019年,33.3%的低密度脂蛋白使用者一级预防LDL-C达到1.8 mmol/L,二级预防LDL-C达到1.4 mmol/L。解释:尽管他汀类药物的使用越来越多,但在糖尿病和非透析性慢性肾病的治疗强度和LDL-C目标实现方面,治疗差距仍然存在,需要增加他汀类药物和依泽可布或PCSK9i的联合使用,以缩小治疗差距。杨爱民获中大影响力研究奖学金资助。
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引用次数: 0
‘Playing to extinction’: the commercial determinants of gambling-related harm, suicidality and suicide “玩到灭绝”:赌博相关伤害、自杀和自杀的商业决定因素
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101685
Angela Rintoul , Suzanne McLaren , Kerrie Shandley , Britt Klein
This paper presents a model of the commercial determinants of health in the context of gambling-related harm, suicidality and suicide. It outlines the ways the gambling ecosystem undermines suicide prevention efforts by driving harmful engagement with gambling. Using the dominant, orthodox discourse of ‘responsible gambling’, the ecosystem relies on the effects of addiction to underpin, sustain, and grow its power. Attempts to introduce effective interventions to prevent gambling-related harms are often blocked by the gambling ecosystem actors, using an evidence base that is biased by its focus on individual level causation and the attendant ‘responsible gambling’ responses. This emphasis on individual responsibility diverts attention from the practices of the industry, generates stigma and shame for those harmed, downplays serious harms caused by gambling, and contributes to the suicide toll. As most gambling activity is unrecorded, and systems for monitoring harms are underdeveloped, the true extent of these consequences have been largely invisible. This makes it more difficult to hold governments to account to regulate and prevent gambling-related harms, including suicidality and suicide. With growing evidence of harms linked to gambling, including suicide and increasing public concern, we present measures that could be adopted to disrupt these determinants and improve accountability to prevent harms and save lives.
本文提出了在赌博相关伤害、自杀和自杀的背景下健康的商业决定因素的模型。它概述了赌博生态系统通过推动对赌博的有害参与来破坏自杀预防工作的方式。使用主流的、正统的“负责任的赌博”话语,这个生态系统依赖于成瘾的影响来巩固、维持和发展它的力量。引入有效干预措施以防止赌博相关危害的尝试往往受到赌博生态系统参与者的阻碍,他们使用的证据基础因其关注个人层面的因果关系和随之而来的“负责任的赌博”反应而存在偏见。这种对个人责任的强调转移了对该行业实践的关注,对那些受到伤害的人产生了耻辱和耻辱,淡化了赌博造成的严重危害,并导致了自杀人数的增加。由于大多数赌博活动未被记录,监测危害的系统也不发达,这些后果的真实程度在很大程度上是不可见的。这使得让政府负责监管和预防赌博相关危害(包括自杀和自杀)变得更加困难。随着越来越多的证据表明与赌博有关的危害,包括自杀和越来越多的公众关注,我们提出了可以采取的措施来破坏这些决定因素,并改善问责制,以防止伤害和拯救生命。
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引用次数: 0
Sociodemographic heterogeneity in the association between social isolation and all-cause mortality among Japanese older adults: JAGES longitudinal panel study 日本老年人社会孤立与全因死亡率之间的社会人口异质性:JAGES纵向面板研究
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101691
Frances Rom Lunar , Naoki Kondo , Yukiko Honda , Atsushi Nakagomi , Toshiaki Komura , Kosuke Inoue , Koichiro Shiba

Background

Social isolation has been linked to higher mortality; however, it remains unknown how this association varies across individuals and social groups.

Methods

We used a nationwide cohort study of ∼20,000 older adults with a 9·4-year follow-up period (Japan Gerontological Evaluation Study, 2013–2022), adjusting for 60 pre-baseline covariates. We also used a national insurance database to ascertain 4299 all-cause deaths. Using a causal machine-learning method, we estimated the heterogeneous association between social isolation and mortality.

