Pub Date : 2024-04-18DOI: 10.2967/jnumed.123.266619
Alexandros Moraitis, Walter Jentzen, Pedro Fragoso Costa, David Kersting, Stephan Himmen, Marta Coelho, Marian Meckel, Cees J.A. van Echteld, Wolfgang P. Fendler, Ken Herrmann, Miriam Sraieb
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{"title":"Safety and Efficacy of Para-Aminohippurate Coinfusion for Renal Protection During Peptide Receptor Radiotherapy in Patients with Neuroendocrine Tumors","authors":"Alexandros Moraitis, Walter Jentzen, Pedro Fragoso Costa, David Kersting, Stephan Himmen, Marta Coelho, Marian Meckel, Cees J.A. van Echteld, Wolfgang P. Fendler, Ken Herrmann, Miriam Sraieb","doi":"10.2967/jnumed.123.266619","DOIUrl":"https://doi.org/10.2967/jnumed.123.266619","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266619absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.2967/jnumed.123.267260
Marinus J. Hagens, Pim J. van Leeuwen, Maurits Wondergem, Thierry N. Boellaard, Francesco Sanguedolce, Daniela E. Oprea-Lager, Axel Bex, André N. Vis, Henk G. van der Poel, Laura S. Mertens, in collaboration with the EAU Section of Urological Imaging
Visual Abstract
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{"title":"A Systematic Review on the Diagnostic Value of Fibroblast Activation Protein Inhibitor PET/CT in Genitourinary Cancers","authors":"Marinus J. Hagens, Pim J. van Leeuwen, Maurits Wondergem, Thierry N. Boellaard, Francesco Sanguedolce, Daniela E. Oprea-Lager, Axel Bex, André N. Vis, Henk G. van der Poel, Laura S. Mertens, in collaboration with the EAU Section of Urological Imaging","doi":"10.2967/jnumed.123.267260","DOIUrl":"https://doi.org/10.2967/jnumed.123.267260","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267260absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.2967/jnumed.123.267234
Andrei Gafita, Loic Djaileb, Isabel Rauscher, Wolfgang P. Fendler, Boris Hadaschik, Steven P. Rowe, Ken Herrmann, Lilja B. Solnes, Jeremie Calais, Matthew B. Rettig, Manuel Weber, Andrea Farolfi, Matthias R. Benz, Matthias Eiber
Visual Abstract
视觉摘要
{"title":"RECIP 1.0 Predicts Progression-Free Survival After [177Lu]Lu-PSMA Radiopharmaceutical Therapy in Patients with Metastatic Castration-Resistant Prostate Cancer","authors":"Andrei Gafita, Loic Djaileb, Isabel Rauscher, Wolfgang P. Fendler, Boris Hadaschik, Steven P. Rowe, Ken Herrmann, Lilja B. Solnes, Jeremie Calais, Matthew B. Rettig, Manuel Weber, Andrea Farolfi, Matthias R. Benz, Matthias Eiber","doi":"10.2967/jnumed.123.267234","DOIUrl":"https://doi.org/10.2967/jnumed.123.267234","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267234absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620534","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-18DOI: 10.2967/jnumed.123.266925
Rebecca Moser, Sophie Pfeiffer, Lisena Cala, Evelyn Klein, Marion Kiechle, Sophie T. Behzadi, Eva Fallenberg, Stephanie E. Combs, Wolfgang Weber, Kai J. Borm
Visual Abstract
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{"title":"Detecting Metastatic Patterns of Oligometastatic Breast Cancer: A Comparative Analysis of 18F-FDG PET/CT and Conventional CT Imaging","authors":"Rebecca Moser, Sophie Pfeiffer, Lisena Cala, Evelyn Klein, Marion Kiechle, Sophie T. Behzadi, Eva Fallenberg, Stephanie E. Combs, Wolfgang Weber, Kai J. Borm","doi":"10.2967/jnumed.123.266925","DOIUrl":"https://doi.org/10.2967/jnumed.123.266925","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266925absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140620243","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.2967/jnumed.123.267006
Paul Viscuse, Michael Devitt, Robert Dreicer
Most men with newly appreciated metastatic prostate cancer are optimally treated with a backbone consisting of androgen receptor–directed therapy with or without taxane chemotherapy. Despite improvements in disease outcomes, prostate cancer remains an extremely heterogeneous disease with variable mechanisms of therapeutic resistance. As a result, it remains a leading cause of cancer-related death in men. Radiopharmaceutical therapy has emerged as an alternative, non–androgen receptor–directed treatment modality for metastatic castration-resistant prostate cancer that impacts patient survival and represents a potentially more personalized approach. In this review, we aim to outline the current treatment landscape for metastatic prostate cancer with a focus on radiopharmaceutical therapy, specifically 177Lu-PSMA-617. In addition, we illustrate various clinical challenges with 177Lu-PSMA-617 treatment to date and explore investigative efforts to leverage radiopharmaceutical therapies as part of combination regimens or earlier in the treatment algorithm to further improve patient outcomes. Finally, we introduce ongoing studies of alternative radiopharmaceutical therapies in metastatic prostate cancer that may be incorporated into the treatment algorithm pending further study.
