Pub Date : 2024-05-02DOI: 10.2967/jnumed.123.267321
Robert Seifert, Tugce Telli, Constantin Lapa, Mélanie Desaulniers, Turkay Hekimsoy, Wolfgang A. Weber, Christian Pfob, Boris Hadaschik, Martin Bögemann, Michael Schäfers, Ken Herrmann, Kambiz Rahbar, Matthias Eiber, Wolfgang P. Fendler
Visual Abstract
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{"title":"Safety and Efficacy of Extended Therapy with [177Lu]Lu-PSMA: A German Multicenter Study","authors":"Robert Seifert, Tugce Telli, Constantin Lapa, Mélanie Desaulniers, Turkay Hekimsoy, Wolfgang A. Weber, Christian Pfob, Boris Hadaschik, Martin Bögemann, Michael Schäfers, Ken Herrmann, Kambiz Rahbar, Matthias Eiber, Wolfgang P. Fendler","doi":"10.2967/jnumed.123.267321","DOIUrl":"https://doi.org/10.2967/jnumed.123.267321","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267321absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140821071","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-05-02DOI: 10.2967/jnumed.123.267281
Brad Kline, Surekha Yadav, Youngho Seo, Robin Cumming Ippisch, Jessa Castillo, Rahul R. Aggarwal, Robin Kate Kelley, Spencer C. Behr, Robert R. Flavell, Courtney Lawhn-Heath, Michelle Melisko, Hope S. Rugo, Victoria Wang, Sue S. Yom, Patrick Ha, Fei Jiang, Thomas A. Hope
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{"title":"68Ga-FAP-2286 PET of Solid Tumors: Biodistribution, Dosimetry, and Comparison with 18F-FDG","authors":"Brad Kline, Surekha Yadav, Youngho Seo, Robin Cumming Ippisch, Jessa Castillo, Rahul R. Aggarwal, Robin Kate Kelley, Spencer C. Behr, Robert R. Flavell, Courtney Lawhn-Heath, Michelle Melisko, Hope S. Rugo, Victoria Wang, Sue S. Yom, Patrick Ha, Fei Jiang, Thomas A. Hope","doi":"10.2967/jnumed.123.267281","DOIUrl":"https://doi.org/10.2967/jnumed.123.267281","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267281absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-05-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140820967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.2967/jnumed.123.266687
Jurij Rosen, Jan-Michael Werner, Garry S. Ceccon, Elena K. Rosen, Michael M. Wollring, Isabelle Stetter, Philipp Lohmann, Felix M. Mottaghy, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks
Visual Abstract
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{"title":"MRI and 18F-FET PET for Multimodal Treatment Monitoring in Patients with Brain Metastases: A Cost-Effectiveness Analysis","authors":"Jurij Rosen, Jan-Michael Werner, Garry S. Ceccon, Elena K. Rosen, Michael M. Wollring, Isabelle Stetter, Philipp Lohmann, Felix M. Mottaghy, Gereon R. Fink, Karl-Josef Langen, Norbert Galldiks","doi":"10.2967/jnumed.123.266687","DOIUrl":"https://doi.org/10.2967/jnumed.123.266687","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266687absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649096","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.2967/jnumed.123.266659
Wenhui Zhou, Sumit Halder, Sanna Herwald, Michael Ghijsen, Gowhar Shafi, Mohan Uttarwar, Eric Rosen, Benjamin Franc, Sirish Kishore
Visual Abstract
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{"title":"Frequent Amplification and Overexpression of PSMA in Basallike Breast Cancer from Analysis of The Cancer Genome Atlas","authors":"Wenhui Zhou, Sumit Halder, Sanna Herwald, Michael Ghijsen, Gowhar Shafi, Mohan Uttarwar, Eric Rosen, Benjamin Franc, Sirish Kishore","doi":"10.2967/jnumed.123.266659","DOIUrl":"https://doi.org/10.2967/jnumed.123.266659","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266659absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.2967/jnumed.123.267004
John Nikitas, Ethan Lam, Kiara Adame Booker, Wolfgang P. Fendler, Matthias Eiber, Boris Hadaschik, Ken Herrmann, Nader Hirmas, Helena Lanzafame, Martin Stuschke, Johannes Czernin, Michael L. Steinberg, Nicholas G. Nickols, Amar U. Kishan, Jeremie Calais
Visual Abstract
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{"title":"Randomized Trial of Prostate-Specific Membrane Antigen PET/CT Before Definitive Radiotherapy for Unfavorable Intermediate- and High-Risk Prostate Cancer (PSMA-dRT Trial)","authors":"John Nikitas, Ethan Lam, Kiara Adame Booker, Wolfgang P. Fendler, Matthias Eiber, Boris Hadaschik, Ken Herrmann, Nader Hirmas, Helena Lanzafame, Martin Stuschke, Johannes Czernin, Michael L. Steinberg, Nicholas G. Nickols, Amar U. Kishan, Jeremie Calais","doi":"10.2967/jnumed.123.267004","DOIUrl":"https://doi.org/10.2967/jnumed.123.267004","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267004absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648851","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.2967/jnumed.123.267017
Heying Duan, Hong Song, Guido A. Davidzon, Farshad Moradi, Tie Liang, Andreas Loening, Shreyas Vasanawala, Andrei Iagaru