Findings

Social isolation was more prevalent among those with lower education and income and associated on average with 69·5-day shorter survival time (restricted mean survival time [RMST] difference; 95% CI: −111, −28·4). There was evidence of heterogeneity where social isolation was associated with even shorter survival days in some subgroups (e.g., −205 days among the bottom quintile of the estimated RMST differences [95% CI: −321, −87·8]). These subgroups tended to be older, men, and have lower education. The adverse association of social isolation and mortality was particularly stronger when lower education was combined with higher income, especially among women. Individuals with lower levels of education accounted for a larger share of deaths attributable to social isolation (58·5% of excess deaths).

Interpretation

Social isolation may be more harmful among those from socially disadvantaged backgrounds, and a combination of some characteristics can synergistically amplify its effects on mortality. Proper population-level interventions informed with the evidence of effect heterogeneity might not only improve health on average but also mitigate existing health disparities.

Funding

Japan Society for the Promotion of Science, Health Labour Sciences Research Grants, Research Funding for Longevity Sciences from the National Center for Geriatrics and Gerontology, Research Institute of Science and Technology from the Japan Science and Technology, Japan Health Promotion & Fitness Foundation, Department of Active Ageing, Niigata University Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University Priority Research Areas Grant and National Research Institute for Earth Science and Disaster Resilience.
社会孤立与较高的死亡率有关;然而,这种关联在个体和社会群体之间的差异尚不清楚。方法:我们采用了一项全国队列研究,对2万名老年人进行了9.4年的随访(日本老年学评估研究,2013-2022),调整了60个基线前协变量。我们还利用国家保险数据库确定了4299例全因死亡。使用因果机器学习方法,我们估计了社会孤立与死亡率之间的异质性关联。社会隔离在受教育程度和收入较低的人群中更为普遍,平均生存时间缩短69.5天(限制平均生存时间[RMST]差异;95% CI: - 111, - 28.4)。有异质性的证据表明,在一些亚组中,社会隔离与更短的生存时间相关(例如,在RMST估计差异的最低五分之一中,- 205天[95% CI: - 321, - 87·8])。这些亚群体往往是年龄较大、受教育程度较低的男性。在低教育与高收入并存的情况下,特别是在妇女中,社会孤立与死亡率之间的不利联系尤为明显。受教育程度较低的人在归因于社会孤立的死亡中所占比例较大(占额外死亡人数的58.5%)。社会孤立可能对那些来自社会弱势背景的人更有害,一些特征的结合可以协同放大其对死亡率的影响。适当的人口水平干预措施,在了解效果异质性证据的情况下,不仅可以改善平均健康状况,还可以减轻现有的健康差距。日本科学促进会、卫生劳动科学研究基金、国家老年医学和老年医学中心长寿科学研究基金、日本科学技术研究所、日本健康促进和健身基金会、新泻大学医学和牙科科学研究生院积极老龄化部、东京医科和牙科大学优先研究领域资助和国家地球科学和灾害恢复研究所。
{"title":"Sociodemographic heterogeneity in the association between social isolation and all-cause mortality among Japanese older adults: JAGES longitudinal panel study","authors":"Frances Rom Lunar ,&nbsp;Naoki Kondo ,&nbsp;Yukiko Honda ,&nbsp;Atsushi Nakagomi ,&nbsp;Toshiaki Komura ,&nbsp;Kosuke Inoue ,&nbsp;Koichiro Shiba","doi":"10.1016/j.lanwpc.2025.101691","DOIUrl":"10.1016/j.lanwpc.2025.101691","url":null,"abstract":"<div><h3>Background</h3><div>Social isolation has been linked to higher mortality; however, it remains unknown how this association varies across individuals and social groups.</div></div><div><h3>Methods</h3><div>We used a nationwide cohort study of ∼20,000 older adults with a 9·4-year follow-up period (Japan Gerontological Evaluation Study, 2013–2022), adjusting for 60 pre-baseline covariates. We also used a national insurance database to ascertain 4299 all-cause deaths. Using a causal machine-learning method, we estimated the heterogeneous association between social isolation and mortality.</div></div><div><h3>Findings</h3><div>Social isolation was more prevalent among those with lower education and income and associated on average with 69·5-day shorter survival time (restricted mean survival time [RMST] difference; 95% CI: −111, −28·4). There was evidence of heterogeneity where social isolation was associated with even shorter survival days in some subgroups (e.g., −205 days among the bottom quintile of the estimated RMST differences [95% CI: −321, −87·8]). These subgroups tended to be older, men, and have lower education. The adverse association of social isolation and mortality was particularly stronger when lower education was combined with higher income, especially among women. Individuals with lower levels of education accounted for a larger share of deaths attributable to social isolation (58·5% of excess deaths).