{"title":"Clinical Management of Advanced Prostate Cancer: Where Does Radiopharmaceutical Therapy Fit in the Treatment Algorithm?","authors":"Paul Viscuse, Michael Devitt, Robert Dreicer","doi":"10.2967/jnumed.123.267006","DOIUrl":"https://doi.org/10.2967/jnumed.123.267006","url":null,"abstract":"<p>Most men with newly appreciated metastatic prostate cancer are optimally treated with a backbone consisting of androgen receptor–directed therapy with or without taxane chemotherapy. Despite improvements in disease outcomes, prostate cancer remains an extremely heterogeneous disease with variable mechanisms of therapeutic resistance. As a result, it remains a leading cause of cancer-related death in men. Radiopharmaceutical therapy has emerged as an alternative, non–androgen receptor–directed treatment modality for metastatic castration-resistant prostate cancer that impacts patient survival and represents a potentially more personalized approach. In this review, we aim to outline the current treatment landscape for metastatic prostate cancer with a focus on radiopharmaceutical therapy, specifically <sup>177</sup>Lu-PSMA-617. In addition, we illustrate various clinical challenges with <sup>177</sup>Lu-PSMA-617 treatment to date and explore investigative efforts to leverage radiopharmaceutical therapies as part of combination regimens or earlier in the treatment algorithm to further improve patient outcomes. Finally, we introduce ongoing studies of alternative radiopharmaceutical therapies in metastatic prostate cancer that may be incorporated into the treatment algorithm pending further study.</p>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547717","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.2967/jnumed.123.267103
Manuel Röhrich, Johanna Daum, Ewgenija Gutjahr, Anna-Maria Spektor, Frederik M. Glatting, Yasemin Aylin Sahin, Hans Georg Buchholz, Jorge Hoppner, Cathrin Schroeter, Eleni Mavriopoulou, Kai Schlamp, Matthias Grott, Florian Eichhorn, Claus Peter Heußel, Hans Ulrich Kauczor, Michael Kreuter, Frederik Giesel, Mathias Schreckenberger, Hauke Winter, Uwe Haberkorn
Visual Abstract
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{"title":"Diagnostic Potential of Supplemental Static and Dynamic 68Ga-FAPI-46 PET for Primary 18F-FDG–Negative Pulmonary Lesions","authors":"Manuel Röhrich, Johanna Daum, Ewgenija Gutjahr, Anna-Maria Spektor, Frederik M. Glatting, Yasemin Aylin Sahin, Hans Georg Buchholz, Jorge Hoppner, Cathrin Schroeter, Eleni Mavriopoulou, Kai Schlamp, Matthias Grott, Florian Eichhorn, Claus Peter Heußel, Hans Ulrich Kauczor, Michael Kreuter, Frederik Giesel, Mathias Schreckenberger, Hauke Winter, Uwe Haberkorn","doi":"10.2967/jnumed.123.267103","DOIUrl":"https://doi.org/10.2967/jnumed.123.267103","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.267103absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547629","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.2967/jnumed.123.266686
Qi Wu, Fengyun Gu, Liam D. O’Suilleabhain, Hasan Sari, Song Xue, Kuangyu Shi, Axel Rominger, Finbarr O’Sullivan
Visual Abstract
视觉摘要
{"title":"Mapping 18F-FDG Kinetics Together with Patient-Specific Bootstrap Assessment of Uncertainties: An Illustration with Data from a PET/CT Scanner with a Long Axial Field of View","authors":"Qi Wu, Fengyun Gu, Liam D. O’Suilleabhain, Hasan Sari, Song Xue, Kuangyu Shi, Axel Rominger, Finbarr O’Sullivan","doi":"10.2967/jnumed.123.266686","DOIUrl":"https://doi.org/10.2967/jnumed.123.266686","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266686absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547622","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Pub Date : 2024-04-11DOI: 10.2967/jnumed.123.266860
John L. O’Donnell, Anil Kumar Soda, Hao Jiang, Scott A. Norris, Baijayanta Maiti, Morvarid Karimi, Meghan C. Campbell, Stephen M. Moerlein, Zhude Tu, Joel S. Perlmutter
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{"title":"PET Quantification of [18F]VAT in Human Brain and Its Test–Retest Reproducibility and Age Dependence","authors":"John L. O’Donnell, Anil Kumar Soda, Hao Jiang, Scott A. Norris, Baijayanta Maiti, Morvarid Karimi, Meghan C. Campbell, Stephen M. Moerlein, Zhude Tu, Joel S. Perlmutter","doi":"10.2967/jnumed.123.266860","DOIUrl":"https://doi.org/10.2967/jnumed.123.266860","url":null,"abstract":"<sec><st>Visual Abstract</st><p><fig loc=\"float\"><link locator=\"jnumed.123.266860absf1\"></fig></p></sec>","PeriodicalId":22820,"journal":{"name":"The Journal of Nuclear Medicine","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140547842","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
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