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{"title":"Prospective Comparison of 68Ga-NeoB and 68Ga-PSMA-R2 PET/MRI in Patients with Biochemically Recurrent Prostate Cancer","authors":"Heying Duan, Hong Song, Guido A. Davidzon, Farshad Moradi, Tie Liang, Andreas Loening, Shreyas Vasanawala, Andrei Iagaru","doi":"10.2967/jnumed.123.267017","DOIUrl":"https://doi.org/10.2967/jnumed.123.267017","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267017absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.2967/jnumed.124.267521
Clemens Mingels, Benjamin A. Spencer, Hande Nalbant, Negar Omidvari, Mehrad Rokni, Axel Rominger, Fatma Sen, Simon R. Cherry, Ramsey D. Badawi, Yasser G. Abdelhafez, Lorenzo Nardo
Visual Abstract
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{"title":"Dose Reduction in Pediatric Oncology Patients with Delayed Total-Body [18F]FDG PET/CT","authors":"Clemens Mingels, Benjamin A. Spencer, Hande Nalbant, Negar Omidvari, Mehrad Rokni, Axel Rominger, Fatma Sen, Simon R. Cherry, Ramsey D. Badawi, Yasser G. Abdelhafez, Lorenzo Nardo","doi":"10.2967/jnumed.124.267521","DOIUrl":"https://doi.org/10.2967/jnumed.124.267521","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.124.267521absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140648965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-25DOI: 10.2967/jnumed.123.266463
Brian J. Burkett, Derek R. Johnson, Val J. Lowe
Antiamyloid therapies for Alzheimer disease recently entered clinical practice, making imaging biomarkers for Alzheimer disease even more relevant to guiding patient management. Amyloid and tau PET are valuable tools that can provide objective evidence of Alzheimer pathophysiology in living patients and will increasingly be used to complement 18F-FDG PET in the diagnostic evaluation of cognitive impairment and dementia. Parkinsonian syndromes, also common causes of dementia, can likewise be evaluated with a PET imaging biomarker,18F-DOPA, allowing in vivo assessment of the presynaptic dopaminergic neurons. Understanding the role of these PET biomarkers will help the nuclear medicine physician contribute to the appropriate diagnosis and management of patients with cognitive impairment and dementia. To successfully evaluate brain PET examinations for neurodegenerative diseases, knowledge of the necessary protocol details for obtaining a reliable imaging study, inherent limitations for each PET radiopharmaceutical, and pitfalls in image interpretation is critical. This review will focus on underlying concepts for interpreting PET examinations, important procedural details, and guidance for avoiding potential interpretive pitfalls for amyloid, tau, and dopaminergic PET examinations.
治疗阿尔茨海默病的抗淀粉样蛋白疗法最近已进入临床实践，这使得阿尔茨海默病的成像生物标志物在指导患者管理方面变得更加重要。淀粉样蛋白和 tau PET 是非常有价值的工具，可以为在世患者提供阿尔茨海默病病理生理学的客观证据，在认知障碍和痴呆的诊断评估中将越来越多地用于补充 18F-FDG PET。帕金森综合征也是痴呆症的常见病因，同样可以用 PET 成像生物标记物 18F-DOPA 进行评估，从而对突触前多巴胺能神经元进行体内评估。了解这些 PET 生物标记物的作用将有助于核医学医生对认知障碍和痴呆症患者进行适当的诊断和管理。要成功评估神经退行性疾病的脑 PET 检查，了解获得可靠成像研究的必要方案细节、每种 PET 放射性药物的固有局限性以及图像解读中的误区至关重要。本综述将重点介绍解读 PET 检查的基本概念、重要的程序细节以及避免淀粉样蛋白、tau 和多巴胺能 PET 检查潜在解读误区的指南。
{"title":"Evaluation of Neurodegenerative Disorders with Amyloid-β, Tau, and Dopaminergic PET Imaging: Interpretation Pitfalls","authors":"Brian J. Burkett, Derek R. Johnson, Val J. Lowe","doi":"10.2967/jnumed.123.266463","DOIUrl":"https://doi.org/10.2967/jnumed.123.266463","url":null,"abstract":"<p>Antiamyloid therapies for Alzheimer disease recently entered clinical practice, making imaging biomarkers for Alzheimer disease even more relevant to guiding patient management. Amyloid and tau PET are valuable tools that can provide objective evidence of Alzheimer pathophysiology in living patients and will increasingly be used to complement <sup>18</sup>F-FDG PET in the diagnostic evaluation of cognitive impairment and dementia. Parkinsonian syndromes, also common causes of dementia, can likewise be evaluated with a PET imaging biomarker,<sup>18</sup>F-DOPA, allowing in vivo assessment of the presynaptic dopaminergic neurons. Understanding the role of these PET biomarkers will help the nuclear medicine physician contribute to the appropriate diagnosis and management of patients with cognitive impairment and dementia. To successfully evaluate brain PET examinations for neurodegenerative diseases, knowledge of the necessary protocol details for obtaining a reliable imaging study, inherent limitations for each PET radiopharmaceutical, and pitfalls in image interpretation is critical. This review will focus on underlying concepts for interpreting PET examinations, important procedural details, and guidance for avoiding potential interpretive pitfalls for amyloid, tau, and dopaminergic PET examinations.</p>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140649013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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