</div></div><div><h3>Interpretation</h3><div>Social isolation may be more harmful among those from socially disadvantaged backgrounds, and a combination of some characteristics can synergistically amplify its effects on mortality. Proper population-level interventions informed with the evidence of effect heterogeneity might not only improve health on average but also mitigate existing health disparities.</div></div><div><h3>Funding</h3><div><span>Japan Society for the Promotion of Science</span>, <span>Health Labour Sciences Research Grants</span>, <span>Research Funding for Longevity Sciences from the National Center for Geriatrics and Gerontology</span>, Research Institute of Science and Technology from the <span>Japan Science and Technology</span>, <span>Japan Health Promotion &amp; Fitness Foundation</span>, <span>Department of Active Ageing</span>, <span>Niigata University Graduate School of Medical and Dental Sciences</span>, Tokyo Medical and Dental University Priority Research Areas Grant and National Research Institute for Earth Science and Disaster Resilience.</div></div>","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"63 ","pages":"Article 101691"},"PeriodicalIF":8.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222434","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The World Health Organization (WHO) Enhanced Gonococcal Antimicrobial Surveillance Programme (EGASP) reports continuously high levels of ceftriaxone resistance across Viet Nam, 2024 世界卫生组织(世卫组织)强化淋球菌抗微生物监测规划(EGASP)报告称,2024年越南全国持续出现头孢曲松高水平耐药性
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101709
Pham Thi Lan , Thuy Thi Phan Nguyen , Vu Tuan Anh , Daniel Golparian , Nguyen Thi Thuy Van , Ismael Maatouk , Magnus Unemo
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引用次数: 0
Chikungunya: a growing public health concern in the Western Pacific region 基孔肯雅热:西太平洋区域日益严重的公共卫生问题
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101733
The Lancet Regional Health – Western Pacific
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引用次数: 0
Improving support for people with mental health problems in China: a cluster randomised controlled trial of culturally adapted Mental Health First Aid training 改善对中国精神健康问题患者的支持:一项文化适应精神健康急救培训的随机对照试验
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101698
Nicola Reavley , Amy J. Morgan , Anthony F. Jorm , Betty Kitchener , Yan Wang , Shurong Lu , Wenjing Li , Claire Kelly , Brian Oldenburg , Min Zhao , Yanling He

Background

Culturally appropriate interventions that teach members of the public to provide early help towards a person developing a mental health problem or in a mental health crisis may improve access to services, social support, and mental health outcomes. This is the first study to evaluate the effectiveness of culturally adapted Mental Health First Aid (MHFA) Training for China.

Methods

A two-arm wait-list pilot cluster randomised controlled trial (cRCT) was conducted in 3 settings in Shanghai (health services, workplaces and community settings). Intervention settings were paired according to type and one of each pair was randomly allocated to the intervention (MHFA Training for China) or the wait-list control group, with a 1:1 allocation. Participants were invited by the trial coordinators in each setting. They were asked to complete questionnaires at baseline (T1) and 1 month (T2) and 7 months after training (T3). Control group participants were asked to complete questionnaires at corresponding times. The primary outcome was participant intended actions (recommended or not recommended) towards a person experiencing a mental health problem or in a mental health crisis. Secondary outcomes included recognition of depression in a vignette; beliefs about the helpfulness of health professionals and interventions; helping actions; confidence in providing mental health first aid; and stigmatising attitudes.

Findings

Between April and May 2024, 6 clusters were recruited and randomised, with 3 in each of the intervention and control arms. Following exclusion of participants who did not provide data, 146 participants were included at baseline: 67 in the intervention group and 79 in the control group. For the primary outcome (recommended actions subscale), the intervention group showed a significantly larger improvement than the control group at T2 (8.19 [95% CI 4.05–12.34]; p < 0.001) and T3 (3.08 [95% CI −1.02 to 7.18]; p = 0.034). Differences in changes in non-recommended actions were non-significant. At T2, significant differences favouring the intervention group were observed in confidence to provide support, perceiving the person as dangerous or unpredictable and in recognition of depression in a vignette. There were no significant differences in secondary outcomes at T3.

Interpretation

Delivering culturally adapted MHFA Training for China more widely could improve support for people experiencing mental health problems in the community.

Funding

This trial was supported the National Health and Medical Research Council under a Global Alliance for Chronic Diseases grant (GNT1142395).
背景:在文化上适当的干预措施,教导公众对出现精神健康问题或处于精神健康危机中的人提供早期帮助,可能会改善获得服务、社会支持和精神健康结果的机会。这是第一个评估中国文化适应性心理健康急救(MHFA)培训有效性的研究。方法在上海市卫生服务机构、工作场所和社区3个环境中进行两臂等待名单试验随机对照试验(cRCT)。将干预设置按类型进行配对,每对中随机分配1个干预组(MHFA中国培训组)或等候名单对照组,按1:1的比例分配。参与者是由试验协调员在每种情况下邀请的。在基线(T1)、训练后1个月(T2)和7个月(T3)完成问卷调查。对照组参与者被要求在相应的时间完成问卷调查。主要结果是参与者对经历精神健康问题或处于精神健康危机的人有意采取的行动(建议或不建议)。次要结局包括在小插曲中识别抑郁症;对卫生专业人员的帮助和干预措施的信念;帮助行为;对提供精神卫生急救的信心;以及污名化的态度。在2024年4月至5月期间,招募并随机分组了6组,干预组和对照组各3组。在排除了没有提供数据的参与者后,146名参与者在基线时被纳入:干预组67名,对照组79名。对于主要结局(推荐行动分量表),干预组在T2 (8.19 [95% CI 4.05-12.34]; p < 0.001)和T3 (3.08 [95% CI - 1.02至7.18];p = 0.034)时的改善显著大于对照组。非推荐行动的变化差异不显著。在T2时,观察到干预组在提供支持的信心,感知该人危险或不可预测以及在小插曲中识别抑郁症方面存在显著差异。T3时的次要结局无显著差异。在中国更广泛地开展与文化相适应的MHFA培训可以改善对社区中遇到精神健康问题的人的支持。该试验由国家卫生和医学研究委员会在全球慢性疾病联盟资助下(GNT1142395)支持。
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引用次数: 0
Community-based versus facility-based services to improve hepatitis C screening in Cambodia: a cluster randomized controlled trial (ANRS 12384 Cam-C study) 以社区为基础的服务与以设施为基础的服务改善柬埔寨丙型肝炎筛查:一项随机对照试验(ANRS 12384 Cam-C研究)
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101703
Dyna Khuon , Luis Sagaon-Teyssier , Sansothy Neth , Saly Saint , Laurence Meyer , Emilie Mosnier , Diana Molino , Chan Leakhena Phoeung , Chhingsrean Chhay , Kimeang Heang , Sovatha Mam , Jean-Charles Duclos-Vallée , Olivier Ségéral , Vonthanak Saphonn

Background

The estimated prevalence of hepatitis C virus (HCV) infection among adults aged over 45 years in Cambodia is approximately 5%. The present study aimed assessing the effectiveness of a novel community-based strategy comprising HCV rapid testing (RDT) and dried blood spot (DBS) collection performed by community health workers (CHWs) in outreach contexts.

Methods

ANRS 12384 Cam-C is a parallel arm cluster randomized controlled trial conducted in the Siem Reap and Kampong Cham provinces of Cambodia between April 2022 and September 2023. Four geographical areas in each province were randomized into two arms to compare HCV RDT and DBS collection provided in homes by community health workers (i.e., community-based strategy) with facility-based HCV RDT and whole blood collection provided by healthcare workers in health centers (i.e., facility-based strategy). The primary outcome was combined testing uptake, defined as the proportion of participants who were actually tested for HCV using RDT or RDT/RNA if positive out of all those who participated in the study. Mixed effects logistic models were used to estimate the effect of the community-based strategy. The study is registered on ClinicalTrials.gov (NCT03992313).

Findings

Among the 7692 participants who initially enrolled in the study, 5590 (72.7%) actually went on to have HCV RDT or HCV RDT/RNA screening (i.e., combined testing uptake). Combined testing uptake in the community-based (2990 participants) and facility-based (2600 participants) arms was 78.1% and 67.3%, respectively (p < 0.001). Positive HCV RDT was found for 57 (2.2%) including 39 (1.5%) with detectable HCV RNA among participants in the facility-based arm. In the community-based arm, 37 (1.2%) had positive HCV RDT including 32 (1.1%) with detectable HCV RNA. Treatment uptake concerned 36 participants (out of 39 with positive HCV RDT) and 30 (out of 32) in the facility-based and community-based arms, respectively. The odds of combined testing uptake in the community-based strategy were 2.18 (95% CI [1.28–3.73], p = 0.004) times higher than in the facility-based strategy.

Interpretation

Combined testing uptake (HCV RDT or HCV RDT/RNA) was higher for the community-based strategy than for the facility-based strategy. The involvement of community health workers improved first contact with HCV services and uptake. Integrating this trial's community-based screening strategy into the national Cambodian HCV program could improve its effectiveness as part of the country's broader goal of eliminating HCV by 2030.

Funding

This study was supported by the ANRS MIE (ANRS 12384).
柬埔寨45岁以上成年人中丙型肝炎病毒(HCV)感染的估计流行率约为5%。本研究旨在评估一种新型社区策略的有效性,该策略包括由社区卫生工作者(CHWs)在外展环境中执行的HCV快速检测(RDT)和干血斑(DBS)收集。方法sanrs 12384 Cam-C是一项平行臂群随机对照试验,于2022年4月至2023年9月在柬埔寨暹粒省和磅湛省进行。每个省的四个地理区域被随机分为两组,以比较社区卫生工作者在家中提供的HCV RDT和DBS采集(即基于社区的策略)与卫生中心卫生工作者提供的基于设施的HCV RDT和全血采集(即基于设施的策略)。主要结果是综合检测摄取,定义为在所有参与研究的参与者中,使用RDT或RDT/RNA进行HCV检测的参与者比例(如果RDT/RNA阳性)。混合效应logistic模型用于评估社区策略的效果。该研究已在ClinicalTrials.gov注册(NCT03992313)。在7692名最初参加研究的参与者中,5590名(72.7%)实际上继续进行了HCV RDT或HCV RDT/RNA筛查(即联合检测摄取)。以社区为基础(2990名参与者)和以医疗机构为基础(2600名参与者)两组的联合测试接受率分别为78.1%和67.3% (p < 0.001)。HCV RDT阳性57人(2.2%),其中39人(1.5%)HCV RNA可检测。在社区组中,37例(1.2%)HCV RDT阳性,其中32例(1.1%)HCV RNA可检测。治疗接受情况分别涉及36名参与者(39名HCV RDT阳性)和30名参与者(32名),分别来自设施组和社区组。以社区为基础的策略采用联合检测的几率是以设施为基础策略的2.18倍(95% CI [1.28-3.73], p = 0.004)。以社区为基础的策略比以设施为基础的策略的综合检测摄取(HCV RDT或HCV RDT/RNA)更高。社区卫生工作者的参与改善了初次接触丙型肝炎病毒的服务和吸收情况。将该试验的基于社区的筛查策略纳入柬埔寨全国丙肝病毒规划,可以提高其有效性,使其成为该国到2030年消除丙肝病毒这一更广泛目标的一部分。本研究由ANRS MIE (ANRS 12384)支持。
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引用次数: 0
Corrigendum to A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study Lancet Reg Health West Pac (2023) 38: 100846 一项比较自身抗体诊断方法在重症肌无力中的准确性的多中心、前瞻性、双盲研究的勘误表:SCREAM研究Lancet Reg Health West Pac (2023) 38: 100846
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101665
Zhiguo Li , Chao Zhang , Ting Chang , Xinghu Zhang , Huan Yang , Feng Gao , Jinzhou Feng , Hongbo Liu , Sheng Chen , Lihua Wang , Chunsheng Yang , Huining Li , Yuesong Pan , Jacqueline Palace , Fu-Dong Shi
{"title":"Corrigendum to A multicentre, prospective, double-blind study comparing the accuracy of autoantibody diagnostic assays in myasthenia gravis: the SCREAM study Lancet Reg Health West Pac (2023) 38: 100846","authors":"Zhiguo Li ,&nbsp;Chao Zhang ,&nbsp;Ting Chang ,&nbsp;Xinghu Zhang ,&nbsp;Huan Yang ,&nbsp;Feng Gao ,&nbsp;Jinzhou Feng ,&nbsp;Hongbo Liu ,&nbsp;Sheng Chen ,&nbsp;Lihua Wang ,&nbsp;Chunsheng Yang ,&nbsp;Huining Li ,&nbsp;Yuesong Pan ,&nbsp;Jacqueline Palace ,&nbsp;Fu-Dong Shi","doi":"10.1016/j.lanwpc.2025.101665","DOIUrl":"10.1016/j.lanwpc.2025.101665","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"63 ","pages":"Article 101665"},"PeriodicalIF":8.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145222433","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Risk of cancer associated with residential exposure to asbestos insulation: updated evidence 与住宅暴露于石棉绝缘材料相关的癌症风险:最新证据
IF 8.1 1区 医学 Q1 HEALTH CARE SCIENCES & SERVICES Pub Date : 2025-10-01 DOI: 10.1016/j.lanwpc.2025.101699
Hsei Di Law , Mark Clements , Nina Lazarevic , Kayla Smurthwaite , Susan Trevenar , Leah Newman , Elizabeth Chalker , Martyn D. Kirk , Rosemary J. Korda
{"title":"Risk of cancer associated with residential exposure to asbestos insulation: updated evidence","authors":"Hsei Di Law ,&nbsp;Mark Clements ,&nbsp;Nina Lazarevic ,&nbsp;Kayla Smurthwaite ,&nbsp;Susan Trevenar ,&nbsp;Leah Newman ,&nbsp;Elizabeth Chalker ,&nbsp;Martyn D. Kirk ,&nbsp;Rosemary J. Korda","doi":"10.1016/j.lanwpc.2025.101699","DOIUrl":"10.1016/j.lanwpc.2025.101699","url":null,"abstract":"","PeriodicalId":22792,"journal":{"name":"The Lancet Regional Health: Western Pacific","volume":"63 ","pages":"Article 101699"},"PeriodicalIF":8.1,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145269493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":1,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
期刊
The Lancet Regional Health: Western Pacific
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